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Aliases for CASC10 Gene

Aliases for CASC10 Gene

  • Cancer Susceptibility Candidate 10 2 3 5
  • Cancer Susceptibility Candidate Gene 10 Protein 3 4
  • C10orf114 3 4
  • Chromosome 10 Open Reading Frame 114 2
  • BA418C1.3 3

External Ids for CASC10 Gene

Previous HGNC Symbols for CASC10 Gene

  • C10orf114

Previous GeneCards Identifiers for CASC10 Gene

  • GC10M021788

Summaries for CASC10 Gene

GeneCards Summary for CASC10 Gene

CASC10 (Cancer Susceptibility Candidate 10) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC10 Gene

Genomics for CASC10 Gene

Regulatory Elements for CASC10 Gene

Promoters for CASC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CASC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CASC10 Gene

Chromosome:
10
Start:
21,492,658 bp from pter
End:
21,497,284 bp from pter
Size:
4,627 bases
Orientation:
Minus strand

Genomic View for CASC10 Gene

Genes around CASC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC10 Gene

Proteins for CASC10 Gene

  • Protein details for CASC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4H9-CSC10_HUMAN
    Recommended name:
    Protein CASC10
    Protein Accession:
    Q5T4H9
    Secondary Accessions:
    • A1L4M3

    Protein attributes for CASC10 Gene

    Size:
    136 amino acids
    Molecular mass:
    14851 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CASC10 Gene

Proteomics data for CASC10 Gene at MOPED

Post-translational modifications for CASC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CASC10 Gene

Domains & Families for CASC10 Gene

Protein Domains for CASC10 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CASC10: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CASC10 Gene

Function for CASC10 Gene

Phenotypes for CASC10 Gene

GenomeRNAi human phenotypes for CASC10:
genes like me logo Genes that share phenotypes with CASC10: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CASC10 Gene

Localization for CASC10 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CASC10 Gene

Pathways & Interactions for CASC10 Gene

SuperPathways for CASC10 Gene

No Data Available

Interacting Proteins for CASC10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366317%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000366317 for CASC10 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for CASC10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CASC10 Gene

Drugs & Compounds for CASC10 Gene

No Compound Related Data Available

Transcripts for CASC10 Gene

mRNA/cDNA for CASC10 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CASC10 Gene

No ASD Table

Relevant External Links for CASC10 Gene

GeneLoc Exon Structure for
CASC10
ECgene alternative splicing isoforms for
CASC10

Expression for CASC10 Gene

mRNA expression in normal human tissues for CASC10 Gene

mRNA differential expression in normal tissues according to GTEx for CASC10 Gene

This gene is overexpressed in Liver (x4.6).

Protein differential expression in normal tissues from HIPED for CASC10 Gene

This gene is overexpressed in Kidney (40.1) and Plasma (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CASC10 Gene



genes like me logo Genes that share expression patterns with CASC10: view

Protein tissue co-expression partners for CASC10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CASC10 Gene

Orthologs for CASC10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CASC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASC10 35
  • 99.51 (n)
  • 99.26 (a)
CASC10 36
  • 99 (a)
OneToOne
Species with no ortholog for CASC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CASC10 Gene

ENSEMBL:
Gene Tree for CASC10 (if available)
TreeFam:
Gene Tree for CASC10 (if available)

Paralogs for CASC10 Gene

No data available for Paralogs for CASC10 Gene

Variants for CASC10 Gene

Sequence variations from dbSNP and Humsavar for CASC10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11012724 - 21,495,793(+) GAACC(C/G)GGTGG reference, missense
rs11599337 -- 21,495,592(+) TCGCC(C/G)GGAAT utr-variant-3-prime
rs34585530 -- 21,498,805(+) ATTTT(-/T)CTCAT upstream-variant-2KB
rs34653518 -- 21,498,780(+) CTTTT(-/T)AAGTG upstream-variant-2KB
rs12770228 -- 21,494,705(+) CCCCT(A/G)GGGTG utr-variant-3-prime

Variation tolerance for CASC10 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASC10 Gene

HapMap Linkage Disequilibrium report
CASC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CASC10 Gene

Disorders for CASC10 Gene

Relevant External Links for CASC10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASC10

No disorders were found for CASC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASC10 Gene

Publications for CASC10 Gene

  1. Common variation at 10p12.31 near MLLT10 influences meningioma risk. (PMID: 21804547) Dobbins S.E. … Houlston R.S. (Nat. Genet. 2011) 2 3 67
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CASC10 Gene

Sources for CASC10 Gene

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