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Aliases for CARMN Gene

Subcategory (RNA class) for CARMN Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for CARMN Gene

  • Cardiac Mesoderm Enhancer-Associated Non-Coding RNA 2 3 5
  • MIR143 Host Gene (Non-Protein Coding) 2 3
  • Cardiac Mesoderm Enhancer-Associated Noncoding RNA 3
  • MIR143 And MIR145 Host Gene 2
  • MIR143 And MIR145 Host 3
  • MIR143 Host Gene 2
  • MIR143HG 3
  • CARMEN 3

External Ids for CARMN Gene

Previous HGNC Symbols for CARMN Gene

  • MIR143HG

Summaries for CARMN Gene

GeneCards Summary for CARMN Gene

CARMN (Cardiac Mesoderm Enhancer-Associated Non-Coding RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CARMN include Hirschsprung Disease 1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARMN Gene

Genomics for CARMN Gene

Regulatory Elements for CARMN Gene

Enhancers for CARMN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G149935 2.1 FANTOM5 Ensembl ENCODE dbSUPER 16.6 +534.6 534646 12.4 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 SLC26A2 CARMN HMGXB3 ZNF300 RBM22 PPARGC1B CSNK1A1 CD74 ENSG00000200334 GC05M149941
GH05G149495 2.2 Ensembl ENCODE dbSUPER 10.3 +90.6 90588 4.1 ZNF362 CEBPG ZNF664 ZNF316 POLR2A ZNF512 SCRT2 FOS KDM1A EMSY ARHGEF37 MIR145 RPL29P14 CSNK1A1 MIR143 RNU6-588P CARMN IL17B PCYOX1L ENSG00000230551
GH05G149438 1.9 VISTA Ensembl ENCODE dbSUPER 11.4 +36.7 36714 10.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B PCYOX1L IL17B CARMN TIGD6 ARHGEF37 PDGFRB MIR145 ENSG00000230551
GH05G149319 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -84.1 -84091 6.6 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 PCYOX1L HMGXB3 GRPEL2 ENSG00000253865 GRPEL2-AS1 MIR145 AFAP1L1 MIR143 CARMN IL17B
GH05G149481 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +79.9 79911 9.6 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF416 FOS PAF1 ARHGEF37 HMGXB3 TIGD6 MIR145 RPL29P14 CSNK1A1 CARMN IL17B MIR143 RNU6-588P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CARMN on UCSC Golden Path with GeneCards custom track

Promoters for CARMN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000188796 1611 3000 BCOR USF2 ZMYM3 ZNF398 NR2F2 RAD51 JUND GATA2 POLR2A GLIS1

Genomic Location for CARMN Gene

Chromosome:
5
Start:
149,406,689 bp from pter
End:
149,432,836 bp from pter
Size:
26,148 bases
Orientation:
Plus strand

Genomic View for CARMN Gene

Genes around CARMN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARMN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARMN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARMN Gene

Proteins for CARMN Gene

Post-translational modifications for CARMN Gene

No Post-translational modifications

No data available for DME Specific Peptides for CARMN Gene

Domains & Families for CARMN Gene

Gene Families for CARMN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CARMN: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CARMN Gene

Function for CARMN Gene

Phenotypes for CARMN Gene

GenomeRNAi human phenotypes for CARMN:
genes like me logo Genes that share phenotypes with CARMN: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CARMN Gene

Localization for CARMN Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CARMN Gene

Pathways & Interactions for CARMN Gene

SuperPathways for CARMN Gene

No Data Available

Interacting Proteins for CARMN Gene

Gene Ontology (GO) - Biological Process for CARMN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CARMN Gene

Drugs & Compounds for CARMN Gene

No Compound Related Data Available

Transcripts for CARMN Gene

mRNA/cDNA for CARMN Gene

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CARMN Gene

No ASD Table

Relevant External Links for CARMN Gene

GeneLoc Exon Structure for
CARMN
ECgene alternative splicing isoforms for
CARMN

Expression for CARMN Gene

NURSA nuclear receptor signaling pathways regulating expression of CARMN Gene:

CARMN
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARMN Gene

Orthologs for CARMN Gene

Evolution for CARMN Gene

ENSEMBL:
Gene Tree for CARMN (if available)
TreeFam:
Gene Tree for CARMN (if available)

No data available for Orthologs for CARMN Gene

Paralogs for CARMN Gene

No data available for Paralogs for CARMN Gene

Variants for CARMN Gene

Sequence variations from dbSNP and Humsavar for CARMN Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000039678 -- 149,412,492(+) AGGCC(A/G)GGTGC intron-variant
rs1000085959 -- 149,411,348(+) GGGTT(G/T)GAATC intron-variant
rs1000223068 -- 149,425,491(+) CCAAA(A/C)TCAGT intron-variant
rs1000275419 -- 149,425,800(+) GTAAA(C/T)AGGAC intron-variant
rs1000579512 -- 149,415,313(+) CTGGC(C/G)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARMN Gene

Variant ID Type Subtype PubMed ID
esv2668220 CNV deletion 23128226
nsv516607 CNV loss 19592680
nsv519878 CNV loss 19592680
nsv521406 CNV loss 19592680
nsv528923 CNV loss 19592680
nsv599948 CNV loss 21841781

Relevant External Links for CARMN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARMN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CARMN Gene

Disorders for CARMN Gene

MalaCards: The human disease database

(1) MalaCards diseases for CARMN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hirschsprung disease 1
  • hirschsprung's disease
- elite association - COSMIC cancer census association via MalaCards
Search CARMN in MalaCards View complete list of genes associated with diseases

Relevant External Links for CARMN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARMN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARMN
genes like me logo Genes that share disorders with CARMN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CARMN Gene

Publications for CARMN Gene

  1. Negative feedback circuitry between MIR143HG and RBM24 in Hirschsprung disease. (PMID: 27565737) Du C. … Xia Y. (Biochim. Biophys. Acta 2016) 2 3 64
  2. CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis. (PMID: 26423156) Ounzain S. … Pedrazzini T. (J. Mol. Cell. Cardiol. 2015) 2 3 64
  3. miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. (PMID: 19730444) Spizzo R. … Calin G.A. (Cell Death Differ. 2010) 3 64
  4. Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. (PMID: 21159816) Kent O.A. … Mendell J.T. (Genes Dev. 2010) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for CARMN Gene

Sources for CARMN Gene

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