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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CASC4 Gene

protein-coding GIFtS: 47
GCID: GC15P044580

cancer susceptibility candidate 4

Explore 4 diseases affiliated with
CASC4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cancer Susceptibility Candidate 4¹ ²
H63¹ ²
Cancer Susceptibility Candidate Gene 4 Protein² ³
DKFZp459F1927¹
Gene Associated With HER-2/Neu Overexpression²
Protein CASC4²

External Ids:	HGNC: 24892¹	Entrez Gene: 113201²	Ensembl: ENSG00000166734⁷	UniProtKB: Q6P4E1³

Export aliases for CASC4 gene to outside databases

Previous GC identifers: GC15P042369 GC15P021404

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CASC4:

The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification

and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human

ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene.

(provided by RefSeq, Dec 2010)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CASC4 gene promoter:
NF-1 RP58 AP-4 HNF-3beta Gfi-1 E2F E2F-1 Chx10 Msx-1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CASC4 promoter sequence

Search SABiosciences Chromatin IP Primers for CASC4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3 Ensembl cytogenetic band: 15q15.3 HGNC cytogenetic band: 15q15.1

CASC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASC4 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P044580: view genomic region (about GC identifiers)

Start:	44,580,927 bp from pter	End:	44,707,956 bp from pter
Size:	127,030 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CASC4_HUMAN, Q6P4E1 (See protein sequence)

Recommended Name: Protein CASC4

Size: 433 amino acids; 48864 Da

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

Secondary accessions: G5E934 Q6UY45 Q96EM1

Alternative splicing: 4 isoforms: Q6P4E1-1 Q6P4E1-2 Q6P4E1-3 Q6P4E1-4 (No experimental confirmation available. Ref.2 (AL832333) sequence is in conflict in position: 429:K->E)

Explore the universe of human proteins at neXtProt for CASC4: NX_Q6P4E1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6P4E1

CASC4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_612432.2 NP_816929.1

ENSEMBL proteins:

ENSP00000453703 ENSP00000453720 ENSP00000299957 ENSP00000452807 ENSP00000335063

ENSP00000453850 ENSP00000453465 ENSP00000452833 ENSP00000354067

Human Recombinant Protein Products:

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	Novus Biologicals CASC4 Protein Novus Biologicals CASC4 Lysate
	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for CASC4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

CASC4 for ontologies About GeneDecksing

CASC4 Antibody Products:

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	Uscn Antibodies for CASC4
	ThermoFisher Antibodies for CASC4

Assay Products for CASC4:

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	Uscn ELISAs and CLIAs for CASC4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CASC4 for domains About GeneDecksing

2 InterPro domains/families:

IPR026139 GOLM1/CASC4

IPR026141 CASC4

Graphical View of Domain Structure for InterPro Entry Q6P4E1

ProtoNet protein and cluster: Q6P4E1

UniProtKB/Swiss-Prot: CASC4_HUMAN, Q6P4E1

Similarity: Belongs to the GOLM1/CASC4 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CASC4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASC4
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CASC4 (see all 60):
		hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-1914* hsa-miR-200a

		SwitchGear 3'UTR luciferase reporter plasmid: CASC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASC4 (see all 3) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASC4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CASC4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): CASC4 (NM_138423)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASC4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CASC4
		Search LifeMap BioReagents cell lines for CASC4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASC4

Animal Models:
1 MGI phenotypic allele

for Casc4 (no phenotypes)

CASC4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CASC4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for CASC4 (Q6P4E1³ ENSP00000299957⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VDR	P11473³	I2D: score=2
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CASC4
Search CenterWatch for drugs/clinical trials and news about CASC4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CASC4 gene (2 alternative transcripts):

NM_138423.3 NM_177974.2

Unigene Cluster for CASC4:

Cancer susceptibility candidate 4

Hs.512867 [show with all ESTs]

Unigene Representative Sequence: NM_138423

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000559222 ENST00000557945(uc010bdu.2) ENST00000299957(uc001ztp.3 uc001ztq.3)

ENST00000429162 ENST00000561459(uc001zto.2) ENST00000345795 ENST00000558735

ENST00000559037 ENST00000558847 ENST00000559550 ENST00000561305 ENST00000559151

ENST00000360824

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CASC4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASC4
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CASC4 (see all 60):
		hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-1914* hsa-miR-200a

		SwitchGear 3'UTR luciferase reporter plasmid: CASC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASC4 (see all 3) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASC4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASC4 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASC4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CASC4 (NM_138423)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASC4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASC4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CASC4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASC4

Additional cDNA sequence:

AF103804.1 AK022565.1 AK095068.1 AK098265.1 AK291026.1 AK298564.1 AL832333.1 AL832840.1

AY358086.1 BC012124.1 BC041786.1 BC063480.1

14 DOTS entries:

DT.100028397 DT.217119 DT.101982810 DT.100795219 DT.121030642 DT.121030663 DT.120783245 DT.100795220

DT.121030699 DT.120778864 DT.40270389 DT.91967557 DT.100795226 DT.95320643

24/277 AceView cDNA sequences (see all 277):

BM981956 AA418825 CA391739 AA630340 BG433320 BQ574299 AA418922 AL832333

AA748880 AI753548 AI090252 AW025613 AA281049 BF034983 AA810852 BU742749

CA391738 BC063480 NM_177974 BU617831 AL119010 AA721278 AA651902 BC012124

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CASC4 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12
SP1:
SP2:																							-		-		-
SP3:									-
SP4:

ECgene alternative splicing isoforms for CASC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CASC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATTACCTG

About this image

CASC4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CASC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CASC4

SOURCE GeneReport for Unigene cluster: Hs.512867

SABiosciences Custom PCR Arrays for CASC4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASC4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CASC4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASC4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASC4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CASC4 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Casc4^{1 , 5}	cancer susceptibility candidate 4^{1, 5}	90.88(n)¹ 90.55(a)¹		2 (60.43 cM)⁵ 319996¹ NM_177054.5¹ NP_796028.2¹ 121866970⁵
chicken (Gallus gallus)	Aves	CASC4¹	cancer susceptibility candidate 4	71.36(n) 61.21(a)		415575 NM_001030556.1 NP_001025727.1
lizard (Anolis carolinensis)	Reptilia	CASC4⁶	--	63(a)	1 ↔ 1	GL343795.1(46293-60562)
African clawed frog (Xenopus laevis)	Amphibia	BJ070790.1²	--	74.91(n)		BJ070790.1
zebrafish (Danio rerio)	Actinopterygii	casc4¹	cancer susceptibility candidate 4	53.87(n) 43.28(a)		555654 XM_678225.4 XP_683317.2

ENSEMBL Gene Tree for CASC4 (if available)
TreeFam Gene Tree for CASC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CASC4 gene

GOLM1²

18/24 SIMAP similar genes for CASC4 using alignment to 6 protein entries: CASC4_HUMAN (see all proteins) (see all similar genes):

AVGR8 DUSP11 KIAA0101 LDLRAD3 SEPSECS pp12301

HC6 AAMDC CATSPERD COQ5 FP6778 DYNC2LI1

PPP5D1 C4BPB NCKAP1L GOLM1 GOLPH2 CCDC122

CASC4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CASC4
PGOHUM00000248312

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80329526^1,2	C,F,	--	44578980(+)	`TTTTGT/CACAAT`	2	--	us2k¹		1		NA	120
rs147066013^1,2		--	44579048(+)	`CTTAAC/GTAGTT`	2	--	us2k¹		0	--	--	--	--
rs147682908^1,2		--	44579227(+)	`ACCGCA/GCCCGG`	2	--	us2k¹		0	--	--	--	--
rs192739665^1,2		--	44579313(+)	`CTTTAA/TAGTTA`	2	--	us2k¹		0	--	--	--	--
rs149139105^1,2		--	44579510(+)	`TTCTAC/TGCTAC`	2	--	us2k¹		0	--	--	--	--
rs78623902^1,2	F	--	44579554(+)	`GAAGCC/ACAGAA`	2	--	us2k¹		1		NA	4
rs117415569^1,2	F,	--	44579742(+)	`CTCTAT/GGCACG`	2	--	us2k¹		1		NA	120
rs146273890^1,2		--	44579787(+)	`GTTTT-/GGTTTT`	2	--	us2k¹		0	--	--	--	--
rs143234658^1,2		--	44579849(+)	`GCAGAC/TAGCAC`	2	--	us2k¹		0	--	--	--	--
rs8037395^1,2	C,F,A,H,	--	44579854(+)	`CAGCAC/ATGGTG`	2	--	us2k¹		21		NS EA NA WA	2664

HapMap Linkage Disequilibrium report for CASC4 (44580927 - 44707956 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CASC4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASC4

DNA2.0 Custom Variant and Variant Library Synthesis for CASC4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CASC4 for disorders About GeneDecksing

4 diseases for CASC4: About MalaCards

soft tissue sarcoma ovarian cancer sarcoma breast cancer

1 disease from the University of Copenhagen DISEASES database for CASC4:

Alcohol dependence

Export disorders for CASC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CASC4 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CASC4)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PubMed id 10497265)^{1, 3} Oh J.J.... Slamon D.J. (1999)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Automated yeast two-hybrid screening for nuclear rece ptor-interacting proteins. (PubMed id 15604093)¹ Albers M....Koegl M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 113201	HGNC: 24892	AceView: H63	Ensembl:ENSG00000166734	euGenes: HUgn113201
ECgene: CASC4	H-InvDB: CASC4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CASC4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CASC4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CASC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CASC4 gene:
Search GeneIP for patents involving CASC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASC4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASC4
	OriGene Protein Over-expression Lysate for CASC4		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for CASC4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASC4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASC4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CASC4		OriGene Custom Protein Services for CASC4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CASC4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASC4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASC4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASC4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASC4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASC4

	GenScript Custom Purified and Recombinant Proteins Services for CASC4		GenScript cDNA clones with any tag delivered in your preferred vector for CASC4
	GenScript Custom Assay Services for CASC4		GenScript Custom Superior Antibodies Services for CASC4
	GenScript Custom overexpressing Cell Line Services for CASC4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in CASC4 promoter
	Search Chromatin IP Primers for CASC4
	RT² qPCR Primer Assay in human, mouse, rat CASC4
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CASC4 proteins
	CASC4 lysates

	Search for Antibodies for CASC4 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CASC4
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Browse ProSpec Recombinant Proteins

CASC4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CASC4

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASC4

	SwitchGear 3'UTR luciferase reporter plasmids for CASC4
	SwitchGear Promoter luciferase reporter plasmids for CASC4

ThermoFisher Antibodies for CASC4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASC4

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CASC4 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

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Export list of displayed genes

CASC4 Gene

cancer susceptibility candidate 4

Aliases
for CASC4 gene

Summaries
for CASC4 gene

Genomic Views
for CASC4 gene

Proteins
for CASC4 gene

Protein Domains /
Families
for CASC4 gene

Function
for CASC4 gene

Pathways & Interactions
for CASC4 gene

Drugs & Compounds
for CASC4 gene

Transcripts
for CASC4 gene

Expression
for CASC4 gene

Orthologs
for CASC4 gene

Paralogs
for CASC4 gene

Genomic Variants
for CASC4 gene

Disorders / Diseases
for CASC4 gene

Publications
for CASC4 gene

External Searches for CASC4 gene

Genome Databases showing CASC4 gene

Other Databases showing CASC4 gene

Specialized Databases showing CASC4 gene

Intellectual Property
for CASC4 gene

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Export list of displayed genes

CASC4 Gene

cancer susceptibility candidate 4

Aliasesfor CASC4 gene

Summariesfor CASC4 gene

Genomic Viewsfor CASC4 gene

Proteinsfor CASC4 gene

Protein Domains /Familiesfor CASC4 gene

Functionfor CASC4 gene

Pathways & Interactionsfor CASC4 gene

Drugs & Compoundsfor CASC4 gene

Transcriptsfor CASC4 gene

Expression for CASC4 gene

Orthologsfor CASC4 gene

Paralogsfor CASC4 gene

Genomic Variantsfor CASC4 gene

Disorders / Diseasesfor CASC4 gene

Publicationsfor CASC4 gene

External Searches for CASC4 gene

Genome Databases showing CASC4 gene

Other Databases showing CASC4 gene

Specialized Databases showing CASC4 gene

Intellectual Propertyfor CASC4 gene

Productsfor CASC4 gene

View Random Gene

Aliases
for CASC4 gene

Summaries
for CASC4 gene

Genomic Views
for CASC4 gene

Proteins
for CASC4 gene

Protein Domains /
Families
for CASC4 gene

Function
for CASC4 gene

Pathways & Interactions
for CASC4 gene

Drugs & Compounds
for CASC4 gene

Transcripts
for CASC4 gene

Expression
for CASC4 gene

Orthologs
for CASC4 gene

Paralogs
for CASC4 gene

Genomic Variants
for CASC4 gene

Disorders / Diseases
for CASC4 gene

Publications
for CASC4 gene

Intellectual Property
for CASC4 gene

Products
for CASC4 gene