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Aliases for CARD17 Gene

Aliases for CARD17 Gene

  • Caspase Recruitment Domain Family Member 17 2 3 5
  • Inhibitory Caspase Recruitment Domain Protein 3 4
  • Caspase-1 Inhibitor INCA 3 4
  • Inhibitory CARD 2 3
  • INCA 3 4
  • Inhibitory Caspase Recruitment Domain (CARD) Protein 3
  • Caspase Recruitment Domain-Containing Protein 17 3
  • Caspase Recruitment Domain Family, Member 17 2

External Ids for CARD17 Gene

Previous GeneCards Identifiers for CARD17 Gene

  • GC11M104468
  • GC11M104896
  • GC11M104963

Summaries for CARD17 Gene

GeneCards Summary for CARD17 Gene

CARD17 (Caspase Recruitment Domain Family Member 17) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD16.

UniProtKB/Swiss-Prot for CARD17 Gene

  • Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD17 Gene

Genomics for CARD17 Gene

Regulatory Elements for CARD17 Gene

Enhancers for CARD17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F105032 1.1 FANTOM5 ENCODE 35.4 +67.1 67143 3.7 CTCF TBP CEBPB JUNB RAD21 YY1 POLR2A CEBPA IKZF1 BCL6 CARD17 CASP4 CASP5 CARD16 CASP1P2 CASP1
GH11F105189 0.7 FANTOM5 Ensembl 32.6 -88.2 -88246 0.7 CEBPB CARD17 CASP5 CARD18 CASP4 CARD16 GC11M105194 LOC105369469
GH11F104694 1.2 FANTOM5 Ensembl ENCODE 16.3 +406.7 406704 1.3 JUND JUN CEBPB EP300 TRIM28 TCF7L2 CARD17 CASP12 LOC643733 CASP4 CARD16 CASP5 ENSG00000270449 PIR54951
GH11F105219 0.9 FANTOM5 Ensembl ENCODE 15 -118.9 -118899 0.9 CARD17 CARD16 CASP4 CASP5 GC11P105198 ENSG00000255336
GH11F105177 0.7 FANTOM5 ENCODE 17.8 -76.4 -76446 1.1 JUND FOS CARD17 CASP5 CARD16 CASP4 GC11M105194 LOC105369469
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CARD17 on UCSC Golden Path with GeneCards custom track

Promoters for CARD17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001771753 465 401

Genomic Location for CARD17 Gene

Chromosome:
11
Start:
105,092,469 bp from pter
End:
105,101,465 bp from pter
Size:
8,997 bases
Orientation:
Minus strand

Genomic View for CARD17 Gene

Genes around CARD17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD17 Gene

Proteins for CARD17 Gene

  • Protein details for CARD17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XLA6-CAR17_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 17
    Protein Accession:
    Q5XLA6

    Protein attributes for CARD17 Gene

    Size:
    110 amino acids
    Molecular mass:
    11868 Da
    Quaternary structure:
    • Interacts with pro-CASP1.

neXtProt entry for CARD17 Gene

Post-translational modifications for CARD17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CARD17 Gene

Domains & Families for CARD17 Gene

Gene Families for CARD17 Gene

Protein Domains for CARD17 Gene

Suggested Antigen Peptide Sequences for CARD17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XLA6

UniProtKB/Swiss-Prot:

CAR17_HUMAN :
  • Contains 1 CARD domain.
Domain:
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with CARD17: view

Function for CARD17 Gene

Molecular function for CARD17 Gene

UniProtKB/Swiss-Prot Function:
Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma in monocytic cell lines.

Gene Ontology (GO) - Molecular Function for CARD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CARD17: view
genes like me logo Genes that share phenotypes with CARD17: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CARD17 Gene

Localization for CARD17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD17 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD17 gene
Compartment Confidence
cytosol 1

Gene Ontology (GO) - Cellular Components for CARD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CARD17: view

Pathways & Interactions for CARD17 Gene

genes like me logo Genes that share pathways with CARD17: view

Pathways by source for CARD17 Gene

1 KEGG pathway for CARD17 Gene

Gene Ontology (GO) - Biological Process for CARD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CARD17: view

No data available for SIGNOR curated interactions for CARD17 Gene

Transcripts for CARD17 Gene

mRNA/cDNA for CARD17 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARD17 Gene

Caspase recruitment domain family, member 17:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD17 Gene

No ASD Table

Relevant External Links for CARD17 Gene

GeneLoc Exon Structure for
CARD17
ECgene alternative splicing isoforms for
CARD17

Expression for CARD17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CARD17 Gene

mRNA differential expression in normal tissues according to GTEx for CARD17 Gene

This gene is overexpressed in Whole Blood (x21.9), Esophagus - Mucosa (x7.3), and Skin - Not Sun Exposed (Suprapubic) (x6.3).

Protein differential expression in normal tissues from HIPED for CARD17 Gene

This gene is overexpressed in Oral epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CARD17 Gene



Protein tissue co-expression partners for CARD17 Gene

NURSA nuclear receptor signaling pathways regulating expression of CARD17 Gene:

CARD17

SOURCE GeneReport for Unigene cluster for CARD17 Gene:

Hs.732627

mRNA Expression by UniProt/SwissProt for CARD17 Gene:

Q5XLA6-CAR17_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with CARD17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CARD17 Gene

Orthologs for CARD17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CARD17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 41 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
OneToMany
Species where no ortholog for CARD17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CARD17 Gene

ENSEMBL:
Gene Tree for CARD17 (if available)
TreeFam:
Gene Tree for CARD17 (if available)

Paralogs for CARD17 Gene

Paralogs for CARD17 Gene

(3) SIMAP similar genes for CARD17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CARD17: view

Variants for CARD17 Gene

Sequence variations from dbSNP and Humsavar for CARD17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111274235 -- 105,100,780(+) CTTGT(C/G)TGTTT splice-acceptor-variant
rs111485049 -- 105,096,078(+) TTGTA(A/G)TACAT intron-variant
rs111519196 -- 105,103,247(+) CAGCA(A/T)AATCT upstream-variant-2KB
rs111577530 -- 105,099,190(+) ATAGA(G/T)AGTGA intron-variant, utr-variant-3-prime
rs111824382 -- 105,092,550(+) TCTGT(G/T)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CARD17 Gene

Variant ID Type Subtype PubMed ID
nsv975977 CNV duplication 23825009
nsv8871 CNV gain 18304495
nsv556218 CNV gain 21841781
nsv524985 CNV loss 19592680
nsv468862 CNV gain 19166990
nsv442241 CNV gain 18776908
nsv1159935 CNV duplication 26073780
nsv1054109 CNV loss 25217958
nsv1052674 CNV loss 25217958
nsv1049355 CNV gain 25217958
nsv1046098 CNV loss 25217958
nsv1038877 CNV gain 25217958
esv3627607 CNV loss 21293372
esv3627605 CNV gain 21293372
esv3627604 CNV loss 21293372
esv33277 CNV gain 17666407
esv2762941 CNV gain 21179565
esv2759863 CNV gain+loss 17122850
esv2750978 CNV gain 17911159
esv2745018 CNV deletion 23290073
dgv1271n100 CNV gain 25217958

Variation tolerance for CARD17 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARD17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARD17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD17 Gene

Disorders for CARD17 Gene

Relevant External Links for CARD17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARD17

No disorders were found for CARD17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD17 Gene

Publications for CARD17 Gene

  1. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. (PMID: 15383541) Lamkanfi M. … Vandenabeele P. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. (PMID: 27043298) Lu A. … Wu H. (Nat. Struct. Mol. Biol. 2016) 3 64
  3. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H. … O'Brodovich H.M. (Pediatrics 2013) 3 64
  4. SNARE protein mimicry by an intracellular bacterium. (PMID: 18369472) Delevoye C. … Subtil A. (PLoS Pathog. 2008) 22 64
  5. Identification and characterisation of coding tandem repeat variants in incA gene of Chlamydophila pecorum. (PMID: 18651990) Yousef Mohamad K. … Rodolakis A. (Vet. Res. 2008) 22 64

Products for CARD17 Gene

Sources for CARD17 Gene

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