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Aliases for CARS Gene

Aliases for CARS Gene

  • Cysteinyl-TRNA Synthetase 4 2 3
  • EC 4 63
  • CysRS 3 4
  • Cysteine TRNA Ligase 1, Cytoplasmic 3
  • Cysteine TRNA Ligase 1 2
  • Cysteine Translase 3
  • Cytoplasmic 2
  • MGC:11246 3
  • EC 6.1.1 63
  • CARS1 3

External Ids for CARS Gene

Previous GeneCards Identifiers for CARS Gene

  • GC11M003081
  • GC11M003272
  • GC11M002981
  • GC11M002986
  • GC11M002978
  • GC11M002810

Summaries for CARS Gene

Entrez Gene Summary for CARS Gene

  • This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]

GeneCards Summary for CARS Gene

CARS (Cysteinyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with CARS include inflammatory myofibroblastic tumor and hypocalcemia, autosomal dominant. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include protein homodimerization activity and tRNA binding. An important paralog of this gene is CARS2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARS Gene

Genomics for CARS Gene

Regulatory Elements for CARS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CARS Gene

3,000,922 bp from pter
3,057,613 bp from pter
56,692 bases
Minus strand

Genomic View for CARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARS Gene

Proteins for CARS Gene

  • Protein details for CARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine--tRNA ligase, cytoplasmic
    Protein Accession:
    Secondary Accessions:
    • Q53XI8
    • Q5HYE4
    • Q9HD24
    • Q9HD25

    Protein attributes for CARS Gene

    748 amino acids
    Molecular mass:
    85473 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Monomer.
    • Sequence=AAA73901.1; Type=Frameshift; Positions=619; Evidence={ECO:0000305};

    Alternative splice isoforms for CARS Gene


neXtProt entry for CARS Gene

Proteomics data for CARS Gene at MOPED

Post-translational modifications for CARS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CARS Gene

Gene Families for CARS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-I aminoacyl-tRNA synthetase family.
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with CARS: view

Function for CARS Gene

Molecular function for CARS Gene

GENATLAS Biochemistry:
cysteinyl-tRNA synthetase,target autoantibodies in the immune disease polymyositis/dermatomyositis
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

Enzyme Numbers (IUBMB) for CARS Gene

Gene Ontology (GO) - Molecular Function for CARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding NAS 7987009
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004817 cysteine-tRNA ligase activity TAS --
GO:0005515 protein binding IPI 10908348
genes like me logo Genes that share ontologies with CARS: view
genes like me logo Genes that share phenotypes with CARS: view

miRNA for CARS Gene

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CARS Gene

Localization for CARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARS Gene


Subcellular locations from

Jensen Localization Image for CARS Gene COMPARTMENTS Subcellular localization image for CARS gene
Compartment Confidence
cytosol 5
cytoskeleton 2
extracellular 2
chloroplast 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11347887
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CARS: view

Pathways & Interactions for CARS Gene

genes like me logo Genes that share pathways with CARS: view

Pathways by source for CARS Gene

1 KEGG pathway for CARS Gene

Gene Ontology (GO) - Biological Process for CARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006423 cysteinyl-tRNA aminoacylation IDA 10908348
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with CARS: view

No data available for SIGNOR curated interactions for CARS Gene

Drugs & Compounds for CARS Gene

(8) Drugs for CARS Gene - From: HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Cysteine Approved Nutra Target 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
vitamin d Pharma 1463

(7) Additional Compounds for CARS Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with CARS: view

Transcripts for CARS Gene

Unigene Clusters for CARS Gene

Cysteinyl-tRNA synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP6: - - - -
SP7: - - -
SP9: -

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: - - - -
SP2: - - - -
SP3: - - -
SP8: -
SP12: -

Relevant External Links for CARS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARS Gene

mRNA expression in normal human tissues for CARS Gene

Protein differential expression in normal tissues from HIPED for CARS Gene

This gene is overexpressed in Lymph node (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARS Gene

SOURCE GeneReport for Unigene cluster for CARS Gene Hs.274873

genes like me logo Genes that share expression patterns with CARS: view

Protein tissue co-expression partners for CARS Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CARS Gene

Orthologs for CARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CARS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CARS 35
  • 81.22 (n)
  • 82.75 (a)
  • 82 (a)
(Canis familiaris)
Mammalia CARS 35
  • 85.44 (n)
  • 88.57 (a)
  • 89 (a)
(Mus musculus)
Mammalia Cars 35
  • 86.08 (n)
  • 89.65 (a)
Cars 16
Cars 36
  • 90 (a)
(Pan troglodytes)
Mammalia CARS 35
  • 99.56 (n)
  • 99.76 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cars 35
  • 85.35 (n)
  • 89.62 (a)
(Monodelphis domestica)
Mammalia CARS 36
  • 79 (a)
(Gallus gallus)
Aves CARS 35
  • 75.54 (n)
  • 82.3 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia CARS 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cars 35
  • 71.1 (n)
  • 76.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia cars-prov 35
(Danio rerio)
Actinopterygii cars 35
  • 68.98 (n)
  • 73.97 (a)
Dr.24192 35
cars 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD21177 37
  • 58 (a)
Aats-cys 35
  • 61.5 (n)
  • 60.72 (a)
Aats-cys 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012283 35
  • 60.04 (n)
  • 60.77 (a)
(Caenorhabditis elegans)
Secernentea crs-1 37
  • 53 (a)
cars-1 35
  • 56.93 (n)
  • 55.26 (a)
cars-1 36
  • 45 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03025g 35
  • 50.55 (n)
  • 47.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL247W 35
  • 51.67 (n)
  • 46.94 (a)
-- 36
  • 44 (a)
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SYCO ARATH 35
  • 47.79 (n)
  • 40.85 (a)
(Hordeum vulgare)
Liliopsida Hv.2722 35
(Oryza sativa)
Liliopsida Os09g0556500 35
  • 51.83 (n)
  • 48.71 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14611 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC29E6.06c 35
  • 50.7 (n)
  • 46.5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7234 36
  • 59 (a)
Species with no ortholog for CARS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CARS Gene

Gene Tree for CARS (if available)
Gene Tree for CARS (if available)

Paralogs for CARS Gene

Paralogs for CARS Gene

(2) SIMAP similar genes for CARS Gene using alignment to 7 proteins: Pseudogenes for CARS Gene

genes like me logo Genes that share paralogs with CARS: view

Variants for CARS Gene

Sequence variations from dbSNP and Humsavar for CARS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs80871 -- 3,028,613(+) GATGA(A/C)ATGCA intron-variant
rs80872 -- 3,028,754(+) TGGCT(G/T)CCGAG intron-variant
rs105686 -- 3,041,237(+) GGGAG(A/G)CGATA intron-variant
rs366422 -- 3,032,643(+) TTTTC(C/T)GATCT intron-variant
rs369461 -- 3,040,762(-) GAATC(A/G)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARS Gene

Variant ID Type Subtype PubMed ID
nsv8766 CNV Loss 18304495
nsv825716 CNV Gain 20364138
nsv819979 CNV Loss 19587683
esv2668116 CNV Deletion 23128226

Variation tolerance for CARS Gene

Residual Variation Intolerance Score: 52.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARS Gene

Disorders for CARS Gene

MalaCards: The human disease database

(4) MalaCards diseases for CARS Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
inflammatory myofibroblastic tumor
  • inflammatory fibrosarcoma
hypocalcemia, autosomal dominant
  • hypocalcemia, autosomal dominant, with bartter syndrome
childhood disintegrative disease
  • disintegrative psychosis nos
x-linked chondrodysplasia punctata
  • chondrodystrophia calcificans congenita
- elite association
Search CARS in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.

Relevant External Links for CARS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CARS: view

No data available for Genatlas for CARS Gene

Publications for CARS Gene

  1. Assignment of the cysteinyl-tRNA synthetase gene (CARS) to 11p15.5. (PMID: 8468064) Cruzen M.E. … Arfin S.M. (Genomics 1993) 2 23 67
  2. Residue 826 in the calcium-sensing receptor is implicated in the response to calcium and to R-568 calcimimetic compound. (PMID: 20130845) Alvarez-HernA!ndez D. … Cannata-AndA-a J.B. (Calcif. Tissue Int. 2010) 23 67
  3. Proteomic analysis of Rickettsia parkeri strain portsmouth. (PMID: 19797064) Pornwiroon W. … Macaluso K.R. (Infect. Immun. 2009) 23 67
  4. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. (PMID: 19252134) Pezzolesi M.G. … Krolewski A.S. (Diabetes 2009) 23 67
  5. HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway. (PMID: 18285520) Lee J.I. … Stipanuk M.H. (Physiol. Genomics 2008) 23 67

Products for CARS Gene

Sources for CARS Gene

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