CARD8 Gene
protein-coding GIFtS: 57
GCID: GC19M048711
|
|
caspase recruitment domain family, member 8
| |
Aliases
for CARD8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Caspase Recruitment Domain Family, Member 81 2 | | DACAR2 3 | | TUCAN1 2 3 5 | | Dakar1 | | CARDINAL1 2 3 | | DAKAR2 | | KIAA09551 3 5 | | CARD Inhibitor Of NF-KappaB-Activating Ligands2 | | NDPP12 3 5 | | Caspase Recruitment Domain-Containing Protein 82 | | NDPP1 2 | | Tumor Up-Regulated CARD-Containing Antagonist Of Caspase Nine2 | | Apoptotic Protein NDPP12 3 | | CARD-Inhibitor Of NF-Kappa-B-Activating Ligand3 | | Tumor Up-Regulated CARD-Containing Antagonist Of CASP92 3 | | |
Export aliases for CARD8 gene to outside databasesPrevious GC identifers: GC19M053403 GC19M052918 GC19M045093 |
Summaries
for CARD8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CARD8:
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, whichare involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be acomponent of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. Itis thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependentIL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoidarthritis. Alternatively spliced transcript variants have been described for this gene. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: CARD8_HUMAN, Q9Y2G2Function: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responsescontrolled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which alsoincludes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases
Gene Wiki entry for CARD8
|
Genomic Views
for CARD8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CARD8 gene promoter:
Tal-1 ITF-2 Tal-1beta E47 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CARD8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33CARD8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M048711: view genomic region
(about GC identifiers)
Start:
|
48,706,403 bp from pter |
End:
|
48,759,203 bp from pter |
Size:
|
52,801 bases |
Orientation:
|
minus strand |
|
Proteins
for CARD8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CARD8_HUMAN, Q9Y2G2 (See
protein sequence)Recommended Name: Caspase recruitment domain-containing protein 8 Size: 431 amino acids; 48933 Da
Subunit: May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG.Interacts with FNBP3 (By similarity). Interacts with NALP2 NACHT domain
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=BAA76799.2; Type=Erroneous initiation;
Secondary accessions: B5KVR6 B7Z496 B7Z4A2 E9PEM7 G3XAM9 Q6PGP8 Q96P82Alternative splicing: 5 isoforms: Q9Y2G2-1 Q9Y2G2-2 Q9Y2G2-3 Q9Y2G2-4 Q9Y2G2-5 (Ref.6 (ABW96891) sequence is in conflict in positions: 84:D->G, 107:E->D)Explore the universe of human proteins at neXtProt for CARD8: NX_Q9Y2G2
CARD8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001171829.1 NP_001171830.1 NP_001171831.1 NP_001171832.1 NP_001171833.1 NP_055774.2
ENSEMBL proteins: ENSP00000428975 ENSP00000428662 ENSP00000430057 ENSP00000430495 ENSP00000429839 ENSP00000429362 ENSP00000428736 ENSP00000430836 ENSP00000430747 ENSP00000427858 ENSP00000428862 ENSP00000428883 ENSP00000430460 ENSP00000429741 ENSP00000428740 ENSP00000430567 ENSP00000427922 ENSP00000430108 ENSP00000427727 ENSP00000430178 ENSP00000350423 ENSP00000391248 ENSP00000375767 ENSP00000351901
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CARD8 for ontologies About GeneDecksing
CARD8 Antibody Products:
Assay Products for CARD8: |
Protein
Domains /
Families
for CARD8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CARD8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2G2ProtoNet protein and cluster: Q9Y2G2 UniProtKB/Swiss-Prot: CARD8_HUMAN, Q9Y2G2Similarity: Contains 1 CARD domain |
Function
for CARD8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CARD8_HUMAN, Q9Y2G2Function: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responsescontrolled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which alsoincludes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD8 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD8 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): CARD8 (NM_001184900) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CARD8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD8 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CARD8 for ontologies About GeneDecksing
|
Pathways & Interactions
for CARD8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for CARD8
1 
Kegg Pathway (Kegg details for CARD8):
CARD8 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CARD8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/12 Interacting proteins for CARD8 (Q9Y2G22, 3 ENSP000003519014) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
IDA | 15030775 | | GO:0042981 | regulation of apoptotic process |
-- | -- | | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB cascade |
IDA | 11551959 | | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
IDA | 15030775 | | GO:0050718 | positive regulation of interleukin-1 beta secretion |
IDA | 15030775 |
CARD8 for ontologies About GeneDecksing
|
Drugs & Compounds
for CARD8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CARD8
Search CenterWatch for drugs/clinical trials and news about CARD8
|
Transcripts
for CARD8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CARD8 gene (6 alternative transcripts): NM_001184900.1 NM_001184901.1 NM_001184902.1 NM_001184903.1 NM_001184904.1 NM_014959.3 Unigene Clusters for CARD8: Caspase recruitment domain family, member 8 Hs.446146 [show with all ESTs], Hs.655940 [show with all ESTs]Unigene Representative Sequences: NM_001184902, AF14386918/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31): ENST00000518450(uc002pid.1) ENST00000517510(uc010xzi.1) ENST00000518622
ENST00000377461 ENST00000518979 ENST00000520753 ENST00000522773 ENST00000520153
ENST00000522051 ENST00000519646 ENST00000520015 ENST00000521613 ENST00000521415
ENST00000519940 ENST00000523579 ENST00000519302 ENST00000523668 ENST00000522068
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD8 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD8 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): CARD8 (NM_001184900) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CARD8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD8 |
Additional cDNA sequence: AF143869.1 24/28 DOTS entries (see all 28): DT.451902 DT.92429337 DT.91665985 DT.100022324 DT.202699 DT.100022325 DT.440717 DT.92429335 DT.97803839 DT.121502196 DT.121502202 DT.92429336 DT.92429338 DT.121502193 DT.121502200 DT.86852063 DT.95204562 DT.100796423 DT.91752779 DT.95213833 DT.121502163 DT.40130633 DT.92429332 DT.95309096 24/175 AceView cDNA sequences (see all 175): AA480189 AA747715 AI811472 AF331519 AW069306 BQ008766 BM146318 AI653168 AI968421 BC041697 AF511652 AL702642 AA282618 CA449810 AA371310 AA326546 AY026322 AL549614 AA721184 BQ072850 BM678686 BM722104 CR625326 AA282531
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CARD8 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17b | · | 17c | · | 17d | · | 17e | · | 17f |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for CARD8
|
Expression
for CARD8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CARD8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAGATGGA
About this image
See CARD8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CARD8
SOURCE GeneReport for Unigene clusters: Hs.446146 Hs.655940
UniProtKB/Swiss-Prot: CARD8_HUMAN, Q9Y2G2Tissue specificity: High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver.Also expressed in spleen, lymph node and bone marrow
SABiosciences Custom PCR Arrays for CARD8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD8
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CARD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD8 |
Orthologs
for CARD8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CARD8 gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4169981 |
caspase recruitment domain-containing protein 8-like |
50.95(n)
36.93(a) |
|
416998 XM_415289.3 XP_415289.3 |
ENSEMBL Gene Tree for CARD8 (if available)
TreeFam Gene Tree for CARD8 (if available) |
Paralogs
for CARD8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CARD8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CARD8 (48706403 - 48759203 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CARD8
3 CNVs: 47965 50186 32261
1 Inversion: 59751
Human Gene Mutation Database (HGMD): CARD8
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD8 |
|
Disorders
/ Diseases
for CARD8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CARD8 for disorders About GeneDecksing
OMIM gene information: 609051
OMIM disorders: --
18  diseases for CARD8: About MalaCardsrheumatoid arthritis masters-allen syndrome arthritis inflammatory bowel disease
rheumatoid arthritis, association with chronic lymphocytic leukemia intrahepatic cholangiocarcinoma lymphocytic leukemia
renal cell carcinoma crohn's disease cholangiocarcinoma alzheimer's disease
colorectal cancer leukemia lung cancer esophagitis
adenocarcinoma carcinoma
1 disease from the University of Copenhagen DISEASES database for CARD8:Masters-Allen syndrome 4 Novoseek disease relationships for CARD8 gene About this table
Human Genome Epidemiology (HuGE) Navigator: CARD8 (18 documents)
Export disorders for CARD8 gene to outside databases
|
Publications
for CARD8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CARD8 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with CARD8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. (PubMed id 11408476)1, 2, 3, 9 Pathan N....Reed J.C. (2001)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
- CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PubMed id 11821383)1, 2, 9 Razmara M.... Alnemri E.S. (2002)
- Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation. (PubMed id 18212821)1, 2, 9 Bagnall R.D....Mathew C.G. (2008)
- NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. (PubMed id 15030775)1, 2 Agostini L....Tschopp J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation. (PubMed id 11956601)1, 2 Zhang H. and Fu W. (2002)
- TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation. (PubMed id 12067710)1, 2 Stilo R.... Liguoro D. (2002)
- CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. (PubMed id 11551959)1, 2 Bouchier-Hayes L.... Martin S.J. (2001)
- Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases? (PubMed id 18311798)1, 9 Verma D....Sarndahl E. (2008)
|
External Searches for CARD8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CARD8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CARD8 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CARD8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CARD8 gene:
Search GeneIP for patents involving CARD8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CARD8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for CARD8 | | OriGene shRNA RFP for CARD8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD8 | | | OriGene Protein Over-expression Lysate for CARD8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CARD8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CARD8 | | OriGene Custom Protein Services for CARD8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CARD8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD8 |
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| | | | Search Tocris compounds for CARD8 |
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 | | | CARD8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD8 |
|  |  |  | | | | ThermoFisher Antibody for CARD8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD8 |
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