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Aliases for CAPZA3 Gene

Aliases for CAPZA3 Gene

  • Capping Protein (Actin Filament) Muscle Z-Line, Alpha 3 2 3
  • Germ Cell-Specific Protein 3 3 4
  • CapZ Alpha-3 3 4
  • CP-Alpha-3 3 4
  • CAPPA3 3 6
  • Gsg3 3 4
  • F-Actin Capping Protein Alpha-3 Subunit 3
  • F-Actin-Capping Protein Subunit Alpha-3 3
  • CAPAA3 4

External Ids for CAPZA3 Gene

Summaries for CAPZA3 Gene

Entrez Gene Summary for CAPZA3 Gene

  • This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPZA3 Gene

CAPZA3 (Capping Protein (Actin Filament) Muscle Z-Line, Alpha 3) is a Protein Coding gene. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Cell cycle_Spindle assembly and chromosome separation. GO annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.

UniProtKB/Swiss-Prot for CAPZA3 Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPZA3 Gene

Genomics for CAPZA3 Gene

Genomic Location for CAPZA3 Gene

Start:
18,738,101 bp from pter
End:
18,739,188 bp from pter
Size:
1,088 bases
Orientation:
Plus strand

Genomic View for CAPZA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPZA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZA3 Gene

Regulatory Elements for CAPZA3 Gene

Proteins for CAPZA3 Gene

  • Protein details for CAPZA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KX2-CAZA3_HUMAN
    Recommended name:
    F-actin-capping protein subunit alpha-3
    Protein Accession:
    Q96KX2
    Secondary Accessions:
    • Q969J0

    Protein attributes for CAPZA3 Gene

    Size:
    299 amino acids
    Molecular mass:
    35025 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit (By similarity). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53.

neXtProt entry for CAPZA3 Gene

Proteomics data for CAPZA3 Gene at MOPED

Post-translational modifications for CAPZA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPZA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAPZA3 Gene

Domains for CAPZA3 Gene

Protein Domains for CAPZA3 Gene

Suggested Antigen Peptide Sequences for CAPZA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KX2

UniProtKB/Swiss-Prot:

CAZA3_HUMAN
Family:
  • Belongs to the F-actin-capping protein alpha subunit family.:
    • Q96KX2
genes like me logo Genes that share domains with CAPZA3: view

No data available for Gene Families for CAPZA3 Gene

Function for CAPZA3 Gene

Molecular function for CAPZA3 Gene

UniProtKB/Swiss-Prot Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).

Gene Ontology (GO) - Molecular Function for CAPZA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CAPZA3: view

Phenotypes for CAPZA3 Gene

MGI mutant phenotypes for CAPZA3:
inferred from 1 alleles
GenomeRNAi human phenotypes for CAPZA3:
genes like me logo Genes that share phenotypes with CAPZA3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CAPZA3 Gene

Localization for CAPZA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPZA3 Gene COMPARTMENTS Subcellular localization image for CAPZA3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CAPZA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IDA 21630459
GO:0008290 F-actin capping protein complex IEA --
GO:0016020 membrane IEA --
GO:0030863 cortical cytoskeleton IEA --
genes like me logo Genes that share ontologies with CAPZA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPZA3 Gene

Pathways for CAPZA3 Gene

genes like me logo Genes that share pathways with CAPZA3: view

Pathways by source for CAPZA3 Gene

Gene Ontology (GO) - Biological Process for CAPZA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
GO:0030036 actin cytoskeleton organization --
GO:0051016 barbed-end actin filament capping IEA --
GO:0051693 actin filament capping --
genes like me logo Genes that share ontologies with CAPZA3: view

Transcripts for CAPZA3 Gene

mRNA/cDNA for CAPZA3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAPZA3 Gene

Capping protein (actin filament) muscle Z-line, alpha 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA3 Gene

No ASD Table

Relevant External Links for CAPZA3 Gene

GeneLoc Exon Structure for
CAPZA3
ECgene alternative splicing isoforms for
CAPZA3

Expression for CAPZA3 Gene

mRNA expression in normal human tissues for CAPZA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPZA3 Gene

This gene is overexpressed in Testis (50.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAPZA3 Gene

SOURCE GeneReport for Unigene cluster for CAPZA3 Gene Hs.131288

mRNA Expression by UniProt/SwissProt for CAPZA3 Gene

Q96KX2-CAZA3_HUMAN
Tissue specificity: Expressed exclusively in testis and sperm. Highest expression is found in the neck region of ejaculated sperm with lower levels found in the tail and postacrosome region.
genes like me logo Genes that share expressions with CAPZA3: view

Orthologs for CAPZA3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAPZA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPZA3 35
  • 99.44 (n)
  • 99.67 (a)
CAPZA3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPZA3 35
  • 88.18 (n)
  • 90.97 (a)
CAPZA3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPZA3 35
  • 92.75 (n)
  • 91.64 (a)
CAPZA3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capza3 35
  • 84.73 (n)
  • 91.3 (a)
Capza3 16
Capza3 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPZA3 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capza3 35
  • 84.39 (n)
  • 90.3 (a)
chicken
(Gallus gallus)
Aves CAPZA3 35
  • 54.7 (n)
  • 39.93 (a)
CAPZA3 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPZA3 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii capza1a 36
  • 34 (a)
OneToMany
capza1b 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cpa 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cap-1 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8055 36
  • 29 (a)
OneToMany
Species with no ortholog for CAPZA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAPZA3 Gene

ENSEMBL:
Gene Tree for CAPZA3 (if available)
TreeFam:
Gene Tree for CAPZA3 (if available)

Paralogs for CAPZA3 Gene

Paralogs for CAPZA3 Gene

Selected SIMAP similar genes for CAPZA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CAPZA3: view

Variants for CAPZA3 Gene

Relevant External Links for CAPZA3 Gene

HapMap Linkage Disequilibrium report
CAPZA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for CAPZA3 Gene

Disorders for CAPZA3 Gene

Relevant External Links for CAPZA3

Genetic Association Database (GAD)
CAPZA3
Human Genome Epidemiology (HuGE) Navigator
CAPZA3
genes like me logo Genes that share disorders with CAPZA3: view

No data available for UniProtKB/Swiss-Prot for CAPZA3 Gene

Publications for CAPZA3 Gene

  1. Molecular cloning and characterization of the human orthologue of male germ cell-specific actin capping protein alpha3 (cpalpha3). (PMID: 12029070) Miyagawa Y. … Nishimune Y. (Mol. Hum. Reprod. 2002) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for CAPZA3 Gene

Sources for CAPZA3 Gene

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