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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CASP12 Gene

protein-coding GIFtS: 50
GCID: GC11M104757

caspase 12 (gene/pseudogene)

(Previous names: caspase 12 pseudogene 1, caspase 12 )
(Previous symbol: CASP12P1)

Explore 6 diseases affiliated with
CASP12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 5

Aliases
Caspase 12 (Gene/Pseudogene)¹ ²		Caspase 12¹
CASP12P1¹ ² ⁵		Inactive Caspase-12²
Caspase 12 Pseudogene 1¹ ²		EC 3.4.22⁸
CASP-12² ³

External Ids:	HGNC: 19004¹	Entrez Gene: 100506742²	Ensembl: ENSG00000204403⁷	OMIM: 608633⁵	UniProtKB: Q6UXS9³

ORGUL members:	fRNAdb¹⁰:FR054980
	NCBI:AF464191
	NONCODE:n409665 n409667 n409666 n409670 n409663	see all 8
	RNAdb:LIT2097

Export aliases for CASP12 gene to outside databases

Previous GC identifer: GC11M104261

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CASP12:

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene

is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents,

the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene

contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have

the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in

individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to

severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. (provided by RefSeq,

Feb 2011)

UniProtKB/Swiss-Prot: CASPC_HUMAN, Q6UXS9

Function: Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during

infections. Reduces activation of NF-kappa-B in response to TNF

summary for CASP12:

Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of

apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and

effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,

upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector

caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the

executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase

Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors

such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For

example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form

part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by

inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of

many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory

disease.

fRNAdb sequence ontology for CASP12:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CASP12 gene promoter:
Pbx1a p53 ATF-2 AP-4 Tal-1beta HNF-3beta Evi-1 FOXO4 ITF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CASP12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3

CASP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP12 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M104757: view genomic region (about GC identifiers)

Start:	104,756,445 bp from pter	End:	104,769,397 bp from pter
Size:	12,953 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CASP12

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CASPC_HUMAN, Q6UXS9 (See protein sequence)

Recommended Name: Inactive caspase-12

Size: 341 amino acids; 38865 Da

Secondary accessions: D6RBN7

Alternative splicing: 3 isoforms: Q6UXS9-1 Q6UXS9-2 Q6UXS9-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CASP12: NX_Q6UXS9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UXS9

4/6 DME Specific Peptides for CASP12 (Q6UXS9) (see all 6)

SDSTFLV

LHDDTIF

DKPKVII

HVEKDFIAF

CASP12 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001177945.1

ENSEMBL proteins:

ENSP00000427128 ENSP00000421408 ENSP00000424038 ENSP00000426427 ENSP00000425652

ENSP00000423970 ENSP00000427437 ENSP00000423899 ENSP00000424963 ENSP00000421815

ENSP00000426566

Human Recombinant Protein Products for CASP12:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CASP12

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	--	--
GO:0005792	microsome	--	--
GO:0005829	cytosol	--	--

CASP12 for ontologies About GeneDecksing

CASP12 Antibody Products:

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	ThermoFisher Antibodies for CASP12

Assay Products for CASP12:

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	Uscn ELISAs and CLIAs for CASP12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CASP12 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR001309 Pept_C14_ICE_p20

IPR011029 DEATH-like_dom

IPR017350 Caspase_IL-1_beta

IPR002138 Pept_C14_p10

IPR015917 Pept_C14_p45_core

Graphical View of Domain Structure for InterPro Entry Q6UXS9

ProtoNet protein and cluster: Q6UXS9

2 Blocks protein families:

IPB001315 CARD interaction domain

IPB002398 Interleukin-1B converting enzyme signature

UniProtKB/Swiss-Prot: CASPC_HUMAN, Q6UXS9

Similarity: Belongs to the peptidase C14A family

Similarity: Contains 1 CARD domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CASPC_HUMAN, Q6UXS9

Function: Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during

infections. Reduces activation of NF-kappa-B in response to TNF

Enzyme Number (IUBMB): EC 3.4.22²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	--	--
GO:0004175	endopeptidase activity	--	--
GO:0004197	cysteine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0008234	cysteine-type peptidase activity	--	--

CASP12 for ontologies About GeneDecksing

Phenotypes:
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Casp12):

behavior/neurological	cellular	homeostasis/metabolism	immune system	mortality/aging
nervous system	normal	tumorigenesis

CASP12 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CASP12: Casp12^tm1Dwni Casp12^tm1Yuan

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CASP12

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP12

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Apoptosis Pathway

Apoptosis Pathway

1.00

Apoptotic Pathways in Synovial Fibroblasts

Mitochondrial Apoptosis

0.73

Sorafenib Pharmacodynamics

VEGF Pathway

0.36

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Alzheimers Disease

0.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CASP12

Mitochondrial Apoptosis

2 Tocris Bioscience Pathways for CASP12

	Apoptosis Pathway
	VEGF Pathway

3 BioSystems Pathways for CASP12

	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Alzheimers Disease

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CASP12

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0006915	apoptotic process	--	--
GO:0006926	virus-infected cell apoptotic process	IEA	--
GO:0007568	aging	--	--
GO:0009409	response to cold	--	--

CASP12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CASP12 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ac-LEHD-AFC	Fluorogenic caspase substrate	[210345-03-2]
Z-VAD-FMK	Cell-permeable, irreversible caspase inhibitor	--

Search CenterWatch for drugs/clinical trials and news about CASP12 / CASPC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CASP12 gene:

NM_001191016.1

Unigene Cluster for CASP12:

Caspase 12 (gene/pseudogene)

Hs.476989 [show with all ESTs]

Unigene Representative Sequence: NM_001191016

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000422698(uc001pht.2) ENST00000458137(uc001phw.2) ENST00000375726

ENST00000447913(uc001phx.2) ENST00000446862(uc021qpk.1) ENST00000441710(uc009yxf.2)

ENST00000433738(uc021qpm.1) ENST00000448103(uc001phv.2) ENST00000417998(uc001phu.2)

ENST00000494737(uc021qpl.1) ENST00000508062

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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASP12

Additional cDNA sequence:

AF464191.1 AF464192.1 AF464193.1 AF464194.1 AF464195.1 AF486844.1 AF486845.1 AF486846.1

AF486847.1 AY358222.1 NR_034061.1 NR_034063.1 NR_034064.1 NR_034065.1 NR_034066.1 NR_034067.1

NR_034068.1 NR_034070.1 NR_034071.1

4 DOTS entries:

DT.100020552 DT.97835158 DT.120726955 DT.40240203

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CASP12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
Genevestigator expression for CASP12

SOURCE GeneReport for Unigene cluster: Hs.476989

UniProtKB/Swiss-Prot: CASPC_HUMAN, Q6UXS9

Tissue specificity: Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and

testis

SABiosciences Custom PCR Arrays for CASP12

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CASP12 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1P0X7_CHICK⁶	caspase 1	32(a)	1 → many	19(644765-649090)
lizard (Anolis carolinensis)	Reptilia	--	--	39(a)	1 → many	GL344618.1(3490-9499)
zebrafish (Danio rerio)	Actinopterygii	caspa⁶ caspbl⁶ (see all 5)	caspase b, like (see all 5)	25(a) 24(a) (see all 5)	many ↔ many many ↔ many (see all 5)	16(44763011-44774004) 1(58792132-58801668)
fruit fly (Drosophila melanogaster)	Insecta	Dredd⁶ Nc⁶	Nedd2-like caspase	9(a) 10(a)	1 ↔ many possible ortholog	X(527553-529760) 3L(9961579-9964102)
worm (Caenorhabditis elegans)	Secernentea	csp-2⁶ ced-3⁶ (see all 4)	CaSPase family member (csp-2) Cell death protein 3 Cell death protein 3 subunit ... (see all 4)	7(a) 15(a) (see all 4)	possible ortholog possible ortholog (see all 4)	IV(6307728-6315708) IV(13199206-13206272)

ENSEMBL Gene Tree for CASP12 (if available)
TreeFam Gene Tree for CASP12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CASP12 gene

CASP16² CASP6² CASP8² CASP9² CASP7² CASP3² CASP2² CASP14²

CASP1² CASP5² CASP10² CASP4²

6 SIMAP similar genes for CASP12 using alignment to 7 protein entries: CASPC_HUMAN (see all proteins):

DKFZp586A181 CASP5 LOC643733 mih1/Tx CASP1 CASP4

CASP12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CASPC_HUMAN, Q6UXS9

Polymorphism: The most frequent variant has a stop codon instead of Arg-125, giving rise to truncated forms of isoform

1 (named delta, epsilon, eta, gamma) and isoform 3 (iota, teta). The variant Arg-125 (Csp12-L) is rare, except in some

populations from sub-Saharan Africa. Csp12-L may increase the susceptibility to severe sepsis, and may also increase

the mortality rate in sepsis patients

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs497116^1,2	C,F,A,H	other	104763117(-)	`GGATGT/CGAGAT`	2	/R /*	stg¹		22		NS EA NA WA CSA EU	2289
rs79462493^1,2		--	100687052(+)	`TGTCTC/TTGGGG`	1	--	ds500¹		2		CSA WA	120
rs73629640^1,2	C,F	--	100687182(+)	`AAACAC/GAATCT`	1	--	ds500¹		1		WA	118
rs76878841^1,2		--	100688305(+)	`CTTGAG/AGGAAA`	10	--	int¹ ds500¹		2		CSA WA	120
rs75322920^1,2	C,F	--	100688406(+)	`GTTTCG/ACTGGG`	10	--	int¹ ds500¹		3		WA CSA	122
rs113476081^1,2	C	--	100688450(+)	`TATAAC/ATAGTG`	10	--	ds500¹ int¹		1		WA	2
rs73629643^1,2	C	--	100688737(+)	`AAAAGC/TCATGG`	10	--	int¹		1		WA	2
rs3888096^1,2	F,H	--	100688757(+)	`AGGTTG/ATAGCT`	10	--	int¹		6		NS EA CSA WA	536
rs181763844^1,2	C	--	100689061(+)	`TTTTGA/GAAAAT`	11	F	int¹ nc-transcript-variantsyn¹		0	--	--	--	--
rs56670368^1,2	C,F	--	100689250(+)	`AAAAAA/CATCTG`	10	--	int¹		3		WA CSA	122

HapMap Linkage Disequilibrium report for CASP12 (104756445 - 104769397 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CASP12
5 CNVs: 31846 2955 86006 8695 66054
Human Gene Mutation Database (HGMD): CASP12

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CASP12 for disorders           About GeneDecksing

OMIM gene information: 608633OMIM information:
6 diseases for CASP12:    About MalaCards

sepsis candidiasis anoxia nephropathy

retinitis malaria

Human Genome Epidemiology (HuGE) Navigator: CASP12 (4 documents)

Export disorders for CASP12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CASP12 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with CASP12)

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Population distribution of the functional caspase-12 allele. (PubMed id 16917906)^{1, 2, 3} Kachapati K.... Dean M. (2006)
Spread of an inactive form of caspase-12 in humans is due to recent positive selection. (PubMed id 16532395)^{1, 2, 3} Xue Y....Tyler-Smith C. (2006)
Human caspase 12 has acquired deleterious mutations. (PubMed id 12054529)^{1, 2, 3} Fischer H.... Tschachler E. (2002)
Differential modulation of endotoxin responsiveness by human caspase- 12 polymorphisms. (PubMed id 15129283)^{1, 2} Saleh M....Nicholson D.W. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Characterization of seven murine caspase family members. (PubMed id 9038361)^{1, 3} Van de Craen M....Fiers W. (1997)
The impact of caspase-12 on susceptibility to candidem ia. (PubMed id 21706251)¹ Rosentul D.C....Netea M.G. (2012)
A possible mechanism for maintenance of the deleterio us allele of human CASPASE-12. (PubMed id 21872999)¹ Hermel E. and Klapstein K.D. (2011)
Purification of catalytically active caspase-12 and i ts biochemical characterization. (PubMed id 20646990)¹ Lee H.J....Park I.S. (2010)
Genetic variation of innate immune genes in HIV-infec ted african patients with or without oropharyngeal candidiasis. (PubMed id 20577092)¹ Plantinga T.S....Netea M.G. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100506742	HGNC: 19004	Ensembl:ENSG00000204403	euGenes: HUgn100506742	ECgene: CASP12
H-InvDB: CASP12

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CASP12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CASP12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CASP12 gene:
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GeneCards and IP:
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