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Aliases for CAPS Gene

Aliases for CAPS Gene

  • Calcyphosine 2 3 4 5
  • Thyroid Protein P24 2 3
  • Calcyphosine 1 2 3
  • Calcyphosin 3
  • CAPS1 3

External Ids for CAPS Gene

Previous GeneCards Identifiers for CAPS Gene

  • GC19P006006
  • GC19P005851
  • GC19P005865
  • GC19P005673

Summaries for CAPS Gene

Entrez Gene Summary for CAPS Gene

  • This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPS Gene

CAPS (Calcyphosine) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CAPSL.

UniProtKB/Swiss-Prot for CAPS Gene

  • Calcium-binding protein. May play a role in cellular signaling events (Potential).

Gene Wiki entry for CAPS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPS Gene

Genomics for CAPS Gene

Regulatory Elements for CAPS Gene

Enhancers for CAPS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G005956 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.1 +51.5 51546 13.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 SIN3A ARID4B DMAP1 FEZF1 VMAC CAPS NDUFA11 FUT5 ACSBG2 ENSG00000267571 GPR108 FUT3 FUT6 SLC25A41
GH19G005908 1.2 ENCODE dbSUPER 33.2 -1.7 -1655 2.8 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 PAF1 SP5 MXD4 ZHX2 CAPS NDUFA11 ENSG00000267314 VMAC
GH19G005902 1.2 ENCODE 32.2 -7.5 -7546 3.6 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 CAPS ENSG00000269680 VMAC NDUFA11 ENSG00000267314
GH19G005945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +39.4 39351 10.3 FOXA2 PKNOX1 MLX SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF766 ZNF143 NDUFA11 CAPS FUT5 VMAC ACSBG2 FUT3 FUT6 SAFB2 GC19P005968 ENSG00000267571
GH19G005913 1.3 Ensembl ENCODE dbSUPER 19.8 +3.6 3612 3.3 KLF1 AGO1 ZMYM3 KLF17 ZIC2 RAD21 GLIS2 POLR2A SCRT2 MAFK CAPS FUT3 FUT6 CATSPERD ENSG00000267571 GC19P005968
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAPS on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPS Gene

Chromosome:
19
Start:
5,911,707 bp from pter
End:
5,916,211 bp from pter
Size:
4,505 bases
Orientation:
Plus strand

Genomic View for CAPS Gene

Genes around CAPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPS Gene

Proteins for CAPS Gene

  • Protein details for CAPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13938-CAYP1_HUMAN
    Recommended name:
    Calcyphosin
    Protein Accession:
    Q13938
    Secondary Accessions:
    • Q3MJA7
    • Q8WUZ3

    Protein attributes for CAPS Gene

    Size:
    189 amino acids
    Molecular mass:
    20967 Da
    Quaternary structure:
    • Monomer. Does not form oligomers in the presence of calcium.

    Three dimensional structures from OCA and Proteopedia for CAPS Gene

    Alternative splice isoforms for CAPS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPS Gene

Post-translational modifications for CAPS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPS Gene

No data available for DME Specific Peptides for CAPS Gene

Domains & Families for CAPS Gene

Gene Families for CAPS Gene

Protein Domains for CAPS Gene

Suggested Antigen Peptide Sequences for CAPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CAPS: view

No data available for UniProtKB/Swiss-Prot for CAPS Gene

Function for CAPS Gene

Molecular function for CAPS Gene

GENATLAS Biochemistry:
calcyphosine,calcium binding protein
UniProtKB/Swiss-Prot Function:
Calcium-binding protein. May play a role in cellular signaling events (Potential).

Gene Ontology (GO) - Molecular Function for CAPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
genes like me logo Genes that share ontologies with CAPS: view
genes like me logo Genes that share phenotypes with CAPS: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAPS Gene

Localization for CAPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPS gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CAPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0031982 vesicle IDA 19190083
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CAPS: view

Pathways & Interactions for CAPS Gene

No Data Available

Interacting Proteins for CAPS Gene

Selected Interacting proteins: Q13938-CAYP1_HUMAN for CAPS Gene via IID

Symbol External ID(s) Details
TUBB2B

Gene Ontology (GO) - Biological Process for CAPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction TAS 2540953
genes like me logo Genes that share ontologies with CAPS: view

No data available for Pathways by source and SIGNOR curated interactions for CAPS Gene

Drugs & Compounds for CAPS Gene

(19) Drugs for CAPS Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 228
Substance P Investigational Pharma Full agonist, Agonist 249
Antibodies Pharma 6394
Antibodies, Antiphospholipid Pharma 29
Antibodies, Monoclonal Pharma 4039
genes like me logo Genes that share compounds with CAPS: view

Transcripts for CAPS Gene

Unigene Clusters for CAPS Gene

Calcyphosine:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for CAPS Gene

GeneLoc Exon Structure for
CAPS
ECgene alternative splicing isoforms for
CAPS

Expression for CAPS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPS Gene

mRNA differential expression in normal tissues according to GTEx for CAPS Gene

This gene is overexpressed in Cervix - Endocervix (x4.2).

Protein differential expression in normal tissues from HIPED for CAPS Gene

This gene is overexpressed in Nasal epithelium (39.4), Spinal cord (8.8), and Cervix (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPS Gene



NURSA nuclear receptor signaling pathways regulating expression of CAPS Gene:

CAPS

SOURCE GeneReport for Unigene cluster for CAPS Gene:

Hs.584744

Evidence on tissue expression from TISSUES for CAPS Gene

  • Thyroid gland(4.4)
  • Skin(4.2)
  • Nervous system(4.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with CAPS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPS Gene

Orthologs for CAPS Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPS 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia CAPS 34 35
  • 88.36 (n)
cow
(Bos Taurus)
Mammalia CAPS 34 35
  • 84.48 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPS 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPS 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii capsla 35
  • 55 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10126 36 35
  • 47 (a)
CG31345 35
  • 41 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
Species where no ortholog for CAPS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPS Gene

ENSEMBL:
Gene Tree for CAPS (if available)
TreeFam:
Gene Tree for CAPS (if available)

Paralogs for CAPS Gene

Paralogs for CAPS Gene

(5) SIMAP similar genes for CAPS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAPS: view

Variants for CAPS Gene

Sequence variations from dbSNP and Humsavar for CAPS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000127676 -- 5,914,032(+) CCCCT(G/T)CAGGG utr-variant-5-prime
rs1001065514 -- 5,912,459(+) GCACC(C/T)GGCTG upstream-variant-2KB
rs1001380062 -- 5,915,783(+) CAGAA(A/G)CTGAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1001704498 -- 5,915,805(+) GAAAA(A/G)AAAAT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1002892498 -- 5,915,963(+) AGGGG(G/T)GGGGG intron-variant, downstream-variant-500B, utr-variant-3-prime

Variation tolerance for CAPS Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CAPS Gene

Disorders for CAPS Gene

Relevant External Links for CAPS

Genetic Association Database (GAD)
CAPS
Human Genome Epidemiology (HuGE) Navigator
CAPS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPS

No disorders were found for CAPS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPS Gene

Publications for CAPS Gene

  1. Cloning and sequence analysis of human calcyphosine complementary DNA. (PMID: 9224948) el Housni H. … Christophe D. (Biochim. Biophys. Acta 1997) 2 3 4 22 64
  2. Localization of human calcyphosine gene (CAPS) to the p13.3 region of chromosome 19 by in situ hybridization. (PMID: 2265558) Lefort A. … Mattei M.G. (Cytogenet. Cell Genet. 1990) 2 3 22 64
  3. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  4. Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family. (PMID: 18775726) Dong H. … Rao Z. (J. Mol. Biol. 2008) 3 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64

Products for CAPS Gene

Sources for CAPS Gene

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