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Aliases for CASC8 Gene

Subcategory (RNA class) for CASC8 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for CASC8 Gene

  • Cancer Susceptibility 8 (Non-Protein Coding) 2 3 5
  • Cancer Susceptibility Candidate 8 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 860 2 3
  • LINC00860 3
  • CARLo-1 3

External Ids for CASC8 Gene

Previous GeneCards Identifiers for CASC8 Gene

  • GC08M128304

Summaries for CASC8 Gene

GeneCards Summary for CASC8 Gene

CASC8 (Cancer Susceptibility 8 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC8 Gene

Genomics for CASC8 Gene

Regulatory Elements for CASC8 Gene

Enhancers for CASC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G127396 1.5 FANTOM5 ENCODE dbSUPER 20.4 +81.9 81863 7.1 FOXA2 ZNF133 ARID4B BMI1 RAD21 RARA ZNF207 CREM HMG20B CEBPB CASC8 MYC CCAT2 GC08M127382
GH08G127393 1.1 FANTOM5 ENCODE dbSUPER 20 +87.3 87309 2.4 MAFG ATF2 ZNF316 MAFF CREB1 NFE2 MAFK EMSY CASC8 CCAT2 GC08M127382
GH08G127426 0.8 Ensembl ENCODE 19.8 +55.0 55002 1.8 PKNOX1 NONO ZNF207 CEBPG HES1 CASC8 POU5F1B
GH08G127389 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.1 +90.5 90479 3.3 TBP CTCF TAF1 JUN MAX CEBPB NR3C1 EP300 FOSL1 JUND CASC8 MYC GC08M127382 CCAT2
GH08G127034 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5 +445.2 445214 4.9 HDGF FOXA2 PKNOX1 ARNT SIN3A YY1 ZNF766 ZNF143 FOS KLF13 CASC8 PRNCR1 PIR56595
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CASC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CASC8 Gene

Chromosome:
8
Start:
127,289,676 bp from pter
End:
127,482,139 bp from pter
Size:
192,464 bases
Orientation:
Minus strand

Genomic View for CASC8 Gene

Genes around CASC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC8 Gene

Proteins for CASC8 Gene

Post-translational modifications for CASC8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CASC8 Gene

Domains & Families for CASC8 Gene

Gene Families for CASC8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CASC8: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CASC8 Gene

Function for CASC8 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CASC8 Gene

Localization for CASC8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CASC8 Gene

Pathways & Interactions for CASC8 Gene

SuperPathways for CASC8 Gene

No Data Available

Interacting Proteins for CASC8 Gene

Gene Ontology (GO) - Biological Process for CASC8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CASC8 Gene

Drugs & Compounds for CASC8 Gene

No Compound Related Data Available

Transcripts for CASC8 Gene

mRNA/cDNA for CASC8 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CASC8 Gene

No ASD Table

Relevant External Links for CASC8 Gene

GeneLoc Exon Structure for
CASC8
ECgene alternative splicing isoforms for
CASC8

Expression for CASC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CASC8 Gene

mRNA differential expression in normal tissues according to GTEx for CASC8 Gene

This gene is overexpressed in Minor Salivary Gland (x7.6), Colon - Transverse (x5.0), and Esophagus - Mucosa (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of CASC8 Gene:

CASC8
genes like me logo Genes that share expression patterns with CASC8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASC8 Gene

Orthologs for CASC8 Gene

Evolution for CASC8 Gene

ENSEMBL:
Gene Tree for CASC8 (if available)
TreeFam:
Gene Tree for CASC8 (if available)

No data available for Orthologs for CASC8 Gene

Paralogs for CASC8 Gene

No data available for Paralogs for CASC8 Gene

Variants for CASC8 Gene

Sequence variations from dbSNP and Humsavar for CASC8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000023795 -- 127,294,815(+) AGCCT(A/T)CATCT intron-variant
rs1000032748 -- 127,339,738(+) CAGCT(C/T)ACGGG intron-variant
rs1000055146 -- 127,295,151(+) GTGAG(G/T)GCACA intron-variant
rs1000073782 -- 127,458,508(+) AAAAT(A/G)GAGTA intron-variant
rs1000084230 -- 127,428,766(+) AAGCT(A/G)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASC8 Gene

Variant ID Type Subtype PubMed ID
esv1008397 CNV deletion 20482838
esv1217766 CNV deletion 17803354
esv1960296 CNV deletion 18987734
esv2737564 CNV deletion 23290073
esv2737565 CNV deletion 23290073
esv2737566 CNV deletion 23290073
esv275357 CNV loss 21479260
esv3321908 CNV insertion 20981092
esv3392005 CNV insertion 20981092
esv3395895 CNV insertion 20981092
esv3618771 CNV loss 21293372
nsv1075579 CNV deletion 25765185
nsv1112476 CNV deletion 24896259
nsv1126860 CNV deletion 24896259
nsv1152103 CNV deletion 26484159
nsv472662 CNV novel sequence insertion 20440878
nsv499795 OTHER inversion 21111241
nsv511384 CNV loss 21212237
nsv7419 OTHER inversion 18451855
nsv951468 CNV duplication 24416366
nsv958462 CNV deletion 24416366
nsv981980 CNV duplication 23825009

Relevant External Links for CASC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CASC8 Gene

Disorders for CASC8 Gene

Relevant External Links for CASC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASC8

No disorders were found for CASC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASC8 Gene

Publications for CASC8 Gene

  1. Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. (PMID: 24594601) Kim T. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2014) 2 3 64
  2. Genetic variant in 8q24 is associated with prognosis for gastric cancer in a Chinese population. (PMID: 25302443) Ma G. … Chen J. (J. Gastroenterol. Hepatol. 2015) 3 64
  3. Correlation Between CASC8, SMAD7 Polymorphisms and the Susceptibility to Colorectal Cancer: An Updated Meta-Analysis Based on GWAS Results. (PMID: 26579801) Yao K. … Hu J. (Medicine (Baltimore) 2015) 3 64
  4. Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. (PMID: 24753544) Knipe D.W. … Martin R.M. (Cancer Epidemiol. Biomarkers Prev. 2014) 3 64
  5. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. (PMID: 19767754) Gudmundsson J. … Stefansson K. (Nat. Genet. 2009) 3 64

Products for CASC8 Gene

Sources for CASC8 Gene

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