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Aliases for CARTPT Gene

Aliases for CARTPT Gene

  • CART Prepropeptide 2 3 5
  • CART 3 4
  • Cocaine And Amphetamine Regulated Transcript 2

External Ids for CARTPT Gene

Previous GeneCards Identifiers for CARTPT Gene

  • GC05P071051
  • GC05P066220

Summaries for CARTPT Gene

Entrez Gene Summary for CARTPT Gene

  • This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]

GeneCards Summary for CARTPT Gene

CARTPT (CART Prepropeptide) is a Protein Coding gene. Diseases associated with CARTPT include Obesity and Obesity, Susceptibility To, Cartpt-Related. Among its related pathways are Glucose / Energy Metabolism and Neuroscience.

UniProtKB/Swiss-Prot for CARTPT Gene

  • Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.

Tocris Summary for CARTPT Gene

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARTPT Gene

Genomics for CARTPT Gene

Regulatory Elements for CARTPT Gene

Enhancers for CARTPT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CARTPT on UCSC Golden Path with GeneCards custom track

Genomic Location for CARTPT Gene

Chromosome:
5
Start:
71,719,163 bp from pter
End:
71,721,048 bp from pter
Size:
1,886 bases
Orientation:
Plus strand

Genomic View for CARTPT Gene

Genes around CARTPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARTPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARTPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARTPT Gene

Proteins for CARTPT Gene

  • Protein details for CARTPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16568-CART_HUMAN
    Recommended name:
    Cocaine- and amphetamine-regulated transcript protein
    Protein Accession:
    Q16568
    Secondary Accessions:
    • Q6FG92

    Protein attributes for CARTPT Gene

    Size:
    116 amino acids
    Molecular mass:
    12829 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CARTPT Gene

neXtProt entry for CARTPT Gene

Proteomics data for CARTPT Gene at MOPED

Post-translational modifications for CARTPT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARTPT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CARTPT (CARTPT)

No data available for DME Specific Peptides for CARTPT Gene

Domains & Families for CARTPT Gene

Protein Domains for CARTPT Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CARTPT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16568

UniProtKB/Swiss-Prot:

CART_HUMAN :
  • Belongs to the CART family.
Family:
  • Belongs to the CART family.
genes like me logo Genes that share domains with CARTPT: view

No data available for Gene Families for CARTPT Gene

Function for CARTPT Gene

Molecular function for CARTPT Gene

UniProtKB/Swiss-Prot Function:
Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.
UniProtKB/Swiss-Prot Induction:
By leptin.
genes like me logo Genes that share phenotypes with CARTPT: view

Animal Models for CARTPT Gene

MGI Knock Outs for CARTPT:

Animal Model Products

  • Taconic Biosciences Mouse Models for CARTPT

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CARTPT Gene

Localization for CARTPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARTPT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARTPT Gene COMPARTMENTS Subcellular localization image for CARTPT gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CARTPT Gene

Pathways & Interactions for CARTPT Gene

genes like me logo Genes that share pathways with CARTPT: view

Pathways by source for CARTPT Gene

2 Cell Signaling Technology pathways for CARTPT Gene

Interacting Proteins for CARTPT Gene

Gene Ontology (GO) - Biological Process for CARTPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity ISS 15908120
GO:0001678 cellular glucose homeostasis IEA,IDA 11711504
GO:0007165 signal transduction TAS 8647455
GO:0007186 G-protein coupled receptor signaling pathway IEA,ISS 15908120
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with CARTPT: view

No data available for SIGNOR curated interactions for CARTPT Gene

Drugs & Compounds for CARTPT Gene

(4) Drugs for CARTPT Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amphetamine Approved, Illicit Pharma antagonist, Target, agonist 106

(5) Additional Compounds for CARTPT Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Antagonist G
115150-59-9
CART (55-102) (human)
214050-22-3
CART (55-102) (rat)
209615-79-2
Neuropeptide W-23 (human)
383415-79-0
Obestatin (rat)
869705-22-6

(5) Tocris Compounds for CARTPT Gene

Compound Action Cas Number
Antagonist G Broad spectrum neuropeptide receptor antagonist 115150-59-9
CART (55-102) (human) Neuromodulatory neuropeptide fragment; satiety factor 214050-22-3
CART (55-102) (rat) Neuromodulatory neuropeptide fragment; satiety factor 209615-79-2
Neuropeptide W-23 (human) Endogenous NPBW1 and NPBW2 receptor agonist 383415-79-0
Obestatin (rat) Endogenous reported anorexigenic peptide 869705-22-6
genes like me logo Genes that share compounds with CARTPT: view

Transcripts for CARTPT Gene

mRNA/cDNA for CARTPT Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARTPT Gene

CART prepropeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARTPT Gene

No ASD Table

Relevant External Links for CARTPT Gene

GeneLoc Exon Structure for
CARTPT
ECgene alternative splicing isoforms for
CARTPT

Expression for CARTPT Gene

mRNA expression in normal human tissues for CARTPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CARTPT Gene

This gene is overexpressed in Brain - Hypothalamus (x19.3), Artery - Aorta (x7.6), and Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for CARTPT Gene

This gene is overexpressed in Breast (46.6), Vitreous humor (7.8), and Colon (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CARTPT Gene



SOURCE GeneReport for Unigene cluster for CARTPT Gene Hs.1707

mRNA Expression by UniProt/SwissProt for CARTPT Gene

Q16568-CART_HUMAN
Tissue specificity: Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus.
genes like me logo Genes that share expression patterns with CARTPT: view

Primer Products

No data available for Protein tissue co-expression partners for CARTPT Gene

Orthologs for CARTPT Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARTPT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CARTPT 35
  • 92.88 (n)
  • 97.75 (a)
CARTPT 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARTPT 35
  • 86.21 (n)
  • 88.79 (a)
CARTPT 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cartpt 35
  • 92.82 (n)
  • 96.55 (a)
Cartpt 16
Cartpt 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CARTPT 35
  • 99.14 (n)
  • 99.14 (a)
CARTPT 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cartpt 35
  • 91.09 (n)
  • 94.83 (a)
oppossum
(Monodelphis domestica)
Mammalia CARTPT 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CARTL 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CARTPT 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cartpt 35
  • 71.54 (n)
  • 75.28 (a)
Str.12913 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29627 35
cart1 36
  • 55 (a)
OneToMany
cart2 36
  • 56 (a)
OneToMany
cart4 36
  • 41 (a)
OneToMany
CARTPT (1 of 4) 36
  • 48 (a)
OneToMany
Species with no ortholog for CARTPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARTPT Gene

ENSEMBL:
Gene Tree for CARTPT (if available)
TreeFam:
Gene Tree for CARTPT (if available)

Paralogs for CARTPT Gene

No data available for Paralogs for CARTPT Gene

Variants for CARTPT Gene

Sequence variations from dbSNP and Humsavar for CARTPT Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_012199 -
rs78242624 - 71,719,917(+) CAAGA(A/C/G)TAAAC reference, missense
rs12517689 - 71,720,601(+) TCCTC(A/C)TGAAG reference, missense
rs6859438 -- 71,717,639(+) ATTGA(A/G)TAGTC upstream-variant-2KB
rs3763153 -- 71,717,820(-) GTTCT(A/C/G/T)CCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CARTPT Gene

Variant ID Type Subtype PubMed ID
nsv4872 CNV Insertion 18451855

Variation tolerance for CARTPT Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARTPT Gene

Human Gene Mutation Database (HGMD)
CARTPT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARTPT Gene

Disorders for CARTPT Gene

MalaCards: The human disease database

(9) MalaCards diseases for CARTPT Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
obesity, susceptibility to, cartpt-related
human immunodeficiency virus infectious disease
cocaine abuse
  • cocaine-related disorders
anus cancer
  • anal cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CARTPT

Genetic Association Database (GAD)
CARTPT
Human Genome Epidemiology (HuGE) Navigator
CARTPT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARTPT
genes like me logo Genes that share disorders with CARTPT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CARTPT Gene

Publications for CARTPT Gene

  1. Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript. (PMID: 8647455) Douglass J.O. … Daoud S. (Gene 1996) 2 3 4 23 67
  2. Melanocortin-4 receptor gene and physical activity in the QuAcbec Family Study. (PMID: 15597110) Loos R.J. … Bouchard C. (Int J Obes (Lond) 2005) 3 25 26
  3. CART mRNA expression in rat monkey and human brain: relevance to cocaine abuse. (PMID: 17631364) Fagergren P. … Hurd Y. (Physiol. Behav. 2007) 3 23
  4. The CART receptors: background and recent advances. (PMID: 16713658) Vicentic A. … Jones D. (Peptides 2006) 25 26
  5. Cocaine- and amphetamine-regulated transcript peptides play a role in drug abuse and are potential therapeutic targets. (PMID: 16146347) Kuhar M.J. … Dominguez G. (AAPS J 2005) 3 23

Products for CARTPT Gene

Sources for CARTPT Gene

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