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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARTPT Gene

protein-coding   GIFtS: 56
GCID: GC05P071051

CART Prepropeptide

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CART Prepropeptide1 2
CART2 3 5
Cocaine And Amphetamine Regulated Transcript1 2
Cocaine- And Amphetamine-Regulated Transcript Protein2

External Ids:    HGNC: 243231   Entrez Gene: 96072   Ensembl: ENSG000001643267   OMIM: 6026065   UniProtKB: Q165683   

Export aliases for CARTPT gene to outside databases

Previous GC identifer: GC05P066220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CARTPT Gene:
This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller,
biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as
cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in
this gene are associated with susceptibility to obesity.(provided by RefSeq, Nov 2009)

GeneCards Summary for CARTPT Gene: 
CARTPT (CART prepropeptide) is a protein-coding gene. Diseases associated with CARTPT include human immunodeficiency virus infectious disease, and neurogenic bowel. GO annotations related to this gene include protein binding and molecular_function.

UniProtKB/Swiss-Prot: CART_HUMAN, Q16568
Function: Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide
inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by
neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in
vitro




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARTPT gene promoter:
         AhR   STAT1   p53   AP-1   ATF-2   C/EBPalpha   Arnt   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCARTPT promoter sequence
   Search SABiosciences Chromatin IP Primers for CARTPT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARTPT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.2

CARTPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARTPT gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P071051:  view genomic region     (about GC identifiers)

Start:
71,014,990 bp from pter      End:
71,016,875 bp from pter
Size:
1,886 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CART_HUMAN, Q16568 (See protein sequence)
Recommended Name: Cocaine- and amphetamine-regulated transcript protein precursor  
Size: 116 amino acids; 12829 Da
Subcellular location: Secreted (Potential)
1 PDB 3D structure from and Proteopedia for CARTPT:
1HY9 (3D)    
Secondary accessions: Q6FG92

Explore the universe of human proteins at neXtProt for CARTPT: NX_Q16568

Explore proteomics data for CARTPT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16568

  • CARTPT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CARTPT Protein Expression
    REFSEQ proteins: NP_004282.1  
    ENSEMBL proteins: 
     ENSP00000296777  

    Human Recombinant Protein Products for CARTPT: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for CARTPT
    OriGene MassSpec for CARTPT 
    OriGene Custom Protein Services for CARTPT
    GenScript Custom Purified and Recombinant Proteins Services for CARTPT
    Novus Biologicals CARTPT Protein
    Novus Biologicals CARTPT Lysate
    Sino Biological Recombinant Protein for CARTPT
    Sino Biological Cell Lysate for CARTPT 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--
    GO:0030141secretory granule IDA--

    CARTPT for ontologies           About GeneDecksing



    CARTPT Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CARTPT
    R&D Systems Antibodies for CARTPT (CART)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CARTPT
    GenScript Custom Superior Antibodies Services for CARTPT
    Novus Biologicals CARTPT Antibodies
    Search for Antibodies for CARTPT at Abcam
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CARTPT
    LSBio Antibodies in human, mouse, rat for CARTPT 

    Assay Products for CARTPT: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CARTPT
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009106 CART

    Graphical View of Domain Structure for InterPro Entry Q16568

    ProtoNet protein and cluster: Q16568

    1 Blocks protein domain: IPB009106 CART satiety factor

    UniProtKB/Swiss-Prot: CART_HUMAN, Q16568
    Similarity: Belongs to the CART family


    CARTPT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CART_HUMAN, Q16568
    Function: Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide
    inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by
    neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in
    vitro
    Induction: By leptin

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    CARTPT for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CARTPT:
     G0/1 arrest  Increased G1 DNA content 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cartpt):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  skeleton 

    CARTPT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CARTPT: Cartpttm1Hmh Cartpttm1Amgn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CARTPT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CARTPT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CARTPT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARTPT 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARTPT
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CARTPT (see all 9):
    hsa-miR-548am hsa-miR-548d-3p hsa-let-7a-2* hsa-miR-3924 hsa-miR-493* hsa-miR-377 hsa-miR-548x hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidCARTPT 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CARTPT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARTPT

    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CARTPT 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARTPT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CARTPT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CARTPT
        Selected targets of CREB1





    CARTPT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CARTPT

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for CARTPT (Q165681, 3 ENSP000002967774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEACAM1P136881, ENSP000001615594EBI-4314526,EBI-4314481 STRING: ENSP00000161559
    CEACAM6P401991, ENSP000001997644EBI-4314526,EBI-4314501 STRING: ENSP00000199764
    NPYP013033I2D: score=1 
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity ISS15908120
    GO:0001678cellular glucose homeostasis IDA11711504
    GO:0007165signal transduction TAS8647455
    GO:0007186G-protein coupled receptor signaling pathway ISS15908120
    GO:0007218neuropeptide signaling pathway IEA--

    CARTPT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CARTPT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CARTPT available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SHA 68Selective neuropeptide S receptor antagonist[847553-89-3]
    CART (55-102) (rat)Neuromodulatory neuropeptide fragment; satiety factor[209615-79-2]
    CART (62-76) (rat, human) Neuromodulating neuropeptide fragment; inhibits food intake in vivo[210978-19-1]
    CART (55-102) (human)Neuromodulatory neuropeptide fragment; satiety factor[214050-22-3]
    Neuropeptide W-23 (human)Endogenous NPBW1 and NPBW2 receptor agonist[383415-79-0]

    1 DrugBank Compound for CARTPT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Amphetamine(+/-)-Benzedrine (see all 19)300-62-9targetagonist16713658 15661821 15597110 15680473 15644956 15680478

    4 Novoseek inferred chemical compound relationships for CARTPT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cocaine 76.6 28 17631364 (7), 16840648 (3), 8647455 (2), 16146347 (2) (see all 11)
    amphetamine 49.3 1 15051141 (1)
    cyclic amp 40 5 15207912 (2), 16766084 (1), 11948252 (1)
    dopamine 20 9 16840648 (3), 16146347 (2), 16766084 (1)

    Search CenterWatch for drugs/clinical trials and news about CARTPT / CART

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CARTPT gene: 
    NM_004291.3  

    Unigene Cluster for CARTPT:

    CART prepropeptide
    Hs.1707  [show with all ESTs]
    Unigene Representative Sequence: NM_004291
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296777(uc003kbv.2) ENST00000513096

    miRNA
    Products:
         
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CARTPT (see all 9):
    hsa-miR-548am hsa-miR-548d-3p hsa-let-7a-2* hsa-miR-3924 hsa-miR-493* hsa-miR-377 hsa-miR-548x hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidCARTPT 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CARTPT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARTPT
    Clone
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    OriGene clones in human, mouse for CARTPT (see all 10)
    OriGene ORF clones in mouse, rat for CARTPT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CARTPT (NM_004291)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARTPT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARTPT
    Sirion Biotech Customized lentivirus for stable overexpression of CARTPT 
                         Customized lentivirus expression plasmids for stable overexpression of CARTPT 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CARTPT
    OriGene qSTAR qPCR primer pairs in human, mouse for CARTPT
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CARTPT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARTPT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARTPT

    Additional mRNA sequence: 

    BC029882.1 CR542216.1 U16826.1 

    3 DOTS entries:

    DT.209075  DT.91721755  DT.95368333 

    24/40 AceView cDNA sequences (see all 40):

    CR542216 BX089832 AA319900 NM_004291 BC029882 CK300473 BI600308 BI598241 
    AI300511 AV727357 CK002678 BQ637725 AV751343 U16826 AI417979 BI600648 
    BI598030 BI828760 BI830032 AI016587 AA573715 BQ188016 AA587732 AV750910 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CARTPT expression in normal human tissues (normalized intensities)      CARTPT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAATTAT
    CARTPT Expression
    About this image


    CARTPT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Septum   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             visceral organ/lung/left lung   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Spinal Ventral Columns
     
     Peripheral Nervous System (Nervous System)
             autonomic/sympathetic/ganglion   

    See CARTPT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CARTPT

    SOURCE GeneReport for Unigene cluster: Hs.1707

    UniProtKB/Swiss-Prot: CART_HUMAN, Q16568
    Tissue specificity: Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the
    external zone of the median eminence, and also found in terminals in the periventricular part of the
    paraventricular nucleus

        SABiosciences Expression via Pathway-Focused PCR Arrays including CARTPT: 
              Circadian Rhythms in human mouse rat
              Obesity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARTPT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARTPT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CARTPT gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cartpt1 , 5 CART prepropeptide1, 5 92.82(n)1
    96.55(a)1
      13 (52.90 cM)5
    272201  NM_013732.61  NP_038760.31 
     998984845 
    chicken
    (Gallus gallus)
    Aves LOC1008584881 cocaine- and amphetamine-regulated transcript protein-like 69.09(n)
    72.73(a)
      100858488  XM_003643097.1  XP_003643145.1 
    lizard
    (Anolis carolinensis)
    Reptilia CARTPT6
    Uncharacterized protein
    81(a)
    1 ↔ 1
    2(16752214-16756800)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.129132 Transcribed sequence with weak similarity to protein more 74.85(n)    BX720906.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.296272 Transcribed sequence with weak similarity to protein more 73.43(n)    CK400425.1 


    ENSEMBL Gene Tree for CARTPT (if available)
    TreeFam Gene Tree for CARTPT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/137 SNPs in CARTPT are shown (see all 137)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219090651,2
    C,Fother171308807(+) GTCTTG/CAAGAA 2 /F /L mis12Minor allele frequency- C:0.00NA EU 5873
    VAR_0121994
    ----see VAR_0121992 L F mis40--------
    rs605044961,2
    C--71017119(+) AGAGA-/GAGA  
            
    AAGAG
    1 -- ds50011Minor allele frequency- GAGA:0.50CSA 2
    rs37631551,2
    C,F,H--71306325(-) CTGTGG/CGGTAA 1 -- us2k115Minor allele frequency- C:0.11NA EA NS WA CSA 1280
    rs1148278961,2
    --71306472(+) ACTATC/GTTAAT 1 -- us2k10--------
    rs38573831,2
    C,F,A,H--71306493(+) ATCTGA/C/G/
            
    TACGC
    1 -- us2k17NA WA EA 366
    rs64531321,2
    C,F,A,H--71306496(+) TGCTAA/C/G/
            
    GCAAT
    1 -- us2k1 tfbs310WA NA CSA EA 369
    rs1478582731,2
    --71306532(+) AGATGA/GTTTGG 1 -- us2k10--------
    rs68594381,2
    C,F,H--71306543(+) ATTGAG/ATAGTC 1 -- us2k119Minor allele frequency- A:0.11NS EA NA WA CSA 2336
    rs37631541,2
    C,F,A,H--71306554(-) taaatA/C/G/
            
    tcTAT
    1 -- us2k129NS EA NA WA CSA 2620

    HapMap Linkage Disequilibrium report for CARTPT (71014990 - 71016875 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CARTPT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4872CNV Insertion18451855


    Human Gene Mutation Database (HGMD): CARTPT
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CARTPT
    DNA2.0 Custom Variant and Variant Library Synthesis for CARTPT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602606   
    OMIM disorders: 601665  
    20 diseases for CARTPT:    About MalaCards
    human immunodeficiency virus infectious disease    neurogenic bowel    anus cancer    progressive multifocal leukoencephalopathy
    cocaine abuse    cocaine dependence    nicotine dependence    obesity
    autism spectrum disorder    lipodystrophy    anorexia nervosa    bipolar disorder
    alcoholism    dementia    diabetes mellitus    schizophrenia
    hypertension    multiple sclerosis    neuronitis    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for CARTPT:
    Acquired immunodeficiency syndrome     Lipodystrophy     Anus cancer     Tuberculosis

    CARTPT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for CARTPT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 27.4 4 15234472 (2), 16146347 (1)
    obesity 24.2 11 10905499 (4), 15519893 (2), 16840648 (1)

    Genetic Association Database (GAD): CARTPT
    Human Genome Epidemiology (HuGE) Navigator: CARTPT (27 documents)

    Export disorders for CARTPT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CARTPT gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with CARTPT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript. (PubMed id 8647455)1, 2, 3, 9 Douglass J.O. and Daoud S. (1996)
    2. Hypothalamic CART is a new anorectic peptide regulated by leptin. (PubMed id 9590691)1, 2, 3 Kristensen P.... Hastrup S. (1998)
    3. The CART gene and human obesity: mutational analysis and population genetics. (PubMed id 10905499)1, 2, 9 Challis B.G.... O'Rahilly S. (2000)
    4. Cocaine and amphetamine regulated transcript (CART) g ene in the comorbidity of schizophrenia with alcohol use disorders and nicotine dependence. (PubMed id 20362026)1, 4 Busto A....Kennedy J.L. (2010)
    5. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    6. Molecular analysis of the CART gene in overweight and obese Italian children using family-based association methods. (PubMed id 20151954)1, 4 Rigoli L....Salpietro C. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Genetic risk factors in typical haemolytic uraemic syndrome. (PubMed id 19110485)1, 4 Taranta A....Emma F. (2009)
    9. Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Stud y. (PubMed id 19876004)1, 4 Corpeleijn E....Blaak E.E. (2009)
    10. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9607 HGNC: 24323 AceView: CART Ensembl:ENSG00000164326 euGenes: HUgn9607
    ECgene: CARTPT H-InvDB: CARTPT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CARTPT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CARTPT gene:
    Search GeneIP for patents involving CARTPT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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