CARTPT Gene

Aliases
for CARTPT gene

Previous GC identifer: GC05P066220

Summaries
for CARTPT gene

Genomic Views
for CARTPT gene

RefSeq DNA sequence:

NC_000005.9  NC_018916.1  NT_006713.15  

SwitchGear Promoter luciferase reporter plasmid: CARTPT promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARTPT

CARTPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P071051:  view genomic region     (about GC identifiers)

Proteins
for CARTPT gene

1 PDB 3D structure from and Proteopedia for CARTPT:

1HY9 (3D)    

Explore the universe of human proteins at neXtProt for CARTPT: NX_Q16568

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CARTPT OriGene Protein Over-expression Lysate: CARTPT OriGene Custom Protein Services for CARTPT
	GenScript Custom Purified and Recombinant Proteins Services for CARTPT
	Novus Biologicals CARTPT Protein Novus Biologicals CARTPT Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CARTPT

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CARTPT
	R&D Systems Antibodies for CARTPT (CART)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CARTPT
	GenScript Custom Superior Antibodies Services for CARTPT
	Novus Biologicals CARTPT Antibodies
	Search for Antibodies for CARTPT at Abcam
	Uscn Antibodies for CARTPT
	Search ThermoFisher Antibodies for CARTPT

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CARTPT
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CARTPT

Protein Domains /
Families
for CARTPT gene

ProtoNet protein and cluster: Q16568

Function
for CARTPT gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARTPT
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CARTPT (see all 9):
		hsa-miR-548am hsa-miR-548d-3p hsa-let-7a-2* hsa-miR-3924 hsa-miR-493* hsa-miR-377 hsa-miR-548x hsa-let-7g*
		SwitchGear 3'UTR luciferase reporter plasmid: CARTPT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARTPT (see all 7) OriGene shRNA RFP: CARTPT OriGene siRNA: CARTPT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARTPT

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CARTPT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARTPT (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARTPT (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CARTPT (NM_004291)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARTPT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARTPT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CARTPT
		Search LifeMap BioReagents cell lines for CARTPT

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARTPT

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Cartpt)

Pathways & Interactions
for CARTPT gene

	Super-pathway	contained gene-specific pathways
1	Selected targets of CREB1	Selected targets of CREB1 1.00

1 EMD Millipore Pathway for CARTPT

Selected targets of CREB1

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

Drugs & Compounds
for CARTPT gene

Transcripts
for CARTPT gene

Expression
for CARTPT gene

CARTPT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAAATTAT

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor Cells			Motor Neurons
	Neural TubeMetencephalon			Neural Tube
	Spinal CordSpinal Ventral Columns			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARTPT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CARTPT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARTPT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARTPT

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARTPT

Orthologs
for CARTPT gene

Paralogs
for CARTPT gene

Genomic Variants
for CARTPT gene

10/114 NCBI SNPs in CARTPT are shown (see all 114)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1219090651,2	C,F	other	66221671(+)	GTCTTG/CAAGAA	2	/F /L	mis1		2		NA EU	5873
rs1124827751,2		--	66219535(+)	TAGAGA/G/TACCAG	1	--	us2k1		2		CSA NA	122
rs1112923251,2		--	66219649(+)	GGAATC/TTAGAT	1	--	us2k1		2		CSA WA	120
rs105151141,2	C,F,H,	--	66219775(-)	CTTAAT/CGTCTA	1	--	us2k1		15		NS NA EA CSA WA	904
rs362237711,2	C,	--	66219806(-)	CAACCC/GAGTCC	1	--	us2k1		0	--	--	--	--
rs1165840391,2	C,F,	--	66219918(+)	CATTGC/TTTTTC	1	--	us2k1		1		WA	118
rs737639331,2	C,	--	66220045(+)	ATTTTC/TATAAT	1	--	us2k1		1		WA	2
rs362234411,2	C,F,	--	66220397(-)	GGTGTC/TGGAAG	1	--	us2k1		2		CSA	4
rs2013044601,2	C	--	66220590(+)	TTCTCA/CCCGCC	1	--	us2k1		0	--	--	--	--
rs68947581,2	C,F,A,H,	--	66220653(+)	AGCTGT/CCACCA	1	--	us2k1		23		NS EA NA WA CSA	2747

HapMap Linkage Disequilibrium report for CARTPT (71014990 - 71016875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CARTPT: --
Human Gene Mutation Database (HGMD): CARTPT

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARTPT

DNA2.0 Custom Variant and Variant Library Synthesis for CARTPT

Disorders / Diseases
for CARTPT gene

20/23 diseases for CARTPT

2 Novoseek disease relationships for CARTPT gene    About this table

Publications
for CARTPT gene

PubMed articles for CARTPT gene, integrated from 9 sources (see all 75): (articles sorted by number of sources associating them with CARTPT)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript. (PubMed id 8647455)^{1, 2, 3, 9} Douglass J.O. and Daoud S. (1996)
2. Hypothalamic CART is a new anorectic peptide regulated by leptin. (PubMed id 9590691)^{1, 2, 3} Kristensen P.... Hastrup S. (1998)
3. The CART gene and human obesity: mutational analysis and population genetics. (PubMed id 10905499)^{1, 2, 9} Challis B.G.... O'Rahilly S. (2000)
4. Melanocortin-4 receptor gene and physical activity in the Quebec Family Study. (PubMed id 15597110)^{1, 7} Loos R.J....Bouchard C. (2005)
5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold. (PubMed id 11478874)^{1, 2} Ludvigsen S.... Wulff B.S. (2001)
8. Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. (PubMed id 11522684)^{1, 2} del Giudice E.M....Perrone L. (2001)
9. CART mRNA expression in rat monkey and human brain: relevance to cocaine abuse. (PubMed id 17631364)^{1, 9} Fagergren P. and Hurd Y. (2007)
10. Cocaine- and amphetamine-regulated transcript peptides play a role in drug abuse and are potential therapeutic targets. (PubMed id 16146347)^{1, 9} Kuhar M.J....Dominguez G. (2005)

External Searches for CARTPT gene

Genome Databases showing CARTPT gene

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Products
for CARTPT gene