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CARD9 Gene

protein-coding   GIFtS: 57
GCID: GC09M139259

Caspase Recruitment Domain Family, Member 9

  See CARD9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caspase Recruitment Domain Family, Member 91 2
hCARD92 3
CANDF22 5
Caspase Recruitment Domain-Containing Protein 92

External Ids:    HGNC: 163911   Entrez Gene: 641702   Ensembl: ENSG000001877967   OMIM: 6072125   UniProtKB: Q9H2573   

Export aliases for CARD9 gene to outside databases

Previous GC identifers: GC09M130326 GC09M130947 GC09M132699 GC09M134615 GC09M136532 GC09M138373 GC09M138378 GC09M108717


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CARD9 Gene:
The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a
characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to
participate in activation or suppression of CARD containing members of the caspase family, and thus plays an
important regulatory role in cell apoptosis. This protein was identified by its selective association with the
CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a
molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively
spliced transcript variants have been observed, but their full-length nature is not clearly defined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CARD9 Gene:
CARD9 (caspase recruitment domain family, member 9) is a protein-coding gene. Diseases associated with CARD9 include deep dermatophytosis, and candidiasis, familial, 2, autosomal recessive. GO annotations related to this gene include protein homodimerization activity and CARD domain binding. An important paralog of this gene is CARD14.

UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
Function: Activates NF-kappa-B via BCL10

Gene Wiki entry for CARD9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CARD9 gene promoter:
         Pax-6   Nkx2-5   NRSF form 2   NF-kappaB   c-Ets-1   PPAR-gamma1   SEF-1 (1)   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CARD9 promoter sequence
   Search Chromatin IP Primers for CARD9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

CARD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD9 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139259:  view genomic region     (about GC identifiers)

Start:
139,256,355 bp from pter      End:
139,268,133 bp from pter
Size:
11,779 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257 (See protein sequence)
Recommended Name: Caspase recruitment domain-containing protein 9  
Size: 536 amino acids; 62241 Da
Subunit: Self-associates. CARD9 and BCL10 bind to each other by CARD-CARD interaction
Secondary accessions: Q5SXM5 Q5SXM6 Q9H854
Alternative splicing: 3 isoforms:  Q9H257-1   Q9H257-2   Q9H257-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CARD9: NX_Q9H257

Explore proteomics data for CARD9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CARD9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_434700.2  NP_434701.1  

    ENSEMBL proteins: 
     ENSP00000360799   ENSP00000360797   ENSP00000451368   ENSP00000323719  
    Reactome Protein details: Q9H257

    CARD9 Human Recombinant Protein Products:

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    Novus Biologicals CARD9 Proteins
    Novus Biologicals CARD9 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CARD9

     
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    antibodies-online proteins for CARD9 (7 products) 

     
    antibodies-online peptides for CARD9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q9H257

    ProtoNet protein and cluster: Q9H257

    1 Blocks protein domain: IPB001315 CARD interaction domain

    UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
    Similarity: Contains 1 CARD domain


    Find genes that share domains with CARD9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CARD9_HUMAN, Q9H257
    Function: Activates NF-kappa-B via BCL10

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IPI11053425
    GO:0050700CARD domain binding IPI11053425
         
    Find genes that share ontologies with CARD9           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CARD9:
     Decreased Wnt reporter activit  Decreased circadian period len  Increased viability after born 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Card9):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with CARD9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CARD9: Card9tm1Jrld Card9tm1Xlin Card9tm1Tks

       genOway: Develop your customized and physiologically relevant rodent model for CARD9

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CARD9_HUMAN, Q9H257: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11053425

    Find genes that share ontologies with CARD9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CARD9 About    
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68
    NOD pathway0.33
    2NOD-like Receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.58
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    3Tuberculosis
    Tuberculosis
    4NF-kappaB Signaling
    NF-kappaB Signaling


    Find genes that share SuperPaths with CARD9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CARD9
        NOD-like Receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for CARD9
        NF-kappaB Signaling

    1 BioSystems Pathway for CARD9
        NOD pathway

    1 Reactome Pathway for CARD9
        NOD1/2 Signaling Pathway


    2 Kegg Pathways  (Kegg details for CARD9):
        NOD-like receptor signaling pathway
    Tuberculosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CARD9: 
              Antiviral Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antifungal Response in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CARD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for CARD9 (Q9H2573 ENSP000003607974) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    RIPK2O433533, ENSP000002207514I2D: score=1 STRING: ENSP00000220751
    BCL10O959993I2D: score=4 
    KIAA0408Q6ZU523I2D: score=4 
    CSNK2A1P684003I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009620response to fungus IEA--
    GO:0032494response to peptidoglycan IEA--
    GO:0032495response to muramyl dipeptide IEA--
    GO:0032755positive regulation of interleukin-6 production IEA--
    GO:0032760positive regulation of tumor necrosis factor production IEA--

    Find genes that share ontologies with CARD9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CARD9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CARD9 gene (2 alternative transcripts): 
    NM_052813.4  NM_052814.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481053(uc011mdv.1 uc004chg.3) ENST00000460290 ENST00000371734(uc022bpo.1 uc022bpp.1 uc011mdx.1)
    ENST00000371732 ENST00000485975 ENST00000489932 ENST00000556340(uc010nbj.2)
    ENST00000315908
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      QuantiFast Probe-based Assays in human, mouse, rat CARD9

    Selected AceView cDNA sequences (see all 79):

    BM148244 CK429372 AI864569 NM_052813 AI364431 AI870963 AI283596 BI524042 
    BE326712 AI760335 AI656621 BU849125 CR603312 AI435052 AI803025 CD366678 
    AI580864 AI341906 AI620172 BX358484 BC070091 AI298841 AK024001 AI093587 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CARD9 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
    SP1:                                                                    -                       -                                                               
    SP2:                                                                    -           -           -                                                               
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CARD9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CARD9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTGTATTA
    CARD9 Expression
    About this image


    CARD9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
    CARD9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CARD9 Protein Expression

    UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
    Tissue specificity: Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood
    leukocytes and in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CARD9: 
              Antiviral Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antifungal Response in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CARD9 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Card91 , 5 caspase recruitment domain family, member 91, 5 84.55(n)1
    86.17(a)1
      2 (18.87 cM)5
    3325791  NM_001037747.11  NP_001032836.11 
     263521875 
    chicken
    (Gallus gallus)
    Aves CARD91 caspase recruitment domain family, member 9 67.48(n)
    61.24(a)
      427756  XM_425329.4  XP_425329.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia card91 caspase recruitment domain family, member 9 63.92(n)
    57.55(a)
      100145327  NM_001126802.1  NP_001120274.1 
    zebrafish
    (Danio rerio)
    Actinopterygii card91 caspase recruitment domain family, member 9 56.25(n)
    51.9(a)
      796425  NM_001110285.2  NP_001103755.1 


    ENSEMBL Gene Tree for CARD9 (if available)
    TreeFam Gene Tree for CARD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CARD9 gene
    CARD142  CARD102  CARD112  
    1 SIMAP similar gene for CARD9 using alignment to 1 protein entry:     CARD9_HUMAN:
    CARD10

    Find genes that share paralogs with CARD9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CARD9 (see all 387)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0708304
    Candidiasis, familial, 2 (CANDF2)4--see VAR_0708302 R P mis40--------
    VAR_0708294
    Candidiasis, familial, 2 (CANDF2)4--see VAR_0708292 R C mis40--------
    VAR_0708284
    Candidiasis, familial, 2 (CANDF2)4--see VAR_0708282 G S mis40--------
    rs2012692371,2
    C--139294519(+) CGTCC-/GCCC  
     TGCCCCG
    GCCCT
    2 -- int10--------
    rs1416649741,2
    C--139294531(+) CCCCG-/GCCCC 
            
    GCCCC
    2 -- int10--------
    rs1845360341,2
    --139294535(+) GGCCCC/TGCCCC 2 -- int10--------
    rs1501745141,2
    --139294547(+) CCGCCA/GTCTTG 2 -- int10--------
    rs11353141,2
    C,F,O,A,H--139294795(-) ATGCAT/CTGTAT 2 -- ut31 ese315Minor allele frequency- C:0.26MN NS EA NA WA CSA 973
    rs1886746881,2
    --139294992(+) CGACGG/TCTCGG 2 -- ut31 int10--------
    rs1510576241,2
    F--139295102(+) TCAGTG/ATCGGT 3 /D syn1 int11Minor allele frequency- A:0.00NA 3024

    HapMap Linkage Disequilibrium report for CARD9 (139256355 - 139268133 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CARD9 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509333CNV Insertion20534489
    dgv8393n71CNV Loss21882294
    nsv894294CNV Loss21882294
    nsv894361CNV Loss21882294
    dgv8390n71CNV Loss21882294
    nsv894359CNV Loss21882294
    dgv8389n71CNV Loss21882294
    dgv8386n71CNV Loss21882294
    nsv469918CNV Loss18288195
    nsv831760CNV Loss17160897

    Human Gene Mutation Database (HGMD): CARD9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CARD9
    DNA2.0 Custom Variant and Variant Library Synthesis for CARD9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607212   
    OMIM disorders: 212050  
    UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
  • Candidiasis, familial, 2 (CANDF2) [MIM:212050]: A primary immunodeficiency disorder with altered immune
    responses and impaired clearance of fungal infections, selective against Candida. It is characterized by
    persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus
    Candida, mainly Candida albicans. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 8 diseases for CARD9:    
    About MalaCards
    deep dermatophytosis    candidiasis, familial, 2, autosomal recessive    familial candidiasis 2    candidiasis
    dermatophytosis    sclerosing cholangitis    primary sclerosing cholangitis    ulcerative colitis

    2 diseases from the University of Copenhagen DISEASES database for CARD9:
    Candidiasis     Autoimmune polyendocrine syndrome

    Find genes that share disorders with CARD9           About GenesLikeMe

    Genetic Association Database (GAD): CARD9
    Human Genome Epidemiology (HuGE) Navigator: CARD9 (6 documents)

    Export disorders for CARD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CARD9 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CARD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B. (PubMed id 11053425)1, 2, 3 Bertin J.... Alnemri E.S. (J. Biol. Chem. 2000)
    2. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. (PubMed id 21743469)1, 4 Evans D.M.... . (Nat. Genet. 2011)
    3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    4. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Seielstad M. (Nat. Genet. 2010)
    5. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (Nat. Genet. 2010)
    6. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. (PubMed id 19915572)1, 4  ....Strachan D.P. (Nat. Genet. 2009)
    7. A homozygous CARD9 mutation in a family with susceptibility to fungal infections. (PubMed id 19864672)1, 2 Glocker E.-O.... Grimbacher B. (N. Engl. J. Med. 2009)
    8. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. (PubMed id 18439550)1, 4 Zhernakova A....Weersma R.K. (Am. J. Hum. Genet. 2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 64170 HGNC: 16391 AceView: CARD9 Ensembl:ENSG00000187796 euGenes: HUgn64170
    ECgene: CARD9 Kegg: 64170 H-InvDB: CARD9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CARD9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CARD9 gene:
    Search GeneIP for patents involving CARD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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