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Aliases for CARD18 Gene

Aliases for CARD18 Gene

  • Caspase Recruitment Domain Family Member 18 2 3 5
  • Caspase-1 Inhibitor Iceberg 3 4
  • ICEBERG 3 4
  • Caspase Recruitment Domain-Containing Protein 18 3
  • Caspase Recruitment Domain Family, Member 18 2
  • ICEBERG Caspase-1 Inhibitor 3
  • PSEUDO-ICE 3
  • UNQ5804 3

External Ids for CARD18 Gene

Previous GeneCards Identifiers for CARD18 Gene

  • GC11M104514
  • GC11M105008

Summaries for CARD18 Gene

GeneCards Summary for CARD18 Gene

CARD18 (Caspase Recruitment Domain Family Member 18) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD16.

UniProtKB/Swiss-Prot for CARD18 Gene

  • Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD18 Gene

Genomics for CARD18 Gene

Regulatory Elements for CARD18 Gene

Enhancers for CARD18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G105180 1.1 Ensembl ENCODE 9.9 -41.9 -41868 1.6 ELF3 SOX13 FOXA2 NFIB SAP130 CEBPG ZNF644 RAD21 TEAD3 GATA4 CARD18 GC11M105194 LOC105369469
GH11G105132 0.8 ENCODE 10.3 +6.4 6435 0.9 ELF3 FOXA2 RFX5 RARA FOS THAP11 CEBPB NFIL3 ATF4 CEBPA CARD17 CARD18 CASP1P1
GH11G105099 0.7 Ensembl ENCODE 8.7 +39.2 39169 2.5 GATA2 FOS CARD17 CARD18 CASP1P3 CARD16
GH11G105145 0.6 ENCODE 0.4 -5.4 -5375 0.2 JUND JUN CEBPB FOS EP300 NFE2L2 CARD17 CARD18 LOC105369469
GH11G105130 0.6 ENCODE 0.4 +9.0 9041 1.0 CTCF IRF2 BHLHE40 TRIM22 RAD21 TARDBP EED ZNF143 IRF1 CARD17 CASP1P2 CASP1P1 CARD18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CARD18 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CARD18 gene promoter:

Genomic Location for CARD18 Gene

Chromosome:
11
Start:
105,137,721 bp from pter
End:
105,139,734 bp from pter
Size:
2,014 bases
Orientation:
Minus strand

Genomic View for CARD18 Gene

Genes around CARD18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD18 Gene

Proteins for CARD18 Gene

  • Protein details for CARD18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57730-CAR18_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 18
    Protein Accession:
    P57730
    Secondary Accessions:
    • A2RRF8

    Protein attributes for CARD18 Gene

    Size:
    90 amino acids
    Molecular mass:
    10138 Da
    Quaternary structure:
    • Interacts with pro-CASP1. Interacts with CARD8.

    Three dimensional structures from OCA and Proteopedia for CARD18 Gene

neXtProt entry for CARD18 Gene

Post-translational modifications for CARD18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CARD18 Gene

Domains & Families for CARD18 Gene

Gene Families for CARD18 Gene

Protein Domains for CARD18 Gene

Suggested Antigen Peptide Sequences for CARD18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CARD18: view

No data available for UniProtKB/Swiss-Prot for CARD18 Gene

Function for CARD18 Gene

Molecular function for CARD18 Gene

UniProtKB/Swiss-Prot Function:
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for CARD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA --
genes like me logo Genes that share ontologies with CARD18: view

Phenotypes for CARD18 Gene

genes like me logo Genes that share phenotypes with CARD18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CARD18 Gene

Localization for CARD18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD18 gene
Compartment Confidence
cytosol 1

Gene Ontology (GO) - Cellular Components for CARD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CARD18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CARD18 Gene

Pathways & Interactions for CARD18 Gene

genes like me logo Genes that share pathways with CARD18: view

Pathways by source for CARD18 Gene

1 KEGG pathway for CARD18 Gene

Gene Ontology (GO) - Biological Process for CARD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response NAS 11051551
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042981 regulation of apoptotic process IEA --
GO:0097194 execution phase of apoptosis IBA --
genes like me logo Genes that share ontologies with CARD18: view

No data available for SIGNOR curated interactions for CARD18 Gene

Drugs & Compounds for CARD18 Gene

No Compound Related Data Available

Transcripts for CARD18 Gene

mRNA/cDNA for CARD18 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARD18 Gene

Caspase recruitment domain family, member 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD18 Gene

No ASD Table

Relevant External Links for CARD18 Gene

GeneLoc Exon Structure for
CARD18
ECgene alternative splicing isoforms for
CARD18

Expression for CARD18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CARD18 Gene

mRNA differential expression in normal tissues according to GTEx for CARD18 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x29.6) and Skin - Sun Exposed (Lower leg) (x18.3).

Protein differential expression in normal tissues from HIPED for CARD18 Gene

This gene is overexpressed in Oral epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CARD18 Gene



Protein tissue co-expression partners for CARD18 Gene

NURSA nuclear receptor signaling pathways regulating expression of CARD18 Gene:

CARD18

SOURCE GeneReport for Unigene cluster for CARD18 Gene:

Hs.56279

mRNA Expression by UniProt/SwissProt for CARD18 Gene:

P57730-CAR18_HUMAN
Tissue specificity: Primarily expressed in the heart and placenta.
genes like me logo Genes that share expression patterns with CARD18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD18 Gene

Orthologs for CARD18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CARD18 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
OneToMany
Species where no ortholog for CARD18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CARD18 Gene

ENSEMBL:
Gene Tree for CARD18 (if available)
TreeFam:
Gene Tree for CARD18 (if available)

Paralogs for CARD18 Gene

Paralogs for CARD18 Gene

(3) SIMAP similar genes for CARD18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CARD18: view

Variants for CARD18 Gene

Sequence variations from dbSNP and Humsavar for CARD18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000874513 -- 105,140,865(+) TCTTA(C/T)CTTCC upstream-variant-2KB
rs1001531130 -- 105,137,565(+) TTTTT(A/G)TGGAA downstream-variant-500B
rs1001930927 -- 105,141,415(+) CACAT(A/T)TACTC upstream-variant-2KB
rs1002171367 -- 105,137,876(+) TCATG(A/G)CCTTC utr-variant-3-prime
rs1002380808 -- 105,140,457(+) TTCAT(A/G)TTGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CARD18 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV gain 17911159
nsv1038877 CNV gain 25217958
nsv1052674 CNV loss 25217958
nsv468862 CNV gain 19166990
nsv556218 CNV gain 21841781

Variation tolerance for CARD18 Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARD18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARD18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD18 Gene

Disorders for CARD18 Gene

Relevant External Links for CARD18

Human Genome Epidemiology (HuGE) Navigator
CARD18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARD18

No disorders were found for CARD18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD18 Gene

Publications for CARD18 Gene

  1. ICEBERG: a novel inhibitor of interleukin-1beta generation. (PMID: 11051551) Humke E.W. … Dixit V.M. (Cell 2000) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PMID: 11821383) Razmara M. … Alnemri E.S. (J. Biol. Chem. 2002) 3 4 64
  4. [The expression of CARD18 in apoptin-transfected gastric cancer cells and gastric adenocarcinoma tissues]. (PMID: 23948415) Tan C. … Xiang Z. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2013) 3 64
  5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3 64

Products for CARD18 Gene

Sources for CARD18 Gene

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