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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARS2 Gene

protein-coding   GIFtS: 56
GCID: GC13M111293

Cysteinyl-TRNA Synthetase 2, Mitochondrial (Putative)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cysteinyl-TRNA Synthetase 2, Mitochondrial (Putative)1 2     Cysteine--TRNA Ligase2
EC 6.1.1.163 8     Probable Cysteine--TRNA Ligase, Mitochondrial2
Cysteine TRNA Ligase 21     Probable Cysteinyl-TRNA Synthetase, Mitochondrial2
Mitochondrial (Putative)1     CysRS3
cysRS2     Cysteinyl-TRNA Synthetase3
Cysteine TRNA Ligase 2, Mitochondrial (Putative)2     EC 6.1.18

External Ids:    HGNC: 256951   Entrez Gene: 795872   Ensembl: ENSG000001349057   OMIM: 6128005   UniProtKB: Q9HA773   

Export aliases for CARS2 gene to outside databases

Previous GC identifers: GC13M110092 GC13M091893


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CARS2 Gene: 
CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial (putative)) is a protein-coding gene. Diseases associated with CARS2 include pneumonia, and tuberculosis, and among its related super-pathways are Cytosolic tRNA aminoacylation and Generic Transcription Pathway. GO annotations related to this gene include cysteine-tRNA ligase activity and metal ion binding. An important paralog of this gene is CARS.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARS2 gene promoter:
         Egr-3   ISGF-3   Spz1   RREB-1   LUN-1   HNF-4alpha2   Nkx2-5   HNF-4alpha1   E47   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CARS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CARS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

CARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARS2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M111293:  view genomic region     (about GC identifiers)

Start:
111,293,757 bp from pter      End:
111,365,950 bp from pter
Size:
72,194 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYCM_HUMAN, Q9HA77 (See protein sequence)
Recommended Name: Probable cysteine--tRNA ligase, mitochondrial precursor  
Size: 564 amino acids; 62224 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Mitochondrion matrix (By similarity)
Sequence caution: Sequence=BAB93499.1; Type=Erroneous initiation;
Secondary accessions: Q8NI84 Q96IV4

Explore the universe of human proteins at neXtProt for CARS2: NX_Q9HA77

Explore proteomics data for CARS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HA77

  • 4/11 DME Specific Peptides for CARS2 (Q9HA77) (see all 11)
     EKMSKSL  LWKAAKP  DKIIKRA  FPHHENE 

    CARS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CARS2 Protein Expression
    REFSEQ proteins: NP_078813.1  
    ENSEMBL proteins: 
     ENSP00000257347   ENSP00000438267   ENSP00000443027   ENSP00000440420   ENSP00000444655  
     ENSP00000437962  
    Reactome Protein details: Q9HA77
    Human Recombinant Protein Products for CARS2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CARS2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005759mitochondrial matrix IEA--
    GO:0005829cytosol IBA--

    CARS2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CARS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    aaRS1: Aminoacyl tRNA synthetases / Class I

    4 InterPro protein domains:
     IPR024909 Cys-tRNA/MSH_ligase
     IPR015803 Cys-tRNA-ligase
     IPR009080 tRNAsynth_1a_anticodon-bd
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry Q9HA77

    ProtoNet protein and cluster: Q9HA77

    1 Blocks protein domain: IPB002308 Cysteinyl-tRNA synthetase signature

    UniProtKB/Swiss-Prot: SYCM_HUMAN, Q9HA77
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    CARS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYCM_HUMAN, Q9HA77
    Catalytic activity: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

         Enzyme Numbers (IUBMB): EC 6.1.1.161 2 EC 6.1.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004817cysteine-tRNA ligase activity IBA--
    GO:0004824lysine-tRNA ligase activity ----
    GO:0005524ATP binding IEA--
         
    CARS2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cars2):
     behavior/neurological  hearing/vestibular/ear  nervous system 

    CARS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CARS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CARS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CARS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARS2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CARS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.54
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for CARS2
        tRNA Aminoacylation
    Gene Expression
    Mitochondrial tRNA aminoacylation


    1         Kegg Pathway  (Kegg details for CARS2):
        Aminoacyl-tRNA biosynthesis


    CARS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CARS2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CARS2 (Q9HA773 ENSP000002573474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRMT10CQ7L0Y33, ENSP000003123564I2D: score=1 STRING: ENSP00000312356
    RPS20ENSP000000095894STRING: ENSP00000009589
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006423cysteinyl-tRNA aminoacylation IBA--
    GO:0006430lysyl-tRNA aminoacylation ----
    GO:0010467gene expression TAS--

    CARS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CARS2 (SYCM)

    5 HMDB Compounds for CARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for CARS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Cysteine(R)-2-Amino-3-mercaptopropanoic acid (see all 13)52-90-4target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about CARS2 / SYCM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CARS2 gene: 
    NM_024537.2  

    Unigene Cluster for CARS2:

    Cysteinyl-tRNA synthetase 2, mitochondrial (putative)
    Hs.508725  [show with all ESTs]
    Unigene Representative Sequence: BC082264
    18/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000541239 ENST00000540006 ENST00000375781 ENST00000257347(uc001vrd.2)
    ENST00000535516 ENST00000537802 ENST00000481787 ENST00000542774 ENST00000487253
    ENST00000471986 ENST00000480437 ENST00000535615 ENST00000535398(uc010tjm.1)
    ENST00000540215 ENST00000543487 ENST00000541362 ENST00000537386 ENST00000545506

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CARS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARS2
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    GenScript: all cDNA clones in your preferred vector: CARS2 (NM_024537)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARS2
    Sirion Biotech Customized lentivirus for stable overexpression of CARS2 
                         Customized lentivirus expression plasmids for stable overexpression of CARS2 
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    OriGene qPCR primer pairs and template standards for CARS2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARS2

    Additional mRNA sequence: 

    AB062436.1 AK022180.1 AK301907.1 BC007220.1 BC041586.1 BC042958.1 BC082264.1 

    24/32 DOTS entries (see all 32):

    DT.100717845  DT.453937  DT.306030  DT.101983096  DT.92038223  DT.97788599  DT.100029395  DT.100827726 
    DT.95261602  DT.100029391  DT.100029394  DT.95261594  DT.120787551  DT.120787563  DT.75141450  DT.91696048 
    DT.99964540  DT.100808052  DT.91814226  DT.100837264  DT.95255321  DT.100827728  DT.100827730  DT.120787562 

    24/332 AceView cDNA sequences (see all 332):

    AW301704 CR600317 BE782356 BM547336 CR593997 CD513429 BE550882 BU680782 
    CR626682 AI434818 BP343626 BU734229 AL521343 AI828623 BU543802 BM920093 
    AU121418 BQ897221 BF001947 BU608636 CB141319 AW192309 CA312383 BM463792 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CARS2 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
    SP1:                          -     -           -           -     -                                               -     -                           
    SP2:                                            -     -     -     -     -           -     -     -     -           -     -                           
    SP3:                                            -                 -     -                                         -     -           -               
    SP4:                          -     -           -           -     -     -                                                                           
    SP5:        -     -     -     -     -           -                                                                                                   


    ECgene alternative splicing isoforms for CARS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CARS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CARS2 Expression
    About this image


    See CARS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CARS2

    SOURCE GeneReport for Unigene cluster: Hs.508725
        SABiosciences Custom PCR Arrays for CARS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CARS2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cars21 , 5 cysteinyl-tRNA synthetase 2 (mitochondrial)(putative)1, 5 78.39(n)1
    79.67(a)1
      8 (5.73 cM)5
    719411  NM_024248.11  NP_077210.11 
     115140215 
    chicken
    (Gallus gallus)
    Aves CARS21 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 68.26(n)
    66.36(a)
      418757  XM_416955.3  XP_416955.3 
    lizard
    (Anolis carolinensis)
    Reptilia CARS26
    cysteinyl-tRNA synthetase 2, mitochondrial (putati...
    61(a)
    1 ↔ 1
    3(104452605-104489487)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060463.12   -- 73.48(n)    BC060463.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF996441.12   -- 72.09(n)    CF996441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82571 CG8257 49.83(n)
    42.57(a)
      36563  NM_137086.3  NP_610930.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNL247W6
    Cysteinyl-tRNA synthetase; may interact with ribos...
    19(a)
    1 → many
    XIV(182875-185178)


    ENSEMBL Gene Tree for CARS2 (if available)
    TreeFam Gene Tree for CARS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CARS2 gene
    CARS2  
    3 SIMAP similar genes for CARS2 using alignment to 6 protein entries:     SYCM_HUMAN (see all proteins):
    DKFZp667A2315    DKFZp686G08243    CNOT2

    CARS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1756 SNPs in CARS2 are shown (see all 1756)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3699702541,2
    --91901595(+) CGACT-/GTTTTT 1 -- int10--------
    rs1908867781,2
    --111293281(+) CCCCAC/TCACTG 1 -- int10--------
    rs1512072241,2
    C--111293344(+) TGCAGC/TGGGAC 1 -- int10--------
    rs1166809441,2
    C,F--111293355(+) TGCAGA/GCGGGT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1890931,2
    C,F,A,H--111293411(-) GTTTTC/TTCTCT 1 -- int120Minor allele frequency- T:0.08NS EA NA CSA WA EU 2819
    rs1447965931,2
    C--111293489(+) GACTA-/TGCATGCT 1 -- cds10--------
    rs769193151,2
    C,F--111293496(+) GCTGCG/ATGGCC 1 -- int13Minor allele frequency- A:0.10CSA WA EA 240
    rs2005325911,2
    C--111293496(+) CTGCG-/CATGGCC 1 -- int10--------
    rs619704951,2
    C--111293499(+) GCGTGG/ACCCAC 1 -- int12Minor allele frequency- A:0.13NA 122
    rs102201631,2
    C,F--111293542(+) AGGAAA/GCAGGC 1 -- int14Minor allele frequency- G:0.17WA CSA 124

    HapMap Linkage Disequilibrium report for CARS2 (111293757 - 111365950 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for CARS2 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748035CNV Deletion23290073
    esv2748036CNV Deletion23290073
    esv2663401CNV Deletion23128226
    esv991840CNV Deletion20482838
    esv1319128CNV Deletion17803354
    dgv267e201CNV Deletion23290073
    esv2748042CNV Deletion23290073
    esv2748039CNV Deletion23290073
    esv2748037CNV Deletion23290073
    esv2748043CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612800    OMIM disorders: --

    2 diseases for CARS2:    About MalaCards
    pneumonia    tuberculosis


    CARS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CARS2
    Human Genome Epidemiology (HuGE) Navigator: CARS2 (2 documents)

    Export disorders for CARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CARS2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 2, 3 Bonnefond L....Sissler M. (2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    9. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79587 HGNC: 25695 AceView: FLJ12118 Ensembl:ENSG00000134905 euGenes: HUgn79587
    ECgene: CARS2 Kegg: 79587 H-InvDB: CARS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CARS2 gene:
    Search GeneIP for patents involving CARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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