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Aliases for CASP12 Gene

Aliases for CASP12 Gene

  • Caspase 12 (Gene/Pseudogene) 2 3
  • Caspase 12 Pseudogene 1 2 3
  • CASP12P1 3 6
  • CASP-12 3 4
  • Inactive Caspase-12 3
  • Caspase 12 2
  • EC 3.4.22 63

External Ids for CASP12 Gene

Previous HGNC Symbols for CASP12 Gene

  • CASP12P1

Previous GeneCards Identifiers for CASP12 Gene

  • GC11M104261
  • GC11M104757

Summaries for CASP12 Gene

Entrez Gene Summary for CASP12 Gene

  • Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for CASP12 Gene

CASP12 (Caspase 12 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with CASP12 include prion disease and myocardial infarction. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptosis Pathway. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP12 Gene

  • Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.

Tocris Summary for CASP12 Gene

  • Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory disease.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP12 Gene

Genomics for CASP12 Gene

Regulatory Elements for CASP12 Gene

Genomic Location for CASP12 Gene

104,885,718 bp from pter
104,898,670 bp from pter
12,953 bases
Minus strand

Genomic View for CASP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP12 Gene

Proteins for CASP12 Gene

  • Protein details for CASP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive caspase-12
    Protein Accession:
    Secondary Accessions:
    • D6RBN7

    Protein attributes for CASP12 Gene

    341 amino acids
    Molecular mass:
    38865 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASP12 Gene


neXtProt entry for CASP12 Gene

Proteomics data for CASP12 Gene at MOPED

Selected DME Specific Peptides for CASP12 Gene

Post-translational modifications for CASP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for CASP12 Gene

Suggested Antigen Peptide Sequences for CASP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CARD domain.
  • Belongs to the peptidase C14A family.
  • Contains 1 CARD domain.
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP12: view

Function for CASP12 Gene

Molecular function for CASP12 Gene

UniProtKB/Swiss-Prot Function:
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.

Enzyme Numbers (IUBMB) for CASP12 Gene

Gene Ontology (GO) - Molecular Function for CASP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity --
GO:0005515 protein binding --
GO:0008234 cysteine-type peptidase activity --
GO:0097200 NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA --
genes like me logo Genes that share ontologies with CASP12: view
genes like me logo Genes that share phenotypes with CASP12: view

Animal Models for CASP12 Gene

MGI Knock Outs for CASP12:

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for CASP12 Gene

Localization for CASP12 Gene

Gene Ontology (GO) - Cellular Components for CASP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IDA 10638761
GO:0072557 NOT IPAF inflammasome complex IBA --
GO:0072559 NOT NLRP3 inflammasome complex IBA --
GO:0097169 NOT AIM2 inflammasome complex IBA --
genes like me logo Genes that share ontologies with CASP12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CASP12 Gene

Pathways for CASP12 Gene

genes like me logo Genes that share pathways with CASP12: view

Pathways by source for CASP12 Gene

Interacting Proteins for CASP12 Gene

Gene Ontology (GO) - Biological Process for CASP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006915 apoptotic process --
GO:0030968 endoplasmic reticulum unfolded protein response IEA --
GO:0042981 regulation of apoptotic process IEA --
GO:0050727 NOT regulation of inflammatory response IBA --
genes like me logo Genes that share ontologies with CASP12: view

Drugs for CASP12 Gene

(5) Tocris Compounds for CASP12 Gene

Compound Action Cas Number
Ac-LEHD-AFC Fluorogenic caspase substrate [210345-03-2]
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 [15663-27-1]
Z-DQMD-FMK Caspase-3 inhibitor
Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]
Z-VDVAD-FMK Irreversible caspase-2 inhibitor
genes like me logo Genes that share compounds with CASP12: view

Transcripts for CASP12 Gene

mRNA/cDNA for CASP12 Gene

(1) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CASP12 Gene

Caspase 12 (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP12 Gene

No ASD Table

Relevant External Links for CASP12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CASP12 Gene

mRNA expression in normal human tissues for CASP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP12 Gene

This gene is overexpressed in Ovary (4.4).

Protein differential expression in normal tissues for CASP12 Gene

This gene is overexpressed in Lung (29.1), Breast (24.4), and Bone (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CASP12 Gene

SOURCE GeneReport for Unigene cluster for CASP12 Gene Hs.476989

mRNA Expression by UniProt/SwissProt for CASP12 Gene

Tissue specificity: Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.
genes like me logo Genes that share expressions with CASP12: view

Expression partners for CASP12 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CASP12 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP12 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Casp12 16
Casp12 36
  • 48 (a)
(Canis familiaris)
Mammalia CASP12 36
  • 40 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
-- 36
  • 39 (a)
-- 36
  • 35 (a)
-- 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
(Pan troglodytes)
Mammalia CASP12 36
  • 97 (a)
(Gallus gallus)
Aves -- 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
(Danio rerio)
Actinopterygii si:ch211-233g6.8 36
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dredd 36
  • 10 (a)
Nc 36
  • 13 (a)
Species with no ortholog for CASP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP12 Gene

Gene Tree for CASP12 (if available)
Gene Tree for CASP12 (if available)

Paralogs for CASP12 Gene

Paralogs for CASP12 Gene

(6) SIMAP similar genes for CASP12 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CASP12: view

Variants for CASP12 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CASP12 Gene

The most frequent variant has a stop codon instead of Arg-125, giving rise to truncated forms of isoform 1 (named delta, epsilon, eta, gamma) and isoform 3 (iota, teta). The variant Arg-125 (Csp12-L) is rare, except in some populations from sub-Saharan Africa. Csp12-L may increase the susceptibility to severe sepsis, and may also increase the mortality rate in sepsis patients

Sequence variations from dbSNP and Humsavar for CASP12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs476274 -- 104,895,273(+) aaaaa(G/T)gaaag intron-variant
rs479453 -- 104,893,240(-) CATGC(C/T)GTGAG intron-variant
rs483013 -- 104,897,758(-) GCTTC(C/T)CTGAA intron-variant
rs484438 -- 104,887,308(+) TATCT(A/G)CAAAT intron-variant
rs489229 -- 104,888,561(+) ctcat(A/G)tatcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP12 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv826072 CNV Loss 20364138
nsv832255 CNV Loss 17160897
dgv433e1 CNV Complex 17122850
nsv8869 CNV Gain+Loss 18304495
esv2656719 CNV Deletion 23128226
nsv898355 CNV Gain 21882294
esv27913 CNV Loss 19812545

Relevant External Links for CASP12 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for CASP12 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CASP12 Gene in MalaCards »

(2) Diseases for CASP12 Gene

Relevant External Links for CASP12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CASP12: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CASP12 Gene

Publications for CASP12 Gene

  1. Population distribution of the functional caspase-12 allele. (PMID: 16917906) Kachapati K. … Dean M. (Hum. Mutat. 2006) 2 3 4 48
  2. Spread of an inactive form of caspase-12 in humans is due to recent positive selection. (PMID: 16532395) Xue Y. … Tyler-Smith C. (Am. J. Hum. Genet. 2006) 2 3 4
  3. Human caspase 12 has acquired deleterious mutations. (PMID: 12054529) Fischer H. … Tschachler E. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  4. Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations. (PMID: 20423816) McCall M.B. … Netea M.G. (Eur. Cytokine Netw. 2010) 3 48
  5. Differential modulation of endotoxin responsiveness by human caspase- 12 polymorphisms. (PMID: 15129283) Saleh M. … Nicholson D.W. (Nature 2004) 3 4

Products for CASP12 Gene

Sources for CASP12 Gene

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