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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARM1 Gene

protein-coding   GIFtS: 63
GCID: GC19P010982

coactivator-associated arginine methyltransferase 1
 Explore 19 diseases affiliated with
CARM1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CARM1    

Aliases
for CARM1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Coactivator-Associated Arginine Methyltransferase 11 2 3     EC 2.1.1.-3
PRMT41 2 3     EC 2.1.1.1253
Protein Arginine N-Methyltransferase 42 3     EC 2.1.18
Histone-Arginine Methyltransferase CARM12     

External Ids:    HGNC: 233931   Entrez Gene: 104982   Ensembl: ENSG000001424537   OMIM: 6039345   UniProtKB: Q86X553   

Export aliases for CARM1 gene to outside databases

Previous GC identifers: GC19P011113 GC19P010827 GC19P010843 GC19P010560


Summaries
for CARM1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CARM1:
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from
S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine
derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction,
metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 (PubMed 11724789)).(supplied by
OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
Function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several
proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to
promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates
histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate
transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts
synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and
NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together
with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as
a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation
of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing
factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142',
which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its
interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in
RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of
their target mRNAs




Genomic Views
for CARM1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARM1 gene promoter:
         GR   CREB   PPAR-gamma1   GR-beta   deltaCREB   GR-alpha   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CARM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CARM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

CARM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARM1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010982:  view genomic region     (about GC identifiers)

Start:
 10,982,189 bp from pter      End:
 11,033,453 bp from pter
Size:
 51,265 bases      Orientation:
 plus strand

Proteins
for CARM1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55 (See protein sequence)
Recommended Name: Histone-arginine methyltransferase CARM1  
Size: 608 amino acids; 65854 Da
Subunit: Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a
complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300,
TRIM24, CREBBP and CTNNB1. Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1. Interacts with
NCOA3/SRC3. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA. Interacts with HTLV-1
Tax-1
Subcellular location: Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle.
Cytoplasmic during mitosis, after breakup of the nuclear membrane
3 PDB 3D structures from and Proteopedia for CARM1:
2Y1W (3D)        2Y1X (3D)        4IKP (3D)    
Secondary accessions: A6NN38
Alternative splicing: 3 isoforms:  Q86X55-3   Q86X55-1   Q86X55-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CARM1: NX_Q86X55

Post-translational modifications:

  • Auto-methylated on Arg-550. Methylation enhances transcription coactivator activity. Methylation is required for its
    • role in the regulation of pre-mRNA alternative splicing (By similarity)1
  • Phosphorylation at Ser-216 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase
    • activity (By similarity). Phosphorylation at Ser-216 is strongly increased during mitosis, and decreases rapidly to a
    very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-216 may promote location
    in the cytosol1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86X55

    • 3 DME Specific Peptides for CARM1 (Q86X55)
     GCGSGIL  VLDVGCG  DKIVLDVG 

    CARM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_954592.1  
    ENSEMBL proteins: 
     ENSP00000325690   ENSP00000465417   ENSP00000467420   ENSP00000340934   ENSP00000467746  
     ENSP00000464852   ENSP00000468319   ENSP00000467761  
    Reactome Protein details: Q86X55
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CARM1 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CARM1
    OriGene Purified Protein: CARM1
    OriGene Protein Over-expression Lysate: CARM1
    OriGene Custom Protein Services for CARM1 
    GenScript Custom Purified and Recombinant Proteins Services for CARM1
    Novus Biologicals CARM1 Protein
    Novus Biologicals CARM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CARM1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15221992
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA15221992
    GO:0005829cytosol ISS--


    CARM1 for ontologies           About GeneDecksing



    CARM1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CARM1
    R&D Systems Antibodies for CARM1
    Cell Signaling Technology (CST) Antibodies for CARM1 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CARM1 
    GenScript Superior Antibodies for CARM1
    Novus Biologicals CARM1 Antibodies
    Search for Antibodies for CARM1 at Abcam  
    Uscn Antibodies for CARM1
    ThermoFisher Antibody for CARM1

    Assay Products for CARM1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CARM1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CARM1

    Protein Domains /
    Families
    for CARM1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CARM1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR025797 Arg_MeTrfase_CARM1
     IPR025799 Arg_MeTrfase
     IPR020989 Histone-Arg_MeTrfase_N

    Graphical View of Domain Structure for InterPro Entry Q86X55

    ProtoNet protein and cluster: Q86X55

    UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
    Similarity: Belongs to the protein arginine N-methyltransferase family


    Function
    for CARM1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
    Function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several
    proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to
    promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates
    histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate
    transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts
    synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and
    NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together
    with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as
    a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation
    of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing
    factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142',
    which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its
    interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in
    RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of
    their target mRNAs
    Catalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine +
    N(omega)-methyl-arginine-[histone]
    Enzyme regulation: Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 'Lys-18' (H3K18ac) H3
    'Lys-23' (H3K23ac) by EP300 and blocked by citrullination of H3 'Arg-17' (H3R17ci) by PADI4 (By similarity)

    Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.1251

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CARM1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARM1
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CARM1 (see all 41):
    hsa-miR-579 hsa-miR-15a hsa-miR-9 hsa-miR-424 hsa-miR-15b hsa-miR-626 hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: CARM1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARM1 (see all 7)
    OriGene shRNA RFP: CARM1
    OriGene siRNA: CARM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARM1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CARM1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARM1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARM1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CARM1 (NM_199141)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARM1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CARM1
    Search LifeMap BioReagents cell lines for CARM1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARM1

    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding ----
    GO:0008013beta-catenin binding TAS16344550
    GO:0008276protein methyltransferase activity ISS--
    GO:0016274protein-arginine N-methyltransferase activity ISS--


    CARM1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CARM1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Carm1tm1Mtb for CARM1
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Carm1):
     adipose tissue  cellular  growth/size  hematopoietic system  immune system 
     mortality/aging  respiratory system 

    CARM1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CARM1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response_Function of MEF2 in T lymphocytes
    		Immune response_Function of MEF2 in T lymphocytes1.00
    		Immune response Function of MEF2 in T lymphocytes0.90
    2Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    4Cell cycle ESR1 regulation of G1/S transition
    		Cell cycle ESR1 regulation of G1/S transition1.00
    		Cell cycle_ESR1 regulation of G1/S transition0.97
    5Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    		Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis1.00
    		Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis0.97

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for CARM1 (see all 6)
        Immune response Function of MEF2 in T lymphocytes
    Histone modification
    Cell cycle ESR1 regulation of G1/S transition
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-dependent activation of the ESR1/SP pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CARM1
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    1 Cell Signaling Technology (CST) Pathway for CARM1
        Chromatin Regulation / Acetylation

    5 GeneGo (Thomson Reuters) Pathways for CARM1
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Cell cycle ESR1 regulation of G1/S transition
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Function of MEF2 in T lymphocytes

    4 BioSystems Pathways for CARM1 
        Androgen receptor signaling pathway
    Direct p53 effectors
    Regulation of Androgen receptor activity
    Coregulation of Androgen receptor activity

    4        Reactome Pathways for CARM1
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    Metabolism of lipids and lipoproteins



    CARM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CARM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/200 Interacting proteins for CARM1 (Q86X552, 3 ENSP000003256904) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003420regulation of growth plate cartilage chondrocyte proliferation IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ISS--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0009405pathogenesis IEA--


    CARM1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CARM1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CARM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CARM1

    2 HMDB Compounds for CARM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    8 Novoseek chemical compound relationships for CARM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 83.3 150 16497732 (3), 11341840 (3), 18280497 (3), 11050077 (2) (see all 59)
    estrogen 51.1 18 18172323 (5), 11010967 (2), 17640894 (2), 20360387 (1) (see all 6)
    s-adenosylmethionine 47.8 4 10381882 (1), 19843527 (1), 17640894 (1)
    steroid 45.1 15 19183483 (1), 14500758 (1), 15731352 (1), 18048071 (1) (see all 8)
    retinoid 40.5 4 15731352 (1), 15525597 (1)
    cyclic amp 4.11 3 15525597 (1), 16254053 (1)
    testosterone 0 12 16705743 (4), 16492776 (1)
    creatinine 0 1 11713257 (1)

    Search CenterWatch for drugs/clinical trials and news about CARM1 

    Transcripts
    for CARM1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CARM1 gene: 
    NM_199141.1  

    Unigene Cluster for CARM1:

    Coactivator-associated arginine methyltransferase 1
    Hs.323213  [show with all ESTs]
    Unigene Representative Sequence: NM_199141
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327064(uc002mpz.3 uc010dxn.3) ENST00000588947 ENST00000590699
    ENST00000344150(uc002mqa.3) ENST00000586221 ENST00000590039 ENST00000589693
    ENST00000586508 ENST00000586298 ENST00000592516

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CARM1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARM1
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CARM1 (see all 41):
    hsa-miR-579 hsa-miR-15a hsa-miR-9 hsa-miR-424 hsa-miR-15b hsa-miR-626 hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: CARM1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARM1 (see all 7)
    OriGene shRNA RFP: CARM1
    OriGene siRNA: CARM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARM1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARM1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARM1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CARM1 (NM_199141)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARM1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARM1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CARM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARM1

    Additional cDNA sequence: 

    AF055027.1 AL833242.1 BC036886.1 BC046240.1 BC070496.1 

    19 DOTS entries:

    DT.100661719  DT.100883379  DT.97775761  DT.85104699  DT.100883380  DT.100883374  DT.100709504  DT.97855195 
    DT.97855194  DT.220742  DT.100681577  DT.100686557  DT.121457088  DT.75155444  DT.75182575  DT.91765876 
    DT.97802100  DT.100883383  DT.95270450 

    24/311 AceView cDNA sequences (see all 311):

    BM910450 BM564727 BI916315 BE336679 AI475510 BI258584 BQ064125 AI559647 
    AF055027 CA430644 BU845053 CA841001 BU623703 BQ015200 AI300464 BU844475 
    AI564530 AA810120 CA308620 AI523077 BU552954 BQ923382 AI913922 AA316660 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CARM1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                                                                -           -                                                               
    SP2:                                                                                -           -     -                                                         
    SP3:                                                                                -           -     -                                                         
    SP4:                                                                                -           -     -                                                         
    SP5:                                                                                -           -     -                                                         

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CARM1

    Expression
    for CARM1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CARM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCTTTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CARM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Inner Cell MassInner Cell MassInner Cell Mass CellsEarly Embryo
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CARM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CARM1

    SOURCE GeneReport for Unigene cluster: Hs.323213

    UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
    Tissue specificity: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia

        SABiosciences Expression via Pathway-Focused PCR Array including CARM1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CARM1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CARM1 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia CARM16
    		 --
    		 94(a)
    		 1 ↔ 1
    		 2(80849536-80876217)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.96442 Xenopus laevis transcribed sequence with weak similarity more 80.83(n)    CA787702.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii btg12 B-cell translocation gene 1 76.55(n)    BM530251.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG53583
    Art41    		 protein-arginine N-methyltransferase3
    Arginine methyltransferase 41    		 59(a)
    (best of 2)3
    60.64(n)1
    60.41(a)1    		   85F43
    412191  NM_141706.21  NP_649963.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PRMT4B1 histone-arginine methyltransferase CARM1 54.48(n)
    52.34(a)    		   819878  NM_180197.2  NP_850528.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.107782 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 67.94(n)    AK065980.1 


    ENSEMBL Gene Tree for CARM1 (if available)
    TreeFam Gene Tree for CARM1 (if available) 

    Paralogs
    for CARM1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CARM1 gene
    PRMT62  PRMT32  PRMT22  PRMT12  PRMT82  
    4 SIMAP similar genes for CARM1 using alignment to 7 protein entries:     CARM1_HUMAN (see all proteins):
    PRMT1    PRMT2    PRMT8    PRMT6

    CARM1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CARM1
    PGOHUM00000250487


    Genomic Variants
    for CARM1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/775 NCBI SNPs in CARM1 are shown (see all 775)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs18616341,2
    		C,F,A,H,--10980353(+) ACACCC/TGTGGA 2 -- us2k1 ut3110Minor allele frequency- T:0.04MN NS EA NA WA 1382
    rs743418111,2
    		C,F,--10980566(+) TTTGAA/GGCATC 2 -- us2k1 ds50011Minor allele frequency- G:0.03WA 118
    rs1927565501,2
    		--10980599(+) GTATGC/TGGAGC 2 -- us2k1 ds50010--------
    rs1162690711,2
    		--10980604(+) CGGAGC/TCTCCT 2 -- us2k1 ds50011Minor allele frequency- T:0.01WA 118
    rs735006311,2
    		C,--10980655(+) GCAACG/CGTACT 2 -- ds5001 us2k11Minor allele frequency- C:0.50WA 2
    rs1852307581,2
    		--10980793(+) CTTGAA/GCCCAG 2 -- ds5001 us2k10--------
    rs1892392571,2
    		--10980825(+) TATGAC/TGGCAC 2 -- ds5001 us2k10--------
    rs1819226271,2
    		--10980901(+) GTGGCC/TCATGC 1 -- us2k10--------
    rs1847403701,2
    		--10980929(+) TGGGAG/TGCCGA 1 -- us2k10--------
    rs1895049251,2
    		--10980956(+) GAAGTC/TAGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CARM1 (10982189 - 11033453 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CARM1
         1 CNV: 5087

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    Disorders / Diseases
    for CARM1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CARM1 for disorders           About GeneDecksing

    OMIM gene information: 603934    OMIM disorders: --

    19 diseases for CARM1:    About MalaCards
    homocysteine    spinal muscular atrophy    spina bifida    muscular atrophy
    sporadic breast cancer    breast cancer    prostate cancer    rhabdomyosarcoma
    prostatitis    prostate adenocarcinoma    colon cancer    prostate carcinoma
    colorectal cancer    adenocarcinoma    cholesterol    thyroiditis
    carcinoma    malaria    neuronitis

    4 Novoseek disease relationships for CARM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 14.4 9 18172323 (4), 19183483 (1), 15525597 (1), 16938873 (1)
    necrosis 0 3 19769987 (1)
    tumors 0 6 16938873 (1), 18461904 (1), 19769987 (1)
    prostate cancer 0 4 16705743 (4)

    Human Genome Epidemiology (HuGE) Navigator: CARM1 (5 documents)

    Export disorders for CARM1 gene to outside databases

    Publications
    for CARM1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CARM1 gene, integrated from 9 sources (see all 131):
    (articles sorted by number of sources associating them with CARM1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status. (PubMed id 15221992)1, 2, 9 Hong H.... Cheng L. (2004)
    2. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PubMed id 16497732)1, 2, 9 Miao F.... Natarajan R. (2006)
    3. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. (PubMed id 15471871)1, 2, 9 Ananthanarayanan M....Walsh M.J. (2004)
    4. Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax. (PubMed id 17005681)1, 2, 9 Jeong S.J.... Brady J.N. (2006)
    5. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. (PubMed id 12237300)1, 2, 9 Li H.... Laird-Offringa I.A. (2002)
    6. Regulation of transcription by a protein methyltransferase. (PubMed id 10381882)1, 3, 9 Chen D....Stallcup M.R. (1999)
    7. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. (PubMed id 15731352)1, 2, 9 Lee Y.-H.... Stallcup M.R. (2005)
    8. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. (PubMed id 11724789)1, 3, 9 Frankel A....Bedford M.T. (2002)
    9. Kinetic analysis of human protein arginine N-methyltr ansferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PubMed id 19405910)1, 2 Lakowski T.M. and Frankel A. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for CARM1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CARM1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10498 HGNC: 23393 AceView: CARM1 Ensembl:ENSG00000142453 euGenes: HUgn10498
    ECgene: CARM1 H-InvDB: CARM1

    Other Databases showing CARM1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CARM1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CARM1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CARM1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CARM1 gene:
    Search GeneIP for patents involving CARM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CARM1 gene

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    About This Section

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