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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARKD Gene

protein-coding   GIFtS: 46
GCID: GC13P111267

carbohydrate kinase domain containing

 Explore 3 diseases affiliated with
CARKD via our new
 Human Malady Compendium 
Biological research products
for CARKD
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Carbohydrate Kinase Domain Containing1 2     FLJ107691
LP32981 2     ATP-Dependent (S)-NAD(P)H-Hydrate Dehydratase2
Carbohydrate Kinase Domain-Containing Protein2 3     EC 4.2.1.933
ATP-Dependent NAD(P)HX Dehydratase2 3     

External Ids:    HGNC: 255761   Entrez Gene: 557392   Ensembl: ENSG000002139957   UniProtKB: Q8IW453   
ORGUL members:         
NONCODE:n411640    

Export aliases for CARKD gene to outside databases

Previous GC identifers: GC13P110067 GC13P091867


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NNRD_HUMAN, Q8IW45
Function: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP.
Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the
repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent
hydration (By similarity)

Gene Wiki entry for CARKD


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARKD gene promoter:
         Max1   GR   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   C/EBPalpha   GATA-2   PPAR-alpha   S8   Nkx6-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCARKD promoter sequence
   Search SABiosciences Chromatin IP Primers for CARKD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARKD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

CARKD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARKD gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P111267:  view genomic region     (about GC identifiers)

Start:
111,267,881 bp from pter      End:
111,292,343 bp from pter
Size:
24,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NNRD_HUMAN, Q8IW45 (See protein sequence)
Recommended Name: ATP-dependent (S)-NAD(P)H-hydrate dehydratase precursor  
Size: 347 amino acids; 36576 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: B4DXT4 Q5T9X3 Q9H7W1 Q9NVF5
Alternative splicing: 4 isoforms:  Q8IW45-1   Q8IW45-2   Q8IW45-3   Q8IW45-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CARKD: NX_Q8IW45

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IW45

  • CARKD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001229810.1  NP_001229811.1  NP_001229812.1  NP_060680.2  

    ENSEMBL proteins: 
     ENSP00000311984   ENSP00000412789   ENSP00000413191   ENSP00000380375  

    Human Recombinant Protein Products: 
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    Novus Biologicals CARKD Protein
    Novus Biologicals CARKD Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CARKD

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--


    CARKD for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CARKD


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CARKD for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000631 YjeF_C_carb_kinase-rel
     IPR026599 NnrD/CARKD

    Graphical View of Domain Structure for InterPro Entry Q8IW45

    ProtoNet protein and cluster: Q8IW45

    1 Blocks protein family: IPB000631 Protein of unknown function UPF0031

    UniProtKB/Swiss-Prot: NNRD_HUMAN, Q8IW45
    Similarity: Belongs to the nnrD/CARKD family
    Similarity: Contains 1 YjeF C-terminal domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NNRD_HUMAN, Q8IW45
    Function: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP.
    Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the
    repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent
    hydration (By similarity)
    Catalytic activity: ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate +
    NADH
    Catalytic activity: ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP +
    phosphate + NADPH

    Enzyme Number (IUBMB): EC 4.2.1.931

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005524ATP binding IEA--
    GO:0047453ATP-dependent NAD(P)H-hydrate dehydratase activity IEA--


    CARKD for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CARKD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/17 Interacting proteins for CARKD (Q8IW453 ENSP000003119844) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTMT1Q9BV863, ENSP000003615584I2D: score=2 STRING: ENSP00000361558
    APOA1BPQ8NCW53, ENSP000003572184I2D: score=1 STRING: ENSP00000357218
    POLR2BP308763, ENSP000003127354I2D: score=1 STRING: ENSP00000312735
    DCP1BQ8IZD43I2D: score=5 
    CAMK1DQ8IU853I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0046496nicotinamide nucleotide metabolic process IEA--


    CARKD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CARKD
    Search CenterWatch for drugs/clinical trials and news about CARKD / NNRD 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CARKD gene (4 alternative transcripts): 
    NM_001242881.1  NM_001242882.1  NM_001242883.1  NM_018210.3  

    Unigene Cluster for CARKD:

    Carbohydrate kinase domain containing
    Hs.408324  [show with all ESTs]
    Unigene Representative Sequence: NM_018210
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492889 ENST00000470164(uc001vra.3 uc010tjk.2 uc010tjl.2 uc021rmn.1)
    ENST00000309957(uc010tjj.2 uc001vqz.3 uc001vrb.3 uc001vrc.3)
    ENST00000458711 ENST00000424185 ENST00000397191(uc010tji.2)

    miRNA
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    hsa-miR-633 hsa-miR-3148
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF091088.1 AF151071.1 AK001631.1 AK024260.1 AK093771.1 AK095260.1 AK225129.1 AK296758.1 
    AK298917.1 AK302117.1 BC005150.2 BC006416.1 BC041028.1 NR_040103.1 NR_040104.1 

    24/31 DOTS entries (see all 31):

    DT.91854348  DT.418917  DT.100791636  DT.100791645  DT.120787690  DT.100791642  DT.102843366  DT.100791639 
    DT.120787584  DT.120787686  DT.91884566  DT.97781647  DT.120787539  DT.100791641  DT.120787694  DT.92435618 
    DT.100791643  DT.92435624  DT.99937329  DT.120787565  DT.120787638  DT.95374624  DT.100791644  DT.120787543 

    24/461 AceView cDNA sequences (see all 461):

    AI342787 T60958 AK093771 AA598872 AA975682 CA437650 BM830518 BM977421 
    BM721522 AI200683 NM_198219 BM457587 AI056700 NM_198218 AU131402 AJ310392 
    AW469145 BE378238 BQ883042 AA151323 AA235078 CA424117 AY203948 AI670736 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CARKD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACATTTTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CARKD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CARKD

    SOURCE GeneReport for Unigene cluster: Hs.408324
        SABiosciences Custom PCR Arrays for CARKD
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARKD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CARKD gene from 11/40 species (see all 40)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Carkd1 , 5 carbohydrate kinase domain containing1, 5 80.06(n)1
    79.77(a)1
      8 (5.73 cM)5
    692251  NM_026995.41  NP_081271.21 
     114975065 
    chicken
    (Gallus gallus)
    Aves CARKD1 carbohydrate kinase domain containing 71.59(n)
    74.77(a)
      418755  XM_416954.3  XP_416954.3 
    lizard
    (Anolis carolinensis)
    Reptilia CARKD6
    --
    61(a)
    1 ↔ 1
    3(104436808-104449378)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123052 Xenopus laevis transcribed sequence with weak similarity more 75.72(n)    BX846804.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF995974.12   -- 71.86(n)    CF995974.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104241 CG10424 53.88(n)
    49.1(a)
      40085  NM_140833.3  NP_649090.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R107.26
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
    36(a)
    1 ↔ 1
    III(9043803-9045862)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YKL151C)4
    YKL151C1
    Putative protein of unknown function; YKL151C promoter more4
    hypothetical protein1
    48.71(n)1
    42.61(a)1
      11(165930-164917)4
    8537061, 4  NP_012771.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G191501 pfkB-like carbohydrate kinase family protein 50.06(n)
    49.13(a)
      832035  NM_203082.1  NP_974811.1 
    rice
    (Oryza sativa)
    Liliopsida Os.114232 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.68(n)    AK103343.1 


    ENSEMBL Gene Tree for CARKD (if available)
    TreeFam Gene Tree for CARKD (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/612 NCBI SNPs in CARKD are shown (see all 612    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461301541,2
    --111265899(+) TGGGTC/TGAGTG 4 -- us2k10--------
    rs1113670531,2
    F,--111265930(+) GTCTTG/ACAAGA 4 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs1850227871,2
    --111266029(+) ATGCAC/TCAATC 6 -- us2k10--------
    rs1899075901,2
    --111266031(+) GCACCA/GATCAG 6 -- us2k10--------
    rs1816114831,2
    --111266032(+) CACCAA/GTCAGT 6 -- us2k10--------
    rs1165416191,2
    F,--111266169(+) CCCACC/GCCCCC 6 -- us2k11Minor allele frequency- G:0.05WA 118
    rs21480781,2
    F,H,--111266174(-) GGGGTG/CGGGGG 6 -- us2k16Minor allele frequency- C:0.04NS EA NA 422
    rs1487478421,2
    --111266248(+) CTCTTC/TATAAT 6 -- us2k10--------
    rs95882071,2
    C,A,--111266257(+) atgaaT/Actttt 6 -- us2k14Minor allele frequency- A:0.12NA CSA WA 241
    rs1130885651,2
    --111266289(+) GTCTCG/ACTCTG 6 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for CARKD (111267881 - 111292343 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CARKD: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARKD
    DNA2.0 Custom Variant and Variant Library Synthesis for CARKD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CARKD for disorders           About GeneDecksing

    3 diseases for CARKD:    About MalaCards
    tuberculosis    malaria    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: CARKD (2 documents)

    Export disorders for CARKD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CARKD gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CARKD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    5. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1 Zhang Q.-H.... Chen Z. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55739 HGNC: 25576 AceView: ING1andFLJ10769 Ensembl:ENSG00000213995 euGenes: HUgn55739
    ECgene: CARKD H-InvDB: CARKD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CARKD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CARKD gene:
    Search GeneIP for patents involving CARKD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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