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CAPZA1 Gene

protein-coding   GIFtS: 58
GCID: GC01P113161

Capping Protein (Actin Filament) Muscle Z-Line, Alpha 1

  Search for CAPZA1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Capping Protein (Actin Filament) Muscle Z-Line, Alpha 11 2     CAZ12
CapZ Alpha-12 3     Cap Z2
CAPPA12 5     F-Actin-Capping Protein Subunit Alpha-12
CAPZ2     

External Ids:    HGNC: 14881   Entrez Gene: 8292   Ensembl: ENSG000001164897   OMIM: 6015805   UniProtKB: P529073   

Export aliases for CAPZA1 gene to outside databases

Previous GC identifers: GC01P113584 GC01P112047 GC01P112263 GC01P112461 GC01P112873 GC01P112963 GC01P111020


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAPZA1 Gene:
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the
barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of
growing actin filaments. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAPZA1 Gene:
CAPZA1 (capping protein (actin filament) muscle Z-line, alpha 1) is a protein-coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is CAPZA2.

UniProtKB/Swiss-Prot: CAZA1_HUMAN, P52907
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
(barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as
gelsolin and severin), these proteins do not sever actin filaments

Gene Wiki entry for CAPZA1 (Capping protein muscle Z-line, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CAPZA1 gene promoter:
         GR   Pax-5   AML1a   GATA-3   GR-beta   STAT5A   POU6F1 (c2)   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CAPZA1 promoter sequence
   Search Chromatin IP Primers for CAPZA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPZA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

CAPZA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPZA1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P113161:  view genomic region     (about GC identifiers)

Start:
113,161,795 bp from pter      End:
113,214,241 bp from pter
Size:
52,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAZA1_HUMAN, P52907 (See protein sequence)
Recommended Name: F-actin-capping protein subunit alpha-1  
Size: 286 amino acids; 32923 Da
Subunit: Heterodimer of an alpha and a beta subunit. Interacts with S100A (By similarity). Component of the WASH
complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein
subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C),
KIAA1033, KIAA0196 and CCDC53. Interacts with S100B
2 PDB 3D structures from and Proteopedia for CAPZA1:
1MQ1 (3D)        1MWN (3D)    
Secondary accessions: Q53FQ6 Q6FHD5

Explore the universe of human proteins at neXtProt for CAPZA1: NX_P52907

Explore proteomics data for CAPZA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19, Lys97, Lys118, Lys133, Lys166, Lys178, Lys226, Lys273, Lys278, Lys281
  • Modification sites at PhosphoSitePlus

  • See CAPZA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006126.1  
    ENSEMBL proteins: 
     ENSP00000263168  
    Reactome Protein details: P52907

    CAPZA1 Human Recombinant Protein Products:

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    Novus Biologicals CAPZA1 Proteins
    Novus Biologicals CAPZA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CAPZA1 

    CAPZA1 Antibody Products:

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    CAPZA1 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CAPZA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017865 F-actin_cap_asu_CS
     IPR002189 CapZ_alpha

    Graphical View of Domain Structure for InterPro Entry P52907

    ProtoNet protein and cluster: P52907

    1 Blocks protein domain: IPB002189 F-actin capping protein

    UniProtKB/Swiss-Prot: CAZA1_HUMAN, P52907
    Similarity: Belongs to the F-actin-capping protein alpha subunit family


    Find genes that share domains with CAPZA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAZA1_HUMAN, P52907
    Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
    (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as
    gelsolin and severin), these proteins do not sever actin filaments

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CAPZA1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPZA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAPZA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPZA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPZA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAPZA1:
    hsa-mir-9-5p (MIRT021466), hsa-mir-7-5p (MIRT004060), hsa-mir-140-3p (MIRT021670), hsa-mir-30c-5p (MIRT047861)

    Block miRNA regulation of human, mouse, rat CAPZA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPZA1 (see all 10):
    hsa-miR-30c hsa-miR-548p hsa-miR-30d hsa-miR-421 hsa-miR-659 hsa-miR-9 hsa-miR-30a hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidCAPZA1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CAPZA1
    Predesigned siRNA for gene silencing in human, mouse, rat CAPZA1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CAPZA1 (NM_006135)
    Sino Biological Human cDNA Clone for CAPZA1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPZA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAZA1_HUMAN, P52907: Cytoplasm, cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    extracellular4
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169
    GO:0008290F-actin capping protein complex IEA--
    GO:0015629actin cytoskeleton TAS7665558

    Find genes that share ontologies with CAPZA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAPZA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    2Hemostasis
    Hemostasis0.43
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production
    4Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation
    5Advanced glycosylation endproduct receptor signaling
    Advanced glycosylation endproduct receptor signaling


    Find genes that share SuperPaths with CAPZA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CAPZA1
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments


    2 Reactome Pathways for CAPZA1
        Advanced glycosylation endproduct receptor signaling
    Factors involved in megakaryocyte development and platelet production


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAPZA1
    Interactions:

        GeneGlobe Interaction Network for CAPZA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAPZA1 (P529071, 2, 3 ENSP000002631684) via UniProtKB, MINT, STRING, and/or I2D (see all 979)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    UCHL5Q9Y5K52, 3, ENSP000003564254MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000356425
    SMARCB1Q128242, 3MINT-7945693 MINT-7947479 I2D: score=4 
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    IKBKGQ9Y6K92, 3MINT-48138 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9331217
    GO:0006928cellular component movement TAS16130169
    GO:0007596blood coagulation TAS--
    GO:0030036actin cytoskeleton organization IEA--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with CAPZA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAPZA1 (CAZA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAPZA1 gene: 
    NM_006135.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263168(uc001ecj.1) ENST00000485542 ENST00000476936 ENST00000498626
    ENST00000466066 ENST00000476820
    miRNA
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    Block miRNA regulation of human, mouse, rat CAPZA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPZA1 (see all 10):
    hsa-miR-30c hsa-miR-548p hsa-miR-30d hsa-miR-421 hsa-miR-659 hsa-miR-9 hsa-miR-30a hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidCAPZA1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CAPZA1
    Predesigned siRNA for gene silencing in human, mouse, rat CAPZA1
    Clone
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    OriGene clones in human, mouse for CAPZA1 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAPZA1 (NM_006135)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPZA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA1
    Primer
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    OriGene qPCR primer pairs and template standards for CAPZA1
    OriGene qSTAR qPCR primer pairs in human, mouse for CAPZA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CAPZA1
      QuantiTect SYBR Green Assays in human, mouse, rat CAPZA1
      QuantiFast Probe-based Assays in human, mouse, rat CAPZA1

    Selected AceView cDNA sequences (see all 528):

    AA626587 BM459032 CB155794 T24982 W58012 AU100344 AA133542 BM479075 
    W92769 AU280349 AA609497 CA394302 BQ439857 AI034038 BM835386 AA825424 
    R77687 AW206207 AA974488 BQ435121 CK570343 BC000144 AA227468 BM829322 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                    -                 -                       -           -                           
    SP2:                                      -                       -                                       
    SP3:                    -                                                                                 
    SP4:                                                                          -                           
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CAPZA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAPZA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAAAAAAG
    CAPZA1 Expression
    About this image


    CAPZA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Lung (Respiratory System)
    CAPZA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPZA1 Protein Expression
        Custom PCR Arrays for CAPZA1
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat CAPZA1
    QuantiFast Probe-based Assays in human, mouse, rat CAPZA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPZA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAPZA1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capza11 , 5 capping protein (actin filament) muscle Z-line, alpha more1, 5 92.42(n)1
    96.5(a)1
      3 (45.88 cM)5
    123401  NM_009797.21  NP_033927.21 
     1048227795 
    chicken
    (Gallus gallus)
    Aves CAPZA11 capping protein (actin filament) muscle Z-line, alpha more 84.62(n)
    92.31(a)
      396521  NM_205515.1  NP_990846.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAPZA16
    capping protein (actin filament) muscle Z-line, al...
    90(a)
    1 ↔ 1
    4(128165831-128190426)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041745.12   -- 79.48(n)    BC041745.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa19e052 Danio rerio similar to F-actin capping protein alpha-1 more 79.25(n)    BC047860.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105403
    cpa1
    actin cytoskeleton organization and
    biogenesis more3
    capping protein alpha1
    64(a)3
    61.13(n)1
    64.98(a)1
      57B163
    373871  NM_137695.31  NP_611539.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cap-11 , 3 cap-11 55(a)3
    57.51(n)1
    57.51(a)1
      IV(7228891-7230410)3
    1774971  NM_068744.31  NP_501145.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAP16
    Alpha subunit of the capping protein (CP) heterodi...
    28(a)
    1 → many
    XI(429302-430108) YKL007W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G055201 AT3G05520 47.52(n)
    31.21(a)
      819717  NM_001161121.1  NP_001154593.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04148001 Os07g0414800 49.06(n)
    34.87(a)
      4343018  NM_001065993.1  NP_001059458.1 


    ENSEMBL Gene Tree for CAPZA1 (if available)
    TreeFam Gene Tree for CAPZA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAPZA1 gene
    CAPZA22  CAPZA32  
    2 SIMAP similar genes for CAPZA1 using alignment to 1 protein entry:     CAZA1_HUMAN:
    CAPZA2    CAPZA3

    Find genes that share paralogs with CAPZA1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CAPZA1 (see all 6)
    PGOHUM00000240403 PGOHUM00000232998 PGOHUM00000233057 PGOHUM00000233573 PGOHUM00000241386


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAPZA1 (see all 921)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139067931,2
    F--111060568(+) AGTTTCT/-CTCTC 1 -- int13Minor allele frequency- -:0.50CSA 6
    rs1403953121,2
    --113164127(+) TCTTCA/GCCACT 1 -- int10--------
    rs1470256601,2
    C--113164191(+) ATAATG/TTAAAT 1 -- int10--------
    rs1833072481,2
    --113164235(+) ACACAC/TTGACC 1 -- int10--------
    rs353736261,2
    C--113164383(+) TATGG-/TTTTTT 1 -- int10--------
    rs1383118031,2
    --113164454(+) TCTCCG/TCTCGC 1 -- int10--------
    rs1438996521,2
    --113164771(+) GTTTTA/TTATCT 1 -- int10--------
    rs1143216761,2
    F--113164999(+) TTTTAG/TAAATA 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1127095481,2
    F--113165666(+) CCACAC/TCCGGC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1419370491,2
    C--113165699(+) AGACA-/GGGTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CAPZA1 (113161795 - 113214241 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CAPZA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274511CNV Insertion20981092
    nsv159055CNV Loss16902084
    esv27061CNV Gain+Loss19812545
    essv21692CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAPZA1
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPZA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601580    OMIM disorders: --


    Find genes that share disorders with CAPZA1           About GenesLikeMe

    Genetic Association Database (GAD): CAPZA1

    Export disorders for CAPZA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAPZA1 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with CAPZA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PubMed id 21572416)1, 4 Kato N....He J. (Nat. Genet. 2011)
    2. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PubMed id 19922875)1, 2 Derivery E.... Gautreau A. (Dev. Cell 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex. (PubMed id 12480931)1, 2 McClintock K.A. and Shaw G.S. (J. Biol. Chem. 2003)
    6. Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12. (PubMed id 12470955)1, 2 Inman K.G....Weber D.J. (J. Mol. Biol. 2002)
    7. Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes. (PubMed id 9119363)1, 3 Hart M.C....Cooper J.A. (Genomics 1997)
    8. Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. (PubMed id 9331217)1, 2 Hart M.C.... Cooper J.A. (Cell Motil. Cytoskeleton 1997)
    9. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PubMed id 7665558)1, 3 Barron-Casella E.A.... Casella J.F. (J. Biol. Chem. 1995)
    10. Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. (PubMed id 12690097)1, 9 Hutchings N.J.... Brown M.H. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 829 HGNC: 1488 AceView: CAPZA1 Ensembl:ENSG00000116489 euGenes: HUgn829
    ECgene: CAPZA1 H-InvDB: CAPZA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CAPZA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAPZA1 gene:
    Search GeneIP for patents involving CAPZA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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