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Aliases for CARD6 Gene

Aliases for CARD6 Gene

  • Caspase Recruitment Domain Family Member 6 2 3 5
  • CARD-Containing Inhibitor Of Nod1 And Cardiak-Induced NF-KB Activation 3
  • Caspase Recruitment Domain-Containing Protein 6 3
  • Caspase Recruitment Domain Family, Member 6 2
  • Caspase Recruitment Domain Protein 6 3
  • CINCIN1 3

External Ids for CARD6 Gene

Previous GeneCards Identifiers for CARD6 Gene

  • GC05P041147
  • GC05P041933
  • GC05P040841
  • GC05P040886

Summaries for CARD6 Gene

Entrez Gene Summary for CARD6 Gene

  • This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]

GeneCards Summary for CARD6 Gene

CARD6 (Caspase Recruitment Domain Family Member 6) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways and NOD pathway. An important paralog of this gene is URGCP.

UniProtKB/Swiss-Prot for CARD6 Gene

  • May be involved in apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD6 Gene

Genomics for CARD6 Gene

Regulatory Elements for CARD6 Gene

Enhancers for CARD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F040840 0.5 ENCODE 22.7 +0.7 651 2.0 PKNOX1 ARNT FEZF1 ZNF2 YY1 ZNF766 FOS ZNF263 CREB3 MAFF CARD6 PRKAA1 PLCXD3 C7
GH05F040671 1.4 FANTOM5 Ensembl ENCODE 19.3 -168.4 -168384 2.4 IKZF1 SPI1 CARD6 PRKAA1 PTGER4 LOC105374738 ENSG00000199552
GH05F040832 1 ENCODE 18.5 -6.7 -6706 4.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PRKAA1 CARD6 PLCXD3 TTC33 GC05M040833 RPL37 SNORD72
GH05F040783 0.8 Ensembl ENCODE 18.2 -56.4 -56448 2.5 ELF3 MLX ARID4B RAD21 ZSCAN9 RARA YY1 GATA4 CREM MIXL1 CARD6 TTC33 SNORD72 RPL37 ENSG00000212567 GC05M040791
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CARD6 on UCSC Golden Path with GeneCards custom track

Promoters for CARD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001278938 816 2001 PKNOX1 ARNT FEZF1 ZNF2 YY1 ZNF766 FOS ZNF263 CREB3 MAFF

Genomic Location for CARD6 Gene

40,841,184 bp from pter
40,860,175 bp from pter
18,992 bases
Plus strand

Genomic View for CARD6 Gene

Genes around CARD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD6 Gene

Proteins for CARD6 Gene

  • Protein details for CARD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caspase recruitment domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q52LR2

    Protein attributes for CARD6 Gene

    1037 amino acids
    Molecular mass:
    116468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CARD6 Gene

Post-translational modifications for CARD6 Gene

  • Ubiquitination at Lys 307
  • Modification sites at PhosphoSitePlus

Other Protein References for CARD6 Gene

No data available for DME Specific Peptides for CARD6 Gene

Domains & Families for CARD6 Gene

Gene Families for CARD6 Gene

Protein Domains for CARD6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CARD domain.
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with CARD6: view

Function for CARD6 Gene

Molecular function for CARD6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in apoptosis.
genes like me logo Genes that share phenotypes with CARD6: view

Animal Models for CARD6 Gene

MGI Knock Outs for CARD6:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARD6 Gene

Localization for CARD6 Gene

Subcellular locations from

Jensen Localization Image for CARD6 Gene COMPARTMENTS Subcellular localization image for CARD6 gene
Compartment Confidence
cytosol 4
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CARD6 Gene

Pathways & Interactions for CARD6 Gene

genes like me logo Genes that share pathways with CARD6: view

Pathways by source for CARD6 Gene

1 BioSystems pathway for CARD6 Gene
1 KEGG pathway for CARD6 Gene

Gene Ontology (GO) - Biological Process for CARD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CARD6: view

No data available for SIGNOR curated interactions for CARD6 Gene

Transcripts for CARD6 Gene

mRNA/cDNA for CARD6 Gene

Unigene Clusters for CARD6 Gene

Caspase recruitment domain family, member 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD6 Gene

No ASD Table

Relevant External Links for CARD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARD6 Gene

mRNA expression in normal human tissues for CARD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CARD6 Gene

This gene is overexpressed in Whole Blood (x9.4).

Protein differential expression in normal tissues from HIPED for CARD6 Gene

This gene is overexpressed in Blymphocyte (30.9), Peripheral blood mononuclear cells (22.5), and Tlymphocyte (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CARD6 Gene

Protein tissue co-expression partners for CARD6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CARD6 Gene:


SOURCE GeneReport for Unigene cluster for CARD6 Gene:

genes like me logo Genes that share expression patterns with CARD6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CARD6 Gene

Orthologs for CARD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CARD6 34 35
  • 99.2 (n)
(Bos Taurus)
Mammalia CARD6 34 35
  • 81.43 (n)
(Canis familiaris)
Mammalia CARD6 34 35
  • 80.41 (n)
(Mus musculus)
Mammalia Card6 34 16 35
  • 70.92 (n)
(Rattus norvegicus)
Mammalia Card6 34
  • 70.84 (n)
(Monodelphis domestica)
Mammalia CARD6 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 2 (a)
(Danio rerio)
Actinopterygii BX005336.3 35
  • 11 (a)
si:dkey-204a24.11 35
  • 10 (a)
si:dkey-204a24.10 35
  • 9 (a)
si:dkey-202l22.6 35
  • 8 (a)
Species where no ortholog for CARD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD6 Gene

Gene Tree for CARD6 (if available)
Gene Tree for CARD6 (if available)

Paralogs for CARD6 Gene

Paralogs for CARD6 Gene

(1) SIMAP similar genes for CARD6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CARD6: view

Variants for CARD6 Gene

Sequence variations from dbSNP and Humsavar for CARD6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10045776 -- 40,850,555(+) aaaat(A/C)caaaa intron-variant
rs10050965 -- 40,854,772(+) tttag(A/C/T)agagg utr-variant-3-prime
rs10052625 -- 40,855,043(+) GGGGG(C/T)CTATG utr-variant-3-prime
rs10059556 -- 40,854,953(+) ATGAA(A/G)ATAAT utr-variant-3-prime
rs10064650 -- 40,840,119(+) atatg(C/T)gaggt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CARD6 Gene

Variant ID Type Subtype PubMed ID
esv2665245 CNV deletion 23128226
esv2673909 CNV deletion 23128226
esv2730121 CNV deletion 23290073
nsv597877 CNV gain 21841781
nsv820142 CNV loss 19587683

Variation tolerance for CARD6 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD6 Gene

Disorders for CARD6 Gene

Relevant External Links for CARD6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CARD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD6 Gene

Publications for CARD6 Gene

  1. CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak- mediated pathways. (PMID: 12775719) Stehlik C. … Reed J.C. (J. Biol. Chem. 2003) 2 3 22 64
  2. Expression of CARD6, an NF-kappaB activator, in gastric, colorectal and oesophageal cancers. (PMID: 20025480) Kim S.S. … Lee S.H. (Pathology 2010) 3 22 64
  3. Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. (PMID: 16418290) Dufner A. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 22 64
  4. CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. (PMID: 16582588) Dufner A. … Mak T.W. (Cell Cycle 2006) 3 22 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for CARD6 Gene

Sources for CARD6 Gene

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