CARD17 Gene
protein-coding GIFtS: 43
GCID: GC11M104963
|
|
caspase recruitment domain family, member 17
| |
Aliases
for CARD17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Caspase Recruitment Domain Family, Member 171 2 | | Caspase Recruitment Domain-Containing Protein 172 | | INCA1 2 3 5 | | Inhibitory CARD2 | | Caspase-1 Inhibitor INCA2 3 | | Inhibitory Caspase Recruitment Domain (CARD) Protein2 | | Inhibitory Caspase Recruitment Domain Protein2 3 | | |
Export aliases for CARD17 gene to outside databasesPrevious GC identifers: GC11M104468 GC11M104896 |
Summaries
for CARD17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CAR17_HUMAN, Q5XLA6Function: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation ofpro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes.However, unlike CASP1, do not induce NF-kappa-B activation
|
Genomic Views
for CARD17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CARD17 gene promoter:
AML1a IRF-1 CUTL1 Evi-1 GATA-1 C/EBPalpha CHOP-10 IRF-2 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for CARD17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3CARD17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M104963: view genomic region
(about GC identifiers)
Start:
|
104,963,196 bp from pter |
End:
|
104,972,158 bp from pter |
Size:
|
8,963 bases |
Orientation:
|
minus strand |
|
Proteins
for CARD17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAR17_HUMAN, Q5XLA6 (See
protein sequence)Recommended Name: Caspase recruitment domain-containing protein 17 Size: 110 amino acids; 11868 Da
Subunit: Interacts with pro-CASP1
Subcellular location: Cytoplasm (By similarity)Explore the universe of human proteins at neXtProt for CARD17: NX_Q5XLA6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5XLA6
CARD17 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001007233.1
ENSEMBL proteins: ENSP00000364859
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
CARD17 for ontologies About GeneDecksing
CARD17 Antibody Products:
Assay Products for CARD17: |
Protein
Domains /
Families
for CARD17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CARD17 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5XLA6ProtoNet protein and cluster: Q5XLA6 1 Blocks protein family: IPB001315 CARD interaction domain
UniProtKB/Swiss-Prot: CAR17_HUMAN, Q5XLA6Similarity: Contains 1 CARD domain |
Function
for CARD17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CAR17_HUMAN, Q5XLA6Function: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation ofpro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes.However, unlike CASP1, do not induce NF-kappa-B activationInduction: By IFNG/IFN-gamma in monocytic cell lines
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD17
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CARD17 (NM_001007232) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CARD17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD17 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004197 | cysteine-type endopeptidase activity |
IEA | -- | | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
IEA | -- |
CARD17 for ontologies About GeneDecksing
|
Pathways & Interactions
for CARD17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CARD17
3 Interacting proteins for CARD17 (Q5XLA63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0042981 | regulation of apoptotic process |
IEA | -- |
CARD17 for ontologies About GeneDecksing
|
Drugs & Compounds
for CARD17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CARD17
Search CenterWatch for drugs/clinical trials and news about CARD17 / CAR17
|
Transcripts
for CARD17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CARD17 gene: NM_001007232.1 Unigene Cluster for CARD17: Caspase recruitment domain family, member 17 Hs.732627 [show with all ESTs]Unigene Representative Sequence: AK1281991 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000375707(uc001pir.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD17
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CARD17 (NM_001007232) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CARD17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD17 |
Additional cDNA sequence: AK128199.1 AY761064.1 3 DOTS entries: DT.101975026 DT.91700134 DT.99987671 22 AceView cDNA sequences: AI220630 BG197691 AK128199 BU753497 BX107910 BX112394 AI189378 BG210916 BG184388 BG207514 AA621311 BG203011 N29857 BG213311 N57279 BG217577 BG434571 H02187 BG181238 BG194293 AW592912 BG200939
GeneLoc Exon Structure
|
Expression
for CARD17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CARD17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.732627
UniProtKB/Swiss-Prot: CAR17_HUMAN, Q5XLA6Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including CARD17: | Apoptosis 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CARD17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD17 |
Orthologs
for CARD17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for CARD17 (if available)
TreeFam Gene Tree for CARD17 (if available) |
Paralogs
for CARD17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CARD17 gene
- CARD182 CARD162
3 SIMAP similar genes for CARD17 using alignment to 1 protein entry: CAR17_HUMAN:CARD16 CASP1 CARD18
CARD17 for paralogs About GeneDecksing
|
Genomic Variants
for CARD17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CARD17 (104963196 - 104972158 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CARD17
7 CNVs: 37661 86008 75802 8695 6899 2956 30566 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CARD17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CARD17 for disorders About GeneDecksing
OMIM gene information: 609490
OMIM disorders: --
9  diseases for CARD17: About MalaCardsmevalonic aciduria familial mediterranean fever tularemia legionnaires' disease
cowpox shigellosis neurodegenerative disease dermatitis
arthritis
7 diseases from the University of Copenhagen DISEASES database for CARD17:Cancer Familial Mediterranean fever Shigellosis Cowpox
Neurodegenerative disease Vascular disease Mevalonic aciduria Export disorders for CARD17 gene to outside databases
|
Publications
for CARD17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CARD17 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CARD17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. (PubMed id 15383541)1, 2, 3, 9 Lamkanfi M.... Vandenabeele P. (2004)
- SNARE protein mimicry by an intracellular bacterium. (PubMed id 18369472)9 Delevoye C....Subtil A. (2008)
- Identification and characterisation of coding tandem repeat variants in incA gene of Chlamydophila pecorum. (PubMed id 18651990)9 Yousef Mohamad K....Rodolakis A. (2008)
- A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins. (PubMed id 18031255)9 Kersse K....Vandenabeele P. (2007)
|
External Searches for CARD17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CARD17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CARD17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CARD17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CARD17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CARD17 gene:
Search GeneIP for patents involving CARD17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CARD17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CARD17 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD17 | | | OriGene Protein Over-expression Lysate for CARD17 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CARD17 | | OriGene 3'-UTR Clone for CARD17 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD17 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CARD17 | | OriGene Custom Protein Services for CARD17 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CARD17 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD17 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD17 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD17 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CARD17 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CARD17 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for CARD17 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD17 |
|
|
|
|
