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Aliases for CASC2 Gene

Subcategory (RNA class) for CASC2 Gene

antisense

Quality Score for this RNA gene is

3

Aliases for CASC2 Gene

  • Cancer Susceptibility Candidate 2 (Non-Protein Coding) 2 3
  • C10orf5 3 4
  • Cancer Susceptibility Candidate Gene 2 Protein Isoforms 1/2 4
  • Cancer Susceptibility Candidate Gene 2 Protein, Isoform 3 4
  • Chromosome 10 Open Reading Frame 5 2
  • Cancer Susceptibility Candidate 2 2

External Ids for CASC2 Gene

ORGUL Members for CASC2 Gene

Previous HGNC Symbols for CASC2 Gene

  • C10orf5

Previous GeneCards Identifiers for CASC2 Gene

  • GC10P119470
  • GC10P119471
  • GC10P119796
  • GC10P113434

Summaries for CASC2 Gene

GeneCards Summary for CASC2 Gene

CASC2 (Cancer Susceptibility Candidate 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the antisense RNA class.

UniProtKB/Swiss-Prot for CASC2 Gene

  • May act as a potential tumor suppressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC2 Gene

Genomics for CASC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CASC2 Gene

Start:
118,046,279 bp from pter
End:
118,210,153 bp from pter
Size:
163,875 bases
Orientation:
Plus strand

Genomic View for CASC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC2 Gene

Proteins for CASC2 Gene

  • Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XLA1-CSC2A_HUMAN
    Recommended name:
    Protein CASC2, isoform 3
    Protein Accession:
    Q6XLA1
    Secondary Accessions:
    • D3DRC5

    Protein attributes for CASC2 Gene

    Size:
    102 amino acids
    Molecular mass:
    11902 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC2 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU53-CASC2_HUMAN
    Recommended name:
    Protein CASC2, isoforms 1/2
    Protein Accession:
    Q8IU53
    Secondary Accessions:
    • Q2M1K1
    • Q8IUI3

    Protein attributes for CASC2 Gene

    Size:
    76 amino acids
    Molecular mass:
    8607 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASC2 Gene

Proteomics data for CASC2 Gene at MOPED

Post-translational modifications for CASC2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CASC2 Gene

Domains for CASC2 Gene

Gene Families for CASC2 Gene

HGNC:
  • LNCRNA :Long non-coding RNAs

Protein Domains for CASC2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CASC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CASC2: view

No data available for UniProtKB/Swiss-Prot for CASC2 Gene

Function for CASC2 Gene

Molecular function for CASC2 Gene

UniProtKB/Swiss-Prot Function: May act as a potential tumor suppressor.
UniProtKB/Swiss-Prot Induction: Down-regulated in endometrial and colorectal tumor samples.

Phenotypes for CASC2 Gene

genes like me logo Genes that share phenotypes with CASC2: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CASC2 Gene

Localization for CASC2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CASC2 Gene

Pathways for CASC2 Gene

SuperPathways for CASC2 Gene

No Data Available

Interacting Proteins for CASC2 Gene

Gene Ontology (GO) - Biological Process for CASC2 Gene

None

No data available for Pathways by source for CASC2 Gene

Transcripts for CASC2 Gene

Unigene Clusters for CASC2 Gene

Cancer susceptibility candidate 2 (non-protein coding):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CASC2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASC2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2:
SP3: -
SP4: - -
SP5: - - - -

Relevant External Links for CASC2 Gene

GeneLoc Exon Structure for
CASC2
ECgene alternative splicing isoforms for
CASC2

Expression for CASC2 Gene

mRNA expression in normal human tissues for CASC2 Gene

mRNA differential expression in normal tissues according to GTEx for CASC2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.6).

SOURCE GeneReport for Unigene cluster for CASC2 Gene Hs.89387

mRNA Expression by UniProt/SwissProt for CASC2 Gene

Q6XLA1-CSC2A_HUMAN
Tissue specificity: Expressed in normal and neoplastic endometrial tissues.
genes like me logo Genes that share expressions with CASC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CASC2 Gene

Orthologs for CASC2 Gene

Evolution for CASC2 Gene

ENSEMBL:
Gene Tree for CASC2 (if available)
TreeFam:
Gene Tree for CASC2 (if available)

No data available for Orthologs for CASC2 Gene

Paralogs for CASC2 Gene

No data available for Paralogs for CASC2 Gene

Variants for CASC2 Gene

Sequence variations from dbSNP and Humsavar for CASC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1369 -- 118,207,731(+) AAATT(G/T)GGTTC nc-transcript-variant
rs703422 -- 118,068,666(+) AATCC(A/G)TACAA intron-variant
rs703423 -- 118,175,353(+) TGCGT(A/G)AGTTT intron-variant
rs703424 -- 118,190,236(+) GGAGG(A/C)AGCAG intron-variant
rs703425 -- 118,193,222(-) GTGAA(C/T)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASC2 Gene

Variant ID Type Subtype PubMed ID
nsv7566 CNV Loss 18451855
nsv7567 CNV Insertion 18451855
nsv819998 CNV Loss 19587683
esv2580643 CNV Deletion 19546169
esv2741484 CNV Deletion 23290073
esv2741495 CNV Deletion 23290073
esv2741506 CNV Deletion 23290073
esv1289381 CNV Insertion 17803354
esv1573329 CNV Insertion 17803354
esv1538733 CNV Insertion 17803354
esv1096716 CNV Insertion 17803354
esv2741517 CNV Deletion 23290073

Relevant External Links for CASC2 Gene

HapMap Linkage Disequilibrium report
CASC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASC2 Gene

Disorders for CASC2 Gene

Relevant External Links for CASC2

Genetic Association Database (GAD)
CASC2
genes like me logo Genes that share disorders with CASC2: view

No data available for UniProtKB/Swiss-Prot for CASC2 Gene

Publications for CASC2 Gene

  1. Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer. (PMID: 15024726) Baldinu P. … Palmieri G. (Hum. Mutat. 2004) 3 4 23
  2. CASC2a gene is down-regulated in endometrial cancer. (PMID: 17352238) Baldinu P. … Palmieri G. (Anticancer Res. 2007) 4 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21. (PMID: 25446261) Wang P. … Xue Y.X. (Cell. Signal. 2015) 3

Products for CASC2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CASC2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CASC2
    • Block miRNA regulation of CASC2 using miScript Target Protectors

    Sources for CASC2 Gene

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