Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CARKD Gene

Aliases for CARKD Gene

  • Carbohydrate Kinase Domain Containing 2 3
  • Carbohydrate Kinase Domain-Containing Protein 3 4
  • ATP-Dependent NAD(P)HX Dehydratase 3 4
  • ATP-Dependent (S)-NAD(P)H-Hydrate Dehydratase 3
  • EC 4.2.1.93 4
  • LP3298 3

External Ids for CARKD Gene

Summaries for CARKD Gene

GeneCards Summary for CARKD Gene

CARKD (Carbohydrate Kinase Domain Containing) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent NAD(P)H-hydrate dehydratase activity.

UniProtKB/Swiss-Prot for CARKD Gene

  • Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Gene Wiki entry for CARKD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARKD Gene

Genomics for CARKD Gene

Genomic Location for CARKD Gene

Start:
110,615,460 bp from pter
End:
110,639,996 bp from pter
Size:
24,537 bases
Orientation:
Plus strand

Genomic View for CARKD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARKD Gene

Proteins for CARKD Gene

  • Protein details for CARKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW45-NNRD_HUMAN
    Recommended name:
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
    Protein Accession:
    Q8IW45
    Secondary Accessions:
    • B4DXT4
    • Q5T9X3
    • Q9H7W1
    • Q9NVF5

    Protein attributes for CARKD Gene

    Size:
    347 amino acids
    Molecular mass:
    36576 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CARKD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARKD Gene

Proteomics data for CARKD Gene at MOPED

Post-translational modifications for CARKD Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn240 and Asn297

Other Protein References for CARKD Gene

No data available for DME Specific Peptides for CARKD Gene

Domains for CARKD Gene

Protein Domains for CARKD Gene

UniProtKB/Swiss-Prot:

NNRD_HUMAN
Domain:
  • Contains 1 YjeF C-terminal domain.:
    • Q8IW45
Family:
  • Belongs to the NnrD/CARKD family.:
    • Q8IW45
genes like me logo Genes that share domains with CARKD: view

No data available for Gene Families for CARKD Gene

Function for CARKD Gene

Molecular function for CARKD Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH
UniProtKB/Swiss-Prot Function: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Enzyme Numbers (IUBMB) for CARKD Gene

Gene Ontology (GO) - Molecular Function for CARKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
GO:0005524 ATP binding IEA --
GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity IEA --
GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity IEA --
genes like me logo Genes that share ontologies with CARKD: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CARKD Gene

Localization for CARKD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARKD Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARKD Gene COMPARTMENTS Subcellular localization image for CARKD gene
Compartment Confidence
extracellular 2
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CARKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CARKD: view

Pathways for CARKD Gene

SuperPathways for CARKD Gene

No Data Available

Gene Ontology (GO) - Biological Process for CARKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0046496 nicotinamide nucleotide metabolic process IEA --
genes like me logo Genes that share ontologies with CARKD: view

No data available for Pathways by source for CARKD Gene

Transcripts for CARKD Gene

Unigene Clusters for CARKD Gene

Carbohydrate kinase domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARKD Gene

No ASD Table

Relevant External Links for CARKD Gene

GeneLoc Exon Structure for
CARKD
ECgene alternative splicing isoforms for
CARKD

Expression for CARKD Gene

mRNA expression in normal human tissues for CARKD Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARKD Gene

SOURCE GeneReport for Unigene cluster for CARKD Gene Hs.408324

genes like me logo Genes that share expressions with CARKD: view

Orthologs for CARKD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CARKD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CARKD 36
  • 98.85 (n)
  • 98.56 (a)
CARKD 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CARKD 36
  • 80.94 (n)
  • 82.11 (a)
CARKD 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARKD 36
  • 80.02 (n)
  • 78.48 (a)
CARKD 37
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Carkd 36
  • 82.06 (n)
  • 82.48 (a)
Carkd 16
Carkd 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CARKD 37
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 63 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Carkd 36
  • 81.1 (n)
  • 81.85 (a)
chicken
(Gallus gallus)
Aves CARKD 36
  • 73.14 (n)
  • 76.11 (a)
CARKD 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CARKD 37
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12305 36
tropical clawed frog
(Silurana tropicalis)
Amphibia carkd 36
  • 70.85 (n)
  • 73.67 (a)
Str.9801 36
zebrafish
(Danio rerio)
Actinopterygii CARKD 37
  • 29 (a)
OneToOne
zgc:171429 36
  • 65.28 (n)
  • 68.05 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011983 36
  • 54.8 (n)
  • 50.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10424 36
  • 53.93 (n)
  • 48.93 (a)
CG10424 37
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R107.2 37
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR055W 36
  • 52.43 (n)
  • 49.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 32 (a)
OneToOne
-- 39
YKL151C 36
  • 48.83 (n)
  • 42.61 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04510g 36
  • 49.65 (n)
  • 44.33 (a)
soybean
(Glycine max)
eudicotyledons Gma.4754 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19150 36
  • 49.23 (n)
  • 47.68 (a)
rice
(Oryza sativa)
Liliopsida Os.11423 36
Os11g0276300 36
  • 50.4 (n)
  • 48.79 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.13459 36
bread mold
(Neurospora crassa)
Ascomycetes NCU02513 36
  • 49.83 (n)
  • 45.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC61.03 36
  • 50.06 (n)
  • 48.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToOne
Species with no ortholog for CARKD:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CARKD Gene

ENSEMBL:
Gene Tree for CARKD (if available)
TreeFam:
Gene Tree for CARKD (if available)

Paralogs for CARKD Gene

Selected SIMAP similar genes for CARKD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CARKD: view

No data available for Paralogs for CARKD Gene

Variants for CARKD Gene

Sequence variations from dbSNP and Humsavar for CARKD Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs7394 -- 110,639,697(-) AAAGA(C/T)GCTAC utr-variant-3-prime, nc-transcript-variant
rs179356 -- 110,634,260(+) ACTGG(A/G)TAATT intron-variant
rs191322 -- 110,638,017(-) GAATG(G/T)GGATT intron-variant
rs330542 -- 110,619,028(-) GCCCA(C/G)CACTC intron-variant
rs330543 -- 110,618,923(-) GCTCC(C/T)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARKD Gene

Variant ID Type Subtype PubMed ID
nsv832720 CNV Loss 17160897
dgv1791n71 CNV Gain 21882294
nsv901012 CNV Loss 21882294
nsv525124 CNV Loss 19592680
nsv456120 CNV Loss 19166990
nsv901013 CNV Loss 21882294

Relevant External Links for CARKD Gene

HapMap Linkage Disequilibrium report
CARKD

Disorders for CARKD Gene

Relevant External Links for CARKD

Genetic Association Database (GAD)
CARKD
Human Genome Epidemiology (HuGE) Navigator
CARKD
genes like me logo Genes that share disorders with CARKD: view

No data available for UniProtKB/Swiss-Prot for CARKD Gene

Publications for CARKD Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. (PMID: 21994945) Marbaix A.Y. … Linster C.L. (J. Biol. Chem. 2011) 2 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for CARKD Gene

Sources for CARKD Gene

Back to Top

Content