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Aliases for CARHSP1 Gene

Aliases for CARHSP1 Gene

  • Calcium Regulated Heat Stable Protein 1 2 3 5
  • Calcium-Regulated Heat-Stable Protein Of 24 KDa 3 4
  • Calcium Regulated Heat Stable Protein 1, 24kDa 2 3
  • CRHSP-24 3 4
  • Calcium Regulated Heat Stable Protein 1 (24kD) 2
  • Calcium-Regulated Heat-Stable Protein (24kD) 3
  • Calcium-Regulated Heat Stable Protein 1 3
  • Calcium-Regulated Heat-Stable Protein 1 3
  • CRHSP24 3
  • CSDC1 3

External Ids for CARHSP1 Gene

Previous GeneCards Identifiers for CARHSP1 Gene

  • GC16M008750
  • GC16M009048
  • GC16M008914
  • GC16M008916
  • GC16M008857
  • GC16M008946
  • GC16M008867

Summaries for CARHSP1 Gene

GeneCards Summary for CARHSP1 Gene

CARHSP1 (Calcium Regulated Heat Stable Protein 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and mRNA 3-UTR binding. An important paralog of this gene is CSDC2.

UniProtKB/Swiss-Prot for CARHSP1 Gene

  • Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).

Gene Wiki entry for CARHSP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARHSP1 Gene

Genomics for CARHSP1 Gene

Regulatory Elements for CARHSP1 Gene

Enhancers for CARHSP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G008858 1.7 Ensembl ENCODE dbSUPER 13.2 +4.5 4485 11.2 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ENSG00000260276 CARHSP1 PMM2 GC16P008857
GH16G008796 1.1 ENCODE 19 +71.0 70987 3.1 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A CARHSP1 ENSG00000260276 RNU7-63P PMM2 TMEM186 GC16M008818
GH16G008847 1.5 Ensembl ENCODE dbSUPER 12.9 +19.6 19556 3.5 PKNOX1 MLX ARID4B ZNF48 YY1 TCF12 ZNF121 FOS PAF1 SP5 ENSG00000260276 CARHSP1 PMM2 PIR52659 ENSG00000260350
GH16G008890 1.4 FANTOM5 ENCODE 13.8 -23.6 -23616 3.7 PKNOX1 FOXA2 MLX WRNIP1 SIN3A ARID4B DMAP1 YBX1 YY1 SLC30A9 CARHSP1 USP7 C16orf72 GC16P008905 LOC101929989
GH16G008841 0.8 Ensembl 20.3 +26.6 26628 0.8 GTF2F1 CTCF PKNOX1 ZNF384 ZNF644 RAD21 GATA3 CTBP1 POLR2A SCRT2 CARHSP1 ENSG00000260276 PMM2 GC16P008833 PIR57219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CARHSP1 on UCSC Golden Path with GeneCards custom track

Promoters for CARHSP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CARHSP1 Gene

8,852,942 bp from pter
8,869,012 bp from pter
16,071 bases
Minus strand

Genomic View for CARHSP1 Gene

Genes around CARHSP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARHSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARHSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARHSP1 Gene

Proteins for CARHSP1 Gene

  • Protein details for CARHSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-regulated heat-stable protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R4C3
    • D3DUF5
    • Q2YDX5
    • Q9BQ53

    Protein attributes for CARHSP1 Gene

    147 amino acids
    Molecular mass:
    15892 Da
    Quaternary structure:
    • Homodimer. Interacts with STYX (By similarity).

    Three dimensional structures from OCA and Proteopedia for CARHSP1 Gene

neXtProt entry for CARHSP1 Gene

Post-translational modifications for CARHSP1 Gene

  • Dephosphorylated by calcineurin in a Ca(2+) dependent manner (By similarity). Can be phosphorylated by DYRK2 (in vitro).
  • Ubiquitination at Lys64
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CARHSP1 Gene

Domains & Families for CARHSP1 Gene

Protein Domains for CARHSP1 Gene

Suggested Antigen Peptide Sequences for CARHSP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CARHSP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CARHSP1 Gene

Function for CARHSP1 Gene

Molecular function for CARHSP1 Gene

UniProtKB/Swiss-Prot Function:
Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).

Gene Ontology (GO) - Molecular Function for CARHSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0003730 mRNA 3-UTR binding IDA 21078874
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CARHSP1: view
genes like me logo Genes that share phenotypes with CARHSP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CARHSP1 Gene

Localization for CARHSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARHSP1 Gene

Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARHSP1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for CARHSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000177 colocalizes_with cytoplasmic exosome (RNase complex) ISS --
GO:0000932 P-body IEA --
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol ISS --
GO:0043186 P granule ISS --
genes like me logo Genes that share ontologies with CARHSP1: view

Pathways & Interactions for CARHSP1 Gene

SuperPathways for CARHSP1 Gene

No Data Available

SIGNOR curated interactions for CARHSP1 Gene

Other effect:

Gene Ontology (GO) - Biological Process for CARHSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0035556 intracellular signal transduction TAS 9712905
GO:0043488 regulation of mRNA stability IBA,ISS --
genes like me logo Genes that share ontologies with CARHSP1: view

No data available for Pathways by source for CARHSP1 Gene

Drugs & Compounds for CARHSP1 Gene

No Compound Related Data Available

Transcripts for CARHSP1 Gene

Unigene Clusters for CARHSP1 Gene

Calcium regulated heat stable protein 1, 24kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARHSP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - - - - - - -
SP10: -
SP11: - - - - - - - - -
SP13: - - - - - - - -

Relevant External Links for CARHSP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARHSP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CARHSP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CARHSP1 Gene

Protein tissue co-expression partners for CARHSP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CARHSP1 Gene:


SOURCE GeneReport for Unigene cluster for CARHSP1 Gene:


Evidence on tissue expression from TISSUES for CARHSP1 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Blood(4.2)
  • Eye(2.8)
genes like me logo Genes that share expression patterns with CARHSP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARHSP1 Gene

Orthologs for CARHSP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CARHSP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CARHSP1 34 35
  • 99.32 (n)
(Mus musculus)
Mammalia Gm9791 35
  • 95 (a)
Carhsp1 34 16 35
  • 89.14 (n)
(Canis familiaris)
Mammalia CARHSP1 34 35
  • 88.66 (n)
(Rattus norvegicus)
Mammalia Carhsp1 34
  • 88.21 (n)
(Bos Taurus)
Mammalia CARHSP1 34 35
  • 87.41 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 86 (a)
-- 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia CARHSP1 35
  • 70 (a)
(Gallus gallus)
Aves CARHSP1 34 35
  • 77.53 (n)
(Anolis carolinensis)
Reptilia CARHSP1 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia carhsp1 34
  • 72.18 (n)
Str.15423 34
African clawed frog
(Xenopus laevis)
Amphibia carhsp1-prov 34
(Danio rerio)
Actinopterygii carhsp1 34 35
  • 70.34 (n)
zgc65920 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10912 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005641 34
  • 60.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9705 34 35
  • 55.46 (n)
Species where no ortholog for CARHSP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARHSP1 Gene

Gene Tree for CARHSP1 (if available)
Gene Tree for CARHSP1 (if available)

Paralogs for CARHSP1 Gene

Paralogs for CARHSP1 Gene

(1) SIMAP similar genes for CARHSP1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CARHSP1: view

Variants for CARHSP1 Gene

Sequence variations from dbSNP and Humsavar for CARHSP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000037467 -- 8,869,291(+) TCCCT(A/G)CGCCC upstream-variant-2KB
rs1000247347 -- 8,853,685(+) CATAT(A/G)TTTCA utr-variant-3-prime
rs1000345225 -- 8,859,616(+) CACAA(A/C/G)GCATG intron-variant
rs1000425285 -- 8,864,159(+) TGCAC(-/AT)GTGTA intron-variant
rs1000518554 -- 8,868,370(+) GGCGC(G/T)GGTGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CARHSP1 Gene

Variant ID Type Subtype PubMed ID
dgv341n27 CNV gain 19166990
dgv4906n54 CNV gain 21841781
esv27013 CNV gain 19812545
esv2763129 CNV gain 21179565
nsv1036523 CNV gain 25217958
nsv1043528 CNV gain 25217958
nsv457394 CNV gain 19166990
nsv521109 CNV loss 19592680
nsv571424 CNV gain 21841781
nsv571428 CNV gain 21841781
nsv833135 CNV loss 17160897
nsv952916 CNV deletion 24416366

Variation tolerance for CARHSP1 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARHSP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARHSP1 Gene

Disorders for CARHSP1 Gene

Relevant External Links for CARHSP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CARHSP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARHSP1 Gene

Publications for CARHSP1 Gene

  1. Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells. (PMID: 9712905) Groblewski G.E. … Williams J.A. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL. (PMID: 15910284) Auld G.C. … Cohen P. (Biochem. J. 2005) 3 4 22 64
  3. Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response. (PMID: 21177848) Hou H. … Rao Z. (J. Biol. Chem. 2011) 3 4 64
  4. CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. (PMID: 21078874) Pfeiffer J.R. … Brooks S.A. (Mol. Cell. Biol. 2011) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for CARHSP1 Gene

Sources for CARHSP1 Gene

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