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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARD9 Gene

protein-coding   GIFtS: 61
GCID: GC09M139259

caspase recruitment domain family, member 9
 Explore 17 diseases affiliated with
CARD9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CARD9    

Aliases
for CARD9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Caspase Recruitment Domain Family, Member 91 2
HCARD91
CANDF22 5
Caspase Recruitment Domain-Containing Protein 92

External Ids:    HGNC: 163911   Entrez Gene: 641702   Ensembl: ENSG000001877967   OMIM: 6072125   UniProtKB: Q9H2573   

Export aliases for CARD9 gene to outside databases

Previous GC identifers: GC09M130326 GC09M130947 GC09M132699 GC09M134615 GC09M136532 GC09M138373 GC09M138378 GC09M108717


Summaries
for CARD9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CARD9:
The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a
characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate
in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory
role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a
postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the
assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have
been observed, but their full-length nature is not clearly defined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
Function: Activates NF-kappa-B via BCL10

Gene Wiki entry for CARD9


Genomic Views
for CARD9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_024000.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARD9 gene promoter:
         Pax-6   Nkx2-5   NRSF form 2   NF-kappaB   c-Ets-1   PPAR-gamma1   SEF-1 (1)   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CARD9 promoter sequence
   Search SABiosciences Chromatin IP Primers for CARD9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

CARD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD9 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139259:  view genomic region     (about GC identifiers)

Start:
 139,256,355 bp from pter      End:
 139,268,133 bp from pter
Size:
 11,779 bases      Orientation:
 minus strand

Proteins
for CARD9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257 (See protein sequence)
Recommended Name: Caspase recruitment domain-containing protein 9  
Size: 536 amino acids; 62241 Da
Subunit: Self-associates. CARD9 and BCL10 bind to each other by CARD-CARD interaction
Subcellular location: Cytoplasm
Secondary accessions: Q5SXM5 Q5SXM6 Q9H854
Alternative splicing: 3 isoforms:  Q9H257-1   Q9H257-2   Q9H257-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CARD9: NX_Q9H257

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H257

    • CARD9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_434700.2  NP_434701.1  

    ENSEMBL proteins: 
     ENSP00000360799   ENSP00000360797   ENSP00000451368   ENSP00000323719  
    Reactome Protein details: Q9H257
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): CARD9
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    Novus Biologicals CARD9 Proteins
    Novus Biologicals CARD9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CARD9

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11053425


    CARD9 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CARD9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CARD9 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q9H257

    ProtoNet protein and cluster: Q9H257

    1 Blocks protein family: IPB001315 CARD interaction domain

    UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
    Similarity: Contains 1 CARD domain


    Function
    for CARD9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
    Function: Activates NF-kappa-B via BCL10

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019904protein domain specific binding ----
    GO:0042803protein homodimerization activity IPI11053425
    GO:0050700CARD domain binding IPI11053425


    CARD9 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CARD9:
     Decreased Wnt reporter activit  Decreased circadian period len  Increased viability after born 

    Animal Models:
         Mouse knock-outs for CARD9: Card9tm1Jrld Card9tm1Xlin Card9tm1Tks
         2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Card9):
     homeostasis/metabolism  immune system 

    CARD9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CARD9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    		Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways1.00
    		NOD-like receptor signaling pathway0.36
    		NOD1/2 Signaling Pathway0.69
    		NOD pathway0.23
    2Immune System
    		Immune System1.00
    		Innate Immune System0.46
    3NF-kappaB Signaling
    		NF-kappaB Signaling1.00
    4Tuberculosis
    		Tuberculosis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CARD9
        NF-kappaB Signaling

    1 BioSystems Pathway for CARD9 
        NOD pathway

    4        Reactome Pathways for CARD9
        NOD1/2 Signaling Pathway
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Immune System
    Innate Immune System


    2         Kegg Pathways  (Kegg details for CARD9):
        NOD-like receptor signaling pathway
    Tuberculosis


    CARD9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CARD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/24 Interacting proteins for CARD9 (Q9H2573 ENSP000003607974) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    RIPK2O433533, ENSP000002207514I2D: score=1 STRING: ENSP00000220751
    BCL10O959993, ENSP000002710154I2D: score=4 STRING: ENSP00000271015
    KIAA0408Q6ZU523I2D: score=4 
    CSNK2A1P684003I2D: score=1 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007249I-kappaB kinase/NF-kappaB cascade ----
    GO:0009620response to fungus IEA--
    GO:0032494response to peptidoglycan IEA--
    GO:0032495response to muramyl dipeptide IEA--
    GO:0032755positive regulation of interleukin-6 production IEA--


    CARD9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CARD9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CARD9
    Search CenterWatch for drugs/clinical trials and news about CARD9 

    Transcripts
    for CARD9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CARD9 gene (2 alternative transcripts): 
    NM_052813.4  NM_052814.3  

    Unigene Cluster for CARD9:

    Caspase recruitment domain family, member 9
    Hs.694071  [show with all ESTs]
    Unigene Representative Sequence: NM_052813
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481053(uc011mdv.1 uc004chg.3) ENST00000460290 ENST00000371734(uc022bpo.1 uc022bpp.1 uc011mdx.1)
    ENST00000371732 ENST00000485975 ENST00000489932 ENST00000556340(uc010nbj.2)
    ENST00000315908

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF311287.1 AK292081.1 AK295647.1 AK309043.1 BC008877.2 

    7 DOTS entries:

    DT.100838039  DT.92419964  DT.97794263  DT.100744746  DT.99967841  DT.100743408  DT.99986904 

    24/79 AceView cDNA sequences (see all 79):

    AI341906 AI870963 AI435052 AI364431 BM148244 AI283596 AI803025 AI864569 
    AI656621 BU849125 AI580864 BE326712 CD366678 BI524042 CK429372 CR603312 
    AI760335 NM_052813 AI620172 AI494163 BC035805 BM562325 BF476454 BC070091 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CARD9 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
    SP1:                                                                    -                       -                                                               
    SP2:                                                                    -           -           -                                                               
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CARD9

    Expression
    for CARD9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CARD9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTGTATTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CARD9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CARD9

    SOURCE GeneReport for Unigene cluster: Hs.694071

    UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
    Tissue specificity: Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and
    in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including CARD9: 
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              Apoptosis 384HT in human mouse rat
              Antifungal Response in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CARD9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CARD9 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Card91 , 5 caspase recruitment domain family, member 91, 5 84.55(n)1
    86.17(a)1    		   2 (18.87 cM)5
    3325791  NM_001037747.11  NP_001032836.11 
     263521875 
    chicken
    (Gallus gallus)    		 Aves CARD91 caspase recruitment domain family, member 9 67.61(n)
    61.58(a)    		   427756  XM_425329.3  XP_425329.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii card91 caspase recruitment domain family, member 9 55.51(n)
    51.49(a)    		   796425  NM_001110285.1  NP_001103755.1 


    ENSEMBL Gene Tree for CARD9 (if available)
    TreeFam Gene Tree for CARD9 (if available) 

    Paralogs
    for CARD9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CARD9 gene
    CARD142  CARD112  CARD102  
    1 SIMAP similar gene for CARD9 using alignment to 1 protein entry:     CARD9_HUMAN:
    CARD10

    CARD9 for paralogs           About GeneDecksing



    Genomic Variants
    for CARD9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/242 NCBI SNPs in CARD9 are shown (see all 242)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2012692371,2
    		--139258186(+) CGTCC-/GCCC  
     TGCCCCG    GCCCT     		3 -- int1 ut510--------
    rs1416649741,2
    		--139258198(+) CCCCG-/GCCCC 
                GCCCC     		3 -- int1 ut510--------
    rs1845360341,2
    		--139258202(+) GGCCCC/TGCCCC 3 -- ut51 int10--------
    rs1501745141,2
    		--139258214(+) CCGCCA/GTCTTG 3 -- int1 ut510--------
    rs11353141,2
    		C,F,O,A,H,--139258462(-) ATGCAT/CTGTAT 3 -- us2k1 ut31 ese315Minor allele frequency- C:0.26MN NS EA NA WA CSA 973
    rs1886746881,2
    		--139258659(+) CGACGG/TCTCGG 3 -- us2k1 int1 ut310--------
    rs1510576241,2
    		F--139258769(+) TCAGTG/ATCGGT 4 /D us2k1 int1 syn11Minor allele frequency- A:0.00NA 3024
    rs1997470171,2
    		--139258775(+) TCGGTA/GTTGTC 4 N int1 syn1 us2k10--------
    rs1413104441,2
    		C,F--139258794(+) TGGTGT/GTCTCC 4 /N /T us2k1 mis1 int11Minor allele frequency- G:0.00NA 3266
    rs2018169321,2
    		--139258812(+) CCTCCC/TCCTGC 4 E G mis1 int1 us2k10--------

    HapMap Linkage Disequilibrium report for CARD9 (139256355 - 139268133 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for CARD9
         6 CNVs: 30353 3785 30350 30354 30355 0133
    Human Gene Mutation Database (HGMD): CARD9

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    Disorders / Diseases
    for CARD9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CARD9 for disorders           About GeneDecksing

    OMIM gene information: 607212   
    OMIM disorders: 212050  
    UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
  • Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2) [MIM:212050]. Chronic mucocutaneous
    • candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of
    the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous
    candidiasis

    17 diseases for CARD9:    About MalaCards
    candidiasis familial chronic mucocutaneous, autosomal recessive    plantar fasciitis    chronic mucocutaneous candidiasis    sclerosing cholangitis
    primary sclerosing cholangitis    autoimmune polyendocrine syndrome    candidiasis    job's syndrome
    cholangitis    ulcerative colitis    fasciitis    crohn's disease
    hepatitis b    hepatitis    cervicitis    tuberculosis
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for CARD9:
    Candidiasis     Autoimmune polyendocrine syndrome
    Human Genome Epidemiology (HuGE) Navigator: CARD9 (6 documents)

    Export disorders for CARD9 gene to outside databases

    Publications
    for CARD9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CARD9 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with CARD9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B. (PubMed id 11053425)1, 2, 3 Bertin J.... Alnemri E.S. (2000)
    2. A homozygous CARD9 mutation in a family with suscepti bility to fungal infections. (PubMed id 19864672)1, 2 Glocker E.O....Grimbacher B. (2009)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The autophagy regulator Rubicon is a feedback inhibito r of CARD9-mediated host innate immunity. (PubMed id 22423967)1 Yang C.S....Jung J.U. (2012)
    7. Human coronavirus-induced neuronal programmed cell de ath is cyclophilin d dependent and potentially caspase dispensable. (PubMed id 22013052)1 Favreau D.J....Talbot P.J. (2012)
    8. Changes in activities of caspase-8 and caspase-9 in h uman cervical malignancy. (PubMed id 21436691)1 Ekonomopoulou M.T....Iakovidou-Kritsi Z. (2011)
    9. Three ulcerative colitis susceptibility loci are asso ciated with primary sclerosing cholangitis and indicate a role for IL2, REL, an d CARD9. (PubMed id 21425313)1 Janse M....Weersma R.K. (2011)
    10. Genetic variation in the dectin-1/CARD9 recognition p athway and susceptibility to candidemia. (PubMed id 21881131)1 Rosentul D.C....Johnson M.D. (2011)

    External Searches for CARD9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CARD9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64170 HGNC: 16391 AceView: CARD9 Ensembl:ENSG00000187796 euGenes: HUgn64170
    ECgene: CARD9 Kegg: 64170 H-InvDB: CARD9

    Other Databases showing CARD9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CARD9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CARD9 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CARD9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CARD9 gene:
    Search GeneIP for patents involving CARD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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