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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARM1 Gene

protein-coding   GIFtS: 65
GCID: GC19P010982

Coactivator-Associated Arginine Methyltransferase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coactivator-Associated Arginine Methyltransferase 11 2 3     EC 2.1.1.-3
Protein Arginine N-Methyltransferase 42 3     EC 2.1.1.1253
PRMT42 3     EC 2.1.18
Histone-Arginine Methyltransferase CARM12     

External Ids:    HGNC: 233931   Entrez Gene: 104982   Ensembl: ENSG000001424537   OMIM: 6039345   UniProtKB: Q86X553   

Export aliases for CARM1 gene to outside databases

Previous GC identifers: GC19P011113 GC19P010827 GC19P010843 GC19P010560


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CARM1 Gene:
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the
methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and
other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in
association with other proteins or within multi-protein complexes and may play a role in cell type-specific
functions and cell lineage specification. A related pseudogene is located on chromosome 9. (provided by RefSeq,
Aug 2013)

GeneCards Summary for CARM1 Gene: 
CARM1 (coactivator-associated arginine methyltransferase 1) is a protein-coding gene. Diseases associated with CARM1 include sporadic breast cancer, and spina bifida, and among its related super-pathways are Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolic pathways. GO annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
Function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several
proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to
promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families,
methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to
activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4
activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1,
NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional
activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation,
acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte
differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative
splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation.
Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580'
and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent
transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4,
which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARM1 gene promoter:
         GR   CREB   PPAR-gamma1   GR-beta   deltaCREB   GR-alpha   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCARM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CARM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

CARM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARM1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010982:  view genomic region     (about GC identifiers)

Start:
10,982,189 bp from pter      End:
11,033,453 bp from pter
Size:
51,265 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55 (See protein sequence)
Recommended Name: Histone-arginine methyltransferase CARM1  
Size: 608 amino acids; 65854 Da
Subunit: Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a
complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2,
EP300/P300, TRIM24, CREBBP and CTNNB1. Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1.
Interacts with NCOA3/SRC3. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA.
Interacts with HTLV-1 Tax-1
Subcellular location: Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle.
Cytoplasmic during mitosis, after breakup of the nuclear membrane
3 PDB 3D structures from and Proteopedia for CARM1:
2Y1W (3D)        2Y1X (3D)        4IKP (3D)    
Secondary accessions: A6NN38
Alternative splicing: 3 isoforms:  Q86X55-3   Q86X55-1   Q86X55-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CARM1: NX_Q86X55

Explore proteomics data for CARM1 at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-methylated on Arg-550. Methylation enhances transcription coactivator activity. Methylation is required for
    its role in the regulation of pre-mRNA alternative splicing (By similarity)
  • UniProtKB: Phosphorylation at Ser-216 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase
    activity (By similarity). Phosphorylation at Ser-216 is strongly increased during mitosis, and decreases rapidly
    to a very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-216 may
    promote location in the cytosol
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86X55

  • 3 DME Specific Peptides for CARM1 (Q86X55)
     GCGSGIL  VLDVGCG  DKIVLDVG 

    CARM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CARM1 Protein Expression
    REFSEQ proteins: NP_954592.1  
    ENSEMBL proteins: 
     ENSP00000325690   ENSP00000465417   ENSP00000467420   ENSP00000340934   ENSP00000467746  
     ENSP00000464852   ENSP00000468319   ENSP00000467761  
    Reactome Protein details: Q86X55
    Human Recombinant Protein Products for CARM1: 
    EMD Millipore Purified and/or Recombinant CARM1 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CARM1
    OriGene Purified Protein for CARM1
    OriGene Protein Over-expression Lysate for CARM1
    OriGene MassSpec for CARM1 
    OriGene Custom Protein Services for CARM1
    GenScript Custom Purified and Recombinant Proteins Services for CARM1
    Novus Biologicals CARM1 Protein
    Novus Biologicals CARM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CARM1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15221992
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA15221992
    GO:0005829cytosol ISS--

    CARM1 for ontologies           About GeneDecksing



    CARM1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CARM1
    R&D Systems Antibodies for CARM1
    Cell Signaling Technology (CST) Antibodies for CARM1 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CARM1
    GenScript Superior Antibodies for CARM1
    Novus Biologicals CARM1 Antibodies
    Abcam antibodies for CARM1
    Cloud-Clone Corp. Antibodies for CARM1 
    ThermoFisher Antibody for CARM1
    LSBio Antibodies in human, mouse, rat for CARM1 

    Assay Products for CARM1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CARM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CARM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CARM1 
    Cloud-Clone Corp. CLIAs for CARM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT4 
    Protein arginine N-methyltransferases

    3 InterPro protein domains:
     IPR025797 Arg_MeTrfase_CARM1
     IPR025799 Arg_MeTrfase
     IPR020989 Histone-Arg_MeTrfase_N

    Graphical View of Domain Structure for InterPro Entry Q86X55

    ProtoNet protein and cluster: Q86X55

    UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
    Similarity: Belongs to the protein arginine N-methyltransferase family


    CARM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CARM1_HUMAN, Q86X55
    Function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several
    proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to
    promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families,
    methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to
    activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4
    activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1,
    NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional
    activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation,
    acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte
    differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative
    splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation.
    Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580'
    and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent
    transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4,
    which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs
    Catalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine +
    N(omega)-methyl-arginine-[histone]
    Enzyme regulation: Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 'Lys-18'
    (H3K18ac) H3 'Lys-23' (H3K23ac) by EP300 and blocked by citrullination of H3 'Arg-17' (H3R17ci) by PADI4 (By
    similarity)

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.1251

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding IPI--
    GO:0008013beta-catenin binding TAS16344550
    GO:0008168methyltransferase activity ----
    GO:0008276protein methyltransferase activity ISS--
         
    CARM1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CARM1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Carm1):
     adipose tissue  cellular  growth/size  hematopoietic system  immune system 
     mortality/aging  respiratory system 

    CARM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Carm1tm1Mtb for CARM1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CARM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CARM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CARM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARM1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARM1
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CARM1 (see all 41):
    hsa-miR-579 hsa-miR-15a hsa-miR-9 hsa-miR-424 hsa-miR-15b hsa-miR-626 hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCARM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CARM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CARM1
    Sirion Biotech Customized adenovirus for overexpression of CARM1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CARM1 (see all 8)
    OriGene ORF clones in mouse, rat for CARM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CARM1 (NM_199141)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARM1
    Sirion Biotech Customized lentivirus for stable overexpression of CARM1 
                         Customized lentivirus expression plasmids for stable overexpression of CARM1 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CARM1 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3Immune response Function of MEF2 in T lymphocytes
    Immune response Function of MEF2 in T lymphocytes0.90
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis0.38
    4Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    5Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for CARM1 (see all 6)
        Immune response Function of MEF2 in T lymphocytes
    Histone modification
    Cell cycle ESR1 regulation of G1/S transition
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-dependent activation of the ESR1/SP pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CARM1
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    1 Cell Signaling Technology (CST) Pathway for CARM1
        Chromatin Regulation / Acetylation

    5 GeneGo (Thomson Reuters) Pathways for CARM1
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Cell cycle ESR1 regulation of G1/S transition
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Function of MEF2 in T lymphocytes

    4 BioSystems Pathways for CARM1
        Androgen receptor signaling pathway
    Regulation of Androgen receptor activity
    Coregulation of Androgen receptor activity
    Direct p53 effectors

    4        Reactome Pathways for CARM1
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    Metabolism of lipids and lipoproteins



    CARM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CARM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/200 Interacting proteins for CARM1 (Q86X552, 3 ENSP000003256904) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003420regulation of growth plate cartilage chondrocyte proliferation IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ISS--
    GO:0006479protein methylation ----
    GO:0008152metabolic process ----

    CARM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CARM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CARM1

    2 HMDB Compounds for CARM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    8 Novoseek inferred chemical compound relationships for CARM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 83.3 150 16497732 (3), 11341840 (3), 18280497 (3), 11050077 (2) (see all 59)
    estrogen 51.1 18 18172323 (5), 11010967 (2), 17640894 (2), 20360387 (1) (see all 6)
    s-adenosylmethionine 47.8 4 10381882 (1), 19843527 (1), 17640894 (1)
    steroid 45.1 15 19183483 (1), 14500758 (1), 15731352 (1), 18048071 (1) (see all 8)
    retinoid 40.5 4 15731352 (1), 15525597 (1)
    cyclic amp 4.11 3 15525597 (1), 16254053 (1)
    testosterone 0 12 16705743 (4), 16492776 (1)
    creatinine 0 1 11713257 (1)

    Search CenterWatch for drugs/clinical trials and news about CARM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CARM1 gene: 
    NM_199141.1  

    Unigene Cluster for CARM1:

    Coactivator-associated arginine methyltransferase 1
    Hs.323213  [show with all ESTs]
    Unigene Representative Sequence: NM_199141
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327064(uc002mpz.3 uc010dxn.3) ENST00000588947 ENST00000590699
    ENST00000344150(uc002mqa.3) ENST00000586221 ENST00000590039 ENST00000589693
    ENST00000586508 ENST00000586298 ENST00000592516
    miRNA
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    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CARM1 (see all 41):
    hsa-miR-579 hsa-miR-15a hsa-miR-9 hsa-miR-424 hsa-miR-15b hsa-miR-626 hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCARM1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARM1
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    OriGene clones in human, mouse for CARM1 (see all 8)
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    GenScript: all cDNA clones in your preferred vector: CARM1 (NM_199141)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARM1
    Sirion Biotech Customized lentivirus for stable overexpression of CARM1 
                         Customized lentivirus expression plasmids for stable overexpression of CARM1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CARM1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CARM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARM1

    Additional mRNA sequence: 

    AF055027.1 AL833242.1 BC036886.1 BC046240.1 BC070496.1 

    18 DOTS entries:

    DT.100661719  DT.97775761  DT.100883379  DT.85104699  DT.100883374  DT.100883380  DT.97855195  DT.97855194 
    DT.100709504  DT.220742  DT.121457088  DT.75155444  DT.75182575  DT.97802100  DT.100681577  DT.100686557 
    DT.100883383  DT.95270450 

    24/311 AceView cDNA sequences (see all 311):

    CR604934 BU956694 BQ015200 AI300464 BM743234 AA810120 AI200775 AI342852 
    BI258584 AI523077 CD370742 BI870524 BQ278927 BE501369 AI890554 BQ962620 
    AI084885 BU552954 BQ218262 AL135354 BQ653901 AI524632 AI601222 F36282 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CARM1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                                                                -           -                                                               
    SP2:                                                                                -           -     -                                                         
    SP3:                                                                                -           -     -                                                         
    SP4:                                                                                -           -     -                                                         
    SP5:                                                                                -           -     -                                                         

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CARM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CARM1 expression in normal human tissues (normalized intensities)      CARM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTTTTTT
    CARM1 Expression
    About this image


    CARM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             brain/midbrain   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, pre-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             reticulocytes   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See CARM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CARM1

    SOURCE GeneReport for Unigene cluster: Hs.323213

    UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
    Tissue specificity: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia

        SABiosciences Expression via Pathway-Focused PCR Array including CARM1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CARM1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Carm11 , 5 coactivator-associated arginine methyltransferase 11, 5 91.09(n)1
    98.18(a)1
      9 (7.82 cM)5
    590351  NM_021531.61  NP_067506.21 
     215468945 
    lizard
    (Anolis carolinensis)
    Reptilia CARM16
    Uncharacterized protein
    95(a)
    1 ↔ 1
    2(80849536-80876217)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.96442 Xenopus laevis transcribed sequence with weak similarity more 80.83(n)    CA787702.1 
    zebrafish
    (Danio rerio)
    Actinopterygii btg12 B-cell translocation gene 1 76.55(n)    BM530251.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53583
    Art41
    protein-arginine N-methyltransferase3
    Arginine methyltransferase 41
    59(a)
    (best of 2)3
    60.64(n)1
    60.41(a)1
      85F43
    412191  NM_141706.21  NP_649963.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HMT16
    Nuclear SAM-dependent mono- and asymmetric arginin...
    33(a)
    1 → many
    II(304930-305976)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PRMT4B1 histone-arginine methyltransferase CARM1 54.48(n)
    52.34(a)
      819878  NM_180197.2  NP_850528.1 
    rice
    (Oryza sativa)
    Liliopsida Os.107782 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 67.94(n)    AK065980.1 


    ENSEMBL Gene Tree for CARM1 (if available)
    TreeFam Gene Tree for CARM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CARM1 gene
    PRMT62  PRMT32  PRMT22  PRMT12  PRMT82  
    4 SIMAP similar genes for CARM1 using alignment to 7 protein entries:     CARM1_HUMAN (see all proteins):
    PRMT1    PRMT2    PRMT8    PRMT6

    CARM1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CARM1
    PGOHUM00000250487


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1036 SNPs in CARM1 are shown (see all 1036)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819226271,2
    --10980901(+) GTGGCC/TCATGC 1 -- us2k10--------
    rs1847403701,2
    --10980929(+) TGGGAG/TGCCGA 1 -- us2k10--------
    rs1895049251,2
    --10980956(+) GAAGTC/TAGGAG 1 -- us2k10--------
    rs124604211,2
    C,F,H--10981352(+) GGGCCA/GGGCTG 1 -- us2k124Minor allele frequency- G:0.48NS EA NA WA CSA 2704
    rs1395568231,2
    --10981633(+) GCCCAA/TTCCCC 1 -- us2k10--------
    rs1497308841,2
    C--10981811(+) AAGCCG/TCATCA 1 -- us2k10--------
    rs1175698511,2
    C,F--10981992(+) CGACGT/CACCCT 1 -- us2k12Minor allele frequency- C:0.39NA EA 240
    rs1124388921,2
    C--10982190(+) GGCGAA/GGCGGC 1 -- us2k10--------
    rs1489567311,2
    --10983286(+) AGCCTC/TCTCCC 1 -- int10--------
    rs1470239791,2
    --10983331(+) TTTTCC/TGAAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CARM1 (10982189 - 11033453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CARM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911050CNV Loss21882294
    nsv911051CNV Loss21882294
    nsv833749CNV Loss17160897
    nsv833748CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603934    OMIM disorders: --

    16 diseases for CARM1:    About MalaCards
    sporadic breast cancer    spina bifida    spinal muscular atrophy    muscular atrophy
    prostate adenocarcinoma    rhabdomyosarcoma    prostatitis    breast cancer
    kaposi's sarcoma    prostate cancer    colon cancer    adenocarcinoma
    colorectal cancer    sarcoma    thyroiditis    neuronitis


    CARM1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CARM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 14.4 9 18172323 (4), 19183483 (1), 15525597 (1), 16938873 (1)
    necrosis 0 3 19769987 (1)
    tumors 0 6 16938873 (1), 18461904 (1), 19769987 (1)
    prostate cancer 0 4 16705743 (4)

    Genetic Association Database (GAD): CARM1
    Human Genome Epidemiology (HuGE) Navigator: CARM1 (5 documents)

    Export disorders for CARM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CARM1 gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with CARM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status. (PubMed id 15221992)1, 2, 9 Hong H.... Cheng L. (2004)
    2. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PubMed id 16497732)1, 2, 9 Miao F.... Natarajan R. (2006)
    3. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. (PubMed id 15471871)1, 2, 9 Ananthanarayanan M....Walsh M.J. (2004)
    4. Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax. (PubMed id 17005681)1, 2, 9 Jeong S.J.... Brady J.N. (2006)
    5. Biochemical control of CARM1 enzymatic activity by ph osphorylation. (PubMed id 19843527)1, 2, 9 Feng Q....O'Malley B.W. (2009)
    6. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. (PubMed id 12237300)1, 2, 9 Li H.... Laird-Offringa I.A. (2002)
    7. Regulation of transcription by a protein methyltransferase. (PubMed id 10381882)1, 3, 9 Chen D....Stallcup M.R. (1999)
    8. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. (PubMed id 15731352)1, 2, 9 Lee Y.-H.... Stallcup M.R. (2005)
    9. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4, 9 Haiman C.A....Press M.F. (2009)
    10. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. (PubMed id 11724789)1, 3, 9 Frankel A....Bedford M.T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10498 HGNC: 23393 AceView: CARM1 Ensembl:ENSG00000142453 euGenes: HUgn10498
    ECgene: CARM1 H-InvDB: CARM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CARM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CARM1 gene:
    Search GeneIP for patents involving CARM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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