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Aliases for CARD10 Gene

Aliases for CARD10 Gene

  • Caspase Recruitment Domain Family Member 10 2 3 5
  • CARD-Containing MAGUK Protein 3 3 4
  • Carma 3 3 4
  • CARMA3 3 4
  • Caspase Recruitment Domain-Containing Protein 10 3
  • Caspase Recruitment Domain Family, Member 10 2
  • Bcl10 Binding Protein And Activator Of NFKB 3
  • CARD-Containing MAGUK 3 Protein 3
  • BIMP1 3

External Ids for CARD10 Gene

Previous GeneCards Identifiers for CARD10 Gene

  • GC22M034500
  • GC22M036129
  • GC22M036210
  • GC22M037886
  • GC22M020852
  • GC22M037491
  • GC22M038419
  • GC22M038808
  • GC22M039928

Summaries for CARD10 Gene

Entrez Gene Summary for CARD10 Gene

  • The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CARD10 Gene

CARD10 (Caspase Recruitment Domain Family Member 10) is a Protein Coding gene. Among its related pathways are TCR Signaling (Qiagen) and NF-kappa B signaling pathway. GO annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is CARD11.

UniProtKB/Swiss-Prot for CARD10 Gene

  • Activates NF-kappa-B via BCL10 and IKK.

Gene Wiki entry for CARD10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD10 Gene

Genomics for CARD10 Gene

Regulatory Elements for CARD10 Gene

Enhancers for CARD10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F037508 1.2 Ensembl ENCODE 52.5 +10.0 9985 2.6 SIN3A DMAP1 ZNF2 YY1 ZNF121 GLIS2 KLF7 FOS ZNF263 SP3 CARD10 GC22P037518 MFNG
GH22F037511 0.8 Ensembl ENCODE 9.6 +6.9 6875 2.4 ARID4B FEZF1 ZNF48 SLC30A9 GLIS2 FOS MCM3 SP5 MXD4 MIER2 LL22NC01-81G9.3 ENSG00000229971 TEX33 CARD10 GC22P037518 MFNG
GH22F037524 0.7 Ensembl ENCODE 7.8 -6.8 -6845 3.2 KLF1 ESRRA JUN INSM2 KLF17 BCL11B ZIC2 ZKSCAN1 HIC1 ZNF664 CARD10 LGALS2 ENSG00000225867
GH22F037496 0.9 Ensembl ENCODE 7.7 +18.8 18805 9.1 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ENSG00000225867 CDC42EP1 ELFN2 ENSG00000243902 CYTH4 CARD10 BAIAP2L2 MFNG GC22P037518
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CARD10 on UCSC Golden Path with GeneCards custom track

Promoters for CARD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000617985 642 2201 ELF3 ZNF76 KLF17 ARID4B DMAP1 ZNF48 RARA ZNF121 GLIS2 EGR2

Genomic Location for CARD10 Gene

37,490,362 bp from pter
37,519,542 bp from pter
29,181 bases
Minus strand

Genomic View for CARD10 Gene

Genes around CARD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD10 Gene

Proteins for CARD10 Gene

  • Protein details for CARD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caspase recruitment domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • Q14CQ8
    • Q5TFG6
    • Q8NC81
    • Q9UGR5
    • Q9UGR6
    • Q9Y3H0

    Protein attributes for CARD10 Gene

    1032 amino acids
    Molecular mass:
    115931 Da
    Quaternary structure:
    • CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).

    Alternative splice isoforms for CARD10 Gene


neXtProt entry for CARD10 Gene

Post-translational modifications for CARD10 Gene

  • Ubiquitination at Lys 778
  • Modification sites at PhosphoSitePlus

Other Protein References for CARD10 Gene

No data available for DME Specific Peptides for CARD10 Gene

Domains & Families for CARD10 Gene

Protein Domains for CARD10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CARD domain.
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with CARD10: view

Function for CARD10 Gene

Molecular function for CARD10 Gene

UniProtKB/Swiss-Prot Function:
Activates NF-kappa-B via BCL10 and IKK.

Gene Ontology (GO) - Molecular Function for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11259443
GO:0030159 receptor signaling complex scaffold activity NAS 11259443
genes like me logo Genes that share ontologies with CARD10: view

Phenotypes for CARD10 Gene

genes like me logo Genes that share phenotypes with CARD10: view

Animal Models for CARD10 Gene

MGI Knock Outs for CARD10:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARD10 Gene

Localization for CARD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD10 Gene


Subcellular locations from

Jensen Localization Image for CARD10 Gene COMPARTMENTS Subcellular localization image for CARD10 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11259443
GO:0032449 CBM complex NAS 15125833
genes like me logo Genes that share ontologies with CARD10: view

Pathways & Interactions for CARD10 Gene

genes like me logo Genes that share pathways with CARD10: view

Pathways by source for CARD10 Gene

Gene Ontology (GO) - Biological Process for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 11259443
GO:0007250 activation of NF-kappaB-inducing kinase activity ISS 11259443
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CARD10: view

No data available for SIGNOR curated interactions for CARD10 Gene

Transcripts for CARD10 Gene

Unigene Clusters for CARD10 Gene

Caspase recruitment domain family, member 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD10 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^
SP1: - -
SP3: -
SP4: - - - -
SP7: - - -
SP9: -
SP11: -

ExUns: 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1: -
SP2: -
SP8: -

Relevant External Links for CARD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARD10 Gene

mRNA expression in normal human tissues for CARD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CARD10 Gene

This gene is overexpressed in Plasma (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CARD10 Gene

Protein tissue co-expression partners for CARD10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CARD10 Gene:


SOURCE GeneReport for Unigene cluster for CARD10 Gene:


mRNA Expression by UniProt/SwissProt for CARD10 Gene:

Tissue specificity: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.
genes like me logo Genes that share expression patterns with CARD10: view

Primer Products

No data available for mRNA differential expression in normal tissues for CARD10 Gene

Orthologs for CARD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CARD10 34 35
  • 99.19 (n)
(Bos Taurus)
Mammalia CARD10 34 35
  • 90.08 (n)
(Canis familiaris)
Mammalia CARD10 34 35
  • 90.04 (n)
(Mus musculus)
Mammalia Card10 34 16 35
  • 86.71 (n)
(Rattus norvegicus)
Mammalia Card10 34
  • 85.78 (n)
(Ornithorhynchus anatinus)
Mammalia CARD10 35
  • 74 (a)
(Monodelphis domestica)
Mammalia CARD10 35
  • 69 (a)
(Gallus gallus)
Aves CARD10 34 35
  • 71.14 (n)
(Anolis carolinensis)
Reptilia CARD10 35
  • 56 (a)
(Danio rerio)
Actinopterygii CARD10 35
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 21 (a)
Species where no ortholog for CARD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD10 Gene

Gene Tree for CARD10 (if available)
Gene Tree for CARD10 (if available)

Paralogs for CARD10 Gene

Paralogs for CARD10 Gene

(1) SIMAP similar genes for CARD10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CARD10: view

Variants for CARD10 Gene

Sequence variations from dbSNP and Humsavar for CARD10 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111269974 -- 37,501,346(+) CTGCT(G/T)CAGCC intron-variant
rs111291519 -- 37,510,038(+) CCTGC(C/T)GCAGG intron-variant
rs111415655 -- 37,502,685(+) GAGGA(C/T)GAAGA reference, synonymous-codon
rs111458784 -- 37,502,961(+) CAGCC(G/T)GGAAC intron-variant
rs111466036 -- 37,507,455(+) AAGGG(C/T)CATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CARD10 Gene

Variant ID Type Subtype PubMed ID
esv1010487 CNV deletion 20482838
esv1582981 CNV deletion 17803354
esv2496764 CNV insertion 19546169
esv2724214 CNV deletion 23290073
esv2724215 CNV deletion 23290073
esv2724216 CNV deletion 23290073
esv3438 CNV loss 18987735
esv3558147 CNV deletion 23714750
esv5893 CNV loss 19470904
nsv1057617 CNV gain 25217958
nsv1151872 CNV deletion 26484159
nsv512657 CNV loss 21212237
nsv829203 CNV loss 20364138

Variation tolerance for CARD10 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.40; 88.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CARD10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD10 Gene

Disorders for CARD10 Gene

Relevant External Links for CARD10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CARD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD10 Gene

Publications for CARD10 Gene

  1. CARD10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with Bcl10 and activates NF-kappa B. (PMID: 11259443) Wang L. … Bertin J. (J. Biol. Chem. 2001) 2 3 4 64
  2. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. (PMID: 11356195) Gaide O. … Tschopp J. (FEBS Lett. 2001) 2 3 4 64
  3. Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. (PMID: 21307088) Khor C.C. … Aung T. (Hum. Mol. Genet. 2011) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64

Products for CARD10 Gene

Sources for CARD10 Gene

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