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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CARD16 Gene

protein-coding   GIFtS: 52
GCID: GC11M104912

Caspase Recruitment Domain Family, Member 16

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Caspase Recruitment Domain Family, Member 161 2     CARD Only Protein2
Caspase-1 Inhibitor COP2 3     Caspase Recruitment Domain-Containing Protein 162
Pseudo Interleukin-1 Beta Converting Enzyme2 3     Caspase-1 Dominant-Negative Inhibitor Pseudo-ICE2
COP2 3     Pseudo Interleukin-1beta Converting Enzyme2
COP12 3     Pseudo-ICE3
CARD Only Domain-Containing Protein 12 3     EC 3.4.22.368
PSEUDO-ICE2     

External Ids:    HGNC: 337011   Entrez Gene: 1147692   Ensembl: ENSG000002043977   UniProtKB: Q5EG053   

Export aliases for CARD16 gene to outside databases

Previous GC identifers: GC11M104420 GC11M100843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CARD16 Gene: 
CARD16 (caspase recruitment domain family, member 16) is a protein-coding gene. Diseases associated with CARD16 include nodular lymphocyte predominant hodgkin lymphoma, and pulmonary tuberculosis. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD17.

UniProtKB/Swiss-Prot: CAR16_HUMAN, Q5EG05
Function: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of
the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the
release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory
cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and
staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of
caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2

Gene Wiki entry for CARD16 (COP1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CARD16 gene promoter:
         AP-2alpha isoform 3   Lmo2   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCARD16 promoter sequence
   Search SABiosciences Chromatin IP Primers for CARD16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q23

CARD16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD16 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M104912:  view genomic region     (about GC identifiers)

Start:
104,912,053 bp from pter      End:
104,972,158 bp from pter
Size:
60,106 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAR16_HUMAN, Q5EG05 (See protein sequence)
Recommended Name: Caspase recruitment domain-containing protein 16  
Size: 197 amino acids; 22625 Da
Subunit: Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2
Secondary accessions: Q96RJ9
Alternative splicing: 2 isoforms:  Q5EG05-1   Q5EG05-2   

Explore the universe of human proteins at neXtProt for CARD16: NX_Q5EG05

Explore proteomics data for CARD16 at MOPED 

2 DME Specific Peptides for CARD16 (Q5EG05)
 NGLLDEL  ENATVMDK 

CARD16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CARD16 Protein Expression
REFSEQ proteins (2 alternative transcripts): 
NP_001017534.1  NP_443121.1  

ENSEMBL proteins: 
 ENSP00000364858   ENSP00000364856   ENSP00000433700   ENSP00000432485  

Human Recombinant Protein Products for CARD16: 
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OriGene Purified Protein for CARD16
OriGene Protein Over-expression Lysate for CARD16
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Novus Biologicals CARD16 Proteins
Novus Biologicals CARD16 Lysates
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CARD16 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IEA--

CARD16 for ontologies           About GeneDecksing



CARD16 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for CARD16 

Assay Products for CARD16: 
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GenScript Custom Assay Services for CARD16
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Cloud-Clone Corp. ELISAs for CARD16 
Cloud-Clone Corp. CLIAs for CARD16


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR011029 DEATH-like_dom
 IPR001315 CARD

Graphical View of Domain Structure for InterPro Entry Q5EG05

ProtoNet protein and cluster: Q5EG05

1 Blocks protein domain: IPB001315 CARD interaction domain

UniProtKB/Swiss-Prot: CAR16_HUMAN, Q5EG05
Similarity: Contains 1 CARD domain


CARD16 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CAR16_HUMAN, Q5EG05
Function: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of
the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the
release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory
cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and
staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of
caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2
Induction: Down-regulated in patients suffering of Huntington disease

     Enzyme Number (IUBMB): EC 3.4.22.362

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004197cysteine-type endopeptidase activity IEA--
GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
GO:0005515protein binding ----
     
CARD16 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CARD16:
 Decreased viability with pacli 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CARD16 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CARD16

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CARD16 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CARD16 

miRNA
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Inhib. RNA
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of CARD16

Clone
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GenScript: all cDNA clones in your preferred vector (see all 2): CARD16 (NM_001017534)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD16
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD16
Sirion Biotech Customized lentivirus for stable overexpression of CARD16 
                     Customized lentivirus expression plasmids for stable overexpression of CARD16 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD16


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CARD16

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for CARD16 (Q5EG053 ENSP000003648584) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CARD8Q9Y2G23, ENSP000003519014I2D: score=1 STRING: ENSP00000351901
CASP1P294663, ENSP000004100764I2D: score=2 STRING: ENSP00000410076
RIPK2O433533, ENSP000002207514I2D: score=2 STRING: ENSP00000220751
CARD17Q5XLA63I2D: score=1 
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0042981regulation of apoptotic process IEA--

CARD16 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CARD16 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CARD16 (CAR16)

10/14 Novoseek inferred chemical compound relationships for CARD16 gene (see all 14)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine 66.7 26 9013854 (1), 8643593 (1), 8798402 (1), 9144536 (1) (see all 26)
geranylgeraniol 49.2 1 9175767 (1)
camptothecin 35 1 20394499 (1)
etoposide 30.7 3 14555975 (1), 9054443 (1), 10930016 (1)
dutp 29.1 1 9833815 (1)
serine 29.1 3 11272269 (1), 11856484 (1), 12593666 (1)
ceramide 17.1 1 8898109 (1)
aspartate 10.3 4 10578173 (1), 15809717 (1), 17180095 (1), 9578463 (1)
irinotecan 8.59 1 16373718 (1)
butyrate 4.39 2 12603604 (2)

Search CenterWatch for drugs/clinical trials and news about CARD16 / CAR16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CARD16 gene (2 alternative transcripts): 
NM_001017534.1  NM_052889.2  

Unigene Cluster for CARD16:

Caspase recruitment domain family, member 16
Hs.348365  [show with all ESTs]
Unigene Representative Sequence: BM920134
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000375706(uc001pio.1 uc001pip.1) ENST00000375704 ENST00000525374
ENST00000528513 ENST00000527065

miRNA
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Inhib. RNA
Products:
     
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD16
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CARD16 (NM_001017534)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD16
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD16
Sirion Biotech Customized lentivirus for stable overexpression of CARD16 
                     Customized lentivirus expression plasmids for stable overexpression of CARD16 
Primer
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OriGene qPCR primer pairs and template standards for CARD16
OriGene qSTAR qPCR primer pairs in human, mouse for CARD16
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CARD16
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD16
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD16

Additional mRNA sequence: 

AF367017.1 AK311902.1 AY885669.1 BC070196.1 BC104635.1 BC117478.1 BC117480.1 

8 DOTS entries:

DT.86821038  DT.120721403  DT.120721381  DT.101975485  DT.95309552  DT.101974184  DT.102842639  DT.97842116 

24/135 AceView cDNA sequences (see all 135):

BQ673033 BG215796 AK125640 BM552543 CR592117 AU076811 BI818813 BX505922 
BM920134 BG390044 BC062327 AI081712 AU134631 X65019 AU098419 U13697 
AI493806 BC070196 AW239393 BC041689 BI819700 NM_033292 NM_033295 BV199657 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CARD16 expression in normal human tissues (normalized intensities)      CARD16 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCAGAATAC
CARD16 Expression
About this image


CARD16 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/9 selected tissues (see all 9) fully expand
 
 Endothelium (Cardiovascular System)    fully expand to see all 4 entries
         Human umbilical vein endothelial cells (HUVEC)
         Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
         Human Bladder Microvascular Endothelial Cells (HBdMEC)   
 
 Smooth Muscle (Muscoskeletal System)
         Human Intestinal Smooth Muscle Cells (HISMC)   
 
 Lower Urinary Tract (Urinary System)
         Human Bladder Microvascular Endothelial Cells (HBdMEC)   
 
 Fibroblast (Respiratory System)
         Human Pulmonary Fibroblasts (HPF)   
 
 Lung (Respiratory System)
         Human Pulmonary Fibroblasts (HPF)   

See CARD16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CARD16

SOURCE GeneReport for Unigene cluster: Hs.348365

UniProtKB/Swiss-Prot: CAR16_HUMAN, Q5EG05
Tissue specificity: Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow.
Weakly or not expressed in thymus

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD16
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD16

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for CARD16 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
--
38(a)
1 → many
4(250308778-250326549)


ENSEMBL Gene Tree for CARD16 (if available)
TreeFam Gene Tree for CARD16 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CARD16 gene
CARD172  CARD182  
3 SIMAP similar genes for CARD16 using alignment to 2 protein entries:     CAR16_HUMAN (see all proteins):
CARD17    CASP1    CARD18

CARD16 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CARD16
PGOHUM00000250389


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/224 SNPs in CARD16 are shown (see all 224)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1840805261,2
--104911598(+) CTGCCC/GGGTTT 2 -- ds50010--------
rs79285491,2
C,F,A,H--104911697(+) TCCTCC/TGTGTT 2 -- ds500121Minor allele frequency- T:0.16NS EA NA CSA WA 1955
rs1465285221,2
--104911710(+) CATGTA/GTAGGA 2 -- ds50010--------
rs675135061,2
C,F--104911713(+) GTATAG/AGAGGG 2 -- ds50016Minor allele frequency- A:0.18NA CSA WA 246
rs174475871,2
C,F,H--104911939(+) AACTGA/GCTCCA 2 -- ds50018Minor allele frequency- G:0.02NA NS EA 678
rs759039201,2
C,F--104911956(+) GGTAAA/GCACAA 2 -- ds50011Minor allele frequency- G:0.08WA 118
rs1491069161,2
--104912005(+) ACTTGC/TTCAAT 2 -- ds50010--------
rs171035971,2
C,F,H--104912012(+) CAATGG/TGATGT 2 -- ds500122Minor allele frequency- T:0.14NA NS EA CSA WA 2118
rs1890115851,2
--104912059(+) GGTTAC/TACAAG 2 -- ut310--------
rs1929204001,2
C--104912075(+) AAAATA/GGCTTG 2 -- ut310--------

HapMap Linkage Disequilibrium report for CARD16 (104912053 - 104972158 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CARD16:    About this table     
Variant IDTypeSubtypePubMed ID
nsv517089CNV Loss19592680
nsv468862CNV Gain19166990
esv2750978CNV Gain17911159
esv1015CNV CNV17122850
dgv434e1CNV Complex17122850

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CARD16
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
20/33 diseases for CARD16 (see all 33):    About MalaCards
nodular lymphocyte predominant hodgkin lymphoma    pulmonary tuberculosis    brain ischemia    spinal cord injury
non-small cell lung carcinoma    retinoblastoma    acute pancreatitis    monocytic leukemia
ischemia    colon cancer    hodgkin's lymphoma    acute myocardial infarction
huntington's disease    prader-willi syndrome    non-hodgkin lymphoma    myocardial infarction
alzheimer's disease    lateral sclerosis    amyotrophic lateral sclerosis    hypoxia


CARD16 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/14 Novoseek inferred disease relationships for CARD16 gene (see all 14)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic carcinoma 37 1 9590133 (1)
necrosis 31.9 6 15858021 (2), 11272269 (1), 14729783 (1), 16378499 (1) (see all 5)
tumors 16.3 5 15858021 (2), 11272269 (1), 9144192 (1), 9661894 (1)
retinoblastoma 9.03 2 9856788 (2)
inflammation 8.8 2 10790428 (1), 16354923 (1)
leukemia 0 1 8912861 (1)
ischemia 0 1 9861045 (1)
colon cancer 0 1 16373718 (1)
glioma 0 2 10930016 (1)
adenocarcinoma 0 2 9661876 (2)

Genetic Association Database (GAD): CARD16
Human Genome Epidemiology (HuGE) Navigator: CARD16 (4 documents)

Export disorders for CARD16 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CARD16 gene, integrated from 9 sources (see all 196):
(articles sorted by number of sources associating them with CARD16)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. (PubMed id 11432859)1, 2, 3, 9 Lee S.H.... Reed J.C. (2001)
  2. Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. (PubMed id 11536016)1, 2, 3 Druilhe A....Alnemri E.S. (2001)
  3. Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. (PubMed id 16920334)1, 2, 9 Wang X.... Friedlander R.M. (2006)
  4. Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease. (PubMed id 16354923)1, 2, 9 Wang X.... Friedlander R.M. (2005)
  5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  7. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PubMed id 11821383)1, 2 Razmara M.... Alnemri E.S. (2002)
  8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
  9. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. (PubMed id 20479761)1 Shelton R.C....Mirnics K. (2011)
  10. Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 114769 HGNC: 33701 AceView: CASP1andCOP Ensembl:ENSG00000204397 euGenes: HUgn114769
ECgene: CARD16 H-InvDB: CARD16

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CARD16 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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IP news from LifeMap Sciences, Inc.)
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Patent Information for CARD16 gene:
Search GeneIP for patents involving CARD16

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