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Aliases for CASC10 Gene

Aliases for CASC10 Gene

  • Cancer Susceptibility Candidate 10 2 3 5
  • Cancer Susceptibility Candidate Gene 10 Protein 3 4
  • C10orf114 3 4
  • Chromosome 10 Open Reading Frame 114 2
  • Protein CASC10 3
  • BA418C1.3 3

External Ids for CASC10 Gene

Previous HGNC Symbols for CASC10 Gene

  • C10orf114

Previous GeneCards Identifiers for CASC10 Gene

  • GC10M021788

Summaries for CASC10 Gene

GeneCards Summary for CASC10 Gene

CASC10 (Cancer Susceptibility Candidate 10) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC10 Gene

Genomics for CASC10 Gene

Regulatory Elements for CASC10 Gene

Enhancers for CASC10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F021515 2.4 FANTOM5 ENCODE 14.7 -21.0 -20954 6.3 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 YY1 ZNF263 SP3 CASC10 MIR1915 MLLT10 SKIDA1 GC10P021497
GH10F021726 1.3 Ensembl ENCODE 12.4 -230.4 -230421 2.1 ATF1 PKNOX1 ARNT FEZF1 ZNF766 ZNF302 GATA2 NCOA1 TSHZ1 PPARG MIR1915 CASC10 MLLT10 GC10P021711 RN7SKP219
GH10F021723 1.3 Ensembl ENCODE 12.4 -227.3 -227331 2.4 ATF1 ARID4B SIN3A FEZF1 ZNF2 ZNF202 SP3 TSHZ1 ZNF518A ZNF610 MIR1915 CASC10 MLLT10 RNU6-1141P GC10P021711 RN7SKP219
GH10F021522 1.4 FANTOM5 ENCODE 11.4 -29.1 -29091 7.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MIR1915 CASC10 MLLT10 SKIDA1
GH10F022433 1.6 FANTOM5 Ensembl ENCODE 9.5 -939.0 -939017 5.8 PKNOX1 ATF1 SIN3A ZNF2 ZNF121 GLIS2 ZNF143 FOS ZNF202 ZNF263 BMI1 COMMD3 CASC10 MIR1915 HNRNPRP1 DNAJC1 GC10P022433 LOC100499489
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CASC10 on UCSC Golden Path with GeneCards custom track

Promoters for CASC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000351770 1384 3801 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5

Genomic Location for CASC10 Gene

Chromosome:
10
Start:
21,492,658 bp from pter
End:
21,497,284 bp from pter
Size:
4,627 bases
Orientation:
Minus strand

Genomic View for CASC10 Gene

Genes around CASC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC10 Gene

Proteins for CASC10 Gene

  • Protein details for CASC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4H9-CSC10_HUMAN
    Recommended name:
    Protein CASC10
    Protein Accession:
    Q5T4H9
    Secondary Accessions:
    • A1L4M3

    Protein attributes for CASC10 Gene

    Size:
    136 amino acids
    Molecular mass:
    14851 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CASC10 Gene

Post-translational modifications for CASC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CASC10 Gene

Domains & Families for CASC10 Gene

Protein Domains for CASC10 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CASC10: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CASC10 Gene

Function for CASC10 Gene

Phenotypes for CASC10 Gene

GenomeRNAi human phenotypes for CASC10:
genes like me logo Genes that share phenotypes with CASC10: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CASC10 Gene

Localization for CASC10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASC10 gene
Compartment Confidence
extracellular 2
plasma membrane 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CASC10 Gene

Pathways & Interactions for CASC10 Gene

SuperPathways for CASC10 Gene

No Data Available

Interacting Proteins for CASC10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366317%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000366317 Q5T4H9-CSC10_HUMAN for CASC10 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CASC10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CASC10 Gene

Transcripts for CASC10 Gene

mRNA/cDNA for CASC10 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASC10 Gene

No ASD Table

Relevant External Links for CASC10 Gene

GeneLoc Exon Structure for
CASC10
ECgene alternative splicing isoforms for
CASC10

Expression for CASC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CASC10 Gene

mRNA differential expression in normal tissues according to GTEx for CASC10 Gene

This gene is overexpressed in Liver (x4.6).

Protein differential expression in normal tissues from HIPED for CASC10 Gene

This gene is overexpressed in Kidney (40.1) and Plasma (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CASC10 Gene



Protein tissue co-expression partners for CASC10 Gene

NURSA nuclear receptor signaling pathways regulating expression of CASC10 Gene:

CASC10
genes like me logo Genes that share expression patterns with CASC10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CASC10 Gene

Orthologs for CASC10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CASC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASC10 34 35
  • 99.51 (n)
Species where no ortholog for CASC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CASC10 Gene

ENSEMBL:
Gene Tree for CASC10 (if available)
TreeFam:
Gene Tree for CASC10 (if available)

Paralogs for CASC10 Gene

No data available for Paralogs for CASC10 Gene

Variants for CASC10 Gene

Sequence variations from dbSNP and Humsavar for CASC10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11012724 -- 21,495,793(+) GAACC(C/G)GGTGG reference, missense
rs111254375 -- 21,496,040(+) GAGGG(A/G)GCTTT intron-variant
rs112108427 -- 21,498,879(+) ACCAC(A/C)CAAAT upstream-variant-2KB
rs112329944 -- 21,496,084(+) GCGCC(C/T)TCCCC intron-variant, downstream-variant-500B
rs112411366 -- 21,494,316(+) GCCTC(A/G)GCGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CASC10 Gene

Variant ID Type Subtype PubMed ID
nsv825289 CNV loss 20364138
nsv550200 CNV loss 21841781
nsv527055 CNV loss 19592680
nsv517469 CNV loss 19592680
esv3622584 CNV loss 21293372
dgv135n67 CNV gain 20364138
dgv134n67 CNV gain 20364138
dgv133n67 CNV gain 20364138

Variation tolerance for CASC10 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASC10 Gene

Disorders for CASC10 Gene

Relevant External Links for CASC10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASC10

No disorders were found for CASC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASC10 Gene

Publications for CASC10 Gene

  1. Common variation at 10p12.31 near MLLT10 influences meningioma risk. (PMID: 21804547) Dobbins S.E. … Houlston R.S. (Nat. Genet. 2011) 2 3 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for CASC10 Gene

Sources for CASC10 Gene

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