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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPZA3 Gene

protein-coding   GIFtS: 49
GCID: GC12P018891

Capping Protein (Actin Filament) Muscle Z-Line, Alpha 3

  Search for CAPZA3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Capping Protein (Actin Filament) Muscle Z-Line, Alpha 31 2     Gsg32
Germ Cell-Specific Protein 32 3     F-Actin Capping Protein Alpha-3 Subunit2
CP-alpha-32 3     F-Actin-Capping Protein Subunit Alpha-32
CapZ Alpha-32 3     CAPAA33
CAPPA32 5     GSG33

External Ids:    HGNC: 242051   Entrez Gene: 936612   Ensembl: ENSG000001779387   OMIM: 6087225   UniProtKB: Q96KX23   

Export aliases for CAPZA3 gene to outside databases

Previous GC identifers: GC12P018782 GC12P018660


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAPZA3 Gene:
This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded
protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were
found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta
subunits. This protein may be important in determining sperm architecture and male fertility. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CAPZA3 Gene: 
CAPZA3 (capping protein (actin filament) muscle Z-line, alpha 3) is a protein-coding gene. Among its related super-pathways are Cytoskeleton remodeling Neurofilaments and Cell cycle Spindle assembly and chromosome separation. GO annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.

UniProtKB/Swiss-Prot: CAZA3_HUMAN, Q96KX2
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
(barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as
gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of
spermatid (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPZA3 gene promoter:
         AML1a   Nkx2-2   HSF1 (long)   Cdc5   NF-AT   HOXA5   FOXJ2 (long isoform)   HSF1short   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPZA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPZA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPZA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

CAPZA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPZA3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P018891:  view genomic region     (about GC identifiers)

Start:
18,891,045 bp from pter      End:
18,892,122 bp from pter
Size:
1,078 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAZA3_HUMAN, Q96KX2 (See protein sequence)
Recommended Name: F-actin-capping protein subunit alpha-3  
Size: 299 amino acids; 35025 Da
Subunit: Heterodimer of an alpha and a beta subunit (By similarity). Component of the WASH complex, composed of
F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB),
WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and
CCDC53
Secondary accessions: Q969J0

Explore the universe of human proteins at neXtProt for CAPZA3: NX_Q96KX2

Explore proteomics data for CAPZA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KX2

  • CAPZA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAPZA3 Protein Expression
    REFSEQ proteins: NP_201585.1  
    ENSEMBL proteins: 
     ENSP00000326238  

    Human Recombinant Protein Products for CAPZA3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom Protein Services for CAPZA3
    GenScript Custom Purified and Recombinant Proteins Services for CAPZA3
    Novus Biologicals CAPZA3 Proteins
    Novus Biologicals CAPZA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0008290F-actin capping protein complex IEA--
    GO:0016020membrane IEA--
    GO:0030863cortical cytoskeleton IEA--
    GO:0071203WASH complex IEA--

    CAPZA3 for ontologies           About GeneDecksing



    CAPZA3 Antibody Products: 
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    Abcam antibodies for CAPZA3
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    LSBio Antibodies in human, mouse, rat for CAPZA3 

    Assay Products for CAPZA3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR017865 F-actin_cap_asu_CS
     IPR002189 WASH_F-actin_cap_alpha

    Graphical View of Domain Structure for InterPro Entry Q96KX2

    ProtoNet protein and cluster: Q96KX2

    1 Blocks protein domain: IPB002189 F-actin capping protein

    UniProtKB/Swiss-Prot: CAZA3_HUMAN, Q96KX2
    Similarity: Belongs to the F-actin-capping protein alpha subunit family


    CAPZA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAZA3_HUMAN, Q96KX2
    Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
    (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as
    gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of
    spermatid (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    CAPZA3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CAPZA3:
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Capza3):
     reproductive system 

    CAPZA3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAPZA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAPZA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPZA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPZA3 

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CAPZA3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CAPZA3 (see all 6)
    OriGene ORF clones in mouse, rat for CAPZA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAPZA3 (NM_033328)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPZA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA3
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPZA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAPZA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments0.91
    Cytoplasmic microtubules0.32
    2Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CAPZA3
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for CAPZA3
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments



    CAPZA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAPZA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for CAPZA3 (Q96KX23 ENSP000003262384) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPZA2P477553, ENSP000003549474I2D: score=1 STRING: ENSP00000354947
    ACTG1P632613, ENSP000003315144I2D: score=1 STRING: ENSP00000331514
    ADD1ENSP000002647584STRING: ENSP00000264758
    ADD2ENSP000002644364STRING: ENSP00000264436
    CAPGENSP000002638674STRING: ENSP00000263867
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007286spermatid development IEA--
    GO:0030036actin cytoskeleton organization IEA--
    GO:0051693actin filament capping IEA--

    CAPZA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAPZA3 (CAZA3)

    Search CenterWatch for drugs/clinical trials and news about CAPZA3 / CAZA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAPZA3 gene: 
    NM_033328.2  

    Unigene Cluster for CAPZA3:

    Capping protein (actin filament) muscle Z-line, alpha 3
    Hs.131288  [show with all ESTs]
    Unigene Representative Sequence: BM553031
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000317658(uc001rdy.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPZA3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CAPZA3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAPZA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPZA3
    Clone
    Products:
         
    OriGene clones in human, mouse for CAPZA3 (see all 6)
    OriGene ORF clones in mouse, rat for CAPZA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAPZA3 (NM_033328)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPZA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA3
    Sirion Biotech Customized lentivirus for stable overexpression of CAPZA3 
                         Customized lentivirus expression plasmids for stable overexpression of CAPZA3 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CAPZA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAPZA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPZA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPZA3

    Additional mRNA sequence: 

    AB053259.1 AK058174.1 BC016745.2 

    1 DOTS entry:

    DT.406966 

    20 AceView cDNA sequences:

    AK058174 CD359623 NM_033328 BM553031 BM554108 BC016745 AB053259 AI798168 
    BI462232 BG772483 BP370577 AI018424 AA923335 AI654717 AI214488 AI027287 
    AA973833 AI018423 BP371336 BU569656 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPZA3 expression in normal human tissues (normalized intensities)      CAPZA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGAAAAA
    CAPZA3 Expression
    About this image


    CAPZA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Elongated Spermatid Seminiferous Tubules
             sperm   
     
     Gonad
             Elongated Spermatid Seminiferous Tubules

    See CAPZA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPZA3

    SOURCE GeneReport for Unigene cluster: Hs.131288

    UniProtKB/Swiss-Prot: CAZA3_HUMAN, Q96KX2
    Tissue specificity: Expressed exclusively in testis and sperm. Highest expression is found in the neck region of
    ejaculated sperm with lower levels found in the tail and postacrosome region

        SABiosciences Custom PCR Arrays for CAPZA3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPZA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPZA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CAPZA3 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capza31 , 5 capping protein (actin filament) muscle Z-line, alpha more1, 5 84.73(n)1
    91.3(a)1
      6 (69.77 cM)5
    123441  NM_007605.41  NP_031631.31 
     1400415575 
    chicken
    (Gallus gallus)
    Aves CAPZA31 capping protein (actin filament) muscle Z-line, alpha more 54.7(n)
    39.93(a)
      427929  XM_425501.3  XP_425501.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAPZA36
    --
    Uncharacterized protein
    40(a)
    31(a)
    1 ↔ 1
    possible ortholog
    5(9512913-9513740)
    GL343392.1(799049-805633)
    zebrafish
    (Danio rerio)
    Actinopterygii capza1b6
    capza1a6
    capping protein (actin filament) muscle Z-line, al...
    capping protein (actin filament) muscle Z-line, al...
    35(a)
    35(a)
    many → 1
    many → 1
    8(28660917-28669785)
    6(48263842-48287992)
    fruit fly
    (Drosophila melanogaster)
    Insecta cpa6
    capping protein alpha
    32(a)
    1 → many
    2R(16945276-16947388)
    worm
    (Caenorhabditis elegans)
    Secernentea cap-16
    F-actin-capping protein subunit alpha
    28(a)
    1 → many
    IV(7228337-7230225)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAP16
    Alpha subunit of the capping protein (CP) heterodi...
    23(a)
    1 → many
    XI(429302-430108)


    ENSEMBL Gene Tree for CAPZA3 (if available)
    TreeFam Gene Tree for CAPZA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAPZA3 gene
    CAPZA12  CAPZA22  
    2 SIMAP similar genes for CAPZA3 using alignment to 1 protein entry:     CAZA3_HUMAN:
    CAPZA1    CAPZA2

    CAPZA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in CAPZA3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs768404441,2
    C,F--18661613(+) AAAAAT/CCTAGC 1 -- ds50011Minor allele frequency- C:0.05EA 120

    HapMap Linkage Disequilibrium report for CAPZA3 (18891045 - 18892122 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CAPZA3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CAPZA3
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPZA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CAPZA3 for disorders           About MalaCards
    OMIM gene information: 608722    OMIM disorders: --


    CAPZA3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAPZA3
    Human Genome Epidemiology (HuGE) Navigator: CAPZA3 (3 documents)

    Export disorders for CAPZA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPZA3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CAPZA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the human orthologue of male germ cell-specific actin capping protein alpha3 (cpalpha3). (PubMed id 12029070)1, 2, 3, 9 Miyagawa Y.... Nishimune Y. (2002)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    7. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PubMed id 19922875)2 Derivery E.... Gautreau A. (2009)
    8. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Genomic analysis of male germ cell-specific actin capping protein alpha. (PubMed id 10524250)1 Yoshimura Y....Nishimune Y. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93661 HGNC: 24205 AceView: CAPZA3 Ensembl:ENSG00000177938 euGenes: HUgn93661
    ECgene: CAPZA3 H-InvDB: CAPZA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPZA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAPZA3 gene:
    Search GeneIP for patents involving CAPZA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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