Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CASC4 Gene

protein-coding   GIFtS: 49
GCID: GC15P044580

Cancer Susceptibility Candidate 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cancer Susceptibility Candidate 41 2
Cancer Susceptibility Candidate Gene 4 Protein2 3
H632
Gene Associated With HER-2/Neu Overexpression2
Protein CASC42

External Ids:    HGNC: 248921   Entrez Gene: 1132012   Ensembl: ENSG000001667347   UniProtKB: Q6P4E13   

Export aliases for CASC4 gene to outside databases

Previous GC identifers: GC15P042369 GC15P021404


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CASC4 Gene:
The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression.
Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast
and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified
for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for CASC4 Gene: 
CASC4 (cancer susceptibility candidate 4) is a protein-coding gene. Diseases associated with CASC4 include ovarian cancer, and soft tissue sarcoma. An important paralog of this gene is GOLM1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CASC4 gene promoter:
         NF-1   RP58   AP-4   HNF-3beta   Gfi-1   E2F   E2F-1   Chx10   Msx-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CASC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CASC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15.1

CASC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASC4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P044580:  view genomic region     (about GC identifiers)

Start:
44,580,909 bp from pter      End:
44,707,959 bp from pter
Size:
127,051 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CASC4_HUMAN, Q6P4E1 (See protein sequence)
Recommended Name: Protein CASC4  
Size: 433 amino acids; 48864 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: G5E934 Q6UY45 Q96EM1
Alternative splicing: 4 isoforms:  Q6P4E1-1   Q6P4E1-2   Q6P4E1-3   Q6P4E1-4   (No experimental confirmation available. Ref.2 (AL832333) sequence is in conflict in position: 429:K->E)

Explore the universe of human proteins at neXtProt for CASC4: NX_Q6P4E1

Explore proteomics data for CASC4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P4E1

  • CASC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CASC4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_612432.2  NP_816929.1  

    ENSEMBL proteins: 
     ENSP00000453703   ENSP00000453720   ENSP00000299957   ENSP00000335063   ENSP00000453850  
     ENSP00000453465   ENSP00000452833   ENSP00000354067  

    Human Recombinant Protein Products for CASC4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CASC4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CASC4
    GenScript Custom Purified and Recombinant Proteins Services for CASC4
    Novus Biologicals CASC4 Protein
    Novus Biologicals CASC4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CASC4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    CASC4 for ontologies           About GeneDecksing



    CASC4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CASC4
    GenScript Custom Superior Antibodies Services for CASC4
    Abcam antibodies for CASC4
    Cloud-Clone Corp. Antibodies for CASC4 
    ThermoFisher Antibodies for CASC4
    LSBio Antibodies in human, mouse, rat for CASC4 

    Assay Products for CASC4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CASC4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CASC4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CASC4 
    Cloud-Clone Corp. CLIAs for CASC4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR026139 GOLM1/CASC4
     IPR026141 CASC4

    Graphical View of Domain Structure for InterPro Entry Q6P4E1

    ProtoNet protein and cluster: Q6P4E1

    UniProtKB/Swiss-Prot: CASC4_HUMAN, Q6P4E1
    Similarity: Belongs to the GOLM1/CASC4 family


    CASC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 MGI phenotypic allele for Casc4 (no phenotypes)

    CASC4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CASC4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CASC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CASC4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CASC4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASC4
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CASC4 (see all 60):
    hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-1914* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidCASC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CASC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CASC4
    Sirion Biotech Customized adenovirus for overexpression of CASC4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CASC4 (see all 15)
    OriGene ORF clones in mouse, rat for CASC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CASC4 (NM_138423)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASC4
    Sirion Biotech Customized lentivirus for stable overexpression of CASC4 
                         Customized lentivirus expression plasmids for stable overexpression of CASC4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CASC4
    Search LifeMap BioReagents cell lines for CASC4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASC4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CASC4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CASC4 (Q6P4E13 ENSP000002999574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VDRP114733I2D: score=2 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CASC4

    Search CenterWatch for drugs/clinical trials and news about CASC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CASC4 gene (2 alternative transcripts): 
    NM_138423.3  NM_177974.2  

    Unigene Cluster for CASC4:

    Cancer susceptibility candidate 4
    Hs.512867  [show with all ESTs]
    Unigene Representative Sequence: NM_138423
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559222 ENST00000557945(uc010bdu.2) ENST00000299957(uc001ztp.3 uc001ztq.3)
    ENST00000429162 ENST00000345795 ENST00000558735 ENST00000559037 ENST00000558847
    ENST00000559550 ENST00000561305 ENST00000559151 ENST00000360824
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASC4
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CASC4 (see all 60):
    hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-1914* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidCASC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CASC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASC4
    Clone
    Products:
         
    OriGene clones in human, mouse for CASC4 (see all 15)
    OriGene ORF clones in mouse, rat for CASC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CASC4 (NM_138423)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASC4
    Sirion Biotech Customized lentivirus for stable overexpression of CASC4 
                         Customized lentivirus expression plasmids for stable overexpression of CASC4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CASC4
    OriGene qSTAR qPCR primer pairs in human, mouse for CASC4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CASC4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASC4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASC4

    Additional mRNA sequence: 

    AF103804.1 AK022565.1 AK095068.1 AK098265.1 AK291026.1 AK298564.1 AL832333.1 AL832840.1 
    AY358086.1 BC012124.1 BC041786.1 BC063480.1 

    14 DOTS entries:

    DT.100028397  DT.217119  DT.101982810  DT.100795219  DT.121030642  DT.121030663  DT.120783245  DT.100795220 
    DT.121030699  DT.120778864  DT.40270389  DT.91967557  DT.100795226  DT.95320643 

    24/277 AceView cDNA sequences (see all 277):

    AA281049 BG400307 BF971203 AI800354 AA651902 BM996495 BM981956 NM_177974 
    AY358086 BM546630 AA430755 BU186668 BU617831 AW513262 BU675483 BC012124 
    BG433320 BF034983 BG928640 BU742749 AK098265 AA630340 CA487682 AU124120 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CASC4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                                                                          
    SP2:                                                                    -     -     -         
    SP3:                          -                                                               
    SP4:                                                                                          


    ECgene alternative splicing isoforms for CASC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CASC4 expression in normal human tissues (normalized intensities)      CASC4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATTACCTG
    CASC4 Expression
    About this image


    CASC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See CASC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CASC4

    SOURCE GeneReport for Unigene cluster: Hs.512867
        SABiosciences Custom PCR Arrays for CASC4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CASC4
    OriGene qSTAR qPCR primer pairs in human, mouse for CASC4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CASC4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASC4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CASC4 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Casc41 , 5 cancer susceptibility candidate 41, 5 90.88(n)1
    90.55(a)1
      2 (60.43 cM)5
    3199961  NM_177054.51  NP_796028.21 
     1218669705 
    chicken
    (Gallus gallus)
    Aves CASC41 cancer susceptibility candidate 4 71.36(n)
    61.21(a)
      415575  NM_001030556.1  NP_001025727.1 
    lizard
    (Anolis carolinensis)
    Reptilia CASC46
    cancer susceptibility candidate 4
    63(a)
    1 ↔ 1
    GL343795.1(46137-60600)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ070790.12   -- 74.91(n)    BJ070790.1 
    zebrafish
    (Danio rerio)
    Actinopterygii casc41 cancer susceptibility candidate 4 53.87(n)
    43.28(a)
      555654  XM_678225.4  XP_683317.2 


    ENSEMBL Gene Tree for CASC4 (if available)
    TreeFam Gene Tree for CASC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CASC4 gene
    GOLM12  
    18/26 SIMAP similar genes for CASC4 using alignment to 6 protein entries:     CASC4_HUMAN (see all proteins) (see all similar genes):
    AVGR8    DUSP11    KIAA0101    LDLRAD3    SEPSECS    pp12301
    HC6    AAMDC    CATSPERD    ZNF66    COQ5    LOC100996577
    FP6778    LOC100996426    DYNC2LI1    PPP5D1    C4BPB    GOLM1

    CASC4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CASC4
    PGOHUM00000248312


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2000 SNPs in CASC4 are shown (see all 2000)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs803295261,2
    C,F--44578980(+) TTTTGT/CACAAT 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1470660131,2
    --44579048(+) CTTAAC/GTAGTT 2 -- us2k10--------
    rs1476829081,2
    --44579227(+) ACCGCA/GCCCGG 2 -- us2k10--------
    rs1927396651,2
    --44579313(+) CTTTAA/TAGTTA 2 -- us2k10--------
    rs1491391051,2
    C--44579510(+) TTCTAC/TGCTAC 2 -- us2k10--------
    rs786239021,2
    F--44579554(+) GAAGCC/ACAGAA 2 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1174155691,2
    C,F--44579742(+) CTCTAT/GGCACG 2 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1462738901,2
    C--44579787(+) TTTTG-/GTTTTT 2 -- us2k10--------
    rs1432346581,2
    --44579849(+) GCAGAC/TAGCAC 2 -- us2k10--------
    rs80373951,2
    C,F,A,H--44579854(+) CAGCAC/ATGGTG 2 -- us2k121Minor allele frequency- A:0.13NS EA NA WA 2664

    HapMap Linkage Disequilibrium report for CASC4 (44580909 - 44707959 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CASC4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904178CNV Loss21882294
    nsv904177CNV Loss21882294
    nsv904179CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CASC4
    DNA2.0 Custom Variant and Variant Library Synthesis for CASC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for CASC4:    About MalaCards
    ovarian cancer    soft tissue sarcoma    alcohol dependence    sarcoma
    alcoholism    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CASC4:
    Alcohol dependence

    CASC4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CASC4

    Export disorders for CASC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CASC4 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with CASC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    2. Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PubMed id 10497265)1, 3 Oh J.J.... Slamon D.J. (1999)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Automated yeast two-hybrid screening for nuclear rece ptor-interacting proteins. (PubMed id 15604093)1 Albers M....Koegl M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113201 HGNC: 24892 AceView: H63 Ensembl:ENSG00000166734 euGenes: HUgn113201
    ECgene: CASC4 H-InvDB: CASC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CASC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CASC4 gene:
    Search GeneIP for patents involving CASC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CASC4  
     OriGene qPCR primer pairs and template standards for CASC4   OriGene Protein Over-expression Lysate for CASC4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CASC4  
     OriGene qSTAR qPCR primer pairs in human, mouse for CASC4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CASC4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CASC4   OriGene Custom Protein Services for CASC4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CASC4
     QIAGEN SeqTarget long-range PCR primers for resequencing CASC4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASC4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASC4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASC4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASC4
     GenScript Custom Purified and Recombinant Proteins Services for CASC4 GenScript cDNA clones with any tag delivered in your preferred vector for CASC4
     GenScript Custom Assay Services for CASC4 GenScript Custom Superior Antibodies Services for CASC4
     GenScript Custom overexpressing Cell Line Services for CASC4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CASC4 promoter
     Search Chromatin IP Primers for CASC4
     RT2 qPCR Primer Assay in human, mouse, rat CASC4
     Search GNC Networks for CASC4
     SABiosciences Custom PCR Arrays for CASC4
     Search Tocris compounds for CASC4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CASC4 proteins
     CASC4 lysates
     Antibodies for CASC4
     See all of Abcam's Antibodies, Kits and Proteins for CASC4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CASC4
     Antibodies for CASC4
     ELISAs for CASC4
     CLIAs for CASC4
     Search LifeMap BioReagents cell lines for CASC4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASC4
     SwitchGear 3'UTR luciferase reporter plasmids for CASC4
     SwitchGear Promoter luciferase reporter plasmids for CASC4
     ThermoFisher Antibodies for CASC4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASC4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CASC4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CASC4
    Customized:
     lentivirus for stable overexpression of CASC4
     lentivirus expression plasmids for stable overexpression of CASC4
     adenovirus for overexpression of CASC4
     LSBio Antibodies in human, mouse, rat for CASC4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CASC4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4