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CARNS1 Gene

protein-coding   GIFtS: 49
GCID: GC11P067183

Carnosine Synthase 1

(Previous name: ATP-grasp domain containing 1)
(Previous symbol: ATPGD1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carnosine Synthase 11 2
ATPGD11 2 3 5
ATP-Grasp Domain Containing 11 2
ATP-Grasp Domain-Containing Protein 12 3
KIAA13943 5
EC 6.3.2.113

External Ids:    HGNC: 292681   Entrez Gene: 575712   Ensembl: ENSG000001725087   OMIM: 6133685   UniProtKB: A5YM723   

Export aliases for CARNS1 gene to outside databases

Previous GC identifer: GC11P063511


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CARNS1 Gene:
CARNS1 (EC 6.3.2.11), a member of the ATP-grasp family of ATPases, catalyzes the formation of carnosine
(beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine), which are found mainly in skeletal
muscle and the central nervous system, respectively (Drozak et al., 2010 (PubMed 20097752)).(supplied by OMIM,
Apr 2010)

GeneCards Summary for CARNS1 Gene:
CARNS1 (carnosine synthase 1) is a protein-coding gene. GO annotations related to this gene include carnosine synthase activity and ATPase activity.

UniProtKB/Swiss-Prot: CRNS1_HUMAN, A5YM72
Function: Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than
homocarnosine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CARNS1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CARNS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARNS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

CARNS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARNS1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067183:  view genomic region     (about GC identifiers)

Start:
67,182,439 bp from pter      End:
67,193,078 bp from pter
Size:
10,640 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRNS1_HUMAN, A5YM72 (See protein sequence)
Recommended Name: Carnosine synthase 1  
Size: 827 amino acids; 88484 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Homotetramer (By similarity)
Sequence caution: Sequence=ABQ59056.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA92632.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K1M3 B4DFC6 E9PK38 Q8N467 Q9P2F3
Alternative splicing: 4 isoforms:  A5YM72-1   A5YM72-2   A5YM72-3   A5YM72-4   (No experimental confirmation available. Ref.3 (BAG57387) sequence is in conflict in positions: 2:L->F, 395:A->V)

Explore the universe of human proteins at neXtProt for CARNS1: NX_A5YM72

Explore proteomics data for CARNS1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CARNS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159694.1  NP_065862.1  

    ENSEMBL proteins: 
     ENSP00000431670   ENSP00000308268   ENSP00000389009   ENSP00000401519  

    CARNS1 Human Recombinant Protein Products:

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    Novus Biologicals CARNS1 Protein
    Novus Biologicals CARNS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CARNS1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011761 ATP-grasp
     IPR013816 ATP_grasp_subdomain_2

    Graphical View of Domain Structure for InterPro Entry A5YM72

    ProtoNet protein and cluster: A5YM72

    UniProtKB/Swiss-Prot: CRNS1_HUMAN, A5YM72
    Similarity: Contains 1 ATP-grasp domain


    Find genes that share domains with CARNS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRNS1_HUMAN, A5YM72
    Function: Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than
    homocarnosine
    Catalytic activity: ATP + L-histidine + beta-alanine = ADP + phosphate + carnosine
    Biophysicochemical properties: Kinetic parameters: KM=0.09 mM for beta-alanine; KM=1.84 mM for
    gamma-aminobutyrate; KM=0.37 mM for L-histidine; KM=4.67 mM for L-lysine; KM=7.66 mM for L-ornithine; KM=24.7 mM
    for N-methylhistidine; Vmax=65.3 nmol/min/mg enzyme toward beta-alanine; Vmax=54.7 nmol/min/mg enzyme toward
    gamma-aminobutyrate; Vmax=0.76 nmol/min/mg enzyme toward L-histidine; Vmax=0.61 nmol/min/mg enzyme toward
    L-lysine; Vmax=0.28 nmol/min/mg enzyme toward L-ornithine; Vmax=0.62 nmol/min/mg enzyme toward N-methylhistidine;

         Enzyme Number (IUBMB): EC 6.3.2.111

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IDA--
    GO:0046872metal ion binding IEA--
    GO:0047730carnosine synthase activity IDA--
         
    Find genes that share ontologies with CARNS1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CARNS1
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    miRNA
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    miRTarBase miRNAs that target CARNS1:
    hsa-mir-335-5p (MIRT019127)

    Block miRNA regulation of human, mouse, rat CARNS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CARNS1 (see all 12):
    hsa-miR-3146 hsa-miR-631 hsa-miR-449c* hsa-miR-346 hsa-miR-3661 hsa-miR-3926 hsa-miR-214 hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CARNS1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CARNS1 (NM_020811)
    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CARNS1

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with CARNS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CARNS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Histidine metabolism
    Histidine metabolism
    2beta-Alanine metabolism
    beta-Alanine metabolism
    3Arginine and proline metabolism
    Arginine and proline metabolism


    Find genes that share SuperPaths with CARNS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Kegg Pathways  (Kegg details for CARNS1):
        Arginine and proline metabolism
    Histidine metabolism
    beta-Alanine metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CARNS1
    Interactions:

        Search GeneGlobe Interaction Network for CARNS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CARNS1 (A5YM723 ENSP000003082684) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP12Q146693, ENSP000002839434I2D: score=3 STRING: ENSP00000283943
    CNDP1ENSP000003516824STRING: ENSP00000351682
    HEMK1ENSP000002328544STRING: ENSP00000232854
    ABATENSP000002682514STRING: ENSP00000268251
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA--
    GO:0035499carnosine biosynthetic process IDA--

    Find genes that share ontologies with CARNS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CARNS1 (CRNS1)

    1 HMDB Compound for CARNS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CARNS1 gene (2 alternative transcripts): 
    NM_001166222.1  NM_020811.1  

    Unigene Cluster for CARNS1:

    Carnosine synthase 1
    Hs.502982  [show with all ESTs]
    Unigene Representative Sequence: NM_001166222
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525907 ENST00000529925 ENST00000531040 ENST00000531958(uc010rpq.1)
    ENST00000307823(uc009yrp.3) ENST00000531388(uc001olc.4) ENST00000524740
    ENST00000445895 ENST00000423745(uc010rpr.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CARNS1 (see all 12):
    hsa-miR-3146 hsa-miR-631 hsa-miR-449c* hsa-miR-346 hsa-miR-3661 hsa-miR-3926 hsa-miR-214 hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CARNS1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CARNS1
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      QuantiFast Probe-based Assays in human, mouse, rat CARNS1

    Additional mRNA sequence: 

    AK289938.1 AK294035.1 AK295331.1 BC036557.1 EF560746.1 

    7 DOTS entries:

    DT.92059633  DT.108637  DT.120703579  DT.120703638  DT.120703613  DT.450687  DT.92465301 

    Selected AceView cDNA sequences (see all 364):

    BX375421 CR604258 BG030830 BC006106 AI807753 CR597985 BQ052262 AA372073 
    BE266524 AB037815 BU857251 BE832779 BU161951 BX538119 BQ924955 BX472608 
    CR618047 BQ431606 BI836595 CB991953 BU517144 BM829873 BM804913 CR605830 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CARNS1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                              -     -               
    SP2:                                                                                    
    SP3:                                                                                    


    ECgene alternative splicing isoforms for CARNS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CARNS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CARNS1 Expression
    About this image


    CARNS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Spinal Cord (Nervous System)
    CARNS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CARNS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502982
        Custom PCR Arrays for CARNS1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARNS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CARNS1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Carns11 , 5 carnosine synthase 11, 5 83.3(n)1
    83.93(a)1
      19 (3.86 cM)5
    1072391  NM_134148.21  NP_598909.21 
     41643245 
    chicken
    (Gallus gallus)
    Aves CARNS11 carnosine synthase 1 64.29(n)
    56.86(a)
      100359387  NM_001172593.1  NP_001166064.1 
    lizard
    (Anolis carolinensis)
    Reptilia CARNS16
    carnosine synthase 1
    57(a)
    1 ↔ 1
    1(93260639-93281137)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004879671 carnosine synthase 1-like 51.11(n)
    48.43(a)
      100487967  XM_004919211.1  XP_004919268.1 


    ENSEMBL Gene Tree for CARNS1 (if available)
    TreeFam Gene Tree for CARNS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CARNS1 (see all 283)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs722881741,2
    C--63509486(+) CTGAC-/ATGTGTG 2 -- us2k10--------
    rs118205361,2
    C,F,H--63509533(+) TCAAGG/TACAGC 2 -- us2k18Minor allele frequency- T:0.05NS NA WA 914
    rs1845925051,2
    --63509568(+) CGAGAC/TAGGCA 2 -- us2k10--------
    rs1423723901,2
    --63509807(+) GAGACC/TCAGGT 2 -- us2k10--------
    rs753341171,2
    C--67181165(+) ATGTCT/CTGGGG 2 -- us2k14Minor allele frequency- C:0.07CSA WA NA EA 359
    rs1459616361,2
    --67181178(+) ATTATA/GGCTTC 2 -- us2k10--------
    rs1386154101,2
    C--67181406(+) CCCCGC/TCTCCA 2 -- us2k10--------
    rs1889906441,2
    --67181452(+) CGGTAC/GCTCAT 2 -- us2k10--------
    rs766417891,2
    C--67181463(+) GCCTGA/TAATCC 2 -- us2k10--------
    rs776320511,2
    C--67181476(+) ATACTC/TTGGGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CARNS1 (67182439 - 67193078 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CARNS1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468604CNV Loss19166990
    nsv516453CNV Loss19592680
    nsv897796CNV Loss21882294
    dgv1195n71CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv521723CNV Loss19592680
    nsv897811CNV Loss21882294
    nsv524096CNV Loss19592680
    dgv1194n71CNV Loss21882294
    dgv1193n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CARNS1
    DNA2.0 Custom Variant and Variant Library Synthesis for CARNS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613368    OMIM disorders: --


    Find genes that share disorders with CARNS1           About GenesLikeMe


    Export disorders for CARNS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CARNS1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CARNS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of carnosine synthase as ATP-grasp domain- containing protein 1 (ATPGD1). (PubMed id 20097752)1, 2, 3 Drozak J....Van Schaftingen E. (J. Biol. Chem. 2010)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. (PubMed id 12421765)1 Nakayama M.... Ohara O. (Genome Res. 2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57571 HGNC: 29268 AceView: RPS6KB2andKIAA1394 Ensembl:ENSG00000172508 euGenes: HUgn57571
    ECgene: CARNS1 Kegg: 57571 H-InvDB: CARNS1

    (According to HUGE)
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    HUGE: KIAA1394

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CARNS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CARNS1 gene:
    Search GeneIP for patents involving CARNS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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