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Aliases for CARHSP1 Gene

Aliases for CARHSP1 Gene

  • Calcium Regulated Heat Stable Protein 1, 24kDa 2 3
  • Calcium-Regulated Heat-Stable Protein Of 24 KDa 3 4
  • CRHSP-24 3 4
  • Calcium Regulated Heat Stable Protein 1 (24kD) 2
  • Calcium-Regulated Heat-Stable Protein (24kD) 3
  • Calcium-Regulated Heat Stable Protein 1 3
  • CSDC1 3

External Ids for CARHSP1 Gene

Summaries for CARHSP1 Gene

GeneCards Summary for CARHSP1 Gene

CARHSP1 (Calcium Regulated Heat Stable Protein 1, 24kDa) is a Protein Coding gene. GO annotations related to this gene include phosphatase binding and mRNA 3-UTR binding. An important paralog of this gene is CSDC2.

UniProtKB/Swiss-Prot for CARHSP1 Gene

  • Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).

Gene Wiki entry for CARHSP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARHSP1 Gene

Genomics for CARHSP1 Gene

Genomic Location for CARHSP1 Gene

Start:
8,852,942 bp from pter
End:
8,869,012 bp from pter
Size:
16,071 bases
Orientation:
Minus strand

Genomic View for CARHSP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARHSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARHSP1 Gene

Regulatory Elements for CARHSP1 Gene

Proteins for CARHSP1 Gene

  • Protein details for CARHSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2V2-CHSP1_HUMAN
    Recommended name:
    Calcium-regulated heat stable protein 1
    Protein Accession:
    Q9Y2V2
    Secondary Accessions:
    • B2R4C3
    • D3DUF5
    • Q2YDX5
    • Q9BQ53

    Protein attributes for CARHSP1 Gene

    Size:
    147 amino acids
    Molecular mass:
    15892 Da
    Quaternary structure:
    • Homodimer. Interacts with STYX (By similarity).

    Three dimensional structures from OCA and Proteopedia for CARHSP1 Gene

neXtProt entry for CARHSP1 Gene

Proteomics data for CARHSP1 Gene at MOPED

Post-translational modifications for CARHSP1 Gene

  • Dephosphorylated by calcineurin in a Ca(2+) dependent manner (By similarity). Can be phosphorylated by DYRK2 (in vitro).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys64

No data available for DME Specific Peptides for CARHSP1 Gene

Domains for CARHSP1 Gene

UniProtKB/Swiss-Prot:

CHSP1_HUMAN
Domain:
  • Contains 1 CSD (cold-shock) domain.:
    • Q9Y2V2
genes like me logo Genes that share domains with CARHSP1: view

No data available for Gene Families for CARHSP1 Gene

Function for CARHSP1 Gene

Molecular function for CARHSP1 Gene

UniProtKB/Swiss-Prot Function: Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).

Gene Ontology (GO) - Molecular Function for CARHSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003730 mRNA 3-UTR binding IDA 21078874
GO:0005515 protein binding IPI 25416956
GO:0019902 phosphatase binding NAS 12801884
genes like me logo Genes that share ontologies with CARHSP1: view

Phenotypes for CARHSP1 Gene

GenomeRNAi human phenotypes for CARHSP1:
genes like me logo Genes that share phenotypes with CARHSP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CARHSP1 Gene

Localization for CARHSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARHSP1 Gene

Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARHSP1 Gene COMPARTMENTS Subcellular localization image for CARHSP1 gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CARHSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000177 colocalizes_with cytoplasmic exosome (RNase complex) ISS --
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol ISS --
GO:0043186 P granule ISS --
genes like me logo Genes that share ontologies with CARHSP1: view

Pathways for CARHSP1 Gene

SuperPathways for CARHSP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CARHSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0035556 intracellular signal transduction TAS 9712905
GO:0043488 regulation of mRNA stability ISS --
genes like me logo Genes that share ontologies with CARHSP1: view

No data available for Pathways by source for CARHSP1 Gene

Transcripts for CARHSP1 Gene

Unigene Clusters for CARHSP1 Gene

Calcium regulated heat stable protein 1, 24kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARHSP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - - - - - - -
SP10: -
SP11: - - - - - - - - -
SP12:
SP13: - - - - - - - -

Relevant External Links for CARHSP1 Gene

GeneLoc Exon Structure for
CARHSP1
ECgene alternative splicing isoforms for
CARHSP1

Expression for CARHSP1 Gene

mRNA expression in normal human tissues for CARHSP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARHSP1 Gene

SOURCE GeneReport for Unigene cluster for CARHSP1 Gene Hs.632184

genes like me logo Genes that share expressions with CARHSP1: view

Orthologs for CARHSP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CARHSP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CARHSP1 36
  • 99.32 (n)
  • 100 (a)
CARHSP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CARHSP1 36
  • 87.41 (n)
  • 94.07 (a)
CARHSP1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARHSP1 36
  • 88.66 (n)
  • 96.6 (a)
CARHSP1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Carhsp1 36
  • 89.14 (n)
  • 97.04 (a)
Carhsp1 16
Carhsp1 37
  • 96 (a)
OneToMany
Gm9791 37
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 86 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CARHSP1 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Carhsp1 36
  • 88.21 (n)
  • 97.28 (a)
chicken
(Gallus gallus)
Aves CARHSP1 36
  • 77.53 (n)
  • 83.33 (a)
CARHSP1 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CARHSP1 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia carhsp1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia carhsp1 36
  • 72.18 (n)
  • 83.46 (a)
Str.15423 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10912 36
zebrafish
(Danio rerio)
Actinopterygii carhsp1 36
  • 70.34 (n)
  • 75.59 (a)
carhsp1 37
  • 66 (a)
OneToOne
zgc65920 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005641 36
  • 60.75 (n)
  • 64.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9705 36
  • 55.46 (n)
  • 56.03 (a)
CG9705 37
  • 49 (a)
OneToMany
Species with no ortholog for CARHSP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARHSP1 Gene

ENSEMBL:
Gene Tree for CARHSP1 (if available)
TreeFam:
Gene Tree for CARHSP1 (if available)

Paralogs for CARHSP1 Gene

Paralogs for CARHSP1 Gene

Selected SIMAP similar genes for CARHSP1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CARHSP1: view

Variants for CARHSP1 Gene

Sequence variations from dbSNP and Humsavar for CARHSP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs6484 -- 8,853,421(-) CGTTG(-/TGTTG)TTTCC utr-variant-3-prime
rs6898 -- 8,855,117(-) TTTGC(A/G)GGGAG utr-variant-3-prime
rs6899 -- 8,855,041(+) GATAC(G/T)TGAGA utr-variant-3-prime
rs8097 -- 8,859,224(+) TTGCC(C/G)CGCAG synonymous-codon, reference
rs9953 -- 8,853,271(+) TGGCT(G/T)TGGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CARHSP1 Gene

Variant ID Type Subtype PubMed ID
nsv457394 CNV Gain 19166990
dgv341n27 CNV Gain 19166990
dgv2598n71 CNV Gain 21882294
nsv905311 CNV Gain 21882294
nsv905320 CNV Gain 21882294
nsv521109 CNV Loss 19592680
esv27013 CNV Gain 19812545
nsv905321 CNV Gain 21882294
nsv833135 CNV Loss 17160897

Relevant External Links for CARHSP1 Gene

HapMap Linkage Disequilibrium report
CARHSP1

Disorders for CARHSP1 Gene

No disorders were found for CARHSP1 Gene.

No data available for UniProtKB/Swiss-Prot for CARHSP1 Gene

Publications for CARHSP1 Gene

  1. Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells. (PMID: 9712905) Groblewski G.E. … Williams J.A. (J. Biol. Chem. 1998) 2 3 4 23
  2. Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL. (PMID: 15910284) Auld G.C. … Cohen P. (Biochem. J. 2005) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response. (PMID: 21177848) Hou H. … Rao Z. (J. Biol. Chem. 2011) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CARHSP1 Gene

  • antibodies-online proteins for CARHSP1
  • antibodies-online antibodies for CARHSP1
  • antibodies-online kits for CARHSP1

Sources for CARHSP1 Gene

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