CASC3 Gene
protein-coding GIFtS: 52
GCID: GC17P038296
|
|
cancer susceptibility candidate 3
| |
Aliases
for CASC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cancer Susceptibility Candidate 31 2 | | MLN 512 3 | | MLN511 2 3 5 | | Barentsz1 | | BTZ1 2 | | Metastatic Lymph Node 512 | | Cancer Susceptibility Candidate Gene 3 Protein2 3 | | Protein CASC32 | | Metastatic Lymph Node Gene 51 Protein2 3 | | Btz3 | | Protein Barentsz2 3 | | |
Export aliases for CASC3 gene to outside databasesPrevious GC identifers: GC00U914332 GC17P038651 GC17P035550 GC17P034089 |
Summaries
for CASC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CASC3:
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited onspliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein bindsRNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles intothe nucleus where it localizes to nuclear speckles. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CASC3_HUMAN, O15234Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction onmRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear andcytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequentmRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNAmetabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influencesdownstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization,translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities ofEIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoringcell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons(By similarity). May play a role in mRNA transport (By similarity). Binds spliced mRNA in sequence-independent manner,20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer
Gene Wiki entry for CASC3
|
Genomic Views
for CASC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CASC3 gene promoter:
Pax-2 Olf-1 Lmo2 Pax-2a POU6F1 (c2) C/EBPalpha GATA-1 GATA-2 HNF-4alpha1 HOXA5
Other transcription factors
Search SABiosciences Chromatin IP Primers for CASC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q21.1 HGNC cytogenetic band: 17q21.1CASC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P038296: view genomic region
(about GC identifiers)
Start:
|
38,296,507 bp from pter |
End:
|
38,328,431 bp from pter |
Size:
|
31,925 bases |
Orientation:
|
plus strand |
|
Proteins
for CASC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CASC3_HUMAN, O15234 (See
protein sequence)Recommended Name: Protein CASC3 Size: 703 amino acids; 76278 Da
Subunit: Forms homooligomers (By similarity). Interacts with STAU in an RNA-dependent manner (By similarity). Part ofthe EJC core complex that contains CASC3, EIF4A3, MAGOH and RBM8A. Found in a mRNA splicing-dependent exon junctioncomplex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and ALYREF/THOC4. Interactswith EIF4A3, MAGOH, NXF1 and RBM8A
Subcellular location: Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Note=Predominantly found in theperinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Travelsto the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and thestress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclearspeckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclearspeckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors,in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress
6 PDB 3D structures from  and Proteopedia  for CASC3:2HYI (3D)
2J0Q (3D)
2J0S (3D)
2J0U (3D)
2XB2 (3D)
3EX7 (3D)
Secondary accessions: A8K8R0Explore the universe of human proteins at neXtProt for CASC3: NX_O15234
Post-translational modifications:
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed byubiquitination1
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15234
CASC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_031385.2
ENSEMBL proteins: ENSP00000264645 ENSP00000467654 ENSP00000462713 ENSP00000464626 Reactome Protein details: O15234
Human Recombinant Protein Products for CASC3:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
CASC3 for ontologies About GeneDecksing
CASC3 Antibody Products:
Assay Products for CASC3: |
Protein
Domains /
Families
for CASC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CASC3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O15234ProtoNet protein and cluster: O15234 UniProtKB/Swiss-Prot: CASC3_HUMAN, O15234Domain: The coiled coil domain may be involved in oligomerizationSimilarity: Belongs to the CASC3 family |
Function
for CASC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CASC3_HUMAN, O15234Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction onmRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear andcytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequentmRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNAmetabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influencesdownstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization,translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities ofEIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoringcell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons(By similarity). May play a role in mRNA transport (By similarity). Binds spliced mRNA in sequence-independent manner,20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
CASC3 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASC3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASC3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CASC3 (NM_007359) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CASC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASC3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASC3 |
|
Pathways & Interactions
for CASC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Metabolism of mRNA | | | 3 | mRNA surveillance pathway | | | 4 | RNA transport | | | 5 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for CASC3 (see all 7)
2 
Kegg Pathways (Kegg details for CASC3):
CASC3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CASC3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/82 Interacting proteins for CASC3 (O152341, 3 ENSP000002646454) via UniProtKB, MINT, STRING, and/or I2D (see all 82)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0006397 | mRNA processing |
IEA | -- | | GO:0006417 | regulation of translation |
IEA | -- | | GO:0006950 | response to stress |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
CASC3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CASC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CASC3
Search CenterWatch for drugs/clinical trials and news about CASC3
|
Transcripts
for CASC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CASC3 gene: NM_007359.4 Unigene Cluster for CASC3: Cancer susceptibility candidate 3 Hs.743287 [show with all ESTs]Unigene Representative Sequence: NM_00735910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000418132(uc010cws.1) ENST00000264645(uc010cwt.1 uc002hue.3)
ENST00000581849 ENST00000583649 ENST00000584997 ENST00000474190 ENST00000577605
ENST00000579238 ENST00000583902 ENST00000394114
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASC3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASC3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CASC3 (NM_007359) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CASC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASC3 |
Additional cDNA sequence: AK292425.1 AK296682.1 AK310635.1 BC030008.1 BC044656.1 BC050526.1 X80199.2 13 DOTS entries: DT.100790275 DT.92459270 DT.100790269 DT.100790273 DT.100790277 DT.99933836 DT.95227579 DT.120908638 DT.100743421 DT.102828187 DT.120908649 DT.120908659 DT.91953170 24/442 AceView cDNA sequences (see all 442): Z43520 AI129886 BU737993 BU542218 BU186884 AI434502 AI609588 BQ549662 CA391940 AU128000 BG566470 BE350517 BM505130 BP357598 BQ269548 AU124725 BM479192 BC044656 AW015882 AI743300 AA936531 BQ053024 BQ286184 AI184828
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CASC3 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 13b |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for CASC3
|
Expression
for CASC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CASC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGGTGGTG
About this image
See CASC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CASC3
SOURCE GeneReport for Unigene cluster: Hs.743287
UniProtKB/Swiss-Prot: CASC3_HUMAN, O15234Tissue specificity: Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers
SABiosciences Custom PCR Arrays for CASC3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CASC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASC3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASC3 |
Orthologs
for CASC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CASC3 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for CASC3 (if available)
TreeFam Gene Tree for CASC3 (if available) |
Paralogs
for CASC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CASC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CASC3 (38296507 - 38328431 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CASC3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASC3 |
|
Disorders
/ Diseases
for CASC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CASC3 for disorders About GeneDecksing
OMIM gene information: 606504
OMIM disorders: --
6  diseases for CASC3: About MalaCardsgastric cancer breast carcinoma breast cancer tuberculosis
carcinoma neuronitis
Export disorders for CASC3 gene to outside databases
|
Publications
for CASC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CASC3 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with CASC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)1, 2, 3 Tomasetto C.L.... Rio M.-C. (1995)
- Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. (PubMed id 15166247)1, 2, 9 Degot S....Tomasetto C. (2004)
- The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly. (PubMed id 17652158)1, 2, 9 Baguet A.... Tomasetto C. (2007)
- The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. (PubMed id 16923391)1, 2, 9 Bono F.... Conti E. (2006)
- Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines. (PubMed id 18332872)1, 3 Arriola E....Reis-Filho J.S. (2008)
- Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. (PubMed id 16931718)1, 2 Andersen C.B....Andersen G.R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. (PubMed id 16314458)1, 2 Tange T.O.... Moore M.J. (2005)
- The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. (PubMed id 16170325)1, 2 Ballut L....Le Hir H. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
|
External Searches for CASC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CASC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CASC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CASC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CASC3 gene:
Search GeneIP for patents involving CASC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CASC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CASC3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASC3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASC3 | | | OriGene Protein Over-expression Lysate for CASC3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CASC3 | | OriGene 3'-UTR Clone for CASC3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASC3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASC3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CASC3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CASC3 | | OriGene Custom Protein Services for CASC3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CASC3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASC3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASC3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASC3 |
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| | | | Search Tocris compounds for CASC3 |
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 | | | CASC3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASC3 |
|  |  |  |  | | | | ThermoFisher Antibodies for CASC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASC3 |
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