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Aliases for CARD16 Gene

Aliases for CARD16 Gene

  • Caspase Recruitment Domain Family Member 16 2 3 5
  • Pseudo Interleukin-1 Beta Converting Enzyme 3 4
  • Caspase Recruitment Domain-Only Protein 1 3 4
  • Pseudo-IL1B-Converting Enzyme 3 4
  • Caspase-1 Inhibitor COP 3 4
  • CARD-Only Protein 1 3 4
  • PSEUDO-ICE 3 4
  • COP1 3 4
  • COP 3 4
  • Caspase Recruitment Domain-Containing Protein 16 3
  • Caspase-1 Dominant-Negative Inhibitor Pseudo-ICE 3
  • Caspase Recruitment Domain Family, Member 16 2
  • Pseudo Interleukin-1beta Converting Enzyme 3
  • CARD Only Domain-Containing Protein 1 3
  • CARD Only Protein 3
  • EC 3.4.22.36 61

External Ids for CARD16 Gene

Previous GeneCards Identifiers for CARD16 Gene

  • GC11M104420
  • GC11M104912
  • GC11M100843

Summaries for CARD16 Gene

GeneCards Summary for CARD16 Gene

CARD16 (Caspase Recruitment Domain Family Member 16) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD17.

UniProtKB/Swiss-Prot for CARD16 Gene

  • Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Gene Wiki entry for CARD16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD16 Gene

Genomics for CARD16 Gene

Regulatory Elements for CARD16 Gene

Enhancers for CARD16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G105032 1.4 FANTOM5 ENCODE dbSUPER 12.4 +67.1 67109 3.7 CTCF TBP TAF1 CEBPB JUNB MAX CEBPG RAD21 YY1 JUND CARD17 CASP4 CASP5 CARD16 CASP1P2 CASP1
GH11G104965 1.2 FANTOM5 ENCODE 7.3 +133.7 133694 4.9 ELF3 TBP ARID4B BRCA1 ZNF48 RAD21 YY1 GATA2 FOS ETV6 CASP4 LOC643733 CASP5 CASP12 CARD17 CARD16
GH11G104704 1.3 FANTOM5 Ensembl ENCODE 6.1 +395.4 395351 3.6 PKNOX1 MTA2 JUNB YY1 ARID3A GATA2 ETV6 FOXP2 SPI1 CASP4 CARD17 LOC643733 CARD16 LOC102723895 CASP5 ENSG00000270449 PIR54951
GH11G105043 1.5 FANTOM5 ENCODE dbSUPER 4.8 +55.4 55398 4.6 FOXA2 ATF1 MLX ARID4B DMAP1 BRCA1 YY1 GATA2 FOS SP5 CASP5 CARD17 CARD16 CASP1 CASP1P2
GH11G104798 0.9 Ensembl ENCODE 6.5 +302.2 302237 1.4 PKNOX1 FOXA2 TEAD1 HMG20A TBX21 JUND GATA2 CEBPA TCF7 FOS CARD16 PIR51559 PIR54951
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CARD16 on UCSC Golden Path with GeneCards custom track

Genomic Location for CARD16 Gene

Chromosome:
11
Start:
105,040,306 bp from pter
End:
105,101,431 bp from pter
Size:
61,126 bases
Orientation:
Minus strand

Genomic View for CARD16 Gene

Genes around CARD16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD16 Gene

Proteins for CARD16 Gene

  • Protein details for CARD16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EG05-CAR16_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 16
    Protein Accession:
    Q5EG05
    Secondary Accessions:
    • Q96RJ9

    Protein attributes for CARD16 Gene

    Size:
    197 amino acids
    Molecular mass:
    22625 Da
    Quaternary structure:
    • Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2.

    Alternative splice isoforms for CARD16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARD16 Gene

Selected DME Specific Peptides for CARD16 Gene

Q5EG05:
  • ENATVMDK
  • NGLLDEL

Post-translational modifications for CARD16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD16 Gene

Domains & Families for CARD16 Gene

Gene Families for CARD16 Gene

Protein Domains for CARD16 Gene

Suggested Antigen Peptide Sequences for CARD16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CARD16: view

No data available for UniProtKB/Swiss-Prot for CARD16 Gene

Function for CARD16 Gene

Molecular function for CARD16 Gene

UniProtKB/Swiss-Prot Function:
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
UniProtKB/Swiss-Prot Induction:
Down-regulated in patients suffering of Huntington disease.

Enzyme Numbers (IUBMB) for CARD16 Gene

Gene Ontology (GO) - Molecular Function for CARD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CARD16: view
genes like me logo Genes that share phenotypes with CARD16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CARD16 Gene

Localization for CARD16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD16 gene
Compartment Confidence
cytosol 4
extracellular 2
nucleus 2
plasma membrane 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CARD16 Gene

Pathways & Interactions for CARD16 Gene

genes like me logo Genes that share pathways with CARD16: view

Pathways by source for CARD16 Gene

1 KEGG pathway for CARD16 Gene

Gene Ontology (GO) - Biological Process for CARD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CARD16: view

No data available for SIGNOR curated interactions for CARD16 Gene

Drugs & Compounds for CARD16 Gene

(9) Drugs for CARD16 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CARD16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CARD16: view

Transcripts for CARD16 Gene

Unigene Clusters for CARD16 Gene

Caspase recruitment domain family, member 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD16 Gene

No ASD Table

Relevant External Links for CARD16 Gene

GeneLoc Exon Structure for
CARD16
ECgene alternative splicing isoforms for
CARD16

Expression for CARD16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CARD16 Gene

mRNA differential expression in normal tissues according to GTEx for CARD16 Gene

This gene is overexpressed in Whole Blood (x11.8) and Spleen (x6.9).

Protein differential expression in normal tissues from HIPED for CARD16 Gene

This gene is overexpressed in Monocytes (19.4), Peripheral blood mononuclear cells (9.9), Cervix (9.0), Ovary (8.3), and Spleen (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CARD16 Gene



Protein tissue co-expression partners for CARD16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CARD16 Gene:

CARD16

SOURCE GeneReport for Unigene cluster for CARD16 Gene:

Hs.348365

mRNA Expression by UniProt/SwissProt for CARD16 Gene:

Q5EG05-CAR16_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.

Evidence on tissue expression from TISSUES for CARD16 Gene

  • Spleen(4.4)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with CARD16: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD16 Gene

Orthologs for CARD16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CARD16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP1 34
  • 98.48 (n)
CARD16 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 38 (a)
OneToMany
Species where no ortholog for CARD16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CARD16 Gene

ENSEMBL:
Gene Tree for CARD16 (if available)
TreeFam:
Gene Tree for CARD16 (if available)

Paralogs for CARD16 Gene

Paralogs for CARD16 Gene

(3) SIMAP similar genes for CARD16 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CARD16 Gene

genes like me logo Genes that share paralogs with CARD16: view

Variants for CARD16 Gene

Sequence variations from dbSNP and Humsavar for CARD16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000008375 -- 105,045,009(+) GCCAA(C/T)TCTGT intron-variant
rs1001091529 -- 105,047,273(+) TAAGG(G/T)TTTCA upstream-variant-2KB
rs1001791535 -- 105,040,678(+) GGCAG(A/G)CAATT utr-variant-3-prime
rs1001949638 -- 105,046,381(+) ATTAA(C/T)AGAAA upstream-variant-2KB
rs1001950365 -- 105,040,325(+) TATAT(A/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CARD16 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV gain 17911159
esv2759863 CNV gain+loss 17122850
nsv1038877 CNV gain 25217958
nsv1041081 CNV loss 25217958
nsv1046098 CNV loss 25217958
nsv1052674 CNV loss 25217958
nsv468862 CNV gain 19166990
nsv517089 CNV loss 19592680
nsv556218 CNV gain 21841781
nsv556219 CNV loss 21841781
nsv951065 CNV duplication 24416366
nsv983059 CNV duplication 23825009

Variation tolerance for CARD16 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 62.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARD16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARD16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD16 Gene

Disorders for CARD16 Gene

Relevant External Links for CARD16

Genetic Association Database (GAD)
CARD16
Human Genome Epidemiology (HuGE) Navigator
CARD16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CARD16

No disorders were found for CARD16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD16 Gene

Publications for CARD16 Gene

  1. Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. (PMID: 11432859) Lee S.H. … Reed J.C. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. (PMID: 16920334) Wang X. … Friedlander R.M. (Biochim. Biophys. Acta 2006) 3 4 22 64
  3. Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease. (PMID: 16354923) Wang X. … Friedlander R.M. (J. Neurosci. 2005) 3 4 22 64
  4. Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. (PMID: 11536016) Druilhe A. … Alnemri E.S. (Cell Death Differ. 2001) 2 3 4 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for CARD16 Gene

Sources for CARD16 Gene

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