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Aliases for CASC2 Gene

Subcategory (RNA class) for CASC2 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for CASC2 Gene

  • Cancer Susceptibility Candidate 2 (Non-Protein Coding) 2 3 5
  • C10orf5 3 4
  • Cancer Susceptibility Candidate Gene 2 Protein Isoforms 1/2 4
  • Cancer Susceptibility Candidate Gene 2 Protein, Isoform 3 4
  • Chromosome 10 Open Reading Frame 5 2
  • Cancer Susceptibility Candidate 2 2

External Ids for CASC2 Gene

Previous HGNC Symbols for CASC2 Gene

  • C10orf5

Previous GeneCards Identifiers for CASC2 Gene

  • GC10P119470
  • GC10P119471
  • GC10P119796
  • GC10P113434

Summaries for CASC2 Gene

GeneCards Summary for CASC2 Gene

CASC2 (Cancer Susceptibility Candidate 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

UniProtKB/Swiss-Prot for CASC2 Gene

  • May act as a potential tumor suppressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC2 Gene

Genomics for CASC2 Gene

Regulatory Elements for CASC2 Gene

Enhancers for CASC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F118045 1.1 ENCODE 5.6 +0.2 214 2.7 ATF1 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 ELK1 CASC2 RAB11FIP2
GH10F118017 0.4 ENCODE 11.4 -28.4 -28403 0.8 TEAD4 RAB11FIP2 CASC2 ENSG00000231104
GH10F118034 0.7 Ensembl ENCODE 5 -10.3 -10342 2.1 MAFK MYC CASC2 ENSG00000231104
GH10F118168 0.2 ENCODE 8.6 +121.2 121220 0.3 CASC2 GC10P118108 LOC101927760
GH10F118031 0.2 ENCODE 7.2 -13.8 -13802 2.2 CASC2 ENSG00000231104
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CASC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CASC2 Gene

118,046,279 bp from pter
118,210,153 bp from pter
163,875 bases
Plus strand

Genomic View for CASC2 Gene

Genes around CASC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC2 Gene

Proteins for CASC2 Gene

  • Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein CASC2, isoform 3
    Protein Accession:
    Secondary Accessions:
    • D3DRC5

    Protein attributes for CASC2 Gene

    102 amino acids
    Molecular mass:
    11902 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC2 Gene

  • Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein CASC2, isoforms 1/2
    Protein Accession:
    Secondary Accessions:
    • Q2M1K1
    • Q8IUI3

    Protein attributes for CASC2 Gene

    76 amino acids
    Molecular mass:
    8607 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC2 Gene


neXtProt entry for CASC2 Gene

Post-translational modifications for CASC2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CASC2 Gene

Domains & Families for CASC2 Gene

Protein Domains for CASC2 Gene


Suggested Antigen Peptide Sequences for CASC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CASC2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CASC2 Gene

Function for CASC2 Gene

Molecular function for CASC2 Gene

UniProtKB/Swiss-Prot Function:
May act as a potential tumor suppressor.
UniProtKB/Swiss-Prot Induction:
Down-regulated in endometrial and colorectal tumor samples.

Phenotypes for CASC2 Gene

genes like me logo Genes that share phenotypes with CASC2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CASC2 Gene

Localization for CASC2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CASC2 Gene

Pathways & Interactions for CASC2 Gene

SuperPathways for CASC2 Gene

No Data Available

Interacting Proteins for CASC2 Gene

Gene Ontology (GO) - Biological Process for CASC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CASC2 Gene

Transcripts for CASC2 Gene

Unigene Clusters for CASC2 Gene

Cancer susceptibility candidate 2 (non-protein coding):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CASC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASC2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP3: -
SP4: - -
SP5: - - - -

Relevant External Links for CASC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CASC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CASC2 Gene

mRNA differential expression in normal tissues according to GTEx for CASC2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of CASC2 Gene:


SOURCE GeneReport for Unigene cluster for CASC2 Gene:


mRNA Expression by UniProt/SwissProt for CASC2 Gene:

Tissue specificity: Expressed in normal and neoplastic endometrial tissues.
genes like me logo Genes that share expression patterns with CASC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CASC2 Gene

Orthologs for CASC2 Gene

Evolution for CASC2 Gene

Gene Tree for CASC2 (if available)
Gene Tree for CASC2 (if available)

No data available for Orthologs for CASC2 Gene

Paralogs for CASC2 Gene

No data available for Paralogs for CASC2 Gene

Variants for CASC2 Gene

Sequence variations from dbSNP and Humsavar for CASC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_039469 Some patients with endometrial cancer
rs1029785 -- 118,123,448(+) tacca(C/T)gtatg intron-variant
rs1029786 -- 118,187,874(+) atatt(A/G)tctat intron-variant
rs1029787 -- 118,187,974(+) tatag(A/C)aaaag intron-variant
rs10444115 -- 118,205,346(+) TTTCC(A/G)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASC2 Gene

Variant ID Type Subtype PubMed ID
nsv958495 CNV insertion 24416366
nsv951860 CNV duplication 24416366
nsv819998 CNV loss 19587683
nsv7567 CNV insertion 18451855
nsv7566 CNV deletion 18451855
nsv1120230 CNV tandem duplication 24896259
nsv1113339 CNV deletion 24896259
nsv1047815 CNV gain 25217958
esv2741517 CNV deletion 23290073
esv2741506 CNV deletion 23290073
esv2741495 CNV deletion 23290073
esv2741484 CNV deletion 23290073
esv2580643 CNV deletion 19546169
esv1573329 CNV insertion 17803354
esv1538733 CNV insertion 17803354
esv1289381 CNV insertion 17803354
esv1096716 CNV insertion 17803354

Relevant External Links for CASC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CASC2 Gene

Disorders for CASC2 Gene

Relevant External Links for CASC2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CASC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASC2 Gene

Publications for CASC2 Gene

  1. Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer. (PMID: 15024726) Baldinu P. … Palmieri G. (Hum. Mutat. 2004) 3 4 22 64
  2. CASC2a gene is down-regulated in endometrial cancer. (PMID: 17352238) Baldinu P. … Palmieri G. (Anticancer Res. 2007) 4 22 64
  3. Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21. (PMID: 25446261) Wang P. … Xue Y.X. (Cell. Signal. 2015) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CASC2 Gene

Sources for CASC2 Gene

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