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Aliases for CASC4 Gene

Aliases for CASC4 Gene

  • Cancer Susceptibility Candidate 4 2 3 5
  • Cancer Susceptibility Candidate Gene 4 Protein 3 4
  • Gene Associated With HER-2/Neu Overexpression 3
  • H63 3

External Ids for CASC4 Gene

Previous GeneCards Identifiers for CASC4 Gene

  • GC15P042369
  • GC15P044580
  • GC15P021404

Summaries for CASC4 Gene

Entrez Gene Summary for CASC4 Gene

  • The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CASC4 Gene

CASC4 (Cancer Susceptibility Candidate 4) is a Protein Coding gene. An important paralog of this gene is GOLM1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC4 Gene

Genomics for CASC4 Gene

Regulatory Elements for CASC4 Gene

Enhancers for CASC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CASC4 on UCSC Golden Path with GeneCards custom track

Promoters for CASC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CASC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CASC4 Gene

Chromosome:
15
Start:
44,288,616 bp from pter
End:
44,415,761 bp from pter
Size:
127,146 bases
Orientation:
Plus strand

Genomic View for CASC4 Gene

Genes around CASC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC4 Gene

Proteins for CASC4 Gene

  • Protein details for CASC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4E1-CASC4_HUMAN
    Recommended name:
    Protein CASC4
    Protein Accession:
    Q6P4E1
    Secondary Accessions:
    • B4DPZ6
    • G5E934
    • Q6UY45
    • Q96EM1

    Protein attributes for CASC4 Gene

    Size:
    433 amino acids
    Molecular mass:
    48864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASC4 Gene

Proteomics data for CASC4 Gene at MOPED

Post-translational modifications for CASC4 Gene

  • Glycosylation at Asn 115, Asn 150, Thr 195, Ser 233, Thr 345, and Ser 366
  • Modification sites at PhosphoSitePlus

Other Protein References for CASC4 Gene

No data available for DME Specific Peptides for CASC4 Gene

Domains & Families for CASC4 Gene

Protein Domains for CASC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CASC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P4E1

UniProtKB/Swiss-Prot:

CASC4_HUMAN :
  • Belongs to the GOLM1/CASC4 family.
Family:
  • Belongs to the GOLM1/CASC4 family.
genes like me logo Genes that share domains with CASC4: view

No data available for Gene Families for CASC4 Gene

Function for CASC4 Gene

Phenotypes for CASC4 Gene

genes like me logo Genes that share phenotypes with CASC4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CASC4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASC4 Gene

Localization for CASC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASC4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASC4 Gene COMPARTMENTS Subcellular localization image for CASC4 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CASC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CASC4: view

Pathways & Interactions for CASC4 Gene

SuperPathways for CASC4 Gene

No Data Available

Interacting Proteins for CASC4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299957%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000299957 Q6P4E1-CASC4_HUMAN for CASC4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CASC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CASC4 Gene

Drugs & Compounds for CASC4 Gene

No Compound Related Data Available

Transcripts for CASC4 Gene

Unigene Clusters for CASC4 Gene

Cancer susceptibility candidate 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASC4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1:
SP2: - - -
SP3: -
SP4:

Relevant External Links for CASC4 Gene

GeneLoc Exon Structure for
CASC4
ECgene alternative splicing isoforms for
CASC4

Expression for CASC4 Gene

mRNA expression in normal human tissues for CASC4 Gene

Protein differential expression in normal tissues from HIPED for CASC4 Gene

This gene is overexpressed in Nasal epithelium (56.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CASC4 Gene



SOURCE GeneReport for Unigene cluster for CASC4 Gene Hs.512867

genes like me logo Genes that share expression patterns with CASC4: view

Protein tissue co-expression partners for CASC4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CASC4 Gene

Orthologs for CASC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CASC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CASC4 35
  • 89.11 (n)
  • 87.09 (a)
CASC4 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CASC4 35
  • 92.35 (n)
  • 91.28 (a)
CASC4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Casc4 35
  • 90.65 (n)
  • 89.89 (a)
Casc4 16
Casc4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CASC4 35
  • 98.25 (n)
  • 97.63 (a)
CASC4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casc4 35
  • 89.96 (n)
  • 89.43 (a)
oppossum
(Monodelphis domestica)
Mammalia CASC4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves CASC4 35
  • 71.46 (n)
  • 61.21 (a)
CASC4 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CASC4 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casc4 35
  • 62.78 (n)
  • 57.03 (a)
Str.9557 35
zebrafish
(Danio rerio)
Actinopterygii casc4 35
  • 61.84 (n)
  • 55.82 (a)
casc4 36
  • 45 (a)
OneToOne
Species with no ortholog for CASC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASC4 Gene

ENSEMBL:
Gene Tree for CASC4 (if available)
TreeFam:
Gene Tree for CASC4 (if available)

Paralogs for CASC4 Gene

Paralogs for CASC4 Gene

Pseudogenes.org Pseudogenes for CASC4 Gene

genes like me logo Genes that share paralogs with CASC4: view

Variants for CASC4 Gene

Sequence variations from dbSNP and Humsavar for CASC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs4924746 -- 44,318,444(+) tggct(C/T)acgcc intron-variant
rs6493104 -- 44,288,419(+) GCGAG(A/C)GAGAG upstream-variant-2KB
rs6493105 -- 44,288,535(+) gagag(A/C)gagag upstream-variant-2KB
rs11856569 -- 44,382,642(+) TCTAA(A/C)CTTAT intron-variant
rs12148618 -- 44,322,486(+) GTTAC(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASC4 Gene

Variant ID Type Subtype PubMed ID
nsv904177 CNV Loss 21882294
nsv904178 CNV Loss 21882294
nsv904179 CNV Gain 21882294

Variation tolerance for CASC4 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASC4 Gene

Human Gene Mutation Database (HGMD)
CASC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASC4 Gene

Disorders for CASC4 Gene

Relevant External Links for CASC4

Genetic Association Database (GAD)
CASC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASC4

No disorders were found for CASC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASC4 Gene

Publications for CASC4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PMID: 10497265) Oh J.J. … Slamon D.J. (Nucleic Acids Res. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for CASC4 Gene

Sources for CASC4 Gene

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