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CARD8 Gene

protein-coding   GIFtS: 61
GCID: GC19M048711

Caspase Recruitment Domain Family, Member 8

  See CARD8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caspase Recruitment Domain Family, Member 81 2     KIAA09553 5
NDPP12 3 5     DAKAR2
TUCAN2 3 5     NDPP2
Apoptotic Protein NDPP12 3     CARD Inhibitor Of NF-KappaB-Activating Ligands2
Tumor Up-Regulated CARD-Containing Antagonist Of CASP92 3     Caspase Recruitment Domain-Containing Protein 82
CARDINAL2 3     Tumor Up-Regulated CARD-Containing Antagonist Of Caspase Nine2
DACAR2 3     CARD-Inhibitor Of NF-Kappa-B-Activating Ligand3

External Ids:    HGNC: 170571   Entrez Gene: 229002   Ensembl: ENSG000001054837   OMIM: 6090515   UniProtKB: Q9Y2G23   

Export aliases for CARD8 gene to outside databases

Previous GC identifers: GC19M053403 GC19M052918 GC19M045093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CARD8 Gene:
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins,
which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein
may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory
caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation,
CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility
to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. (provided
by RefSeq, May 2010)

GeneCards Summary for CARD8 Gene:
CARD8 (caspase recruitment domain family, member 8) is a protein-coding gene. Diseases associated with CARD8 include masters-allen syndrome, and rheumatoid arthritis. GO annotations related to this gene include NACHT domain binding and protein homodimerization activity. An important paralog of this gene is NLRC5.

UniProtKB/Swiss-Prot: CARD8_HUMAN, Q9Y2G2
Function: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular
responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein
complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory
caspases

Gene Wiki entry for CARD8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CARD8 gene promoter:
         Tal-1   ITF-2   Tal-1beta   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CARD8 promoter sequence
   Search Chromatin IP Primers for CARD8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARD8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

CARD8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M048711:  view genomic region     (about GC identifiers)

Start:
48,684,027 bp from pter      End:
48,759,203 bp from pter
Size:
75,177 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CARD8_HUMAN, Q9Y2G2 (See protein sequence)
Recommended Name: Caspase recruitment domain-containing protein 8  
Size: 431 amino acids; 48933 Da
Subunit: May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and
CARD18/ICEBERG. Interacts with FNBP3 (By similarity). Interacts with NALP2 NACHT domain
Sequence caution: Sequence=BAA76799.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CARD8:
4IKM (3D)    
Secondary accessions: B5KVR6 B7Z496 B7Z4A2 E9PEM7 G3XAM9 Q6PGP8 Q96P82
Alternative splicing: 5 isoforms:  Q9Y2G2-1   Q9Y2G2-2   Q9Y2G2-3   Q9Y2G2-4   Q9Y2G2-5   (Ref.6 (ABW96891) sequence is in conflict in positions: 84:D->G, 107:E->D)

Explore the universe of human proteins at neXtProt for CARD8: NX_Q9Y2G2

Explore proteomics data for CARD8 at MOPED


See CARD8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts): 
NP_001171829.1  NP_001171830.1  NP_001171831.1  NP_001171832.1  NP_001171833.1  NP_055774.2  

ENSEMBL proteins: 
 ENSP00000428975   ENSP00000428662   ENSP00000430057   ENSP00000430495   ENSP00000429839  
 ENSP00000429362   ENSP00000428736   ENSP00000430836   ENSP00000430747   ENSP00000427858  
 ENSP00000428862   ENSP00000428883   ENSP00000430460   ENSP00000429741   ENSP00000430567  
 ENSP00000427922   ENSP00000430108   ENSP00000427727   ENSP00000430178   ENSP00000350423  
 ENSP00000391248   ENSP00000375767   ENSP00000351901  

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antibodies-online proteins for CARD8 (8 products) 

 
antibodies-online peptides for CARD8

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR011029 DEATH-like_dom
 IPR001315 CARD
 IPR025307 FIIND_dom

Graphical View of Domain Structure for InterPro Entry Q9Y2G2

ProtoNet protein and cluster: Q9Y2G2

UniProtKB/Swiss-Prot: CARD8_HUMAN, Q9Y2G2
Similarity: Contains 1 CARD domain


Find genes that share domains with CARD8           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CARD8_HUMAN, Q9Y2G2
Function: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular
responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein
complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory
caspases

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI11551959
GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process IDA15030775
GO:0032089NACHT domain binding IPI15030775
GO:0042803protein homodimerization activity IDA15030775
     
Find genes that share ontologies with CARD8           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CARD8

miRNA
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miRTarBase miRNAs that target CARD8:
hsa-mir-16-5p (MIRT000824), hsa-mir-15a-5p (MIRT000825), hsa-mir-375 (MIRT019890)

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CARD8_HUMAN, Q9Y2G2: Cytoplasm. Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol3
mitochondrion3

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IDA--
GO:0005730NOT nucleolus IDA--
GO:0005737cytoplasm IDA--
GO:0072559NLRP3 inflammasome complex IDA15030775

Find genes that share ontologies with CARD8           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CARD8 About    
See pathways by source

SuperPathContained pathways About
1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
NOD-like receptor signaling pathway0.37
NOD pathway0.33


Find genes that share SuperPaths with CARD8           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for CARD8
    NOD pathway


1 Kegg Pathway  (Kegg details for CARD8):
    NOD-like receptor signaling pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CARD8
Interactions:

    GeneGlobe Interaction Network for CARD8

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for CARD8 (Q9Y2G22, 3 ENSP000003519014) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
InteractantInteraction Details
GeneCardExternal ID(s)
FHL2Q141922, 3, ENSP000003229094MINT-18623 MINT-18622 I2D: score=2 STRING: ENSP00000322909
CASP9P552112, 3, ENSP000003302374MINT-17223 I2D: score=2 STRING: ENSP00000330237
IKBKGQ9Y6K92, 3, ENSP000003586224MINT-17746 I2D: score=3 STRING: ENSP00000358622
CARD16Q5EG053, ENSP000003648584I2D: score=1 STRING: ENSP00000364858
CASP1P294663, ENSP000004100764I2D: score=2 STRING: ENSP00000410076
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA15030775
GO:0042981regulation of apoptotic process ----
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling IDA11551959
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA15030775
GO:0050718positive regulation of interleukin-1 beta secretion IDA15030775

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CARD8



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CARD8 gene (6 alternative transcripts): 
NM_001184900.1  NM_001184901.1  NM_001184902.1  NM_001184903.1  NM_001184904.1  NM_014959.3  

Unigene Clusters for CARD8:

Caspase recruitment domain family, member 8
Hs.446146  [show with all ESTs], Hs.655940  [show with all ESTs]
Unigene Representative Sequences: NM_001184902, AF143869
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
ENST00000600800 ENST00000518450(uc002pid.1) ENST00000517510(uc010xzi.1)
ENST00000518622 ENST00000377461 ENST00000518979 ENST00000520753 ENST00000522773
ENST00000520153 ENST00000522051 ENST00000519646 ENST00000520015 ENST00000521613
ENST00000521415 ENST00000519940 ENST00000523579 ENST00000519302 ENST00000523668

miRNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD8
Primer
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OriGene qPCR primer pairs and template standards for CARD8
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  QuantiFast Probe-based Assays in human, mouse, rat CARD8

Additional mRNA sequence: AF143869.1 

Selected DOTS entries (see all 28):

DT.451902  DT.92429337  DT.91665985  DT.100022324  DT.202699  DT.100022325  DT.440717  DT.92429335 
DT.97803839  DT.121502196  DT.121502202  DT.92429336  DT.92429338  DT.121502193  DT.121502200  DT.86852063 
DT.95204562  DT.100796423  DT.91752779  DT.95213833  DT.121502163  DT.40130633  DT.92429332  DT.95309096 

Selected AceView cDNA sequences (see all 175):

AL549614 AL702642 AA371310 AY026322 AW069306 BM146318 AF331519 AI653168 
CR625326 BC041697 AA480189 AA282531 AA747715 AI968421 AW572672 BQ008766 
BM722104 AI811472 AA721184 BQ072850 BM678686 CA449810 AA282618 AA326546 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CARD8 (see all 12)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1:                          -     -     -                                         -                                               -                           
SP2:                                                                                -                                               -                           
SP3:                                                                          -     -                                               -                           
SP4:                                                                          -     -                                               -           -               
SP5:                          -     -     -                 -                 -     -                                                                           

ExUns: 17b · 17c · 17d · 17e · 17f
SP1:                              
SP2:                              
SP3:                              
SP4:                              
SP5:                              


ECgene alternative splicing isoforms for CARD8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CARD8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCAGATGGA
CARD8 Expression
About this image


CARD8 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
 
 Liver (Hepatobiliary System)
         Hepatocytes Liver Lobule
 
 Blood (Hematopoietic System)
         Granulocytes Peripheral Blood
CARD8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CARD8 Protein Expression

SOURCE GeneReport for Unigene clusters: Hs.446146 Hs.655940

UniProtKB/Swiss-Prot: CARD8_HUMAN, Q9Y2G2
Tissue specificity: High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and
liver. Also expressed in spleen, lymph node and bone marrow

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CARD8 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia CARD86
caspase recruitment domain family, member 8
72(a)
1 ↔ 1
1(108049615-108060603)
chicken
(Gallus gallus)
Aves CARD86
caspase recruitment domain family, member 8
32(a)
1 ↔ 1
15(10027879-10036555)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
3(a)
many ↔ many
GL343281.1(870024-877915)
zebrafish
(Danio rerio)
Actinopterygii NLRP16
NLR family, pyrin domain containing 1
5(a)
1 → many
7(76802107-76814306) ENSDARG00000044796


ENSEMBL Gene Tree for CARD8 (if available)
TreeFam Gene Tree for CARD8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CARD8 gene
NLRC52  NOD22  NLRX12  NLRP12  NOD12  CIITA2  
3 SIMAP similar genes for CARD8 using alignment to 15 protein entries:     CARD8_HUMAN (see all proteins):
DKFZp686B22249    NLRP1    GYPB

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CARD8 (see all 1309)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1114248271,2
C--45093336(+) ACCTA-/T/TT  
        
TTTTT
16 -- ut31 nc-transcript-variant1CSA 2
rs347028411,2
C,F--45094044(+) TTTTT-/A/TAAAAA 16 -- ut31 nc-transcript-variant2NA CSA 4
rs1120312151,2
C--45101353(+) CTATC-/A/AA  
        
AAAAA
8 -- int11CSA 2
rs343930281,2
C--45101909(+) GTGGA-/GGAAGG 8 -- int11Minor allele frequency- G:0.00NA 2
rs1414416581,2
C--45102831(+) TGCAA-/ATGTT 
        
ATGTT
8 -- int10--------
rs1380805371,2
C--45106171(+) AAAGG-/AAAAGG 8 -- int10--------
rs360294071,2
C--45124696(+) CAGAC-/TTTTTT 9 -- int12Minor allele frequency- T:0.25NA CSA 4
rs30781961,2
C--45131843(-) TTTTT-/T/TT  
        
ATTAT
7 -- int11CSA 2
rs1132106201,2
C,F--48718219(+) TTTTTG/ATATTT 8 -- int14Minor allele frequency- A:0.33WA CSA 123
rs38424151,2
C--48720876(+) TGTTA-/ATGT  
 T
/TGTTA
ATATC
8 -- int11NA 2

HapMap Linkage Disequilibrium report for CARD8 (48684027 - 48759203 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CARD8 (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
esv2669487CNV Deletion23128226
nsv458716CNV Loss19166990
nsv912218CNV Loss21882294
nsv523716CNV Loss19592680
nsv833854CNV Loss17160897
nsv458717CNV Loss19166990
esv34181CNV Loss18971310
nsv9739CNV Gain+Loss18304495
nsv517364CNV Gain+Loss19592680
nsv469623CNV Complex16826518

Human Gene Mutation Database (HGMD): CARD8
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CARD8
DNA2.0 Custom Variant and Variant Library Synthesis for CARD8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609051    OMIM disorders: --

2 diseases for CARD8:    
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masters-allen syndrome    rheumatoid arthritis

1 disease from the University of Copenhagen DISEASES database for CARD8:
Masters-Allen syndrome

Find genes that share disorders with CARD8           About GenesLikeMe

4 Novoseek inferred disease relationships for CARD8 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
colon cancer 31.7 3 16204039 (1), 11408476 (1)
inflammation 0.544 1 18212821 (1)
tumors 0 3 16204039 (1), 11408476 (1)
cancer 0 3 11408476 (2), 16204039 (1)

Genetic Association Database (GAD): CARD8
Human Genome Epidemiology (HuGE) Navigator: CARD8 (18 documents)

Export disorders for CARD8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CARD8 gene, integrated from 10 sources (see all 55):
(articles sorted by number of sources associating them with CARD8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. (PubMed id 11408476)1, 2, 3, 9 Pathan N....Reed J.C. (J. Biol. Chem. 2001)
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
  3. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PubMed id 11821383)1, 2, 9 Razmara M.... Alnemri E.S. (J. Biol. Chem. 2002)
  4. Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation. (PubMed id 18212821)1, 2, 9 Bagnall R.D....Mathew C.G. (Eur. J. Hum. Genet. 2008)
  5. Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases? (PubMed id 18311798)1, 4, 9 Verma D....SAorndahl E. (Arthritis Rheum. 2008)
  6. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). (PubMed id 18263599)1, 4, 9 Kastbom A....SAPderkvist P. (Rheumatology (Oxford) 2008)
  7. The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces. (PubMed id 23695559)1, 2 Jin T.... Xiao T.S. (Acta Crystallogr. F 2013)
  8. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
  9. CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis. (PubMed id 19443463)1, 4 Kastbom A....RantapAoAo-Dahlqvist S. (Ann. Rheum. Dis. 2010)
  10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 22900 HGNC: 17057 AceView: CARD8 Ensembl:ENSG00000105483 euGenes: HUgn22900
ECgene: CARD8 Kegg: 22900 H-InvDB: CARD8

(According to HUGE)
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HUGE: KIAA0955

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CARD8 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CARD8 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CARD8 gene:
Search GeneIP for patents involving CARD8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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