Aliases for CASC2 Gene
Subcategory (RNA class) for CASC2 Gene
non-coding RNA
Quality Score for this RNA gene is
3
Aliases for CASC2 Gene
- Cancer Susceptibility 2 (Non-Protein Coding) 2 3 5
- Cancer Susceptibility Candidate 2 (Non-Protein Coding) 2 3
- C10orf5 3 4
- Cancer Susceptibility Candidate Gene 2 Protein Isoforms 1/2 4
- Cancer Susceptibility Candidate Gene 2 Protein, Isoform 3 4
- Chromosome 10 Open Reading Frame 5 2
- Cancer Susceptibility Candidate 2 2
External Ids for CASC2 Gene
Previous HGNC Symbols for CASC2 Gene
- C10orf5
Previous GeneCards Identifiers for CASC2 Gene
- GC10P119470
- GC10P119471
- GC10P119796
- GC10P113434
Summaries for CASC2 Gene
GeneCards Summary for CASC2 Gene
CASC2 (Cancer Susceptibility 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CASC2 include Endometrial Cancer.
UniProtKB/Swiss-Prot for CASC2 Gene
-
May act as a potential tumor suppressor.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC2 Gene
Genomics for CASC2 Gene
Regulatory Elements for CASC2 Gene
Enhancers for CASC2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH10G118045 | 1.1 | ENCODE | 5.6 | +0.2 | 214 | 2.7 | HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF263 | CASC2 RAB11FIP2 |
| GH10G118017 | 0.4 | ENCODE | 11.4 | -28.4 | -28403 | 0.8 | TEAD4 | RAB11FIP2 CASC2 ENSG00000231104 |
| GH10G118034 | 0.7 | Ensembl ENCODE | 5.1 | -10.6 | -10609 | 1.6 | MYC PRDM4 | CASC2 ENSG00000231104 |
| GH10G118168 | 0.4 | ENCODE | 8.6 | +121.2 | 121220 | 0.3 | CEBPG | CASC2 GC10P118108 LOC101927760 |
| GH10G118031 | 0.4 | ENCODE | 7.3 | -13.8 | -13802 | 2.2 | EP300 | CASC2 ENSG00000231104 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CASC2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CASC2 gene promoter:
Regulatory Element Products
Genomic Location for CASC2 Gene
- Chromosome:
- 10
- Start:
- 118,046,279 bp from pter
- End:
- 118,210,153 bp from pter
- Size:
- 163,875 bases
- Orientation:
- Plus strand
Genomic View for CASC2 Gene
Genes around CASC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.11 by Ensembl
- 10q26.11 by Entrez Gene
- 10q26.11 by HGNC
CASC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CASC2 Gene
Proteins for CASC2 Gene
-
Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6XLA1-CSC2A_HUMAN
- Recommended name:
- Protein CASC2, isoform 3
- Protein Accession:
- Q6XLA1
- D3DRC5
Protein attributes for CASC2 Gene
- Size:
- 102 amino acids
- Molecular mass:
- 11902 Da
- Quaternary structure:
- No Data Available
-
Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IU53-CASC2_HUMAN
- Recommended name:
- Protein CASC2, isoforms 1/2
- Protein Accession:
- Q8IU53
- Q2M1K1
- Q8IUI3
Protein attributes for CASC2 Gene
- Size:
- 76 amino acids
- Molecular mass:
- 8607 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CASC2 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for CASC2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CASC2
- Origene Custom Protein Services for CASC2
- Search GeneTex for Proteins for CASC2
Assay Products
No data available for DME Specific Peptides for CASC2 Gene
Domains & Families for CASC2 Gene
Protein Domains for CASC2 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for CASC2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CASC2 Gene
Function for CASC2 Gene
Molecular function for CASC2 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a potential tumor suppressor.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in endometrial and colorectal tumor samples.
Phenotypes for CASC2 Gene
- GenomeRNAi human phenotypes for CASC2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CASC2
-
- Search ViGene Biosciences for CASC2
CRISPR Products
- Browse CRISPR knockouts for CASC2
miRNA Products
- Search ViGene Biosciences for CASC2
Inhibitory RNA Products
- Origene RNAi and shRNA products in human, mouse, rat for CASC2
- Browse OriGene Inhibitory RNA Products For CASC2
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Clone Products
- GenScript: Custom all cDNA clones Services for CASC2
- Addgene plasmids for CASC2
- VectorBuilder custom plasmid, inducible vectors for CASC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CASC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for CASC2
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CASC2 Gene
Localization for CASC2 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CASC2 Gene
Transcripts for CASC2 Gene
mRNA/cDNA for CASC2 Gene
- (2) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (42) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CASC2 Gene
CRISPR Products
- Browse CRISPR knockouts for CASC2
miRNA Products
- Search ViGene Biosciences for CASC2
Inhibitory RNA Products
- Origene RNAi and shRNA products in human, mouse, rat for CASC2
- Browse OriGene Inhibitory RNA Products For CASC2
- Search ViGene Biosciences for CASC2
Clone Products
- GenScript: Custom all cDNA clones Services for CASC2
- Addgene plasmids for CASC2
- VectorBuilder custom plasmid, inducible vectors for CASC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CASC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||
| SP5: | - | - | - | - |
Expression for CASC2 Gene
mRNA differential expression in normal tissues according to GTEx for CASC2 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).
NURSA nuclear receptor signaling pathways regulating expression of CASC2 Gene:
CASC2SOURCE GeneReport for Unigene cluster for CASC2 Gene:
Hs.89387mRNA Expression by UniProt/SwissProt for CASC2 Gene:
Q6XLA1-CSC2A_HUMAN
Tissue specificity:
Expressed in normal and neoplastic endometrial tissues.
Primer Products
-
OriGene qPCR primer pairs for CASC2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASC2 Gene
Orthologs for CASC2 Gene
No data available for Orthologs for CASC2 Gene
Paralogs for CASC2 Gene
No data available for Paralogs for CASC2 Gene
Variants for CASC2 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_039469 | Some patients with endometrial cancer | ||||
| rs1000010883 | -- | 118,120,568(+) | AGAGC(G/T)TCTTT | intron-variant | |
| rs1000011013 | -- | 118,058,071(+) | GATAA(C/T)ATGAA | intron-variant | |
| rs1000029385 | -- | 118,102,357(+) | ATTTG(G/T)GACTG | intron-variant | |
| rs1000087634 | -- | 118,047,804(+) | TCTTA(A/C)CTTCC | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1096716 | CNV | insertion | 17803354 |
| esv1289381 | CNV | insertion | 17803354 |
| esv1538733 | CNV | insertion | 17803354 |
| esv1573329 | CNV | insertion | 17803354 |
| esv2580643 | CNV | deletion | 19546169 |
| esv2741484 | CNV | deletion | 23290073 |
| esv2741495 | CNV | deletion | 23290073 |
| esv2741506 | CNV | deletion | 23290073 |
| esv2741517 | CNV | deletion | 23290073 |
| nsv1047815 | CNV | gain | 25217958 |
| nsv1113339 | CNV | deletion | 24896259 |
| nsv1120230 | CNV | tandem duplication | 24896259 |
| nsv7566 | CNV | deletion | 18451855 |
| nsv7567 | CNV | insertion | 18451855 |
| nsv819998 | CNV | loss | 19587683 |
| nsv951860 | CNV | duplication | 24416366 |
| nsv958495 | CNV | insertion | 24416366 |
Relevant External Links for CASC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CASC2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CASC2 Gene
Disorders for CASC2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| endometrial cancer |
|
|
Search CASC2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CASC2
No data available for UniProtKB/Swiss-Prot and Genatlas for CASC2 Gene
Publications for CASC2 Gene
- Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer. (PMID: 15024726) Baldinu P. … Palmieri G. (Hum. Mutat. 2004) 3 4 22 64
- CASC2a gene is down-regulated in endometrial cancer. (PMID: 17352238) Baldinu P. … Palmieri G. (Anticancer Res. 2007) 4 22 64
- Long non-coding RNA CASC2 in human cancer. (PMID: 28259293) Palmieri G. … Cossu A. (Crit. Rev. Oncol. Hematol. 2017) 3 64
- Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer. (PMID: 26790438) He X. … Guo R. (Tumour Biol. 2016) 3 64
- Downregulation of lncRNA CASC2 by microRNA-21 increases the proliferation and migration of renal cell carcinoma cells. (PMID: 27222255) Cao Y. … He X. (Mol Med Rep 2016) 3 64
Products for CASC2 Gene
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- Custom Antibody Services
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- Novus Biologicals
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- Addgene plasmids for CASC2
- Search GeneTex for Antibodies for CASC2
- Search GeneTex for Proteins for CASC2
- Search ViGene Biosciences for CASC2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CASC2
- VectorBuilder custom plasmid, inducible vectors for CASC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CASC2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CASC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
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- (122) diseasecard
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer