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Aliases for CAPS2 Gene

Aliases for CAPS2 Gene

  • Calcyphosine 2 2 3
  • Calcyphosphine 2 2 3
  • Calcyphosine-2 4
  • Calcyphosin-2 3
  • UG0636c06 3

External Ids for CAPS2 Gene

Previous GeneCards Identifiers for CAPS2 Gene

  • GC12P073945
  • GC12M075580
  • GC12M075386
  • GC12M073956
  • GC12M075669
  • GC12M072719

Summaries for CAPS2 Gene

Entrez Gene Summary for CAPS2 Gene

  • Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 [PubMed 11846421]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CAPS2 Gene

CAPS2 (Calcyphosine 2) is a Protein Coding gene. Diseases associated with CAPS2 include alexithymia. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CAPS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPS2 Gene

Genomics for CAPS2 Gene

Regulatory Elements for CAPS2 Gene

Genomic Location for CAPS2 Gene

75,275,979 bp from pter
75,390,928 bp from pter
114,950 bases
Minus strand

Genomic View for CAPS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPS2 Gene

Proteins for CAPS2 Gene

  • Protein details for CAPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6PH84
    • Q8N242
    • Q8NAY5

    Protein attributes for CAPS2 Gene

    557 amino acids
    Molecular mass:
    63835 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAN76511.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03845.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CAPS2 Gene


neXtProt entry for CAPS2 Gene

Proteomics data for CAPS2 Gene at MOPED

Post-translational modifications for CAPS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAPS2 Gene

Domains for CAPS2 Gene

Gene Families for CAPS2 Gene

Protein Domains for CAPS2 Gene


Suggested Antigen Peptide Sequences for CAPS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EF-hand domains.
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with CAPS2: view

Function for CAPS2 Gene

Gene Ontology (GO) - Molecular Function for CAPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CAPS2: view

Phenotypes for CAPS2 Gene

GenomeRNAi human phenotypes for CAPS2:
genes like me logo Genes that share phenotypes with CAPS2: view

Animal Model Products

miRNA for CAPS2 Gene

miRTarBase miRNAs that target CAPS2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPS2 Gene

Localization for CAPS2 Gene

Subcellular locations from

Jensen Localization Image for CAPS2 Gene COMPARTMENTS Subcellular localization image for CAPS2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CAPS2 Gene

Pathways for CAPS2 Gene

SuperPathways for CAPS2 Gene

No Data Available

Interacting Proteins for CAPS2 Gene

Gene Ontology (GO) - Biological Process for CAPS2 Gene


No data available for Pathways by source for CAPS2 Gene

Transcripts for CAPS2 Gene

Unigene Clusters for CAPS2 Gene

Calcyphosine 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for CAPS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPS2 Gene

mRNA expression in normal human tissues for CAPS2 Gene

Protein differential expression in normal tissues for CAPS2 Gene

This gene is overexpressed in Monocytes (38.4), CD8 Tcells (12.7), and Bone (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAPS2 Gene

SOURCE GeneReport for Unigene cluster for CAPS2 Gene Hs.733835

mRNA Expression by UniProt/SwissProt for CAPS2 Gene

Tissue specificity: Abundantly expressed in many tissues. Expressed in brain, colon, heart, kidney, liver, lung, liver, pancreas, placenta, skeletal muscle, testis and thymus. Highest expression in colon, testis, lung, placenta and brain.
genes like me logo Genes that share expressions with CAPS2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for CAPS2 Gene

Orthologs for CAPS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAPS2 35
  • 86.16 (n)
  • 77.63 (a)
CAPS2 36
  • 66 (a)
(Canis familiaris)
Mammalia CAPS2 35
  • 83.92 (n)
  • 74.67 (a)
CAPS2 36
  • 67 (a)
(Mus musculus)
Mammalia Caps2 35
  • 77.21 (n)
  • 69.7 (a)
Caps2 16
Caps2 36
  • 61 (a)
(Pan troglodytes)
Mammalia CAPS2 35
  • 98.98 (n)
  • 98.03 (a)
CAPS2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Caps2 35
  • 80.68 (n)
  • 74.34 (a)
(Monodelphis domestica)
Mammalia CAPS2 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia CAPS2 36
  • 60 (a)
(Gallus gallus)
Aves CAPS2 35
  • 65.97 (n)
  • 58.44 (a)
CAPS2 36
  • 53 (a)
(Anolis carolinensis)
Reptilia CAPS2 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia caps2 35
  • 64.17 (n)
  • 56.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14895 35
(Danio rerio)
Actinopterygii LOC101884719 35
  • 49.25 (n)
  • 38.29 (a)
caps2 36
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10126 36
  • 15 (a)
CG31345 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10452 36
  • 26 (a)
Species with no ortholog for CAPS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPS2 Gene

Gene Tree for CAPS2 (if available)
Gene Tree for CAPS2 (if available)

Paralogs for CAPS2 Gene

Paralogs for CAPS2 Gene

(2) SIMAP similar genes for CAPS2 Gene using alignment to 8 proteins: Pseudogenes for CAPS2 Gene

genes like me logo Genes that share paralogs with CAPS2: view

Variants for CAPS2 Gene

Sequence variations from dbSNP and Humsavar for CAPS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3923914 -- 75,378,200(-) GCAAC(A/G)TGGCA intron-variant
rs3923915 -- 75,377,893(-) cagat(A/T)tttta intron-variant
rs3923916 -- 75,377,886(-) tttat(A/T)tatat intron-variant
rs3924594 -- 75,289,016(+) GTATG(C/T)GAAGA intron-variant
rs4131731 -- 75,303,859(-) tctgg(C/T)actct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPS2 Gene

Variant ID Type Subtype PubMed ID
dgv98n21 CNV Gain 19592680
nsv899309 CNV Gain 21882294
nsv899310 CNV Loss 21882294
nsv899311 CNV Loss 21882294
nsv899312 CNV Loss 21882294
nsv899313 CNV Gain 21882294

Relevant External Links for CAPS2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPS2 Gene

Disorders for CAPS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CAPS2 Gene in MalaCards »

(1) Disease for CAPS2 Gene

(2) University of Copenhagen DISEASES for CAPS2 Gene

genes like me logo Genes that share disorders with CAPS2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for CAPS2 Gene

Publications for CAPS2 Gene

  1. Cloning, characterization, and expression of calcyphosine 2, a novel human gene encoding an EF-hand Ca(2+)-binding protein. (PMID: 11846421) Wang S. … Mao Y. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  5. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski M.K. … Reilly M.P. (BMC Med. Genet. 2013) 3

Products for CAPS2 Gene

Sources for CAPS2 Gene

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