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Aliases for CARD17 Gene

Aliases for CARD17 Gene

  • Caspase Recruitment Domain Family Member 17 2 3 5
  • Inhibitory Caspase Recruitment Domain Protein 3 4
  • Caspase Recruitment Domain Family, Member 17 2 3
  • Caspase-1 Inhibitor INCA 3 4
  • Inhibitory CARD 2 3
  • INCA 3 4
  • Inhibitory Caspase Recruitment Domain (CARD) Protein 3

External Ids for CARD17 Gene

Previous GeneCards Identifiers for CARD17 Gene

  • GC11M104468
  • GC11M104896
  • GC11M104963

Summaries for CARD17 Gene

GeneCards Summary for CARD17 Gene

CARD17 (Caspase Recruitment Domain Family Member 17) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD18.

UniProtKB/Swiss-Prot for CARD17 Gene

  • Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD17 Gene

Genomics for CARD17 Gene

Regulatory Elements for CARD17 Gene

Enhancers for CARD17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CARD17 on UCSC Golden Path with GeneCards custom track

Genomic Location for CARD17 Gene

Chromosome:
11
Start:
105,092,469 bp from pter
End:
105,101,465 bp from pter
Size:
8,997 bases
Orientation:
Minus strand

Genomic View for CARD17 Gene

Genes around CARD17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD17 Gene

Proteins for CARD17 Gene

  • Protein details for CARD17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XLA6-CAR17_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 17
    Protein Accession:
    Q5XLA6

    Protein attributes for CARD17 Gene

    Size:
    110 amino acids
    Molecular mass:
    11868 Da
    Quaternary structure:
    • Interacts with pro-CASP1.

neXtProt entry for CARD17 Gene

Proteomics data for CARD17 Gene at MOPED

Post-translational modifications for CARD17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CARD17 Gene

Domains & Families for CARD17 Gene

Gene Families for CARD17 Gene

Protein Domains for CARD17 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CARD17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XLA6

UniProtKB/Swiss-Prot:

CAR17_HUMAN :
  • Contains 1 CARD domain.
Domain:
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with CARD17: view

Function for CARD17 Gene

Molecular function for CARD17 Gene

UniProtKB/Swiss-Prot Function:
Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma in monocytic cell lines.
genes like me logo Genes that share phenotypes with CARD17: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CARD17 Gene

Localization for CARD17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD17 Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CARD17 Gene

Pathways & Interactions for CARD17 Gene

SuperPathways for CARD17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CARD17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CARD17 Gene

Drugs & Compounds for CARD17 Gene

No Compound Related Data Available

Transcripts for CARD17 Gene

mRNA/cDNA for CARD17 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARD17 Gene

Caspase recruitment domain family, member 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARD17 Gene

No ASD Table

Relevant External Links for CARD17 Gene

GeneLoc Exon Structure for
CARD17
ECgene alternative splicing isoforms for
CARD17

Expression for CARD17 Gene

mRNA expression in normal human tissues for CARD17 Gene

mRNA differential expression in normal tissues according to GTEx for CARD17 Gene

This gene is overexpressed in Whole Blood (x21.9), Esophagus - Mucosa (x7.3), and Skin - Not Sun Exposed (Suprapubic) (x6.3).

Protein differential expression in normal tissues from HIPED for CARD17 Gene

This gene is overexpressed in Oral epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CARD17 Gene



SOURCE GeneReport for Unigene cluster for CARD17 Gene Hs.732627

mRNA Expression by UniProt/SwissProt for CARD17 Gene

Q5XLA6-CAR17_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with CARD17: view

Protein tissue co-expression partners for CARD17 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CARD17 Gene

Orthologs for CARD17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CARD17 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
Species with no ortholog for CARD17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CARD17 Gene

ENSEMBL:
Gene Tree for CARD17 (if available)
TreeFam:
Gene Tree for CARD17 (if available)

Paralogs for CARD17 Gene

Paralogs for CARD17 Gene

(3) SIMAP similar genes for CARD17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CARD17: view

Variants for CARD17 Gene

Sequence variations from dbSNP and Humsavar for CARD17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs523726 -- 105,099,648(+) AACTT(A/C)TCCCA intron-variant
rs524565 -- 105,099,574(-) CCCCA(C/T)GACTC intron-variant
rs525363 -- 105,099,531(-) ATGTC(A/G)TTCAG intron-variant
rs535222 -- 105,103,184(+) TAACC(C/T)AAGGG upstream-variant-2KB
rs554818 -- 105,100,185(-) ATTTA(G/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARD17 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv468862 CNV Gain 19166990
esv1015 CNV CNV 17122850
esv2745018 CNV Deletion 23290073
dgv437e1 CNV Complex 17122850
nsv8871 CNV Gain 18304495
esv33277 CNV Gain 17666407
nsv442241 CNV CNV 18776908
nsv524985 CNV Loss 19592680

Variation tolerance for CARD17 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARD17 Gene

HapMap Linkage Disequilibrium report
CARD17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD17 Gene

Disorders for CARD17 Gene

Relevant External Links for CARD17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARD17

No disorders were found for CARD17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD17 Gene

Publications for CARD17 Gene

  1. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. (PMID: 15383541) Lamkanfi M. … Vandenabeele P. (J. Biol. Chem. 2004) 2 3 4 23 67
  2. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H. … O'Brodovich H.M. (Pediatrics 2013) 3
  3. SNARE protein mimicry by an intracellular bacterium. (PMID: 18369472) Delevoye C. … Subtil A. (PLoS Pathog. 2008) 23
  4. Identification and characterisation of coding tandem repeat variants in incA gene of Chlamydophila pecorum. (PMID: 18651990) Yousef Mohamad K. … Rodolakis A. (Vet. Res. 2008) 23
  5. A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins. (PMID: 18031255) Kersse K. … Vandenabeele P. (Biochem. Soc. Trans. 2007) 23

Products for CARD17 Gene

Sources for CARD17 Gene

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