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Aliases for CARD6 Gene

Aliases for CARD6 Gene

  • Caspase Recruitment Domain Family, Member 6 2 3
  • CINCIN1 3 6
  • CARD-Containing Inhibitor Of Nod1 And Cardiak-Induced NF-KB Activation 3
  • Caspase Recruitment Domain-Containing Protein 6 3
  • Caspase Recruitment Domain Protein 6 3

External Ids for CARD6 Gene

Summaries for CARD6 Gene

Entrez Gene Summary for CARD6 Gene

  • This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]

GeneCards Summary for CARD6 Gene

CARD6 (Caspase Recruitment Domain Family, Member 6) is a Protein Coding gene. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. An important paralog of this gene is URGCP.

UniProtKB/Swiss-Prot for CARD6 Gene

  • May be involved in apoptosis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD6 Gene

Genomics for CARD6 Gene

Genomic Location for CARD6 Gene

Start:
40,841,184 bp from pter
End:
40,860,175 bp from pter
Size:
18,992 bases
Orientation:
Plus strand

Genomic View for CARD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD6 Gene

Regulatory Elements for CARD6 Gene

Proteins for CARD6 Gene

  • Protein details for CARD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX69-CARD6_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 6
    Protein Accession:
    Q9BX69
    Secondary Accessions:
    • Q52LR2

    Protein attributes for CARD6 Gene

    Size:
    1037 amino acids
    Molecular mass:
    116468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CARD6 Gene

Proteomics data for CARD6 Gene at MOPED

Post-translational modifications for CARD6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys307

Other Protein References for CARD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CARD6 Gene

Domains for CARD6 Gene

Protein Domains for CARD6 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CARD6_HUMAN
Domain:
  • Contains 1 CARD domain.:
    • Q9BX69
genes like me logo Genes that share domains with CARD6: view

No data available for Gene Families for CARD6 Gene

Function for CARD6 Gene

Molecular function for CARD6 Gene

UniProtKB/Swiss-Prot Function: May be involved in apoptosis

Phenotypes for CARD6 Gene

genes like me logo Genes that share phenotypes with CARD6: view

Animal Models for CARD6 Gene

MGI Knock Outs for CARD6:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for CARD6 Gene

Localization for CARD6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARD6 Gene COMPARTMENTS Subcellular localization image for CARD6 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for CARD6 Gene

Pathways for CARD6 Gene

genes like me logo Genes that share pathways with CARD6: view

Pathways by source for CARD6 Gene

1 BioSystems pathway for CARD6 Gene
1 KEGG pathway for CARD6 Gene

Gene Ontology (GO) - Biological Process for CARD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CARD6: view

Transcripts for CARD6 Gene

mRNA/cDNA for CARD6 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARD6 Gene

Caspase recruitment domain family, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARD6 Gene

No ASD Table

Relevant External Links for CARD6 Gene

GeneLoc Exon Structure for
CARD6
ECgene alternative splicing isoforms for
CARD6

Expression for CARD6 Gene

mRNA expression in normal human tissues for CARD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CARD6 Gene

This gene is overexpressed in Whole Blood (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARD6 Gene

SOURCE GeneReport for Unigene cluster for CARD6 Gene Hs.200242

genes like me logo Genes that share expressions with CARD6: view

Orthologs for CARD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CARD6 36
  • 99.2 (n)
  • 98.26 (a)
CARD6 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CARD6 36
  • 81.43 (n)
  • 69.72 (a)
CARD6 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CARD6 36
  • 80.41 (n)
  • 70.66 (a)
CARD6 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Card6 36
  • 70.92 (n)
  • 58.71 (a)
Card6 16
Card6 37
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CARD6 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 2 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Card6 36
  • 70.84 (n)
  • 59.02 (a)
zebrafish
(Danio rerio)
Actinopterygii BX005336.3 37
  • 11 (a)
ManyToMany
si:dkey-202l22.6 37
  • 8 (a)
ManyToMany
si:dkey-204a24.10 37
  • 9 (a)
ManyToMany
si:dkey-204a24.11 37
  • 10 (a)
ManyToMany
Species with no ortholog for CARD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD6 Gene

ENSEMBL:
Gene Tree for CARD6 (if available)
TreeFam:
Gene Tree for CARD6 (if available)

Paralogs for CARD6 Gene

Paralogs for CARD6 Gene

Selected SIMAP similar genes for CARD6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CARD6: view

Variants for CARD6 Gene

Sequence variations from dbSNP and Humsavar for CARD6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs173969 -- 40,841,854(-) CAGTA(A/G)ACCAA intron-variant
rs187274 -- 40,840,885(-) ccgaa(G/T)atgta upstream-variant-2KB
rs188934 -- 40,852,349(-) CTAGC(C/G)GTCAC synonymous-codon, reference
rs192962 -- 40,850,763(-) AAATA(C/T)TCTAG intron-variant
rs323562 - 40,853,058(-) TTCAA(C/T)GGCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CARD6 Gene

Variant ID Type Subtype PubMed ID
nsv880438 CNV Loss 21882294
nsv820142 CNV Loss 19587683
esv2665245 CNV Deletion 23128226
esv2673909 CNV Deletion 23128226
esv2730121 CNV Deletion 23290073

Relevant External Links for CARD6 Gene

HapMap Linkage Disequilibrium report
CARD6

Disorders for CARD6 Gene

Relevant External Links for CARD6

Genetic Association Database (GAD)
CARD6
genes like me logo Genes that share disorders with CARD6: view

No data available for UniProtKB/Swiss-Prot for CARD6 Gene

Publications for CARD6 Gene

  1. CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak- mediated pathways. (PMID: 12775719) Stehlik C. … Reed J.C. (J. Biol. Chem. 2003) 2 3 23
  2. Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. (PMID: 16418290) Dufner A. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  3. CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. (PMID: 16582588) Dufner A. … Mak T.W. (Cell Cycle 2006) 3 23
  4. Expression of CARD6, an NF-kappaB activator, in gastric, colorectal and oesophageal cancers. (PMID: 20025480) Kim S.S. … Lee S.H. (Pathology 2010) 3 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CARD6 Gene

Sources for CARD6 Gene

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