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CARM1 Gene

protein-coding   GIFtS: 66
GCID: GC19P010982

Coactivator-Associated Arginine Methyltransferase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coactivator-Associated Arginine Methyltransferase 11 2 3     EC 2.1.1.-3
PRMT42 3 5     EC 2.1.1.1253
Protein Arginine N-Methyltransferase 42 3     EC 2.1.18
Histone-Arginine Methyltransferase CARM12     

External Ids:    HGNC: 233931   Entrez Gene: 104982   Ensembl: ENSG000001424537   OMIM: 6039345   UniProtKB: Q86X553   

Export aliases for CARM1 gene to outside databases

Previous GC identifers: GC19P011113 GC19P010827 GC19P010843 GC19P010560


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CARM1 Gene:
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the
methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and
other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in
association with other proteins or within multi-protein complexes and may play a role in cell type-specific
functions and cell lineage specification. A related pseudogene is located on chromosome 9. (provided by RefSeq,
Aug 2013)

GeneCards Summary for CARM1 Gene:
CARM1 (coactivator-associated arginine methyltransferase 1) is a protein-coding gene. Diseases associated with CARM1 include sporadic breast cancer, and spina bifida. GO annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
Function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several
proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to
promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families,
methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to
activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4
activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1,
NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional
activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation,
acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte
differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative
splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation.
Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580'
and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent
transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4,
which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CARM1 gene promoter:
         GR   CREB   PPAR-gamma1   GR-beta   deltaCREB   GR-alpha   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCARM1 promoter sequence
   Search Chromatin IP Primers for CARM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

CARM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARM1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010982:  view genomic region     (about GC identifiers)

Start:
10,982,189 bp from pter      End:
11,033,453 bp from pter
Size:
51,265 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55 (See protein sequence)
Recommended Name: Histone-arginine methyltransferase CARM1  
Size: 608 amino acids; 65854 Da
Subunit: Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a
complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2,
EP300/P300, TRIM24, CREBBP and CTNNB1. Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1.
Interacts with NCOA3/SRC3. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA.
Interacts with HTLV-1 Tax-1
3 PDB 3D structures from and Proteopedia for CARM1:
2Y1W (3D)        2Y1X (3D)        4IKP (3D)    
Secondary accessions: A6NN38
Alternative splicing: 3 isoforms:  Q86X55-3   Q86X55-1   Q86X55-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CARM1: NX_Q86X55

Explore proteomics data for CARM1 at MOPED

Post-translational modifications: 

  • Auto-methylated on Arg-550. Methylation enhances transcription coactivator activity. Methylation is required for
    its role in the regulation of pre-mRNA alternative splicing (By similarity)1
  • Phosphorylation at Ser-216 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase
    activity (By similarity). Phosphorylation at Ser-216 is strongly increased during mitosis, and decreases rapidly
    to a very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-216 may
    promote location in the cytosol1
  • Ubiquitination2 at Lys227, Lys470
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for CARM1 (Q86X55)
     GCGSGIL  VLDVGCG  DKIVLDVG 


    See CARM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_954592.1  
    ENSEMBL proteins: 
     ENSP00000325690   ENSP00000465417   ENSP00000467420   ENSP00000340934   ENSP00000467746  
     ENSP00000464852   ENSP00000468319   ENSP00000467761  
    Reactome Protein details: Q86X55

    CARM1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CARM1 Protein
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    OriGene Protein Over-expression Lysate for CARM1
    OriGene MassSpec for CARM1
    OriGene Custom Protein Services for CARM1
    GenScript Custom Purified and Recombinant Proteins Services for CARM1
    Novus Biologicals CARM1 Protein
    Novus Biologicals CARM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CARM1

    CARM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CARM1
    R&D Systems Antibodies for CARM1
    Cell Signaling Technology (CST) Antibodies for CARM1 
    OriGene Antibodies for CARM1
    OriGene Custom Antibody Services for CARM1
    Novus Biologicals CARM1 Antibodies
    Abcam antibodies for CARM1
    Cloud-Clone Corp. Antibodies for CARM1
    ThermoFisher Antibody for CARM1
    LSBio Antibodies in human, mouse, rat for CARM1

    CARM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CARM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CARM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CARM1
    Cloud-Clone Corp. CLIAs for CARM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT4
    Protein arginine N-methyltransferases

    2 InterPro protein domains:
     IPR025799 Arg_MeTrfase
     IPR020989 Histone-Arg_MeTrfase_N

    Graphical View of Domain Structure for InterPro Entry Q86X55

    ProtoNet protein and cluster: Q86X55

    UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine
    N-methyltransferase family
    Similarity: Contains 1 SAM-dependent MTase PRMT-type domain


    CARM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CARM1_HUMAN, Q86X55
    Function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several
    proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to
    promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families,
    methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to
    activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4
    activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1,
    NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional
    activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation,
    acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte
    differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative
    splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation.
    Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580'
    and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent
    transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4,
    which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs
    Catalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine +
    N(omega)-methyl-arginine-[histone]
    Enzyme regulation: Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 'Lys-18'
    (H3K18ac) H3 'Lys-23' (H3K23ac) by EP300 and blocked by citrullination of H3 'Arg-17' (H3R17ci) by PADI4 (By
    similarity)

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.1251

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding IPI--
    GO:0008013beta-catenin binding TAS16344550
    GO:0008168methyltransferase activity ----
    GO:0008276protein methyltransferase activity ISS--
         
    CARM1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CARM1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Carm1):
     adipose tissue  growth/size/body  hematopoietic system  immune system  mortality/aging 
     respiratory system 

    CARM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Carm1tm1Mtb for CARM1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CARM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CARM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CARM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CARM1:
    hsa-let-7e-5p (MIRT051469), hsa-mir-92a-3p (MIRT049639)

    Block miRNA regulation of human, mouse, rat CARM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CARM1 (see all 41):
    hsa-miR-579 hsa-miR-15a hsa-miR-9 hsa-miR-424 hsa-miR-15b hsa-miR-626 hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCARM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CARM1
    Predesigned siRNA for gene silencing in human, mouse, rat CARM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CARM1

    Clone
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    OriGene clones in human, mouse for CARM1 (see all 8)
    OriGene ORF clones in mouse, rat for CARM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CARM1 (NM_199141)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARM1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CARM1_HUMAN, Q86X55: Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle.
    Cytoplasmic during mitosis, after breakup of the nuclear membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15221992
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA15221992
    GO:0005829cytosol ISS--

    CARM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CARM1 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Circadian Repression of Expression by REV-ERBA
    Circadian Repression of Expression by REV-ERBA0.88
    YAP1- and WWTR1 (TAZ)-stimulated gene expression0.40
    RORA Activates Circadian Expression0.88
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    Activation of Gene Expression by SREBP (SREBF)0.75
    4Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66
    5Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CARM1
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    1 Cell Signaling Technology (CST) Pathway for CARM1
        Chromatin Regulation / Acetylation

    5 GeneGo (Thomson Reuters) Pathways for CARM1
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Cell cycle ESR1 regulation of G1/S transition
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Function of MEF2 in T lymphocytes

    4 BioSystems Pathways for CARM1
        Androgen receptor signaling pathway
    Direct p53 effectors
    Regulation of Androgen receptor activity
    Coregulation of Androgen receptor activity

    Selected Reactome Pathways for CARM1 (see all 10)
        Transcriptional regulation of white adipocyte differentiation
    Circadian Clock
    Transcriptional activation of mitochondrial biogenesis
    YAP1- and WWTR1 (TAZ)-stimulated gene expression
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)



    CARM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CARM1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CARM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CARM1 (Q86X551, 2, 3 ENSP000003256904) via UniProtKB, MINT, STRING, and/or I2D (see all 234)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003420regulation of growth plate cartilage chondrocyte proliferation IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ISS--
    GO:0006479protein methylation ----
    GO:0008152metabolic process ----

    CARM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CARM1

    2 HMDB Compounds for CARM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    8 Novoseek inferred chemical compound relationships for CARM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 83.3 150 16497732 (3), 11341840 (3), 18280497 (3), 11050077 (2) (see all 59)
    estrogen 51.1 18 18172323 (5), 11010967 (2), 17640894 (2), 20360387 (1) (see all 6)
    s-adenosylmethionine 47.8 4 10381882 (1), 19843527 (1), 17640894 (1)
    steroid 45.1 15 19183483 (1), 14500758 (1), 15731352 (1), 18048071 (1) (see all 8)
    retinoid 40.5 4 15731352 (1), 15525597 (1)
    cyclic amp 4.11 3 15525597 (1), 16254053 (1)
    testosterone 0 12 16705743 (4), 16492776 (1)
    creatinine 0 1 11713257 (1)



    CARM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CARM1 gene: 
    NM_199141.1  

    Unigene Cluster for CARM1:

    Coactivator-associated arginine methyltransferase 1
    Hs.323213  [show with all ESTs]
    Unigene Representative Sequence: NM_199141
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327064(uc002mpz.3 uc010dxn.3) ENST00000588947 ENST00000590699
    ENST00000344150(uc002mqa.3) ENST00000586221 ENST00000590039 ENST00000589693
    ENST00000586508 ENST00000586298 ENST00000592516
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CARM1 (see all 41):
    hsa-miR-579 hsa-miR-15a hsa-miR-9 hsa-miR-424 hsa-miR-15b hsa-miR-626 hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCARM1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CARM1 (NM_199141)
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      QuantiTect SYBR Green Assays in human, mouse, rat CARM1
      QuantiFast Probe-based Assays in human, mouse, rat CARM1

    Additional mRNA sequence: 

    AF055027.1 AL833242.1 BC036886.1 BC046240.1 BC070496.1 

    18 DOTS entries:

    DT.100661719  DT.97775761  DT.100883379  DT.85104699  DT.100883374  DT.100883380  DT.97855195  DT.97855194 
    DT.100709504  DT.220742  DT.121457088  DT.75155444  DT.75182575  DT.97802100  DT.100681577  DT.100686557 
    DT.100883383  DT.95270450 

    Selected AceView cDNA sequences (see all 311):

    BQ015200 BM743234 CD370742 BM727224 AI200775 BQ003514 BC070496 AA316660 
    AL833242 CA422645 BE501369 BI822191 AW342049 BI258584 AI369610 F36282 
    BM793780 AW662503 AL043354 BU552954 BQ962620 BU174647 AI601222 BQ278927 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CARM1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                                                                -           -                                                               
    SP2:                                                                                -           -     -                                                         
    SP3:                                                                                -           -     -                                                         
    SP4:                                                                                -           -     -                                                         
    SP5:                                                                                -           -     -                                                         

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CARM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CARM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTTTTTT
    CARM1 Expression
    About this image


    CARM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Neural Tube (Nervous System)
             Metencephalon
    CARM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CARM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.323213

    UniProtKB/Swiss-Prot: CARM1_HUMAN, Q86X55
    Tissue specificity: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia

        Pathway & Disease-focused RT2 Profiler PCR Array including CARM1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CARM1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Carm11 , 5 coactivator-associated arginine methyltransferase 11, 5 90.51(n)1
    97.6(a)1
      9 (7.82 cM)5
    590351  NM_021531.61  NP_067506.21 
     215468945 
    lizard
    (Anolis carolinensis)
    Reptilia CARM16
    coactivator-associated arginine methyltransferase ...
    95(a)
    1 ↔ 1
    2(80849536-80876217)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.96442 Xenopus laevis transcribed sequence with weak similarity more 80.83(n)    CA787702.1 
    zebrafish
    (Danio rerio)
    Actinopterygii btg12 B-cell translocation gene 1 76.55(n)    BM530251.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53583
    Art41
    protein-arginine N-methyltransferase3
    Arginine methyltransferase 41
    59(a)
    (best of 2)3
    60.64(n)1
    60.41(a)1
      85F43
    412191  NM_141706.31  NP_649963.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HMT16
    Nuclear SAM-dependent mono- and asymmetric arginin...
    33(a)
    1 → many
    II(304930-305976) YBR034C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PRMT4B1 PRMT4B 52.93(n)
    48.74(a)
      819878  NM_180197.2  NP_850528.1 
    rice
    (Oryza sativa)
    Liliopsida Os.107782 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 67.94(n)    AK065980.1 


    ENSEMBL Gene Tree for CARM1 (if available)
    TreeFam Gene Tree for CARM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CARM1 gene
    PRMT62  PRMT32  PRMT22  PRMT12  PRMT82  
    4 SIMAP similar genes for CARM1 using alignment to 7 protein entries:     CARM1_HUMAN (see all proteins):
    PRMT1    PRMT2    PRMT8    PRMT6

    CARM1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CARM1
    PGOHUM00000250487


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CARM1 (see all 1036)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819226271,2
    --10980901(+) GTGGCC/TCATGC 1 -- us2k10--------
    rs1847403701,2
    --10980929(+) TGGGAG/TGCCGA 1 -- us2k10--------
    rs1895049251,2
    --10980956(+) GAAGTC/TAGGAG 1 -- us2k10--------
    rs124604211,2
    C,F,H--10981352(+) GGGCCA/GGGCTG 1 -- us2k124Minor allele frequency- G:0.48NS EA NA WA CSA 2704
    rs1395568231,2
    --10981633(+) GCCCAA/TTCCCC 1 -- us2k10--------
    rs1497308841,2
    C--10981811(+) AAGCCG/TCATCA 1 -- us2k10--------
    rs1175698511,2
    C,F--10981992(+) CGACGT/CACCCT 1 -- us2k12Minor allele frequency- C:0.39NA EA 240
    rs1124388921,2
    C--10982190(+) GGCGAA/GGCGGC 1 -- us2k10--------
    rs1489567311,2
    --10983286(+) AGCCTC/TCTCCC 1 -- int10--------
    rs1470239791,2
    --10983331(+) TTTTCC/TGAAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CARM1 (10982189 - 11033453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CARM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911050CNV Loss21882294
    nsv911051CNV Loss21882294
    nsv833749CNV Loss17160897
    nsv833748CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603934    OMIM disorders: --

    20 diseases for CARM1:    
    About MalaCards
    sporadic breast cancer    spina bifida    spinal muscular atrophy    muscular atrophy
    prostate adenocarcinoma    rhabdomyosarcoma    kaposi's sarcoma    breast cancer
    prostatitis    sarcoma    prostate cancer    tonsillitis
    thyroiditis    colorectal cancer    adenocarcinoma    melanoma
    malaria    cerebritis    neuronitis    endotheliitis


    CARM1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CARM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 14.4 9 18172323 (4), 19183483 (1), 15525597 (1), 16938873 (1)
    necrosis 0 3 19769987 (1)
    tumors 0 6 16938873 (1), 18461904 (1), 19769987 (1)
    prostate cancer 0 4 16705743 (4)

    Genetic Association Database (GAD): CARM1
    Human Genome Epidemiology (HuGE) Navigator: CARM1 (5 documents)

    Export disorders for CARM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CARM1 gene, integrated from 10 sources (see all 156):
    (articles sorted by number of sources associating them with CARM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status. (PubMed id 15221992)1, 2, 9 Hong H.... Cheng L. (Cancer 2004)
    2. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PubMed id 16497732)1, 2, 9 Miao F.... Natarajan R. (Mol. Endocrinol. 2006)
    3. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. (PubMed id 15471871)1, 2, 9 Ananthanarayanan M....Walsh M.J. (J. Biol. Chem. 2004)
    4. Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax. (PubMed id 17005681)1, 2, 9 Jeong S.J.... Brady J.N. (J. Virol. 2006)
    5. Biochemical control of CARM1 enzymatic activity by phosphorylation. (PubMed id 19843527)1, 2, 9 Feng Q....O'Malley B.W. (J. Biol. Chem. 2009)
    6. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. (PubMed id 12237300)1, 2, 9 Li H.... Laird-Offringa I.A. (J. Biol. Chem. 2002)
    7. Regulation of transcription by a protein methyltransferase. (PubMed id 10381882)1, 3, 9 Chen D....Stallcup M.R. (Science 1999)
    8. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. (PubMed id 15731352)1, 2, 9 Lee Y.-H.... Stallcup M.R. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    9. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4, 9 Haiman C.A....Press M.F. (BMC Cancer 2009)
    10. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. (PubMed id 11724789)1, 3, 9 Frankel A....Bedford M.T. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10498 HGNC: 23393 AceView: CARM1 Ensembl:ENSG00000142453 euGenes: HUgn10498
    ECgene: CARM1 H-InvDB: CARM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CARM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CARM1 gene:
    Search GeneIP for patents involving CARM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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