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Aliases for CARS Gene

Aliases for CARS Gene

  • Cysteinyl-TRNA Synthetase 4 2 3
  • EC 6.1.1.16 4 63
  • CysRS 3 4
  • Cysteine TRNA Ligase 1, Cytoplasmic 3
  • Cysteine--TRNA Ligase, Cytoplasmic 3
  • Cysteine TRNA Ligase 1 2
  • Cysteine Translase 3
  • Cytoplasmic 2
  • MGC:11246 3
  • EC 6.1.1 63
  • CARS1 3

External Ids for CARS Gene

Previous GeneCards Identifiers for CARS Gene

  • GC11M003081
  • GC11M003272
  • GC11M002981
  • GC11M002986
  • GC11M002978
  • GC11M002810

Summaries for CARS Gene

Entrez Gene Summary for CARS Gene

  • This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]

GeneCards Summary for CARS Gene

CARS (Cysteinyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with CARS include inflammatory myofibroblastic tumor and childhood disintegrative disease. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include protein homodimerization activity and cysteine-tRNA ligase activity. An important paralog of this gene is CARS2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARS Gene

Genomics for CARS Gene

Regulatory Elements for CARS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CARS Gene

Start:
3,000,922 bp from pter
End:
3,057,613 bp from pter
Size:
56,692 bases
Orientation:
Minus strand

Genomic View for CARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARS Gene

Proteins for CARS Gene

  • Protein details for CARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49589-SYCC_HUMAN
    Recommended name:
    Cysteine--tRNA ligase, cytoplasmic
    Protein Accession:
    P49589
    Secondary Accessions:
    • Q53XI8
    • Q5HYE4
    • Q9HD24
    • Q9HD25

    Protein attributes for CARS Gene

    Size:
    748 amino acids
    Molecular mass:
    85473 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAA73901.1; Type=Frameshift; Positions=619; Evidence={ECO:0000305};

    Alternative splice isoforms for CARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARS Gene

Proteomics data for CARS Gene at MOPED

Post-translational modifications for CARS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARS Gene

Antibody Products

Domains for CARS Gene

Gene Families for CARS Gene

HGNC:
  • aaRS1 :Aminoacyl tRNA synthetases / Class I

Graphical View of Domain Structure for InterPro Entry

P49589

UniProtKB/Swiss-Prot:

SYCC_HUMAN :
  • P49589
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with CARS: view

Function for CARS Gene

Molecular function for CARS Gene

GENATLAS Biochemistry: cysteinyl-tRNA synthetase,target autoantibodies in the immune disease polymyositis/dermatomyositis
UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

Enzyme Numbers (IUBMB) for CARS Gene

Gene Ontology (GO) - Molecular Function for CARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding NAS 7987009
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004817 cysteine-tRNA ligase activity TAS --
GO:0005515 protein binding IPI 10908348
genes like me logo Genes that share ontologies with CARS: view
genes like me logo Genes that share phenotypes with CARS: view

miRNA for CARS Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CARS Gene

Localization for CARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARS Gene COMPARTMENTS Subcellular localization image for CARS gene
Compartment Confidence
cytosol 4
cytoskeleton 2
extracellular 2
chloroplast 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11347887
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CARS: view

Pathways for CARS Gene

genes like me logo Genes that share pathways with CARS: view

Pathways by source for CARS Gene

1 KEGG pathway for CARS Gene

Gene Ontology (GO) - Biological Process for CARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006423 cysteinyl-tRNA aminoacylation IDA 10908348
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with CARS: view

Compounds for CARS Gene

(1) HMDB Compounds for CARS Gene

Compound Synonyms Cas Number PubMed IDs
L-Cysteine
  • (+)-2-Amino-3-mercaptopropionic acid
52-90-4

(1) Drugbank Compounds for CARS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Cysteine
  • (R)-2-Amino-3-mercaptopropanoic acid
52-90-4 target

(10) Novoseek inferred chemical compound relationships for CARS Gene

Compound -log(P) Hits PubMed IDs
trna(cys) 86 5
aminoacyl-trna 69.5 3
trna 52.5 8
anticodon 51.9 3
calcium 48.7 13
genes like me logo Genes that share compounds with CARS: view

Transcripts for CARS Gene

Unigene Clusters for CARS Gene

Cysteinyl-tRNA synthetase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CARS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5:
SP6: - - - -
SP7: - - -
SP8:
SP9: -
SP10:
SP11:
SP12:

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12: -

Relevant External Links for CARS Gene

GeneLoc Exon Structure for
CARS
ECgene alternative splicing isoforms for
CARS

Expression for CARS Gene

mRNA expression in normal human tissues for CARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARS Gene

SOURCE GeneReport for Unigene cluster for CARS Gene Hs.274873

genes like me logo Genes that share expressions with CARS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CARS Gene

Orthologs for CARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CARS 35
  • 99.56 (n)
  • 99.76 (a)
CARS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CARS 35
  • 81.22 (n)
  • 82.75 (a)
CARS 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARS 35
  • 85.44 (n)
  • 88.57 (a)
CARS 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cars 35
  • 86.08 (n)
  • 89.65 (a)
Cars 16
Cars 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CARS 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cars 35
  • 85.35 (n)
  • 89.62 (a)
chicken
(Gallus gallus)
Aves CARS 35
  • 75.54 (n)
  • 82.3 (a)
CARS 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CARS 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cars-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cars 35
  • 71.1 (n)
  • 76.93 (a)
zebrafish
(Danio rerio)
Actinopterygii cars 35
  • 68.98 (n)
  • 73.97 (a)
cars 36
  • 74 (a)
OneToOne
Dr.24192 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012283 35
  • 60.04 (n)
  • 60.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aats-cys 35
  • 61.5 (n)
  • 60.72 (a)
Aats-cys 36
  • 59 (a)
OneToOne
BcDNA:LD21177 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea cars-1 35
  • 56.93 (n)
  • 55.26 (a)
cars-1 36
  • 45 (a)
OneToOne
crs-1 37
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 44 (a)
OneToMany
-- 38
YNL247W 35
  • 51.67 (n)
  • 46.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03025g 35
  • 50.55 (n)
  • 47.23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SYCO ARATH 35
  • 47.79 (n)
  • 40.85 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2722 35
rice
(Oryza sativa)
Liliopsida Os09g0556500 35
  • 51.83 (n)
  • 48.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC29E6.06c 35
  • 50.7 (n)
  • 46.5 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14611 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7234 36
  • 59 (a)
OneToOne
Species with no ortholog for CARS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CARS Gene

ENSEMBL:
Gene Tree for CARS (if available)
TreeFam:
Gene Tree for CARS (if available)

Paralogs for CARS Gene

Paralogs for CARS Gene

Selected SIMAP similar genes for CARS Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CARS Gene

genes like me logo Genes that share paralogs with CARS: view

Variants for CARS Gene

Sequence variations from dbSNP and Humsavar for CARS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs80871 -- 3,028,613(+) GATGA(A/C)ATGCA intron-variant
rs80872 -- 3,028,754(+) TGGCT(G/T)CCGAG intron-variant
rs105686 -- 3,041,237(+) GGGAG(A/G)CGATA intron-variant
rs366422 -- 3,032,643(+) TTTTC(C/T)GATCT intron-variant
rs369461 -- 3,040,762(-) GAATC(A/G)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARS Gene

Variant ID Type Subtype PubMed ID
nsv8766 CNV Loss 18304495
nsv825716 CNV Gain 20364138
nsv819979 CNV Loss 19587683
esv2668116 CNV Deletion 23128226

Relevant External Links for CARS Gene

HapMap Linkage Disequilibrium report
CARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARS Gene

Disorders for CARS Gene

UniProtKB/Swiss-Prot

SYCC_HUMAN
  • Note=A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.

(3) University of Copenhagen DISEASES for CARS Gene

(5) Novoseek inferred disease relationships for CARS Gene

Disease -log(P) Hits PubMed IDs
hypocalcemia, autosomal dominant 78.6 1
hyperparathyroidism secondary 48.2 1
hypercalcemia 38.1 1
renal failure chronic 16 1
tumors 0 1

Relevant External Links for CARS

Genetic Association Database (GAD)
CARS
Human Genome Epidemiology (HuGE) Navigator
CARS
genes like me logo Genes that share disorders with CARS: view

Publications for CARS Gene

  1. Nucleotide and deduced amino acid sequence of human cysteinyl-tRNA synthetase. (PMID: 7987009) Cruzen M.E. … Arfin S.M. (DNA Seq. 1994) 3 4 23
  2. Assignment of the cysteinyl-tRNA synthetase gene (CARS) to 11p15.5. (PMID: 8468064) Cruzen M.E. … Arfin S.M. (Genomics 1993) 2 3 23
  3. Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase. (PMID: 11347887) Davidson E. … King M.P. (Biol. Chem. 2001) 3 4 23
  4. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. (PMID: 19252134) Pezzolesi M.G. … Krolewski A.S. (Diabetes 2009) 3 23 48
  5. An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing. (PMID: 10908348) Kim J.E. … Kim S. (Nucleic Acids Res. 2000) 3 23

Products for CARS Gene

Sources for CARS Gene

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