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Aliases for CARM1 Gene

Aliases for CARM1 Gene

  • Coactivator-Associated Arginine Methyltransferase 1 2 3 4
  • PRMT4 3 4 6
  • Protein Arginine N-Methyltransferase 4 3 4
  • Histone-Arginine Methyltransferase CARM1 3
  • EC 2.1.1.125 4
  • EC 2.1.1.- 4
  • EC 2.1.1 63

External Ids for CARM1 Gene

Previous GeneCards Identifiers for CARM1 Gene

  • GC19P011113
  • GC19P010827
  • GC19P010843
  • GC19P010982
  • GC19P010560

Summaries for CARM1 Gene

Entrez Gene Summary for CARM1 Gene

  • This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

GeneCards Summary for CARM1 Gene

CARM1 (Coactivator-Associated Arginine Methyltransferase 1) is a Protein Coding gene. Diseases associated with CARM1 include breast cancer. Among its related pathways are L1CAM interactions and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot for CARM1 Gene

  • Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at Arg-17 (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at Arg-2142, which may loosen its interaction with NCOA2/GRIP1, and at Arg-580 and Arg-604 in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARM1 Gene

Genomics for CARM1 Gene

Regulatory Elements for CARM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CARM1 Gene

Start:
10,871,513 bp from pter
End:
10,923,070 bp from pter
Size:
51,558 bases
Orientation:
Plus strand

Genomic View for CARM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARM1 Gene

Proteins for CARM1 Gene

  • Protein details for CARM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X55-CARM1_HUMAN
    Recommended name:
    Histone-arginine methyltransferase CARM1
    Protein Accession:
    Q86X55
    Secondary Accessions:
    • A6NN38

    Protein attributes for CARM1 Gene

    Size:
    608 amino acids
    Molecular mass:
    65854 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, TRIM24, CREBBP and CTNNB1. Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1. Interacts with NCOA3/SRC3. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA. Interacts with HTLV-1 Tax-1.

    Three dimensional structures from OCA and Proteopedia for CARM1 Gene

    Alternative splice isoforms for CARM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARM1 Gene

Proteomics data for CARM1 Gene at MOPED

Selected DME Specific Peptides for CARM1 Gene

Post-translational modifications for CARM1 Gene

  • Auto-methylated on Arg-550. Methylation enhances transcription coactivator activity. Methylation is required for its role in the regulation of pre-mRNA alternative splicing (By similarity).
  • Phosphorylation at Ser-216 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase activity (By similarity). Phosphorylation at Ser-216 is strongly increased during mitosis, and decreases rapidly to a very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-216 may promote location in the cytosol.
  • Ubiquitination at Lys227 and Lys470
  • Modification sites at PhosphoSitePlus

Other Protein References for CARM1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CARM1 (CARM1)

Domains for CARM1 Gene

Gene Families for CARM1 Gene

HGNC:
  • PRMT :Protein arginine methyltransferases
IUPHAR :

Protein Domains for CARM1 Gene

Suggested Antigen Peptide Sequences for CARM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86X55

UniProtKB/Swiss-Prot:

CARM1_HUMAN :
  • Q86X55
Domain:
  • Contains 1 SAM-dependent MTase PRMT-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with CARM1: view

Function for CARM1 Gene

Molecular function for CARM1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
UniProtKB/Swiss-Prot EnzymeRegulation: Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 Lys-18 (H3K18ac) H3 Lys-23 (H3K23ac) by EP300 and blocked by citrullination of H3 Arg-17 (H3R17ci) by PADI4.
UniProtKB/Swiss-Prot Function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at Arg-17 (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at Arg-2142, which may loosen its interaction with NCOA2/GRIP1, and at Arg-580 and Arg-604 in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.

Enzyme Numbers (IUBMB) for CARM1 Gene

Gene Ontology (GO) - Molecular Function for CARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS --
GO:0005515 protein binding IPI 20111005
GO:0008013 beta-catenin binding TAS 16344550
GO:0008168 methyltransferase activity --
GO:0008276 protein methyltransferase activity ISS --
genes like me logo Genes that share ontologies with CARM1: view
genes like me logo Genes that share phenotypes with CARM1: view

Animal Models for CARM1 Gene

MGI Knock Outs for CARM1:

Animal Model Products

CRISPR Products

miRNA for CARM1 Gene

miRTarBase miRNAs that target CARM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CARM1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CARM1 Gene

Localization for CARM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARM1 Gene

Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARM1 Gene COMPARTMENTS Subcellular localization image for CARM1 gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for CARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15221992
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with CARM1: view

Pathways for CARM1 Gene

genes like me logo Genes that share pathways with CARM1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat

Gene Ontology (GO) - Biological Process for CARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006479 protein methylation --
genes like me logo Genes that share ontologies with CARM1: view

Compounds for CARM1 Gene

(2) HMDB Compounds for CARM1 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(8) Novoseek inferred chemical compound relationships for CARM1 Gene

Compound -log(P) Hits PubMed IDs
arginine 83.3 89
estrogen 51.1 12
s-adenosylmethionine 47.8 3
steroid 45.1 8
retinoid 40.5 2
genes like me logo Genes that share compounds with CARM1: view

Transcripts for CARM1 Gene

Unigene Clusters for CARM1 Gene

Coactivator-associated arginine methyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CARM1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CARM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7:
SP8: - -
SP9: -

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CARM1 Gene

GeneLoc Exon Structure for
CARM1
ECgene alternative splicing isoforms for
CARM1

Expression for CARM1 Gene

mRNA expression in normal human tissues for CARM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CARM1 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARM1 Gene

SOURCE GeneReport for Unigene cluster for CARM1 Gene Hs.323213

mRNA Expression by UniProt/SwissProt for CARM1 Gene

Q86X55-CARM1_HUMAN
Tissue specificity: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
genes like me logo Genes that share expressions with CARM1: view

In Situ Assay Products

Orthologs for CARM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CARM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CARM1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CARM1 35
  • 91.05 (n)
  • 97.06 (a)
CARM1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARM1 35
  • 93.57 (n)
  • 98.69 (a)
CARM1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Carm1 35
  • 90.51 (n)
  • 97.6 (a)
Carm1 16
Carm1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CARM1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CARM1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Carm1 35
  • 91.14 (n)
  • 97.6 (a)
lizard
(Anolis carolinensis)
Reptilia CARM1 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9644 35
tropical clawed frog
(Silurana tropicalis)
Amphibia carm1 35
  • 77.89 (n)
  • 87.33 (a)
zebrafish
(Danio rerio)
Actinopterygii btg1 35
carm1 35
  • 77.14 (n)
  • 86.18 (a)
carm1 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta CARM1_ANOGA 35
  • 64.43 (n)
  • 63.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta Art4 35
  • 60.64 (n)
  • 60.41 (a)
Art4 36
  • 54 (a)
OneToOne
CG5358 37
  • 59 (a)
CG16840 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 36
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PRMT4B 35
  • 52.93 (n)
  • 48.74 (a)
rice
(Oryza sativa)
Liliopsida Os.10778 35
Os07g0671700 35
  • 53.45 (n)
  • 52.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2441 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5717 36
  • 60 (a)
OneToOne
Species with no ortholog for CARM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARM1 Gene

ENSEMBL:
Gene Tree for CARM1 (if available)
TreeFam:
Gene Tree for CARM1 (if available)

Paralogs for CARM1 Gene

Paralogs for CARM1 Gene

Selected SIMAP similar genes for CARM1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CARM1 Gene

genes like me logo Genes that share paralogs with CARM1: view

Variants for CARM1 Gene

Sequence variations from dbSNP and Humsavar for CARM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs892011 -- 10,907,727(+) GGGCC(A/G)GTGGG intron-variant
rs1056212 -- 10,914,010(+) GCGCA(A/T)CTGGA frameshift-variant, reference
rs1123488 -- 10,892,685(+) GAATC(C/T)TCACT intron-variant
rs1529711 -- 10,912,758(-) TCCAC(A/G)ACCCC intron-variant
rs1541595 -- 10,876,233(+) tttgc(C/T)caggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARM1 Gene

Variant ID Type Subtype PubMed ID
nsv833748 CNV Loss 17160897
nsv911050 CNV Loss 21882294
nsv833749 CNV Loss 17160897
nsv911051 CNV Loss 21882294

Relevant External Links for CARM1 Gene

HapMap Linkage Disequilibrium report
CARM1
Human Gene Mutation Database (HGMD)
CARM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARM1 Gene

Disorders for CARM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CARM1 Gene including...

Search for CARM1 Gene in MalaCards »

(4) Novoseek inferred disease relationships for CARM1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 14.4 7
necrosis 0 1
tumors 0 3
prostate cancer 0 4

Relevant External Links for CARM1

Genetic Association Database (GAD)
CARM1
Human Genome Epidemiology (HuGE) Navigator
CARM1
genes like me logo Genes that share disorders with CARM1: view

No data available for UniProtKB/Swiss-Prot for CARM1 Gene

Publications for CARM1 Gene

  1. Regulation of transcription by a protein methyltransferase. (PMID: 10381882) Chen D. … Stallcup M.R. (Science 1999) 2 3 23
  2. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. (PMID: 11724789) Frankel A. … Bedford M.T. (J. Biol. Chem. 2002) 2 3 23
  3. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. (PMID: 12237300) Li H. … Laird-Offringa I.A. (J. Biol. Chem. 2002) 3 4 23
  4. Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status. (PMID: 15221992) Hong H. … Cheng L. (Cancer 2004) 3 4 23
  5. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. (PMID: 15471871) Ananthanarayanan M. … Walsh M.J. (J. Biol. Chem. 2004) 3 4 23

Products for CARM1 Gene

Sources for CARM1 Gene

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