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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPZA1 Gene

protein-coding   GIFtS: 61
GCID: GC01P113161

capping protein (actin filament) muscle Z-line, alpha 1
 Explore 11 diseases affiliated with
CAPZA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CAPZA1    

Aliases
for CAPZA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Capping Protein (Actin Filament) Muscle Z-Line, Alpha 11 2     CAZ12
CapZ Alpha-12 3     Cap Z2
CAPPA12 5     F-Actin-Capping Protein Subunit Alpha-12
CAPZ2     

External Ids:    HGNC: 14881   Entrez Gene: 8292   Ensembl: ENSG000001164897   OMIM: 6015805   UniProtKB: P529073   

Export aliases for CAPZA1 gene to outside databases

Previous GC identifers: GC01P113584 GC01P112047 GC01P112263 GC01P112461 GC01P112873 GC01P112963 GC01P111020


Summaries
for CAPZA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CAPZA1:
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the
barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of
growing actin filaments. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAZA1_HUMAN, P52907
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
(barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin
and severin), these proteins do not sever actin filaments

Gene Wiki entry for CAPZA1 (Capping protein muscle Z-line, alpha 1)


Genomic Views
for CAPZA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPZA1 gene promoter:
         GR   Pax-5   AML1a   GATA-3   GR-beta   STAT5A   POU6F1 (c2)   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CAPZA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPZA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPZA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

CAPZA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPZA1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P113161:  view genomic region     (about GC identifiers)

Start:
 113,161,795 bp from pter      End:
 113,214,241 bp from pter
Size:
 52,447 bases      Orientation:
 plus strand

Proteins
for CAPZA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CAZA1_HUMAN, P52907 (See protein sequence)
Recommended Name: F-actin-capping protein subunit alpha-1  
Size: 286 amino acids; 32923 Da
Subunit: Heterodimer of an alpha and a beta subunit. Interacts with S100A (By similarity). Component of the WASH
complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit
beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033,
KIAA0196 and CCDC53. Interacts with S100B
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
2 PDB 3D structures from and Proteopedia for CAPZA1:
1MQ1 (3D)        1MWN (3D)    
Secondary accessions: Q53FQ6 Q6FHD5

Explore the universe of human proteins at neXtProt for CAPZA1: NX_P52907

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52907

    • CAPZA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006126.1  
    ENSEMBL proteins: 
     ENSP00000263168  
    Reactome Protein details: P52907
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: CAPZA1
    OriGene Protein Over-expression Lysate: CAPZA1
    OriGene Custom Protein Services for CAPZA1 
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    Novus Biologicals CAPZA1 Proteins
    Novus Biologicals CAPZA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169
    GO:0008290F-actin capping protein complex IEA--
    GO:0015629actin cytoskeleton TAS7665558


    CAPZA1 for ontologies           About GeneDecksing



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    Assay Products for CAPZA1: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CAPZA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CAPZA1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR017865 F-actin_cap_asu_CS
     IPR002189 WASH_F-actin_cap_alpha

    Graphical View of Domain Structure for InterPro Entry P52907

    ProtoNet protein and cluster: P52907

    1 Blocks protein family: IPB002189 F-actin capping protein

    UniProtKB/Swiss-Prot: CAZA1_HUMAN, P52907
    Similarity: Belongs to the F-actin-capping protein alpha subunit family


    Function
    for CAPZA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CAZA1_HUMAN, P52907
    Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments
    (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin
    and severin), these proteins do not sever actin filaments

    miRNA
    Products:            		miRTarBase miRNAs that target CAPZA1:
    hsa-mir-7 (MIRT004060)

    OriGene 3'-UTR Clone: CAPZA1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPZA1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPZA1 (see all 10):
    hsa-miR-30c hsa-miR-548p hsa-miR-30d hsa-miR-421 hsa-miR-659 hsa-miR-9 hsa-miR-30a hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmid: CAPZA1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPZA1 (see all 7)
    OriGene shRNA RFP: CAPZA1
    OriGene siRNA: CAPZA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPZA1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CAPZA1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPZA1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPZA1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CAPZA1 (NM_006135)
    Sino Biological Human cDNA Clone for CAPZA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPZA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CAPZA1
    Search LifeMap BioReagents cell lines for CAPZA1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPZA1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--


    CAPZA1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CAPZA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Neurofilaments
    		Cytoskeleton remodeling Neurofilaments1.00
    		Cytoplasmic microtubules0.32
    		Cytoskeleton remodeling_Neurofilaments0.91
    2Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    3Immune System
    		Immune System1.00
    		Innate Immune System0.46
    4Factors involved in megakaryocyte development and platelet production
    		Factors involved in megakaryocyte development and platelet production1.00
    5Advanced glycosylation endproduct receptor signaling
    		Advanced glycosylation endproduct receptor signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for CAPZA1
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for CAPZA1
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments

    5        Reactome Pathways for CAPZA1
        Hemostasis
    Advanced glycosylation endproduct receptor signaling
    Factors involved in megakaryocyte development and platelet production
    Immune System
    Innate Immune System



    CAPZA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAPZA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/815 Interacting proteins for CAPZA1 (P529072, 3 ENSP000002631684) via UniProtKB, MINT, STRING, and/or I2D (see all 815)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    UCHL5Q9Y5K52, 3, ENSP000003564254MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000356425
    SMARCB1Q128242, 3MINT-7945693 MINT-7947479 I2D: score=4 
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    IKBKGQ9Y6K92, 3MINT-48138 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9331217
    GO:0006928cellular component movement TAS16130169
    GO:0007596blood coagulation TAS--
    GO:0030036actin cytoskeleton organization IEA--
    GO:0045087innate immune response TAS--


    CAPZA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CAPZA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAPZA1
    Search CenterWatch for drugs/clinical trials and news about CAPZA1 / CAZA1 

    Transcripts
    for CAPZA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CAPZA1 gene: 
    NM_006135.2  

    Unigene Cluster for CAPZA1:

    Capping protein (actin filament) muscle Z-line, alpha 1
    Hs.514934  [show with all ESTs]
    Unigene Representative Sequence: BX648738
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263168(uc001ecj.1) ENST00000485542 ENST00000476936 ENST00000498626
    ENST00000466066 ENST00000476820

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPZA1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPZA1 (see all 10):
    hsa-miR-30c hsa-miR-548p hsa-miR-30d hsa-miR-421 hsa-miR-659 hsa-miR-9 hsa-miR-30a hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmid: CAPZA1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPZA1 (see all 7)
    OriGene shRNA RFP: CAPZA1
    OriGene siRNA: CAPZA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPZA1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPZA1 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CAPZA1 (NM_006135)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPZA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPZA1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPZA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CAPZA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPZA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPZA1

    Additional cDNA sequence: 

    AJ227918.1 AK223226.1 AK289654.1 BC000144.1 BC034391.1 BT019364.1 BX648738.1 CR407657.1 
    CR541819.1 U56637.1 

    24/33 DOTS entries (see all 33):

    DT.449300  DT.100798732  DT.92451572  DT.100776461  DT.100801803  DT.100733900  DT.100878614  DT.101985168 
    DT.100878610  DT.121335962  DT.95254343  DT.100798735  DT.121335914  DT.95185767  DT.100878612  DT.75187904 
    DT.95361379  DT.121335959  DT.95254316  DT.100762562  DT.100878616  DT.121335972  DT.121336041  DT.92451573 

    24/528 AceView cDNA sequences (see all 528):

    AA825424 AA974488 BQ433753 CD642748 CF143623 BQ223148 AA227468 AA343967 
    AI041368 BU187939 AA195145 BG112372 BU754232 BU902261 BQ435121 AA626599 
    CA310510 AA747710 AI279013 CR407657 BX421531 CR541819 AL518230 AA280618 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                    -                 -                       -           -                           
    SP2:                                      -                       -                                       
    SP3:                    -                                                                                 
    SP4:                                                                          -                           
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CAPZA1

    Expression
    for CAPZA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPZA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAAAAAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CAPZA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePelvic MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePosterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CAPZA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPZA1

    SOURCE GeneReport for Unigene cluster: Hs.514934
        SABiosciences Custom PCR Arrays for CAPZA1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPZA1

    Orthologs
    for CAPZA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAPZA1 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CAPZA11 capping protein (actin filament) muscle Z-line, alpha more 84.62(n)
    92.31(a)    		   396521  NM_205515.1  NP_990846.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CAPZA16
    		 --
    		 90(a)
    		 1 ↔ 1
    		 4(128165923-128188308)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC041745.12   -- 79.48(n)    BC041745.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa19e052 Danio rerio similar to F-actin capping protein alpha-1 more 79.25(n)    BC047860.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG105403
    cpa1    		 actin cytoskeleton organization and
    biogenesis more3
    capping protein alpha1    		 64(a)3
    61.01(n)1
    64.98(a)1    		   57B163
    373871  NM_137695.31  NP_611539.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea cap-11 , 3 Protein CAP-11 55(a)3
    57.51(n)1
    57.51(a)1    		   IV(7228891-7230410)3
    1774971  NM_068744.21  NP_501145.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G055201 F-actin-capping protein subunit alpha 47.89(n)
    30.99(a)    		   819717  NM_111425.5  NP_187203.1 
    rice
    (Oryza sativa)    		 Liliopsida Os07g04148001 hypothetical protein 49.06(n)
    34.87(a)    		   4343018  NM_001065993.1  NP_001059458.1 


    ENSEMBL Gene Tree for CAPZA1 (if available)
    TreeFam Gene Tree for CAPZA1 (if available) 

    Paralogs
    for CAPZA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAPZA1 gene
    CAPZA22  CAPZA32  
    2 SIMAP similar genes for CAPZA1 using alignment to 1 protein entry:     CAZA1_HUMAN:
    CAPZA2    CAPZA3

    CAPZA1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for CAPZA1 (see all 6)
    PGOHUM00000240403 PGOHUM00000232998 PGOHUM00000233057 PGOHUM00000233573 PGOHUM00000241386


    Genomic Variants
    for CAPZA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/825 NCBI SNPs in CAPZA1 are shown (see all 825)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs111025131,2
    		C,F,A,H,--113160170(+) CTCTAC/TGCAAA 5 -- int1 us2k112Minor allele frequency- T:0.24NS EA NA WA 788
    rs716776461,2
    		C--113160331(+) CTCTC-/TCACACA 5 -- us2k1 int10--------
    rs1400161071,2
    		--113160331(+) GTCTT-/TCTC  
                TCTCT     		5 -- us2k1 int10--------
    rs49931281,2
    		C,F,--113160339(+) CTCTCT/ACACAC 5 -- int1 us2k1 trp32Minor allele frequency- A:0.50NA CSA 4
    rs568550531,2
    		C--113160341(+) CACAC-/ACGAAAC 5 -- int1 us2k12Minor allele frequency- AC:0.25NA 4
    rs568641921,2
    		C,F,--113160341(+) CTCTCT/ACACAC 5 -- int1 us2k15Minor allele frequency- A:0.50NA CSA 12
    rs49931271,2
    		C,H--113160349(+) CTcacA/Tcacac 5 -- us2k1 int11Minor allele frequency- T:0.00NA 2
    rs1874779241,2
    		--113160378(+) ACACAA/CGAAAC 5 -- int1 us2k10--------
    rs1161335381,2
    		F,--113160409(+) GTAATC/TAACTA 5 -- int1 us2k11Minor allele frequency- T:0.02WA 118
    rs111025141,2
    		C,F,A,H,--113160419(+) ATTCTC/TATCTA 5 -- us2k1 int113Minor allele frequency- T:0.24NS EA NA WA 786

    HapMap Linkage Disequilibrium report for CAPZA1 (113161795 - 113214241 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CAPZA1
         2 CNVs: 3306 64617
         1 Indel: 11416

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    Disorders / Diseases
    for CAPZA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CAPZA1 for disorders           About GeneDecksing

    OMIM gene information: 601580    OMIM disorders: --

    11 diseases for CAPZA1:    About MalaCards
    oral squamous cell carcinoma    squamous cell carcinoma    rheumatoid arthritis    down syndrome
    endocarditis    hepatocellular carcinoma    arthritis    carcinoma
    melanoma    malaria    neuronitis


    Export disorders for CAPZA1 gene to outside databases

    Publications
    for CAPZA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPZA1 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with CAPZA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PubMed id 19922875)1, 2 Derivery E.... Gautreau A. (2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex. (PubMed id 12480931)1, 2 McClintock K.A. and Shaw G.S. (2003)
    5. Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12. (PubMed id 12470955)1, 2 Inman K.G....Weber D.J. (2002)
    6. Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes. (PubMed id 9119363)1, 3 Hart M.C....Cooper J.A. (1997)
    7. Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. (PubMed id 9331217)1, 2 Hart M.C.... Cooper J.A. (1997)
    8. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PubMed id 7665558)1, 3 Barron-Casella E.A.... Casella J.F. (1995)
    9. Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. (PubMed id 12690097)1, 9 Hutchings N.J.... Brown M.H. (2003)
    10. Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes. (PubMed id 8639502)1, 9 Maun N.A....Southwick F.S. (1996)

    External Searches for CAPZA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CAPZA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 829 HGNC: 1488 AceView: CAPZA1 Ensembl:ENSG00000116489 euGenes: HUgn829
    ECgene: CAPZA1 H-InvDB: CAPZA1

    Other Databases showing CAPZA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CAPZA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPZA1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CAPZA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CAPZA1 gene:
    Search GeneIP for patents involving CAPZA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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