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Aliases for CARD16 Gene

Aliases for CARD16 Gene

  • Caspase Recruitment Domain Family, Member 16 2 3
  • COP1 3 4 6
  • Pseudo Interleukin-1 Beta Converting Enzyme 3 4
  • Caspase Recruitment Domain-Only Protein 1 3 4
  • Pseudo-IL1B-Converting Enzyme 3 4
  • Caspase-1 Inhibitor COP 3 4
  • CARD-Only Protein 1 3 4
  • PSEUDO-ICE 3 4
  • COP 3 4
  • Caspase Recruitment Domain-Containing Protein 16 3
  • Caspase-1 Dominant-Negative Inhibitor Pseudo-ICE 3
  • Pseudo Interleukin-1beta Converting Enzyme 3
  • CARD Only Domain-Containing Protein 1 3
  • CARD Only Protein 3
  • EC 3.4.22.36 64

External Ids for CARD16 Gene

Summaries for CARD16 Gene

GeneCards Summary for CARD16 Gene

CARD16 (Caspase Recruitment Domain Family, Member 16) is a Protein Coding gene. Diseases associated with CARD16 include hodgkin lymphoma. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD18.

UniProtKB/Swiss-Prot for CARD16 Gene

  • Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Gene Wiki entry for CARD16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD16 Gene

Genomics for CARD16 Gene

Genomic Location for CARD16 Gene

Start:
105,041,326 bp from pter
End:
105,101,431 bp from pter
Size:
60,106 bases
Orientation:
Minus strand

Genomic View for CARD16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARD16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD16 Gene

Regulatory Elements for CARD16 Gene

Proteins for CARD16 Gene

  • Protein details for CARD16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EG05-CAR16_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 16
    Protein Accession:
    Q5EG05
    Secondary Accessions:
    • Q96RJ9

    Protein attributes for CARD16 Gene

    Size:
    197 amino acids
    Molecular mass:
    22625 Da
    Quaternary structure:
    • Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2.

    Alternative splice isoforms for CARD16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARD16 Gene

Proteomics data for CARD16 Gene at MOPED

Selected DME Specific Peptides for CARD16 Gene

Post-translational modifications for CARD16 Gene

No Post-translational modifications

Other Protein References for CARD16 Gene

Domains for CARD16 Gene

Protein Domains for CARD16 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CAR16_HUMAN
Domain:
  • Contains 1 CARD domain.:
    • Q5EG05
genes like me logo Genes that share domains with CARD16: view

No data available for Gene Families for CARD16 Gene

Function for CARD16 Gene

Molecular function for CARD16 Gene

UniProtKB/Swiss-Prot Function: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
UniProtKB/Swiss-Prot Induction: Down-regulated in patients suffering of Huntington disease.

Enzyme Numbers (IUBMB) for CARD16 Gene

Gene Ontology (GO) - Molecular Function for CARD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CARD16: view

Phenotypes for CARD16 Gene

GenomeRNAi human phenotypes for CARD16:
genes like me logo Genes that share phenotypes with CARD16: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CARD16 Gene

Localization for CARD16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CARD16 Gene COMPARTMENTS Subcellular localization image for CARD16 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CARD16 Gene

Pathways for CARD16 Gene

SuperPathways for CARD16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CARD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CARD16: view

No data available for Pathways by source for CARD16 Gene

Compounds for CARD16 Gene

(14) Novoseek inferred chemical compound relationships for CARD16 Gene

Compound -log(P) Hits PubMed IDs
cysteine 66.7 26
geranylgeraniol 49.2 1
camptothecin 35 1
etoposide 30.7 3
dutp 29.1 1
genes like me logo Genes that share compounds with CARD16: view

Transcripts for CARD16 Gene

Unigene Clusters for CARD16 Gene

Caspase recruitment domain family, member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARD16 Gene

No ASD Table

Relevant External Links for CARD16 Gene

GeneLoc Exon Structure for
CARD16
ECgene alternative splicing isoforms for
CARD16

Expression for CARD16 Gene

mRNA expression in normal human tissues for CARD16 Gene

mRNA differential expression in normal tissues according to GTEx for CARD16 Gene

This gene is overexpressed in Whole Blood (11.8) and Spleen (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARD16 Gene

SOURCE GeneReport for Unigene cluster for CARD16 Gene Hs.348365

mRNA Expression by UniProt/SwissProt for CARD16 Gene

Q5EG05-CAR16_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
genes like me logo Genes that share expressions with CARD16: view

Orthologs for CARD16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CARD16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CARD16 37
  • 98 (a)
OneToOne
CASP1 36
  • 98.48 (n)
  • 96.95 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 38 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 45 (a)
OneToMany
Species with no ortholog for CARD16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CARD16 Gene

ENSEMBL:
Gene Tree for CARD16 (if available)
TreeFam:
Gene Tree for CARD16 (if available)

Paralogs for CARD16 Gene

Paralogs for CARD16 Gene

Selected SIMAP similar genes for CARD16 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CARD16 Gene

genes like me logo Genes that share paralogs with CARD16: view

Variants for CARD16 Gene

Sequence variations from dbSNP and Humsavar for CARD16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs473394 -- 105,044,717(+) CACGT(A/C)ATCAA intron-variant
rs489715 -- 105,042,726(+) ATAGA(A/G)AAAAA intron-variant
rs490565 -- 105,042,787(+) AGTGA(A/G)TATCC intron-variant
rs493426 -- 105,043,138(+) AACTG(G/T)AAGAG intron-variant
rs542571 - 105,041,494(+) GTATG(A/T)TCCTC reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CARD16 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv468862 CNV Gain 19166990
dgv434e1 CNV Complex 17122850
esv1015 CNV CNV 17122850
nsv517089 CNV Loss 19592680

Relevant External Links for CARD16 Gene

HapMap Linkage Disequilibrium report
CARD16

Disorders for CARD16 Gene

(1) MalaCards Diseases for CARD16 Gene

Search for CARD16 Gene in MalaCards »

(14) Novoseek inferred disease relationships for CARD16 Gene

Disease -log(P) Hits PubMed IDs
pancreatic carcinoma 37 1
necrosis 31.9 6
tumors 16.3 5
retinoblastoma 9.03 2
inflammation 8.8 2

Relevant External Links for CARD16

Genetic Association Database (GAD)
CARD16
Human Genome Epidemiology (HuGE) Navigator
CARD16
genes like me logo Genes that share disorders with CARD16: view

No data available for UniProtKB/Swiss-Prot for CARD16 Gene

Publications for CARD16 Gene

  1. Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. (PMID: 11432859) Lee S.H. … Reed J.C. (J. Biol. Chem. 2001) 2 3 4 23
  2. Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. (PMID: 16920334) Wang X. … Friedlander R.M. (Biochim. Biophys. Acta 2006) 3 4 23
  3. Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease. (PMID: 16354923) Wang X. … Friedlander R.M. (J. Neurosci. 2005) 3 4 23
  4. Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. (PMID: 11536016) Druilhe A. … Alnemri E.S. (Cell Death Differ. 2001) 2 3 4
  5. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PMID: 11821383) Razmara M. … Alnemri E.S. (J. Biol. Chem. 2002) 3 4

Products for CARD16 Gene

Sources for CARD16 Gene

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