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Aliases for CARKD Gene

Aliases for CARKD Gene

  • Carbohydrate Kinase Domain Containing 2 3
  • Carbohydrate Kinase Domain-Containing Protein 3 4
  • ATP-Dependent NAD(P)HX Dehydratase 3 4
  • EC 4.2.1.93 4
  • LP3298 3

External Ids for CARKD Gene

Previous GeneCards Identifiers for CARKD Gene

  • GC13P110067
  • GC13P111267
  • GC13P091867

Summaries for CARKD Gene

GeneCards Summary for CARKD Gene

CARKD (Carbohydrate Kinase Domain Containing) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent NAD(P)H-hydrate dehydratase activity and ADP-dependent NAD(P)H-hydrate dehydratase activity.

UniProtKB/Swiss-Prot for CARKD Gene

  • Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Gene Wiki entry for CARKD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARKD Gene

Genomics for CARKD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CARKD Gene

Chromosome:
13
Start:
110,615,460 bp from pter
End:
110,639,996 bp from pter
Size:
24,537 bases
Orientation:
Plus strand

Genomic View for CARKD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARKD Gene

Proteins for CARKD Gene

  • Protein details for CARKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW45-NNRD_HUMAN
    Recommended name:
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
    Protein Accession:
    Q8IW45
    Secondary Accessions:
    • B4DXT4
    • Q5T9X3
    • Q9H7W1
    • Q9NVF5

    Protein attributes for CARKD Gene

    Size:
    347 amino acids
    Molecular mass:
    36576 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CARKD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARKD Gene

Proteomics data for CARKD Gene at MOPED

Post-translational modifications for CARKD Gene

  • Glycosylation at Asn 240 and Asn 297
  • Modification sites at PhosphoSitePlus

Other Protein References for CARKD Gene

No data available for DME Specific Peptides for CARKD Gene

Domains & Families for CARKD Gene

Protein Domains for CARKD Gene

Suggested Antigen Peptide Sequences for CARKD Gene

Graphical View of Domain Structure for InterPro Entry

Q8IW45

UniProtKB/Swiss-Prot:

NNRD_HUMAN :
  • Contains 1 YjeF C-terminal domain.
  • Belongs to the NnrD/CARKD family.
Domain:
  • Contains 1 YjeF C-terminal domain.
Family:
  • Belongs to the NnrD/CARKD family.
genes like me logo Genes that share domains with CARKD: view

No data available for Gene Families for CARKD Gene

Function for CARKD Gene

Molecular function for CARKD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH
UniProtKB/Swiss-Prot Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Enzyme Numbers (IUBMB) for CARKD Gene

Gene Ontology (GO) - Molecular Function for CARKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
GO:0005524 ATP binding IEA --
GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity IEA --
GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity IEA --
genes like me logo Genes that share ontologies with CARKD: view

Phenotypes for CARKD Gene

GenomeRNAi human phenotypes for CARKD:
genes like me logo Genes that share phenotypes with CARKD: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CARKD

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CARKD Gene

Localization for CARKD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARKD Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARKD Gene COMPARTMENTS Subcellular localization image for CARKD gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CARKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol --
genes like me logo Genes that share ontologies with CARKD: view

Pathways & Interactions for CARKD Gene

SuperPathways for CARKD Gene

No Data Available

Gene Ontology (GO) - Biological Process for CARKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CARKD: view

No data available for Pathways by source and SIGNOR curated interactions for CARKD Gene

Drugs & Compounds for CARKD Gene

(2) Drugs for CARKD Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
NADH Nutra 0

(3) Additional Compounds for CARKD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with CARKD: view

Transcripts for CARKD Gene

Unigene Clusters for CARKD Gene

Carbohydrate kinase domain containing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CARKD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARKD Gene

No ASD Table

Relevant External Links for CARKD Gene

GeneLoc Exon Structure for
CARKD
ECgene alternative splicing isoforms for
CARKD

Expression for CARKD Gene

mRNA expression in normal human tissues for CARKD Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARKD Gene



SOURCE GeneReport for Unigene cluster for CARKD Gene Hs.408324

genes like me logo Genes that share expression patterns with CARKD: view

Protein tissue co-expression partners for CARKD Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CARKD Gene

Orthologs for CARKD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CARKD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CARKD 35
  • 80.94 (n)
  • 82.11 (a)
CARKD 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARKD 35
  • 80.02 (n)
  • 78.48 (a)
CARKD 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Carkd 35
  • 82.06 (n)
  • 82.48 (a)
Carkd 16
Carkd 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CARKD 35
  • 98.85 (n)
  • 98.56 (a)
CARKD 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Carkd 35
  • 81.1 (n)
  • 81.85 (a)
oppossum
(Monodelphis domestica)
Mammalia CARKD 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves CARKD 35
  • 73.14 (n)
  • 76.11 (a)
CARKD 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CARKD 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia carkd 35
  • 70.85 (n)
  • 73.67 (a)
Str.9801 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12305 35
zebrafish
(Danio rerio)
Actinopterygii zgc:171429 35
  • 65.28 (n)
  • 68.05 (a)
CARKD 36
  • 29 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011983 35
  • 54.8 (n)
  • 50.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10424 35
  • 53.93 (n)
  • 48.93 (a)
CG10424 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R107.2 36
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR055W 35
  • 52.43 (n)
  • 49.11 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04510g 35
  • 49.65 (n)
  • 44.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKL151C 35
  • 48.83 (n)
  • 42.61 (a)
-- 36
  • 32 (a)
OneToOne
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19150 35
  • 49.23 (n)
  • 47.68 (a)
soybean
(Glycine max)
eudicotyledons Gma.4754 35
rice
(Oryza sativa)
Liliopsida Os.11423 35
Os11g0276300 35
  • 50.4 (n)
  • 48.79 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.13459 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02513 35
  • 49.83 (n)
  • 45.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC61.03 35
  • 50.06 (n)
  • 48.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for CARKD:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CARKD Gene

ENSEMBL:
Gene Tree for CARKD (if available)
TreeFam:
Gene Tree for CARKD (if available)

Paralogs for CARKD Gene

(1) SIMAP similar genes for CARKD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CARKD: view

No data available for Paralogs for CARKD Gene

Variants for CARKD Gene

Sequence variations from dbSNP and Humsavar for CARKD Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_043564 -
VAR_043565 -
VAR_043566 -

Structural Variations from Database of Genomic Variants (DGV) for CARKD Gene

Variant ID Type Subtype PubMed ID
nsv832720 CNV Loss 17160897
dgv1791n71 CNV Gain 21882294
nsv901012 CNV Loss 21882294
nsv525124 CNV Loss 19592680
nsv456120 CNV Loss 19166990
nsv901013 CNV Loss 21882294

Variation tolerance for CARKD Gene

Residual Variation Intolerance Score: 76.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARKD Gene

HapMap Linkage Disequilibrium report
CARKD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARKD Gene

Disorders for CARKD Gene

Relevant External Links for CARKD

Genetic Association Database (GAD)
CARKD
Human Genome Epidemiology (HuGE) Navigator
CARKD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARKD
genes like me logo Genes that share disorders with CARKD: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARKD Gene

Publications for CARKD Gene

  1. Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. (PMID: 21994945) Marbaix A.Y. … Linster C.L. (J. Biol. Chem. 2011) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Occurrence and subcellular distribution of the NADPHX repair system in mammals. (PMID: 24611804) Marbaix A.Y. … Van Schaftingen E. (Biochem. J. 2014) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for CARKD Gene

Sources for CARKD Gene

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