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CARD10 Gene

protein-coding   GIFtS: 60
GCID: GC22M037886

Caspase Recruitment Domain Family, Member 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caspase Recruitment Domain Family, Member 101 2     BIMP12 5
CARMA32 3 5     Bcl10 Binding Protein And Activator Of NFKB2
Carma 32 3     CARD-Containing MAGUK 3 Protein2
CARD-Containing MAGUK Protein 32 3     Caspase Recruitment Domain-Containing Protein 102

External Ids:    HGNC: 164221   Entrez Gene: 297752   Ensembl: ENSG000001000657   OMIM: 6072095   UniProtKB: Q9BWT73   

Export aliases for CARD10 gene to outside databases

Previous GC identifers: GC22M034500 GC22M036129 GC22M036210 GC22M020852


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CARD10 Gene:
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It
participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several
other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates
NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 (PubMed 11259443)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for CARD10 Gene:
CARD10 (caspase recruitment domain family, member 10) is a protein-coding gene. GO annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is CARD14.

UniProtKB/Swiss-Prot: CAR10_HUMAN, Q9BWT7
Function: Activates NF-kappa-B via BCL10 and IKK

Gene Wiki entry for CARD10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CARD10 gene promoter:
         GR   GR-beta   Olf-1   NF-E2 p45   c-Ets-1   HEN1   Pax-3   GR-alpha   ZID   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CARD10 promoter sequence
   Search Chromatin IP Primers for CARD10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CARD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

CARD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CARD10 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037886:  view genomic region     (about GC identifiers)

Start:
37,886,400 bp from pter      End:
37,915,549 bp from pter
Size:
29,150 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CAR10_HUMAN, Q9BWT7 (See protein sequence)
Recommended Name: Caspase recruitment domain-containing protein 10  
Size: 1032 amino acids; 115931 Da
Subunit: CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with
MALT1, where MALT1 binds to BCL10 (By similarity)
Caution: Supposed to contain a SH3, a PDZ and a guanylate kinase-like domain. But none of these 3 domains are
detected by PROSITE, Pfam or SMART
Secondary accessions: Q14CQ8 Q5TFG6 Q9UGR5 Q9UGR6 Q9Y3H0

Explore the universe of human proteins at neXtProt for CARD10: NX_Q9BWT7

Explore proteomics data for CARD10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys778
  • Modification sites at PhosphoSitePlus

  • See CARD10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055365.2  
    ENSEMBL proteins: 
     ENSP00000384570   ENSP00000385799   ENSP00000251973   ENSP00000416239   ENSP00000393411  

    CARD10 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CARD10
    OriGene MassSpec for CARD10
    OriGene Custom Protein Services for CARD10
    GenScript Custom Purified and Recombinant Proteins Services for CARD10
    Novus Biologicals CARD10 Proteins
    Novus Biologicals CARD10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CARD10

     
    Search eBioscience for Proteins for CARD10 

     
    antibodies-online proteins for CARD10 (2 products) 

     
    antibodies-online peptides for CARD10

    CARD10 Antibody Products:

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    Abcam antibodies for CARD10
    Cloud-Clone Corp. Antibodies for CARD10
    ThermoFisher Antibodies for CARD10
    antibodies-online antibodies for CARD10 (50 products) 

    CARD10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CARD10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CARD10
    Cloud-Clone Corp. CLIAs for CARD10
    Search eBioscience for ELISAs for CARD10 
    antibodies-online kits for CARD10 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q9BWT7

    ProtoNet protein and cluster: Q9BWT7

    1 Blocks protein domain: IPB001315 CARD interaction domain

    UniProtKB/Swiss-Prot: CAR10_HUMAN, Q9BWT7
    Similarity: Contains 1 CARD domain


    Find genes that share domains with CARD10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAR10_HUMAN, Q9BWT7
    Function: Activates NF-kappa-B via BCL10 and IKK

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11259443
    GO:0030159receptor signaling complex scaffold activity NAS11259443
         
    Find genes that share ontologies with CARD10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CARD10:
     Elongated cells 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Card10):
     mortality/aging  nervous system 

    Find genes that share phenotypes with CARD10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Card10tm1Xlin for CARD10

       genOway: Develop your customized and physiologically relevant rodent model for CARD10

    miRNA
    Products:
        
    miRTarBase miRNAs that target CARD10:
    hsa-mir-24-3p (MIRT030440), hsa-mir-16-5p (MIRT031650), hsa-mir-103a-3p (MIRT027101)

    Block miRNA regulation of human, mouse, rat CARD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CARD10 (see all 14):
    hsa-miR-146a hsa-miR-15a hsa-miR-2278 hsa-miR-1301 hsa-miR-497 hsa-miR-424 hsa-miR-19b hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidCARD10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CARD10
    Predesigned siRNA for gene silencing in human, mouse, rat CARD10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CARD10

    Clone
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    OriGene clones in human, mouse for CARD10 (see all 6)
    OriGene ORF clones in mouse, rat for CARD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CARD10 (NM_014550)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD10

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CARD10
    Browse ESI BIO Cell Lines and PureStem Progenitors for CARD10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAR10_HUMAN, Q9BWT7: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm NAS11259443
    GO:0032449CBM complex NAS15125833

    Find genes that share ontologies with CARD10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CARD10 About    
    See pathways by source

    SuperPathContained pathways About
    1NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72
    2TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    3GPCR Pathway
    GPCR Pathway0.62
    4ErbB4 Pathway
    PI3K Signaling in B-Lymphocyte0.35

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CARD10
        GPCR Pathway
    PI3K Signaling in B-Lymphocyte
    PKC-Theta Pathway
    NF-KappaB Family Pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CARD10: 
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CARD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for CARD10 (Q9BWT72, 3 ENSP000002519734) via UniProtKB, MINT, STRING, and/or I2D (see all 574)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=3 STRING: ENSP00000358622
    MALT1Q9UDY83, ENSP000003192794I2D: score=1 STRING: ENSP00000319279
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    BCL10O959993I2D: score=6 
    ATXN7O152653I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly NAS11259443
    GO:0007250activation of NF-kappaB-inducing kinase activity IDA11259443
    GO:0042981regulation of apoptotic process IEA--

    Find genes that share ontologies with CARD10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CARD10 (CAR10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CARD10 gene: 
    NM_014550.3  

    Unigene Cluster for CARD10:

    Caspase recruitment domain family, member 10
    Hs.57973  [show with all ESTs]
    Unigene Representative Sequence: AY028896
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488141(uc003asu.1 uc011ank.1) ENST00000403299(uc003ast.1 uc003asx.1)
    ENST00000467812(uc003asv.1) ENST00000406271(uc003asw.1) ENST00000251973(uc003asy.1)
    ENST00000437756 ENST00000486118 ENST00000433485 ENST00000476871 ENST00000494166

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CARD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CARD10 (see all 14):
    hsa-miR-146a hsa-miR-15a hsa-miR-2278 hsa-miR-1301 hsa-miR-497 hsa-miR-424 hsa-miR-19b hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidCARD10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CARD10
    Predesigned siRNA for gene silencing in human, mouse, rat CARD10
    Clone
    Products:
         
    OriGene clones in human, mouse for CARD10 (see all 6)
    OriGene ORF clones in mouse, rat for CARD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CARD10 (NM_014550)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CARD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CARD10
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CARD10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CARD10
      QuantiTect SYBR Green Assays in human, mouse, rat CARD10
      QuantiFast Probe-based Assays in human, mouse, rat CARD10

    Additional mRNA sequence: 

    AF086324.1 AK074906.1 AK296176.1 AY028896.1 AY032928.1 BC032058.1 BC113659.1 BC117403.1 

    10 DOTS entries:

    DT.309950  DT.95272280  DT.101961630  DT.100028856  DT.100028855  DT.120648630  DT.120648667  DT.91814521 
    DT.99971659  DT.95272279 

    Selected AceView cDNA sequences (see all 113):

    BQ690010 AI948914 AI829451 AW024347 BI764337 AI762204 AW137435 BE906442 
    CB156193 CB046689 AI739413 BM311316 AF086324 BE221808 AW969602 AY028896 
    AW612524 CD625764 BE048709 BU687323 BM980824 NM_014550 AA513369 BQ688908 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CARD10 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^
    SP1:                                                                                                                    -     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                  -                                                                                                         
    SP4:                                                                                            -     -                 -     -                                 
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b
    SP1:        -                                                   
    SP2:        -                                                   
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for CARD10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CARD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATGTACG
    CARD10 Expression
    About this image


    CARD10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)
             Metanephros
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    CARD10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CARD10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.57973

    UniProtKB/Swiss-Prot: CAR10_HUMAN, Q9BWT7
    Tissue specificity: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and
    lung. Also found in fetal lung, liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CARD10: 
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CARD10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CARD10
    QuantiTect SYBR Green Assays in human, mouse, rat CARD10
    QuantiFast Probe-based Assays in human, mouse, rat CARD10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CARD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CARD10 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Card101 , 5 caspase recruitment domain family, member 101, 5 86.71(n)1
    91.77(a)1
      15 (37.70 cM)5
    1058441  NM_130859.21  NP_570929.21 
     787751385 
    chicken
    (Gallus gallus)
    Aves CARD101 caspase recruitment domain family, member 10 71.14(n)
    70.11(a)
      418041  XM_416277.4  XP_416277.4 
    lizard
    (Anolis carolinensis)
    Reptilia CARD106
    caspase recruitment domain family, member 10
    56(a)
    1 ↔ 1
    5(23490064-23551465)
    zebrafish
    (Danio rerio)
    Actinopterygii CARD106
    caspase recruitment domain family, member 10
    46(a)
    1 ↔ 1
    3(3202776-3225050) ENSDARG00000088099


    ENSEMBL Gene Tree for CARD10 (if available)
    TreeFam Gene Tree for CARD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CARD10 gene
    CARD142  CARD112  CARD92  
    1 SIMAP similar gene for CARD10 using alignment to 5 protein entries:     CAR10_HUMAN (see all proteins):
    CARD9

    Find genes that share paralogs with CARD10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CARD10 (see all 889)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904601981,2
    --37885960(+) TGGCAC/TTTCTT 1 -- ds50010--------
    rs1912849331,2
    --37885989(+) TTGCTA/CCCAGT 1 -- ds50010--------
    rs1493680461,2
    --37886035(+) AGGAAA/CCTGCG 1 -- ds50010--------
    rs622350231,2
    C--37886050(+) TACCAA/GGGGTT 1 -- ds50010--------
    rs31805861,2
    C--37886401(-) TCATAG/AATGCT 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs1835204741,2
    C--37886457(+) GGCCCA/GTTAAT 1 -- ut310--------
    rs1398230021,2
    --37886469(+) ATCCAC/TGGGCC 1 -- ut310--------
    rs1441079161,2
    C--37886475(+) GGGCCA/GTACAT 1 -- ut310--------
    rs561749811,2
    C,F--37886499(-) GAGGGC/TGGCTG 1 -- ut311Minor allele frequency- T:0.06WA 118
    rs1880978981,2
    --37886514(+) GCCCCC/GCAAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CARD10 (37886400 - 37915549 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CARD10 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724215CNV Deletion23290073
    esv1010487CNV Deletion20482838
    esv1582981CNV Deletion17803354
    esv2724216CNV Deletion23290073
    esv3438CNV Deletion18987735
    esv2724214CNV Deletion23290073
    esv2496764CNV Insertion19546169
    nsv829203CNV Loss20364138
    nsv915028CNV Loss21882294
    esv5893CNV Loss19470904

    Human Gene Mutation Database (HGMD): CARD10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CARD10
    DNA2.0 Custom Variant and Variant Library Synthesis for CARD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607209    OMIM disorders: --


    Find genes that share disorders with CARD10           About GenesLikeMe

    Genetic Association Database (GAD): CARD10
    Human Genome Epidemiology (HuGE) Navigator: CARD10 (8 documents)

    Export disorders for CARD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CARD10 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with CARD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CARD10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with Bcl10 and activates NF-kappa B. (PubMed id 11259443)1, 2, 3 Wang L.... Bertin J. (J. Biol. Chem. 2001)
    2. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. (PubMed id 11356195)1, 2, 3 Gaide O.... Tschopp J. (FEBS Lett. 2001)
    3. Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. (PubMed id 21307088)1, 4 Khor C.C....Aung T. (Hum. Mol. Genet. 2011)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    9. CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. (PubMed id 18757306)1, 9 Medoff B.D....Xavier R.J. (Am. J. Respir. Cell Mol. Biol. 2009)
    10. A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-kappaB. (PubMed id 18349075)1, 9 Stilo R....Vito P. (J. Cell. Sci. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29775 HGNC: 16422 AceView: CARD10 Ensembl:ENSG00000100065 euGenes: HUgn29775
    ECgene: CARD10 H-InvDB: CARD10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CARD10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CARD10 gene:
    Search GeneIP for patents involving CARD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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