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CAPZA2 Gene

protein-coding   GIFtS: 61
GCID: GC07P116451

Capping Protein (Actin Filament) Muscle Z-Line, Alpha 2

  Search for CAPZA2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Capping Protein (Actin Filament) Muscle Z-Line, Alpha 21 2
F-Actin Capping Protein Alpha-2 Subunit1 2
CapZ Alpha-22 3
CAPPA22 5
CAPZ2
F-Actin-Capping Protein Subunit Alpha-22

External Ids:    HGNC: 14901   Entrez Gene: 8302   Ensembl: ENSG000001988987   OMIM: 6015715   UniProtKB: P477553   

Export aliases for CAPZA2 gene to outside databases

Previous GC identifers: GC07P114980 GC07P116043 GC07P116057 GC07P116096 GC07P116289 GC07P110868


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAPZA2 Gene:
The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha
subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z
regulates the growth of the actin filaments at the barbed end. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAPZA2 Gene:
CAPZA2 (capping protein (actin filament) muscle Z-line, alpha 2) is a protein-coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.

UniProtKB/Swiss-Prot: CAZA2_HUMAN, P47755
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
(barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as
gelsolin and severin), these proteins do not sever actin filaments

Gene Wiki entry for CAPZA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAPZA2 gene promoter:
         GR   STAT5B   Sox5   POU3F1   HNF-3beta   SRY   E2F-1   E2F   GR-alpha   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CAPZA2 promoter sequence
   Search Chromatin IP Primers for CAPZA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPZA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.2-q31.3   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31.2-q31.3

CAPZA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPZA2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P116451:  view genomic region     (about GC identifiers)

Start:
116,451,124 bp from pter      End:
116,562,103 bp from pter
Size:
110,980 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 115,898,010-115,954,766     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAZA2_HUMAN, P47755 (See protein sequence)
Recommended Name: F-actin-capping protein subunit alpha-2  
Size: 286 amino acids; 32949 Da
Subunit: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping
protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1,
WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53.
Interacts with RCSD1/CAPZIP
Secondary accessions: B4DG50
Alternative splicing: 2 isoforms:  P47755-1   P47755-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAPZA2: NX_P47755

Explore proteomics data for CAPZA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19, Lys133, Lys226, Lys273, Lys278, Lys281
  • Modification sites at PhosphoSitePlus

  • See CAPZA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006127.1  
    ENSEMBL proteins: 
     ENSP00000420640   ENSP00000418262   ENSP00000354947   ENSP00000408150   ENSP00000419484  
     ENSP00000395395   ENSP00000393509  
    Reactome Protein details: P47755

    CAPZA2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for CAPZA2
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    OriGene MassSpec for CAPZA2
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    Novus Biologicals CAPZA2 Proteins
    Novus Biologicals CAPZA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CAPZA2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CAPZA2 

    CAPZA2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CAPZA2
    LSBio Antibodies in human, mouse, rat for CAPZA2

    CAPZA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CAPZA2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017865 F-actin_cap_asu_CS
     IPR002189 CapZ_alpha

    Graphical View of Domain Structure for InterPro Entry P47755

    ProtoNet protein and cluster: P47755

    1 Blocks protein domain: IPB002189 F-actin capping protein

    UniProtKB/Swiss-Prot: CAZA2_HUMAN, P47755
    Similarity: Belongs to the F-actin-capping protein alpha subunit family


    Find genes that share domains with CAPZA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAZA2_HUMAN, P47755
    Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
    (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as
    gelsolin and severin), these proteins do not sever actin filaments

         Genatlas biochemistry entry for CAPZA2:
    actin-capping protein Z,alpha 2 subunit,amplified in the glioblastoma

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CAPZA2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPZA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAPZA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPZA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPZA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAPZA2:
    hsa-mir-103a-3p (MIRT027222), hsa-mir-16-5p (MIRT031933)

    Block miRNA regulation of human, mouse, rat CAPZA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPZA2 (see all 25):
    hsa-miR-642a hsa-miR-15a hsa-miR-374a hsa-miR-3684 hsa-miR-373* hsa-miR-3159 hsa-miR-103a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidCAPZA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAPZA2
    Predesigned siRNA for gene silencing in human, mouse, rat CAPZA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAPZA2

    Clone
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    OriGene clones in human, mouse for CAPZA2 (see all 6)
    OriGene ORF clones in mouse, rat for CAPZA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAPZA2 (NM_006136)
    Sino Biological Human cDNA Clone for CAPZA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPZA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CAPZA2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAPZA2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPZA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    extracellular4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0008290F-actin capping protein complex IEA--
    GO:0015629actin cytoskeleton TAS9331217

    Find genes that share ontologies with CAPZA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAPZA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    2Hemostasis
    Hemostasis0.43
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production
    4Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation
    5Advanced glycosylation endproduct receptor signaling
    Advanced glycosylation endproduct receptor signaling


    Find genes that share SuperPaths with CAPZA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CAPZA2
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments


    2 Reactome Pathways for CAPZA2
        Advanced glycosylation endproduct receptor signaling
    Factors involved in megakaryocyte development and platelet production


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAPZA2
    Interactions:

        Search GeneGlobe Interaction Network for CAPZA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAPZA2 (P477553 ENSP000003549474) via UniProtKB, MINT, STRING, and/or I2D (see all 221)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=1 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=1 STRING: ENSP00000291295
    PDCD11Q146903, ENSP000003588124I2D: score=3 STRING: ENSP00000358812
    SSRP1Q089453, ENSP000002784124I2D: score=3 STRING: ENSP00000278412
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9331217
    GO:0006928cellular component movement TAS9331217
    GO:0007596blood coagulation TAS--
    GO:0030036actin cytoskeleton organization IEA--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with CAPZA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAPZA2 (CAZA2)

    1 Novoseek inferred chemical compound relationship for CAPZA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 1.92 1 7540176 (1)



    Find genes that share compounds with CAPZA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAPZA2 gene: 
    NM_006136.2  

    Unigene Cluster for CAPZA2:

    Capping protein (actin filament) muscle Z-line, alpha 2
    Hs.446123  [show with all ESTs]
    Unigene Representative Sequence: NM_006136
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464223 ENST00000484325(uc003vik.1) ENST00000361183(uc003vil.3 uc011knk.2)
    ENST00000414148 ENST00000449080 ENST00000490693 ENST00000426421 ENST00000461878
    ENST00000417431 ENST00000466023 ENST00000464669 ENST00000465607 ENST00000496161
    ENST00000458284
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CAPZA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPZA2 (see all 25):
    hsa-miR-642a hsa-miR-15a hsa-miR-374a hsa-miR-3684 hsa-miR-373* hsa-miR-3159 hsa-miR-103a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidCAPZA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CAPZA2
    Predesigned siRNA for gene silencing in human, mouse, rat CAPZA2
    Clone
    Products:
         
    OriGene clones in human, mouse for CAPZA2 (see all 6)
    OriGene ORF clones in mouse, rat for CAPZA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAPZA2 (NM_006136)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPZA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CAPZA2
    OriGene qSTAR qPCR primer pairs in human, mouse for CAPZA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAPZA2
      QuantiTect SYBR Green Assays in human, mouse, rat CAPZA2
      QuantiFast Probe-based Assays in human, mouse, rat CAPZA2

    Additional mRNA sequence: 

    AK222989.1 AK223004.1 AK293405.1 AK294409.1 AK311406.1 AK314808.1 AK315915.1 BC005338.1 
    BC015963.1 BT006735.1 DQ655955.2 DQ655956.2 U03269.1 U03851.1 

    Selected DOTS entries (see all 26):

    DT.448218  DT.95230583  DT.92460809  DT.100044230  DT.100892016  DT.440613  DT.100892004  DT.92460794 
    DT.95230659  DT.95230665  DT.100892049  DT.92460801  DT.95230661  DT.99977675  DT.100892007  DT.95230666 
    DT.99958958  DT.100760626  DT.121110625  DT.75122880  DT.86850635  DT.92460799  DT.92460810  DT.95230664 

    Selected AceView cDNA sequences (see all 669):

    BU167748 AI275896 BM720925 BU951566 BX501293 BF691651 AI917193 CR590988 
    BQ961551 BX282155 BE138832 BM458113 AA337397 BM782822 BU736719 CA414865 
    BM769377 BM468304 AI922454 BM757019 BF753682 CB155502 BG610655 AU077173 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
    SP1:        -     -           -                                   -                                       
    SP2:              -           -                                                                           
    SP3:                          -                                                                           
    SP4:                          -                       -     -                                             
    SP5:                                                              -                                       


    ECgene alternative splicing isoforms for CAPZA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAPZA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTAATT
    CAPZA2 Expression
    About this image


    CAPZA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
    CAPZA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPZA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446123
        Custom PCR Arrays for CAPZA2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CAPZA2
    OriGene qSTAR qPCR primer pairs in human, mouse for CAPZA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAPZA2
    QuantiTect SYBR Green Assays in human, mouse, rat CAPZA2
    QuantiFast Probe-based Assays in human, mouse, rat CAPZA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPZA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CAPZA2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capza21 , 5 capping protein (actin filament) muscle Z-line, alpha more1, 5 93.82(n)1
    98.25(a)1
      6 (7.96 cM)5
    123431  NM_007604.21  NP_031630.11 
     176362345 
    chicken
    (Gallus gallus)
    Aves CAPZA21 capping protein (actin filament) muscle Z-line, alpha more 89.98(n)
    95.1(a)
      417771  NM_001004380.1  NP_001004380.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAPZA26
    capping protein (actin filament) muscle Z-line, al...
    91(a)
    1 ↔ 1
    5(61269444-61303202)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.214132 Xenopus laevis transcribed sequence with moderate similarity more 82.93(n)    BU916756.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.110522 Oncorhynchus mykiss transcribed sequence with moderate more 78.24(n)    BX879707.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105403 actin cytoskeleton organization and
    biogenesis more
    61(a)   57B16   --
    worm
    (Caenorhabditis elegans)
    Secernentea cap-13   -- 53(a)   IV(7228891-7230410)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAP1(YKL007W)4
    CAP11
    Alpha subunit of the capping protein (CP) heterodimer more4
    CAP11
    46.35(n)1
    33.86(a)1
      11(429302-430108)4
    8538621, 4  NP_012918.11, 4 


    ENSEMBL Gene Tree for CAPZA2 (if available)
    TreeFam Gene Tree for CAPZA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAPZA2 gene
    CAPZA12  CAPZA32  
    2 SIMAP similar genes for CAPZA2 using alignment to 7 protein entries:     CAZA2_HUMAN (see all proteins):
    CAPZA1    CAPZA3

    Find genes that share paralogs with CAPZA2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CAPZA2
    PGOHUM00000246919


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAPZA2 (see all 946)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163368891,2
    F--116500614(+) TTTATT/CTGATA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1130908501,2
    F--116500715(+) GTTCCC/TCACGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs737141921,2
    C--116500719(+) CTCACG/AGAATC 1 -- us2k13Minor allele frequency- A:0.07WA NA 240
    rs1857160491,2
    --116500792(+) CTGGCA/GTCAGC 1 -- us2k10--------
    rs1498533431,2
    --116500877(+) AACAAC/TTTCGT 1 -- us2k10--------
    rs794305361,2
    C--116500899(+) TCCCAA/GTTGAT 1 -- us2k10--------
    rs1906266821,2
    --116500944(+) TCTCAC/TAAACT 1 -- us2k10--------
    rs1817344571,2
    --116501054(+) TCCACA/TGCTTC 1 -- us2k10--------
    rs1390812031,2
    --116501060(+) GCTTCA/GTGGGA 1 -- us2k10--------
    rs1440059711,2
    --116501073(+) TACTTA/TTTAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAPZA2 (116451124 - 116562103 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CAPZA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831107CNV Gain17160897
    dgv7465n71CNV Gain21882294
    nsv7405OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAPZA2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPZA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601571    OMIM disorders: --


    Find genes that share disorders with CAPZA2           About GenesLikeMe


    Export disorders for CAPZA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAPZA2 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with CAPZA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PubMed id 7665558)1, 2, 9 Barron-Casella E.A.... Casella J.F. (J. Biol. Chem. 1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. (PubMed id 9331217)1, 2 Hart M.C.... Cooper J.A. (Cell Motil. Cytoskeleton 1997)
    6. The phosphorylation of CapZ-interacting protein (CapZIP) by stress- activated protein kinases triggers its dissociation from CapZ. (PubMed id 15850461)2, 9 Eyers C.E.... Cohen P. (Biochem. J. 2005)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 830 HGNC: 1490 AceView: CAPZA2 Ensembl:ENSG00000198898 euGenes: HUgn830
    ECgene: CAPZA2 H-InvDB: CAPZA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAPZA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAPZA2 gene:
    Search GeneIP for patents involving CAPZA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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