Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CASP10 Gene

Aliases for CASP10 Gene

  • Caspase 10, Apoptosis-Related Cysteine Peptidase 2 3
  • MCH4 3 4 6
  • FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2 3 4
  • Caspase 10, Apoptosis-Related Cysteine Protease 2 3
  • ICE-Like Apoptotic Protease 4 3 4
  • CASP-10 3 4
  • FLICE2 3 4
  • ALPS2 3 6
  • Interleukin-1B-Converting Enzyme 2 3
  • Apoptotic Protease MCH-4 3
  • Apoptotic Protease Mch-4 4
  • FADD-Like ICE2 3
  • EC 3.4.22.63 4
  • Caspase-10 3

External Ids for CASP10 Gene

Summaries for CASP10 Gene

Entrez Gene Summary for CASP10 Gene

  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

GeneCards Summary for CASP10 Gene

CASP10 (Caspase 10, Apoptosis-Related Cysteine Peptidase) is a Protein Coding gene. Diseases associated with CASP10 include autoimmune lymphoproliferative syndrome, type ii and casp10-related autoimmune lymphoproliferative syndrome. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP10 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC.

  • Isoform C is proteolytically inactive.

Tocris Summary for CASP10 Gene

  • Caspases (short for cysteinyl aspartate proteases) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of many disorders including stroke, Alzheimers disease, myocardial infarction, cancer, and inflammatory disease.

Gene Wiki entry for CASP10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP10 Gene

Genomics for CASP10 Gene

Genomic Location for CASP10 Gene

Start:
201,182,881 bp from pter
End:
201,229,406 bp from pter
Size:
46,526 bases
Orientation:
Plus strand

Genomic View for CASP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP10 Gene

Regulatory Elements for CASP10 Gene

Proteins for CASP10 Gene

  • Protein details for CASP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92851-CASPA_HUMAN
    Recommended name:
    Caspase-10
    Protein Accession:
    Q92851
    Secondary Accessions:
    • Q68HC0
    • Q6KF62
    • Q6KF63
    • Q8IUP5
    • Q8WYQ8
    • Q99845
    • Q9Y2U6
    • Q9Y2U7

    Protein attributes for CASP10 Gene

    Size:
    521 amino acids
    Molecular mass:
    58951 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit (By similarity). Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Interacts with RFFL and RNF34; negatively regulate CASP10 through proteasomal degradation.

    Alternative splice isoforms for CASP10 Gene

neXtProt entry for CASP10 Gene

Proteomics data for CASP10 Gene at MOPED

Post-translational modifications for CASP10 Gene

  • Cleavage by granzyme B and autocatalytic activity generate the two active subunits
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys192 and Lys271

No data available for DME Specific Peptides for CASP10 Gene

Domains for CASP10 Gene

Gene Families for CASP10 Gene

HGNC:
IUPHAR :

UniProtKB/Swiss-Prot:

CASPA_HUMAN
Domain:
  • Contains 2 DED (death effector) domains.:
    • Q92851
Family:
  • Belongs to the peptidase C14A family.:
    • Q92851
genes like me logo Genes that share domains with CASP10: view

Function for CASP10 Gene

Molecular function for CASP10 Gene

GENATLAS Biochemistry: caspase 10,cysteine containing aspartate-specific protease,expressed in fetal lung,kidney,skeletal muscle,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis,homolog to C elegans cell death gene Ced-3
UniProtKB/Swiss-Prot CatalyticActivity: Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp- -Gly
UniProtKB/Swiss-Prot Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC.
UniProtKB/Swiss-Prot Function: Isoform C is proteolytically inactive.

Enzyme Numbers (IUBMB) for CASP10 Gene

Gene Ontology (GO) - Molecular Function for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 10412980
GO:0005515 protein binding IPI 12884866
GO:0008234 cysteine-type peptidase activity --
GO:0031625 ubiquitin protein ligase binding IPI 15069192
GO:0035877 death effector domain binding IPI 11717445
genes like me logo Genes that share ontologies with CASP10: view
genes like me logo Genes that share phenotypes with CASP10: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CASP10 Gene

Localization for CASP10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASP10 Gene COMPARTMENTS Subcellular localization image for CASP10 gene
Compartment Confidence
cytosol 4
plasma membrane 4
mitochondrion 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane --
GO:0031265 CD95 death-inducing signaling complex IDA 11717445
GO:0097342 ripoptosome IDA 21737330
genes like me logo Genes that share ontologies with CASP10: view

Pathways for CASP10 Gene

genes like me logo Genes that share pathways with CASP10: view

Gene Ontology (GO) - Biological Process for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006915 apoptotic process TAS 10412980
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IBA --
GO:0007166 cell surface receptor signaling pathway TAS --
GO:0042981 regulation of apoptotic process --
genes like me logo Genes that share ontologies with CASP10: view

Compounds for CASP10 Gene

(12) ApexBio Compounds for CASP10 Gene

Compound Action Cas Number
Apoptosis Inhibitor Cell-permeable caspase-3 inhibitor [54135-60-3]
Caspase-3/7 Inhibitor I Cell-permeable and irreversible inhibitor of caspase-3 and -7 [220509-74-0]
Cisplatin Chemotherapy agent, induces apoptosis [15663-27-1]
PAC-1 Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3 [315183-21-2]
Q-VD-Oph Cell-permeable, irreversible pan-caspase inhibitor [1135695-98-5]
VX-765 Novel Caspase-1 inhibitor [273404-37-8]
Z-DEVD-FMK Cell-permeable, and irreversible caspase-3 inhibitor [210344-95-9]
Z-DQMD-FMK Cell-permeable caspase-3 inhibitor
Z-FA-FMK An inhibitor of cysteine proteases, such as cathepsin B.
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor [187389-52-2]
Z-VDVAD-FMK Cell-permeable and irreversible caspase-2 inhibitor
Z-VEID-FMK Cell-permeable and irreversible caspase-6 inhibitor

(5) Tocris Compounds for CASP10 Gene

Compound Action Cas Number
AZ 10417808 Selective non-peptide caspase-3 inhibitor [331645-84-2]
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 [15663-27-1]
Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor
Z-DQMD-FMK Caspase-3 inhibitor
Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

(4) Novoseek inferred chemical compound relationships for CASP10 Gene

Compound -log(P) Hits PubMed IDs
cysteine 32.4 3
paclitaxel 22 7
actinomycin d 6.07 1
serine 0 2
genes like me logo Genes that share compounds with CASP10: view

Transcripts for CASP10 Gene

Unigene Clusters for CASP10 Gene

Caspase 10, apoptosis-related cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10:
SP11: -

ExUns: 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CASP10 Gene

GeneLoc Exon Structure for
CASP10
ECgene alternative splicing isoforms for
CASP10

Expression for CASP10 Gene

mRNA expression in normal human tissues for CASP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP10 Gene

This gene is overexpressed in Whole Blood (6.3) and Spleen (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP10 Gene

SOURCE GeneReport for Unigene cluster for CASP10 Gene Hs.5353

mRNA Expression by UniProt/SwissProt for CASP10 Gene

Q92851-CASPA_HUMAN
Tissue specificity: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon
genes like me logo Genes that share expressions with CASP10: view

Orthologs for CASP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP10 36
  • 99.1 (n)
  • 98.27 (a)
CASP10 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CASP10 36
  • 81 (n)
  • 72.44 (a)
CASP10 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CASP10 37
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CASP10 37
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves CASP10 36
  • 55.22 (n)
  • 47.99 (a)
CASP10 37
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CASP10 37
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casp10 36
  • 53.88 (n)
  • 46.12 (a)
zebrafish
(Danio rerio)
Actinopterygii casp8l2 36
  • 47.51 (n)
  • 36.81 (a)
casp8l2 37
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dcp-1 37
  • 29 (a)
ManyToMany
decay 37
  • 28 (a)
ManyToMany
Ice 37
  • 28 (a)
ManyToMany
Species with no ortholog for CASP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP10 Gene

ENSEMBL:
Gene Tree for CASP10 (if available)
TreeFam:
Gene Tree for CASP10 (if available)

Paralogs for CASP10 Gene

Paralogs for CASP10 Gene

Selected SIMAP similar genes for CASP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CASP10: view

Variants for CASP10 Gene

Sequence variations from dbSNP and Humsavar for CASP10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1804650 -- 201,185,934(+) AGCTG(A/G)AGAAG missense, reference, utr-variant-5-prime
rs2881930 -- 201,211,029(+) TATAA(C/T)GATCA intron-variant
rs3731713 -- 201,196,103(-) GATAT(A/C)ATGTT intron-variant
rs3731714 -- 201,196,097(-) ATGTT(A/G)TTTAC intron-variant
rs3835915 -- 201,194,598(-) AGCTC(-/AT)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP10 Gene

Variant ID Type Subtype PubMed ID
nsv821874 CNV Loss 20364138

Relevant External Links for CASP10 Gene

HapMap Linkage Disequilibrium report
CASP10
Human Gene Mutation Database (HGMD)
CASP10
Locus Specific Mutation Databases (LSDB)
CASP10

Disorders for CASP10 Gene

(3) OMIM Diseases for CASP10 Gene (601762)

UniProtKB/Swiss-Prot

CASPA_HUMAN
  • Autoimmune lymphoproliferative syndrome 2A (ALPS2A) [MIM:603909]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269 PubMed:10412980, ECO:0000269 PubMed:16446975}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Familial non-Hodgkin lymphoma (NHL) [MIM:605027]: Cancer that starts in cells of the lymph system, which is part of the bodys immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. {ECO:0000269 PubMed:12010812}. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:11973654}. Note=The gene represented in this entry is involved in disease pathogenesis.

(1) University of Copenhagen DISEASES for CASP10 Gene

(21) Novoseek inferred disease relationships for CASP10 Gene

Disease -log(P) Hits PubMed IDs
autoimmune lymphoproliferative syndrome 90.4 8
autoimmune lymphoproliferative syndrome, type ii 88.7 2
necrosis 54.5 11
tumors 43.4 15
melanoma 32.1 3

Relevant External Links for CASP10

GeneTests
CASP10
GeneReviews
CASP10
Genetic Association Database (GAD)
CASP10
Human Genome Epidemiology (HuGE) Navigator
CASP10
genes like me logo Genes that share disorders with CASP10: view

Publications for CASP10 Gene

  1. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (PMID: 8755496) Fernandes-Alnemri T. … Alnemri E.S. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  2. Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma. (PMID: 18563783) Li C. … Wei Q. (Hum. Mutat. 2008) 3 4 23 49
  3. Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas. (PMID: 19900088) Kim M.S. … Lee S.H. (Pathology 2009) 3 4 23 49
  4. Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas. (PMID: 20025484) Oh J.E. … Yoo N.J. (Pathology 2010) 3 4 23
  5. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. (PMID: 8962078) Srinivasula S.M. … Alnemri E.S. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23

Products for CASP10 Gene

Sources for CASP10 Gene

Back to Top

Content