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Aliases for CARTPT Gene

Aliases for CARTPT Gene

  • CART Prepropeptide 2 3
  • CART 3 4 6
  • Cocaine And Amphetamine Regulated Transcript 2 3
  • Cocaine- And Amphetamine-Regulated Transcript Protein 3

External Ids for CARTPT Gene

Summaries for CARTPT Gene

Entrez Gene Summary for CARTPT Gene

  • This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in this gene are associated with susceptibility to obesity.[provided by RefSeq, Nov 2009]

GeneCards Summary for CARTPT Gene

CARTPT (CART Prepropeptide) is a Protein Coding gene. Diseases associated with CARTPT include anus cancer and obesity, susceptibility to, cartpt-related.

UniProtKB/Swiss-Prot for CARTPT Gene

  • Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARTPT Gene

Genomics for CARTPT Gene

Genomic Location for CARTPT Gene

Start:
71,719,163 bp from pter
End:
71,721,048 bp from pter
Size:
1,886 bases
Orientation:
Plus strand

Genomic View for CARTPT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARTPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARTPT Gene

Regulatory Elements for CARTPT Gene

Proteins for CARTPT Gene

  • Protein details for CARTPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16568-CART_HUMAN
    Recommended name:
    Cocaine- and amphetamine-regulated transcript protein
    Protein Accession:
    Q16568
    Secondary Accessions:
    • Q6FG92

    Protein attributes for CARTPT Gene

    Size:
    116 amino acids
    Molecular mass:
    12829 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CARTPT Gene

neXtProt entry for CARTPT Gene

Proteomics data for CARTPT Gene at MOPED

Post-translational modifications for CARTPT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARTPT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CARTPT Gene

Domains for CARTPT Gene

Protein Domains for CARTPT Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CART_HUMAN
Family:
  • Belongs to the CART family.:
    • Q16568
genes like me logo Genes that share domains with CARTPT: view

No data available for Gene Families for CARTPT Gene

Function for CARTPT Gene

Molecular function for CARTPT Gene

UniProtKB/Swiss-Prot Function: Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.
UniProtKB/Swiss-Prot Induction: By leptin

Gene Ontology (GO) - Molecular Function for CARTPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CARTPT: view
genes like me logo Genes that share phenotypes with CARTPT: view

Animal Models for CARTPT Gene

MGI Knock Outs for CARTPT:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CARTPT Gene

Localization for CARTPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARTPT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARTPT Gene COMPARTMENTS Subcellular localization image for CARTPT gene
Compartment Confidence
extracellular 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CARTPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0030141 secretory granule IDA 21624661
genes like me logo Genes that share ontologies with CARTPT: view

Pathways for CARTPT Gene

SuperPathways for CARTPT Gene

No Data Available

Interacting Proteins for CARTPT Gene

Gene Ontology (GO) - Biological Process for CARTPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity ISS 15908120
GO:0001678 cellular glucose homeostasis IDA 11711504
GO:0007165 signal transduction TAS 8647455
GO:0007186 G-protein coupled receptor signaling pathway ISS 15908120
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with CARTPT: view

No data available for Pathways by source for CARTPT Gene

Compounds for CARTPT Gene

(5) Tocris Compounds for CARTPT Gene

Compound Action Cas Number
CART (55-102) (human) Neuromodulatory neuropeptide fragment; satiety factor [214050-22-3]
CART (55-102) (rat) Neuromodulatory neuropeptide fragment; satiety factor [209615-79-2]
CART (62-76) (rat, human) Neuromodulating neuropeptide fragment; inhibits food intake in vivo [210978-19-1]
Neuropeptide W-23 (human) Endogenous NPBW1 and NPBW2 receptor agonist [383415-79-0]
SHA 68 Selective neuropeptide S receptor antagonist [847553-89-3]

(1) Drugbank Compounds for CARTPT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Amphetamine
  • (+/-)-Benzedrine
300-62-9 target agonist

(4) Novoseek inferred chemical compound relationships for CARTPT Gene

Compound -log(P) Hits PubMed IDs
cocaine 76.6 21
amphetamine 49.3 1
cyclic amp 40 4
dopamine 20 6
genes like me logo Genes that share compounds with CARTPT: view

Transcripts for CARTPT Gene

mRNA/cDNA for CARTPT Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARTPT Gene

CART prepropeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARTPT Gene

No ASD Table

Relevant External Links for CARTPT Gene

GeneLoc Exon Structure for
CARTPT
ECgene alternative splicing isoforms for
CARTPT

Expression for CARTPT Gene

mRNA expression in normal human tissues for CARTPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CARTPT Gene

This gene is overexpressed in Brain - Hypothalamus (19.3), Artery - Aorta (7.6), and Brain - Frontal Cortex (BA9) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CARTPT Gene

SOURCE GeneReport for Unigene cluster for CARTPT Gene Hs.1707

mRNA Expression by UniProt/SwissProt for CARTPT Gene

Q16568-CART_HUMAN
Tissue specificity: Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus
genes like me logo Genes that share expressions with CARTPT: view

Orthologs for CARTPT Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARTPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CARTPT 36
  • 99.14 (n)
  • 99.14 (a)
CARTPT 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CARTPT 36
  • 92.88 (n)
  • 97.75 (a)
CARTPT 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARTPT 36
  • 86.21 (n)
  • 88.79 (a)
CARTPT 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cartpt 36
  • 92.82 (n)
  • 96.55 (a)
Cartpt 16
Cartpt 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CARTPT 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cartpt 36
  • 91.09 (n)
  • 94.83 (a)
chicken
(Gallus gallus)
Aves CARTL 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CARTPT 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cartpt 36
  • 71.54 (n)
  • 75.28 (a)
Str.12913 36
zebrafish
(Danio rerio)
Actinopterygii cart1 37
  • 55 (a)
OneToMany
cart2 37
  • 56 (a)
OneToMany
cart4 37
  • 41 (a)
OneToMany
CARTPT (1 of 4) 37
  • 48 (a)
OneToMany
Dr.29627 36
Species with no ortholog for CARTPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARTPT Gene

ENSEMBL:
Gene Tree for CARTPT (if available)
TreeFam:
Gene Tree for CARTPT (if available)

Paralogs for CARTPT Gene

No data available for Paralogs for CARTPT Gene

Variants for CARTPT Gene

Sequence variations from dbSNP and Humsavar for CARTPT Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1800926 -- 71,720,621(+) AGGGG(C/G)GTCCA utr-variant-3-prime
rs2239670 -- 71,719,676(+) CAGGG(A/G)CCCCA intron-variant
rs3763153 -- 71,717,820(-) GTTCT(A/C/G/T)CCACT upstream-variant-2KB
rs3763154 -- 71,717,650(-) taaat(A/C/G/T)tcTAT upstream-variant-2KB
rs3763155 -- 71,717,421(-) CTGTG(C/G)GGTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CARTPT Gene

Variant ID Type Subtype PubMed ID
nsv4872 CNV Insertion 18451855

Relevant External Links for CARTPT Gene

HapMap Linkage Disequilibrium report
CARTPT
Human Gene Mutation Database (HGMD)
CARTPT

Disorders for CARTPT Gene

(1) OMIM Diseases for CARTPT Gene (602606)

(4) University of Copenhagen DISEASES for CARTPT Gene

(2) Novoseek inferred disease relationships for CARTPT Gene

Disease -log(P) Hits PubMed IDs
alcoholism 27.4 3
obesity 24.2 7

Relevant External Links for CARTPT

Genetic Association Database (GAD)
CARTPT
Human Genome Epidemiology (HuGE) Navigator
CARTPT
genes like me logo Genes that share disorders with CARTPT: view

No data available for UniProtKB/Swiss-Prot for CARTPT Gene

Publications for CARTPT Gene

  1. Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript. (PMID: 8647455) Douglass J.O. … Daoud S. (Gene 1996) 2 3 4 23
  2. The CART gene and human obesity: mutational analysis and population genetics. (PMID: 10905499) Challis B.G. … O'Rahilly S. (Diabetes 2000) 3 4 23
  3. Hypothalamic CART is a new anorectic peptide regulated by leptin. (PMID: 9590691) Kristensen P. … Hastrup S. (Nature 1998) 2 3 4
  4. Association between polymorphism in intron 1 of cocaine- and amphetamine-regulated transcript gene with alcoholism, but not with bipolar disorder and schizophrenia in Korean population. (PMID: 15234472) Jung S.K. … Yim S.V. (Neurosci. Lett. 2004) 3 23
  5. Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence. (PMID: 18572320) Lohoff F.W. … Berrettini W.H. (Neurosci. Lett. 2008) 3 49

Products for CARTPT Gene

Sources for CARTPT Gene

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