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Aliases for CAPZB Gene

Aliases for CAPZB Gene

  • Capping Protein (Actin Filament) Muscle Z-Line, Beta 2 3
  • CapZ Beta 3 4
  • CAPPB 3 6
  • F-Actin-Capping Protein Subunit Beta 3
  • CAPZ 3
  • CAPB 3

External Ids for CAPZB Gene

Previous GeneCards Identifiers for CAPZB Gene

  • GC01M019225
  • GC01M018690
  • GC01M018811
  • GC01M019135
  • GC01M019134
  • GC01M019410
  • GC01M019537
  • GC01M019665
  • GC01M017911

Summaries for CAPZB Gene

Entrez Gene Summary for CAPZB Gene

  • This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

GeneCards Summary for CAPZB Gene

CAPZB (Capping Protein (Actin Filament) Muscle Z-Line, Beta) is a Protein Coding gene. Among its related pathways are Hemostasis and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include actin binding and beta-tubulin binding.

UniProtKB/Swiss-Prot for CAPZB Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Wiki entry for CAPZB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPZB Gene

Genomics for CAPZB Gene

Regulatory Elements for CAPZB Gene

Genomic Location for CAPZB Gene

Start:
19,338,773 bp from pter
End:
19,485,641 bp from pter
Size:
146,869 bases
Orientation:
Minus strand

Genomic View for CAPZB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPZB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZB Gene

Proteins for CAPZB Gene

  • Protein details for CAPZB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47756-CAPZB_HUMAN
    Recommended name:
    F-actin-capping protein subunit beta
    Protein Accession:
    P47756
    Secondary Accessions:
    • Q32Q68
    • Q5U0L4
    • Q8TB49
    • Q9NUC4

    Protein attributes for CAPZB Gene

    Size:
    277 amino acids
    Molecular mass:
    31350 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with ARHGAP17 and RCSD1/CAPZIP. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53.

    Alternative splice isoforms for CAPZB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPZB Gene

Proteomics data for CAPZB Gene at MOPED

Post-translational modifications for CAPZB Gene

  • Ubiquitination at Lys57, Lys78, Lys95, Lys223, Lys235, and Lys254
  • Modification sites at PhosphoSitePlus

Other Protein References for CAPZB Gene

Antibody Products

No data available for DME Specific Peptides for CAPZB Gene

Domains for CAPZB Gene

Protein Domains for CAPZB Gene

Graphical View of Domain Structure for InterPro Entry

P47756

UniProtKB/Swiss-Prot:

CAPZB_HUMAN :
  • P47756
Family:
  • Belongs to the F-actin-capping protein beta subunit family.
genes like me logo Genes that share domains with CAPZB: view

No data available for Gene Families for CAPZB Gene

Function for CAPZB Gene

Molecular function for CAPZB Gene

GENATLAS Biochemistry:
actin-capping protein Z,beta subunit 1
UniProtKB/Swiss-Prot Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for CAPZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS 7665558
GO:0005515 protein binding --
GO:0048487 beta-tubulin binding --
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CAPZB: view

Phenotypes for CAPZB Gene

genes like me logo Genes that share phenotypes with CAPZB: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAPZB Gene

Localization for CAPZB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPZB Gene

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPZB Gene COMPARTMENTS Subcellular localization image for CAPZB gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CAPZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton TAS 16130169
GO:0005884 actin filament IBA --
GO:0008290 F-actin capping protein complex IEA --
genes like me logo Genes that share ontologies with CAPZB: view

Pathways for CAPZB Gene

genes like me logo Genes that share pathways with CAPZB: view

Pathways by source for CAPZB Gene

Gene Ontology (GO) - Biological Process for CAPZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007596 blood coagulation TAS --
GO:0010591 regulation of lamellipodium assembly IBA --
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with CAPZB: view

Transcripts for CAPZB Gene

Unigene Clusters for CAPZB Gene

Capping protein (actin filament) muscle Z-line, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPZB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4:
SP5: - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: -
SP11: - -

ExUns: 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CAPZB Gene

GeneLoc Exon Structure for
CAPZB
ECgene alternative splicing isoforms for
CAPZB

Expression for CAPZB Gene

mRNA expression in normal human tissues for CAPZB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPZB Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPZB Gene

SOURCE GeneReport for Unigene cluster for CAPZB Gene Hs.432760

genes like me logo Genes that share expressions with CAPZB: view

Expression partners for CAPZB Gene

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAPZB Gene

Orthologs for CAPZB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAPZB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAPZB 35
  • 92.36 (n)
  • 98.34 (a)
CAPZB 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPZB 35
  • 93.91 (n)
  • 99 (a)
CAPZB 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capzb 35
  • 92.14 (n)
  • 98.67 (a)
Capzb 16
Capzb 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAPZB 35
  • 99.38 (n)
  • 100 (a)
CAPZB 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capzb 35
  • 92.87 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPZB 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPZB 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPZB 35
  • 88.02 (n)
  • 99.26 (a)
CAPZB 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPZB 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6774 35
African clawed frog
(Xenopus laevis)
Amphibia capzb-prov 35
zebrafish
(Danio rerio)
Actinopterygii capzb 35
  • 79.38 (n)
  • 94.07 (a)
wufk65f06 35
capzb 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11173 35
fruit fly
(Drosophila melanogaster)
Insecta cpb 37
  • 81 (a)
cpb 35
  • 70.9 (n)
  • 81.72 (a)
cpb 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007864 35
  • 72.61 (n)
  • 82.53 (a)
worm
(Caenorhabditis elegans)
Secernentea cap-2 37
  • 66 (a)
cap-2 35
  • 62.52 (n)
  • 67.17 (a)
cap-2 36
  • 66 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL101C 35
  • 54.05 (n)
  • 48.61 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04225g 35
  • 50.32 (n)
  • 47.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP2 35
  • 51.84 (n)
  • 50.95 (a)
CAP2 36
  • 45 (a)
OneToOne
CAP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G71790 35
  • 56.84 (n)
  • 54.7 (a)
rice
(Oryza sativa)
Liliopsida Os.15764 35
Os03g0381200 35
  • 58.33 (n)
  • 54.24 (a)
corn
(Zea mays)
Liliopsida Zm.12180 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07471 35
  • 58.49 (n)
  • 56.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes acp2 35
  • 53.17 (n)
  • 54.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6107 36
  • 73 (a)
OneToOne
Species with no ortholog for CAPZB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPZB Gene

ENSEMBL:
Gene Tree for CAPZB (if available)
TreeFam:
Gene Tree for CAPZB (if available)

Paralogs for CAPZB Gene

No data available for Paralogs for CAPZB Gene

Variants for CAPZB Gene

Sequence variations from dbSNP and Humsavar for CAPZB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6889 -- 19,339,003(-) GACTC(G/T)CCCGT utr-variant-3-prime
rs7667 -- 19,392,330(-) CCCTG(C/T)AGTCT intron-variant
rs8329 -- 19,339,353(+) GAGCC(A/C/G)GAGGA utr-variant-3-prime
rs10388 -- 19,392,262(+) GCAAG(C/T)CAGCA intron-variant
rs13803 -- 19,338,852(+) ATGTA(C/G)ATTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CAPZB Gene

Variant ID Type Subtype PubMed ID
nsv871933 CNV Loss 21882294
nsv871934 CNV Loss 21882294
dgv186n71 CNV Loss 21882294
nsv871443 CNV Loss 21882294
esv2744841 CNV Deletion 23290073
nsv834358 CNV Loss 17160897
nsv5409 CNV Insertion 18451855
esv2744852 CNV Deletion 23290073
esv2398290 CNV Deletion 18987734
esv3747 CNV Deletion 18987735
esv2744863 CNV Deletion 23290073
nsv471771 CNV Loss 16327809
esv6224 CNV Loss 19470904
dgv26e199 CNV Deletion 23128226
esv2744874 CNV Deletion 23290073
esv2744885 CNV Deletion 23290073

Relevant External Links for CAPZB Gene

HapMap Linkage Disequilibrium report
CAPZB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPZB Gene

Disorders for CAPZB Gene

Relevant External Links for CAPZB

Genetic Association Database (GAD)
CAPZB
Human Genome Epidemiology (HuGE) Navigator
CAPZB

No disorders were found for CAPZB Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CAPZB Gene

Publications for CAPZB Gene

  1. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PMID: 7665558) Barron-Casella E.A. … Casella J.F. (J. Biol. Chem. 1995) 3 4 23
  2. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PMID: 16678097) Wells C.D. … Pawson T. (Cell 2006) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PMID: 19922875) Derivery E. … Gautreau A. (Dev. Cell 2009) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CAPZB Gene

Sources for CAPZB Gene

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