Aliases for CARS Gene
External Ids for CARS Gene
Previous GeneCards Identifiers for CARS Gene
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
GeneCards Summary for CARS Gene
CARS (Cysteinyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with CARS include inflammatory myofibroblastic tumor and childhood disintegrative disease. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include protein homodimerization activity and cysteine-tRNA ligase activity. An important paralog of this gene is CARS2.