CARD6 Gene
protein-coding GIFtS: 51
GCID: GC05P040877
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|
caspase recruitment domain family, member 6
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Aliases
for CARD6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Caspase Recruitment Domain Family, Member 61 2 | | CINCIN11 2 5 | | CARD-Containing Inhibitor Of Nod1 And Cardiak-Induced NF-KB Activation2 | | Caspase Recruitment Domain Protein 62 | | Caspase Recruitment Domain-Containing Protein 62 |
Export aliases for CARD6 gene to outside databasesPrevious GC identifers: GC05P041147 GC05P041933 GC05P040841 GC05P040886 |
Summaries
for CARD6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CARD6:
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle thatmediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has beenshown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathwaysconverging on activation of the inducible transcription factor NF-kB. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CARD6_HUMAN, Q9BX69Function: May be involved in apoptosis
|
Genomic Views
for CARD6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CARD6 gene promoter:
Nkx3-1 Nkx3-1 v4 XBP-1 Nkx3-1 v1 E47 Nkx3-1 v2 HSF2 Nkx3-1 v3 ZID Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CARD6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p13.1 Ensembl cytogenetic band: 5p13.1 HGNC cytogenetic band: 5p13.1CARD6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P040877: view genomic region
(about GC identifiers)
Start:
|
40,841,286 bp from pter |
End:
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40,860,275 bp from pter |
Size:
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18,990 bases |
Orientation:
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plus strand |
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Proteins
for CARD6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CARD6_HUMAN, Q9BX69 (See
protein sequence)Recommended Name: Caspase recruitment domain-containing protein 6 Size: 1037 amino acids; 116468 Da
Secondary accessions: Q52LR2Explore the universe of human proteins at neXtProt for CARD6: NX_Q9BX69
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BX69
CARD6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115976.2
ENSEMBL proteins: ENSP00000254691 ENSP00000371093
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
CARD6 for ontologies About GeneDecksing
CARD6 Antibody Products:
Assay Products for CARD6: |
Protein
Domains /
Families
for CARD6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CARD6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BX69ProtoNet protein and cluster: Q9BX69 1 Blocks protein family: IPB001315 CARD interaction domain
UniProtKB/Swiss-Prot: CARD6_HUMAN, Q9BX69Similarity: Contains 1 CARD domain |
Function
for CARD6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CARD6_HUMAN, Q9BX69Function: May be involved in apoptosis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CARD6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD6 |
Animal Models:
Mouse knock-out Card6tm1.1Aldu for CARD6
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Card6):
CARD6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CARD6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for CARD6
1 
Kegg Pathway (Kegg details for CARD6):
CARD6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CARD6
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for CARD6 (Q9BX693 ENSP000002546914) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
IEA | -- | | GO:0042981 | regulation of apoptotic process |
IEA | -- |
CARD6 for ontologies About GeneDecksing
|
Drugs & Compounds
for CARD6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CARD6
Search CenterWatch for drugs/clinical trials and news about CARD6
|
Transcripts
for CARD6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CARD6 gene: NM_032587.3 Unigene Cluster for CARD6: Caspase recruitment domain family, member 6 Hs.200242 [show with all ESTs]Unigene Representative Sequence: AF3561932 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000254691(uc003jmg.3) ENST00000381677
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CARD6 (NM_032587) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CARD6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD6 |
Additional cDNA sequence: AB209844.1 AF356193.1 AK304349.1 BC093825.1 2 DOTS entries: DT.95075872 DT.120813827 24/26 AceView cDNA sequences (see all 26): BQ380079 BE552385 BF000142 CK430149 AY196783 CA443032 AW613437 AF356193 BX475234 BE504923 AW192194 NM_032587 BF591169 BP366769 BI771142 AA302352 BE737100 CD634164 BF749423 CD695148 BQ773339 AW196663 R84288 R87651
GeneLoc Exon Structure
|
Expression
for CARD6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CARD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTCAGCAA
About this image
See CARD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CARD6
SOURCE GeneReport for Unigene cluster: Hs.200242
SABiosciences Expression via Pathway-Focused PCR Arrays including CARD6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CARD6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD6 |
Orthologs
for CARD6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CARD6 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for CARD6 (if available)
TreeFam Gene Tree for CARD6 (if available) |
Paralogs
for CARD6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CARD6 gene
- URGCP2
1 SIMAP similar gene for CARD6 using alignment to 2 protein entries: CARD6_HUMAN (see all proteins):CINCIN1
CARD6 for paralogs About GeneDecksing
|
Genomic Variants
for CARD6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CARD6 (40841286 - 40860275 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CARD6
1 CNV: 59265 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD6 |
|
Disorders
/ Diseases
for CARD6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CARD6 for disorders About GeneDecksing
OMIM gene information: 609986
OMIM disorders: --
3  diseases for CARD6: About MalaCardscervical adenocarcinoma cervicitis adenocarcinoma
Export disorders for CARD6 gene to outside databases
|
Publications
for CARD6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CARD6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CARD6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak- mediated pathways. (PubMed id 12775719)1, 3, 9 Stehlik C.... Reed J.C. (2003)
- Expression of CARD6, an NF-kappaB activator, in gastr ic, colorectal and oesophageal cancers. (PubMed id 20025480)1, 9 Kim S.S....Lee S.H. (2010)
- Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. (PubMed id 16418290)1, 9 Dufner A....Mak T.W. (2006)
- CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. (PubMed id 16582588)1, 9 Dufner A. and Mak T.W. (2006)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for CARD6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CARD6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CARD6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CARD6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CARD6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CARD6 gene:
Search GeneIP for patents involving CARD6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CARD6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CARD6 | | OriGene shRNA RFP for CARD6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD6 | | | OriGene Protein Over-expression Lysate for CARD6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CARD6 | | OriGene 3'-UTR Clone for CARD6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CARD6 | | OriGene Custom Protein Services for CARD6 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CARD6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD6 |
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 |  |  |  | |
| | | | Search Tocris compounds for CARD6 |
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 | | | CARD6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD6 |
|  |  |  | | | | ThermoFisher Antibodies for CARD6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD6 |
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