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CARS Gene

protein-coding   GIFtS: 67
GCID: GC11M003022

Cysteinyl-TRNA Synthetase

  See CARS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteinyl-TRNA Synthetase1 2 3     MGC:112462
EC 6.1.1.163 8     Cysteine Translase2
Cysteine TRNA Ligase 11     Cysteine TRNA Ligase 1, Cytoplasmic2
cytoplasmic1     Cysteine--TRNA Ligase, Cytoplasmic2
CARS12     CysRS3
CYSRS2     EC 6.1.18

External Ids:    HGNC: 14931   Entrez Gene: 8332   Ensembl: ENSG000001106197   OMIM: 1238595   UniProtKB: P495893   

Export aliases for CARS gene to outside databases

Previous GC identifers: GC11M003081 GC11M003272 GC11M002981 GC11M002986 GC11M002978 GC11M002810


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CARS Gene:
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty
aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the
cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an
important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann
syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers.
Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Aug 2010)

GeneCards Summary for CARS Gene:
CARS (cysteinyl-tRNA synthetase) is a protein-coding gene. Diseases associated with CARS include childhood disintegrative disease, and inflammatory myofibroblastic tumor. GO annotations related to this gene include cysteine-tRNA ligase activity and protein homodimerization activity. An important paralog of this gene is CARS2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NT_187585.1  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CARS gene promoter:
         RORalpha1   POU2F1   POU2F1a   Nkx2-5   Nkx5-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CARS promoter sequence
   Search Chromatin IP Primers for CARS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

CARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003022:  view genomic region     (about GC identifiers)

Start:
3,022,152 bp from pter      End:
3,078,843 bp from pter
Size:
56,692 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYCC_HUMAN, P49589 (See protein sequence)
Recommended Name: Cysteine--tRNA ligase, cytoplasmic  
Size: 748 amino acids; 85473 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Monomer (By similarity)
Sequence caution: Sequence=AAA73901.1; Type=Frameshift; Positions=619;
Secondary accessions: Q53XI8 Q5HYE4 Q9HD24 Q9HD25
Alternative splicing: 3 isoforms:  P49589-1   P49589-2   P49589-3   (Contains a phosphoserine at position 79)

Explore the universe of human proteins at neXtProt for CARS: NX_P49589

Explore proteomics data for CARS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CARS (P49589) (see all 21)
     QLRLAFL  DKIIKRA  DFALWKA  LHLYNSL 


    See CARS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001014437.1  NP_001181926.1  NP_001742.1  NP_644802.1  

    ENSEMBL proteins: 
     ENSP00000369897   ENSP00000431368   ENSP00000380300   ENSP00000278224   ENSP00000432619  
     ENSP00000408802   ENSP00000434184   ENSP00000380303   ENSP00000384069  
    Reactome Protein details: P49589

    CARS Human Recombinant Protein Products:

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    Novus Biologicals CARS Proteins
    Novus Biologicals CARS Lysates
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for CARS

     
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    CARS Antibody Products:

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    CARS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CARS
    Cloud-Clone Corp. CLIAs for CARS
    Search eBioscience for ELISAs for CARS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS1: Aminoacyl tRNA synthetases / Class I

    4 InterPro protein domains:
     IPR024909 Cys-tRNA/MSH_ligase
     IPR015803 Cys-tRNA-ligase
     IPR009080 tRNAsynth_1a_anticodon-bd
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry P49589

    ProtoNet protein and cluster: P49589

    1 Blocks protein domain: IPB002308 Cysteinyl-tRNA synthetase signature

    UniProtKB/Swiss-Prot: SYCC_HUMAN, P49589
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    Find genes that share domains with CARS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYCC_HUMAN, P49589
    Catalytic activity: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

         Genatlas biochemistry entry for CARS:
    cysteinyl-tRNA synthetase,target autoantibodies in the immune disease polymyositis/dermatomyositis

         Enzyme Numbers (IUBMB): EC 6.1.1.161 2 EC 6.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding NAS7987009
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004817cysteine-tRNA ligase activity TAS--
    GO:0005515protein binding IPI10908348
         
    Find genes that share ontologies with CARS           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CARS:
     Actin fiber cells  Synthetic lethal with gemcitab  Synthetic lethal with imatinib  Synthetic lethal with paclitax 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CARS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CARS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CARS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARS

    miRNA
    Products:
        
    miRTarBase miRNAs that target CARS:
    hsa-mir-30a-5p (MIRT049940), hsa-mir-652-3p (MIRT039547), hsa-mir-155-5p (MIRT020880), hsa-mir-92a-3p (MIRT049593)

    Block miRNA regulation of human, mouse, rat CARS using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CARS:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidCARS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CARS
    Predesigned siRNA for gene silencing in human, mouse, rat CARS

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CARS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CARS (NM_139273)
    Sino Biological Human cDNA Clone for CARS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARS

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CARS 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYCC_HUMAN, P49589: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    extracellular2
    chloroplast1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS11347887
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CARS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CARS About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with CARS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CARS
        Cytosolic tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for CARS):
        Aminoacyl-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CARS
    Interactions:

        Search GeneGlobe Interaction Network for CARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CARS (P495893 ENSP000003698974) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006423cysteinyl-tRNA aminoacylation IDA10908348
    GO:0010467gene expression TAS--

    Find genes that share ontologies with CARS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CARS (SYCC)

    1 HMDB Compound for CARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--

    1 DrugBank Compound for CARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Cysteine(R)-2-Amino-3-mercaptopropanoic acid (see all 13)52-90-4target--17139284 17016423

    10 Novoseek inferred chemical compound relationships for CARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(cys) 86 8 16734420 (2), 10860750 (2), 17351629 (1)
    aminoacyl-trna 69.5 3 2014166 (2), 18285520 (1)
    trna 52.5 16 10860750 (3), 16734420 (2), 17303165 (1), 12810913 (1) (see all 5)
    anticodon 51.9 7 17303165 (2), 10860750 (1)
    calcium 48.7 22 14743430 (1), 15507543 (1), 20130845 (1), 19120320 (1) (see all 13)
    cysteine 38.3 5 16734420 (1), 11347887 (1), 15826650 (1), 17351629 (1)
    vitamin d 24.8 2 15507543 (1), 12771293 (1)
    phenylalanine 23.8 1 14660633 (1)
    nacl 0 1 9377470 (1)
    glutamate 0 4 14743430 (1), 9801147 (1), 12392104 (1)



    Find genes that share compounds with CARS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CARS gene (5 alternative transcripts): 
    NM_001014437.2  NM_001194997.1  NM_001751.5  NM_139273.3  NM_001014438.1  

    Unigene Cluster for CARS:

    Cysteinyl-tRNA synthetase
    Hs.274873  [show with all ESTs]
    Unigene Representative Sequence: NR_036542
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380525(uc010qxo.2 uc001lxf.3) ENST00000531387(uc001lxe.3)
    ENST00000397111(uc001lxg.3 uc001lxh.3) ENST00000484484 ENST00000278224
    ENST00000466442 ENST00000470221(uc009ydu.3) ENST00000526890 ENST00000529772
    ENST00000465240 ENST00000439280 ENST00000465207 ENST00000524825 ENST00000527330
    ENST00000465331 ENST00000397114 ENST00000401769(uc010qxp.2)
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate CARS:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidCARS 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CARS
    Predesigned siRNA for gene silencing in human, mouse, rat CARS
    Clone
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    OriGene ORF clones in mouse, rat for CARS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CARS (NM_139273)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARS
    Primer
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    OriGene qPCR primer pairs and template standards for CARS
    OriGene qSTAR qPCR primer pairs in human, mouse for CARS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CARS
      QuantiTect SYBR Green Assays in human, mouse, rat CARS
      QuantiFast Probe-based Assays in human, mouse, rat CARS

    Additional mRNA sequence: 

    AF288206.1 AF288207.1 AK093033.1 AK096313.1 AK222614.1 AK289432.1 AK295371.1 AK296763.1 
    AK298514.1 AK302644.1 AK308005.1 BC002880.2 BT009913.1 BX647906.1 L06845.1 NR_036542.1 

    Selected DOTS entries (see all 30):

    DT.100796997  DT.456145  DT.100894880  DT.100797002  DT.91785902  DT.97807285  DT.102831796  DT.120685978 
    DT.100037028  DT.86854897  DT.100797006  DT.95364557  DT.80100194  DT.95217086  DT.99932771  DT.100796995 
    DT.100797001  DT.120686005  DT.70103600  DT.80100192  DT.95364561  DT.99994132  DT.120685966  DT.120685989 

    Selected AceView cDNA sequences (see all 417):

    AA480163 AI753042 CA455097 AI913515 AI051245 BE794238 AU126090 AA128044 
    AU125543 BM752321 AU125964 W73714 BG036009 BI856359 AK096313 BE254203 
    CB240733 BE730809 AA134561 AF288207 BQ069336 BC002880 AI086510 AU124780 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CARS (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                          -     -                       -                                               -     -                                             
    SP2:                    -     -     -           -           -                                               -     -                                             
    SP3:                    -     -     -           -           -                                               -     -                                             
    SP4:                          -     -           -           -                                                                                                   
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b
    SP1:                    -     -                             -           -               
    SP2:                    -     -                             -           -               
    SP3:                    -     -                             -                           
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGTTCGTG
    CARS Expression
    About this image


    CARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
    CARS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CARS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.274873
        Custom PCR Arrays for CARS
    Primer
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    OriGene qPCR primer pairs and template standards for CARS
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CARS gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cars1 , 5 cysteinyl-tRNA synthetase1, 5 86.08(n)1
    89.65(a)1
      7 (88.25 cM)5
    272671  NM_013742.51  NP_038770.31 
     1435572305 
    chicken
    (Gallus gallus)
    Aves CARS1 cysteinyl-tRNA synthetase 75.54(n)
    82.3(a)
      423086  NM_001012583.1  NP_001012601.1 
    lizard
    (Anolis carolinensis)
    Reptilia CARS6
    cysteinyl-tRNA synthetase
    77(a)
    1 ↔ 1
    1(68593585-68628666)
    African clawed frog
    (Xenopus laevis)
    Amphibia cars-prov2 cysteinyl-tRNA synthetase 75.32(n)    BC046746.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.241922 Danio rerio, Similar to cysteinyl-tRNA synthetase, more 76.38(n)    BC048039.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD211773
    Aats-cys1
    cysteine-tRNA ligase3
    Cysteinyl-tRNA synthetase1
    58(a)3
    61.5(n)1
    60.72(a)1
      367841  NM_137243.21  NP_611087.11 
    worm
    (Caenorhabditis elegans)
    Secernentea crs-13
    cars-11
    aminoacyl-tRNA synthetase3
    cars-11
    53(a)3
    56.93(n)1
    55.26(a)1
      I(2623361-2628578)3
    1718211  NM_058613.41  NP_491014.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YNL247W)4
    YNL247W1
    Cysteinyl-tRNA synthetase; may interact with ribosomes, more4
    YNL247W1
    51.67(n)1
    46.94(a)1
      14(182875-185178)4
    8554741, 4  NP_014152.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SYCO ARATH1 SYCO ARATH 47.79(n)
    40.85(a)
      817673  NM_128673.4  NP_565717.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g05565001 Os09g0556500 51.83(n)
    48.71(a)
      4347821  NM_001070434.1  NP_001063899.1 


    ENSEMBL Gene Tree for CARS (if available)
    TreeFam Gene Tree for CARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CARS gene
    CARS22  
    2 SIMAP similar genes for CARS using alignment to 7 protein entries:     SYCC_HUMAN (see all proteins):
    EEF1B2    DKFZp686G08243

    Find genes that share paralogs with CARS           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CARS
    PGOHUM00000247154 PGOHUM00000249489


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CARS (see all 1457)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1147878611,2
    F--3021730(+) TGAGAC/TCACCC 5 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1996498211,2
    C--3021733(+) AGACC-/CCCC  
            
    CCCCA
    5 -- ds50010--------
    rs118246131,2
    C,F,H--3021803(+) AGCTCG/ACCAGG 5 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1887623241,2
    --3022079(+) GTTGTG/TACCTG 5 -- ds50010--------
    rs1417293651,2
    C--3022095(+) CAAGCA/GGCCCT 5 -- ds50010--------
    rs618701631,2
    C--3022102(+) CCCTGG/ACTGGC 5 -- ds50012Minor allele frequency- A:0.06NA 122
    rs1459864661,2
    --3022113(+) CACCAC/GGCCTC 5 -- ds50010--------
    rs1142884951,2
    F--3022121(+) CTCCTG/ACCAAG 5 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1927951421,2
    --3022204(+) ACGACA/GACACG 5 -- ut31 nc-transcript-variant0--------
    rs2009255431,2
    --3022322(+) GGTTTA/CAAAAG 5 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for CARS (3022152 - 3078843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CARS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668116CNV Deletion23128226
    nsv819979CNV Loss19587683
    nsv8766CNV Loss18304495
    nsv825716CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CARS
    DNA2.0 Custom Variant and Variant Library Synthesis for CARS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123859    OMIM disorders: --

    UniProtKB/Swiss-Prot: SYCC_HUMAN, P49589
  • Note=A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors
    (IMTs). Translocation t(2;11)(p23;p15) with ALK

  • 6 diseases for CARS:    
    About MalaCards
    childhood disintegrative disease    inflammatory myofibroblastic tumor    hypocalcemia, autosomal dominant    atypical autism
    beckwith-wiedemann syndrome    wilms tumor

    3 diseases from the University of Copenhagen DISEASES database for CARS:
    Autistic disorder     Atypical autism     Childhood disintegrative disease

    Find genes that share disorders with CARS           About GenesLikeMe

    5 Novoseek inferred disease relationships for CARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypocalcemia, autosomal dominant 78.6 1 9769711 (1)
    hyperparathyroidism secondary 48.2 1 12771293 (1)
    hypercalcemia 38.1 1 9769711 (1)
    renal failure chronic 16 1 12771293 (1)
    tumors 0 1 18566015 (1)

    Genetic Association Database (GAD): CARS
    Human Genome Epidemiology (HuGE) Navigator: CARS (11 documents)

    Export disorders for CARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CARS gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with CARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. (PubMed id 19252134)1, 4, 9 Pezzolesi M.G....Krolewski A.S. (Diabetes 2009)
    2. Nucleotide and deduced amino acid sequence of human cysteinyl-tRNA synthetase. (PubMed id 7987009)1, 2, 9 Cruzen M.E. and Arfin S.M. (DNA Seq. 1994)
    3. Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase. (PubMed id 11347887)1, 2, 9 Davidson E.... King M.P. (Biol. Chem. 2001)
    4. Assignment of the cysteinyl-tRNA synthetase gene (CARS) to 11p15.5. (PubMed id 8468064)1, 3, 9 Cruzen M.E....Arfin S.M. (Genomics 1993)
    5. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. (PubMed id 20460425)1, 4 Maeda S....Nakamura Y. (Diabetes 2010)
    6. Joint influence of small-effect genetic variants on human longevity. (PubMed id 20834067)1, 4 Yashin A.I....Ukraintseva S.V. (Aging (Albany NY) 2010)
    7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. (PubMed id 12112524)1, 2 Cools J.... Marynen P. (Genes Chromosomes Cancer 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 833 HGNC: 1493 AceView: CARS Ensembl:ENSG00000110619 euGenes: HUgn833
    ECgene: CARS Kegg: 833 H-InvDB: CARS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CARS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CARS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CARS gene:
    Search GeneIP for patents involving CARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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