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Aliases for CARD19 Gene

Aliases for CARD19 Gene

  • Caspase Recruitment Domain Family Member 19 2 3 5
  • Bcl10-Interacting Protein With CARD 2 3
  • Bcl10-Interacting CARD Protein 3 4
  • C9orf89 3 4
  • BinCARD 3 4
  • Caspase Recruitment Domain-Containing Protein 19 3
  • Caspase Recruitment Domain Family, Member 19 2
  • Chromosome 9 Open Reading Frame 89 2

External Ids for CARD19 Gene

Previous HGNC Symbols for CARD19 Gene

  • C9orf89

Summaries for CARD19 Gene

GeneCards Summary for CARD19 Gene

CARD19 (Caspase Recruitment Domain Family Member 19) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CARD19 Gene

  • Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD19 Gene

Genomics for CARD19 Gene

Regulatory Elements for CARD19 Gene

Enhancers for CARD19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CARD19 on UCSC Golden Path with GeneCards custom track

Promoters for CARD19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CARD19 on UCSC Golden Path with GeneCards custom track

Genomic Location for CARD19 Gene

Chromosome:
9
Start:
93,096,129 bp from pter
End:
93,113,283 bp from pter
Size:
17,155 bases
Orientation:
Plus strand

Genomic View for CARD19 Gene

Genes around CARD19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD19 Gene

Proteins for CARD19 Gene

  • Protein details for CARD19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LW7-CAR19_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 19
    Protein Accession:
    Q96LW7
    Secondary Accessions:
    • Q5BJH8
    • Q9BSY2

    Protein attributes for CARD19 Gene

    Size:
    228 amino acids
    Molecular mass:
    25589 Da
    Quaternary structure:
    • Associates with BCL10 by CARD-CARD interaction (PubMed:15637807).

    Three dimensional structures from OCA and Proteopedia for CARD19 Gene

    Alternative splice isoforms for CARD19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARD19 Gene

Post-translational modifications for CARD19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD19 Gene

No data available for DME Specific Peptides for CARD19 Gene

Domains & Families for CARD19 Gene

Gene Families for CARD19 Gene

Protein Domains for CARD19 Gene

Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CARD19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LW7

UniProtKB/Swiss-Prot:

CAR19_HUMAN :
  • Contains 1 CARD domain.
Domain:
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with CARD19: view

Function for CARD19 Gene

Molecular function for CARD19 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

Gene Ontology (GO) - Molecular Function for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050700 CARD domain binding NAS 15637807
genes like me logo Genes that share ontologies with CARD19: view

Phenotypes for CARD19 Gene

genes like me logo Genes that share phenotypes with CARD19: view

Animal Model Products

miRNA for CARD19 Gene

miRTarBase miRNAs that target CARD19

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CARD19 Gene

Localization for CARD19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD19 Gene

Isoform 1: Nucleus. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.
Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 15637807
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol NAS 15637807
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with CARD19: view

No data available for Subcellular locations from COMPARTMENTS for CARD19 Gene

Pathways & Interactions for CARD19 Gene

SuperPathways for CARD19 Gene

No Data Available

Interacting Proteins for CARD19 Gene

Gene Ontology (GO) - Biological Process for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling NAS 15637807
genes like me logo Genes that share ontologies with CARD19: view

No data available for Pathways by source and SIGNOR curated interactions for CARD19 Gene

Drugs & Compounds for CARD19 Gene

No Compound Related Data Available

Transcripts for CARD19 Gene

Unigene Clusters for CARD19 Gene

Chromosome 9 open reading frame 89:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD19 Gene

No ASD Table

Relevant External Links for CARD19 Gene

GeneLoc Exon Structure for
CARD19
ECgene alternative splicing isoforms for
CARD19

Expression for CARD19 Gene

NURSA nuclear receptor signaling pathways regulating expression of CARD19 Gene:

CARD19

SOURCE GeneReport for Unigene cluster for CARD19 Gene:

Hs.434213

mRNA Expression by UniProt/SwissProt for CARD19 Gene:

Q96LW7-CAR19_HUMAN
Tissue specificity: Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CARD19 Gene

Orthologs for CARD19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C8H9orf89 34
  • 84.34 (n)
  • 87.43 (a)
C9orf89 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110007C09Rik 34
  • 87.43 (n)
  • 90.16 (a)
Card19 16
1110007C09Rik 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf89 34
  • 86.7 (n)
  • 82.51 (a)
C9orf89 35
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306058 34
  • 85.82 (n)
  • 86.74 (a)
dog
(Canis familiaris)
Mammalia C9orf89 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C9orf89 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf89 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C12H9ORF89 34
  • 61.42 (n)
  • 56.74 (a)
C9orf89 35
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf89 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11132 34
zebrafish
(Danio rerio)
Actinopterygii LOC557314 34
  • 52.79 (n)
  • 38.73 (a)
C11H9orf89 35
  • 37 (a)
OneToOne
Species where no ortholog for CARD19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD19 Gene

ENSEMBL:
Gene Tree for CARD19 (if available)
TreeFam:
Gene Tree for CARD19 (if available)

Paralogs for CARD19 Gene

No data available for Paralogs for CARD19 Gene

Variants for CARD19 Gene

Sequence variations from dbSNP and Humsavar for CARD19 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs15026 -- 93,113,171(-) GTCCC(A/C)TTGGC utr-variant-3-prime
rs7857595 -- 93,102,341(+) aagtt(A/C/T)tttgc intron-variant
rs7868952 -- 93,104,572(+) attaa(C/G)cagca intron-variant
rs7870963 -- 93,106,973(+) TGGTA(A/C)AATGA intron-variant
rs10117438 -- 93,108,997(+) TGCCA(C/T)GTGCA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CARD19 Gene

Variant ID Type Subtype PubMed ID
nsv1133736 CNV deletion 24896259
nsv526296 CNV loss 19592680

Variation tolerance for CARD19 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARD19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARD19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD19 Gene

Disorders for CARD19 Gene

Relevant External Links for CARD19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARD19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARD19

No disorders were found for CARD19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD19 Gene

Publications for CARD19 Gene

  1. Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. (PMID: 15637807) Woo H.-N. … Jung Y.-K. (FEBS Lett. 2004) 2 3 4 22 65
  2. The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. (PMID: 23633586) Chen K.E. … Martin J. (Acta Crystallogr. D 2013) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for CARD19 Gene

Sources for CARD19 Gene

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