Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CARD18 Gene

protein-coding   GIFtS: 48
GCID: GC11M105008

Caspase Recruitment Domain Family, Member 18

  Search for CARD18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Caspase Recruitment Domain Family, Member 181 2     Caspase Recruitment Domain-Containing Protein 182
ICEBERG2 3 5     ICEBERG Caspase-1 Inhibitor2
Caspase-1 Inhibitor Iceberg2 3     pseudo-ICE2
UNQ58042     

External Ids:    HGNC: 288611   Entrez Gene: 590822   Ensembl: ENSG000002555017   OMIM: 6053545   UniProtKB: P577303   

Export aliases for CARD18 gene to outside databases

Previous GC identifer: GC11M104514


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CARD18 Gene:
CARD18 (caspase recruitment domain family, member 18) is a protein-coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD17.

UniProtKB/Swiss-Prot: CAR18_HUMAN, P57730
Function: Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2.
Down-regulates the release of IL1B




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the CARD18 gene promoter:
         MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCARD18 promoter sequence
   Search Chromatin IP Primers for CARD18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARD18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

CARD18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD18 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M105008:  view genomic region     (about GC identifiers)

Start:
105,008,448 bp from pter      End:
105,010,461 bp from pter
Size:
2,014 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CAR18_HUMAN, P57730 (See protein sequence)
Recommended Name: Caspase recruitment domain-containing protein 18  
Size: 90 amino acids; 10138 Da
Subunit: Interacts with pro-CASP1. Interacts with CARD8
1 PDB 3D structure from and Proteopedia for CARD18:
1DGN (3D)    
Secondary accessions: A2RRF8

Explore the universe of human proteins at neXtProt for CARD18: NX_P57730

Explore proteomics data for CARD18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CARD18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067546.1  
    ENSEMBL proteins: 
     ENSP00000436691   ENSP00000437035   ENSP00000437187  

    CARD18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CARD18
    OriGene Protein Over-expression Lysate for CARD18
    OriGene MassSpec for CARD18
    OriGene Custom Protein Services for CARD18
    GenScript Custom Purified and Recombinant Proteins Services for CARD18
    Novus Biologicals CARD18 Proteins
    Novus Biologicals CARD18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CARD18
    Cloud-Clone Corp. Proteins for CARD18

     
    Search eBioscience for Proteins for CARD18 

    CARD18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CARD18
    Novus Biologicals CARD18 Antibodies
    Abcam antibodies for CARD18
    Cloud-Clone Corp. Antibodies for CARD18
    ThermoFisher Antibodies for CARD18
    LSBio Antibodies in human, mouse, rat for CARD18

    CARD18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CARD18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CARD18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CARD18
    Cloud-Clone Corp. CLIAs for CARD18
    Search eBioscience for ELISAs for CARD18 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry P57730

    ProtoNet protein and cluster: P57730

    1 Blocks protein domain: IPB001315 CARD interaction domain

    UniProtKB/Swiss-Prot: CAR18_HUMAN, P57730
    Similarity: Contains 1 CARD domain


    Find genes that share domains with CARD18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAR18_HUMAN, P57730
    Function: Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2.
    Down-regulates the release of IL1B
    Induction: Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CARD18           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CARD18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CARD18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CARD18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARD18

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CARD18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CARD18
    SwitchGear 3'UTR luciferase reporter plasmidCARD18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CARD18
    Predesigned siRNA for gene silencing in human, mouse, rat CARD18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CARD18

    Clone
    Products:
         
    OriGene clones in human, mouse for CARD18 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CARD18 (NM_021571)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CARD18
    Browse ESI BIO Cell Lines and PureStem Progenitors for CARD18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular IEA--

    Find genes that share ontologies with CARD18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CARD18 About    
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37


    Find genes that share SuperPaths with CARD18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for CARD18):
        NOD-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CARD18: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CARD18

    1 Interacting protein for CARD18 (P577303) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CARD17Q5XLA63I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response NAS11051551
    GO:0042981regulation of apoptotic process IEA--

    Find genes that share ontologies with CARD18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CARD18 (CAR18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CARD18 gene: 
    NM_021571.3  

    Unigene Cluster for CARD18:

    Caspase recruitment domain family, member 18
    Hs.56279  [show with all ESTs]
    Unigene Representative Sequence: NM_021571
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530950(uc021qpy.1) ENST00000526823 ENST00000532895
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CARD18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CARD18
    SwitchGear 3'UTR luciferase reporter plasmidCARD18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CARD18
    Predesigned siRNA for gene silencing in human, mouse, rat CARD18
    Clone
    Products:
         
    OriGene clones in human, mouse for CARD18 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CARD18 (NM_021571)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD18
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CARD18
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CARD18
      QuantiTect SYBR Green Assays in human, mouse, rat CARD18
      QuantiFast Probe-based Assays in human, mouse, rat CARD18

    Additional mRNA sequence: 

    AF208005.1 AY358231.1 BC131610.1 

    2 DOTS entries:

    DT.95122090  DT.410579 

    18 AceView cDNA sequences:

    AW295205 AY358231 AA046105 AA257066 AA257158 AI093154 NM_021571 AF208005 
    W58453 AI189838 AA418021 AA418193 AW665385 AI217611 AW085161 AA046000 
    BG184217 W58488 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CARD18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAAAGTGA
    CARD18 Expression
    About this image

    CARD18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CARD18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.56279

    UniProtKB/Swiss-Prot: CAR18_HUMAN, P57730
    Tissue specificity: Primarily expressed in the heart and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CARD18: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CARD18
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CARD18
    QuantiTect SYBR Green Assays in human, mouse, rat CARD18
    QuantiFast Probe-based Assays in human, mouse, rat CARD18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of mammals.

    Orthologs for CARD18 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    Uncharacterized protein
    40(a)
    1 → many
    4(250308778-250326549)


    ENSEMBL Gene Tree for CARD18 (if available)
    TreeFam Gene Tree for CARD18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CARD18 gene
    CARD172  CARD162  
    3 SIMAP similar genes for CARD18 using alignment to 2 protein entries:     CAR18_HUMAN (see all proteins):
    CARD16    CASP1    CARD17

    Find genes that share paralogs with CARD18           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CARD18 (see all 111)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403565181,2
    --105007956(+) AAAAAA/GTTCAG 1 -- int10--------
    rs1454801441,2
    --105007968(+) AAATTA/CTTTTG 1 -- int10--------
    rs116066931,2
    C,F,H--105008028(+) TTAGAA/GATTGA 1 -- int15Minor allele frequency- G:0.00NS EA NA 422
    rs1125210091,2
    F--105008049(+) CAAATT/GAGAAG 1 -- int12Minor allele frequency- G:0.02CSA WA 120
    rs1842394361,2
    --105008091(+) ATTATG/TTAACA 1 -- int10--------
    rs1491679611,2
    --105008167(+) AAAGCA/GATGAC 1 -- int10--------
    rs1885744711,2
    --105008260(+) TTGAAA/GTGCTA 1 -- int10--------
    rs1432663411,2
    --105008271(+) TCAGTC/GCTTTT 1 -- int10--------
    rs9861541,2
    C,F,H--105008284(-) AAAAAG/CTGTTC 1 -- int115Minor allele frequency- C:0.02NS EA NA WA CSA 558
    rs1483119941,2
    --105008329(+) GCCATG/TGATTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CARD18 (105008448 - 105010461 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CARD18:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468862CNV Gain19166990
    esv2750978CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CARD18
    DNA2.0 Custom Variant and Variant Library Synthesis for CARD18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605354    OMIM disorders: --


    Find genes that share disorders with CARD18           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: CARD18 (1 document)

    Export disorders for CARD18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CARD18 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CARD18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ICEBERG: a novel inhibitor of interleukin-1beta generation. (PubMed id 11051551)1, 2, 3 Humke E.W....Dixit V.M. (Cell 2000)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PubMed id 11821383)1, 2 Razmara M.... Alnemri E.S. (J. Biol. Chem. 2002)
    4. [The expression of CARD18 in apoptin-transfected gastric cancer cells and gastric adenocarcinoma tissues]. (PubMed id 23948415)1 Tan C....Xiang Z. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2013)
    5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    6. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. (PubMed id 15383541)1 Lamkanfi M.... Vandenabeele P. (J. Biol. Chem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. (PubMed id 11536016)9 Druilhe A.... Alnemri E.S. (Cell Death Differ. 2001)
    10. Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. (PubMed id 11432859)9 Lee S.H.... Reed J.C. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 59082 HGNC: 28861 AceView: ICEBERG Ensembl:ENSG00000255501 euGenes: HUgn59082
    ECgene: CARD18 Kegg: 59082 H-InvDB: CARD18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CARD18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CARD18 gene:
    Search GeneIP for patents involving CARD18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CARD18  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CARD18  
     OriGene MassSpec something-or-other for CARD18   OriGene clones in human, mouse for CARD18  
     OriGene qSTAR qPCR primer pairs in human, mouse for CARD18   OriGene Purified Protein for CARD18  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CARD18   OriGene Custom Protein Services for CARD18  

     
     
     Block miRNA regulation of human, mouse, rat CARD18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CARD18
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARD18 Predesigned siRNA for gene silencing in human, mouse, rat CARD18
     QuantiFast Probe-based Assays in human, mouse, rat CARD18 QuantiTect SYBR Green Assays in human, mouse, rat CARD18
     PCR Arrays including human, mouse / rat CARD18 Search Chromatin IP Primers for CARD18
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CARD18  GeneGlobe Interaction Network for CARD18
     Regulatory tfbs in CARD18 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CARD18 GenScript cDNA clones with any tag delivered in your preferred vector for CARD18
     GenScript Custom Assay Services for CARD18 GenScript Custom overexpressing Cell Line Services for CARD18
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CARD18 (CAR18)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CARD18 antibodies
     CARD18 proteins
     CARD18 lysates
     Antibodies for CARD18
     See all of Abcam's Antibodies, Kits and Proteins for CARD18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CARD18
     Proteins for CARD18
     Antibodies for CARD18
     ELISAs for CARD18
     CLIAs for CARD18



     Browse ESI BIO Cell Lines and PureStem Progenitors for CARD18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD18
     SwitchGear 3'UTR luciferase reporter plasmids for CARD18
     SwitchGear Promoter luciferase reporter plasmids for CARD18
     ThermoFisher Antibodies for CARD18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD18
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CARD18
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CARD18
     LSBio Antibodies in human, mouse, rat for CARD18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CARD18
      Search eBioscience for proteins for CARD18
      Search eBioscience for elisas for CARD18
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CARD18 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4