Aliases for CARD14 Gene
External Ids for CARD14 Gene
Previous HGNC Symbols for CARD14 Gene
Previous GeneCards Identifiers for CARD14 Gene
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
GeneCards Summary for CARD14 Gene
CARD14 (Caspase Recruitment Domain Family Member 14) is a Protein Coding gene. Diseases associated with CARD14 include pityriasis rubra pilaris and psoriasis 2. Among its related pathways are NF-KappaB Family Pathway and TCR Signaling (Qiagen). GO annotations related to this gene include CARD domain binding. An important paralog of this gene is CARD11.
UniProtKB/Swiss-Prot for CARD14 Gene
Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.