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CARD6 Gene

protein-coding   GIFtS: 53
GCID: GC05P040841

Caspase Recruitment Domain Family, Member 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caspase Recruitment Domain Family, Member 61 2
CINCIN12 5
CARD-Containing Inhibitor Of Nod1 And Cardiak-Induced NF-KB Activation2
Caspase Recruitment Domain Protein 62
Caspase Recruitment Domain-Containing Protein 62

External Ids:    HGNC: 163941   Entrez Gene: 846742   Ensembl: ENSG000001323577   OMIM: 6099865   UniProtKB: Q9BX693   

Export aliases for CARD6 gene to outside databases

Previous GC identifers: GC05P041147 GC05P041933 GC05P040886 GC05P040877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CARD6 Gene:
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle
that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein
that has been shown to interact with receptor-interacting protein kinases and positively modulate signal
transduction pathways converging on activation of the inducible transcription factor NF-kB. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CARD6 Gene:
CARD6 (caspase recruitment domain family, member 6) is a protein-coding gene. An important paralog of this gene is URGCP.

UniProtKB/Swiss-Prot: CARD6_HUMAN, Q9BX69
Function: May be involved in apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CARD6 gene promoter:
         Nkx3-1   Nkx3-1 v4   XBP-1   Nkx3-1 v1   E47   Nkx3-1 v2   HSF2   Nkx3-1 v3   ZID   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCARD6 promoter sequence
   Search Chromatin IP Primers for CARD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.1

CARD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P040841:  view genomic region     (about GC identifiers)

Start:
40,841,286 bp from pter      End:
40,860,275 bp from pter
Size:
18,990 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CARD6_HUMAN, Q9BX69 (See protein sequence)
Recommended Name: Caspase recruitment domain-containing protein 6  
Size: 1037 amino acids; 116468 Da
Secondary accessions: Q52LR2

Explore the universe of human proteins at neXtProt for CARD6: NX_Q9BX69

Explore proteomics data for CARD6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys307
  • Modification sites at PhosphoSitePlus

  • See CARD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115976.2  
    ENSEMBL proteins: 
     ENSP00000254691   ENSP00000371093  

    CARD6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for CARD6
    Search eBioscience for ELISAs for CARD6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q9BX69

    ProtoNet protein and cluster: Q9BX69

    1 Blocks protein domain: IPB001315 CARD interaction domain

    UniProtKB/Swiss-Prot: CARD6_HUMAN, Q9BX69
    Similarity: Contains 1 CARD domain


    Find genes that share domains with CARD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CARD6_HUMAN, Q9BX69
    Function: May be involved in apoptosis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CARD6           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Card6):
     immune system  no phenotypic analysis 

    Find genes that share phenotypes with CARD6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Card6tm1.1Aldu for CARD6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CARD6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CARD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CARD6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARD6

    miRNA
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    Block miRNA regulation of human, mouse, rat CARD6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CARD6:
    hsa-miR-515-5p hsa-miR-767-3p hsa-miR-590-3p hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidCARD6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CARD6

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    Find genes that share ontologies with CARD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CARD6 About    
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33


    Find genes that share SuperPaths with CARD6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CARD6
        NOD pathway


    1 Kegg Pathway  (Kegg details for CARD6):
        NOD-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CARD6: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CARD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CARD6 (Q9BX693 ENSP000002546914) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK2O433533, ENSP000002207514I2D: score=3 STRING: ENSP00000220751
    CARD8Q9Y2G23, ENSP000003519014I2D: score=2 STRING: ENSP00000351901
    NLRP1Q9C0003, ENSP000002692804I2D: score=1 STRING: ENSP00000269280
    NOD1Q9Y2393, ENSP000002228234I2D: score=3 STRING: ENSP00000222823
    RIPK1Q135463I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0042981regulation of apoptotic process IEA--

    Find genes that share ontologies with CARD6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CARD6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CARD6 gene: 
    NM_032587.3  

    Unigene Cluster for CARD6:

    Caspase recruitment domain family, member 6
    Hs.200242  [show with all ESTs]
    Unigene Representative Sequence: AF356193
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254691(uc003jmg.3) ENST00000381677
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CARD6:
    hsa-miR-515-5p hsa-miR-767-3p hsa-miR-590-3p hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidCARD6 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CARD6
      QuantiFast Probe-based Assays in human, mouse, rat CARD6

    Additional mRNA sequence: 

    AB209844.1 AF356193.1 AK304349.1 BC093825.1 

    2 DOTS entries:

    DT.95075872  DT.120813827 

    Selected AceView cDNA sequences (see all 26):

    BF000142 CK430149 CA443032 AY196783 BQ380079 BE552385 NM_032587 BX475234 
    AF356193 AW613437 BE504923 BP366769 BF591169 BI771142 AW192194 CD695148 
    AA302352 BE737100 BF749423 CD634164 BQ773339 AW196663 R87651 R84288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CARD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCAGCAA
    CARD6 Expression
    About this image


    CARD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Brain (Nervous System)
             Cerebellum
    CARD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CARD6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.200242
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CARD6: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CARD6 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Card61 , 5 caspase recruitment domain family, member 61, 5 70.92(n)1
    58.71(a)1
      15 (1.99 cM)5
    2393191  NM_001163138.11  NP_001156610.11 
     50959815 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-204a24.106
    si:dkey-202l22.66
    (see all 4)
    si:dkey-202l22.6
    (see all 4)
    9(a)
    8(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    19(8304645-8313511) ENSDARG00000036767
    15(12365809-12372271) ENSDARG00000097717


    ENSEMBL Gene Tree for CARD6 (if available)
    TreeFam Gene Tree for CARD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CARD6 gene
    URGCP2  
    1 SIMAP similar gene for CARD6 using alignment to 2 protein entries:     CARD6_HUMAN (see all proteins):
    CINCIN1

    Find genes that share paralogs with CARD6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CARD6 (see all 392)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1435150991,2
    --40784010(+) GCCATA/TCTTTT 1 -- us2k10--------
    rs1480271951,2
    --40784083(+) GTTGCA/GGGGAA 1 -- us2k10--------
    rs10704441,2
    C,F,A,H--40784223(-) ATATAG/ATTATG 1 -- us2k115Minor allele frequency- A:0.08NS EA NA 2202
    rs1461049611,2
    C--40784267(+) TAAAA-/CTCTTCA 1 -- us2k10--------
    rs339411261,2
    C--40784311(+) TAATA-/TCATAT 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs1164538451,2
    C,F--40784417(+) AAGCAG/CCTGGG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs785570711,2
    C,F--40784433(+) AGATGC/TGCACC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1460190231,2
    --40784505(+) TGGCCC/TCAAAC 1 -- us2k10--------
    rs1893531891,2
    --40784687(+) TTTACA/GTATTA 1 -- us2k10--------
    rs1399689931,2
    --40784742(+) CTACAC/TTGTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CARD6 (40841286 - 40860275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CARD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673909CNV Deletion23128226
    esv2730121CNV Deletion23290073
    esv2665245CNV Deletion23128226
    nsv880438CNV Loss21882294
    nsv820142CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609986    OMIM disorders: --


    Find genes that share disorders with CARD6           About GenesLikeMe

    Genetic Association Database (GAD): CARD6

    Export disorders for CARD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CARD6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CARD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak- mediated pathways. (PubMed id 12775719)1, 3, 9 Stehlik C.... Reed J.C. (J. Biol. Chem. 2003)
    2. Expression of CARD6, an NF-kappaB activator, in gastric, colorectal and oesophageal cancers. (PubMed id 20025480)1, 9 Kim S.S....Lee S.H. (Pathology 2010)
    3. Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. (PubMed id 16418290)1, 9 Dufner A....Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    4. CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. (PubMed id 16582588)1, 9 Dufner A. and Mak T.W. (Cell Cycle 2006)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84674 HGNC: 16394 AceView: CARD6 Ensembl:ENSG00000132357 euGenes: HUgn84674
    ECgene: CARD6 Kegg: 84674 H-InvDB: CARD6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CARD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CARD6 gene:
    Search GeneIP for patents involving CARD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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