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Aliases for CASC4 Gene

Aliases for CASC4 Gene

  • Cancer Susceptibility Candidate 4 2 3 5
  • Cancer Susceptibility Candidate Gene 4 Protein 3 4
  • Gene Associated With HER-2/Neu Overexpression 3
  • Protein CASC4 3
  • H63 3

External Ids for CASC4 Gene

Previous GeneCards Identifiers for CASC4 Gene

  • GC15P042369
  • GC15P044580
  • GC15P021404

Summaries for CASC4 Gene

Entrez Gene Summary for CASC4 Gene

  • The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CASC4 Gene

CASC4 (Cancer Susceptibility Candidate 4) is a Protein Coding gene. An important paralog of this gene is GOLM1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC4 Gene

Genomics for CASC4 Gene

Regulatory Elements for CASC4 Gene

Enhancers for CASC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CASC4 on UCSC Golden Path with GeneCards custom track

Promoters for CASC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CASC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CASC4 Gene

44,288,616 bp from pter
44,415,761 bp from pter
127,146 bases
Plus strand

Genomic View for CASC4 Gene

Genes around CASC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC4 Gene

Proteins for CASC4 Gene

  • Protein details for CASC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein CASC4
    Protein Accession:
    Secondary Accessions:
    • B4DPZ6
    • G5E934
    • Q6UY45
    • Q96EM1

    Protein attributes for CASC4 Gene

    433 amino acids
    Molecular mass:
    48864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC4 Gene


neXtProt entry for CASC4 Gene

Post-translational modifications for CASC4 Gene

  • Glycosylation at Asn 115, Asn 150, Thr 195, Ser 233, Thr 345, and Ser 366
  • Modification sites at PhosphoSitePlus

Other Protein References for CASC4 Gene

No data available for DME Specific Peptides for CASC4 Gene

Domains & Families for CASC4 Gene

Protein Domains for CASC4 Gene


Suggested Antigen Peptide Sequences for CASC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GOLM1/CASC4 family.
  • Belongs to the GOLM1/CASC4 family.
genes like me logo Genes that share domains with CASC4: view

No data available for Gene Families for CASC4 Gene

Function for CASC4 Gene

genes like me logo Genes that share phenotypes with CASC4: view

Animal Models for CASC4 Gene

MGI Knock Outs for CASC4:

Animal Model Products

  • Taconic Biosciences Mouse Models for CASC4

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CASC4 Gene

Localization for CASC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASC4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CASC4 Gene COMPARTMENTS Subcellular localization image for CASC4 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CASC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CASC4: view

Pathways & Interactions for CASC4 Gene

SuperPathways for CASC4 Gene

No Data Available

Interacting Proteins for CASC4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000299957 Q6P4E1-CASC4_HUMAN for CASC4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CASC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for CASC4 Gene

Drugs & Compounds for CASC4 Gene

No Compound Related Data Available

Transcripts for CASC4 Gene

Unigene Clusters for CASC4 Gene

Cancer susceptibility candidate 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASC4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP2: - - -
SP3: -

Relevant External Links for CASC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CASC4 Gene

mRNA expression in normal human tissues for CASC4 Gene

Protein differential expression in normal tissues from HIPED for CASC4 Gene

This gene is overexpressed in Nasal epithelium (56.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CASC4 Gene

Protein tissue co-expression partners for CASC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CASC4 Gene:


SOURCE GeneReport for Unigene cluster for CASC4 Gene:

genes like me logo Genes that share expression patterns with CASC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CASC4 Gene

Orthologs for CASC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CASC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CASC4 34
  • 89.11 (n)
  • 87.09 (a)
CASC4 35
  • 88 (a)
(Canis familiaris)
Mammalia CASC4 34
  • 92.35 (n)
  • 91.28 (a)
CASC4 35
  • 91 (a)
(Mus musculus)
Mammalia Casc4 34
  • 90.65 (n)
  • 89.89 (a)
Casc4 16
Casc4 35
  • 90 (a)
(Pan troglodytes)
Mammalia CASC4 34
  • 98.25 (n)
  • 97.63 (a)
CASC4 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Casc4 34
  • 89.96 (n)
  • 89.43 (a)
(Monodelphis domestica)
Mammalia CASC4 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
-- 35
  • 46 (a)
(Gallus gallus)
Aves CASC4 34
  • 71.46 (n)
  • 61.21 (a)
CASC4 35
  • 58 (a)
(Anolis carolinensis)
Reptilia CASC4 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia casc4 34
  • 62.78 (n)
  • 57.03 (a)
Str.9557 34
(Danio rerio)
Actinopterygii casc4 34
  • 61.84 (n)
  • 55.82 (a)
casc4 35
  • 45 (a)
Species where no ortholog for CASC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASC4 Gene

Gene Tree for CASC4 (if available)
Gene Tree for CASC4 (if available)

Paralogs for CASC4 Gene

Paralogs for CASC4 Gene Pseudogenes for CASC4 Gene

genes like me logo Genes that share paralogs with CASC4: view

Variants for CASC4 Gene

Sequence variations from dbSNP and Humsavar for CASC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2899113 -- 44,352,677(+) GAGGC(C/T)GGCAG intron-variant
rs3784564 -- 44,322,889(+) CAAGC(G/T)CAAAG intron-variant
rs3986148 -- 44,369,724(+) ACACA(-/CA/CACACATA)TATAT intron-variant
rs4924746 -- 44,318,444(+) tggct(C/T)acgcc intron-variant
rs11541697 -- 44,414,104(+) GTGCT(G/T)GAATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CASC4 Gene

Variant ID Type Subtype PubMed ID
dgv2587n100 CNV gain 25217958
dgv4510n54 CNV loss 21841781
esv3636306 CNV loss 21293372
esv3636307 CNV loss 21293372
nsv1122957 CNV deletion 24896259
nsv1134442 CNV deletion 24896259
nsv1139630 CNV duplication 24896259
nsv977705 CNV duplication 23825009

Variation tolerance for CASC4 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASC4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASC4 Gene

Disorders for CASC4 Gene

Relevant External Links for CASC4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CASC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASC4 Gene

Publications for CASC4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  3. Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PMID: 10497265) Oh J.J. … Slamon D.J. (Nucleic Acids Res. 1999) 2 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65

Products for CASC4 Gene

Sources for CASC4 Gene