Aliases for CAPZA2 Gene
External Ids for CAPZA2 Gene
Previous GeneCards Identifiers for CAPZA2 Gene
The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAPZA2 Gene
CAPZA2 (Capping Actin Protein Of Muscle Z-Line Alpha Subunit 2) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Advanced glycosylation endproduct receptor signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.
UniProtKB/Swiss-Prot for CAPZA2 Gene
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.