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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARS Gene

protein-coding   GIFtS: 66
GCID: GC11M003022

cysteinyl-tRNA synthetase
 Explore 29 diseases affiliated with
CARS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CARS    

Aliases
for CARS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cysteinyl-TRNA Synthetase1 2 3     Cysteine Translase2
CARS11 2     Cysteine TRNA Ligase 1, Cytoplasmic2
EC 6.1.1.163 8     Cysteine--TRNA Ligase, Cytoplasmic2
CYSRS2     CysRS3
MGC:112462     EC 6.1.18

External Ids:    HGNC: 14931   Entrez Gene: 8332   Ensembl: ENSG000001106197   OMIM: 1238595   UniProtKB: P495893   
ORGUL members:         
NONCODE:n410111    

Export aliases for CARS gene to outside databases

Previous GC identifers: GC11M003081 GC11M003272 GC11M002981 GC11M002986 GC11M002978 GC11M002810


Summaries
for CARS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CARS:
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA
synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.
This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important
tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms
tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this
gene results in multiple transcript variants. (provided by RefSeq, Aug 2010)




Genomic Views
for CARS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARS gene promoter:
         RORalpha1   POU2F1   POU2F1a   Nkx2-5   Nkx5-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CARS promoter sequence
   Search SABiosciences Chromatin IP Primers for CARS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

CARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003022:  view genomic region     (about GC identifiers)

Start:
 3,022,152 bp from pter      End:
 3,078,843 bp from pter
Size:
 56,692 bases      Orientation:
 minus strand

Proteins
for CARS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SYCC_HUMAN, P49589 (See protein sequence)
Recommended Name: Cysteine--tRNA ligase, cytoplasmic  
Size: 748 amino acids; 85473 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAA73901.1; Type=Frameshift; Positions=619;
Secondary accessions: Q53XI8 Q5HYE4 Q9HD24 Q9HD25
Alternative splicing: 3 isoforms:  P49589-1   P49589-2   P49589-3   (Contains a phosphoserine at position 79)

Explore the universe of human proteins at neXtProt for CARS: NX_P49589

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49589

    • 4/21 DME Specific Peptides for CARS (P49589) (see all 21)
     QLRLAFL  DKIIKRA  DFALWKA  LHLYNSL 

    CARS Protein expression data from MOPED and PaxDb:    About this image 
    CARS Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001014437.1  NP_001181926.1  NP_001742.1  NP_644802.1  

    ENSEMBL proteins: 
     ENSP00000369897   ENSP00000431368   ENSP00000380300   ENSP00000278224   ENSP00000432619  
     ENSP00000408802   ENSP00000434184   ENSP00000380303   ENSP00000384069  
    Reactome Protein details: P49589
    Human Recombinant Protein Products for CARS: 
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    Novus Biologicals CARS Proteins
    Novus Biologicals CARS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CARS

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS11347887
    GO:0005829cytosol TAS--

    CARS for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CARS

    Protein Domains /
    Families
    for CARS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CARS for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR024909 Cys-tRNA/MSH_ligase
     IPR015803 Cys-tRNA-ligase
     IPR009080 tRNAsynth_1a_anticodon-bd
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry P49589

    ProtoNet protein and cluster: P49589

    1 Blocks protein family: IPB002308 Cysteinyl-tRNA synthetase signature

    UniProtKB/Swiss-Prot: SYCC_HUMAN, P49589
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    Function
    for CARS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYCC_HUMAN, P49589
    Catalytic activity: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

         Genatlas biochemistry entry for CARS:
    cysteinyl-tRNA synthetase,target autoantibodies in the immune disease polymyositis/dermatomyositis

         Enzyme Numbers (IUBMB): EC 6.1.1.161 2 EC 6.1.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding NAS7987009
    GO:0004817cysteine-tRNA ligase activity TAS--
    GO:0005515protein binding IPI10908348
    GO:0005524ATP binding IDA17303165
    GO:0042803protein homodimerization activity IMP17303165
         
    CARS for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CARS:
     Actin fiber cells  Synthetic lethal with gemcitab  Synthetic lethal with imatinib  Synthetic lethal with paclitax 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CARS 

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CARS:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmid: CARS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARS (see all 7)
    OriGene shRNA RFP: CARS
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CARS 

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for CARS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tRNA Aminoacylation
    		tRNA Aminoacylation1.00
    		Aminoacyl-tRNA biosynthesis0.54
    		Cytosolic tRNA aminoacylation0.57
    2Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for CARS
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression


    1         Kegg Pathway  (Kegg details for CARS):
        Aminoacyl-tRNA biosynthesis


    CARS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/24 Interacting proteins for CARS (P495893 ENSP000003698974) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCC1P187543, ENSP000003629374I2D: score=3 STRING: ENSP00000362937
    PACSIN3Q9UKS63, ENSP000002988384I2D: score=1 STRING: ENSP00000298838
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    PACSIN1Q9BY113, ENSP000002444584I2D: score=1 STRING: ENSP00000244458
    PACSIN2Q9UNF03, ENSP000002632464I2D: score=1 STRING: ENSP00000263246
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006423cysteinyl-tRNA aminoacylation IDA10908348
    GO:0010467gene expression TAS--

    CARS for ontologies           About GeneDecksing



    Drugs & Compounds
    for CARS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CARS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CARS

    1 HMDB Compound for CARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--

    1 DrugBank Compound for CARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Cysteine(R)-2-Amino-3-mercaptopropanoic acid (see all 13)52-90-4target--17139284 17016423

    10 Novoseek chemical compound relationships for CARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(cys) 86 8 16734420 (2), 10860750 (2), 17351629 (1)
    aminoacyl-trna 69.5 3 2014166 (2), 18285520 (1)
    trna 52.5 16 10860750 (3), 16734420 (2), 17303165 (1), 12810913 (1) (see all 5)
    anticodon 51.9 7 17303165 (2), 10860750 (1)
    calcium 48.7 22 14743430 (1), 15507543 (1), 20130845 (1), 19120320 (1) (see all 13)
    cysteine 38.3 5 16734420 (1), 11347887 (1), 15826650 (1), 17351629 (1)
    vitamin d 24.8 2 15507543 (1), 12771293 (1)
    phenylalanine 23.8 1 14660633 (1)
    nacl 0 1 9377470 (1)
    glutamate 0 4 14743430 (1), 9801147 (1), 12392104 (1)

    Search CenterWatch for drugs/clinical trials and news about CARS / SYCC 

    Transcripts
    for CARS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CARS gene (5 alternative transcripts): 
    NM_001014437.2  NM_001194997.1  NM_001751.5  NM_139273.3  NM_001014438.1  

    Unigene Cluster for CARS:

    Cysteinyl-tRNA synthetase
    Hs.274873  [show with all ESTs]
    Unigene Representative Sequence: NR_036542
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380525(uc010qxo.2 uc001lxf.3) ENST00000531387(uc001lxe.3)
    ENST00000397111(uc001lxg.3 uc001lxh.3) ENST00000484484 ENST00000278224
    ENST00000466442 ENST00000470221(uc009ydu.3) ENST00000526890 ENST00000529772
    ENST00000465240 ENST00000439280 ENST00000465207 ENST00000524825 ENST00000527330
    ENST00000465331 ENST00000397114 ENST00000401769(uc010qxp.2)

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CARS:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmid: CARS 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF288206.1 AF288207.1 AK093033.1 AK096313.1 AK222614.1 AK289432.1 AK295371.1 AK296763.1 
    AK298514.1 AK302644.1 AK308005.1 BC002880.2 BT009913.1 BX647906.1 L06845.1 NR_036542.1 

    24/30 DOTS entries (see all 30):

    DT.100796997  DT.456145  DT.100894880  DT.100797002  DT.91785902  DT.97807285  DT.102831796  DT.120685978 
    DT.100037028  DT.86854897  DT.100797006  DT.95364557  DT.80100194  DT.95217086  DT.99932771  DT.100796995 
    DT.100797001  DT.120686005  DT.70103600  DT.80100192  DT.95364561  DT.99994132  DT.120685966  DT.120685989 

    24/417 AceView cDNA sequences (see all 417):

    CN483268 AA134561 CA425722 BQ423314 AK096313 BQ941128 BE794238 AU126090 
    AI913515 BQ687621 AU125964 CA455097 AA364508 BM834777 AF288206 BI856359 
    BM979685 AW771631 CD743152 AI417460 BM917083 AI608729 CD557258 BE397017 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CARS (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                          -     -                       -                                               -     -                                             
    SP2:                    -     -     -           -           -                                               -     -                                             
    SP3:                    -     -     -           -           -                                               -     -                                             
    SP4:                          -     -           -           -                                                                                                   
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b
    SP1:                    -     -                             -           -               
    SP2:                    -     -                             -           -               
    SP3:                    -     -                             -                           
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CARS

    Expression
    for CARS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGTTCGTG
    CARS Expression
    About this image
    See CARS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CARS

    SOURCE GeneReport for Unigene cluster: Hs.274873
        SABiosciences Custom PCR Arrays for CARS

    Primer
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    In Situ
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    Orthologs
    for CARS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CARS gene from 10/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CARS1 cysteinyl-tRNA synthetase 75.54(n)
    82.3(a)    		   423086  NM_001012583.1  NP_001012601.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CARS6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 1(68593585-68628666)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cars-prov2 cysteinyl-tRNA synthetase 75.32(n)    BC046746.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.241922 Danio rerio, Similar to cysteinyl-tRNA synthetase, more 76.38(n)    BC048039.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BcDNA:LD211773
    Aats-cys1    		 cysteine-tRNA ligase3
    Cysteinyl-tRNA synthetase1    		 58(a)3
    61.42(n)1
    60.36(a)1    		   367841  NM_137243.21  NP_611087.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea crs-13
    cars-11    		 aminoacyl-tRNA synthetase3
    Protein CARS-11    		 53(a)3
    57.36(n)1
    56.11(a)1    		   I(2623361-2628578)3
    1718211  NM_058613.31  NP_491014.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes (YNL247W)4
    YNL247W1    		 Cysteinyl-tRNA synthetase; may interact with ribosomes, more4
    hypothetical protein1    		 51.79(n)1
    47.27(a)1    		   14(182875-185178)4
    8554741, 4  NP_014152.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G388306
    SYCO ARATH6
    (see all 3)    		 cysteinyl-tRNA synthetase
    (see all 3)    		 31(a)
    29(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 5(15545569-15548186)
    2(13282355-13285666)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 tRNA synthetase class I family protein, putative
    (see all 3)    		 31(a)
    29(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 3(2395735-2399591)
    10(16991986-16995373)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria cysS6
    		 cysteinyl-tRNA synthetase
    		 33(a)
    		 1 → many
    		 Chromosome(553834-555219) b0526


    ENSEMBL Gene Tree for CARS (if available)
    TreeFam Gene Tree for CARS (if available) 

    Paralogs
    for CARS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CARS gene
    CARS22  
    2 SIMAP similar genes for CARS using alignment to 7 protein entries:     SYCC_HUMAN (see all proteins):
    EEF1B2    DKFZp686G08243

    CARS for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CARS
    PGOHUM00000247154 PGOHUM00000249489


    Genomic Variants
    for CARS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1155 NCBI SNPs in CARS are shown (see all 1155)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1147878611,2
    		F--3021730(+) TGAGAC/TCACCC 5 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1996498211,2
    		--3021733(+) GACCA-/CCCC  
                CACAA     		5 -- ds50010--------
    rs118246131,2
    		C,F,H--3021803(+) AGCTCG/ACCAGG 5 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1887623241,2
    		--3022079(+) GTTGTG/TACCTG 5 -- ds50010--------
    rs1417293651,2
    		--3022095(+) CAAGCA/GGCCCT 5 -- ds50010--------
    rs618701631,2
    		C--3022102(+) NNNNGG/ACTGGC 5 -- ds50012Minor allele frequency- A:0.06NA 122
    rs1459864661,2
    		--3022113(+) CACCAC/GGCCTC 5 -- ds50010--------
    rs1142884951,2
    		F--3022121(+) CTCCTG/ACCAAG 5 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1927951421,2
    		--3022204(+) ACGACA/GACACG 5 -- nc-transcript-variantut310--------
    rs2009255431,2
    		--3022322(+) GGTTTA/CAAAAG 5 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for CARS (3022152 - 3078843 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CARS
         1 CNV: 31795
         1 Indel: 58511

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    Disorders / Diseases
    for CARS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CARS for disorders           About GeneDecksing

    OMIM gene information: 123859    OMIM disorders: --

    UniProtKB/Swiss-Prot: SYCC_HUMAN, P49589
  • Note=A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs).
    • Translocation t(2;11)(p23;p15) with ALK

    20/29 diseases for CARS (see all 29):    About MalaCards
    beckwith-wiedemann syndrome    adrenocortical carcinoma    wilms tumor    hypocalcemia, autosomal dominant
    rhabdomyosarcoma    breast cancer    anaplastic large cell lymphoma    hypocalcemia
    inflammatory myofibroblastic tumor    carcinoma    atypical autism    secondary hyperparathyroidism
    multiple system atrophy    intellectual disability    hypercalcemia    alcohol dependence
    hyperparathyroidism    hypoparathyroidism    polymyositis    dermatomyositis

    3 diseases from the University of Copenhagen DISEASES database for CARS:
    Autistic disorder     Atypical autism     Childhood disintegrative disease

    5 Novoseek disease relationships for CARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypocalcemia, autosomal dominant 78.6 1 9769711 (1)
    hyperparathyroidism secondary 48.2 1 12771293 (1)
    hypercalcemia 38.1 1 9769711 (1)
    renal failure chronic 16 1 12771293 (1)
    tumors 0 1 18566015 (1)

    Human Genome Epidemiology (HuGE) Navigator: CARS (11 documents)

    Export disorders for CARS gene to outside databases

    Publications
    for CARS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CARS gene, integrated from 9 sources (see all 100):
    (articles sorted by number of sources associating them with CARS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide and deduced amino acid sequence of human cysteinyl-tRNA synthetase. (PubMed id 7987009)1, 2, 9 Cruzen M.E. and Arfin S.M. (1994)
    2. Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase. (PubMed id 11347887)1, 2, 9 Davidson E.... King M.P. (2001)
    3. Assignment of the cysteinyl-tRNA synthetase gene (CARS) to 11p15.5. (PubMed id 8468064)1, 3, 9 Cruzen M.E....Arfin S.M. (1993)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. (PubMed id 12112524)1, 2 Cools J.... Marynen P. (2002)
    8. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. (PubMed id 19252134)1, 9 Pezzolesi M.G....Krolewski A.S. (2009)
    9. Kinetic quality control of anticodon recognition by a eukaryotic aminoacyl-tRNA synthetase. (PubMed id 17303165)1, 9 Liu C....Hou Y.M. (2007)
    10. An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing. (PubMed id 10908348)1, 9 Kim J.E....Kim S. (2000)

    External Searches for CARS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CARS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 833 HGNC: 1493 AceView: CARS Ensembl:ENSG00000110619 euGenes: HUgn833
    ECgene: CARS Kegg: 833 H-InvDB: CARS

    Other Databases showing CARS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CARS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CARS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CARS Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CARS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CARS gene:
    Search GeneIP for patents involving CARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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