CAPS2 Gene
protein-coding GIFtS: 46
GCID: GC12M075669
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calcyphosine 2(Previous name: calcyphosphine 2 )
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Aliases
for CAPS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcyphosine 21 2 | | Calcyphosphine 21 2 | | Calcyphosin-21 | | Calcyphosine-23 | | Calcyphosine-23 |
Export aliases for CAPS2 gene to outside databasesPrevious GC identifers: GC12P073945 GC12M075580 GC12M075386 GC12M073956 GC12M072719 |
Summaries
for CAPS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CAPS2:
Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 (PubMed 11846421)).(supplied byOMIM, Mar 2008)
|
Genomic Views
for CAPS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CAPS2 gene promoter:
SRF SRY Sox5 Ik-2 SRF (504 AA) STAT3 CUTL1 ZID Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAPS2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPS2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q14.1 Ensembl cytogenetic band: 12q21.2 HGNC cytogenetic band: 12q14.1CAPS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M075669: view genomic region
(about GC identifiers)
Start:
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75,669,759 bp from pter |
End:
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75,784,708 bp from pter |
Size:
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114,950 bases |
Orientation:
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minus strand |
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Proteins
for CAPS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAYP2_HUMAN, Q9BXY5 (See
protein sequence)Recommended Name: Calcyphosin-2 Size: 557 amino acids; 63835 Da
Sequence caution: Sequence=AAN76511.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAC03845.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6PH84 Q8N242 Q8NAY5Alternative splicing: 3 isoforms: Q9BXY5-1 Q9BXY5-2 Q9BXY5-3 Explore the universe of human proteins at neXtProt for CAPS2: NX_Q9BXY5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXY5
CAPS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115995.2
ENSEMBL proteins: ENSP00000386977 ENSP00000386959 ENSP00000376963 ENSP00000331007 ENSP00000338474 ENSP00000449797 ENSP00000447737 ENSP00000411797 ENSP00000389633
Human Recombinant Protein Products:
CAPS2 Antibody Products:
Assay Products for CAPS2: |
Protein
Domains /
Families
for CAPS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAPS2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXY5ProtoNet protein and cluster: Q9BXY5 UniProtKB/Swiss-Prot: CAYP2_HUMAN, Q9BXY5Similarity: Contains 3 EF-hand domains |
Function
for CAPS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CAPS2 (NM_032606) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAPS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPS2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPS2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
CAPS2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CAPS2:
|
Pathways & Interactions
for CAPS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAPS2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CAPS2 (ENSP000003869594) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for CAPS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CAPS2
Search CenterWatch for drugs/clinical trials and news about CAPS2 / CAYP2
|
Transcripts
for CAPS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CAPS2 gene: NM_032606.3 Unigene Cluster for CAPS2: Calcyphosine 2 Hs.733835 [show with all ESTs]Unigene Representative Sequence: AF25105615 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409004(uc001sxi.4) ENST00000409799(uc001sxj.4) ENST00000409445(uc001sxk.4)
ENST00000393284(uc001sxl.3) ENST00000328705(uc001sxm.3 uc009zsa.2)
ENST00000336815 ENST00000552497 ENST00000551829 ENST00000436898 ENST00000486196
ENST00000493070 ENST00000548958 ENST00000547320 ENST00000548035 ENST00000442339
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CAPS2 (NM_032606) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAPS2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPS2 |
Additional cDNA sequence: AF251056.1 AF351611.1 AK091839.1 AK092274.1 BC033860.1 BC056672.1 BC131724.1 7 DOTS entries: DT.40243396 DT.97819612 DT.100019219 DT.95322641 DT.99961623 DT.40286266 DT.121199050 24/31 AceView cDNA sequences (see all 31): AF351611 AI683837 AK091839 AX747212 AX747446 BU854839 NM_032606 BC033860 AK092274 AF251056 AW818339 AW591332 BG120629 W15505 BQ574079 BU959280 CA414246 AA876648 BX499794 BI830999 BC056672 BU569101 BU678679 W39726
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CAPS2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
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| SP1: | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | - | | | | | | | | - | | - | | | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CAPS2
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Expression
for CAPS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CAPS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGAGGCT
About this image
See CAPS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAPS2
SOURCE GeneReport for Unigene cluster: Hs.733835
UniProtKB/Swiss-Prot: CAYP2_HUMAN, Q9BXY5Tissue specificity: Abundantly expressed in many tissues. Expressed in brain, colon, heart, kidney, liver, lung, liver,pancreas, placenta, skeletal muscle, testis and thymus. Highest expression in colon, testis, lung, placenta and brain
SABiosciences Custom PCR Arrays for CAPS2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAPS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPS2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPS2 |
Orthologs
for CAPS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CAPS2 gene from 5/20 species (see all 20) About this table
ENSEMBL Gene Tree for CAPS2 (if available)
TreeFam Gene Tree for CAPS2 (if available) |
Paralogs
for CAPS2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CAPS2 gene
- CAPSL2 CAPS2
2 SIMAP similar genes for CAPS2 using alignment to 8 protein entries: CAYP2_HUMAN (see all proteins):CAPS CAPSL
CAPS2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CAPS2
PGOHUM00000246102
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Genomic Variants
for CAPS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CAPS2 (75669759 - 75784708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CAPS2
2 CNVs: 86467 86466 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAPS2 |
|
Disorders
/ Diseases
for CAPS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CAPS2 for disorders About MalaCards
CAPS2 for disorders About GeneDecksing
OMIM gene information: 607724
OMIM disorders: --
2 diseases from the University of Copenhagen DISEASES database for CAPS2:Alexithymia Autistic disorder Export disorders for CAPS2 gene to outside databases
|
Publications
for CAPS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CAPS2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CAPS2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, characterization, and expression of calcyphosine 2, a novel human gene encoding an EF-hand Ca(2+)-binding protein. (PubMed id 11846421)1, 2, 3 Wang S....Mao Y. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. (PubMed id 14530279)1 Speidel D.... Reim K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Rheumatoid wrist deformities and their relation to ulnar drift. (PubMed id 1184642)1 Hastings D.E. and Evans J.A. (1975)
|
External Searches for CAPS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CAPS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CAPS2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CAPS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CAPS2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CAPS2 gene:
Search GeneIP for patents involving CAPS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAPS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPS2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPS2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CAPS2 | | OriGene 3'-UTR Clone for CAPS2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CAPS2 | | OriGene Custom Protein Services for CAPS2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAPS2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAPS2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPS2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPS2 |
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| | | | Search Tocris compounds for CAPS2 |
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 | | | CAPS2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPS2 |
|  |  |  | | | | ThermoFisher Antibodies for CAPS2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPS2 |
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