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Aliases for CAPSL Gene

Aliases for CAPSL Gene

  • Calcyphosine Like 2 3 5
  • Calcyphosine-Like 2

External Ids for CAPSL Gene

Previous GeneCards Identifiers for CAPSL Gene

  • GC05M035941
  • GC05M035854

Summaries for CAPSL Gene

GeneCards Summary for CAPSL Gene

CAPSL (Calcyphosine Like) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CAPS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPSL Gene

Genomics for CAPSL Gene

Regulatory Elements for CAPSL Gene

Enhancers for CAPSL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F035777 1.2 Ensembl ENCODE 10.9 +161.0 160979 0.4 ZFP64 RAD21 ZNF121 ZNF143 ZNF202 ZNF362 ZNF680 SP3 ZNF654 ZBTB11 BRIX1 LOC105374724 CAPSL LOC100506406 RNU7-130P
GH05F035779 1.2 Ensembl ENCODE 10.9 +158.0 157985 2.8 PKNOX1 NR2F2 LOC105374724 LOC100506406 CAPSL SPEF2 RNU7-130P
GH05F035908 1.4 Ensembl ENCODE 10.4 +29.9 29868 1.0 CAPSL LOC100506406 ENSG00000248349
GH05F035879 0.6 ENCODE 10.2 +59.5 59466 0.2 IL7R LOC105374724 CAPSL LOC100506406 ENSG00000279737
GH05F035876 0.6 ENCODE 10.2 +61.7 61686 0.2 MXI1 STAT1 JUN CEBPB MAX USF2 EBF1 EP300 RFX5 JUND IL7R LOC105374724 CAPSL LOC100506406 ENSG00000279737
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CAPSL on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPSL Gene

35,904,295 bp from pter
35,938,779 bp from pter
34,485 bases
Minus strand

Genomic View for CAPSL Gene

Genes around CAPSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPSL Gene

Proteins for CAPSL Gene

  • Protein details for CAPSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcyphosin-like protein
    Protein Accession:

    Protein attributes for CAPSL Gene

    208 amino acids
    Molecular mass:
    24229 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH17586.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CAPSL Gene

Post-translational modifications for CAPSL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPSL Gene

No data available for DME Specific Peptides for CAPSL Gene

Domains & Families for CAPSL Gene

Gene Families for CAPSL Gene

Protein Domains for CAPSL Gene

Suggested Antigen Peptide Sequences for CAPSL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 EF-hand domains.
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with CAPSL: view

Function for CAPSL Gene

Gene Ontology (GO) - Molecular Function for CAPSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CAPSL: view
genes like me logo Genes that share phenotypes with CAPSL: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAPSL Gene

Localization for CAPSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPSL Gene


Subcellular locations from

Jensen Localization Image for CAPSL Gene COMPARTMENTS Subcellular localization image for CAPSL gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAPSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CAPSL: view

Pathways & Interactions for CAPSL Gene

SuperPathways for CAPSL Gene

No Data Available

Interacting Proteins for CAPSL Gene

Gene Ontology (GO) - Biological Process for CAPSL Gene


No data available for Pathways by source and SIGNOR curated interactions for CAPSL Gene

Transcripts for CAPSL Gene

Unigene Clusters for CAPSL Gene

Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPSL Gene

No ASD Table

Relevant External Links for CAPSL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPSL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPSL Gene

This gene is overexpressed in Pituitary (x9.2), Fallopian Tube (x7.6), Testis (x6.8), and Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for CAPSL Gene

This gene is overexpressed in Nasal epithelium (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAPSL Gene

Protein tissue co-expression partners for CAPSL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPSL Gene:


SOURCE GeneReport for Unigene cluster for CAPSL Gene:

genes like me logo Genes that share expression patterns with CAPSL: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CAPSL Gene

Orthologs for CAPSL Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPSL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAPSL 34 35
  • 99.2 (n)
(Canis familiaris)
Mammalia CAPSL 35
  • 96 (a)
(Monodelphis domestica)
Mammalia CAPSL 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia CAPSL 35
  • 91 (a)
(Bos Taurus)
Mammalia CAPSL 34 35
  • 90.54 (n)
(Mus musculus)
Mammalia Capsl 34 16 35
  • 89.42 (n)
(Rattus norvegicus)
Mammalia Capsl 34
  • 89.26 (n)
(Gallus gallus)
Aves CAPSL 34 35
  • 79.49 (n)
(Anolis carolinensis)
Reptilia CAPSL 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia capsl 34
  • 74.75 (n)
Str.19315 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.18844 34
(Danio rerio)
Actinopterygii capslb 34 35
  • 71.63 (n)
wufj05b10 34
fruit fly
(Drosophila melanogaster)
Insecta CG10126 34 35
  • 56.29 (n)
CG31345 35
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007666 34
  • 55.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1998 34
Species where no ortholog for CAPSL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPSL Gene

Gene Tree for CAPSL (if available)
Gene Tree for CAPSL (if available)

Paralogs for CAPSL Gene

Paralogs for CAPSL Gene

(6) SIMAP similar genes for CAPSL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAPSL: view

Variants for CAPSL Gene

Sequence variations from dbSNP and Humsavar for CAPSL Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10042510 -- 35,921,411(+) GAAGT(C/G)CAATT intron-variant
rs10053411 -- 35,914,951(+) aattg(A/G)tagaa intron-variant
rs10054418 -- 35,924,207(+) CCACA(C/T)GCTGT intron-variant
rs10064755 -- 35,913,502(+) acagc(G/T)gatct intron-variant
rs10074186 -- 35,928,758(+) cacaa(G/T)atggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPSL Gene

Variant ID Type Subtype PubMed ID
esv3604707 CNV gain 21293372
nsv471011 CNV gain 18288195
nsv4794 CNV deletion 18451855
nsv483069 CNV gain 15286789
nsv830261 CNV gain 17160897

Variation tolerance for CAPSL Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPSL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPSL Gene

Disorders for CAPSL Gene

Relevant External Links for CAPSL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CAPSL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPSL Gene

Publications for CAPSL Gene

  1. Study of the association between the CAPSL-IL7R locus and type 1 diabetes. (PMID: 18563381) Santiago J.L. … Urcelay E. (Diabetologia 2008) 3 46 64
  2. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PMID: 17554260) Todd J.A. … Clayton D.G. (Nat. Genet. 2007) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for CAPSL Gene

Sources for CAPSL Gene

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