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Aliases for CAPZA2 Gene

Aliases for CAPZA2 Gene

  • Capping Protein (Actin Filament) Muscle Z-Line, Alpha 2 2 3
  • F-Actin Capping Protein Alpha-2 Subunit 2 3
  • CapZ Alpha-2 3 4
  • CAPPA2 3 6
  • F-Actin-Capping Protein Subunit Alpha-2 3
  • CAPZ 3

External Ids for CAPZA2 Gene

Summaries for CAPZA2 Gene

Entrez Gene Summary for CAPZA2 Gene

  • The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPZA2 Gene

CAPZA2 (Capping Protein (Actin Filament) Muscle Z-Line, Alpha 2) is a Protein Coding gene. Among its related pathways are Hemostasis and Advanced glycosylation endproduct receptor signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.

UniProtKB/Swiss-Prot for CAPZA2 Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments

Gene Wiki entry for CAPZA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPZA2 Gene

Genomics for CAPZA2 Gene

Genomic Location for CAPZA2 Gene

Start:
116,811,070 bp from pter
End:
116,922,049 bp from pter
Size:
110,980 bases
Orientation:
Plus strand

Genomic View for CAPZA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPZA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZA2 Gene

Regulatory Elements for CAPZA2 Gene

Proteins for CAPZA2 Gene

  • Protein details for CAPZA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47755-CAZA2_HUMAN
    Recommended name:
    F-actin-capping protein subunit alpha-2
    Protein Accession:
    P47755
    Secondary Accessions:
    • B4DG50

    Protein attributes for CAPZA2 Gene

    Size:
    286 amino acids
    Molecular mass:
    32949 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts with RCSD1/CAPZIP.

    Alternative splice isoforms for CAPZA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPZA2 Gene

Proteomics data for CAPZA2 Gene at MOPED

Post-translational modifications for CAPZA2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys19, Lys133, Lys226, Lys273, Lys278, and Lys281

Other Protein References for CAPZA2 Gene

No data available for DME Specific Peptides for CAPZA2 Gene

Domains for CAPZA2 Gene

Protein Domains for CAPZA2 Gene

UniProtKB/Swiss-Prot:

CAZA2_HUMAN
Family:
  • Belongs to the F-actin-capping protein alpha subunit family.:
    • P47755
genes like me logo Genes that share domains with CAPZA2: view

No data available for Gene Families for CAPZA2 Gene

Function for CAPZA2 Gene

Molecular function for CAPZA2 Gene

GENATLAS Biochemistry: actin-capping protein Z,alpha 2 subunit,amplified in the glioblastoma
UniProtKB/Swiss-Prot Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments

Gene Ontology (GO) - Molecular Function for CAPZA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CAPZA2: view

miRNA for CAPZA2 Gene

miRTarBase miRNAs that target CAPZA2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAPZA2 Gene

Localization for CAPZA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPZA2 Gene COMPARTMENTS Subcellular localization image for CAPZA2 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
extracellular 4
nucleus 2

Gene Ontology (GO) - Cellular Components for CAPZA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0008290 F-actin capping protein complex IEA --
GO:0015629 actin cytoskeleton TAS 9331217
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CAPZA2: view

Pathways for CAPZA2 Gene

genes like me logo Genes that share pathways with CAPZA2: view

Pathways by source for CAPZA2 Gene

Gene Ontology (GO) - Biological Process for CAPZA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9331217
GO:0006928 movement of cell or subcellular component TAS 9331217
GO:0007596 blood coagulation TAS --
GO:0030036 actin cytoskeleton organization --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with CAPZA2: view

Compounds for CAPZA2 Gene

(1) Novoseek inferred chemical compound relationships for CAPZA2 Gene

Compound -log(P) Hits PubMed IDs
calcium 1.92 1
genes like me logo Genes that share compounds with CAPZA2: view

Transcripts for CAPZA2 Gene

Unigene Clusters for CAPZA2 Gene

Capping protein (actin filament) muscle Z-line, alpha 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: -
SP6: - -

Relevant External Links for CAPZA2 Gene

GeneLoc Exon Structure for
CAPZA2
ECgene alternative splicing isoforms for
CAPZA2

Expression for CAPZA2 Gene

mRNA expression in normal human tissues for CAPZA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPZA2 Gene

SOURCE GeneReport for Unigene cluster for CAPZA2 Gene Hs.446123

genes like me logo Genes that share expressions with CAPZA2: view

Orthologs for CAPZA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAPZA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPZA2 36
  • 99.65 (n)
  • 100 (a)
CAPZA2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPZA2 36
  • 95.1 (n)
  • 98.6 (a)
CAPZA2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPZA2 36
  • 95.92 (n)
  • 99.3 (a)
CAPZA2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capza2 36
  • 93.82 (n)
  • 98.25 (a)
Capza2 16
Capza2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPZA2 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPZA2 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capza2 36
  • 93.82 (n)
  • 98.25 (a)
chicken
(Gallus gallus)
Aves CAPZA2 36
  • 89.98 (n)
  • 95.1 (a)
CAPZA2 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPZA2 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21413 36
tropical clawed frog
(Silurana tropicalis)
Amphibia capza2 36
  • 83.22 (n)
  • 91.26 (a)
Str.10827 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11052 36
fruit fly
(Drosophila melanogaster)
Insecta cpa 37
  • 59 (a)
OneToMany
CG10540 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea cap-1 37
  • 51 (a)
OneToMany
cap-1 38
  • 53 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR007C 36
  • 44.44 (n)
  • 32.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP1 36
  • 46.35 (n)
  • 33.86 (a)
CAP1 37
  • 28 (a)
OneToMany
CAP1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13453g 36
  • 45.47 (n)
  • 31.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03911 36
  • 45.57 (n)
  • 36.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8055 37
  • 52 (a)
OneToMany
Species with no ortholog for CAPZA2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CAPZA2 Gene

ENSEMBL:
Gene Tree for CAPZA2 (if available)
TreeFam:
Gene Tree for CAPZA2 (if available)

Paralogs for CAPZA2 Gene

Paralogs for CAPZA2 Gene

Selected SIMAP similar genes for CAPZA2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CAPZA2 Gene

genes like me logo Genes that share paralogs with CAPZA2: view

Variants for CAPZA2 Gene

Sequence variations from dbSNP and Humsavar for CAPZA2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4808 -- 116,888,186(+) GTTTT(C/T)AATGG reference, synonymous-codon
rs41796 -- 116,870,185(+) AGATA(A/C/T)AATGC intron-variant
rs42231 -- 116,863,044(+) CGTGC(C/G)TGGGA intron-variant
rs964449 -- 116,894,766(+) TTGTG(A/G)CTGGT intron-variant
rs1049618 -- 116,918,662(+) GTCTC(A/G)GTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CAPZA2 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv831107 CNV Gain 17160897
dgv7465n71 CNV Gain 21882294

Relevant External Links for CAPZA2 Gene

HapMap Linkage Disequilibrium report
CAPZA2

Disorders for CAPZA2 Gene

No disorders were found for CAPZA2 Gene.

No data available for UniProtKB/Swiss-Prot for CAPZA2 Gene

Publications for CAPZA2 Gene

  1. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PMID: 7665558) Barron-Casella E.A. … Casella J.F. (J. Biol. Chem. 1995) 3 4 23
  2. The phosphorylation of CapZ-interacting protein (CapZIP) by stress- activated protein kinases triggers its dissociation from CapZ. (PMID: 15850461) Eyers C.E. … Cohen P. (Biochem. J. 2005) 4 23
  3. Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. (PMID: 9331217) Hart M.C. … Cooper J.A. (Cell Motil. Cytoskeleton 1997) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CAPZA2 Gene

Sources for CAPZA2 Gene

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