CASKIN2 Gene
protein-coding GIFtS: 48
GCID: GC17M073496
|
|
CASK interacting protein 2
| |
Aliases
for CASKIN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CASK Interacting Protein 21 2 | | KIAA11391 3 5 | | ANKS5B1 2 | | CASK-Interacting Protein 22 3 | | FLJ216091 | | Caskin-21 |
Export aliases for CASKIN2 gene to outside databasesPrevious GC identifers: GC00U990821 GC17M076522 GC17M073960 GC17M074093 GC17M071007 GC17M068919 |
Summaries
for CASKIN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CASKIN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CASKIN2 gene promoter:
NF-1/L Pax-6 HOXA5 HNF-4alpha2 Ik-1 C/EBPalpha HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CASKIN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASKIN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.2CASKIN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M073496: view genomic region
(about GC identifiers)
Start:
|
73,496,342 bp from pter |
End:
|
73,511,664 bp from pter |
Size:
|
15,323 bases |
Orientation:
|
minus strand |
|
Proteins
for CASKIN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CSKI2_HUMAN, Q8WXE0 (See
protein sequence)Recommended Name: Caskin-2 Size: 1202 amino acids; 126783 Da
Subunit: May not bind CASK
Subcellular location: Cytoplasm (By similarity)
1 PDB 3D structure from  and Proteopedia  for CASKIN2:2KE9 (3D)
Secondary accessions: B4DTT3 B7Z9H1 Q7LG69 Q9ULT1Alternative splicing: 2 isoforms: Q8WXE0-1 Q8WXE0-2 Explore the universe of human proteins at neXtProt for CASKIN2: NX_Q8WXE0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXE0
CASKIN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001136115.1 NP_065804.2
ENSEMBL proteins: ENSP00000325355 ENSP00000406963 ENSP00000464300 ENSP00000463211
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
CASKIN2 for ontologies About GeneDecksing
CASKIN2 Antibody Products:
Assay Products for CASKIN2: |
Protein
Domains /
Families
for CASKIN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CASKIN2 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q8WXE0ProtoNet protein and cluster: Q8WXE0 4 Blocks protein families: IPB001452 SH3 domain signature IPB001660 Sterile alpha motif SAM IPB002110 Ankyrin repeat signature IPB011511 Variant SH3
UniProtKB/Swiss-Prot: CSKI2_HUMAN, Q8WXE0Similarity: Contains 6 ANK repeatsSimilarity: Contains 2 SAM (sterile alpha motif) domainsSimilarity: Contains 1 SH3 domain |
Function
for CASKIN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASKIN2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASKIN2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASKIN2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
CASKIN2 for ontologies About GeneDecksing
|
Pathways & Interactions
for CASKIN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CASKIN2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for CASKIN2 (Q8WXE02, 3 ENSP000003253554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
CASKIN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CASKIN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CASKIN2
Search CenterWatch for drugs/clinical trials and news about CASKIN2 / CSKI2
|
Transcripts
for CASKIN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CASKIN2 gene (2 alternative transcripts): NM_001142643.1 NM_020753.3 Unigene Cluster for CASKIN2: CASK interacting protein 2 Hs.274408 [show with all ESTs]Unigene Representative Sequence: BC0666437 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321617(uc010wsc.2 uc002joc.3) ENST00000433559 ENST00000580021
ENST00000581870(uc002jod.3) ENST00000583258 ENST00000583246 ENST00000580075
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASKIN2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASKIN2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CASKIN2 (NM_001142643) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AB032965.1 AF451976.1 AK025262.1 AK300354.1 AK315936.1 BC032359.1 BC066643.1 4 DOTS entries: DT.97814321 DT.100818985 DT.91765253 DT.100038258 24/114 AceView cDNA sequences (see all 114): NM_020753 BG392360 BF530041 BG913088 BU624833 AI479679 BC066643 AA640137 BQ229696 AA586863 AI637753 AW005347 AB032965 BM716852 BM717363 BI011157 BI966142 BI966211 CK904068 CB216246 AA362564 BX117405 BE294747 AA300357
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CASKIN2 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CASKIN2
|
Expression
for CASKIN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CASKIN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATACACA
About this image
See CASKIN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CASKIN2
SOURCE GeneReport for Unigene cluster: Hs.274408
SABiosciences Custom PCR Arrays for CASKIN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASKIN2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASKIN2 |
Orthologs
for CASKIN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CASKIN2 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CASKIN21 |
CASK interacting protein 2 |
65.12(n)
62.92(a) |
|
422125 XM_420128.3 XP_420128.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CASKIN26 |
-- |
57(a) |
1 ↔ 1 |
2(114363327-114402517) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.22972 |
Xenopus laevis transcribed sequence with weak similarity more |
75.07(n) |
|
48023046 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.214602 |
Transcribed sequence with weak similarity to protein more |
76.9(n) |
|
57050370 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ckn6 |
caskin |
13(a) |
possible ortholog |
2R(10850819-10868089) |
worm
(Caenorhabditis elegans) |
Secernentea |
C46H3.36C46H3.26 |
Protein C46H3.2, isoform a |
27(a)16(a) |
1 ↔ manypossible ortholog |
X(1226219-1230755) X(1211754-1220024) |
ENSEMBL Gene Tree for CASKIN2 (if available)
TreeFam Gene Tree for CASKIN2 (if available) |
Paralogs
for CASKIN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CASKIN2 gene
- CASKIN12 ANKS1A2 ANKS1B2
14 SIMAP similar genes for CASKIN2 using alignment to 3 protein entries: CSKI2_HUMAN (see all proteins):OSBPL1A ANKS1A ANKRD12 KRIT1 ANKRD42 HACE1
RAI14 ANKRD6 ANKRD44 CDKN2C GABPB1 ANKRD65
FEM1B CASKIN1
CASKIN2 for paralogs About GeneDecksing
|
Genomic Variants
for CASKIN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CASKIN2 (73496342 - 73511664 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CASKIN2
2 CNVs: 49926 30023 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASKIN2 |
|
Disorders
/ Diseases
for CASKIN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CASKIN2 for disorders About MalaCards
CASKIN2 for disorders About GeneDecksing
OMIM gene information: 612185
OMIM disorders: --
Export disorders for CASKIN2 gene to outside databases
|
Publications
for CASKIN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CASKIN2 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CASKIN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with Caskin 1, a novel CASK-binding protein. (PubMed id 12040031)1, 2, 3 Tabuchi K.... Suedhof T.C. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- Error tolerant NMR backbone resonance assignment and automated structure generation. (PubMed id 21328705)2 Alipanahi B.... Li M. (2011)
- A human sterile alpha motif domain polymerizome. (PubMed id 21805519)1 Knight M.J....Bowie J.U. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. (PubMed id 19531213)1 Havrylov S....Redowicz M.J. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for CASKIN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CASKIN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CASKIN2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CASKIN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CASKIN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CASKIN2 gene:
Search GeneIP for patents involving CASKIN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CASKIN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
 |
 |
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| |
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| | | | Search Tocris compounds for CASKIN2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CASKIN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASKIN2 |
|  |  |  | | | | ThermoFisher Antibodies for CASKIN2 |
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