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CARS2 Gene

protein-coding   GIFtS: 57
GCID: GC13M111293

Cysteinyl-TRNA Synthetase 2, Mitochondrial (Putative)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cysteinyl-TRNA Synthetase 2, Mitochondrial (Putative)1 2     Cysteine--TRNA Ligase2
EC 6.1.1.163 8     Probable Cysteine--TRNA Ligase, Mitochondrial2
Cysteine TRNA Ligase 21     Probable Cysteinyl-TRNA Synthetase, Mitochondrial2
Mitochondrial (Putative)1     CysRS3
cysRS2     Cysteinyl-TRNA Synthetase3
Cysteine TRNA Ligase 2, Mitochondrial (Putative)2     EC 6.1.18

External Ids:    HGNC: 256951   Entrez Gene: 795872   Ensembl: ENSG000001349057   OMIM: 6128005   UniProtKB: Q9HA773   
ORGUL members:         

Export aliases for CARS2 gene to outside databases

Previous GC identifers: GC13M110092 GC13M091893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CARS2 Gene:
CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial (putative)) is a protein-coding gene. Diseases associated with CARS2 include pneumonia, and tuberculosis. GO annotations related to this gene include cysteine-tRNA ligase activity. An important paralog of this gene is CARS.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CARS2 gene promoter:
         Egr-3   ISGF-3   Spz1   RREB-1   LUN-1   HNF-4alpha2   Nkx2-5   HNF-4alpha1   E47   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CARS2 promoter sequence
   Search Chromatin IP Primers for CARS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

CARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARS2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M111293:  view genomic region     (about GC identifiers)

Start:
111,293,757 bp from pter      End:
111,365,950 bp from pter
Size:
72,194 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYCM_HUMAN, Q9HA77 (See protein sequence)
Recommended Name: Probable cysteine--tRNA ligase, mitochondrial precursor  
Size: 564 amino acids; 62224 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Sequence caution: Sequence=BAB93499.1; Type=Erroneous initiation;
Secondary accessions: Q8NI84 Q96IV4

Explore the universe of human proteins at neXtProt for CARS2: NX_Q9HA77

Explore proteomics data for CARS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CARS2 (Q9HA77) (see all 11)
     EKMSKSL  LWKAAKP  DKIIKRA  FPHHENE 


    See CARS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078813.1  
    ENSEMBL proteins: 
     ENSP00000257347   ENSP00000438267   ENSP00000443027   ENSP00000440420   ENSP00000444655  
     ENSP00000437962  
    Reactome Protein details: Q9HA77

    CARS2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CARS2

    CARS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    CARS2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CARS2
    Cloud-Clone Corp. CLIAs for CARS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS1: Aminoacyl tRNA synthetases / Class I

    4 InterPro protein domains:
     IPR024909 Cys-tRNA/MSH_ligase
     IPR015803 Cys-tRNA-ligase
     IPR009080 tRNAsynth_1a_anticodon-bd
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry Q9HA77

    ProtoNet protein and cluster: Q9HA77

    1 Blocks protein domain: IPB002308 Cysteinyl-tRNA synthetase signature

    UniProtKB/Swiss-Prot: SYCM_HUMAN, Q9HA77
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    CARS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYCM_HUMAN, Q9HA77
    Catalytic activity: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

         Enzyme Numbers (IUBMB): EC 6.1.1.161 2 EC 6.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004817cysteine-tRNA ligase activity IBA--
    GO:0004824lysine-tRNA ligase activity ----
    GO:0005524ATP binding IEA--
         
    CARS2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cars2):
     behavior/neurological  hearing/vestibular/ear  nervous system 

    CARS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CARS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CARS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CARS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CARS2:
    hsa-mir-155-5p (MIRT020814), hsa-mir-30d-5p (MIRT047820), hsa-mir-26b-5p (MIRT029604)

    Block miRNA regulation of human, mouse, rat CARS2 using miScript Target Protectors
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CARS2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CARS2 (see all 7)
    OriGene ORF clones in mouse, rat for CARS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CARS2 (NM_024537)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARS2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CARS2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYCM_HUMAN, Q9HA77: Mitochondrion matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005759mitochondrial matrix IEA--
    GO:0005829cytosol IBA--

    CARS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CARS2 About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.52
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CARS2
        Mitochondrial tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for CARS2):
        Aminoacyl-tRNA biosynthesis


    CARS2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CARS2
    Interactions:

        Search GeneGlobe Interaction Network for CARS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CARS2 (Q9HA773 ENSP000002573474) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRMT10CQ7L0Y33, ENSP000003123564I2D: score=1 STRING: ENSP00000312356
    RCC1ENSP000003629374STRING: ENSP00000362937
    RANENSP000003961274STRING: ENSP00000396127
    YARSENSP000003625764STRING: ENSP00000362576
    PASKENSP000002340404STRING: ENSP00000234040
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006423cysteinyl-tRNA aminoacylation IBA--
    GO:0006430lysyl-tRNA aminoacylation ----
    GO:0010467gene expression TAS--

    CARS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CARS2 (SYCM)

    5 HMDB Compounds for CARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for CARS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Cysteine(R)-2-Amino-3-mercaptopropanoic acid (see all 13)52-90-4target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CARS2 gene: 
    NM_024537.2  

    Unigene Cluster for CARS2:

    Cysteinyl-tRNA synthetase 2, mitochondrial (putative)
    Hs.508725  [show with all ESTs]
    Unigene Representative Sequence: BC082264
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000541239 ENST00000540006 ENST00000375781 ENST00000257347(uc001vrd.2)
    ENST00000535516 ENST00000537802 ENST00000481787 ENST00000542774 ENST00000487253
    ENST00000471986 ENST00000480437 ENST00000535615 ENST00000535398(uc010tjm.1)
    ENST00000540215 ENST00000543487 ENST00000541362 ENST00000537386 ENST00000545506

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate CARS2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CARS2
    Predesigned siRNA for gene silencing in human, mouse, rat CARS2
    Clone
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    OriGene clones in human, mouse for CARS2 (see all 7)
    OriGene ORF clones in mouse, rat for CARS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CARS2 (NM_024537)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARS2
    Primer
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    OriGene qPCR primer pairs and template standards for CARS2
    OriGene qSTAR qPCR primer pairs in human, mouse for CARS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CARS2
      QuantiTect SYBR Green Assays in human, mouse, rat CARS2
      QuantiFast Probe-based Assays in human, mouse, rat CARS2

    Additional mRNA sequence: 

    AB062436.1 AK022180.1 AK301907.1 BC007220.1 BC041586.1 BC042958.1 BC082264.1 

    Selected DOTS entries (see all 32):

    DT.100717845  DT.453937  DT.306030  DT.101983096  DT.92038223  DT.97788599  DT.100029395  DT.100827726 
    DT.95261602  DT.100029391  DT.100029394  DT.95261594  DT.120787551  DT.120787563  DT.75141450  DT.91696048 
    DT.99964540  DT.100808052  DT.91814226  DT.100837264  DT.95255321  DT.100827728  DT.100827730  DT.120787562 

    Selected AceView cDNA sequences (see all 332):

    AA551660 CR594413 BC041586 AI264792 BM976365 CD672590 AI675466 AL709950 
    AI702293 NM_024537 BE222182 CR613047 CR615939 CR614128 AL520832 AK022180 
    CR605547 BU626795 CR623160 AA306163 AI168090 AI420850 BG912142 AW082247 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CARS2 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
    SP1:                          -     -           -           -     -                                               -     -                           
    SP2:                                            -     -     -     -     -           -     -     -     -           -     -                           
    SP3:                                            -                 -     -                                         -     -           -               
    SP4:                          -     -           -           -     -     -                                                                           
    SP5:        -     -     -     -     -           -                                                                                                   


    ECgene alternative splicing isoforms for CARS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CARS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CARS2 Expression
    About this image

    CARS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CARS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508725
        Custom PCR Arrays for CARS2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CARS2
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    QuantiTect SYBR Green Assays in human, mouse, rat CARS2
    QuantiFast Probe-based Assays in human, mouse, rat CARS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CARS2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cars21 , 5 cysteinyl-tRNA synthetase 2 (mitochondrial)(putative)1, 5 78.39(n)1
    79.67(a)1
      8 (5.73 cM)5
    719411  NM_024248.11  NP_077210.11 
     115140215 
    chicken
    (Gallus gallus)
    Aves CARS21 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 68.38(n)
    66.36(a)
      418757  XM_004938539.1  XP_004938596.1 
    lizard
    (Anolis carolinensis)
    Reptilia CARS26
    cysteinyl-tRNA synthetase 2, mitochondrial (putati...
    61(a)
    1 ↔ 1
    3(104452605-104489487)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060463.12   -- 73.48(n)    BC060463.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF996441.12   -- 72.09(n)    CF996441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82571 CG8257 50.37(n)
    43.18(a)
      36563  NM_137086.3  NP_610930.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Cysteinyl-tRNA synthetase; may interact with ribos...
    25(a)
    1 → many
    XIV(182875-185178) YNL247W
    rice
    (Oryza sativa)
    Liliopsida Os10g04631001 Os10g0463100 50.42(n)
    43.44(a)
      4348825  NM_001071320.2  NP_001064785.2 


    ENSEMBL Gene Tree for CARS2 (if available)
    TreeFam Gene Tree for CARS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CARS2 gene
    CARS2  
    3 SIMAP similar genes for CARS2 using alignment to 6 protein entries:     SYCM_HUMAN (see all proteins):
    DKFZp667A2315    DKFZp686G08243    CNOT2

    CARS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CARS2 (see all 1756)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3699702541,2
    --91901595(+) CGACT-/GTTTTT 1 -- int10--------
    rs1908867781,2
    --111293281(+) CCCCAC/TCACTG 1 -- int10--------
    rs1512072241,2
    C--111293344(+) TGCAGC/TGGGAC 1 -- int10--------
    rs1166809441,2
    C,F--111293355(+) TGCAGA/GCGGGT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1890931,2
    C,F,A,H--111293411(-) GTTTTC/TTCTCT 1 -- int120Minor allele frequency- T:0.08NS EA NA CSA WA EU 2819
    rs1447965931,2
    C--111293489(+) GACTA-/TGCATGCT 1 -- cds10--------
    rs769193151,2
    C,F--111293496(+) GCTGCG/ATGGCC 1 -- int13Minor allele frequency- A:0.10CSA WA EA 240
    rs2005325911,2
    C--111293496(+) CTGCG-/CATGGCC 1 -- int10--------
    rs619704951,2
    C--111293499(+) GCGTGG/ACCCAC 1 -- int12Minor allele frequency- A:0.13NA 122
    rs102201631,2
    C,F--111293542(+) AGGAAA/GCAGGC 1 -- int14Minor allele frequency- G:0.17WA CSA 124

    HapMap Linkage Disequilibrium report for CARS2 (111293757 - 111365950 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CARS2 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748035CNV Deletion23290073
    esv2748036CNV Deletion23290073
    esv2663401CNV Deletion23128226
    esv991840CNV Deletion20482838
    esv1319128CNV Deletion17803354
    dgv267e201CNV Deletion23290073
    esv2748042CNV Deletion23290073
    esv2748039CNV Deletion23290073
    esv2748037CNV Deletion23290073
    esv2748043CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 612800    OMIM disorders: --

    3 diseases for CARS2:    
    About MalaCards
    pneumonia    tuberculosis    malaria


    CARS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CARS2
    Human Genome Epidemiology (HuGE) Navigator: CARS2 (2 documents)

    Export disorders for CARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CARS2 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 2, 3 Bonnefond L....Sissler M. (Biochemistry 2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    9. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 79587 HGNC: 25695 AceView: FLJ12118 Ensembl:ENSG00000134905 euGenes: HUgn79587
    ECgene: CARS2 Kegg: 79587 H-InvDB: CARS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CARS2 gene:
    Search GeneIP for patents involving CARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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