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Aliases for CARD8 Gene

Aliases for CARD8 Gene

  • Caspase Recruitment Domain Family, Member 8 2 3
  • NDPP1 3 4 6
  • TUCAN 3 4 6
  • Tumor Up-Regulated CARD-Containing Antagonist Of CASP9 3 4
  • Apoptotic Protein NDPP1 3 4
  • CARDINAL 3 4
  • KIAA0955 4 6
  • DACAR 3 4
  • Tumor Up-Regulated CARD-Containing Antagonist Of Caspase Nine 3
  • Caspase Recruitment Domain-Containing Protein 8 3
  • CARD Inhibitor Of NF-KappaB-Activating Ligands 3
  • CARD-Inhibitor Of NF-Kappa-B-Activating Ligand 4
  • DAKAR 3
  • NDPP 3

External Ids for CARD8 Gene

Previous GeneCards Identifiers for CARD8 Gene

  • GC19M053403
  • GC19M052918
  • GC19M048711
  • GC19M045093

Summaries for CARD8 Gene

Entrez Gene Summary for CARD8 Gene

  • The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for CARD8 Gene

CARD8 (Caspase Recruitment Domain Family, Member 8) is a Protein Coding gene. Diseases associated with CARD8 include masters-allen syndrome and rheumatoid arthritis. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include protein homodimerization activity and NACHT domain binding. An important paralog of this gene is NLRX1.

UniProtKB/Swiss-Prot for CARD8 Gene

  • Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases

Gene Wiki entry for CARD8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD8 Gene

Genomics for CARD8 Gene

Regulatory Elements for CARD8 Gene

Genomic Location for CARD8 Gene

Start:
48,180,770 bp from pter
End:
48,255,946 bp from pter
Size:
75,177 bases
Orientation:
Minus strand

Genomic View for CARD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD8 Gene

Proteins for CARD8 Gene

  • Protein details for CARD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G2-CARD8_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 8
    Protein Accession:
    Q9Y2G2
    Secondary Accessions:
    • B5KVR6
    • B7Z496
    • B7Z4A2
    • E9PEM7
    • G3XAM9
    • Q6PGP8
    • Q96P82

    Protein attributes for CARD8 Gene

    Size:
    431 amino acids
    Molecular mass:
    48933 Da
    Quaternary structure:
    • May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG. Interacts with FNBP3 (By similarity). Interacts with NALP2 NACHT domain.
    SequenceCaution:
    • Sequence=BAA76799.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CARD8 Gene

    Alternative splice isoforms for CARD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARD8 Gene

Proteomics data for CARD8 Gene at MOPED

Post-translational modifications for CARD8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CARD8 Gene

Domains for CARD8 Gene

Protein Domains for CARD8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y2G2

UniProtKB/Swiss-Prot:

CARD8_HUMAN :
  • Q9Y2G2
Domain:
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with CARD8: view

No data available for Gene Families for CARD8 Gene

Function for CARD8 Gene

Molecular function for CARD8 Gene

UniProtKB/Swiss-Prot Function: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases

Gene Ontology (GO) - Molecular Function for CARD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11551959
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA 15030775
GO:0032089 NACHT domain binding IPI 15030775
GO:0042803 protein homodimerization activity IDA 15030775
genes like me logo Genes that share ontologies with CARD8: view

Animal Model Products

CRISPR Products

miRNA for CARD8 Gene

miRTarBase miRNAs that target CARD8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CARD8 Gene

Localization for CARD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARD8 Gene COMPARTMENTS Subcellular localization image for CARD8 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 3

Gene Ontology (GO) - Cellular Components for CARD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11551959
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0072559 NLRP3 inflammasome complex IDA 15030775
genes like me logo Genes that share ontologies with CARD8: view

Pathways for CARD8 Gene

genes like me logo Genes that share pathways with CARD8: view

Pathways by source for CARD8 Gene

1 BioSystems pathway for CARD8 Gene
1 KEGG pathway for CARD8 Gene

Gene Ontology (GO) - Biological Process for CARD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 15030775
GO:0042981 regulation of apoptotic process --
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA 11551959
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 15030775
GO:0050718 positive regulation of interleukin-1 beta secretion IDA 15030775
genes like me logo Genes that share ontologies with CARD8: view

Transcripts for CARD8 Gene

Unigene Clusters for CARD8 Gene

Caspase recruitment domain family, member 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CARD8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD8 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - - -
SP8:
SP9: - - - - - - - - -
SP10: - - -
SP11:
SP12: - -

ExUns: 17b · 17c · 17d · 17e · 17f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CARD8 Gene

GeneLoc Exon Structure for
CARD8
ECgene alternative splicing isoforms for
CARD8

Expression for CARD8 Gene

mRNA expression in normal human tissues for CARD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CARD8 Gene

This gene is overexpressed in Whole Blood (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARD8 Gene

SOURCE GeneReport for Unigene cluster for CARD8 Gene Hs.446146

mRNA Expression by UniProt/SwissProt for CARD8 Gene

Q9Y2G2-CARD8_HUMAN
Tissue specificity: High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow
genes like me logo Genes that share expressions with CARD8: view

In Situ Assay Products

Orthologs for CARD8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CARD8 35
  • 97 (n)
  • 94.89 (a)
CARD8 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARD8 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CARD8 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 3 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii NLRP1 36
  • 5 (a)
OneToMany
Species with no ortholog for CARD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD8 Gene

ENSEMBL:
Gene Tree for CARD8 (if available)
TreeFam:
Gene Tree for CARD8 (if available)

Paralogs for CARD8 Gene

Paralogs for CARD8 Gene

genes like me logo Genes that share paralogs with CARD8: view

Variants for CARD8 Gene

Sequence variations from dbSNP and Humsavar for CARD8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs274864 -- 48,230,005(+) ctact(C/T)aagag intron-variant
rs1062806 -- 48,210,188(-) AGCTT(A/C)CGTAT utr-variant-3-prime, nc-transcript-variant
rs1064791 -- 48,218,212(-) AAATT(A/T)AAAAA intron-variant
rs1125297 -- 48,246,607(+) AATAG(A/G)AAATC intron-variant
rs1127769 -- 48,249,801(-) AAGCA(A/G)CAAGC utr-variant-5-prime, upstream-variant-2KB, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CARD8 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
esv34181 CNV Loss 18971310
nsv523716 CNV Loss 19592680
nsv912218 CNV Loss 21882294
nsv458716 CNV Loss 19166990
nsv469623 CNV Complex 16826518
esv8882 OTHER Inversion 19470904
nsv458717 CNV Loss 19166990
nsv517364 CNV Gain+Loss 19592680
esv2669487 CNV Deletion 23128226
nsv833854 CNV Loss 17160897

Relevant External Links for CARD8 Gene

HapMap Linkage Disequilibrium report
CARD8
Human Gene Mutation Database (HGMD)
CARD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD8 Gene

Disorders for CARD8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CARD8 Gene including...

Search for CARD8 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CARD8 Gene

(4) Novoseek inferred disease relationships for CARD8 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 31.7 2
inflammation 0.544 1
tumors 0 2
cancer 0 3

Relevant External Links for CARD8

Genetic Association Database (GAD)
CARD8
Human Genome Epidemiology (HuGE) Navigator
CARD8
genes like me logo Genes that share disorders with CARD8: view

No data available for UniProtKB/Swiss-Prot for CARD8 Gene

Publications for CARD8 Gene

  1. TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. (PMID: 11408476) Pathan N. … Reed J.C. (J. Biol. Chem. 2001) 2 3 4 23
  2. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PMID: 11821383) Razmara M. … Alnemri E.S. (J. Biol. Chem. 2002) 3 4 23
  3. Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation. (PMID: 18212821) Bagnall R.D. … Mathew C.G. (Eur. J. Hum. Genet. 2008) 3 4 23
  4. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). (PMID: 18263599) Kastbom A. … SAPderkvist P. (Rheumatology (Oxford) 2008) 3 23 48
  5. Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases? (PMID: 18311798) Verma D. … SAorndahl E. (Arthritis Rheum. 2008) 3 23 48

Products for CARD8 Gene

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