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Aliases for CASC1 Gene

Aliases for CASC1 Gene

  • Cancer Susceptibility Candidate 1 2 3
  • Cancer Susceptibility Candidate Gene 1 Protein 3 4
  • Lung Adenoma Susceptibility 1-Like Protein 3 4
  • LAS1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 54 3
  • Cancer Susceptibility Candidate Protein 1 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 54 2
  • Protein CASC1 3
  • PPP1R54 3

External Ids for CASC1 Gene

Summaries for CASC1 Gene

GeneCards Summary for CASC1 Gene

CASC1 (Cancer Susceptibility Candidate 1) is a Protein Coding gene. Diseases associated with CASC1 include adenoma and lung adenoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC1 Gene

Genomics for CASC1 Gene

Genomic Location for CASC1 Gene

Start:
25,108,289 bp from pter
End:
25,195,162 bp from pter
Size:
86,874 bases
Orientation:
Minus strand

Genomic View for CASC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC1 Gene

Regulatory Elements for CASC1 Gene

Proteins for CASC1 Gene

  • Protein details for CASC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6TDU7-CASC1_HUMAN
    Recommended name:
    Protein CASC1
    Protein Accession:
    Q6TDU7
    Secondary Accessions:
    • B4DNP2
    • F5H6T6
    • Q17RL2
    • Q4G171
    • Q5U5K5
    • Q9NV50

    Protein attributes for CASC1 Gene

    Size:
    716 amino acids
    Molecular mass:
    83160 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91908.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91908.1; Type=Frameshift; Positions=438; Evidence={ECO:0000305};

    Alternative splice isoforms for CASC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASC1 Gene

Proteomics data for CASC1 Gene at MOPED

Post-translational modifications for CASC1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CASC1 Gene

Domains for CASC1 Gene

Gene Families for CASC1 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for CASC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CASC1_HUMAN
Family:
  • Belongs to the CASC1 family.:
    • Q6TDU7
genes like me logo Genes that share domains with CASC1: view

Function for CASC1 Gene

Gene Ontology (GO) - Molecular Function for CASC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding --
GO:0048487 beta-tubulin binding --
genes like me logo Genes that share ontologies with CASC1: view
genes like me logo Genes that share phenotypes with CASC1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CASC1 Gene

Localization for CASC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASC1 Gene COMPARTMENTS Subcellular localization image for CASC1 gene
Compartment Confidence
nucleus 3
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CASC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005881 cytoplasmic microtubule --
genes like me logo Genes that share ontologies with CASC1: view

Pathways for CASC1 Gene

SuperPathways for CASC1 Gene

No Data Available

Interacting Proteins for CASC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379310%0d%0a9606.ENSP00000326031%0d%0a
Selected Interacting proteins: ENSP00000379310 for CASC1 Gene via STRING

Symbol External ID(s) Details
PPP1CA

Gene Ontology (GO) - Biological Process for CASC1 Gene

None

No data available for Pathways by source for CASC1 Gene

Transcripts for CASC1 Gene

Unigene Clusters for CASC1 Gene

Cancer susceptibility candidate 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1: -
SP2:
SP3: - - - - -

Relevant External Links for CASC1 Gene

GeneLoc Exon Structure for
CASC1
ECgene alternative splicing isoforms for
CASC1

Expression for CASC1 Gene

mRNA expression in normal human tissues for CASC1 Gene

mRNA differential expression in normal tissues according to GTEx for CASC1 Gene

This gene is overexpressed in Testis (14.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CASC1 Gene

SOURCE GeneReport for Unigene cluster for CASC1 Gene Hs.407771

genes like me logo Genes that share expressions with CASC1: view

Orthologs for CASC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CASC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASC1 36
  • 99.35 (n)
  • 98.88 (a)
CASC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CASC1 36
  • 86.55 (n)
  • 80.25 (a)
CASC1 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CASC1 36
  • 88.63 (n)
  • 83.44 (a)
CASC1 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Casc1 36
  • 70.85 (n)
  • 68.27 (a)
Casc1 16
Casc1 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CASC1 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CASC1 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casc1 36
  • 70.29 (n)
  • 68.69 (a)
chicken
(Gallus gallus)
Aves CASC1 37
  • 48 (a)
OneToOne
LOC101750345 36
  • 62.55 (n)
  • 53.93 (a)
lizard
(Anolis carolinensis)
Reptilia CASC1 37
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii casc1 36
  • 51.56 (n)
  • 41.23 (a)
casc1 37
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToOne
Species with no ortholog for CASC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASC1 Gene

ENSEMBL:
Gene Tree for CASC1 (if available)
TreeFam:
Gene Tree for CASC1 (if available)

Paralogs for CASC1 Gene

No data available for Paralogs for CASC1 Gene

Variants for CASC1 Gene

Sequence variations from dbSNP and Humsavar for CASC1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1683160 -- 25,110,817(-) AAAAC(A/G)TTTAA intron-variant
rs1693360 -- 25,113,419(+) gcctc(A/G)gcctc intron-variant
rs1908948 -- 25,108,889(+) TAGCA(A/G)ATTAT intron-variant
rs1908949 -- 25,108,940(+) TAAAA(A/G)AAACA intron-variant
rs2200402 -- 25,126,340(-) ATTAG(A/G)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASC1 Gene

Variant ID Type Subtype PubMed ID
nsv469169 CNV Gain 19166990
esv2471634 CNV Deletion 19546169
esv2678918 CNV Deletion 23128226
nsv515612 CNV Gain 19592680
nsv898922 CNV Loss 21882294
esv2652823 CNV Deletion 19546169
esv2064539 CNV Deletion 18987734
esv2656765 CNV Deletion 23128226
nsv53768 CNV Loss 16902084

Relevant External Links for CASC1 Gene

HapMap Linkage Disequilibrium report
CASC1

Disorders for CASC1 Gene

(2) MalaCards Diseases for CASC1 Gene

Search for CASC1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CASC1 Gene

Relevant External Links for CASC1

Genetic Association Database (GAD)
CASC1
Human Genome Epidemiology (HuGE) Navigator
CASC1
genes like me logo Genes that share disorders with CASC1: view

No data available for UniProtKB/Swiss-Prot for CASC1 Gene

Publications for CASC1 Gene

  1. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. (PMID: 14583591) Zhang Z. … You M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  2. A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients. (PMID: 16410263) Manenti G. … Dragani T.A. (Carcinogenesis 2006) 3 4 49
  3. Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias. (PMID: 18299280) Kohno T. … Yokota J. (Carcinogenesis 2008) 3 49
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 49

Products for CASC1 Gene

Sources for CASC1 Gene

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