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Aliases for CAPSL Gene

Aliases for CAPSL Gene

  • Calcyphosine-Like 2 3

External Ids for CAPSL Gene

Previous GeneCards Identifiers for CAPSL Gene

  • GC05M035941
  • GC05M035854

Summaries for CAPSL Gene

GeneCards Summary for CAPSL Gene

CAPSL (Calcyphosine-Like) is a Protein Coding gene. Diseases associated with CAPSL include primary biliary cirrhosis. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CAPS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPSL Gene

Genomics for CAPSL Gene

Regulatory Elements for CAPSL Gene

Genomic Location for CAPSL Gene

Start:
35,904,295 bp from pter
End:
35,938,779 bp from pter
Size:
34,485 bases
Orientation:
Minus strand

Genomic View for CAPSL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPSL Gene

Proteins for CAPSL Gene

  • Protein details for CAPSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWF8-CAPSL_HUMAN
    Recommended name:
    Calcyphosin-like protein
    Protein Accession:
    Q8WWF8
    Secondary Accessions:

    Protein attributes for CAPSL Gene

    Size:
    208 amino acids
    Molecular mass:
    24229 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17586.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CAPSL Gene

Proteomics data for CAPSL Gene at MOPED

Post-translational modifications for CAPSL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPSL Gene

No data available for DME Specific Peptides for CAPSL Gene

Domains for CAPSL Gene

Gene Families for CAPSL Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CAPSL Gene

Suggested Antigen Peptide Sequences for CAPSL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWF8

UniProtKB/Swiss-Prot:

CAPSL_HUMAN :
  • Q8WWF8
Domain:
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with CAPSL: view

Function for CAPSL Gene

Gene Ontology (GO) - Molecular Function for CAPSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CAPSL: view

Phenotypes for CAPSL Gene

MGI mutant phenotypes for CAPSL:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with CAPSL: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPSL

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CAPSL Gene

Localization for CAPSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPSL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPSL Gene COMPARTMENTS Subcellular localization image for CAPSL gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAPSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CAPSL: view

Pathways for CAPSL Gene

SuperPathways for CAPSL Gene

No Data Available

Interacting Proteins for CAPSL Gene

Gene Ontology (GO) - Biological Process for CAPSL Gene

None

No data available for Pathways by source for CAPSL Gene

Transcripts for CAPSL Gene

Unigene Clusters for CAPSL Gene

Calcyphosine-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPSL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPSL Gene

No ASD Table

Relevant External Links for CAPSL Gene

GeneLoc Exon Structure for
CAPSL
ECgene alternative splicing isoforms for
CAPSL

Expression for CAPSL Gene

mRNA expression in normal human tissues for CAPSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPSL Gene

This gene is overexpressed in Pituitary (9.2), Fallopian Tube (7.6), Testis (6.8), and Brain - Hypothalamus (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAPSL Gene

SOURCE GeneReport for Unigene cluster for CAPSL Gene Hs.55150

genes like me logo Genes that share expressions with CAPSL: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CAPSL Gene

Orthologs for CAPSL Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPSL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPSL 35
  • 99.2 (n)
  • 99.04 (a)
CAPSL 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPSL 35
  • 90.54 (n)
  • 96.15 (a)
CAPSL 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPSL 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capsl 35
  • 89.42 (n)
  • 94.71 (a)
Capsl 16
Capsl 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPSL 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPSL 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capsl 35
  • 89.26 (n)
  • 94.23 (a)
chicken
(Gallus gallus)
Aves CAPSL 35
  • 79.49 (n)
  • 83.17 (a)
CAPSL 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPSL 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18844 35
tropical clawed frog
(Silurana tropicalis)
Amphibia capsl 35
  • 74.75 (n)
  • 80.81 (a)
Str.19315 35
zebrafish
(Danio rerio)
Actinopterygii capslb 35
  • 71.63 (n)
  • 75.96 (a)
capslb 36
  • 64 (a)
OneToOne
wufj05b10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007666 35
  • 55.93 (n)
  • 52.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10126 35
  • 56.29 (n)
  • 52.55 (a)
CG10126 36
  • 44 (a)
ManyToMany
CG31345 36
  • 46 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1998 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
ManyToMany
Species with no ortholog for CAPSL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPSL Gene

ENSEMBL:
Gene Tree for CAPSL (if available)
TreeFam:
Gene Tree for CAPSL (if available)

Paralogs for CAPSL Gene

Paralogs for CAPSL Gene

Selected SIMAP similar genes for CAPSL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAPSL: view

Variants for CAPSL Gene

Sequence variations from dbSNP and Humsavar for CAPSL Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs696732 -- 35,935,928(-) CTGCC(A/G)TTAAG intron-variant
rs696733 -- 35,932,437(-) CTTGC(C/T)TTTTG intron-variant
rs696734 -- 35,928,406(-) CAGAG(A/T)CTTCA intron-variant
rs700170 -- 35,935,536(-) gcaac(A/G)tagca intron-variant
rs700171 -- 35,934,559(-) CCTCT(A/C/T)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPSL Gene

Variant ID Type Subtype PubMed ID
nsv483069 CNV Gain 15286789
nsv471011 CNV Gain 18288195
nsv830261 CNV Gain 17160897
nsv4794 CNV Loss 18451855

Relevant External Links for CAPSL Gene

HapMap Linkage Disequilibrium report
CAPSL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPSL Gene

Disorders for CAPSL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CAPSL Gene including...

Search for CAPSL Gene in MalaCards »

Relevant External Links for CAPSL

Genetic Association Database (GAD)
CAPSL
Human Genome Epidemiology (HuGE) Navigator
CAPSL
genes like me logo Genes that share disorders with CAPSL: view

No data available for UniProtKB/Swiss-Prot for CAPSL Gene

Publications for CAPSL Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PMID: 17554260) Todd J.A. … Clayton D.G. (Nat. Genet. 2007) 3 48
  4. Study of the association between the CAPSL-IL7R locus and type 1 diabetes. (PMID: 18563381) Santiago J.L. … Urcelay E. (Diabetologia 2008) 3 48
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CAPSL Gene

Sources for CAPSL Gene

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