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Aliases for CASP10 Gene

Aliases for CASP10 Gene

  • Caspase 10 2 3 5
  • FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2 3 4
  • Caspase 10, Apoptosis-Related Cysteine Protease 2 3
  • ICE-Like Apoptotic Protease 4 3 4
  • CASP-10 3 4
  • FLICE2 3 4
  • MCH4 3 4
  • Caspase 10, Apoptosis-Related Cysteine Peptidase 2
  • Caspase 10 Apoptosis-Related Cysteine Peptidase 3
  • Interleukin-1B-Converting Enzyme 2 3
  • Apoptotic Protease MCH-4 3
  • Apoptotic Protease Mch-4 4
  • FADD-Like ICE2 3
  • EC 3.4.22.63 4
  • Caspase-10 3
  • ALPS2 3

External Ids for CASP10 Gene

Previous GeneCards Identifiers for CASP10 Gene

  • GC02P200264
  • GC02P200772
  • GC02P202011
  • GC02P202250
  • GC02P202223
  • GC02P201873
  • GC02P201756
  • GC02P202047
  • GC02P193898

Summaries for CASP10 Gene

Entrez Gene Summary for CASP10 Gene

  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

GeneCards Summary for CASP10 Gene

CASP10 (Caspase 10) is a Protein Coding gene. Diseases associated with CASP10 include Autoimmune Lymphoproliferative Syndrome, Type Ii and Lymphoma, Non-Hodgkin. Among its related pathways are TRAF Pathway and Apoptosis and survival Caspase cascade. GO annotations related to this gene include ubiquitin protein ligase binding and cysteine-type peptidase activity. An important paralog of this gene is CASP8.

UniProtKB/Swiss-Prot for CASP10 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC.

  • Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis.

  • Isoform C is proteolytically inactive.

Tocris Summary for CASP10 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Gene Wiki entry for CASP10 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP10 Gene

Genomics for CASP10 Gene

Regulatory Elements for CASP10 Gene

Enhancers for CASP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G201208 1.3 Ensembl ENCODE dbSUPER 40 +26.2 26246 1.8 BMI1 ZNF384 ARID3A ZNF366 ZSCAN5C ETV6 RELB IKZF2 CREM CHD2 CASP10 CASP8 STRADB ORC2 LOC105373835 PPIL3 MTND5P25 GC02M201164
GH02G201154 1.5 Ensembl ENCODE dbSUPER 32 -25.7 -25697 5.0 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 PPIL3 CASP10 LOC105373835 ORC2 CFLAR-AS1 GC02P201142
GH02G201182 1.3 ENCODE dbSUPER 31.2 +1.6 1637 4.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 DEK SP5 CASP10 CASP8 LOC105373835 ORC2 BICD1P1 PPIL3 CFLAR GC02M201164 MTND5P25
GH02G201114 1.9 FANTOM5 ENCODE dbSUPER 21.2 -58.7 -58666 19.0 CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 PPIL3 CFLAR CASP10 LOC100130026 CLK1 CFLAR-AS1 FAM126B LOC105373835 ORC2 CASP8
GH02G201211 1 Ensembl ENCODE dbSUPER 38.1 +29.1 29112 1.9 PKNOX1 BHLHE40 IKZF1 ETV6 IKZF2 CASP10 CASP8 CFLAR-AS1 STRADB ORC2 LOC105373835 PPIL3 CFLAR MTND5P25 GC02M201164
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CASP10 on UCSC Golden Path with GeneCards custom track

Promoters for CASP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128771 919 2401 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 DEK SP5

Genomic Location for CASP10 Gene

Chromosome:
2
Start:
201,182,881 bp from pter
End:
201,229,406 bp from pter
Size:
46,526 bases
Orientation:
Plus strand

Genomic View for CASP10 Gene

Genes around CASP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP10 Gene

Proteins for CASP10 Gene

  • Protein details for CASP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92851-CASPA_HUMAN
    Recommended name:
    Caspase-10
    Protein Accession:
    Q92851
    Secondary Accessions:
    • Q68HC0
    • Q6KF62
    • Q6KF63
    • Q8IUP5
    • Q8WYQ8
    • Q99845
    • Q9Y2U6
    • Q9Y2U7

    Protein attributes for CASP10 Gene

    Size:
    521 amino acids
    Molecular mass:
    58951 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit (By similarity). Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Interacts with RFFL and RNF34; negatively regulate CASP10 through proteasomal degradation. Interacts with RIOK3.

    Alternative splice isoforms for CASP10 Gene

neXtProt entry for CASP10 Gene

Post-translational modifications for CASP10 Gene

  • Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
  • Ubiquitination at posLast=192192 and posLast=271271
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for CASP10

Protein Products

No data available for DME Specific Peptides for CASP10 Gene

Domains & Families for CASP10 Gene

Suggested Antigen Peptide Sequences for CASP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q92851

UniProtKB/Swiss-Prot:

CASPA_HUMAN :
  • Belongs to the peptidase C14A family.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP10: view

Function for CASP10 Gene

Molecular function for CASP10 Gene

GENATLAS Biochemistry:
caspase 10,cysteine containing aspartate-specific protease,expressed in fetal lung,kidney,skeletal muscle,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis,homolog to C elegans cell death gene Ced-3
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp- -Gly.
UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC.
UniProtKB/Swiss-Prot Function:
Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis.
UniProtKB/Swiss-Prot Function:
Isoform C is proteolytically inactive.

Enzyme Numbers (IUBMB) for CASP10 Gene

Gene Ontology (GO) - Molecular Function for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 8755496
GO:0005515 protein binding IPI 12884866
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CASP10: view
genes like me logo Genes that share phenotypes with CASP10: view

Human Phenotype Ontology for CASP10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CASP10 Gene

Localization for CASP10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASP10 gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031265 CD95 death-inducing signaling complex IDA 11717445
GO:0097342 ripoptosome IDA 21737330
genes like me logo Genes that share ontologies with CASP10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CASP10 Gene

Pathways & Interactions for CASP10 Gene

genes like me logo Genes that share pathways with CASP10: view

SIGNOR curated interactions for CASP10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006915 apoptotic process TAS 10412980
GO:0007166 cell surface receptor signaling pathway TAS --
GO:0042981 regulation of apoptotic process TAS --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12884866
genes like me logo Genes that share ontologies with CASP10: view

Drugs & Compounds for CASP10 Gene

(6) Drugs for CASP10 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0
PD 150606 Pharma Non-peptide calpain inhibitor, Cell permeable calpain inhibitor 0

(1) Additional Compounds for CASP10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 101
110044-82-1

(3) Tocris Compounds for CASP10 Gene

Compound Action Cas Number
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 101 Calpain inhibitor; activates p53-dependent apoptosis 110044-82-1
PD 150606 Cell permeable calpain inhibitor 179528-45-1
genes like me logo Genes that share compounds with CASP10: view

Transcripts for CASP10 Gene

Unigene Clusters for CASP10 Gene

Caspase 10, apoptosis-related cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10:
SP11: -

ExUns: 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CASP10 Gene

GeneLoc Exon Structure for
CASP10
ECgene alternative splicing isoforms for
CASP10

Expression for CASP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CASP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP10 Gene

This gene is overexpressed in Whole Blood (x6.3) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for CASP10 Gene

This gene is overexpressed in Plasma (40.8) and Cervix (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CASP10 Gene



Protein tissue co-expression partners for CASP10 Gene

NURSA nuclear receptor signaling pathways regulating expression of CASP10 Gene:

CASP10

SOURCE GeneReport for Unigene cluster for CASP10 Gene:

Hs.5353

mRNA Expression by UniProt/SwissProt for CASP10 Gene:

Q92851-CASPA_HUMAN
Tissue specificity: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Evidence on tissue expression from TISSUES for CASP10 Gene

  • Blood(4.4)
  • Spleen(4.3)
  • Nervous system(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CASP10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • head
Thorax:
  • lung
Abdomen:
  • kidney
  • liver
  • spleen
  • stomach
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • lymph node
  • red blood cell
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with CASP10: view

Primer Products

Orthologs for CASP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP10 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia CASP10 34 35
  • 81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CASP10 35
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CASP10 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CASP10 34 35
  • 55.22 (n)
lizard
(Anolis carolinensis)
Reptilia CASP10 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casp10 34
  • 53.88 (n)
zebrafish
(Danio rerio)
Actinopterygii casp8l2 34 35
  • 47.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dcp-1 35
  • 29 (a)
ManyToMany
decay 35
  • 28 (a)
ManyToMany
Ice 35
  • 28 (a)
ManyToMany
Species where no ortholog for CASP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP10 Gene

ENSEMBL:
Gene Tree for CASP10 (if available)
TreeFam:
Gene Tree for CASP10 (if available)

Paralogs for CASP10 Gene

Paralogs for CASP10 Gene

(1) SIMAP similar genes for CASP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CASP10: view

Variants for CASP10 Gene

Sequence variations from dbSNP and Humsavar for CASP10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121909776 Pathogenic, Gastric cancer (GASC) [MIM:613659] 201,187,798(+) TGAAA(C/T)GGTGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs17860403 Pathogenic, Autoimmune lymphoproliferative syndrome 2A (ALPS2A) [MIM:603909] 201,208,114(+) GAGGC(C/T)TCTGT intron-variant, nc-transcript-variant, reference, missense
rs28936699 Pathogenic, Familial non-Hodgkin lymphoma (NHL) [MIM:605027] 201,209,388(+) CGAAG(C/T)AGATG downstream-variant-500B, reference, missense, utr-variant-3-prime
rs121909775 Pathogenic 201,205,929(+) GGATG(A/C/T)AAGGA intron-variant, nc-transcript-variant, reference, missense, stop-gained
rs398122800 Pathogenic 201,209,189(+) CGACG(-/A)GGGAC downstream-variant-500B, reference, utr-variant-3-prime, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP10 Gene

Variant ID Type Subtype PubMed ID
esv3593974 CNV loss 21293372
nsv1160898 CNV deletion 26073780
nsv584160 CNV loss 21841781
nsv821874 CNV loss 20364138
nsv961547 CNV duplication 23825009

Variation tolerance for CASP10 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASP10 Gene

Human Gene Mutation Database (HGMD)
CASP10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP10 Gene

Disorders for CASP10 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CASP10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autoimmune lymphoproliferative syndrome, type ii
  • autoimmune lymphoproliferative syndrome type 2a
lymphoma, non-hodgkin
  • lymphoma, non-hodgkin, somatic
gastric cancer, somatic
  • gastric cancer
gastric cancer
  • stomach cancer
autoimmune lymphoproliferative syndrome
  • autoimmune lymphoproliferative syndrome, type ib
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CASPA_HUMAN
  • Autoimmune lymphoproliferative syndrome 2A (ALPS2A) [MIM:603909]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269 PubMed:10412980}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Familial non-Hodgkin lymphoma (NHL) [MIM:605027]: Cancer that starts in cells of the lymph system, which is part of the bodys immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. {ECO:0000269 PubMed:12010812}. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:11973654}. Note=The gene represented in this entry is involved in disease pathogenesis.

Relevant External Links for CASP10

Genetic Association Database (GAD)
CASP10
Human Genome Epidemiology (HuGE) Navigator
CASP10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASP10
genes like me logo Genes that share disorders with CASP10: view

No data available for Genatlas for CASP10 Gene

Publications for CASP10 Gene

  1. Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas. (PMID: 19900088) Kim M.S. … Lee S.H. (Pathology 2009) 3 4 22 46 64
  2. Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma. (PMID: 18563783) Li C. … Wei Q. (Hum. Mutat. 2008) 3 4 22 46 64
  3. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (PMID: 8755496) Fernandes-Alnemri T. … Alnemri E.S. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 22 64
  4. Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas. (PMID: 20025484) Oh J.E. … Yoo N.J. (Pathology 2010) 3 4 22 64
  5. Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma. (PMID: 17071630) Lan Q. … Rothman N. (Carcinogenesis 2007) 3 22 46 64

Products for CASP10 Gene

Sources for CASP10 Gene

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