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Aliases for CARD10 Gene

Aliases for CARD10 Gene

  • Caspase Recruitment Domain Family Member 10 2 3 5
  • Caspase Recruitment Domain Family, Member 10 2 3
  • CARD-Containing MAGUK Protein 3 3 4
  • Carma 3 3 4
  • CARMA3 3 4
  • Bcl10 Binding Protein And Activator Of NFKB 3
  • CARD-Containing MAGUK 3 Protein 3
  • BIMP1 3

External Ids for CARD10 Gene

Previous GeneCards Identifiers for CARD10 Gene

  • GC22M034500
  • GC22M036129
  • GC22M036210
  • GC22M037886
  • GC22M020852
  • GC22M037491
  • GC22M038419

Summaries for CARD10 Gene

Entrez Gene Summary for CARD10 Gene

  • The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CARD10 Gene

CARD10 (Caspase Recruitment Domain Family Member 10) is a Protein Coding gene. Among its related pathways are GPCR Pathway and TCR Signaling (Qiagen). GO annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is CARD11.

UniProtKB/Swiss-Prot for CARD10 Gene

  • Activates NF-kappa-B via BCL10 and IKK.

Gene Wiki entry for CARD10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD10 Gene

Genomics for CARD10 Gene

Regulatory Elements for CARD10 Gene

Enhancers for CARD10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CARD10 on UCSC Golden Path with GeneCards custom track

Promoters for CARD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CARD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CARD10 Gene

37,490,362 bp from pter
37,519,542 bp from pter
29,181 bases
Minus strand

Genomic View for CARD10 Gene

Genes around CARD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD10 Gene

Proteins for CARD10 Gene

  • Protein details for CARD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caspase recruitment domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • Q14CQ8
    • Q5TFG6
    • Q8NC81
    • Q9UGR5
    • Q9UGR6
    • Q9Y3H0

    Protein attributes for CARD10 Gene

    1032 amino acids
    Molecular mass:
    115931 Da
    Quaternary structure:
    • CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).

    Alternative splice isoforms for CARD10 Gene


neXtProt entry for CARD10 Gene

Proteomics data for CARD10 Gene at MOPED

Post-translational modifications for CARD10 Gene

  • Ubiquitination at Lys 778
  • Modification sites at PhosphoSitePlus

Other Protein References for CARD10 Gene

No data available for DME Specific Peptides for CARD10 Gene

Domains & Families for CARD10 Gene

Protein Domains for CARD10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CARD domain.
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with CARD10: view

Function for CARD10 Gene

Molecular function for CARD10 Gene

UniProtKB/Swiss-Prot Function:
Activates NF-kappa-B via BCL10 and IKK.

Phenotypes for CARD10 Gene

genes like me logo Genes that share phenotypes with CARD10: view

Animal Models for CARD10 Gene

MGI Knock Outs for CARD10:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARD10 Gene

Localization for CARD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD10 Gene


Subcellular locations from

Jensen Localization Image for CARD10 Gene COMPARTMENTS Subcellular localization image for CARD10 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CARD10 Gene

Pathways & Interactions for CARD10 Gene

genes like me logo Genes that share pathways with CARD10: view

Pathways by source for CARD10 Gene

Gene Ontology (GO) - Biological Process for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007250 activation of NF-kappaB-inducing kinase activity ISS 11259443
genes like me logo Genes that share ontologies with CARD10: view

No data available for SIGNOR curated interactions for CARD10 Gene

Drugs & Compounds for CARD10 Gene

No Compound Related Data Available

Transcripts for CARD10 Gene

Unigene Clusters for CARD10 Gene

Caspase recruitment domain family, member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CARD10 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^
SP1: - -
SP3: -
SP4: - - - -
SP7: - - -
SP9: -
SP11: -

ExUns: 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1: -
SP2: -
SP8: -

Relevant External Links for CARD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARD10 Gene

mRNA expression in normal human tissues for CARD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CARD10 Gene

This gene is overexpressed in Plasma (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CARD10 Gene

SOURCE GeneReport for Unigene cluster for CARD10 Gene Hs.57973

mRNA Expression by UniProt/SwissProt for CARD10 Gene

Tissue specificity: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.
genes like me logo Genes that share expression patterns with CARD10: view

Protein tissue co-expression partners for CARD10 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CARD10 Gene

Orthologs for CARD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CARD10 35
  • 90.08 (n)
  • 93.47 (a)
CARD10 36
  • 93 (a)
(Canis familiaris)
Mammalia CARD10 35
  • 90.04 (n)
  • 93.44 (a)
CARD10 36
  • 68 (a)
(Mus musculus)
Mammalia Card10 35
  • 86.71 (n)
  • 91.77 (a)
Card10 16
Card10 36
  • 87 (a)
(Pan troglodytes)
Mammalia CARD10 35
  • 99.19 (n)
  • 99.41 (a)
CARD10 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Card10 35
  • 85.78 (n)
  • 91.27 (a)
(Monodelphis domestica)
Mammalia CARD10 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia CARD10 36
  • 74 (a)
(Gallus gallus)
Aves CARD10 35
  • 71.14 (n)
  • 70.11 (a)
CARD10 36
  • 61 (a)
(Anolis carolinensis)
Reptilia CARD10 36
  • 56 (a)
(Danio rerio)
Actinopterygii CARD10 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for CARD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD10 Gene

Gene Tree for CARD10 (if available)
Gene Tree for CARD10 (if available)

Paralogs for CARD10 Gene

Paralogs for CARD10 Gene

(1) SIMAP similar genes for CARD10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CARD10: view

Variants for CARD10 Gene

Sequence variations from dbSNP and Humsavar for CARD10 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs9610775 - 37,510,255(+) TCAGC(C/T)GCTGG reference, missense
rs2092170 -- 37,510,880(+) agttt(A/G)agacc intron-variant
rs2092171 -- 37,510,936(+) aatga(C/G)ctggg intron-variant
rs2092172 -- 37,511,062(+) gggca(A/G)cagag intron-variant
rs2103577 -- 37,514,605(+) ATATC(A/G)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARD10 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv915028 CNV Loss 21882294
esv2496764 CNV Insertion 19546169
nsv512657 CNV Loss 21212237
esv3438 CNV Deletion 18987735
esv2724214 CNV Deletion 23290073
esv5893 CNV Loss 19470904
esv1010487 CNV Deletion 20482838
esv2724215 CNV Deletion 23290073
esv1582981 CNV Deletion 17803354
esv2724216 CNV Deletion 23290073

Variation tolerance for CARD10 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.40; 88.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARD10 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD10 Gene

Disorders for CARD10 Gene

Relevant External Links for CARD10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CARD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD10 Gene

Publications for CARD10 Gene

  1. CARD10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with Bcl10 and activates NF-kappa B. (PMID: 11259443) Wang L. … Bertin J. (J. Biol. Chem. 2001) 2 3 4 67
  2. CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. (PMID: 18757306) Medoff B.D. … Xavier R.J. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23
  3. A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-kappaB. (PMID: 18349075) Stilo R. … Vito P. (J. Cell. Sci. 2008) 3 23
  4. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. (PMID: 11356195) Gaide O. … Tschopp J. (FEBS Lett. 2001) 2 3
  5. CARMA3 Represses Metastasis-Suppressor NME2 to Promote Lung Cancer Stemness and Metastasis. (PMID: 25906011) Chang Y.W. … Su J.L. (Am. J. Respir. Crit. Care Med. 2015) 3

Products for CARD10 Gene

Sources for CARD10 Gene