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Aliases for CAPZA2 Gene

Aliases for CAPZA2 Gene

  • Capping Actin Protein Of Muscle Z-Line Alpha Subunit 2 2 3 5
  • Capping Protein (Actin Filament) Muscle Z-Line, Alpha 2 2 3
  • F-Actin Capping Protein Alpha-2 Subunit 2 3
  • CapZ Alpha-2 3 4
  • F-Actin-Capping Protein Subunit Alpha-2 3
  • CAPPA2 3
  • CAPZ 3

External Ids for CAPZA2 Gene

Previous GeneCards Identifiers for CAPZA2 Gene

  • GC07P114980
  • GC07P116043
  • GC07P116057
  • GC07P116096
  • GC07P116289
  • GC07P116451
  • GC07P110868

Summaries for CAPZA2 Gene

Entrez Gene Summary for CAPZA2 Gene

  • The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPZA2 Gene

CAPZA2 (Capping Actin Protein Of Muscle Z-Line Alpha Subunit 2) is a Protein Coding gene. Among its related pathways are Advanced glycosylation endproduct receptor signaling and Innate Immune System. GO annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.

UniProtKB/Swiss-Prot for CAPZA2 Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Gene Wiki entry for CAPZA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPZA2 Gene

Genomics for CAPZA2 Gene

Regulatory Elements for CAPZA2 Gene

Enhancers for CAPZA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G116780 1.3 Ensembl ENCODE dbSUPER 21 -29.3 -29348 3.3 NFIB FEZF1 RAD21 TCF12 ZNF121 ELK1 SCRT2 FOS RCOR1 ZHX2 MET CAPZA2 ENSG00000235427 CFTR GC07P116736
GH07G116869 1.5 Ensembl ENCODE dbSUPER 13.6 +61.4 61405 6.1 HDGF ATF1 PKNOX1 ARNT CREB3L1 ZFP64 SIN3A YY1 ZNF766 ELK1 CAPZA2 LOC100418716
GH07G116861 1.4 ENCODE dbSUPER 11.3 +52.3 52290 3.1 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 CAPZA2 LOC100418716
GH07G116775 1.5 Ensembl ENCODE dbSUPER 8.5 -34.0 -34015 2.6 HDGF ATF1 PKNOX1 ARNT YY1 ZNF766 GATA2 FOS MCM3 NCOA1 MET ENSG00000243243 ENSG00000235427 ENSG00000243220 CAPZA2 GC07P116736
GH07G116930 1.1 Ensembl ENCODE 9.8 +119.6 119589 0.4 ELF3 CBX3 RB1 ZFP64 ZNF2 RAD21 RFX5 GATA2 SCRT2 ZNF143 CAPZA2 LOC105375465 ENSG00000252115 GC07M116910
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAPZA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPZA2 Gene

Chromosome:
7
Start:
116,811,070 bp from pter
End:
116,922,049 bp from pter
Size:
110,980 bases
Orientation:
Plus strand

Genomic View for CAPZA2 Gene

Genes around CAPZA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPZA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPZA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZA2 Gene

Proteins for CAPZA2 Gene

  • Protein details for CAPZA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47755-CAZA2_HUMAN
    Recommended name:
    F-actin-capping protein subunit alpha-2
    Protein Accession:
    P47755
    Secondary Accessions:
    • B4DG50

    Protein attributes for CAPZA2 Gene

    Size:
    286 amino acids
    Molecular mass:
    32949 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP.

    Alternative splice isoforms for CAPZA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPZA2 Gene

Post-translational modifications for CAPZA2 Gene

  • Ubiquitination at posLast=1919, posLast=133133, and posLast=226226
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CAPZA2 Gene

Domains & Families for CAPZA2 Gene

Protein Domains for CAPZA2 Gene

Graphical View of Domain Structure for InterPro Entry

P47755

UniProtKB/Swiss-Prot:

CAZA2_HUMAN :
  • Belongs to the F-actin-capping protein alpha subunit family.
Family:
  • Belongs to the F-actin-capping protein alpha subunit family.
genes like me logo Genes that share domains with CAPZA2: view

No data available for Gene Families for CAPZA2 Gene

Function for CAPZA2 Gene

Molecular function for CAPZA2 Gene

GENATLAS Biochemistry:
actin-capping protein Z,alpha 2 subunit,amplified in the glioblastoma
UniProtKB/Swiss-Prot Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Gene Ontology (GO) - Molecular Function for CAPZA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CAPZA2: view

Phenotypes for CAPZA2 Gene

genes like me logo Genes that share phenotypes with CAPZA2: view

Animal Models for CAPZA2 Gene

MGI Knock Outs for CAPZA2:

Animal Model Products

CRISPR Products

miRNA for CAPZA2 Gene

miRTarBase miRNAs that target CAPZA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPZA2 Gene

Localization for CAPZA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPZA2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for CAPZA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005903 brush border IEA --
GO:0008290 F-actin capping protein complex IEA --
GO:0015629 actin cytoskeleton TAS 9331217
genes like me logo Genes that share ontologies with CAPZA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPZA2 Gene

Pathways & Interactions for CAPZA2 Gene

genes like me logo Genes that share pathways with CAPZA2: view

Pathways by source for CAPZA2 Gene

Gene Ontology (GO) - Biological Process for CAPZA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9331217
GO:0006928 movement of cell or subcellular component TAS 9331217
GO:0007596 blood coagulation TAS --
GO:0045087 innate immune response TAS --
GO:0051016 barbed-end actin filament capping IEA --
genes like me logo Genes that share ontologies with CAPZA2: view

No data available for SIGNOR curated interactions for CAPZA2 Gene

Drugs & Compounds for CAPZA2 Gene

(1) Drugs for CAPZA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CAPZA2: view

Transcripts for CAPZA2 Gene

Unigene Clusters for CAPZA2 Gene

Capping protein (actin filament) muscle Z-line, alpha 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: -
SP6: - -

Relevant External Links for CAPZA2 Gene

GeneLoc Exon Structure for
CAPZA2
ECgene alternative splicing isoforms for
CAPZA2

Expression for CAPZA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPZA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPZA2 Gene



Protein tissue co-expression partners for CAPZA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPZA2 Gene:

CAPZA2

SOURCE GeneReport for Unigene cluster for CAPZA2 Gene:

Hs.446123

Evidence on tissue expression from TISSUES for CAPZA2 Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Liver(4.4)
  • Blood(4.3)
  • Eye(4.2)
  • Pancreas(4.2)
  • Intestine(3.4)
  • Lung(3)
  • Heart(2.3)
  • Spleen(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CAPZA2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPZA2 Gene

Orthologs for CAPZA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAPZA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPZA2 34 35
  • 99.65 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPZA2 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPZA2 34 35
  • 95.92 (n)
cow
(Bos Taurus)
Mammalia CAPZA2 34 35
  • 95.1 (n)
mouse
(Mus musculus)
Mammalia Capza2 34 16 35
  • 93.82 (n)
rat
(Rattus norvegicus)
Mammalia Capza2 34
  • 93.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CAPZA2 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPZA2 34 35
  • 89.98 (n)
lizard
(Anolis carolinensis)
Reptilia CAPZA2 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capza2 34
  • 83.22 (n)
Str.10827 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21413 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11052 34
fruit fly
(Drosophila melanogaster)
Insecta CG10540 36
  • 61 (a)
cpa 35
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cap-1 36 35
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP1 34 35 37
  • 46.35 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13453g 34
  • 45.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR007C 34
  • 44.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8055 35
  • 52 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03911 34
  • 45.57 (n)
Species where no ortholog for CAPZA2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CAPZA2 Gene

ENSEMBL:
Gene Tree for CAPZA2 (if available)
TreeFam:
Gene Tree for CAPZA2 (if available)

Paralogs for CAPZA2 Gene

Paralogs for CAPZA2 Gene

(2) SIMAP similar genes for CAPZA2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CAPZA2 Gene

genes like me logo Genes that share paralogs with CAPZA2: view

Variants for CAPZA2 Gene

Sequence variations from dbSNP and Humsavar for CAPZA2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000062727 -- 116,867,651(+) CGATC(-/TCGGCTCACTGCA)ACCTC intron-variant
rs1000098302 -- 116,918,625(+) CAAAT(C/T)GTAAT nc-transcript-variant, utr-variant-3-prime
rs1000118673 -- 116,886,682(+) TTTCC(A/C)AGGAC intron-variant
rs1000152473 -- 116,868,627(+) TACTC(A/G)GGAGG intron-variant
rs1000253332 -- 116,900,804(+) AGAAC(C/T)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPZA2 Gene

Variant ID Type Subtype PubMed ID
dgv1324e214 CNV gain 21293372
esv3576422 CNV gain 25503493
esv3891196 CNV gain 25118596
nsv7405 OTHER inversion 18451855
nsv831107 CNV gain 17160897

Variation tolerance for CAPZA2 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPZA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPZA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPZA2 Gene

Disorders for CAPZA2 Gene

Relevant External Links for CAPZA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPZA2

No disorders were found for CAPZA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPZA2 Gene

Publications for CAPZA2 Gene

  1. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PMID: 7665558) Barron-Casella E.A. … Casella J.F. (J. Biol. Chem. 1995) 3 4 22 64
  2. The phosphorylation of CapZ-interacting protein (CapZIP) by stress- activated protein kinases triggers its dissociation from CapZ. (PMID: 15850461) Eyers C.E. … Cohen P. (Biochem. J. 2005) 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for CAPZA2 Gene

Sources for CAPZA2 Gene

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