Aliases for CAPZB Gene
External Ids for CAPZB Gene
Previous GeneCards Identifiers for CAPZB Gene
This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]
GeneCards Summary for CAPZB Gene
CAPZB (Capping Actin Protein Of Muscle Z-Line Beta Subunit) is a Protein Coding gene. Diseases associated with CAPZB include Epithelioid Sarcoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include actin binding and beta-tubulin binding.
UniProtKB/Swiss-Prot for CAPZB Gene
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.