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Aliases for CASD1 Gene

Aliases for CASD1 Gene

  • CAS1 Domain Containing 1 2 3
  • C7orf12 3 4 6
  • Chromosome 7 Open Reading Frame 12 2
  • CAS1 Domain-Containing Protein 1 3
  • O-Acetyltransferase 3
  • WUGSC:H_GS542D18.2 3
  • NBLA04196 3

External Ids for CASD1 Gene

Previous GeneCards Identifiers for CASD1 Gene

  • GC07P093977
  • GC07P094139
  • GC07P088746

Summaries for CASD1 Gene

GeneCards Summary for CASD1 Gene

CASD1 (CAS1 Domain Containing 1) is a Protein Coding gene. Diseases associated with CASD1 include brachydactyly-syndactyly syndrome.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASD1 Gene

Genomics for CASD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CASD1 Gene

94,509,219 bp from pter
94,557,019 bp from pter
47,801 bases
Plus strand

Genomic View for CASD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASD1 Gene

No data available for Regulatory Elements for CASD1 Gene

Proteins for CASD1 Gene

  • Protein details for CASD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CAS1 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KW13
    • O14574
    • Q3LIE2
    • Q6P4R4
    • Q9H6T9
    • Q9H770

    Protein attributes for CASD1 Gene

    797 amino acids
    Molecular mass:
    91680 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB69978.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB15028.1; Type=Frameshift; Positions=780; Evidence={ECO:0000305}; Sequence=BAB15163.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15163.1; Type=Frameshift; Positions=543; Evidence={ECO:0000305};

neXtProt entry for CASD1 Gene

Proteomics data for CASD1 Gene at MOPED

Post-translational modifications for CASD1 Gene

  • Glycosylation at Asn141, Asn175, Asn187, and Asn241
  • Modification sites at PhosphoSitePlus

Other Protein References for CASD1 Gene

No data available for DME Specific Peptides for CASD1 Gene

Domains for CASD1 Gene

Protein Domains for CASD1 Gene

Suggested Antigen Peptide Sequences for CASD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96PB1
  • Belongs to the PC-esterase family. CASD1 subfamily.
genes like me logo Genes that share domains with CASD1: view

No data available for Gene Families for CASD1 Gene

Function for CASD1 Gene

Gene Ontology (GO) - Molecular Function for CASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CASD1: view

Animal Model Products

miRNA for CASD1 Gene

miRTarBase miRNAs that target CASD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CASD1 Gene

Localization for CASD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASD1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CASD1 Gene COMPARTMENTS Subcellular localization image for CASD1 gene
Compartment Confidence
plasma membrane 3
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CASD1: view

Pathways for CASD1 Gene

SuperPathways for CASD1 Gene

No Data Available

Interacting Proteins for CASD1 Gene

Gene Ontology (GO) - Biological Process for CASD1 Gene


No data available for Pathways by source for CASD1 Gene

Transcripts for CASD1 Gene

Unigene Clusters for CASD1 Gene

CAS1 domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASD1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASD1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - -
SP4: - -
SP5: - - - - - -

ExUns: 19 ^ 20

Relevant External Links for CASD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CASD1 Gene

mRNA expression in normal human tissues for CASD1 Gene

Protein differential expression in normal tissues for CASD1 Gene

This gene is overexpressed in Breast (59.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASD1 Gene

SOURCE GeneReport for Unigene cluster for CASD1 Gene Hs.260041

genes like me logo Genes that share expressions with CASD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for CASD1 Gene

Orthologs for CASD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CASD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CASD1 35
  • 95.32 (n)
  • 97.24 (a)
CASD1 36
  • 97 (a)
(Canis familiaris)
Mammalia CASD1 35
  • 94.96 (n)
  • 97.94 (a)
CASD1 36
  • 98 (a)
(Mus musculus)
Mammalia Casd1 35
  • 89.78 (n)
  • 94.97 (a)
Casd1 16
Casd1 36
  • 95 (a)
(Pan troglodytes)
Mammalia CASD1 35
  • 99.83 (n)
  • 99.87 (a)
CASD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC678772 35
  • 84.46 (n)
  • 88.66 (a)
(Monodelphis domestica)
Mammalia CASD1 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia CASD1 36
  • 80 (a)
(Gallus gallus)
Aves CASD1 35
  • 80.05 (n)
  • 84.57 (a)
CASD1 36
  • 86 (a)
(Anolis carolinensis)
Reptilia CASD1 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia casd1 35
  • 69.99 (n)
  • 72.8 (a)
(Danio rerio)
Actinopterygii casd1 35
  • 67.69 (n)
  • 71.92 (a)
casd1 36
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001402 35
  • 46.9 (n)
  • 40.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2938 35
  • 47.51 (n)
  • 38.74 (a)
CG2938 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34410 35
  • 48.18 (n)
  • 36.39 (a)
(Oryza sativa)
Liliopsida Os01g0631100 35
  • 49.67 (n)
  • 36.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13151 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for CASD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASD1 Gene

Gene Tree for CASD1 (if available)
Gene Tree for CASD1 (if available)

Paralogs for CASD1 Gene

Selected SIMAP similar genes for CASD1 Gene using alignment to 4 proteins: Pseudogenes for CASD1 Gene

genes like me logo Genes that share paralogs with CASD1: view

No data available for Paralogs for CASD1 Gene

Variants for CASD1 Gene

Sequence variations from dbSNP and Humsavar for CASD1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs15671 -- 94,556,752(+) TGGGC(A/C)ATAAA utr-variant-3-prime
rs17325 -- 94,535,526(-) TTTCT(C/T)ACAGT intron-variant
rs1056413 -- 94,536,848(+) TTGAA(A/G)GTTCT intron-variant
rs1133697 -- 94,556,578(+) TTCGT(A/C)TATTA utr-variant-3-prime
rs1133698 -- 94,556,698(+) TGTTA(C/T)GATTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CASD1 Gene

Variant ID Type Subtype PubMed ID
esv2422248 CNV Duplication 17116639

Relevant External Links for CASD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASD1 Gene

Disorders for CASD1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CASD1 Gene in MalaCards »

(1) Diseases for CASD1 Gene including...

(1) University of Copenhagen DISEASES for CASD1 Gene

genes like me logo Genes that share disorders with CASD1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for CASD1 Gene

Publications for CASD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Mutations in the gene encoding epsilon-sarcoglycan cause myoclonus- dystonia syndrome. (PMID: 11528394) Zimprich A. … Gasser T. (Nat. Genet. 2001) 2 3
  3. Cas1p is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide. (PMID: 11703667) Janbon G. … Dromer F. (Mol. Microbiol. 2001) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for CASD1 Gene

Sources for CASD1 Gene

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