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Aliases for CASC15 Gene

Subcategory (RNA class) for CASC15 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for CASC15 Gene

  • Cancer Susceptibility Candidate 15 (Non-Protein Coding) 2 3 5
  • Long Intergenic Non-Protein Coding RNA 340 2 3
  • LINC00340 3

External Ids for CASC15 Gene

Previous HGNC Symbols for CASC15 Gene

  • LINC00340

Summaries for CASC15 Gene

GeneCards Summary for CASC15 Gene

CASC15 (Cancer Susceptibility Candidate 15 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CASC15 include Astigmatism and Refractive Error.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC15 Gene

Genomics for CASC15 Gene

Regulatory Elements for CASC15 Gene

Enhancers for CASC15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F021593 1.1 ENCODE 13.4 -68.2 -68208 7.0 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 BOLA2P3 ENSG00000233848 CASC15 SOX4 GC06P021597 ENSG00000283480
GH06F022042 0.7 Ensembl ENCODE 20.8 +378.5 378456 1.5 SMARCA4 IKZF1 ZNF24 CASC15 RN7SKP240 GC06P021990
GH06F022044 0.6 ENCODE 18 +380.7 380679 1.0 MTA2 IKZF1 NBN TRIM22 MLLT1 BMI1 TBX21 CASC15 RN7SKP240 GC06P021990
GH06F021925 1.1 Ensembl ENCODE 4.7 +261.8 261840 2.5 KLF1 CBX3 ATF1 ETV1 JUN ZNF175 CEBPG ZNF335 CBX5 RBAK CASC15 GC06P021926 GC06M021864
GH06F021873 0.8 Ensembl ENCODE 4.6 +209.1 209084 1.0 JUND FOS NFE2 NFE2L2 CASC15 GC06M021864 GC06P021860
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CASC15 on UCSC Golden Path with GeneCards custom track

Promoters for CASC15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001213286 1429 4400 PKNOX1 ZNF76 ZNF335 SCRT2 EGR2 ZNF263 ZBTB11 REST ZEB2 GLIS1

Genomic Location for CASC15 Gene

Chromosome:
6
Start:
21,664,772 bp from pter
End:
22,368,328 bp from pter
Size:
703,557 bases
Orientation:
Plus strand

Genomic View for CASC15 Gene

Genes around CASC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC15 Gene

Proteins for CASC15 Gene

Post-translational modifications for CASC15 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CASC15 Gene

Domains & Families for CASC15 Gene

Gene Families for CASC15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CASC15: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CASC15 Gene

Function for CASC15 Gene

Phenotypes for CASC15 Gene

GenomeRNAi human phenotypes for CASC15:
genes like me logo Genes that share phenotypes with CASC15: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CASC15 Gene

Localization for CASC15 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CASC15 Gene

Pathways & Interactions for CASC15 Gene

SuperPathways for CASC15 Gene

No Data Available

Interacting Proteins for CASC15 Gene

Gene Ontology (GO) - Biological Process for CASC15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CASC15 Gene

Transcripts for CASC15 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CASC15 Gene

No ASD Table

Relevant External Links for CASC15 Gene

GeneLoc Exon Structure for
CASC15
ECgene alternative splicing isoforms for
CASC15

Expression for CASC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CASC15 Gene

NURSA nuclear receptor signaling pathways regulating expression of CASC15 Gene:

CASC15
genes like me logo Genes that share expression patterns with CASC15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CASC15 Gene

Orthologs for CASC15 Gene

Evolution for CASC15 Gene

ENSEMBL:
Gene Tree for CASC15 (if available)
TreeFam:
Gene Tree for CASC15 (if available)

No data available for Orthologs for CASC15 Gene

Paralogs for CASC15 Gene

No data available for Paralogs for CASC15 Gene

Variants for CASC15 Gene

Sequence variations from dbSNP and Humsavar for CASC15 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10046106 -- 21,784,569(+) tctct(A/C)ccaaa intron-variant
rs1012013 -- 21,977,429(-) TTTTT(C/T)CTTGG intron-variant
rs10223697 -- 21,817,145(+) ctccc(A/G)agtgg intron-variant
rs1022466 -- 22,088,025(-) CTACA(A/C)TGAAG intron-variant
rs1023056 -- 21,988,523(+) GCATA(G/T)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASC15 Gene

Variant ID Type Subtype PubMed ID
nsv830602 CNV gain 17160897
nsv823450 CNV loss 20364138
nsv823445 CNV loss 20364138
nsv823444 CNV loss 20364138
nsv819249 CNV loss 19587683
nsv818402 CNV loss 17921354
nsv601104 CNV loss 21841781
nsv601097 CNV loss 21841781
nsv525875 CNV loss 19592680
nsv5224 CNV insertion 18451855
nsv5223 CNV deletion 18451855
nsv516909 CNV loss 19592680
nsv516009 CNV loss 19592680
nsv511855 CNV loss 21212237
nsv510019 OTHER sequence alteration 20534489
nsv499608 CNV loss 21111241
nsv475311 CNV novel sequence insertion 20440878
nsv437478 CNV loss 16327808
nsv349883 CNV deletion 16902084
nsv349514 CNV deletion 16902084
nsv348739 CNV deletion 16902084
nsv348606 CNV deletion 16902084
nsv1161343 CNV deletion 26073780
nsv1129268 CNV deletion 24896259
nsv1124044 CNV deletion 24896259
nsv1073194 CNV deletion 25765185
nsv1025837 CNV loss 25217958
esv3890798 CNV loss 25118596
esv3890797 CNV loss 25118596
esv3608331 CNV gain 21293372
esv3608330 CNV loss 21293372
esv3608328 CNV loss 21293372
esv3608325 CNV loss 21293372
esv3608324 CNV loss 21293372
esv3608323 CNV loss 21293372
esv3608320 CNV loss 21293372
esv3608317 CNV gain 21293372
esv3608315 CNV loss 21293372
esv3608314 CNV loss 21293372
esv3608313 CNV loss 21293372
esv3608312 CNV loss 21293372
esv3576104 CNV gain 25503493
esv3570804 CNV loss 25503493
esv3570802 CNV loss 25503493
esv3570800 CNV loss 25503493
esv3570799 CNV loss 25503493
esv3570797 CNV loss 25503493
esv3570795 CNV loss 25503493
esv3567396 CNV deletion 23714750
esv3567393 CNV deletion 23714750
esv3451137 CNV insertion 20981092
esv3431161 CNV insertion 20981092
esv3419255 CNV insertion 20981092
esv3376599 CNV insertion 20981092
esv3339910 CNV insertion 20981092
esv3336232 CNV insertion 20981092
esv3322146 CNV insertion 20981092
esv3308781 CNV mobile element insertion 20981092
esv3303671 CNV mobile element insertion 20981092
esv2763540 CNV loss 21179565
esv2731680 CNV deletion 23290073
esv2731679 CNV deletion 23290073
esv2731678 CNV deletion 23290073
esv2731677 CNV deletion 23290073
esv27155 CNV loss 19812545
esv2678811 CNV deletion 23128226
esv2678070 CNV deletion 23128226
esv2675345 CNV deletion 23128226
esv2670770 CNV deletion 23128226
esv2667198 CNV deletion 23128226
esv2660578 CNV deletion 23128226
esv2659390 CNV deletion 23128226
esv2621401 CNV deletion 19546169
esv25369 CNV loss 19812545
esv24725 CNV loss 19812545
dgv374n21 CNV loss 19592680
dgv3285n106 CNV deletion 24896259
dgv1718e212 CNV loss 25503493
dgv1717e212 CNV loss 25503493
dgv1170e214 CNV loss 21293372
dgv1078e199 CNV deletion 23128226
dgv10324n54 CNV loss 21841781
dgv10323n54 CNV loss 21841781
dgv10322n54 CNV loss 21841781
dgv10321n54 CNV loss 21841781
dgv10320n54 CNV loss 21841781
dgv10319n54 CNV loss 21841781
dgv1002n67 CNV loss 20364138

Relevant External Links for CASC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CASC15 Gene

Disorders for CASC15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CASC15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
astigmatism
refractive error
  • refractive errors
neuroblastoma, susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CASC15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASC15
genes like me logo Genes that share disorders with CASC15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASC15 Gene

Publications for CASC15 Gene

  1. The CASC15 Long Intergenic Noncoding RNA Locus Is Involved in Melanoma Progression and Phenotype Switching. (PMID: 26016895) Lessard L. … Hoon D.S. (J. Invest. Dermatol. 2015) 2 3 64
  2. CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. (PMID: 26100672) Russell M.R. … Cole K.A. (Cancer Res. 2015) 2 3 64
  3. Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. (PMID: 25367360) Li Q. … Guggenheim J.A. (Hum. Genet. 2014) 3 64
  4. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PMID: 23284291) Hancock D.B. … London S.J. (PLoS Genet. 2012) 3 64
  5. Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. (PMID: 22941191) Diskin S.J. … Maris J.M. (Nat. Genet. 2012) 3 64

Products for CASC15 Gene

Sources for CASC15 Gene

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