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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CARD16 Gene

protein-coding GIFtS: 49
GCID: GC11M104912

caspase recruitment domain family, member 16

Explore 36 diseases affiliated with
CARD16 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Caspase Recruitment Domain Family, Member 16¹ ²		CARD Only Protein²
COP¹ ² ³		Caspase Recruitment Domain-Containing Protein 16²
COP1¹ ² ³		Caspase-1 Dominant-Negative Inhibitor Pseudo-ICE²
PSEUDO-ICE¹ ²		Pseudo Interleukin-1beta Converting Enzyme²
Caspase-1 Inhibitor COP² ³		Pseudo-ICE³
Pseudo Interleukin-1 Beta Converting Enzyme² ³		EC 3.4.22.36⁸
CARD Only Domain-Containing Protein 1² ³

External Ids:	HGNC: 33701¹	Entrez Gene: 114769²	Ensembl: ENSG00000204397⁷	UniProtKB: Q5EG05³

Export aliases for CARD16 gene to outside databases

Previous GC identifers: GC11M104420 GC11M100843

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CAR16_HUMAN, Q5EG05

Function: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the

proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of

IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine

response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and

staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases

CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2

Gene Wiki entry for CARD16 (COP1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CARD16 gene promoter:
AP-2alpha isoform 3 Lmo2 AP-2alpha isoform 2 AP-2alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CARD16 promoter sequence

Search SABiosciences Chromatin IP Primers for CARD16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q23

CARD16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD16 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M104912: view genomic region (about GC identifiers)

Start:	104,912,053 bp from pter	End:	104,972,158 bp from pter
Size:	60,106 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAR16_HUMAN, Q5EG05 (See protein sequence)

Recommended Name: Caspase recruitment domain-containing protein 16

Size: 197 amino acids; 22625 Da

Subunit: Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2

Secondary accessions: Q96RJ9

Alternative splicing: 2 isoforms: Q5EG05-1 Q5EG05-2

Explore the universe of human proteins at neXtProt for CARD16: NX_Q5EG05

2 DME Specific Peptides for CARD16 (Q5EG05)

NGLLDEL

ENATVMDK

CARD16 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001017534.1 NP_443121.1

ENSEMBL proteins:

ENSP00000364858 ENSP00000364856 ENSP00000433700 ENSP00000432485

Human Recombinant Protein Products:

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	OriGene Purified Protein: CARD16 OriGene Protein Over-expression Lysate (see all 2): CARD16 OriGene Custom Protein Services for CARD16
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	Novus Biologicals CARD16 Proteins Novus Biologicals CARD16 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CARD16

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

CARD16 for ontologies About GeneDecksing

CARD16 Antibody Products:

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	Novus Biologicals CARD16 Antibodies
	Search for Antibodies for CARD16 at Abcam
	Uscn Antibodies for CARD16
	Search ThermoFisher Antibodies for CARD16

Assay Products for CARD16:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CARD16

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CARD16 for domains About GeneDecksing

2 InterPro domains/families:

IPR011029 DEATH-like_dom

IPR001315 CARD

Graphical View of Domain Structure for InterPro Entry Q5EG05

ProtoNet protein and cluster: Q5EG05

1 Blocks protein family: IPB001315 CARD interaction domain

UniProtKB/Swiss-Prot: CAR16_HUMAN, Q5EG05

Similarity: Contains 1 CARD domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CAR16_HUMAN, Q5EG05

Function: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the

proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of

IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine

response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and

staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases

CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2

Induction: Down-regulated in patients suffering of Huntington disease

Enzyme Number (IUBMB): EC 3.4.22.36²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CARD16 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARD16
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CARD16

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD16 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD16 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CARD16 (NM_001017534)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD16

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CARD16
		Search LifeMap BioReagents cell lines for CARD16

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD16

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004869	cysteine-type endopeptidase inhibitor activity	IEA	--

CARD16 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CARD16:

Decreased viability with pacli

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CARD16

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for CARD16 (Q5EG05³ ENSP00000364858⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CARD8	Q9Y2G2³, ENSP00000351901⁴	I2D: score=1 STRING: ENSP00000351901
CASP1	P29466³, ENSP00000410076⁴	I2D: score=2 STRING: ENSP00000410076
RIPK2	O43353³, ENSP00000220751⁴	I2D: score=2 STRING: ENSP00000220751
CARD17	Q5XLA6³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042981	regulation of apoptotic process	IEA	--

CARD16 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CARD16 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CARD16
10/14 Novoseek chemical compound relationships for CARD16 gene (see all 14) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine	66.7	26	9013854 (1), 8643593 (1), 8798402 (1), 9144536 (1) (see all 26)
geranylgeraniol	49.2	1	9175767 (1)
camptothecin	35	1	20394499 (1)
etoposide	30.7	3	14555975 (1), 9054443 (1), 10930016 (1)
dutp	29.1	1	9833815 (1)
serine	29.1	3	11272269 (1), 11856484 (1), 12593666 (1)
ceramide	17.1	1	8898109 (1)
aspartate	10.3	4	10578173 (1), 15809717 (1), 17180095 (1), 9578463 (1)
irinotecan	8.59	1	16373718 (1)
butyrate	4.39	2	12603604 (2)

Search CenterWatch for drugs/clinical trials and news about CARD16 / CAR16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CARD16 gene (2 alternative transcripts):

NM_001017534.1 NM_052889.2

Unigene Cluster for CARD16:

Caspase recruitment domain family, member 16

Hs.348365 [show with all ESTs]

Unigene Representative Sequence: BM920134

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375706(uc001pio.1 uc001pip.1) ENST00000375704 ENST00000525374

ENST00000528513 ENST00000527065

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CARD16 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARD16
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD16 OriGene shRNA RFP: CARD16 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD16

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD16 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD16 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD16

Additional cDNA sequence:

AF367017.1 AK311902.1 AY885669.1 BC070196.1 BC104635.1 BC117478.1 BC117480.1

8 DOTS entries:

DT.86821038 DT.120721403 DT.120721381 DT.101975485 DT.95309552 DT.101974184 DT.102842639 DT.97842116

24/135 AceView cDNA sequences (see all 135):

X65019 AU098419 BG390044 BG215796 AI081712 BQ673033 AU076811 BX505922

BM552543 BI818813 AW239393 BC041689 AK125640 BM920134 BC062327 BI819700

BC070196 AI493806 U13697 AU134631 CR592117 U13698 BV203443 BM822412

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CARD16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAGAATAC

About this image

CARD16 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Embryoid bodies (Two-step protocol fo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CARD16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CARD16

SOURCE GeneReport for Unigene cluster: Hs.348365

UniProtKB/Swiss-Prot: CAR16_HUMAN, Q5EG05

Tissue specificity: Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly

or not expressed in thymus

SABiosciences Custom PCR Arrays for CARD16

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD16

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for CARD16 (if available)
TreeFam Gene Tree for CARD16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CARD16 gene

CARD17² CARD18²

3 SIMAP similar genes for CARD16 using alignment to 2 protein entries: CAR16_HUMAN (see all proteins):

CARD17 CASP1 CARD18

CARD16 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CARD16
PGOHUM00000250389

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184080526^1,2		--	104911598(+)	`CTGCCC/GGGTTT`	2	--	ds500¹		0	--	--	--	--
rs7928549^1,2	C,F,A,H,	--	104911697(+)	`TCCTCC/TGTGTT`	2	--	ds500¹		21		NS EA NA CSA WA	1955
rs146528522^1,2		--	104911710(+)	`CATGTA/GTAGGA`	2	--	ds500¹		0	--	--	--	--
rs67513506^1,2	C,F,	--	104911713(+)	`GTATAG/AGAGGG`	2	--	ds500¹		6		NA CSA WA	246
rs17447587^1,2	C,F,H,	--	104911939(+)	`AACTGA/GCTCCA`	2	--	ds500¹		8		NA NS EA	678
rs75903920^1,2	C,F,	--	104911956(+)	`GGTAAA/GCACAA`	2	--	ds500¹		1		WA	118
rs149106916^1,2		--	104912005(+)	`ACTTGC/TTCAAT`	2	--	ds500¹		0	--	--	--	--
rs17103597^1,2	C,F,H,	--	104912012(+)	`CAATGG/TGATGT`	2	--	ds500¹		22		NA NS EA CSA WA	2118
rs189011585^1,2		--	104912059(+)	`GGTTAC/TACAAG`	2	--	ut3¹		0	--	--	--	--
rs192920400^1,2		--	104912075(+)	`AAAATA/GGCTTG`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CARD16 (104912053 - 104972158 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CARD16
2 CNVs: 8695 2956

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD16

DNA2.0 Custom Variant and Variant Library Synthesis for CARD16

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CARD16 for disorders About GeneDecksing

20/36 diseases for CARD16 (see all 36): About MalaCards

spinal cord injury prader-willi syndrome non-small cell lung carcinoma non-hodgkin lymphoma

amyotrophic lateral sclerosis myocardial infarction lateral sclerosis acute myocardial infarction

hodgkin's lymphoma monocytic leukemia brain ischemia alzheimer's disease

ischemia pulmonary tuberculosis pancreatic carcinoma colon cancer

lymphoblastic leukemia lung carcinoma huntington's disease retinoblastoma

10/14 Novoseek disease relationships for CARD16 gene (see all 14) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic carcinoma	37	1	9590133 (1)
necrosis	31.9	6	15858021 (2), 11272269 (1), 14729783 (1), 16378499 (1) (see all 5)
tumors	16.3	5	15858021 (2), 11272269 (1), 9144192 (1), 9661894 (1)
retinoblastoma	9.03	2	9856788 (2)
inflammation	8.8	2	10790428 (1), 16354923 (1)
leukemia	0	1	8912861 (1)
ischemia	0	1	9861045 (1)
colon cancer	0	1	16373718 (1)
glioma	0	2	10930016 (1)
adenocarcinoma	0	2	9661876 (2)

Human Genome Epidemiology (HuGE) Navigator: CARD16 (4 documents)

Export disorders for CARD16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CARD16 gene, integrated from 9 sources (see all 194):
(articles sorted by number of sources associating them with CARD16)

Utopia: connect your pdf to the dynamic
world of online information

Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. (PubMed id 11432859)^{1, 2, 3, 9} Lee S.H.... Reed J.C. (2001)
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. (PubMed id 11536016)^{1, 2, 3} Druilhe A....Alnemri E.S. (2001)
Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. (PubMed id 16920334)^{1, 2, 9} Wang X.... Friedlander R.M. (2006)
Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease. (PubMed id 16354923)^{1, 2, 9} Wang X.... Friedlander R.M. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PubMed id 11821383)^{1, 2} Razmara M.... Alnemri E.S. (2002)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. (PubMed id 20479761)¹ Shelton R.C....Mirnics K. (2011)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 114769	HGNC: 33701	AceView: CASP1andCOP	Ensembl:ENSG00000204397	euGenes: HUgn114769
ECgene: CARD16	H-InvDB: CARD16

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CARD16	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CARD16 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CARD16 gene:
Search GeneIP for patents involving CARD16

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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CARD16 Gene

caspase recruitment domain family, member 16

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CARD16 Gene

caspase recruitment domain family, member 16

Aliasesfor CARD16 gene

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