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Aliases for CAPZA1 Gene

Aliases for CAPZA1 Gene

  • Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1 2 3
  • Capping Protein (Actin Filament) Muscle Z-Line, Alpha 1 2 3 5
  • CapZ Alpha-1 3 4
  • CAPPA1 3
  • Cap Z 3
  • CAPZ 3
  • CAZ1 3

External Ids for CAPZA1 Gene

Previous GeneCards Identifiers for CAPZA1 Gene

  • GC01P113584
  • GC01P112047
  • GC01P112263
  • GC01P112461
  • GC01P112873
  • GC01P112963
  • GC01P113161
  • GC01P111020

Summaries for CAPZA1 Gene

Entrez Gene Summary for CAPZA1 Gene

  • CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPZA1 Gene

CAPZA1 (Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include actin binding. An important paralog of this gene is CAPZA3.

UniProtKB/Swiss-Prot for CAPZA1 Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Gene Wiki entry for CAPZA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPZA1 Gene

Genomics for CAPZA1 Gene

Regulatory Elements for CAPZA1 Gene

Promoters for CAPZA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAPZA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPZA1 Gene

Chromosome:
1
Start:
112,619,173 bp from pter
End:
112,671,619 bp from pter
Size:
52,447 bases
Orientation:
Plus strand

Genomic View for CAPZA1 Gene

Genes around CAPZA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPZA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPZA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZA1 Gene

Proteins for CAPZA1 Gene

  • Protein details for CAPZA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52907-CAZA1_HUMAN
    Recommended name:
    F-actin-capping protein subunit alpha-1
    Protein Accession:
    P52907
    Secondary Accessions:
    • Q53FQ6
    • Q6FHD5

    Protein attributes for CAPZA1 Gene

    Size:
    286 amino acids
    Molecular mass:
    32923 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with S100A (By similarity). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts with S100B.

    Three dimensional structures from OCA and Proteopedia for CAPZA1 Gene

neXtProt entry for CAPZA1 Gene

Proteomics data for CAPZA1 Gene at MOPED

Post-translational modifications for CAPZA1 Gene

  • Ubiquitination at Lys 97, Lys 118, Lys 133, Lys 166, Lys 178, and Lys 226
  • Modification sites at PhosphoSitePlus

Other Protein References for CAPZA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CAPZA1 Gene

Domains & Families for CAPZA1 Gene

Protein Domains for CAPZA1 Gene

Suggested Antigen Peptide Sequences for CAPZA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52907

UniProtKB/Swiss-Prot:

CAZA1_HUMAN :
  • Belongs to the F-actin-capping protein alpha subunit family.
Family:
  • Belongs to the F-actin-capping protein alpha subunit family.
genes like me logo Genes that share domains with CAPZA1: view

No data available for Gene Families for CAPZA1 Gene

Function for CAPZA1 Gene

Molecular function for CAPZA1 Gene

UniProtKB/Swiss-Prot Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Gene Ontology (GO) - Molecular Function for CAPZA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CAPZA1: view

Phenotypes for CAPZA1 Gene

GenomeRNAi human phenotypes for CAPZA1:
genes like me logo Genes that share phenotypes with CAPZA1: view

Animal Model Products

miRNA for CAPZA1 Gene

miRTarBase miRNAs that target CAPZA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPZA1 Gene

Localization for CAPZA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPZA1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPZA1 Gene COMPARTMENTS Subcellular localization image for CAPZA1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CAPZA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008290 F-actin capping protein complex IEA --
GO:0070062 extracellular exosome IDA 19056867
GO:0071203 WASH complex IDA 19922875
genes like me logo Genes that share ontologies with CAPZA1: view

Pathways & Interactions for CAPZA1 Gene

genes like me logo Genes that share pathways with CAPZA1: view

SIGNOR curated interactions for CAPZA1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CAPZA1 Gene

None

Drugs & Compounds for CAPZA1 Gene

No Compound Related Data Available

Transcripts for CAPZA1 Gene

Unigene Clusters for CAPZA1 Gene

Capping protein (actin filament) muscle Z-line, alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for CAPZA1 Gene

GeneLoc Exon Structure for
CAPZA1
ECgene alternative splicing isoforms for
CAPZA1

Expression for CAPZA1 Gene

mRNA expression in normal human tissues for CAPZA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPZA1 Gene

This gene is overexpressed in Whole Blood (x6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPZA1 Gene



SOURCE GeneReport for Unigene cluster for CAPZA1 Gene Hs.744974

genes like me logo Genes that share expression patterns with CAPZA1: view

Protein tissue co-expression partners for CAPZA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAPZA1 Gene

Orthologs for CAPZA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAPZA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAPZA1 35
  • 95.92 (n)
  • 98.6 (a)
CAPZA1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPZA1 35
  • 96.62 (n)
  • 97.2 (a)
-- 36
  • 94 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Capza1 35
  • 92.42 (n)
  • 96.5 (a)
Capza1 16
4933400A11Rik 36
  • 68 (a)
OneToMany
Capza1 36
  • 96 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CAPZA1 35
  • 97.2 (n)
  • 96.5 (a)
CAPZA1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capza1 35
  • 93.12 (n)
  • 97.2 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPZA1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
chicken
(Gallus gallus)
Aves CAPZA1 35
  • 84.62 (n)
  • 92.31 (a)
CAPZA1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPZA1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capza1 35
  • 78.55 (n)
  • 88.46 (a)
zebrafish
(Danio rerio)
Actinopterygii capza1a 35
  • 75.99 (n)
  • 81.47 (a)
wufa19e05 35
fruit fly
(Drosophila melanogaster)
Insecta CG10540 37
  • 64 (a)
cpa 35
  • 61.13 (n)
  • 64.98 (a)
cpa 36
  • 62 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006141 35
  • 59.74 (n)
  • 64.79 (a)
worm
(Caenorhabditis elegans)
Secernentea cap-1 37
  • 55 (a)
cap-1 35
  • 57.51 (n)
  • 57.51 (a)
cap-1 36
  • 54 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP1 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05520 35
  • 47.52 (n)
  • 31.21 (a)
rice
(Oryza sativa)
Liliopsida Os07g0414800 35
  • 49.06 (n)
  • 34.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2607 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8055 36
  • 55 (a)
OneToMany
Species with no ortholog for CAPZA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPZA1 Gene

ENSEMBL:
Gene Tree for CAPZA1 (if available)
TreeFam:
Gene Tree for CAPZA1 (if available)

Paralogs for CAPZA1 Gene

Paralogs for CAPZA1 Gene

(2) SIMAP similar genes for CAPZA1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CAPZA1: view

Variants for CAPZA1 Gene

Sequence variations from dbSNP and Humsavar for CAPZA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_073834 -
rs1238 -- 112,671,475(-) GTCAC(C/T)TGGAA utr-variant-3-prime
rs1060163 -- 112,670,051(+) CGCCG(C/G)CAGCT reference, synonymous-codon
rs1060168 -- 112,670,626(+) TCTCC(C/T)TCTGA utr-variant-3-prime
rs1060171 -- 112,670,816(+) CATTG(G/T)CTCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CAPZA1 Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV Gain+Loss 19812545
essv21692 CNV CNV 17122850
nsv159055 CNV Loss 16902084
esv274511 CNV Insertion 20981092

Variation tolerance for CAPZA1 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPZA1 Gene

HapMap Linkage Disequilibrium report
CAPZA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPZA1 Gene

Disorders for CAPZA1 Gene

Relevant External Links for CAPZA1

Genetic Association Database (GAD)
CAPZA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPZA1

No disorders were found for CAPZA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPZA1 Gene

Publications for CAPZA1 Gene

  1. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N. … He J. (Nat. Genet. 2011) 3 48 67
  2. Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. (PMID: 12690097) Hutchings N.J. … Brown M.H. (J. Biol. Chem. 2003) 3 23
  3. Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes. (PMID: 9119363) Hart M.C. … Cooper J.A. (Genomics 1997) 2 3
  4. Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes. (PMID: 8639502) Maun N.A. … Southwick F.S. (Biochemistry 1996) 3 23
  5. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PMID: 7665558) Barron-Casella E.A. … Casella J.F. (J. Biol. Chem. 1995) 2 3

Products for CAPZA1 Gene

Sources for CAPZA1 Gene

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