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Aliases for CASC10 Gene

Aliases for CASC10 Gene

  • Cancer Susceptibility 10 2 3 5
  • Cancer Susceptibility Candidate Gene 10 Protein 3 4
  • Cancer Susceptibility Candidate 10 2 3
  • C10orf114 3 4
  • Chromosome 10 Open Reading Frame 114 2
  • Protein CASC10 3
  • BA418C1.3 3

External Ids for CASC10 Gene

Previous HGNC Symbols for CASC10 Gene

  • C10orf114

Previous GeneCards Identifiers for CASC10 Gene

  • GC10M021788

Summaries for CASC10 Gene

GeneCards Summary for CASC10 Gene

CASC10 (Cancer Susceptibility 10) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC10 Gene

Genomics for CASC10 Gene

Regulatory Elements for CASC10 Gene

Enhancers for CASC10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G021515 2.7 FANTOM5 ENCODE dbSUPER 14.7 -21.0 -20954 6.3 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF263 SP3 CASC10 MIR1915 MLLT10 SKIDA1 GC10P021497
GH10G021522 1.7 FANTOM5 ENCODE dbSUPER 11.4 -29.1 -29091 7.4 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D MIR1915 CASC10 SKIDA1 MLLT10
GH10G021278 1.5 Ensembl ENCODE dbSUPER 11.2 +214.3 214333 9.3 HDGF PKNOX1 FOXA2 MLX ZNF133 ARID4B ZNF2 ZNF48 ETS1 TCF12 RNU6-15P ENSG00000199222 MIR1915 CASC10 NEBL GC10P021323 LUZP4P1
GH10G021723 1.3 Ensembl ENCODE 12.4 -227.3 -227318 2.3 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 SP3 ZNF610 SMARCA4 CASC10 MIR1915 MLLT10 RNU6-1141P BMI1 GC10P021711 RN7SKP219
GH10G021726 1.3 Ensembl ENCODE 12.4 -230.4 -230421 2.1 ATF1 PKNOX1 ARNT FEZF1 TCF12 ZNF766 GATA2 ZNF302 NCOA1 TSHZ1 CASC10 MIR1915 MLLT10 GC10P021711 RN7SKP219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CASC10 on UCSC Golden Path with GeneCards custom track

Promoters for CASC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025393 1284 3600 HNRNPUL1 MLX ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for CASC10 Gene

Chromosome:
10
Start:
21,492,658 bp from pter
End:
21,497,284 bp from pter
Size:
4,627 bases
Orientation:
Minus strand

Genomic View for CASC10 Gene

Genes around CASC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC10 Gene

Proteins for CASC10 Gene

  • Protein details for CASC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4H9-CSC10_HUMAN
    Recommended name:
    Protein CASC10
    Protein Accession:
    Q5T4H9
    Secondary Accessions:
    • A1L4M3

    Protein attributes for CASC10 Gene

    Size:
    136 amino acids
    Molecular mass:
    14851 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CASC10 Gene

Post-translational modifications for CASC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CASC10 Gene

Domains & Families for CASC10 Gene

Protein Domains for CASC10 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CASC10: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CASC10 Gene

Function for CASC10 Gene

Phenotypes for CASC10 Gene

GenomeRNAi human phenotypes for CASC10:
genes like me logo Genes that share phenotypes with CASC10: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CASC10 Gene

Localization for CASC10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASC10 gene
Compartment Confidence
extracellular 2
plasma membrane 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CASC10 Gene

Pathways & Interactions for CASC10 Gene

SuperPathways for CASC10 Gene

No Data Available

Interacting Proteins for CASC10 Gene

Selected Interacting proteins: Q5T4H9-CSC10_HUMAN for CASC10 Gene via IID

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for CASC10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CASC10 Gene

Transcripts for CASC10 Gene

mRNA/cDNA for CASC10 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CASC10 Gene

No ASD Table

Relevant External Links for CASC10 Gene

GeneLoc Exon Structure for
CASC10
ECgene alternative splicing isoforms for
CASC10

Expression for CASC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CASC10 Gene

mRNA differential expression in normal tissues according to GTEx for CASC10 Gene

This gene is overexpressed in Liver (x4.6).

Protein differential expression in normal tissues from HIPED for CASC10 Gene

This gene is overexpressed in Kidney (40.1) and Plasma (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CASC10 Gene



Protein tissue co-expression partners for CASC10 Gene

NURSA nuclear receptor signaling pathways regulating expression of CASC10 Gene:

CASC10
genes like me logo Genes that share expression patterns with CASC10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASC10 Gene

Orthologs for CASC10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CASC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASC10 34 35
  • 99.51 (n)
Species where no ortholog for CASC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CASC10 Gene

ENSEMBL:
Gene Tree for CASC10 (if available)
TreeFam:
Gene Tree for CASC10 (if available)

Paralogs for CASC10 Gene

No data available for Paralogs for CASC10 Gene

Variants for CASC10 Gene

Sequence variations from dbSNP and Humsavar for CASC10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000030795 -- 21,495,920(+) GGGGC(C/T)CCGGT reference, missense
rs1001054791 -- 21,496,694(+) CCGCG(C/G)CCTGG intron-variant, upstream-variant-2KB
rs1002004225 -- 21,498,150(+) TCTTA(C/T)GACTC upstream-variant-2KB
rs1002033129 -- 21,498,545(+) GTTAA(A/G)AATAG upstream-variant-2KB
rs1003519675 -- 21,495,273(+) GACGA(C/G)AGTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CASC10 Gene

Variant ID Type Subtype PubMed ID
dgv133n67 CNV gain 20364138
dgv134n67 CNV gain 20364138
dgv135n67 CNV gain 20364138
esv3622584 CNV loss 21293372
nsv517469 CNV loss 19592680
nsv527055 CNV loss 19592680
nsv550200 CNV loss 21841781
nsv825289 CNV loss 20364138

Variation tolerance for CASC10 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASC10 Gene

Disorders for CASC10 Gene

Relevant External Links for CASC10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASC10

No disorders were found for CASC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASC10 Gene

Publications for CASC10 Gene

  1. Common variation at 10p12.31 near MLLT10 influences meningioma risk. (PMID: 21804547) Dobbins S.E. … Houlston R.S. (Nat. Genet. 2011) 2 3 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for CASC10 Gene

Sources for CASC10 Gene

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