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Aliases for CARD18 Gene

Aliases for CARD18 Gene

  • Caspase Recruitment Domain Family, Member 18 2 3
  • ICEBERG 3 4 6
  • Caspase-1 Inhibitor Iceberg 3 4
  • Caspase Recruitment Domain-Containing Protein 18 3
  • ICEBERG Caspase-1 Inhibitor 3
  • UNQ5804 3

External Ids for CARD18 Gene

Summaries for CARD18 Gene

GeneCards Summary for CARD18 Gene

CARD18 (Caspase Recruitment Domain Family, Member 18) is a Protein Coding gene. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD16.

UniProtKB/Swiss-Prot for CARD18 Gene

  • Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD18 Gene

Genomics for CARD18 Gene

Genomic Location for CARD18 Gene

105,137,721 bp from pter
105,139,734 bp from pter
2,014 bases
Minus strand

Genomic View for CARD18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARD18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD18 Gene

Regulatory Elements for CARD18 Gene

Transcription factor binding sites by QIAGEN in the CARD18 gene promoter:

Proteins for CARD18 Gene

  • Protein details for CARD18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caspase recruitment domain-containing protein 18
    Protein Accession:
    Secondary Accessions:
    • A2RRF8

    Protein attributes for CARD18 Gene

    90 amino acids
    Molecular mass:
    10138 Da
    Quaternary structure:
    • Interacts with pro-CASP1. Interacts with CARD8.

    Three dimensional structures from OCA and Proteopedia for CARD18 Gene

neXtProt entry for CARD18 Gene

Proteomics data for CARD18 Gene at MOPED

Post-translational modifications for CARD18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CARD18 Gene

Domains for CARD18 Gene

Protein Domains for CARD18 Gene



  • Contains 1 CARD domain.:
    • P57730
genes like me logo Genes that share domains with CARD18: view

No data available for Gene Families for CARD18 Gene

Function for CARD18 Gene

Molecular function for CARD18 Gene

UniProtKB/Swiss-Prot Function: Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
UniProtKB/Swiss-Prot Induction: Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for CARD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CARD18: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CARD18 Gene

Localization for CARD18 Gene

Gene Ontology (GO) - Cellular Components for CARD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CARD18: view

Pathways for CARD18 Gene

genes like me logo Genes that share pathways with CARD18: view

Pathways by source for CARD18 Gene

1 KEGG pathway for CARD18 Gene

Gene Ontology (GO) - Biological Process for CARD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response NAS 11051551
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CARD18: view

Transcripts for CARD18 Gene

mRNA/cDNA for CARD18 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARD18 Gene

Caspase recruitment domain family, member 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARD18 Gene

No ASD Table

Relevant External Links for CARD18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARD18 Gene

mRNA expression in normal human tissues for CARD18 Gene

mRNA differential expression in normal tissues according to GTEx for CARD18 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (29.6) and Skin - Sun Exposed (Lower leg) (18.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CARD18 Gene

SOURCE GeneReport for Unigene cluster for CARD18 Gene Hs.56279

mRNA Expression by UniProt/SwissProt for CARD18 Gene

Tissue specificity: Primarily expressed in the heart and placenta.
genes like me logo Genes that share expressions with CARD18: view

Orthologs for CARD18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CARD18 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 37
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 36 (a)
Species with no ortholog for CARD18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CARD18 Gene

Gene Tree for CARD18 (if available)
Gene Tree for CARD18 (if available)

Paralogs for CARD18 Gene

Paralogs for CARD18 Gene

Selected SIMAP similar genes for CARD18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CARD18: view

Variants for CARD18 Gene

Sequence variations from dbSNP and Humsavar for CARD18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs986153 -- 105,137,709(-) ATAGC(A/G)TTGCT downstream-variant-500B
rs986154 -- 105,137,557(-) AAAAA(C/G)TGTTC downstream-variant-500B
rs1503388 -- 105,140,010(+) GCACA(C/T)ACAGA upstream-variant-2KB
rs2089048 -- 105,140,244(+) AACTG(C/T)AGTTG upstream-variant-2KB
rs2291269 -- 105,139,464(-) AGTTA(C/T)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARD18 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv468862 CNV Gain 19166990

Relevant External Links for CARD18 Gene

HapMap Linkage Disequilibrium report

Disorders for CARD18 Gene

Relevant External Links for CARD18

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CARD18: view

No data available for UniProtKB/Swiss-Prot for CARD18 Gene

Publications for CARD18 Gene

  1. ICEBERG: a novel inhibitor of interleukin-1beta generation. (PMID: 11051551) Humke E.W. … Dixit V.M. (Cell 2000) 2 3 4
  2. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PMID: 11821383) Razmara M. … Alnemri E.S. (J. Biol. Chem. 2002) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. (PMID: 15383541) Lamkanfi M. … Vandenabeele P. (J. Biol. Chem. 2004) 3
  5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3

Products for CARD18 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
    • Inflammasomes in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CARD18
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CARD18
    • Block miRNA regulation of CARD18 using miScript Target Protectors
    • antibodies-online proteins for CARD18
    • antibodies-online antibodies for CARD18
    • antibodies-online kits for CARD18

    Sources for CARD18 Gene

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