Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPZA2 Gene

protein-coding   GIFtS: 55
GCID: GC07P116451

capping protein (actin filament) muscle Z-line, alpha 2
 Explore 4 diseases affiliated with
CAPZA2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CAPZA2    

Aliases
for CAPZA2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Capping Protein (Actin Filament) Muscle Z-Line, Alpha 21 2
CAPPA21 2 5
CAPZ1 2
CapZ Alpha-22 3
F-Actin Capping Protein Alpha-2 Subunit2
F-Actin-Capping Protein Subunit Alpha-22

External Ids:    HGNC: 14901   Entrez Gene: 8302   Ensembl: ENSG000001988987   OMIM: 6015715   UniProtKB: P477553   

Export aliases for CAPZA2 gene to outside databases

Previous GC identifers: GC07P114980 GC07P116043 GC07P116057 GC07P116096 GC07P116289 GC07P110868


Summaries
for CAPZA2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CAPZA2:
The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha
subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates
the growth of the actin filaments at the barbed end. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAZA2_HUMAN, P47755
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
(barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin
and severin), these proteins do not sever actin filaments

Gene Wiki entry for CAPZA2


Genomic Views
for CAPZA2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPZA2 gene promoter:
         GR   STAT5B   Sox5   POU3F1   HNF-3beta   SRY   E2F-1   E2F   GR-alpha   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CAPZA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPZA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPZA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.2-q31.3   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31.2-q31.3

CAPZA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPZA2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P116451:  view genomic region     (about GC identifiers)

Start:
 116,451,124 bp from pter      End:
 116,559,315 bp from pter
Size:
 108,192 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 115,898,010-115,954,766     

Proteins
for CAPZA2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CAZA2_HUMAN, P47755 (See protein sequence)
Recommended Name: F-actin-capping protein subunit alpha-2  
Size: 286 amino acids; 32949 Da
Subunit: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein
subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P,
WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts with
RCSD1/CAPZIP

Explore the universe of human proteins at neXtProt for CAPZA2: NX_P47755

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P47755

    • CAPZA2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006127.1  
    ENSEMBL proteins: 
     ENSP00000420640   ENSP00000418262   ENSP00000354947   ENSP00000408150   ENSP00000419484  
     ENSP00000395395   ENSP00000393509  
    Reactome Protein details: P47755
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CAPZA2
    OriGene Protein Over-expression Lysate: CAPZA2
    OriGene Custom Protein Services for CAPZA2 
    GenScript Custom Purified and Recombinant Proteins Services for CAPZA2
    Novus Biologicals CAPZA2 Proteins
    Novus Biologicals CAPZA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0008290F-actin capping protein complex IEA--
    GO:0015629actin cytoskeleton TAS9331217


    CAPZA2 for ontologies           About GeneDecksing



    CAPZA2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CAPZA2 
    GenScript Custom Superior Antibodies Services for CAPZA2
    Novus Biologicals CAPZA2 Antibodies
    Search for Antibodies for CAPZA2 at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for CAPZA2

    Assay Products for CAPZA2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAPZA2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CAPZA2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CAPZA2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR017865 F-actin_cap_asu_CS
     IPR002189 WASH_F-actin_cap_alpha

    Graphical View of Domain Structure for InterPro Entry P47755

    ProtoNet protein and cluster: P47755

    1 Blocks protein family: IPB002189 F-actin capping protein

    UniProtKB/Swiss-Prot: CAZA2_HUMAN, P47755
    Similarity: Belongs to the F-actin-capping protein alpha subunit family


    Function
    for CAPZA2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CAZA2_HUMAN, P47755
    Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
    (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin
    and severin), these proteins do not sever actin filaments

         Genatlas biochemistry entry for CAPZA2:
    actin-capping protein Z,alpha 2 subunit,amplified in the glioblastoma

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CAPZA2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPZA2
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPZA2 (see all 25):
    hsa-miR-642a hsa-miR-15a hsa-miR-374a hsa-miR-3684 hsa-miR-373* hsa-miR-3159 hsa-miR-103a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: CAPZA2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPZA2 (see all 7)
    OriGene shRNA RFP: CAPZA2
    OriGene siRNA: CAPZA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPZA2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CAPZA2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPZA2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPZA2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CAPZA2 (NM_006136)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPZA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CAPZA2
    Search LifeMap BioReagents cell lines for CAPZA2

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CAPZA2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----


    CAPZA2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CAPZA2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Neurofilaments
    		Cytoskeleton remodeling Neurofilaments1.00
    		Cytoplasmic microtubules0.32
    		Cytoskeleton remodeling_Neurofilaments0.91
    2Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    3Immune System
    		Immune System1.00
    		Innate Immune System0.46
    4Factors involved in megakaryocyte development and platelet production
    		Factors involved in megakaryocyte development and platelet production1.00
    5Advanced glycosylation endproduct receptor signaling
    		Advanced glycosylation endproduct receptor signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for CAPZA2
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for CAPZA2
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments

    5        Reactome Pathways for CAPZA2
        Hemostasis
    Advanced glycosylation endproduct receptor signaling
    Factors involved in megakaryocyte development and platelet production
    Immune System
    Innate Immune System



    CAPZA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAPZA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for CAPZA2 (P477553 ENSP000003549474) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    APCP250543, ENSP000002574304I2D: score=2 STRING: ENSP00000257430
    RBBP6Q7Z6E93, ENSP000003178724I2D: score=2 STRING: ENSP00000317872
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9331217
    GO:0006928cellular component movement TAS9331217
    GO:0007596blood coagulation TAS--
    GO:0030036actin cytoskeleton organization IEA--
    GO:0045087innate immune response TAS--


    CAPZA2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CAPZA2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAPZA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAPZA2
    1 Novoseek chemical compound relationship for CAPZA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 1.92 1 7540176 (1)

    Search CenterWatch for drugs/clinical trials and news about CAPZA2 / CAZA2 

    Transcripts
    for CAPZA2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CAPZA2 gene: 
    NM_006136.2  

    Unigene Cluster for CAPZA2:

    Capping protein (actin filament) muscle Z-line, alpha 2
    Hs.446123  [show with all ESTs]
    Unigene Representative Sequence: NM_006136
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464223 ENST00000484325(uc003vik.1) ENST00000361183(uc003vil.3 uc011knk.2)
    ENST00000414148 ENST00000449080 ENST00000490693 ENST00000426421 ENST00000461878
    ENST00000417431 ENST00000466023 ENST00000464669 ENST00000465607 ENST00000496161
    ENST00000458284

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CAPZA2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPZA2
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPZA2 (see all 25):
    hsa-miR-642a hsa-miR-15a hsa-miR-374a hsa-miR-3684 hsa-miR-373* hsa-miR-3159 hsa-miR-103a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: CAPZA2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPZA2 (see all 7)
    OriGene shRNA RFP: CAPZA2
    OriGene siRNA: CAPZA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPZA2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPZA2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPZA2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CAPZA2 (NM_006136)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPZA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPZA2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAPZA2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPZA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPZA2

    Additional cDNA sequence: 

    AK222989.1 AK223004.1 AK293405.1 AK294409.1 AK311406.1 AK314808.1 AK315915.1 BC005338.1 
    BC015963.1 BT006735.1 DQ655955.2 DQ655956.2 U03269.1 U03851.1 

    24/25 DOTS entries (see all 25):

    DT.448218  DT.95230583  DT.92460809  DT.100044230  DT.100892016  DT.440613  DT.92460794  DT.95230659 
    DT.95230665  DT.100892004  DT.100892049  DT.92460801  DT.95230661  DT.99977675  DT.100892007  DT.99958958 
    DT.100760626  DT.121110625  DT.75122880  DT.86850635  DT.92460799  DT.92460810  DT.121110559  DT.92041602 

    24/669 AceView cDNA sequences (see all 669):

    BU190076 BM695118 AL548975 CB305673 CA396615 AA311775 CR601522 BF001429 
    BM747019 AA766326 BP345621 BU507172 AW439230 AI421580 AI862778 BE049332 
    BP377266 AU077173 AI349353 AI274752 CR607571 CR602265 BE889586 BU680200 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
    SP1:        -     -           -                                   -                                       
    SP2:              -           -                                                                           
    SP3:                          -                                                                           
    SP4:                          -                       -     -                                             
    SP5:                                                              -                                       


    ECgene alternative splicing isoforms for CAPZA2

    Expression
    for CAPZA2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPZA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTTTAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CAPZA2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePelvic MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePosterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CAPZA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPZA2

    SOURCE GeneReport for Unigene cluster: Hs.446123
        SABiosciences Custom PCR Arrays for CAPZA2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPZA2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAPZA2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPZA2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPZA2
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CAPZA2

    Orthologs
    for CAPZA2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAPZA2 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CAPZA21 capping protein (actin filament) muscle Z-line, alpha more 89.98(n)
    95.1(a)    		   417771  NM_001004380.1  NP_001004380.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CAPZA26
    		 --
    		 89(a)
    		 1 ↔ 1
    		 5(61286484-61303144)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.214132 Xenopus laevis transcribed sequence with moderate similarity more 82.93(n)    BU916756.1 
    rainbow trout
    (Oncorhynchus mykiss)    		 Actinopterygii Omy.110522 Oncorhynchus mykiss transcribed sequence with moderate more 78.24(n)    BX879707.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG105403 actin cytoskeleton organization and
    biogenesis more    		 61(a)   57B16   --
    worm
    (Caenorhabditis elegans)    		 Secernentea cap-13   -- 53(a)   IV(7228891-7230410)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CAP1(YKL007W)4
    CAP11    		 Alpha subunit of the capping protein (CP) heterodimer more4
    Cap1p1    		 45.95(n)1
    32.82(a)1    		   11(429302-430108)4
    8538621, 4  NP_012918.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G055206
    		 F-actin-capping protein subunit alpha
    		 23(a)
    		 1 → many
    		 3(1598547-1601437)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 F-actin-capping protein subunit alpha, putative, e...
    		 32(a)
    		 1 → many
    		 7(13073445-13077536)


    ENSEMBL Gene Tree for CAPZA2 (if available)
    TreeFam Gene Tree for CAPZA2 (if available) 

    Paralogs
    for CAPZA2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAPZA2 gene
    CAPZA12  CAPZA32  
    2 SIMAP similar genes for CAPZA2 using alignment to 8 protein entries:     CAZA2_HUMAN (see all proteins):
    CAPZA1    CAPZA3

    CAPZA2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CAPZA2
    PGOHUM00000246919


    Genomic Variants
    for CAPZA2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/790 NCBI SNPs in CAPZA2 are shown (see all 790)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1163368891,2
    		F,--116500614(+) TTTATT/CTGATA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1130908501,2
    		--116500715(+) GTTCCC/TCACGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs737141921,2
    		C,--116500719(+) CTCACG/AGAATC 1 -- us2k13Minor allele frequency- A:0.07WA NA 240
    rs1857160491,2
    		--116500792(+) CTGGCA/GTCAGC 1 -- us2k10--------
    rs1498533431,2
    		--116500877(+) AACAAC/TTTCGT 1 -- us2k10--------
    rs794305361,2
    		--116500899(+) TCCCAA/GTTGAT 1 -- us2k10--------
    rs1906266821,2
    		--116500944(+) TCTCAC/TAAACT 1 -- us2k10--------
    rs1817344571,2
    		--116501054(+) TCCACA/TGCTTC 1 -- us2k10--------
    rs1390812031,2
    		--116501060(+) GCTTCA/GTGGGA 1 -- us2k10--------
    rs1440059711,2
    		--116501073(+) TACTTA/TTTAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAPZA2 (116451124 - 116559315 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CAPZA2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAPZA2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPZA2

    Disorders / Diseases
    for CAPZA2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CAPZA2 for disorders           About GeneDecksing

    OMIM gene information: 601571    OMIM disorders: --

    4 diseases for CAPZA2:    About MalaCards
    endocarditis    glioblastoma    malaria    neuronitis


    Export disorders for CAPZA2 gene to outside databases

    Publications
    for CAPZA2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPZA2 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with CAPZA2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PubMed id 7665558)1, 2, 9 Barron-Casella E.A.... Casella J.F. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. (PubMed id 9331217)1, 2 Hart M.C.... Cooper J.A. (1997)
    6. The phosphorylation of CapZ-interacting protein (CapZIP) by stress- activated protein kinases triggers its dissociation from CapZ. (PubMed id 15850461)2, 9 Eyers C.E.... Cohen P. (2005)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for CAPZA2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CAPZA2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 830 HGNC: 1490 AceView: CAPZA2 Ensembl:ENSG00000198898 euGenes: HUgn830
    ECgene: CAPZA2 H-InvDB: CAPZA2

    Other Databases showing CAPZA2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CAPZA2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPZA2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CAPZA2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CAPZA2 gene:
    Search GeneIP for patents involving CAPZA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CAPZA2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CAPZA2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPZA2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPZA2  
     OriGene Protein Over-expression Lysate for CAPZA2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CAPZA2   OriGene 3'-UTR Clone for CAPZA2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPZA2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPZA2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CAPZA2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CAPZA2   OriGene Custom Protein Services for CAPZA2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAPZA2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAPZA2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPZA2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPZA2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPZA2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPZA2
     GenScript Custom Purified and Recombinant Proteins Services for CAPZA2 GenScript cDNA clones with any tag delivered in your preferred vector for CAPZA2
     GenScript Custom Assay Services for CAPZA2 GenScript Custom Superior Antibodies Services for CAPZA2
     GenScript Custom overexpressing Cell Line Services for CAPZA2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CAPZA2 promoter
     Search Chromatin IP Primers for CAPZA2
     RT2 qPCR Primer Assay in human, mouse, rat CAPZA2
     Search GNC Networks for CAPZA2
     SABiosciences Custom PCR Arrays for CAPZA2
     Search Tocris compounds for CAPZA2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CAPZA2 antibodies
     CAPZA2 proteins
     CAPZA2 lysates
     Search for Antibodies for CAPZA2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CAPZA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for CAPZA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CAPZA2
     SwitchGear 3'UTR luciferase reporter plasmids for CAPZA2
     SwitchGear Promoter luciferase reporter plasmids for CAPZA2
     Search ThermoFisher Antibodies for CAPZA2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CAPZA2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4