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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPZB Gene

protein-coding   GIFtS: 63
GCID: GC01M019665

capping protein (actin filament) muscle Z-line, beta

 Explore 10 diseases affiliated with
CAPZB via our new
 Human Malady Compendium 
Biological research products
for CAPZB
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Capping Protein (Actin Filament) Muscle Z-Line, Beta1 2
CapZ Beta2 3
CAPPB2 5
CAPB2
CAPZ2
F-Actin-Capping Protein Subunit Beta2

External Ids:    HGNC: 14911   Entrez Gene: 8322   Ensembl: ENSG000000775497   OMIM: 6015725   UniProtKB: P477563   
ORGUL members:         
NONCODE:n410721    

Export aliases for CAPZB gene to outside databases

Previous GC identifers: GC01M019225 GC01M018690 GC01M018811 GC01M019135 GC01M019134 GC01M019410 GC01M019537 GC01M017911


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAPZB:
This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping
protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and
disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as
in stabilizing actin filament lengths in muscle and nonmuscle cells. Multiple alternatively spliced transcript
variants encoding different isoforms have been found.(provided by RefSeq, Apr 2011)

UniProtKB/Swiss-Prot: CAPZB_HUMAN, P47756
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
(barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin
and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and
cytoskeletal organization

Gene Wiki entry for CAPZB


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPZB gene promoter:
         AML1a   MEF-2   Ik-3   MZF-1   MEF-2A   FAC1   Ik-2   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPZB promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPZB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPZB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.1

CAPZB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPZB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M019665:  view genomic region     (about GC identifiers)

Start:
19,665,267 bp from pter      End:
19,812,066 bp from pter
Size:
146,800 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAPZB_HUMAN, P47756 (See protein sequence)
Recommended Name: F-actin-capping protein subunit beta  
Size: 277 amino acids; 31350 Da
Subunit: Heterodimer of an alpha and a beta subunit. Interacts with ARHGAP17 and RCSD1/CAPZIP. Component of the WASH
complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit
beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033,
KIAA0196 and CCDC53
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: Q32Q68 Q5U0L4 Q8TB49 Q9NUC4
Alternative splicing: 3 isoforms:  P47756-1   P47756-2   P47756-3   

Explore the universe of human proteins at neXtProt for CAPZB: NX_P47756

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P47756

  • CAPZB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193469.1  NP_004921.1  

    ENSEMBL proteins: 
     ENSP00000264203   ENSP00000364286   ENSP00000364284   ENSP00000401010   ENSP00000392781  
     ENSP00000400757   ENSP00000383862   ENSP00000264202  
    Reactome Protein details: P47756
    Human Recombinant Protein Products: 
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    Novus Biologicals CAPZB Lysates
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    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169
    GO:0008290F-actin capping protein complex IEA--
    GO:0015629actin cytoskeleton TAS7665558


    CAPZB for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CAPZB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR019771 F-actin_capping_bsu_CS
     IPR001698 WASH_F-actin_cap_beta

    Graphical View of Domain Structure for InterPro Entry P47756

    ProtoNet protein and cluster: P47756

    1 Blocks protein family: IPB001698 F-actin capping protein

    UniProtKB/Swiss-Prot: CAPZB_HUMAN, P47756
    Similarity: Belongs to the F-actin-capping protein beta subunit family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CAPZB_HUMAN, P47756
    Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
    (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin
    and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and
    cytoskeletal organization

         Genatlas biochemistry entry for CAPZB:
    actin-capping protein Z,beta subunit 1

    miRNA
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    hsa-miR-140-3p hsa-miR-362-3p hsa-miR-4263 hsa-miR-4282 hsa-miR-1297 hsa-miR-329 hsa-miR-587 hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidCAPZB 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----


    CAPZB for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CAPZB:
     Low eccentricity cells  Synthetic lethal with Ras 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Capzb):
     behavior/neurological  homeostasis/metabolism  mortality/aging 

    CAPZB for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments1.00
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling_Neurofilaments0.91
    2Cell cycle_Spindle assembly and chromosome separation
    Cell cycle_Spindle assembly and chromosome separation1.00
    Cell cycle Spindle assembly and chromosome separation0.94
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production1.00
    4Platelet activation, signaling and aggregation
    Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for CAPZB
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for CAPZB
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments

    2        Reactome Pathways for CAPZB
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    CAPZB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAPZB

    5/105 Interacting proteins for CAPZB (P477562, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48438 I2D: score=2 
    RIPK3Q9Y5722, 3MINT-49151 I2D: score=2 
    RPP14O950592, 3MINT-8269131 I2D: score=2 
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS16130169
    GO:0007010cytoskeleton organization IMP--
    GO:0007596blood coagulation TAS--
    GO:0022604regulation of cell morphogenesis IMP--
    GO:0030030cell projection organization ----


    CAPZB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAPZB
    Search CenterWatch for drugs/clinical trials and news about CAPZB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAPZB gene (3 alternative transcripts): 
    NM_001206540.1  NM_004930.3  NM_001206541.1  

    Unigene Cluster for CAPZB:

    Capping protein (actin filament) muscle Z-line, beta
    Hs.432760  [show with all ESTs]
    Unigene Representative Sequence: NR_038125
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264203(uc009vpk.3) ENST00000375144 ENST00000375142 ENST00000433834
    ENST00000413711 ENST00000459967 ENST00000457768 ENST00000489607 ENST00000482808
    ENST00000401084(uc010ocz.2 uc001bce.3 uc021ohr.1) ENST00000264202


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    hsa-miR-140-3p hsa-miR-362-3p hsa-miR-4263 hsa-miR-4282 hsa-miR-1297 hsa-miR-329 hsa-miR-587 hsa-miR-377
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPZB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPZB

    Additional cDNA sequence: 

    AK125085.1 AK301442.1 AK313113.1 BC008095.1 BC012305.1 BC024601.1 BC107752.1 BC109241.1 
    BC109242.1 BT019470.1 BT019471.1 NR_038125.1 U03271.1 

    24/38 DOTS entries (see all 38):

    DT.97863846  DT.92461301  DT.85104988  DT.95279935  DT.100881833  DT.100881810  DT.100881814  DT.100881835 
    DT.85101948  DT.95115140  DT.95137668  DT.121420932  DT.40200863  DT.100881832  DT.40116293  DT.95220605 
    DT.97760109  DT.100881812  DT.100881825  DT.121421089  DT.40116290  DT.95187152  DT.95220509  DT.100881816 

    24/819 AceView cDNA sequences (see all 819):

    BF876422 CB153755 BX423008 BQ649251 AA430524 AW193131 BU623792 AI567992 
    AA909820 BU151117 BF970705 BQ959244 BI856646 CR622250 CR595642 BI916209 
    BC008095 CR615786 BQ057928 CD364764 CR615877 CR609341 BU179541 CD557935 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CAPZB (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                    -     -     -           -           -     -     -     -     -                       -                                         -     -   
    SP2:                    -     -     -     -     -           -     -     -     -     -                       -                                               -   
    SP3:                    -     -     -     -     -           -     -     -     -     -                       -     -     -     -     -                       -   
    SP4:                                                                                                                                                            
    SP5:                                                        -     -     -     -     -                       -                                                   

    ExUns: 19a · 19b · 19c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CAPZB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPZB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAACCAGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CAPZB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPZB

    SOURCE GeneReport for Unigene cluster: Hs.432760
        SABiosciences Custom PCR Arrays for CAPZB
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPZB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAPZB gene from 10/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capzb1 , 5 capping protein (actin filament) muscle Z-line, beta1, 5 92.77(n)1
    100(a)1
      4 (70.59 cM)5
    123451  NM_009798.31  NP_033928.11 
     1391928995 
    chicken
    (Gallus gallus)
    Aves CAPZB1 capping protein (actin filament) muscle Z-line, beta 88.07(n)
    99.26(a)
      396418  NM_001173529.1  NP_001167000.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAPZB6
    --
    97(a)
    1 ↔ 1
    GL343959.1(15482-15577)
    African clawed frog
    (Xenopus laevis)
    Amphibia capzb-prov2 capping protein beta 1 83.86(n)    BC041233.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk65f062 wufk65f06 78.97(n)   335083  BC055514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cpb1 , 3 F-actin capping3
    capping protein beta1
    81(a)3
    71(n)1
    81.78(a)1
      2 22B13
    333461  NM_057657.41  NP_477005.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cap-21 , 3 F-actin capping protein beta subunit3
    Protein CAP-21
    66(a)3
    62.55(n)1
    67.04(a)1
      II(10869140-10870324)3
    1746731  NM_063935.51  NP_496336.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAP2(YIL034C)4
    CAP21
    Beta subunit of the capping protein (CP) heterodimer more4
    Cap2p1
    52.02(n)1
    51.14(a)1
      9(290089-289226)4
    8547771, 4  NP_012230.31  NP_012230.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G717901 capping protein (actin filament) muscle Z-line, beta 56.84(n)
    54.7(a)
      843509  NM_105837.3  NP_177324.2 
    rice
    (Oryza sativa)
    Liliopsida Os.157642 Oryza sativa (japonica cultivar-group) cDNA clone0 more 75.41(n)    AK061302.1 


    ENSEMBL Gene Tree for CAPZB (if available)
    TreeFam Gene Tree for CAPZB (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3034 NCBI SNPs in CAPZB are shown (see all 3034    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs66783761,2
    C,F,A,H,--17911104(+) aGATGT/CTGCAT 3 -- int1 ds500110Minor allele frequency- C:0.01NS EA NA 1344
    rs1151870841,2
    C,--17911458(+) AGGGCG/AGCGGG 3 -- ds5001 int11Minor allele frequency- A:0.01WA 118
    rs2143241,2
    C,H--17911760(+) TGGCCG/AGAAGA 3 -- nc-transcript-variantut31 ese36Minor allele frequency- A:0.00NS EA NA 422
    rs1137007701,2
    C--17911783(+) GCGGCC/ACCCCC 3 -- nc-transcript-variantut311Minor allele frequency- A:0.00CSA 1
    rs140871,2
    C,F,H,--17911877(+) CCCCTG/ATCCCC 3 -- ut31 nc-transcript-variantese32Minor allele frequency- A:0.03MN NS 410
    rs1120203231,2
    C--17911882(+) GTCCCC/G/TACGAC 6 -- ut31 nc-transcript-variant1CSA 1
    rs83291,2
    C,F,--17912173(+) GAGCCA/C/GGAGGA 6 -- ut31 nc-transcript-variant4MN NA CSA 307
    rs795591401,2
    F,--17912607(+) GCAAAG/AGGGTA 3 -- int11Minor allele frequency- A:0.04WA 118
    rs121282261,2
    C,F,H,--17912654(+) CCCTGT/GGGGGG 3 -- int16Minor allele frequency- G:0.02NS EA NA 506
    rs762081291,2
    --17912693(+) CATCTC/TTGCCC 3 -- int10--------

    HapMap Linkage Disequilibrium report for CAPZB (19665267 - 19812066 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for CAPZB
         4 Indels: 10859 41589 60804 44486

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAPZB
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPZB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CAPZB for disorders           About GeneDecksing

    OMIM gene information: 601572    OMIM disorders: --

    10 diseases for CAPZB:    About MalaCards
    posterior uveitis    chronic lymphocytic leukemia    lymphocytic leukemia    goiter
    uveitis    choroiditis    leukemia    retinitis
    thyroiditis    malaria

    Human Genome Epidemiology (HuGE) Navigator: CAPZB (2 documents)

    Export disorders for CAPZB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPZB gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with CAPZB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PubMed id 7665558)1, 2, 9 Barron-Casella E.A.... Casella J.F. (1995)
    2. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PubMed id 19922875)1, 2 Derivery E.... Gautreau A. (2009)
    3. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PubMed id 16678097)1, 2 Wells C.D.... Pawson T. (2006)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
    10. Meta-analysis of two genome-wide association studies i dentifies four genetic loci associated with thyroid function. (PubMed id 22494929)1 Rawal R....Homuth G. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 832 HGNC: 1491 AceView: CAPZB Ensembl:ENSG00000077549 euGenes: HUgn832
    ECgene: CAPZB H-InvDB: CAPZB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPZB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAPZB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAPZB gene:
    Search GeneIP for patents involving CAPZB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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     Regulatory tfbs in CAPZB promoter
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