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Aliases for CARD17 Gene

Aliases for CARD17 Gene

  • Caspase Recruitment Domain Family, Member 17 2 3
  • INCA 3 4 6
  • Inhibitory Caspase Recruitment Domain Protein 3 4
  • Caspase-1 Inhibitor INCA 3 4
  • Inhibitory CARD 2 3
  • Inhibitory Caspase Recruitment Domain (CARD) Protein 3
  • Caspase Recruitment Domain-Containing Protein 17 3

External Ids for CARD17 Gene

Previous GeneCards Identifiers for CARD17 Gene

  • GC11M104468
  • GC11M104896
  • GC11M104963

Summaries for CARD17 Gene

GeneCards Summary for CARD17 Gene

CARD17 (Caspase Recruitment Domain Family, Member 17) is a Protein Coding gene. Diseases associated with CARD17 include shigellosis. Among its related pathways are Interferon Signaling and Signaling by Interleukins. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD18.

UniProtKB/Swiss-Prot for CARD17 Gene

  • Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD17 Gene

Genomics for CARD17 Gene

Regulatory Elements for CARD17 Gene

Genomic Location for CARD17 Gene

Start:
105,092,469 bp from pter
End:
105,101,431 bp from pter
Size:
8,963 bases
Orientation:
Minus strand

Genomic View for CARD17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARD17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD17 Gene

Proteins for CARD17 Gene

  • Protein details for CARD17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XLA6-CAR17_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 17
    Protein Accession:
    Q5XLA6
    Secondary Accessions:

    Protein attributes for CARD17 Gene

    Size:
    110 amino acids
    Molecular mass:
    11868 Da
    Quaternary structure:
    • Interacts with pro-CASP1.

neXtProt entry for CARD17 Gene

Proteomics data for CARD17 Gene at MOPED

Post-translational modifications for CARD17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CARD17 Gene

Domains for CARD17 Gene

Protein Domains for CARD17 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CARD17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XLA6

UniProtKB/Swiss-Prot:

CAR17_HUMAN :
  • Q5XLA6
Domain:
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with CARD17: view

No data available for Gene Families for CARD17 Gene

Function for CARD17 Gene

Molecular function for CARD17 Gene

UniProtKB/Swiss-Prot Function: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma in monocytic cell lines.

Gene Ontology (GO) - Molecular Function for CARD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CARD17: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CARD17 Gene

Localization for CARD17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD17 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARD17 Gene COMPARTMENTS Subcellular localization image for CARD17 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 2
lysosome 2
mitochondrion 2
plasma membrane 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for CARD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CARD17: view

Pathways for CARD17 Gene

genes like me logo Genes that share pathways with CARD17: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for CARD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CARD17: view

Transcripts for CARD17 Gene

mRNA/cDNA for CARD17 Gene

(22) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARD17 Gene

Caspase recruitment domain family, member 17:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CARD17

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CARD17
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD17 Gene

No ASD Table

Relevant External Links for CARD17 Gene

GeneLoc Exon Structure for
CARD17
ECgene alternative splicing isoforms for
CARD17

Expression for CARD17 Gene

mRNA expression in normal human tissues for CARD17 Gene

mRNA differential expression in normal tissues according to GTEx for CARD17 Gene

This gene is overexpressed in Whole Blood (21.9), Esophagus - Mucosa (7.3), and Skin - Not Sun Exposed (Suprapubic) (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CARD17 Gene

SOURCE GeneReport for Unigene cluster for CARD17 Gene Hs.732627

mRNA Expression by UniProt/SwissProt for CARD17 Gene

Q5XLA6-CAR17_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with CARD17: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CARD17 Gene

Orthologs for CARD17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CARD17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
OneToMany
Species with no ortholog for CARD17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CARD17 Gene

ENSEMBL:
Gene Tree for CARD17 (if available)
TreeFam:
Gene Tree for CARD17 (if available)

Paralogs for CARD17 Gene

Paralogs for CARD17 Gene

Selected SIMAP similar genes for CARD17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CARD17: view

Variants for CARD17 Gene

Sequence variations from dbSNP and Humsavar for CARD17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs523726 -- 105,099,648(+) AACTT(A/C)TCCCA intron-variant
rs524565 -- 105,099,574(-) CCCCA(C/T)GACTC intron-variant
rs525363 -- 105,099,531(-) ATGTC(A/G)TTCAG intron-variant
rs535222 -- 105,103,184(+) TAACC(C/T)AAGGG upstream-variant-2KB
rs554818 -- 105,100,185(-) ATTTA(G/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARD17 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv468862 CNV Gain 19166990
esv1015 CNV CNV 17122850
esv2745018 CNV Deletion 23290073
dgv437e1 CNV Complex 17122850
nsv8871 CNV Gain 18304495
esv33277 CNV Gain 17666407
nsv442241 CNV CNV 18776908
nsv524985 CNV Loss 19592680

Relevant External Links for CARD17 Gene

HapMap Linkage Disequilibrium report
CARD17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD17 Gene

Disorders for CARD17 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CARD17 Gene including...

Search for CARD17 Gene in MalaCards »
genes like me logo Genes that share disorders with CARD17: view

No data available for UniProtKB/Swiss-Prot for CARD17 Gene

Publications for CARD17 Gene

  1. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. (PMID: 15383541) Lamkanfi M. … Vandenabeele P. (J. Biol. Chem. 2004) 2 3 4 23
  2. A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins. (PMID: 18031255) Kersse K. … Vandenabeele P. (Biochem. Soc. Trans. 2007) 23
  3. SNARE protein mimicry by an intracellular bacterium. (PMID: 18369472) Delevoye C. … Subtil A. (PLoS Pathog. 2008) 23
  4. Identification and characterisation of coding tandem repeat variants in incA gene of Chlamydophila pecorum. (PMID: 18651990) Yousef Mohamad K. … Rodolakis A. (Vet. Res. 2008) 23
  5. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H. … O'Brodovich H.M. (Pediatrics 2013) 3

Products for CARD17 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CARD17
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CARD17
  • Block miRNA regulation of CARD17 using miScript Target Protectors

Sources for CARD17 Gene

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