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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CARD10 Gene

protein-coding GIFtS: 56
GCID: GC22M037886

caspase recruitment domain family, member 10

Explore 8 diseases affiliated with
CARD10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Caspase Recruitment Domain Family, Member 10¹ ²		CARD-Containing MAGUK Protein 3² ³
CARMA3¹ ² ³ ⁵		Bcl10 Binding Protein And Activator Of NFKB²
BIMP1¹ ² ⁵		CARD-Containing MAGUK 3 Protein²
Carma 3² ³		Caspase Recruitment Domain-Containing Protein 10²

External Ids:	HGNC: 16422¹	Entrez Gene: 29775²	Ensembl: ENSG00000100065⁷	OMIM: 607209⁵	UniProtKB: Q9BWT7³

Export aliases for CARD10 gene to outside databases

Previous GC identifers: GC22M034500 GC22M036129 GC22M036210 GC22M020852

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CARD10:

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It

participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several

other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates

NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 (PubMed 11259443)).(supplied by OMIM,

Mar 2008)

UniProtKB/Swiss-Prot: CAR10_HUMAN, Q9BWT7

Function: Activates NF-kappa-B via BCL10 and IKK

Gene Wiki entry for CARD10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CARD10 gene promoter:
GR GR-beta Olf-1 NF-E2 p45 c-Ets-1 HEN1 Pax-3 GR-alpha ZID NF-E2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CARD10 promoter sequence

Search SABiosciences Chromatin IP Primers for CARD10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CARD10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

CARD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD10 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M037886: view genomic region (about GC identifiers)

Start:	37,886,400 bp from pter	End:	37,915,549 bp from pter
Size:	29,150 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAR10_HUMAN, Q9BWT7 (See protein sequence)

Recommended Name: Caspase recruitment domain-containing protein 10

Size: 1032 amino acids; 115931 Da

Subunit: CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1,

where MALT1 binds to BCL10 (By similarity)

Subcellular location: Cytoplasm (By similarity)

Caution: Supposed to contain a SH3, a PDZ and a guanylate kinase-like domain. But none of these 3 domains are detected

by PROSITE, Pfam or SMART

Secondary accessions: Q14CQ8 Q5TFG6 Q9UGR5 Q9UGR6 Q9Y3H0

Explore the universe of human proteins at neXtProt for CARD10: NX_Q9BWT7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BWT7

CARD10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055365.2

ENSEMBL proteins:

ENSP00000384570 ENSP00000385799 ENSP00000251973 ENSP00000416239 ENSP00000393411

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CARD10 Proteins Novus Biologicals CARD10 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CARD10

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	11259443
GO:0032449	CBM complex	NAS	15125833

CARD10 for ontologies About GeneDecksing

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	Uscn Antibodies for CARD10
	ThermoFisher Antibodies for CARD10

Assay Products for CARD10:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CARD10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CARD10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CARD10 for domains About GeneDecksing

2 InterPro domains/families:

IPR011029 DEATH-like_dom

IPR001315 CARD

Graphical View of Domain Structure for InterPro Entry Q9BWT7

ProtoNet protein and cluster: Q9BWT7

1 Blocks protein family: IPB001315 CARD interaction domain

UniProtKB/Swiss-Prot: CAR10_HUMAN, Q9BWT7

Similarity: Contains 1 CARD domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CAR10_HUMAN, Q9BWT7

Function: Activates NF-kappa-B via BCL10 and IKK

miRNA Products:		OriGene 3'-UTR Clone: CARD10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARD10
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CARD10 (see all 14):
		hsa-miR-146a hsa-miR-15a hsa-miR-2278 hsa-miR-1301 hsa-miR-497 hsa-miR-424 hsa-miR-19b hsa-miR-143*

		SwitchGear 3'UTR luciferase reporter plasmid: CARD10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD10 (see all 7) OriGene shRNA RFP: CARD10 OriGene siRNA: CARD10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CARD10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CARD10 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CARD10 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CARD10 (NM_014550)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CARD10
		Search LifeMap BioReagents cell lines for CARD10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD10

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11259443
GO:0030159	receptor signaling complex scaffold activity	NAS	11259443

CARD10 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CARD10:

Elongated cells

Animal Models:
Mouse knock-out Card10^tm1Xlin for CARD10
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Card10):

mortality/aging

nervous system

CARD10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PKC-Theta Pathway

PKC-Theta Pathway

1.00

NF-KappaB Family Pathway

NF-KappaB Family Pathway

1.00

GPCR Pathway

GPCR Pathway

1.00

B cell receptor signaling pathway

PI3K Signaling in B-Lymphocyte

0.35

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CARD10

	GPCR Pathway
	PI3K Signaling in B-Lymphocyte
	PKC-Theta Pathway
	NF-KappaB Family Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CARD10

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/533 Interacting proteins for CARD10 (Q9BWT7^{2, 3} ENSP00000251973⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 533)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCL10	O95999³, ENSP00000271015⁴	I2D: score=6 STRING: ENSP00000271015
IKBKG	Q9Y6K9³, ENSP00000358622⁴	I2D: score=3 STRING: ENSP00000358622
MALT1	Q9UDY8³, ENSP00000319279⁴	I2D: score=1 STRING: ENSP00000319279
CDC5L	Q99459², ENSP00000360532⁴	MINT-7947479 STRING: ENSP00000360532
ATXN7	O15265³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	NAS	11259443
GO:0007250	activation of NF-kappaB-inducing kinase activity	IDA	11259443
GO:0042981	regulation of apoptotic process	IEA	--

CARD10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CARD10
Search CenterWatch for drugs/clinical trials and news about CARD10 / CAR10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CARD10 gene:

NM_014550.3

Unigene Cluster for CARD10:

Caspase recruitment domain family, member 10

Hs.57973 [show with all ESTs]

Unigene Representative Sequence: AY028896

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000488141(uc003asu.1 uc011ank.1) ENST00000403299(uc003ast.1 uc003asx.1)

ENST00000467812(uc003asv.1) ENST00000406271(uc003asw.1) ENST00000251973(uc003asy.1)

ENST00000437756 ENST00000486118 ENST00000433485 ENST00000476871 ENST00000494166

miRNA Products:		OriGene 3'-UTR Clone: CARD10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CARD10
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CARD10 (see all 14):
		hsa-miR-146a hsa-miR-15a hsa-miR-2278 hsa-miR-1301 hsa-miR-497 hsa-miR-424 hsa-miR-19b hsa-miR-143*

		SwitchGear 3'UTR luciferase reporter plasmid: CARD10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CARD10 (see all 7) OriGene shRNA RFP: CARD10 OriGene siRNA: CARD10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CARD10

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		GenScript: all cDNA clones in your preferred vector: CARD10 (NM_014550)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CARD10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CARD10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD10

Additional cDNA sequence:

AF086324.1 AK074906.1 AK296176.1 AY028896.1 AY032928.1 BC032058.1 BC113659.1 BC117403.1

10 DOTS entries:

DT.309950 DT.95272280 DT.101961630 DT.100028856 DT.100028855 DT.120648630 DT.120648667 DT.91814521

DT.99971659 DT.95272279

24/113 AceView cDNA sequences (see all 113):

BU687323 AI762204 BE465866 AW137435 AW138129 AA397734 BU145814 NM_014550

BQ688908 AA513369 BE048709 AF086324 AY032928 BE221808 AW612524 BM980824

BI764337 AI948914 AW024347 AI829451 BQ690010 AI948904 BM311316 CB046689

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CARD10 (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	·	15c	^	16a	·	16b	·	16c	^	17a	·	17b	^	18a	·	18b	^
SP1:																																							-		-
SP2:
SP3:																	-
SP4:																															-		-						-		-
SP5:

ExUns:	19	^	20a	·	20b	·	20c	^	21	^	22a	·	22b	^	23	^	24a	·	24b
SP1:			-
SP2:			-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CARD10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CARD10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATGTACG

About this image

CARD10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephros

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See CARD10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CARD10

SOURCE GeneReport for Unigene cluster: Hs.57973

UniProtKB/Swiss-Prot: CAR10_HUMAN, Q9BWT7

Tissue specificity: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung.

Also found in fetal lung, liver and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including CARD10:

NFKB Signaling Pathway in human mouse rat

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CARD10 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CARD10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CARD10 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CARD10¹	caspase recruitment domain family, member 10	70.56(n) 69.07(a)		418041 XM_416277.3 XP_416277.3
lizard (Anolis carolinensis)	Reptilia	CARD10⁶	--	56(a)	1 ↔ 1	5(23490064-23547432)
zebrafish (Danio rerio)	Actinopterygii	CABZ01101968.1⁶	--	42(a)	1 ↔ 1	3(3202776-3225050)

ENSEMBL Gene Tree for CARD10 (if available)
TreeFam Gene Tree for CARD10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CARD10 gene

CARD14² CARD11² CARD9²

2 SIMAP similar genes for CARD10 using alignment to 5 protein entries: CAR10_HUMAN (see all proteins):

CARD9 FLJ00120

CARD10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190460198^1,2		--	37885960(+)	`TGGCAC/TTTCTT`	1	--	ds500¹		0	--	--	--	--
rs191284933^1,2		--	37885989(+)	`TTGCTA/CCCAGT`	1	--	ds500¹		0	--	--	--	--
rs149368046^1,2		--	37886035(+)	`AGGAAA/CCTGCG`	1	--	ds500¹		0	--	--	--	--
rs62235023^1,2		--	37886050(+)	`TACCAA/GGGGTT`	1	--	ds500¹		0	--	--	--	--
rs3180586^1,2	C	--	37886401(-)	`TCATAG/AATGCT`	1	--	ut3¹		1		NA	2
rs183520474^1,2		--	37886457(+)	`GGCCCA/GTTAAT`	1	--	ut3¹		0	--	--	--	--
rs139823002^1,2		--	37886469(+)	`ATCCAC/TGGGCC`	1	--	ut3¹		0	--	--	--	--
rs144107916^1,2		--	37886475(+)	`GGGCCA/GTACAT`	1	--	ut3¹		0	--	--	--	--
rs56174981^1,2	C,F,	--	37886499(-)	`GAGGGC/TGGCTG`	1	--	ut3¹		1		WA	118
rs188097898^1,2		--	37886514(+)	`GCCCCC/GCAAGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CARD10 (37886400 - 37915549 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CARD10
4 Indels: 43161 27050 103174 62003

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CARD10

DNA2.0 Custom Variant and Variant Library Synthesis for CARD10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CARD10 for disorders           About GeneDecksing

OMIM gene information: 607209    OMIM disorders: --

8 diseases for CARD10:    About MalaCards

reye syndrome macular degeneration multiple myeloma hepatitis b

myeloma ovarian cancer ataxia hepatitis

Human Genome Epidemiology (HuGE) Navigator: CARD10 (8 documents)

Export disorders for CARD10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CARD10 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with CARD10)

Utopia: connect your pdf to the dynamic
world of online information

CARD10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with Bcl10 and activates NF-kappa B. (PubMed id 11259443)^{1, 2, 3} Wang L.... Bertin J. (2001)
Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. (PubMed id 11356195)^{1, 2, 3} Gaide O.... Tschopp J. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. (PubMed id 18757306)^{1, 9} Medoff B.D....Xavier R.J. (2009)
A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-kappaB. (PubMed id 18349075)^{1, 9} Stilo R....Vito P. (2008)
CARMA3 is overexpressed in colon cancer and regulates NF-kB activity and cyclin D1 expression. (PubMed id 22884800)¹ Miao Z....Xu H. (2012)
Overexpression of CARMA3 in non-small-cell lung cancer is linked for tumor progression. (PubMed id 22615840)¹ Li Z....Wang E. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29775	HGNC: 16422	AceView: CARD10	Ensembl:ENSG00000100065	euGenes: HUgn29775
ECgene: CARD10	H-InvDB: CARD10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CARD10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CARD10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CARD10 gene:
Search GeneIP for patents involving CARD10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CARD10 Gene

caspase recruitment domain family, member 10

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CARD10 Gene

caspase recruitment domain family, member 10

Aliasesfor CARD10 gene

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Protein Domains /Familiesfor CARD10 gene

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