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Aliases for CASP10 Gene

Aliases for CASP10 Gene

  • Caspase 10 2 3 5
  • FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2 3 4
  • Caspase 10, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 10, Apoptosis-Related Cysteine Protease 2 3
  • ICE-Like Apoptotic Protease 4 3 4
  • CASP-10 3 4
  • FLICE2 3 4
  • MCH4 3 4
  • Caspase 10 Apoptosis-Related Cysteine Peptidase 3
  • Interleukin-1B-Converting Enzyme 2 3
  • Apoptotic Protease MCH-4 3
  • Apoptotic Protease Mch-4 4
  • FADD-Like ICE2 3
  • EC 3.4.22.63 4
  • ALPS2 3

External Ids for CASP10 Gene

Previous GeneCards Identifiers for CASP10 Gene

  • GC02P200264
  • GC02P200772
  • GC02P202011
  • GC02P202250
  • GC02P202223
  • GC02P201873
  • GC02P201756
  • GC02P202047
  • GC02P193898

Summaries for CASP10 Gene

Entrez Gene Summary for CASP10 Gene

  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

GeneCards Summary for CASP10 Gene

CASP10 (Caspase 10) is a Protein Coding gene. Diseases associated with CASP10 include autoimmune lymphoproliferative syndrome, type ii and lymphoma, non-hodgkin. Among its related pathways are Apoptosis Modulation and Signaling and Toll-like receptor signaling pathway. GO annotations related to this gene include ubiquitin protein ligase binding and cysteine-type peptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP10 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC.

  • Isoform C is proteolytically inactive.

Tocris Summary for CASP10 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Gene Wiki entry for CASP10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP10 Gene

Genomics for CASP10 Gene

Regulatory Elements for CASP10 Gene

Enhancers for CASP10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CASP10 on UCSC Golden Path with GeneCards custom track

Promoters for CASP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CASP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CASP10 Gene

Chromosome:
2
Start:
201,182,881 bp from pter
End:
201,229,406 bp from pter
Size:
46,526 bases
Orientation:
Plus strand

Genomic View for CASP10 Gene

Genes around CASP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP10 Gene

Proteins for CASP10 Gene

  • Protein details for CASP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92851-CASPA_HUMAN
    Recommended name:
    Caspase-10
    Protein Accession:
    Q92851
    Secondary Accessions:
    • Q68HC0
    • Q6KF62
    • Q6KF63
    • Q8IUP5
    • Q8WYQ8
    • Q99845
    • Q9Y2U6
    • Q9Y2U7

    Protein attributes for CASP10 Gene

    Size:
    521 amino acids
    Molecular mass:
    58951 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit (By similarity). Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Interacts with RFFL and RNF34; negatively regulate CASP10 through proteasomal degradation.

    Alternative splice isoforms for CASP10 Gene

neXtProt entry for CASP10 Gene

Proteomics data for CASP10 Gene at MOPED

Post-translational modifications for CASP10 Gene

  • Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
  • Ubiquitination at Lys 192 and Lys 271
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for CASP10

No data available for DME Specific Peptides for CASP10 Gene

Domains & Families for CASP10 Gene

Gene Families for CASP10 Gene

Suggested Antigen Peptide Sequences for CASP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q92851

UniProtKB/Swiss-Prot:

CASPA_HUMAN :
  • Contains 2 DED (death effector) domains.
  • Belongs to the peptidase C14A family.
Domain:
  • Contains 2 DED (death effector) domains.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP10: view

Function for CASP10 Gene

Molecular function for CASP10 Gene

GENATLAS Biochemistry:
caspase 10,cysteine containing aspartate-specific protease,expressed in fetal lung,kidney,skeletal muscle,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis,homolog to C elegans cell death gene Ced-3
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp- -Gly.
UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC.
UniProtKB/Swiss-Prot Function:
Isoform C is proteolytically inactive.

Enzyme Numbers (IUBMB) for CASP10 Gene

Gene Ontology (GO) - Molecular Function for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP 11717445
genes like me logo Genes that share ontologies with CASP10: view
genes like me logo Genes that share phenotypes with CASP10: view

Human Phenotype Ontology for CASP10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CASP10 Gene

Localization for CASP10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASP10 Gene COMPARTMENTS Subcellular localization image for CASP10 gene
Compartment Confidence
cytosol 5
plasma membrane 5
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097342 ripoptosome IDA 21737330
genes like me logo Genes that share ontologies with CASP10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CASP10 Gene

Pathways & Interactions for CASP10 Gene

genes like me logo Genes that share pathways with CASP10: view

SIGNOR curated interactions for CASP10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0030225 macrophage differentiation IBA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12884866
GO:0045087 innate immune response TAS --
GO:0097190 apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with CASP10: view

Drugs & Compounds for CASP10 Gene

(4) Drugs for CASP10 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(5) Additional Compounds for CASP10 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Calpeptin
117591-20-5
MG 132
133407-82-6
N-Acetyl-L-leucyl-L-leucyl-L-methional
136632-32-1
PD 150606
179528-45-1

(5) Tocris Compounds for CASP10 Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
N-Acetyl-L-leucyl-L-leucyl-L-methional Cathepsin inhibitor 136632-32-1
PD 150606 Cell permeable calpain inhibitor 179528-45-1
genes like me logo Genes that share compounds with CASP10: view

Transcripts for CASP10 Gene

Unigene Clusters for CASP10 Gene

Caspase 10, apoptosis-related cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10:
SP11: -

ExUns: 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CASP10 Gene

GeneLoc Exon Structure for
CASP10
ECgene alternative splicing isoforms for
CASP10

Expression for CASP10 Gene

mRNA expression in normal human tissues for CASP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP10 Gene

This gene is overexpressed in Whole Blood (x6.3) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for CASP10 Gene

This gene is overexpressed in Plasma (40.8) and Cervix (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP10 Gene



SOURCE GeneReport for Unigene cluster for CASP10 Gene Hs.5353

mRNA Expression by UniProt/SwissProt for CASP10 Gene

Q92851-CASPA_HUMAN
Tissue specificity: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
genes like me logo Genes that share expression patterns with CASP10: view

Protein tissue co-expression partners for CASP10 Gene

Primer Products

In Situ Assay Products

Orthologs for CASP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CASP10 35
  • 81 (n)
  • 72.44 (a)
CASP10 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CASP10 35
  • 99.1 (n)
  • 98.27 (a)
CASP10 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CASP10 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CASP10 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves CASP10 35
  • 55.22 (n)
  • 47.99 (a)
CASP10 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CASP10 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casp10 35
  • 53.88 (n)
  • 46.12 (a)
zebrafish
(Danio rerio)
Actinopterygii casp8l2 35
  • 47.51 (n)
  • 36.81 (a)
casp8l2 36
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dcp-1 36
  • 29 (a)
ManyToMany
decay 36
  • 28 (a)
ManyToMany
Ice 36
  • 28 (a)
ManyToMany
Species with no ortholog for CASP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP10 Gene

ENSEMBL:
Gene Tree for CASP10 (if available)
TreeFam:
Gene Tree for CASP10 (if available)

Paralogs for CASP10 Gene

Paralogs for CASP10 Gene

(1) SIMAP similar genes for CASP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CASP10: view

Variants for CASP10 Gene

Sequence variations from dbSNP and Humsavar for CASP10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17860403 Autoimmune lymphoproliferative syndrome 2A (ALPS2A) 201,208,114(+) GAGGC(C/T)TCTGT intron-variant, nc-transcript-variant, reference, missense
rs13010627 - 201,209,375(+) CTTCC(A/G)TATCC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs121909776 Gastric cancer (GASC) 201,187,798(+) TGAAA(C/T)GGTGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs80358239 Autoimmune lymphoproliferative syndrome 2A (ALPS2A) 201,209,363(+) AAGAG(A/C/T)TACAG downstream-variant-500B, reference, missense, utr-variant-3-prime
rs28936699 Familial non-Hodgkin lymphoma (NHL) 201,209,388(+) CGAAG(C/T)AGATG downstream-variant-500B, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CASP10 Gene

Variant ID Type Subtype PubMed ID
nsv821874 CNV Loss 20364138

Variation tolerance for CASP10 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASP10 Gene

HapMap Linkage Disequilibrium report
CASP10
Human Gene Mutation Database (HGMD)
CASP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP10 Gene

Disorders for CASP10 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CASP10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CASPA_HUMAN
  • Autoimmune lymphoproliferative syndrome 2A (ALPS2A) [MIM:603909]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269 PubMed:10412980, ECO:0000269 PubMed:16446975}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Familial non-Hodgkin lymphoma (NHL) [MIM:605027]: Cancer that starts in cells of the lymph system, which is part of the bodys immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. {ECO:0000269 PubMed:12010812}. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:11973654}. Note=The gene represented in this entry is involved in disease pathogenesis.

Relevant External Links for CASP10

Genetic Association Database (GAD)
CASP10
Human Genome Epidemiology (HuGE) Navigator
CASP10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASP10
genes like me logo Genes that share disorders with CASP10: view

No data available for Genatlas for CASP10 Gene

Publications for CASP10 Gene

  1. Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas. (PMID: 19900088) Kim M.S. … Lee S.H. (Pathology 2009) 3 4 23 48 67
  2. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (PMID: 8755496) Fernandes-Alnemri T. … Alnemri E.S. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 23
  3. Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas. (PMID: 20025484) Oh J.E. … Yoo N.J. (Pathology 2010) 3 23
  4. Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. (PMID: 19380486) Chen H. … Lu Z. (Mol. Cell. Biol. 2009) 3 23
  5. Caspase-dependent molecular mechanisms of anti-human DR5 monoclonal antibody mDRA-6 inducing apoptosis of human leukemia Jurkat cells. (PMID: 19550122) Du Y.W. … Ma Y.F. (Ai Zheng 2009) 3 23

Products for CASP10 Gene

Sources for CASP10 Gene

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