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Aliases for CARD11 Gene

Aliases for CARD11 Gene

  • Caspase Recruitment Domain Family, Member 11 2 3
  • CARMA1 3 4 6
  • Bcl10-Interacting Maguk Protein 3 2 3
  • CARD-Containing MAGUK Protein 1 3 4
  • Carma 1 3 4
  • BENTA 3 6
  • BIMP3 3 6
  • IMD11 3 6
  • PPBL 3 6
  • Caspase Recruitment Domain-Containing Protein 11 3
  • Card-Maguk Protein 1 2

External Ids for CARD11 Gene

Previous GeneCards Identifiers for CARD11 Gene

  • GC07M002590
  • GC07M002690
  • GC07M002719

Summaries for CARD11 Gene

Entrez Gene Summary for CARD11 Gene

  • The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

GeneCards Summary for CARD11 Gene

CARD11 (Caspase Recruitment Domain Family, Member 11) is a Protein Coding gene. Diseases associated with CARD11 include persistent polyclonal b-cell lymphocytosis and immunodeficiency 11. Among its related pathways are PI-3K cascade and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include guanylate kinase activity and CARD domain binding. An important paralog of this gene is CARD10.

UniProtKB/Swiss-Prot for CARD11 Gene

  • Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10

Gene Wiki entry for CARD11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD11 Gene

Genomics for CARD11 Gene

Regulatory Elements for CARD11 Gene

Genomic Location for CARD11 Gene

2,906,075 bp from pter
3,043,945 bp from pter
137,871 bases
Minus strand

Genomic View for CARD11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CARD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD11 Gene

Proteins for CARD11 Gene

  • Protein details for CARD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caspase recruitment domain-containing protein 11
    Protein Accession:
    Secondary Accessions:
    • A4D1Z7
    • Q2NKN7
    • Q548H3

    Protein attributes for CARD11 Gene

    1154 amino acids
    Molecular mass:
    133284 Da
    Quaternary structure:
    • Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail).
    • Sequence=AAG53402.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI11720.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ96893.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAL23962.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CARD11 Gene

neXtProt entry for CARD11 Gene

Proteomics data for CARD11 Gene at MOPED

Post-translational modifications for CARD11 Gene

  • Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CARD11 (CARD11/CARMA1)
  • Cell Signaling Technology (CST) Antibodies for CARD11 (CARD11)

No data available for DME Specific Peptides for CARD11 Gene

Domains for CARD11 Gene

Protein Domains for CARD11 Gene

Suggested Antigen Peptide Sequences for CARD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BXL7
  • Contains 1 CARD domain.
  • Contains 1 guanylate kinase-like domain.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with CARD11: view

No data available for Gene Families for CARD11 Gene

Function for CARD11 Gene

Molecular function for CARD11 Gene

UniProtKB/Swiss-Prot Function: Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10

Gene Ontology (GO) - Molecular Function for CARD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004385 guanylate kinase activity NAS 11278692
GO:0005515 protein binding IPI 16809782
GO:0050700 CARD domain binding IPI 11278692
genes like me logo Genes that share ontologies with CARD11: view
genes like me logo Genes that share phenotypes with CARD11: view

Animal Models for CARD11 Gene

MGI Knock Outs for CARD11:

Animal Model Products

CRISPR Products

miRNA for CARD11 Gene

miRTarBase miRNAs that target CARD11

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CARD11 Gene

Localization for CARD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD11 Gene

Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.

Subcellular locations from

Jensen Localization Image for CARD11 Gene COMPARTMENTS Subcellular localization image for CARD11 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CARD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005737 cytoplasm IDA 12154360
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0042101 colocalizes_with T cell receptor complex IDA 12154360
genes like me logo Genes that share ontologies with CARD11: view

Pathways for CARD11 Gene

genes like me logo Genes that share pathways with CARD11: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CARD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IMP 12154360
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0007165 signal transduction --
GO:0030890 positive regulation of B cell proliferation IEA --
GO:0031295 T cell costimulation IDA 17287217
genes like me logo Genes that share ontologies with CARD11: view

Compounds for CARD11 Gene

(2) Novoseek inferred chemical compound relationships for CARD11 Gene

Compound -log(P) Hits PubMed IDs
guanylate 68.4 7
lipid 16 3
genes like me logo Genes that share compounds with CARD11: view

Transcripts for CARD11 Gene

Unigene Clusters for CARD11 Gene

Caspase recruitment domain family, member 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CARD11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CARD11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a ·
SP1: - - -
SP2: -

ExUns: 22b ^ 23 ^ 24 ^ 25 ^ 26

Relevant External Links for CARD11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARD11 Gene

mRNA expression in normal human tissues for CARD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CARD11 Gene

This gene is overexpressed in Whole Blood (12.0), Spleen (8.1), and Small Intestine - Terminal Ileum (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARD11 Gene

SOURCE GeneReport for Unigene cluster for CARD11 Gene Hs.648101

mRNA Expression by UniProt/SwissProt for CARD11 Gene

Tissue specificity: Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitts lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.
genes like me logo Genes that share expressions with CARD11: view

In Situ Assay Products

Orthologs for CARD11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CARD11 35
  • 99.36 (n)
  • 99.83 (a)
CARD11 36
  • 100 (a)
(Bos Taurus)
Mammalia CARD11 35
  • 89.91 (n)
  • 93.54 (a)
CARD11 36
  • 94 (a)
(Canis familiaris)
Mammalia CARD11 35
  • 89.37 (n)
  • 94.02 (a)
CARD11 36
  • 94 (a)
(Mus musculus)
Mammalia Card11 35
  • 87 (n)
  • 92.11 (a)
Card11 16
Card11 36
  • 92 (a)
(Monodelphis domestica)
Mammalia CARD11 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
-- 36
  • 95 (a)
(Rattus norvegicus)
Mammalia LOC100363332 35
  • 84.07 (n)
  • 87.99 (a)
(Gallus gallus)
Aves CARD11 35
  • 75.34 (n)
  • 80.07 (a)
CARD11 36
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
-- 36
  • 74 (a)
(Danio rerio)
Actinopterygii card11 36
  • 66 (a)
LOC557072 35
  • 67.45 (n)
  • 67.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for CARD11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD11 Gene

Gene Tree for CARD11 (if available)
Gene Tree for CARD11 (if available)

Paralogs for CARD11 Gene

Paralogs for CARD11 Gene

Selected SIMAP similar genes for CARD11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CARD11: view

Variants for CARD11 Gene

Sequence variations from dbSNP and Humsavar for CARD11 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs746008 -- 2,955,172(+) CACAG(C/T)GGCTC intron-variant
rs746009 -- 2,955,230(+) aacca(G/T)agagc intron-variant
rs958331 -- 2,921,775(+) GAGTC(C/T)TGGCC intron-variant
rs1124581 -- 2,906,827(+) TCAGG(C/T)CGGGG reference, synonymous-codon
rs1182132 -- 2,949,447(-) aaaaa(G/T)taact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARD11 Gene

Variant ID Type Subtype PubMed ID
nsv526132 CNV Loss 19592680
nsv887316 CNV Loss 21882294
esv2233828 CNV Deletion 18987734
esv2733865 CNV Deletion 23290073
nsv528122 CNV Loss 19592680
esv2733866 CNV Deletion 23290073
esv2733867 CNV Deletion 23290073
esv21606 CNV Loss 19812545
nsv464260 CNV Gain 19166990
esv2733868 CNV Deletion 23290073
esv2733869 CNV Deletion 23290073
nsv366076 CNV Insertion 16902084
esv2660422 CNV Deletion 23128226

Relevant External Links for CARD11 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD11 Gene

Disorders for CARD11 Gene

(2) OMIM Diseases for CARD11 Gene (607210)


  • Persistent polyclonal B-cell lymphocytosis (PPBL) [MIM:606445]: An autosomal dominant condition characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy. {ECO:0000269 PubMed:23129749}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Immunodeficiency 11 (IMD11) [MIM:615206]: An autosomal recessive primary immunodeficiency characterized by normal numbers of T and B-lymphocytes, but defective intracellular signaling. There is a block in B-cell differentiation with increased numbers of transitional B-cells and hypogammaglobulinemia, as well as decreased numbers of regulatory T-cells and defects in T-cell function. {ECO:0000269 PubMed:23374270}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CARD11 Gene

(3) Novoseek inferred disease relationships for CARD11 Gene

Disease -log(P) Hits PubMed IDs
malt lymphoma 61.8 3
lymphoma 40.2 2
lymphoma b-cell 38 4

Relevant External Links for CARD11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CARD11: view

Publications for CARD11 Gene

  1. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. (PMID: 11356195) Gaide O. … Tschopp J. (FEBS Lett. 2001) 2 3 4 23
  2. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB. (PMID: 11278692) Bertin J. … Alnemri E.S. (J. Biol. Chem. 2001) 2 3 4
  3. The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association. (PMID: 18625728) McCully R.R. … Pomerantz J.L. (Mol. Cell. Biol. 2008) 3 23
  4. PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. (PMID: 16301747) Shinohara H. … Kurosaki T. (J. Exp. Med. 2005) 3 23
  5. CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. (PMID: 16508008) Narayan P. … Kane L.P. (Mol. Cell. Biol. 2006) 3 23

Products for CARD11 Gene

Sources for CARD11 Gene

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