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Aliases for CARM1 Gene

Aliases for CARM1 Gene

  • Coactivator Associated Arginine Methyltransferase 1 2 3 5
  • Coactivator-Associated Arginine Methyltransferase 1 3 4
  • Protein Arginine N-Methyltransferase 4 3 4
  • PRMT4 3 4
  • EC 2.1.1.319 4
  • EC 2.1.1 63

External Ids for CARM1 Gene

Previous GeneCards Identifiers for CARM1 Gene

  • GC19P011113
  • GC19P010827
  • GC19P010843
  • GC19P010982
  • GC19P010560

Summaries for CARM1 Gene

Entrez Gene Summary for CARM1 Gene

  • This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

GeneCards Summary for CARM1 Gene

CARM1 (Coactivator Associated Arginine Methyltransferase 1) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot for CARM1 Gene

  • Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at Arg-17 (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at Arg-2142, which may loosen its interaction with NCOA2/GRIP1, and at Arg-580 and Arg-604 in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARM1 Gene

Genomics for CARM1 Gene

Regulatory Elements for CARM1 Gene

Enhancers for CARM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CARM1 on UCSC Golden Path with GeneCards custom track

Promoters for CARM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CARM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CARM1 Gene

Chromosome:
19
Start:
10,871,513 bp from pter
End:
10,923,070 bp from pter
Size:
51,558 bases
Orientation:
Plus strand

Genomic View for CARM1 Gene

Genes around CARM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARM1 Gene

Proteins for CARM1 Gene

  • Protein details for CARM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X55-CARM1_HUMAN
    Recommended name:
    Histone-arginine methyltransferase CARM1
    Protein Accession:
    Q86X55
    Secondary Accessions:
    • A6NN38

    Protein attributes for CARM1 Gene

    Size:
    608 amino acids
    Molecular mass:
    65854 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, TRIM24, CREBBP and CTNNB1. Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1. Interacts with NCOA3/SRC3. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA. Interacts with HTLV-1 Tax-1.

    Three dimensional structures from OCA and Proteopedia for CARM1 Gene

    Alternative splice isoforms for CARM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARM1 Gene

Proteomics data for CARM1 Gene at MOPED

Selected DME Specific Peptides for CARM1 Gene

Post-translational modifications for CARM1 Gene

  • Auto-methylated on Arg-550. Methylation enhances transcription coactivator activity. Methylation is required for its role in the regulation of pre-mRNA alternative splicing (By similarity).
  • Phosphorylation at Ser-216 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase activity (By similarity). Phosphorylation at Ser-216 is strongly increased during mitosis, and decreases rapidly to a very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-216 may promote location in the cytosol.
  • Ubiquitination at Lys 227 and Lys 470
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CARM1 (CARM1)

Domains & Families for CARM1 Gene

Gene Families for CARM1 Gene

Protein Domains for CARM1 Gene

Suggested Antigen Peptide Sequences for CARM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86X55

UniProtKB/Swiss-Prot:

CARM1_HUMAN :
  • Contains 1 SAM-dependent MTase PRMT-type domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Domain:
  • Contains 1 SAM-dependent MTase PRMT-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with CARM1: view

Function for CARM1 Gene

Molecular function for CARM1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 Lys-18 (H3K18ac) H3 Lys-23 (H3K23ac) by EP300 and blocked by citrullination of H3 Arg-17 (H3R17ci) by PADI4.
UniProtKB/Swiss-Prot Function:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at Arg-17 (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at Arg-2142, which may loosen its interaction with NCOA2/GRIP1, and at Arg-580 and Arg-604 in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.

Enzyme Numbers (IUBMB) for CARM1 Gene

Gene Ontology (GO) - Molecular Function for CARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016274 protein-arginine N-methyltransferase activity ISS,TAS --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity ISS --
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity ISS --
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with CARM1: view
genes like me logo Genes that share phenotypes with CARM1: view

Animal Models for CARM1 Gene

MGI Knock Outs for CARM1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CARM1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARM1 Gene

Localization for CARM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARM1 Gene

Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARM1 Gene COMPARTMENTS Subcellular localization image for CARM1 gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for CARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090575 RNA polymerase II transcription factor complex IEA --
genes like me logo Genes that share ontologies with CARM1: view

Pathways & Interactions for CARM1 Gene

genes like me logo Genes that share pathways with CARM1: view

SIGNOR curated interactions for CARM1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation IEA --
GO:0007568 aging IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0016032 viral process IEA --
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA --
genes like me logo Genes that share ontologies with CARM1: view

Drugs & Compounds for CARM1 Gene

(8) Drugs for CARM1 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
BMS PYRAZOLE INHIBITOR 7F Pharma 0
COMPOUND 17F [PMID:19632837] Pharma 0

(3) Additional Compounds for CARM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CARM1: view

Transcripts for CARM1 Gene

Unigene Clusters for CARM1 Gene

Coactivator-associated arginine methyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7:
SP8: - -
SP9: -

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CARM1 Gene

GeneLoc Exon Structure for
CARM1
ECgene alternative splicing isoforms for
CARM1

Expression for CARM1 Gene

mRNA expression in normal human tissues for CARM1 Gene

mRNA differential expression in normal tissues according to GTEx for CARM1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for CARM1 Gene

This gene is overexpressed in Breast (10.3) and Uterus (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARM1 Gene



SOURCE GeneReport for Unigene cluster for CARM1 Gene Hs.323213

mRNA Expression by UniProt/SwissProt for CARM1 Gene

Q86X55-CARM1_HUMAN
Tissue specificity: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
genes like me logo Genes that share expression patterns with CARM1: view

Protein tissue co-expression partners for CARM1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CARM1 Gene

Orthologs for CARM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CARM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CARM1 35
  • 91.05 (n)
  • 97.06 (a)
CARM1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARM1 35
  • 93.57 (n)
  • 98.69 (a)
CARM1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Carm1 35
  • 90.51 (n)
  • 97.6 (a)
Carm1 16
Carm1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Carm1 35
  • 91.14 (n)
  • 97.6 (a)
oppossum
(Monodelphis domestica)
Mammalia CARM1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CARM1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CARM1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CARM1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia carm1 35
  • 77.89 (n)
  • 87.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9644 35
zebrafish
(Danio rerio)
Actinopterygii btg1 35
carm1 35
  • 77.14 (n)
  • 86.18 (a)
carm1 36
  • 85 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16840 37
  • 37 (a)
CG5358 37
  • 59 (a)
Art4 35
  • 60.64 (n)
  • 60.41 (a)
Art4 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta CARM1_ANOGA 35
  • 64.43 (n)
  • 63.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 36
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PRMT4B 35
  • 52.93 (n)
  • 48.74 (a)
rice
(Oryza sativa)
Liliopsida Os.10778 35
Os07g0671700 35
  • 53.45 (n)
  • 52.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2441 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5717 36
  • 60 (a)
OneToOne
Species with no ortholog for CARM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARM1 Gene

ENSEMBL:
Gene Tree for CARM1 (if available)
TreeFam:
Gene Tree for CARM1 (if available)

Paralogs for CARM1 Gene

Paralogs for CARM1 Gene

(4) SIMAP similar genes for CARM1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CARM1 Gene

genes like me logo Genes that share paralogs with CARM1: view

Variants for CARM1 Gene

Sequence variations from dbSNP and Humsavar for CARM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256879 -- 10,874,686(+) cgcac(C/T)GCCCT intron-variant
rs7257708 -- 10,905,095(+) CTTCC(A/C)TTCCG intron-variant
rs7258596 -- 10,902,024(+) agagc(A/G)cttga intron-variant
rs7258995 -- 10,902,352(+) ACAGT(A/G)GTGTG intron-variant
rs7259138 -- 10,877,307(+) ACCAG(A/T)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARM1 Gene

Variant ID Type Subtype PubMed ID
nsv833748 CNV Loss 17160897
nsv911050 CNV Loss 21882294
nsv833749 CNV Loss 17160897
nsv911051 CNV Loss 21882294

Variation tolerance for CARM1 Gene

Residual Variation Intolerance Score: 8.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARM1 Gene

Human Gene Mutation Database (HGMD)
CARM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARM1 Gene

Disorders for CARM1 Gene

Relevant External Links for CARM1

Genetic Association Database (GAD)
CARM1
Human Genome Epidemiology (HuGE) Navigator
CARM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARM1

No disorders were found for CARM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARM1 Gene

Publications for CARM1 Gene

  1. Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status. (PMID: 15221992) Hong H. … Cheng L. (Cancer 2004) 3 4 23 67
  2. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. (PMID: 11724789) Frankel A. … Bedford M.T. (J. Biol. Chem. 2002) 2 3 23
  3. Regulation of transcription by a protein methyltransferase. (PMID: 10381882) Chen D. … Stallcup M.R. (Science 1999) 2 3 23
  4. Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17. (PMID: 20022955) Selvi B.R. … Kundu T.K. (J. Biol. Chem. 2010) 3 23
  5. CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cells. (PMID: 20213728) Gao X. … Shen Y.F. (J. Cell. Biochem. 2010) 3 23

Products for CARM1 Gene

Sources for CARM1 Gene

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