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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARD9 Gene

protein-coding   GIFtS: 60
GCID: GC09M139259

Caspase Recruitment Domain Family, Member 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Caspase Recruitment Domain Family, Member 91 2
hCARD92 3
CANDF22 5
Caspase Recruitment Domain-Containing Protein 92

External Ids:    HGNC: 163911   Entrez Gene: 641702   Ensembl: ENSG000001877967   OMIM: 6072125   UniProtKB: Q9H2573   

Export aliases for CARD9 gene to outside databases

Previous GC identifers: GC09M130326 GC09M130947 GC09M132699 GC09M134615 GC09M136532 GC09M138373 GC09M138378 GC09M108717


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CARD9 Gene:
The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a
characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to
participate in activation or suppression of CARD containing members of the caspase family, and thus plays an
important regulatory role in cell apoptosis. This protein was identified by its selective association with the
CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a
molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively
spliced transcript variants have been observed, but their full-length nature is not clearly defined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CARD9 Gene: 
CARD9 (caspase recruitment domain family, member 9) is a protein-coding gene. Diseases associated with CARD9 include chronic mucocutaneous candidiasis, and job's syndrome, and among its related super-pathways are NOD1/2 Signaling Pathway and Immune System. GO annotations related to this gene include protein homodimerization activity and CARD domain binding. An important paralog of this gene is CARD14.

UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
Function: Activates NF-kappa-B via BCL10

Gene Wiki entry for CARD9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_024000.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARD9 gene promoter:
         Pax-6   Nkx2-5   NRSF form 2   NF-kappaB   c-Ets-1   PPAR-gamma1   SEF-1 (1)   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CARD9 promoter sequence
   Search SABiosciences Chromatin IP Primers for CARD9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

CARD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD9 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139259:  view genomic region     (about GC identifiers)

Start:
139,256,355 bp from pter      End:
139,268,133 bp from pter
Size:
11,779 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257 (See protein sequence)
Recommended Name: Caspase recruitment domain-containing protein 9  
Size: 536 amino acids; 62241 Da
Subunit: Self-associates. CARD9 and BCL10 bind to each other by CARD-CARD interaction
Subcellular location: Cytoplasm
Secondary accessions: Q5SXM5 Q5SXM6 Q9H854
Alternative splicing: 3 isoforms:  Q9H257-1   Q9H257-2   Q9H257-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CARD9: NX_Q9H257

Explore proteomics data for CARD9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H257

  • CARD9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CARD9 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_434700.2  NP_434701.1  

    ENSEMBL proteins: 
     ENSP00000360799   ENSP00000360797   ENSP00000451368   ENSP00000323719  
    Reactome Protein details: Q9H257
    Human Recombinant Protein Products for CARD9: 
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    Novus Biologicals CARD9 Proteins
    Novus Biologicals CARD9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CARD9 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11053425

    CARD9 for ontologies           About GeneDecksing



    CARD9 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for CARD9 
    Cloud-Clone Corp. CLIAs for CARD9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q9H257

    ProtoNet protein and cluster: Q9H257

    1 Blocks protein domain: IPB001315 CARD interaction domain

    UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
    Similarity: Contains 1 CARD domain


    CARD9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CARD9_HUMAN, Q9H257
    Function: Activates NF-kappa-B via BCL10

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IPI11053425
    GO:0050700CARD domain binding IPI11053425
         
    CARD9 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CARD9:
     Decreased Wnt reporter activit  Decreased circadian period len  Increased viability after born 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Card9):
     homeostasis/metabolism  immune system 

    CARD9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CARD9: Card9tm1Jrld Card9tm1Xlin Card9tm1Tks

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CARD9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CARD9

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARD9 

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CARD9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.69
    NOD pathway0.33
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Toll-Like receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.59
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    4Tuberculosis
    Tuberculosis
    5NF-kappaB Signaling
    NF-kappaB Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CARD9
        NOD-like Receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for CARD9
        NF-kappaB Signaling

    1 BioSystems Pathway for CARD9
        NOD pathway

    4        Reactome Pathways for CARD9
        NOD1/2 Signaling Pathway
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Immune System
    Innate Immune System


    2         Kegg Pathways  (Kegg details for CARD9):
        NOD-like receptor signaling pathway
    Tuberculosis


    CARD9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CARD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/25 Interacting proteins for CARD9 (Q9H2573 ENSP000003607974) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    RIPK2O433533, ENSP000002207514I2D: score=1 STRING: ENSP00000220751
    BCL10O959993I2D: score=4 
    KIAA0408Q6ZU523I2D: score=4 
    CSNK2A1P684003I2D: score=1 
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009620response to fungus IEA--
    GO:0032494response to peptidoglycan IEA--
    GO:0032495response to muramyl dipeptide IEA--
    GO:0032755positive regulation of interleukin-6 production IEA--
    GO:0032760positive regulation of tumor necrosis factor production IEA--

    CARD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CARD9

    Search CenterWatch for drugs/clinical trials and news about CARD9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CARD9 gene (2 alternative transcripts): 
    NM_052813.4  NM_052814.3  

    Unigene Cluster for CARD9:

    Caspase recruitment domain family, member 9
    Hs.694071  [show with all ESTs]
    Unigene Representative Sequence: NM_052813
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481053(uc011mdv.1 uc004chg.3) ENST00000460290 ENST00000371734(uc022bpo.1 uc022bpp.1 uc011mdx.1)
    ENST00000371732 ENST00000485975 ENST00000489932 ENST00000556340(uc010nbj.2)
    ENST00000315908
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CARD9 (NM_052813)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD9

    Additional mRNA sequence: 

    AF311287.1 AK292081.1 AK295647.1 AK309043.1 BC008877.2 

    7 DOTS entries:

    DT.100838039  DT.92419964  DT.97794263  DT.100744746  DT.99967841  DT.100743408  DT.99986904 

    24/79 AceView cDNA sequences (see all 79):

    AI864569 CR603312 NM_052813 CD366678 AI435052 BI524042 AI760335 AI803025 
    AI656621 BU849125 CK429372 AI364431 AI870963 BM148244 AI580864 AI283596 
    AI341906 BE326712 BC070091 AI298841 AK127481 AU142752 AU159990 AI620172 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CARD9 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
    SP1:                                                                    -                       -                                                               
    SP2:                                                                    -           -           -                                                               
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CARD9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CARD9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTGTATTA
    CARD9 Expression
    About this image


    See CARD9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CARD9

    SOURCE GeneReport for Unigene cluster: Hs.694071

    UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
    Tissue specificity: Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood
    leukocytes and in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including CARD9: 
              Antiviral Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antifungal Response in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CARD9 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Card91 , 5 caspase recruitment domain family, member 91, 5 84.55(n)1
    86.17(a)1
      2 (18.87 cM)5
    3325791  NM_001037747.11  NP_001032836.11 
     263521875 
    chicken
    (Gallus gallus)
    Aves CARD91 caspase recruitment domain family, member 9 67.61(n)
    61.58(a)
      427756  XM_425329.3  XP_425329.3 
    zebrafish
    (Danio rerio)
    Actinopterygii card91 caspase recruitment domain family, member 9 55.51(n)
    51.49(a)
      796425  NM_001110285.1  NP_001103755.1 


    ENSEMBL Gene Tree for CARD9 (if available)
    TreeFam Gene Tree for CARD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CARD9 gene
    CARD142  CARD102  CARD112  
    1 SIMAP similar gene for CARD9 using alignment to 1 protein entry:     CARD9_HUMAN:
    CARD10

    CARD9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/384 SNPs in CARD9 are shown (see all 384)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012692371,2
    C--139294519(+) CGTCC-/GCCC  
     TGCCCCG
    GCCCT
    2 -- int10--------
    rs1416649741,2
    C--139294531(+) CCCCG-/GCCCC 
            
    GCCCC
    2 -- int10--------
    rs1845360341,2
    --139294535(+) GGCCCC/TGCCCC 2 -- int10--------
    rs1501745141,2
    --139294547(+) CCGCCA/GTCTTG 2 -- int10--------
    rs11353141,2
    C,F,O,A,H--139294795(-) ATGCAT/CTGTAT 2 -- ut31 ese315Minor allele frequency- C:0.26MN NS EA NA WA CSA 973
    rs1886746881,2
    --139294992(+) CGACGG/TCTCGG 2 -- ut31 int10--------
    rs1510576241,2
    F--139295102(+) TCAGTG/ATCGGT 3 /D syn1 int11Minor allele frequency- A:0.00NA 3024
    rs1997470171,2
    --139295108(+) TCGGTA/GTTGTC 3 N syn1 int10--------
    rs1413104441,2
    C,F--139295127(+) TGGTGT/GTCTCC 3 /N /T mis1 int11Minor allele frequency- G:0.00NA 3266
    rs2018169321,2
    --139295145(+) CCTCCC/TCCTGC 3 E G mis1 int10--------

    HapMap Linkage Disequilibrium report for CARD9 (139256355 - 139268133 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for CARD9 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509333CNV Insertion20534489
    dgv8393n71CNV Loss21882294
    nsv894294CNV Loss21882294
    nsv894361CNV Loss21882294
    dgv8390n71CNV Loss21882294
    nsv894359CNV Loss21882294
    dgv8389n71CNV Loss21882294
    dgv8386n71CNV Loss21882294
    nsv469918CNV Loss18288195
    nsv831760CNV Loss17160897


    Human Gene Mutation Database (HGMD): CARD9
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CARD9
    DNA2.0 Custom Variant and Variant Library Synthesis for CARD9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607212   
    OMIM disorders: 212050  
    UniProtKB/Swiss-Prot: CARD9_HUMAN, Q9H257
  • Familial candidiasis 2 (CANDF2) [MIM:212050]: A primary immunodeficiency disorder with altered immune
    responses and impaired clearance of fungal infections, selective against Candida. It is characterized by
    persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus
    Candida, mainly Candida albicans. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 18 diseases for CARD9:    About MalaCards
    chronic mucocutaneous candidiasis    job's syndrome    familial candidiasis 2    plantar fasciitis
    candidiasis familial chronic mucocutaneous, autosomal recessive    fasciitis    candidiasis    primary sclerosing cholangitis
    sclerosing cholangitis    autoimmune polyendocrine syndrome    ulcerative colitis    cholangitis
    crohn's disease    hepatitis b    hepatitis    cervicitis
    tuberculosis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for CARD9:
    Candidiasis     Autoimmune polyendocrine syndrome

    CARD9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CARD9
    Human Genome Epidemiology (HuGE) Navigator: CARD9 (6 documents)

    Export disorders for CARD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CARD9 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with CARD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B. (PubMed id 11053425)1, 2, 3 Bertin J.... Alnemri E.S. (2000)
    2. Interaction between ERAP1 and HLA-B27 in ankylosing sp ondylitis implicates peptide handling in the mechanism for HLA-B27 in disease su sceptibility. (PubMed id 21743469)1, 4 Evans D.M.... . (2011)
    3. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (2011)
    4. Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Weersma R.K. (2010)
    5. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (2010)
    6. Genome-wide association study of ulcerative colitis i dentifies three new susceptibility loci, including the HNF4A region. (PubMed id 19915572)1, 4  .... D.P. (2009)
    7. A homozygous CARD9 mutation in a family with suscepti bility to fungal infections. (PubMed id 19864672)1, 2 Glocker E.O....Grimbacher B. (2009)
    8. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. (PubMed id 18439550)1, 4 Zhernakova A....Weersma R.K. (2008)
    9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64170 HGNC: 16391 AceView: CARD9 Ensembl:ENSG00000187796 euGenes: HUgn64170
    ECgene: CARD9 Kegg: 64170 H-InvDB: CARD9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CARD9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CARD9 gene:
    Search GeneIP for patents involving CARD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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