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Aliases for CARD19 Gene

Aliases for CARD19 Gene

  • Caspase Recruitment Domain Family Member 19 2 3 5
  • Caspase Recruitment Domain Family, Member 19 2 3
  • Bcl10-Interacting Protein With CARD 2 3
  • Bcl10-Interacting CARD Protein 3 4
  • C9orf89 3 4
  • BinCARD 3 4
  • Chromosome 9 Open Reading Frame 89 2

External Ids for CARD19 Gene

Previous HGNC Symbols for CARD19 Gene

  • C9orf89

Summaries for CARD19 Gene

GeneCards Summary for CARD19 Gene

CARD19 (Caspase Recruitment Domain Family Member 19) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CARD19 Gene

  • Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD19 Gene

Genomics for CARD19 Gene

Regulatory Elements for CARD19 Gene

Enhancers for CARD19 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CARD19 on UCSC Golden Path with GeneCards custom track

Promoters for CARD19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CARD19 on UCSC Golden Path with GeneCards custom track

Genomic Location for CARD19 Gene

93,096,129 bp from pter
93,113,283 bp from pter
17,155 bases
Plus strand

Genomic View for CARD19 Gene

Genes around CARD19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD19 Gene

Proteins for CARD19 Gene

  • Protein details for CARD19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caspase recruitment domain-containing protein 19
    Protein Accession:
    Secondary Accessions:
    • Q5BJH8
    • Q9BSY2

    Protein attributes for CARD19 Gene

    228 amino acids
    Molecular mass:
    25589 Da
    Quaternary structure:
    • Associates with BCL10 by CARD-CARD interaction (PubMed:15637807).

    Three dimensional structures from OCA and Proteopedia for CARD19 Gene

    Alternative splice isoforms for CARD19 Gene


neXtProt entry for CARD19 Gene

Proteomics data for CARD19 Gene at MOPED

Post-translational modifications for CARD19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD19 Gene

No data available for DME Specific Peptides for CARD19 Gene

Domains & Families for CARD19 Gene

Gene Families for CARD19 Gene

Protein Domains for CARD19 Gene


Suggested Antigen Peptide Sequences for CARD19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CARD domain.
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with CARD19: view

Function for CARD19 Gene

Molecular function for CARD19 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

Phenotypes for CARD19 Gene

GenomeRNAi human phenotypes for CARD19:
genes like me logo Genes that share phenotypes with CARD19: view

Animal Model Products

miRNA for CARD19 Gene

miRTarBase miRNAs that target CARD19

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CARD19 Gene

Localization for CARD19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD19 Gene

Isoform 1: Nucleus. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.
Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol NAS 15637807
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CARD19: view

No data available for Subcellular locations from COMPARTMENTS for CARD19 Gene

Pathways & Interactions for CARD19 Gene

SuperPathways for CARD19 Gene

No Data Available

Interacting Proteins for CARD19 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96LW7-CAR19_HUMAN ENSP00000364613 for CARD19 Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CARD19 Gene


No data available for Pathways by source and SIGNOR curated interactions for CARD19 Gene

Drugs & Compounds for CARD19 Gene

No Compound Related Data Available

Transcripts for CARD19 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CARD19 Gene

No ASD Table

Relevant External Links for CARD19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARD19 Gene

mRNA Expression by UniProt/SwissProt for CARD19 Gene

Tissue specificity: Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CARD19 Gene

Orthologs for CARD19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD19 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C8H9orf89 35
  • 84.34 (n)
  • 87.43 (a)
C9orf89 36
  • 87 (a)
(Mus musculus)
Mammalia 1110007C09Rik 35
  • 87.43 (n)
  • 90.16 (a)
Card19 16
1110007C09Rik 36
  • 90 (a)
(Pan troglodytes)
Mammalia C9H9orf89 35
  • 86.7 (n)
  • 82.51 (a)
C9orf89 36
  • 43 (a)
(Rattus norvegicus)
Mammalia RGD1306058 35
  • 85.82 (n)
  • 86.74 (a)
(Canis familiaris)
Mammalia C9orf89 36
  • 80 (a)
(Monodelphis domestica)
Mammalia C9orf89 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia C9orf89 36
  • 65 (a)
(Gallus gallus)
Aves C12H9ORF89 35
  • 61.42 (n)
  • 56.74 (a)
C9orf89 36
  • 55 (a)
(Anolis carolinensis)
Reptilia C9orf89 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11132 35
(Danio rerio)
Actinopterygii LOC557314 35
  • 52.79 (n)
  • 38.73 (a)
C11H9orf89 36
  • 37 (a)
Species with no ortholog for CARD19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD19 Gene

Gene Tree for CARD19 (if available)
Gene Tree for CARD19 (if available)

Paralogs for CARD19 Gene

No data available for Paralogs for CARD19 Gene

Variants for CARD19 Gene

Sequence variations from dbSNP and Humsavar for CARD19 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7857595 -- 93,102,341(+) aagtt(A/C/T)tttgc intron-variant
rs113024586 -- 93,105,179(+) GTGTG(C/G)ACGCG intron-variant
rs113110031 -- 93,099,860(+) GCCAG(A/G)TGATG intron-variant
rs113222796 -- 93,098,366(+) GGCCC(A/G)GTGAG intron-variant
rs113310348 -- 93,100,733(+) TCTGC(C/G)CACAC intron-variant

Variation tolerance for CARD19 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CARD19 Gene

Disorders for CARD19 Gene

Relevant External Links for CARD19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CARD19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD19 Gene

Publications for CARD19 Gene

  1. Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. (PMID: 15637807) Woo H.-N. … Jung Y.-K. (FEBS Lett. 2004) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. (PMID: 23633586) Chen K.E. … Martin J. (Acta Crystallogr. D 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for CARD19 Gene

Sources for CARD19 Gene