Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CASP14 Gene

protein-coding   GIFtS: 60
GCID: GC19P015160

Caspase 14, Apoptosis-Related Cysteine Peptidase

(Previous names: caspase 14, apoptosis-related cysteine protease)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Caspase 14, Apoptosis-Related Cysteine Peptidase1 2
Caspase 14, Apoptosis-Related Cysteine Protease1 2
Apoptosis-Related Cysteine Protease1 2
CASP-142 3
caspase-142
EC 3.4.22.-3

External Ids:    HGNC: 15021   Entrez Gene: 235812   Ensembl: ENSG000001051417   OMIM: 6058485   UniProtKB: P319443   

Export aliases for CASP14 gene to outside databases

Previous GC identifers: GC19P015542 GC19P015008 GC19P015024 GC19P014730


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CASP14 Gene:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of
caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes
which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small,
that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8
and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The
expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is
important for the formation of the skin barrier. (provided by RefSeq, Jul 2008)

GeneCards Summary for CASP14 Gene:
CASP14 (caspase 14, apoptosis-related cysteine peptidase) is a protein-coding gene. Diseases associated with CASP14 include plasma cell neoplasm, and middle ear cholesteatoma. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CASP16.

UniProtKB/Swiss-Prot: CASPE_HUMAN, P31944
Function: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a
role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by
proteolytically processing filaggrin (By similarity)

summary for CASP14 Gene:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.

Gene Wiki entry for CASP14 (Caspase 14) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CASP14 gene promoter:
         AhR   Elk-1   p53   AML1a   FOXO3   HNF-3beta   FOXO3b   C/EBPalpha   Arnt   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCASP14 promoter sequence
   Search Chromatin IP Primers for CASP14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CASP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

CASP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP14 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015160:  view genomic region     (about GC identifiers)

Start:
15,160,195 bp from pter      End:
15,169,104 bp from pter
Size:
8,910 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CASPE_HUMAN, P31944 (See protein sequence)
Recommended Name: Caspase-14 precursor  
Size: 242 amino acids; 27680 Da
Subunit: Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits
Secondary accessions: O95823 Q3SYC9

Explore the universe of human proteins at neXtProt for CASP14: NX_P31944

Explore proteomics data for CASP14 at MOPED


See CASP14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_036246.1  
ENSEMBL proteins: 
 ENSP00000393417   ENSP00000221740  

CASP14 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Enzo Life Sciences proteins for CASP14
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for CASP14
OriGene Custom MassSpec
OriGene Custom Protein Services for CASP14
GenScript Custom Purified and Recombinant Proteins Services for CASP14
Novus Biologicals CASP14 Protein
Sino Biological Recombinant Protein for CASP14
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CASP14

CASP14 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Cell Signaling Technology (CST) Antibodies for CASP14 
OriGene Antibodies for CASP14
OriGene Custom Antibody Services for CASP14
Novus Biologicals CASP14 Antibodies
Abcam antibodies for CASP14
Cloud-Clone Corp. Antibodies for CASP14
ThermoFisher Antibodies for CASP14
LSBio Antibodies in human, mouse, rat for CASP14

CASP14 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CASP14
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CASP14
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CASP14
Cloud-Clone Corp. CLIAs for CASP14


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
IUPHAR Guide to PHARMACOLOGY protein family classification: Caspase 14
Caspases

5 InterPro protein domains:
 IPR001309 Pept_C14_ICE_p20
 IPR002138 Pept_C14_p10
 IPR015917 Pept_C14A_p45_core
 IPR011600 Pept_C14_caspase
 IPR016129 Pept_C14_ICE_p20_AS

Graphical View of Domain Structure for InterPro Entry P31944

ProtoNet protein and cluster: P31944

1 Blocks protein domain: IPB002398 Interleukin-1B converting enzyme signature

UniProtKB/Swiss-Prot: CASPE_HUMAN, P31944
Similarity: Belongs to the peptidase C14A family


CASP14 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CASPE_HUMAN, P31944
Function: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a
role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by
proteolytically processing filaggrin (By similarity)
Induction: In undifferentiated keratinocytes under postconfluency growth conditions (in vitro)

     Genatlas biochemistry entry for CASP14:
caspase 14,cysteine containing aspartate-specific protease,stored in the mitochondrial intermembrane space and
released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,homolog to murine CASP14 expressed
in embryo and in adult skin

     Enzyme Number (IUBMB): EC 3.4.22.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004197cysteine-type endopeptidase activity IBA--
GO:0008234cysteine-type peptidase activity ----
     
CASP14 for ontologies           About GeneDecksing


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Casp14):
 homeostasis/metabolism  integument 

CASP14 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Casp14tm1Wdec for CASP14

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CASP14
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CASP14

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CASP14
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CASP14

miRNA
Products:
    
miRTarBase miRNAs that target CASP14:
hsa-mir-335-5p (MIRT016842)

Block miRNA regulation of human, mouse, rat CASP14 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate CASP14:
hsa-miR-549 hsa-miR-569 hsa-miR-185 hsa-miR-4306 hsa-miR-1253
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CASP14
Predesigned siRNA for gene silencing in human, mouse, rat CASP14

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CASP14

Clone
Products:
     
OriGene clones in human, mouse for CASP14 (see all 5)
OriGene ORF clones in mouse, rat for CASP14
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CASP14 (NM_012114)
Sino Biological Human cDNA Clone for CASP14
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP14
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP14

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CASP14
Browse ESI BIO Cell Lines and PureStem Progenitors for CASP14 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP14


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
CASPE_HUMAN, P31944: Cytoplasm. Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol3
cytoskeleton2
extracellular2
mitochondrion1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005737cytoplasm IBA--
GO:0045095keratin filament IEA--

CASP14 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for CASP14 About    
See pathways by source

SuperPathContained pathways About
1TNF Signaling
Death Receptor Signaling0.50
2p53 Signaling
p53 Pathway0.38
3EGFR Signaling Pathway
EGFR Signaling Pathway
4Apoptosis and Autophagy
Apoptosis and Autophagy

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Cell Signaling Technology (CST) Pathway for CASP14
    Apoptosis and Autophagy

3 Sino Biological Pathways for CASP14
    EGFR Signaling Pathway
p53 Pathway
Death Receptor Signaling



CASP14 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP14: 
          Apoptosis 384HT in human mouse rat
          Apoptosis in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for CASP14

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for CASP14 (P319443 ENSP000002217404) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
CASP10Q928513, ENSP000002861864I2D: score=2 STRING: ENSP00000286186
CASP4P496623, ENSP000003885664I2D: score=2 STRING: ENSP00000388566
CASP8Q147903, ENSP000003512734I2D: score=2 STRING: ENSP00000351273
CAPN1P073843, ENSP000002792474I2D: score=1 STRING: ENSP00000279247
USP53Q70EK83, ENSP000002740304I2D: score=2 STRING: ENSP00000274030
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis ----
GO:0006915apoptotic process ----
GO:0008544epidermis development TAS10203698
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage IBA--
GO:0031424keratinization TAS18309324

CASP14 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
Selected ApexBio Compounds for CASP14 (see all 12)     About this table
CompoundAction CAS #
Apoptosis InhibitorCell-permeable caspase-3 inhibitor[54135-60-3]
Caspase-3/7 Inhibitor ICell-permeable and irreversible inhibitor of caspase-3 and -7[220509-74-0]
CisplatinChemotherapy agent, induces apoptosis[15663-27-1]
PAC-1Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3[315183-21-2]
Q-VD-OphCell-permeable, irreversible pan-caspase inhibitor[1135695-98-5]
VX-765 Novel Caspase-1 inhibitor[273404-37-8]
Z-DEVD-FMKCell-permeable, and irreversible caspase-3 inhibitor[210344-95-9]
Z-DQMD-FMKCell-permeable caspase-3 inhibitor--
Z-FA-FMKEffector caspases 2, 3, 5, and 7--
Z-VAD-FMKCell-permeable, irreversible pan-caspase inhibitor[187389-52-2]

Compounds for CASP14 available from Tocris Bioscience    About this table
CompoundAction CAS #
AZ 10417808Selective non-peptide caspase-3 inhibitor[331645-84-2]
Z-DQMD-FMKCaspase-3 inhibitor--
CisplatinPotent pro-apoptotic anticancer agent; activates caspase-3[15663-27-1]
Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor --
Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

6 Novoseek inferred chemical compound relationships for CASP14 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine 56.7 9 9414118 (1), 8643593 (1), 18041091 (1), 16430140 (1) (see all 9)
tetrapeptide 52.4 2 16854378 (1), 10764048 (1)
egcg 49.5 9 15537824 (4), 17620095 (2), 17436577 (1)
aspartate 18.3 4 12200134 (2), 12181750 (1)
retinoic acid 7.64 3 15331408 (2)
calcium 0 1 12181750 (1)



CASP14 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for CASP14 gene: 
NM_012114.2  

Unigene Cluster for CASP14:

Caspase 14, apoptosis-related cysteine peptidase
Hs.466057  [show with all ESTs]
Unigene Representative Sequence: EU502748
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000427043(uc010dzv.2) ENST00000598738 ENST00000221740
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CASP14 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate CASP14:
hsa-miR-549 hsa-miR-569 hsa-miR-185 hsa-miR-4306 hsa-miR-1253
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CASP14
Predesigned siRNA for gene silencing in human, mouse, rat CASP14
Clone
Products:
     
OriGene clones in human, mouse for CASP14 (see all 5)
OriGene ORF clones in mouse, rat for CASP14
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CASP14 (NM_012114)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP14
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP14
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CASP14
OriGene qSTAR qPCR primer pairs in human, mouse for CASP14
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CASP14
  QuantiTect SYBR Green Assays in human, mouse, rat CASP14
  QuantiFast Probe-based Assays in human, mouse, rat CASP14

Additional mRNA sequence: 

AF097874.1 AK313992.1 BC069541.1 BC103868.1 BC103869.1 EU262664.1 EU502748.1 

5 DOTS entries:

DT.91716894  DT.91756482  DT.91716891  DT.121486669  DT.91730497 

16 AceView cDNA sequences:

BC069541 NM_012114 AF097874 BF380910 BF843203 BF739066 BE940739 BF914944 
BF093917 AW796525 BF737240 AW796661 BE939716 BQ300908 BF916315 BF380585 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

CASP14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATTCACTCT
CASP14 Expression
About this image


CASP14 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Epidermis (Integumentary System)    fully expand to see all 2 entries
         Corneocytes Stratified Epidermis
         skin 2 ; epidermal cells   
 
 Epithelial Cells
         Corneocytes Stratified Epidermis
 
 NULL (Integumentary System)
         skin 2 ; epidermal cells   
 
 Uterus (Reproductive System)
CASP14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CASP14 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.466057

UniProtKB/Swiss-Prot: CASPE_HUMAN, P31944
Tissue specificity: Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum
granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands
(at protein level). In psoriatic skin only expressed at very low levels

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP14: 
          Apoptosis 384HT in human mouse rat
          Apoptosis in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CASP14
OriGene qSTAR qPCR primer pairs in human, mouse for CASP14
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CASP14
QuantiTect SYBR Green Assays in human, mouse, rat CASP14
QuantiFast Probe-based Assays in human, mouse, rat CASP14
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP14

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for CASP14 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Casp141 , 5 caspase 141, 5 78.84(n)1
75.1(a)1
  10 (39.72 cM)5
123651  NM_009809.51  NP_033939.11 
 787119975 
chicken
(Gallus gallus)
Aves CASP176
Gallus gallus caspase 14, apoptosis-related cystei...
17(a)
many ↔ many
JH376331.1(64939-67734)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
33(a)
1 → many
GL343324.1(516560-527428)
zebrafish
(Danio rerio)
Actinopterygii caspa6
caspase a
18(a)
many ↔ many
16(44763011-44774004) ENSDARG00000008165
fruit fly
(Drosophila melanogaster)
Insecta Nc6
Dredd6
Death related ced-3/Nedd2-like protein
11(a)
10(a)
many ↔ many
many ↔ many
3L(9961579-9964102)
X(527553-529760)
worm
(Caenorhabditis elegans)
Secernentea csp-36
Protein CSP-3 (csp-3) mRNA, complete cds
17(a)
many ↔ many
I(11888503-11889340) WBGene00000821


ENSEMBL Gene Tree for CASP14 (if available)
TreeFam Gene Tree for CASP14 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for CASP14 gene
CASP162  CASP62  CASP82  CASP122  CASP92  CASP72  CASP32  CASP22  
CASP12  CASP52  CASP102  CASP42  
3 SIMAP similar genes for CASP14 using alignment to 3 protein entries:     CASPE_HUMAN (see all proteins):
DKFZp586A181    CASP16    CASP2

CASP14 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for CASP14 (see all 344)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1884178431,2
--15158417(+) GGATCC/TCTTGA 1 -- us2k10--------
rs1483829761,2
--15158437(+) TTCGAG/TACCAG 1 -- us2k10--------
rs104024091,2
C,F,A--15158454(+) caacaC/Tagcaa 1 -- us2k17Minor allele frequency- T:0.38NA WA EA 252
rs23667271,2
C,H--15158484(-) ttcctT/Caagat 1 -- us2k1 trp311Minor allele frequency- C:0.00NS NA WA CSA 232
rs104269941,2
C,F,A--15158497(+) aagtaG/Acaagg 1 -- us2k14Minor allele frequency- A:0.36WA NA EA 360
rs1172531821,2
C,F--15158532(+) CAGCTG/TCCCAG 1 -- us2k11Minor allele frequency- T:0.03NA 120
rs782078231,2
F--15158537(+) GCCCAG/AGAGGC 1 -- us2k11Minor allele frequency- A:0.33NA 6
rs1836241841,2
C--15158578(+) TTTTAA/GGCTGC 1 -- us2k10--------
rs1413908471,2
--15158615(+) TCCAGC/TCTGGG 1 -- us2k10--------
rs104013531,2
C,F,A,H--15158638(+) tctccG/Aaaaaa 1 -- us2k1 trp311Minor allele frequency- A:0.19NS EA NA WA 722

HapMap Linkage Disequilibrium report for CASP14 (15160195 - 15169104 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CASP14:    About this table    
Variant IDTypeSubtypePubMed ID
dgv1058e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CASP14
DNA2.0 Custom Variant and Variant Library Synthesis for CASP14

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 605848    OMIM disorders: --

Selected diseases for CASP14 (see all 28):    
About MalaCards
plasma cell neoplasm    middle ear cholesteatoma    glanders    childhood leukemia
eczema herpeticum    myocardial infarction    cholesteatoma    gastrointestinal stromal tumor
keloids    candidiasis    psoriasis    male infertility
lung adenocarcinoma    alzheimer's disease    ulcerative colitis    hodgkin's lymphoma
diabetic retinopathy    infertility    non-hodgkin lymphoma    choroiditis


CASP14 for disorders           About GeneDecksing

7 Novoseek inferred disease relationships for CASP14 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis 14 3 15619438 (1), 15556625 (1)
carcinoma squamous cell 7.65 4 15537824 (1), 16061209 (1), 17366476 (1)
breast cancer 0.0455 1 16061209 (1)
necrosis 0 1 16907856 (1)
inflammation 0 2 17558860 (1), 16061862 (1)
tumors 0 10 16061862 (2), 19846913 (2), 15537824 (1), 16061209 (1)
cancer 0 14 17558860 (2), 16061862 (2), 19846913 (1), 17436577 (1)

Genetic Association Database (GAD): CASP14
Human Genome Epidemiology (HuGE) Navigator: CASP14 (7 documents)

Export disorders for CASP14 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for CASP14 gene, integrated from 10 sources (see all 85):
(articles sorted by number of sources associating them with CASP14)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression and transcriptional regulation of caspase-14 in simple and complex epithelia. (PubMed id 12181750)1, 2, 9 Pistritto G.... Alnemri E.S. (Cell Death Differ. 2002)
  2. Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation. (PubMed id 12200134)1, 2, 9 Chien A.J.... Kuechle M.K. (Biochem. Biophys. Res. Commun. 2002)
  3. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing. (PubMed id 11175259)1, 2, 9 Lippens S.... Declercq W. (Cell Death Differ. 2000)
  4. Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation. (PubMed id 11062009)1, 2, 9 Eckhart L.... Tschachler E. (Biochem. Biophys. Res. Commun. 2000)
  5. Identification of a new caspase homologue: caspase-14. (PubMed id 10203698)1, 3, 9 Van de Craen M....Vandenabeele P. (Cell Death Differ. 1998)
  6. Mutational analysis of caspase-14 gene in common carcinomas. (PubMed id 17558860)1, 4, 9 Yoo N.J....Lee S.H. (Pathology 2007)
  7. Caspase-14 is a novel developmentally regulated protease. (PubMed id 9792675)1, 3, 9 Hu S....Dixit V.M. (J. Biol. Chem. 1998)
  8. Mutational analysis of caspase genes in prostate carcinomas. (PubMed id 20402676)1, 4 Kim M.S....Lee S.H. (APMIS 2010)
  9. Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors. (PubMed id 19269008)1, 4 Kim Y.R....Lee S.H. (Hum. Pathol. 2009)
  10. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 23581 HGNC: 1502 AceView: CASP14 Ensembl:ENSG00000105141 euGenes: HUgn23581
ECgene: CASP14 H-InvDB: CASP14

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for CASP14 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CASP14 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for CASP14 gene:
Search GeneIP for patents involving CASP14

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for CASP14   OriGene RNAi products in human, mouse, rat for CASP14  
 OriGene qPCR primer pairs and template standards for CASP14   OriGene Protein Over-expression Lysate for CASP14  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for CASP14  
 OriGene qSTAR qPCR primer pairs in human, mouse for CASP14   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for CASP14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CASP14   OriGene Custom Protein Services for CASP14  

 
 
 Block miRNA regulation of human, mouse, rat CASP14 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CASP14
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CASP14 Predesigned siRNA for gene silencing in human, mouse, rat CASP14
 QuantiFast Probe-based Assays in human, mouse, rat CASP14 QuantiTect SYBR Green Assays in human, mouse, rat CASP14
 PCR Arrays including human, mouse, rat CASP14 Search Chromatin IP Primers for CASP14
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CASP14  Search GeneGlobe Interaction Network for CASP14
 Regulatory tfbs in CASP14 promoter
 GenScript Custom Purified and Recombinant Proteins Services for CASP14 GenScript cDNA clones with any tag delivered in your preferred vector for CASP14
 GenScript Custom Assay Services for CASP14 GenScript Custom overexpressing Cell Line Services for CASP14
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Antibodies & Assays for CASP14 

 Tocris compounds for CASP14
 Proteins for CASP14
 Browse Sino Biological Cell Lysates
 cDNA Clones for CASP14
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Proteins for CASP14
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 CASP14 antibodies
 CASP14 proteins
 Antibodies for CASP14
 See all of Abcam's Antibodies, Kits and Proteins for CASP14
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for CASP14
 Antibodies for CASP14
 ELISAs for CASP14
 CLIAs for CASP14



 Browse ESI BIO Cell Lines and PureStem Progenitors for CASP14
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP14
 Browse SwitchGear 3'UTR luciferase reporter plasmids for CASP14
 SwitchGear Promoter luciferase reporter plasmids for CASP14
 ThermoFisher Antibodies for CASP14
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP14
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CASP14
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CASP14
 LSBio Antibodies in human, mouse, rat for CASP14
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 ApexBio compounds for CASP14
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      CASP14 gene at Home site.
Version: 3.12.162 20 Aug 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4