Aliases for CAPZA3 Gene
External Ids for CAPZA3 Gene
Previous GeneCards Identifiers for CAPZA3 Gene
This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAPZA3 Gene
CAPZA3 (Capping Protein (Actin Filament) Muscle Z-Line, Alpha 3) is a Protein Coding gene. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Cell cycle_Spindle assembly and chromosome separation. GO annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.
UniProtKB/Swiss-Prot for CAPZA3 Gene
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).