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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARD17 Gene

protein-coding   GIFtS: 44
GCID: GC11M104963

Caspase Recruitment Domain Family, Member 17

Alzheimer's & Parkinson's Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Caspase Recruitment Domain Family, Member 171 2     Inhibitory Caspase Recruitment Domain Protein2 3
INCA2 3 5     Caspase Recruitment Domain-Containing Protein 172
Inhibitory CARD1 2     Inhibitory Caspase Recruitment Domain (CARD) Protein2
Caspase-1 Inhibitor INCA2 3     

External Ids:    HGNC: 338271   Entrez Gene: 4400682   Ensembl: ENSG000002552217   OMIM: 6094905   UniProtKB: Q5XLA63   

Export aliases for CARD17 gene to outside databases

Previous GC identifers: GC11M104468 GC11M104896


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CARD17 Gene: 
CARD17 (caspase recruitment domain family, member 17) is a protein-coding gene. Diseases associated with CARD17 include tularemia, and legionnaires' disease. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD18.

UniProtKB/Swiss-Prot: CAR17_HUMAN, Q5XLA6
Function: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of
pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in
monocytes. However, unlike CASP1, do not induce NF-kappa-B activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARD17 gene promoter:
         AML1a   IRF-1   CUTL1   Evi-1   GATA-1   C/EBPalpha   CHOP-10   IRF-2   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CARD17 promoter sequence
   Search SABiosciences Chromatin IP Primers for CARD17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

CARD17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD17 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M104963:  view genomic region     (about GC identifiers)

Start:
104,963,196 bp from pter      End:
104,972,158 bp from pter
Size:
8,963 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAR17_HUMAN, Q5XLA6 (See protein sequence)
Recommended Name: Caspase recruitment domain-containing protein 17  
Size: 110 amino acids; 11868 Da
Subunit: Interacts with pro-CASP1
Subcellular location: Cytoplasm (By similarity)

Explore the universe of human proteins at neXtProt for CARD17: NX_Q5XLA6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5XLA6

  • CARD17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001007233.1  
    ENSEMBL proteins: 
     ENSP00000364859  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--

    CARD17 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR002398 Pept_C14_p45
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q5XLA6

    ProtoNet protein and cluster: Q5XLA6

    1 Blocks protein domain: IPB001315 CARD interaction domain

    UniProtKB/Swiss-Prot: CAR17_HUMAN, Q5XLA6
    Similarity: Contains 1 CARD domain


    CARD17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAR17_HUMAN, Q5XLA6
    Function: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of
    pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in
    monocytes. However, unlike CASP1, do not induce NF-kappa-B activation
    Induction: By IFNG/IFN-gamma in monocytic cell lines

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IEA--
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
    GO:0005515protein binding ----
         
    CARD17 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CARD17

    3 Interacting proteins for CARD17 (Q5XLA63) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CARD16Q5EG053I2D: score=1 
    CARD18P577303I2D: score=1 
    CASP1P294663I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0042981regulation of apoptotic process IEA--

    CARD17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CARD17 (CAR17)

    Search CenterWatch for drugs/clinical trials and news about CARD17 / CAR17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CARD17 gene: 
    NM_001007232.1  

    Unigene Cluster for CARD17:

    Caspase recruitment domain family, member 17
    Hs.732627  [show with all ESTs]
    Unigene Representative Sequence: AK128199
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375707(uc001pir.1)

    miRNA
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    Additional mRNA sequence: 

    AK128199.1 AY761064.1 

    3 DOTS entries:

    DT.101975026  DT.91700134  DT.99987671 

    22 AceView cDNA sequences:

    AI220630 BX112394 AI189378 BG210916 BG197691 BX107910 AK128199 BU753497 
    N29857 AA621311 N57279 BG213311 BG203011 BG207514 BG184388 BG217577 
    BG434571 BG194293 BG181238 H02187 AW592912 BG200939 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CARD17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CARD17 Expression
    About this image


    SOURCE GeneReport for Unigene cluster: Hs.732627

    UniProtKB/Swiss-Prot: CAR17_HUMAN, Q5XLA6
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including CARD17: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for CARD17 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    39(a)
    1 → many
    4(250308778-250326549)


    ENSEMBL Gene Tree for CARD17 (if available)
    TreeFam Gene Tree for CARD17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CARD17 gene
    CARD182  CARD162  
    3 SIMAP similar genes for CARD17 using alignment to 1 protein entry:     CAR17_HUMAN:
    CARD16    CASP1    CARD18

    CARD17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/302 SNPs in CARD17 are shown (see all 302)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1477931221,2
    --104962783(+) AAAAAC/GAAAAA 1 -- ds50010--------
    rs1179305901,2
    F--104963033(+) GTGGGC/TGCTCA 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1931368721,2
    --104963095(+) TTCTCA/CATCGG 1 -- ds50010--------
    rs1411540721,2
    --104963102(+) TCGGTA/CGACTT 1 -- ds50010--------
    rs17858781,2
    C,F,A,H--104963106(+) TAGACC/TTCGAG 1 -- ds500129Minor allele frequency- T:0.47NS EA NA CSA WA 2891
    rs1856612371,2
    --104963147(+) TTACTA/CAACCT 1 -- ds50010--------
    rs1892665761,2
    --104963176(+) ACACAC/TATACC 1 -- ds50010--------
    rs1151019131,2
    C,F--104963218(+) TTAATG/ATACTG 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1130626711,2
    C,F--104963239(+) GAAACG/ATCTTG 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1118243821,2
    C,F--104963277(+) TCTGTG/TCTTTA 1 -- ut312Minor allele frequency- T:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for CARD17 (104963196 - 104972158 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CARD17:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745018CNV Deletion23290073
    nsv524985CNV Loss19592680
    nsv8871CNV Gain18304495
    nsv468862CNV Gain19166990
    esv33277CNV Gain17666407
    esv2750978CNV Gain17911159
    nsv442241CNV CNV18776908
    esv1015CNV CNV17122850
    dgv437e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609490    OMIM disorders: --

    8 diseases for CARD17:    About MalaCards
    tularemia    legionnaires' disease    mevalonic aciduria    shigellosis
    cowpox    familial mediterranean fever    vascular disease    dermatitis

    6 diseases from the University of Copenhagen DISEASES database for CARD17:
    Cancer     Familial Mediterranean fever     Shigellosis     Cowpox
    Neurodegenerative disease     Vascular disease

    CARD17 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for CARD17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CARD17 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CARD17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. (PubMed id 15383541)1, 2, 3, 9 Lamkanfi M.... Vandenabeele P. (2004)
    2. SNARE protein mimicry by an intracellular bacterium. (PubMed id 18369472)9 Delevoye C....Subtil A. (2008)
    3. Identification and characterisation of coding tandem repeat variants in incA gene of Chlamydophila pecorum. (PubMed id 18651990)9 Yousef Mohamad K....Rodolakis A. (2008)
    4. A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins. (PubMed id 18031255)9 Kersse K....Vandenabeele P. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440068 HGNC: 33827 AceView: LOC440068 Ensembl:ENSG00000255221 euGenes: HUgn440068
    ECgene: CARD17 H-InvDB: CARD17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CARD17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CARD17 gene:
    Search GeneIP for patents involving CARD17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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