Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CARD11 Gene

protein-coding GIFtS: 64
GCID: GC07M002912

caspase recruitment domain family, member 11

Explore 18 diseases affiliated with
CARD11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Caspase Recruitment Domain Family, Member 11¹ ²		CARD-Containing MAGUK Protein 1² ³
CARMA1¹ ² ³ ⁵		Bcl10-Interacting Maguk Protein 3²
BIMP3¹ ² ⁵		Card-Maguk Protein 1²
Carma 1² ³		Caspase Recruitment Domain-Containing Protein 11²

External Ids:	HGNC: 16393¹	Entrez Gene: 84433²	Ensembl: ENSG00000198286⁷	OMIM: 607210⁵	UniProtKB: Q9BXL7³

Export aliases for CARD11 gene to outside databases

Previous GC identifers: GC07M002590 GC07M002690 GC07M002719

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CARD11:

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of

proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of

the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a

characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of

CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known

to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein

activated NF-kappaB and induced the phosphorylation of BCL10. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAR11_HUMAN, Q9BXL7

Function: Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its

binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner.

Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10

Gene Wiki entry for CARD11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CARD11 gene promoter:
STAT1 AML1a AP-1 ATF-2 STAT1beta Lmo2 STAT1alpha STAT2 c-Jun NF-kappaB1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CARD11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22 Ensembl cytogenetic band: 7p22.2 HGNC cytogenetic band: 7p22

CARD11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD11 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M002912: view genomic region (about GC identifiers)

Start:	2,945,769 bp from pter	End:	3,083,579 bp from pter
Size:	137,811 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 2,993,639-3,131,460

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAR11_HUMAN, Q9BXL7 (See protein sequence)

Recommended Name: Caspase recruitment domain-containing protein 11

Size: 1154 amino acids; 133284 Da

Subunit: Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to

each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail)

Subcellular location: Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts

Caution: Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART

Sequence caution: Sequence=AAG53402.1; Type=Erroneous initiation; Sequence=AAI11720.2; Type=Erroneous initiation;

Sequence=AAQ96893.1; Type=Erroneous gene model prediction; Sequence=EAL23962.1; Type=Erroneous gene model prediction;

Secondary accessions: A4D1Z7 Q2NKN7 Q548H3

Explore the universe of human proteins at neXtProt for CARD11: NX_Q9BXL7

Post-translational modifications:

Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form

that activates the NF-kappa-B signaling (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BXL7

CARD11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115791.3

ENSEMBL proteins:

ENSP00000380150 ENSP00000347695 ENSP00000348779

Reactome Protein details: Q9BXL7
Human Recombinant Protein Products for CARD11:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CARD11 OriGene Custom Protein Services for CARD11
	GenScript Custom Purified and Recombinant Proteins Services for CARD11
	Novus Biologicals CARD11 Proteins Novus Biologicals CARD11 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CARD11

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IDA	12154360
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0042101	colocalizes with T cell receptor complex	IDA	12154360

CARD11 for ontologies About GeneDecksing

CARD11 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CARD11
	R&D Systems Antibodies for CARD11 (CARD11/CARMA1)
	Cell Signaling Technology (CST) Antibodies for CARD11
	OriGene Antibodies (see all 3): CARD11 OriGene Custom Antibody Services for CARD11
	GenScript Custom Superior Antibodies Services for CARD11
	Novus Biologicals CARD11 Antibodies
	Abcam antibodies for CARD11
	Uscn Antibodies for CARD11
	ThermoFisher Antibody for CARD11

Assay Products for CARD11:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CARD11
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CARD11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CARD11 for domains About GeneDecksing

3 InterPro domains/families:

IPR011029 DEATH-like_dom

IPR001478 PDZ

IPR001315 CARD

Graphical View of Domain Structure for InterPro Entry Q9BXL7

ProtoNet protein and cluster: Q9BXL7

2 Blocks protein families:

IPB001315 CARD interaction domain

IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: CAR11_HUMAN, Q9BXL7

Similarity: Contains 1 CARD domain

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 1 PDZ (DHR) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CAR11_HUMAN, Q9BXL7

Function: Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its

binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner.

Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004385	guanylate kinase activity	NAS	11278692
GO:0005515	protein binding	IPI	17287217
GO:0050700	CARD domain binding	IPI	11278692

CARD11 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CARD11:

Decreased circadian period len

6 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Card11):

cellular	hematopoietic system	homeostasis/metabolism	immune system	integument
respiratory system

CARD11 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CARD11: Card11^tm1Xav Card11^tm1Litt Card11^tm1Pngr

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CARD11

miRNA Products:		OriGene 3'-UTR Clone: CARD11 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARD11
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CARD11:
		hsa-miR-181c hsa-miR-4272 hsa-miR-181a hsa-miR-181d hsa-miR-661 hsa-miR-155 hsa-miR-4262 hsa-miR-181b

		SwitchGear 3'UTR luciferase reporter plasmid: CARD11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD11 (see all 4) OriGene shRNA RFP: CARD11 OriGene siRNA: CARD11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD11
		Sirion Biotech Custom design and validation of potent shRNA sequences against CARD11

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CARD11
			Sirion Biotech Customized adenovirus for overexpression of CARD11 Sirion Biotech Customized adenovirus for potent knockdown of CARD11

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD11 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CARD11 (NM_032415)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CARD11
		Search LifeMap BioReagents cell lines for CARD11
		Sirion Biotech Customized stable knockdown cell line services for CARD11 Sirion Biotech Customized inducible knockdown cell line services for CARD11 Sirion Biotech Customized stable overexpressing cell line services for CARD11 Sirion Biotech Customized inducible overexpressing cell line services for CARD11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD11

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

B cell receptor signaling pathway

	B cell receptor signaling pathway	1.00			T cell receptor signaling pathway	0.40
	BCR signaling pathway	0.41			TCR Signaling Pathway	0.19

Immune System

Immune System

1.00

Adaptive Immune System

0.59

TCR signaling

TCR signaling

1.00

Downstream TCR signaling

0.75

Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)

1.00

Downstream Signaling Events Of B Cell Receptor (BCR)

0.81

Immune response T cell receptor signaling pathway

Immune response T cell receptor signaling pathway

1.00

Immune response_T cell receptor signaling pathway

0.88

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CARD11

Immune response T cell receptor signaling pathway

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CARD11

	PKC-Theta Pathway
	TCR Signaling
	CD28 Signaling in T-Helper Cell
	NF-KappaB Family Pathway

2 Cell Signaling Technology (CST) Pathways for CARD11

	Lymphocyte Signaling
	NF-kappaB Signaling

1 GeneGo (Thomson Reuters) Pathway for CARD11

Immune response T cell receptor signaling pathway

5 BioSystems Pathways for CARD11

	B Cell Receptor Signaling Pathway
	TCR Signaling Pathway
	BCR signaling pathway
	TCR signaling in naive CD4+ T cells
	TCR signaling in naive CD8+ T cells

5/10 Reactome Pathways for CARD11 (see all 10)

	Adaptive Immune System
	Activation of NF-kappaB in B Cells
	Signaling by the B Cell Receptor (BCR)
	Phosphorylation of CARMA1 in B Cells
	Downstream TCR signaling

2 Kegg Pathways (Kegg details for CARD11):

	T cell receptor signaling pathway
	B cell receptor signaling pathway

CARD11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CARD11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/31 Interacting proteins for CARD11 (Q9BXL7^{2, 3} ENSP00000380150⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MALT1	Q9UDY8²^,³, ENSP00000319279⁴	MINT-6177529 MINT-6177640 MINT-8143041 I2D: score=1 STRING: ENSP00000319279
COPS5	Q92905²^,³, ENSP00000350512⁴	MINT-7228563 MINT-7228732 I2D: score=3 STRING: ENSP00000350512
PDPK1	O15530²^,³, ENSP00000344220⁴	MINT-8265511 I2D: score=4 STRING: ENSP00000344220
TAB1	Q15750²^,³, ENSP00000216160⁴	MINT-8260031 I2D: score=2 STRING: ENSP00000216160
BCL10	O95999²^,³, ENSP00000271015⁴	MINT-7228715 MINT-6177529 MINT-8143014 MINT-8143041 I2D: score=6 STRING: ENSP00000271015

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001819	positive regulation of cytokine production	IMP	12154360
GO:0007165	signal transduction	--	--
GO:0030890	positive regulation of B cell proliferation	IEA	--
GO:0031295	T cell costimulation	IDA	17287217
GO:0042102	positive regulation of T cell proliferation	IEA	--

CARD11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CARD11 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CARD11
2 Novoseek chemical compound relationships for CARD11 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	68.4	9	16177990 (2), 15520247 (1), 15598810 (1), 17395537 (1) (see all 6)
lipid	16	3	15598810 (1), 14754896 (1), 15802604 (1)

Search CenterWatch for drugs/clinical trials and news about CARD11 / CAR11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CARD11 gene:

NM_032415.4

Unigene Cluster for CARD11:

Caspase recruitment domain family, member 11

Hs.648101 [show with all ESTs]

Unigene Representative Sequence: NM_032415

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000396946(uc003smv.3) ENST00000480332 ENST00000355508 ENST00000356408

miRNA Products:		OriGene 3'-UTR Clone: CARD11 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARD11
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CARD11:
		hsa-miR-181c hsa-miR-4272 hsa-miR-181a hsa-miR-181d hsa-miR-661 hsa-miR-155 hsa-miR-4262 hsa-miR-181b

		SwitchGear 3'UTR luciferase reporter plasmid: CARD11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD11 (see all 4) OriGene shRNA RFP: CARD11 OriGene siRNA: CARD11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD11
		Sirion Biotech Custom design and validation of potent shRNA sequences against CARD11

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD11 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CARD11 (NM_032415)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD11

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CARD11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD11

Additional cDNA sequence:

AF322641.1 AF352576.1 AK056847.1 AK074049.1 AK098010.1 BC111719.1

5 DOTS entries:

DT.207933 DT.95197077 DT.95278889 DT.99929855 DT.100000082

24/94 AceView cDNA sequences (see all 94):

BQ058537 CA454032 AF352576 BQ058504 AK074049 BQ058355 AA194010 BQ056689

BQ002323 BQ961067 AW512325 AA179931 AI469971 BF732581 BQ642414 AW296670

BQ059470 BE513331 CF136037 AF322641 AI440314 AI910864 AK098010 BX391705

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CARD11 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^	20a	·	20b	^	21	^	22a	·
SP1:					-																																-								-
SP2:																																													-
SP3:
SP4:

ExUns:	22b	^	23	^	24	^	25	^	26
SP1:
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for CARD11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CARD11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCGCCAG

About this image
See CARD11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CARD11

SOURCE GeneReport for Unigene cluster: Hs.648101

UniProtKB/Swiss-Prot: CAR11_HUMAN, Q9BXL7

Tissue specificity: Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in

promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and

colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells

SABiosciences Expression via Pathway-Focused PCR Arrays including CARD11:

NFKB Signaling Pathway in human mouse rat

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CARD11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD11

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CARD11 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CARD11¹	caspase recruitment domain family, member 11	75.34(n) 80.07(a)		416476 NM_001006161.2 NP_001006161.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	87(a) 60(a)	1 ↔ many 1 ↔ many	AAWZ02038711(6971-9159) GL343340.1(451284-511330)
zebrafish (Danio rerio)	Actinopterygii	LOC557072¹	caspase recruitment domain-containing protein 11-like	64.36(n) 62.34(a)		557072 XM_680052.5 XP_685144.5

ENSEMBL Gene Tree for CARD11 (if available)
TreeFam Gene Tree for CARD11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CARD11 gene

CARD14² CARD10² CARD9²

2 SIMAP similar genes for CARD11 using alignment to 3 protein entries: CAR11_HUMAN (see all proteins):

FLJ00120 CARD14

CARD11 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28680587^1,2	F	--	2901683(+)	`AAAAAG/AAAAGA`	1	--	int¹ trp³		2		NA	4
rs6959334^1,2	C,F,A,H	--	2943726(+)	`TGTGCG/ATGAGC`	1	--	int¹		15		NS EA NA WA	2060
rs188416303^1,2		--	2945262(+)	`CGGGCC/GTGGCT`	1	--	ds500¹		0	--	--	--	--
rs2679253^1,2	C,F,A	--	2945342(-)	`CAGGTC/AAGGAG`	1	--	ds500¹		8		NA CSA WA EA	368
rs41415151^1,2	C,F	--	2945378(+)	`GGGACA/GTTGAA`	1	--	ds500¹		1		EA	120
rs41461253^1,2	C	--	2945379(+)	`GGACAC/TTGAAT`	1	--	ds500¹		0	--	--	--	--
rs137974081^1,2		--	2945390(+)	`GTGGGC/GCAGGG`	1	--	ds500¹		0	--	--	--	--
rs185775353^1,2		--	2945515(+)	`CTTCTA/CAGGGT`	1	--	ds500¹		0	--	--	--	--
rs189503582^1,2		--	2945591(+)	`TATTAC/TCCTAA`	1	--	ds500¹		0	--	--	--	--
rs181045062^1,2		--	2945835(+)	`TTCCCC/TGATCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CARD11 (2945769 - 3083579 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CARD11
2 Indels: 69771 47334

4 SABiosciences Cancer Mutation PCR Assays for CARD11:

Cosmic Id	AA Change
41657	p.D223N
41656	p.T121M
85863	p.G119D
41659	p.L244P

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD11

DNA2.0 Custom Variant and Variant Library Synthesis for CARD11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CARD11 for disorders           About GeneDecksing

OMIM gene information: 607210    OMIM disorders: --

18 diseases for CARD11:    About MalaCards

diffuse large b-cell lymphoma b-cell lymphomas common variable immunodeficiency malt lymphoma

allergic asthma burkitt's lymphoma hodgkin's lymphoma multiple myeloma

hepatitis b asthma acute leukemia myeloma

immunodeficiency hepatitis leukemia adenocarcinoma

cns lymphoma sepsis

1 disease from the University of Copenhagen DISEASES database for CARD11:

Lymphoma

3 Novoseek disease relationships for CARD11 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malt lymphoma	61.8	9	16177990 (3)
lymphoma	40.2	2	16177990 (2)
lymphoma b-cell	38	6	16177990 (3), 15598810 (1)

Genetic Association Database (GAD): CARD11
Human Genome Epidemiology (HuGE) Navigator: CARD11 (4 documents)

Export disorders for CARD11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CARD11 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with CARD11)

Utopia: connect your pdf to the dynamic
world of online information

Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. (PubMed id 11356195)^{1, 2, 3, 9} Gaide O.... Tschopp J. (2001)
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB. (PubMed id 11278692)^{1, 2, 3} Bertin J.... Alnemri E.S. (2001)
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. (PubMed id 17287217)^{1, 2} Ohnuma K....Morimoto C. (2007)
Mutations of genes involved in the innate immune system as predictors of sepsis in very low birth weight infants. (PubMed id 14739370)^{1, 4} Ahrens P....Gopel W. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association. (PubMed id 18625728)^{1, 9} McCully R.R. and Pomerantz J.L. (2008)
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. (PubMed id 16301747)^{1, 9} Shinohara H....Kurosaki T. (2005)
CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. (PubMed id 16508008)^{1, 9} Narayan P....Kane L.P. (2006)
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. (PubMed id 15802604)^{1, 9} Lee K.Y....Ghosh S. (2005)
A quantitative signaling screen identifies CARD11 muta tions in the CARD and LATCH domains that induce Bcl10 ubiquitination and human l ymphoma cell survival. (PubMed id 23149938)¹ Chan W....Pomerantz J.L. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84433	HGNC: 16393	AceView: CARD11	Ensembl:ENSG00000198286	euGenes: HUgn84433
ECgene: CARD11	Kegg: 84433	H-InvDB: CARD11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CARD11	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CARD11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CARD11 gene:
Search GeneIP for patents involving CARD11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of CARD11
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CARD11 (CARD11/CARMA1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for CARD11		OriGene shRNA RFP for CARD11
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD11		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD11
	OriGene Protein Over-expression Lysate for CARD11		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CARD11		OriGene 3'-UTR Clone for CARD11
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD11		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD11
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CARD11		OriGene Custom Protein Services for CARD11
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CARD11
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD11
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD11
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD11
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD11
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD11

	GenScript Custom Purified and Recombinant Proteins Services for CARD11		GenScript cDNA clones with any tag delivered in your preferred vector for CARD11
	GenScript Custom Assay Services for CARD11		GenScript Custom Superior Antibodies Services for CARD11
	GenScript Custom overexpressing Cell Line Services for CARD11		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for CARD11

	Regulatory tfbs in CARD11 promoter
	Search Chromatin IP Primers for CARD11
	RT² qPCR Primer Assay in human, mouse, rat CARD11
	GNC Network for CARD11
	SABiosciences PCR Arrays including human, mouse, rat CARD11

Search Tocris compounds for CARD11

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CARD11 antibodies
	CARD11 proteins
	CARD11 lysates

	Antibodies for CARD11
	See all of Abcam's Antibodies, Kits and Proteins for CARD11
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CARD11 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CARD11

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD11

	SwitchGear 3'UTR luciferase reporter plasmids for CARD11
	Browse SwitchGear Promoter luciferase reporter plasmids for CARD11

ThermoFisher Antibody for CARD11

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD11

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CARD11

Sirion Biotech Customized:

	stable knockdown cell line services for CARD11
	inducible knockdown cell line services for CARD11
	design and validation of potent shRNA sequences against CARD11
	adenovirus for potent knockdown of CARD11
	adenovirus for overexpression of CARD11
	stable overexpressing cell line services for CARD11
	inducible overexpressing cell line services for CARD11

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CARD11 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CARD11 Gene

caspase recruitment domain family, member 11

Aliases
for CARD11 gene

Summaries
for CARD11 gene

Genomic Views
for CARD11 gene

Proteins
for CARD11 gene

Protein Domains /
Families
for CARD11 gene

Function
for CARD11 gene

Pathways & Interactions
for CARD11 gene

Drugs & Compounds
for CARD11 gene

Transcripts
for CARD11 gene

Expression
for CARD11 gene

Orthologs
for CARD11 gene

Paralogs
for CARD11 gene

Genomic Variants
for CARD11 gene

Disorders / Diseases
for CARD11 gene

Publications
for CARD11 gene

External Searches for CARD11 gene

Genome Databases showing CARD11 gene

Other Databases showing CARD11 gene

Specialized Databases showing CARD11 gene

Intellectual Property
for CARD11 gene

Products
for CARD11 gene

View Random Gene

Advanced Search

Export list of displayed genes

CARD11 Gene

caspase recruitment domain family, member 11

Aliasesfor CARD11 gene

Summariesfor CARD11 gene

Genomic Viewsfor CARD11 gene

Proteinsfor CARD11 gene

Protein Domains /Familiesfor CARD11 gene

Functionfor CARD11 gene

Pathways & Interactionsfor CARD11 gene

Drugs & Compoundsfor CARD11 gene

Transcriptsfor CARD11 gene

Expression for CARD11 gene

Orthologsfor CARD11 gene

Paralogsfor CARD11 gene

Genomic Variantsfor CARD11 gene

Disorders / Diseasesfor CARD11 gene

Publicationsfor CARD11 gene

External Searches for CARD11 gene

Genome Databases showing CARD11 gene

Other Databases showing CARD11 gene

Specialized Databases showing CARD11 gene

Intellectual Propertyfor CARD11 gene

Productsfor CARD11 gene

View Random Gene

Aliases
for CARD11 gene

Summaries
for CARD11 gene

Genomic Views
for CARD11 gene

Proteins
for CARD11 gene

Protein Domains /
Families
for CARD11 gene

Function
for CARD11 gene

Pathways & Interactions
for CARD11 gene

Drugs & Compounds
for CARD11 gene

Transcripts
for CARD11 gene

Expression
for CARD11 gene

Orthologs
for CARD11 gene

Paralogs
for CARD11 gene

Genomic Variants
for CARD11 gene

Disorders / Diseases
for CARD11 gene

Publications
for CARD11 gene

Intellectual Property
for CARD11 gene

Products
for CARD11 gene