CARD18 Gene
protein-coding GIFtS: 49
GCID: GC11M105008
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|
caspase recruitment domain family, member 18
| |
Aliases
for CARD18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Caspase Recruitment Domain Family, Member 181 2 | | Caspase-1 Inhibitor Iceberg2 3 | | ICEBERG1 2 3 5 | | Caspase Recruitment Domain-Containing Protein 182 | | UNQ58041 2 | | ICEBERG Caspase-1 Inhibitor2 | | Pseudo-ICE1 | | |
Export aliases for CARD18 gene to outside databasesPrevious GC identifer: GC11M104514 |
Summaries
for CARD18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CAR18_HUMAN, P57730Function: Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2.Down-regulates the release of IL1B
|
Genomic Views
for CARD18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CARD18 gene promoter:
MEF-2A aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CARD18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3CARD18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M105008: view genomic region
(about GC identifiers)
Start:
|
105,008,448 bp from pter |
End:
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105,010,461 bp from pter |
Size:
|
2,014 bases |
Orientation:
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minus strand |
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Proteins
for CARD18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAR18_HUMAN, P57730 (See
protein sequence)Recommended Name: Caspase recruitment domain-containing protein 18 Size: 90 amino acids; 10138 Da
Subunit: Interacts with pro-CASP1. Interacts with CARD8
1 PDB 3D structure from  and Proteopedia  for CARD18:1DGN (3D)
Secondary accessions: A2RRF8Explore the universe of human proteins at neXtProt for CARD18: NX_P57730
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P57730
CARD18 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_067546.1
ENSEMBL proteins: ENSP00000436691 ENSP00000437035 ENSP00000437187
Human Recombinant Protein Products for CARD18:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005622 | intracellular |
IEA | -- |
CARD18 for ontologies About GeneDecksing
CARD18 Antibody Products:
Assay Products for CARD18: |
Protein
Domains /
Families
for CARD18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CARD18 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P57730ProtoNet protein and cluster: P57730 1 Blocks protein family: IPB001315 CARD interaction domain
UniProtKB/Swiss-Prot: CAR18_HUMAN, P57730Similarity: Contains 1 CARD domain |
Function
for CARD18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CAR18_HUMAN, P57730Function: Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2.Down-regulates the release of IL1BInduction: Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004869 | cysteine-type endopeptidase inhibitor activity |
IEA | -- |
CARD18 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD18
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for CARD18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD18 |
|
Pathways & Interactions
for CARD18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for CARD18):
CARD18 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CARD18
1 Interacting protein for CARD18 (P577303) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
CARD18 for ontologies About GeneDecksing
|
Drugs & Compounds
for CARD18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CARD18
Search CenterWatch for drugs/clinical trials and news about CARD18 / CAR18
|
Transcripts
for CARD18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CARD18 gene: NM_021571.3 Unigene Cluster for CARD18: Caspase recruitment domain family, member 18 Hs.56279 [show with all ESTs]Unigene Representative Sequence: NM_0215713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000530950(uc021qpy.1) ENST00000526823 ENST00000532895
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD18
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CARD18 (NM_021571) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CARD18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD18 |
Additional cDNA sequence: AF208005.1 AY358231.1 BC131610.1 2 DOTS entries: DT.95122090 DT.410579 18 AceView cDNA sequences: AF208005 AA418021 AW295205 AI189838 AA046105 AA257158 AA257066 AI093154 W58453 NM_021571 AY358231 AI217611 AW085161 AA046000 AW665385 AA418193 BG184217 W58488
GeneLoc Exon Structure
|
Expression
for CARD18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CARD18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAAAGTGA
About this image
Genevestigator expression for CARD18
SOURCE GeneReport for Unigene cluster: Hs.56279
UniProtKB/Swiss-Prot: CAR18_HUMAN, P57730Tissue specificity: Primarily expressed in the heart and placenta
SABiosciences Expression via Pathway-Focused PCR Arrays including CARD18: | Inflammasomes in human mouse rat | | Apoptosis 384HT in human mouse rat | | Inflammatory Response & Autoimmunity 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CARD18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD18 |
Orthologs
for CARD18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for CARD18 (if available)
TreeFam Gene Tree for CARD18 (if available) |
Paralogs
for CARD18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CARD18 gene
- CARD172 CARD162
3 SIMAP similar genes for CARD18 using alignment to 2 protein entries: CAR18_HUMAN (see all proteins):CARD16 CASP1 CARD17
CARD18 for paralogs About GeneDecksing
|
Genomic Variants
for CARD18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CARD18 (105008448 - 105010461 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CARD18
1 CNV: 8695 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CARD18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CARD18 for disorders About GeneDecksing
OMIM gene information: 605354
OMIM disorders: --
3  diseases for CARD18: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia leukemia
Human Genome Epidemiology (HuGE) Navigator: CARD18 (1 document)
Export disorders for CARD18 gene to outside databases
|
Publications
for CARD18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CARD18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CARD18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ICEBERG: a novel inhibitor of interleukin-1beta generation. (PubMed id 11051551)1, 2, 3 Humke E.W....Dixit V.M. (2000)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PubMed id 11821383)1, 2 Razmara M.... Alnemri E.S. (2002)
- Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
- INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. (PubMed id 15383541)1 Lamkanfi M.... Vandenabeele P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. (PubMed id 11536016)9 Druilhe A....Alnemri E.S. (2001)
- Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. (PubMed id 11432859)9 Lee S.H.... Reed J.C. (2001)
|
External Searches for CARD18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CARD18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CARD18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CARD18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CARD18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CARD18 gene:
Search GeneIP for patents involving CARD18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CARD18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CARD18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD18 | | | OriGene Protein Over-expression Lysate for CARD18 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CARD18 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CARD18 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CARD18 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD18 |
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| |  |  |  |  | | | | | | Recombinant Protein for CARD18 |
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| | | |  |  |  |  | | | | ThermoFisher Antibodies for CARD18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD18 |
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