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CAPS Gene(Protein Coding)

Calcyphosine

GCID:
GC19P005911
GIFtS:
51
Genes Participants
UDN Logo

Aliases for CAPS Gene

Aliases for CAPS Gene

  • Calcyphosine 2 3 4 5
  • Thyroid Protein P24 2 3
  • Calcyphosine 1 2 3
  • Calcyphosin 3
  • CAPS1 3

External Ids for CAPS Gene

Previous GeneCards Identifiers for CAPS Gene

  • GC19P006006
  • GC19P005851
  • GC19P005865
  • GC19P005673

Summaries for CAPS Gene

Entrez Gene Summary for CAPS Gene

  • This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPS Gene

CAPS (Calcyphosine) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CAPSL.

UniProtKB/Swiss-Prot for CAPS Gene

  • Calcium-binding protein. May play a role in cellular signaling events (Potential).

Gene Wiki entry for CAPS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPS Gene

Genomics for CAPS Gene

Products:

  1. Regulatory Element

Regulatory Elements for CAPS Gene

Enhancers for CAPS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F005956 1.6 FANTOM5 Ensembl ENCODE 27.1 +51.5 51546 13.9 PKNOX1 ARNT MLX ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 VMAC CAPS NDUFA11 FUT5 ACSBG2 ENSG00000267571 MIR6791 FUT3 FUT6 SLC25A41
GH19F005902 1.2 ENCODE 32.2 -7.5 -7546 3.6 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 CAPS SNRPEP4 ENSG00000269680 ENSG00000267314 NDUFA11 VMAC
GH19F005908 1 ENCODE 33.2 -1.7 -1655 2.8 MLX ZFP64 ARID4B DMAP1 ZNF48 PAF1 SP5 ZHX2 MXD4 PPARG CAPS NDUFA11 ENSG00000267314 VMAC
GH19F005892 1.2 Ensembl ENCODE 27.2 -19.2 -19207 0.6 ATF1 ARID4B ZNF2 ZNF263 PAF1 SP5 MXD4 REST PPARG KAT8 CAPS NDUFA11 GC19P005889 ENSG00000266941
GH19F005945 1.6 FANTOM5 Ensembl ENCODE 19.4 +39.4 39351 10.3 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 SP5 NDUFA11 CAPS FUT5 VMAC ACSBG2 FUT3 FUT6 SAFB2 GC19P005968 ENSG00000267571
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAPS on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CAPS gene promoter:

Genomic Location for CAPS Gene

Chromosome:
19
Start:
5,911,707 bp from pter
End:
5,916,211 bp from pter
Size:
4,505 bases
Orientation:
Plus strand

Genomic View for CAPS Gene

Genes around CAPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CAPS Gene

Proteins for CAPS Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CAPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13938-CAYP1_HUMAN
    Recommended name:
    Calcyphosin
    Protein Accession:
    Q13938
    Secondary Accessions:
    • Q3MJA7
    • Q8WUZ3

    Protein attributes for CAPS Gene

    Size:
    189 amino acids
    Molecular mass:
    20967 Da
    Quaternary structure:
    • Monomer. Does not form oligomers in the presence of calcium.

    Three dimensional structures from OCA and Proteopedia for CAPS Gene

    Alternative splice isoforms for CAPS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPS Gene

Protein Expression for CAPS Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CAPS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CAPS

No data available for DME Specific Peptides for CAPS Gene

Domains & Families for CAPS Gene

Gene Families for CAPS Gene

HGNC:

Protein Domains for CAPS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13938

UniProtKB/Swiss-Prot:

CAYP1_HUMAN :
  • Contains 4 EF-hand domains.
Domain:
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with CAPS: view

Function for CAPS Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CAPS Gene

GENATLAS Biochemistry:
calcyphosine,calcium binding protein
UniProtKB/Swiss-Prot Function:
Calcium-binding protein. May play a role in cellular signaling events (Potential).

Gene Ontology (GO) - Molecular Function for CAPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CAPS: view
genes like me logo Genes that share phenotypes with CAPS: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAPS Gene

Localization for CAPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPS gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CAPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0031982 vesicle IDA 19190083
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CAPS: view

Pathways & Interactions for CAPS Gene

SuperPathways for CAPS Gene

PathCards logo More details on SuperPathways for CAPS
No Data Available

Interacting Proteins for CAPS Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000222125%0d%0a9606.ENSP00000377384%0d%0a9606.ENSP00000416040%0d%0a9606.ENSP00000265335%0d%0a9606.ENSP00000336606%0d%0a9606.ENSP00000361043%0d%0a
Selected Interacting proteins: ENSP00000222125 Q13938-CAYP1_HUMAN for CAPS Gene via STRING IID

Gene Ontology (GO) - Biological Process for CAPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction TAS 2540953
genes like me logo Genes that share ontologies with CAPS: view

No data available for Pathways by source and SIGNOR curated interactions for CAPS Gene

Drugs & Compounds for CAPS Gene

Products:

  1. Drug

(19) Drugs for CAPS Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 226
Substance P Investigational Pharma Full agonist, Agonist 245
Antibodies Pharma 6045
Antibodies, Antiphospholipid Pharma 29
Antibodies, Monoclonal Pharma 3795
genes like me logo Genes that share compounds with CAPS: view

Transcripts for CAPS Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CAPS Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(186) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAPS Gene

Calcyphosine:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for CAPS Gene

GeneLoc Exon Structure for
CAPS
ECgene alternative splicing isoforms for
CAPS

Expression for CAPS Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPS Gene

mRNA expression in normal human tissues for CAPS Gene
mRNA expression by BioGPS for CAPS GenemRNA expression by GTEx for CAPS Gene

mRNA differential expression in normal tissues according to GTEx for CAPS Gene

This gene is overexpressed in Cervix - Endocervix (x4.2).

Protein differential expression in normal tissues from HIPED for CAPS Gene

This gene is overexpressed in Nasal epithelium (39.4), Spinal cord (8.8), and Cervix (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPS Gene



NURSA nuclear receptor signaling pathways regulating expression of CAPS Gene:

CAPS

SOURCE GeneReport for Unigene cluster for CAPS Gene:

Hs.584744
genes like me logo Genes that share expression patterns with CAPS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CAPS Gene

Orthologs for CAPS Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CAPS 34 35
  • 99.65 (n)
dog
(Canis familiaris)
 Mammalia CAPS 34 35
  • 88.36 (n)
cow
(Bos Taurus)
 Mammalia CAPS 34 35
  • 84.48 (n)
oppossum
(Monodelphis domestica)
 Mammalia CAPS 35
  • 75 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CAPS 35
  • 72 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii capsla 35
  • 55 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG10126 36 35
  • 47 (a)
CG31345 35
  • 41 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 47 (a)
 ManyToMany
-- 35
  • 20 (a)
 ManyToMany
Species where no ortholog for CAPS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPS Gene

ENSEMBL:
Gene Tree for CAPS (if available)
TreeFam:
Gene Tree for CAPS (if available)

Paralogs for CAPS Gene

Paralogs for CAPS Gene

(5) SIMAP similar genes for CAPS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAPS: view

Variants for CAPS Gene

Sequence variations from dbSNP and Humsavar for CAPS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401154 -- 5,913,532(+) cctca(A/G)cttcc upstream-variant-2KB
rs10410179 -- 5,914,526(+) GGCCC(C/T)TGAGA intron-variant
rs10423464 -- 5,915,381(+) AGACC(C/T)CCCTT utr-variant-3-prime
rs111261114 -- 5,912,167(+) TTTTC(-/T)TTTTT upstream-variant-2KB
rs111490026 -- 5,912,667(+) TGGTG(C/T)GATCA upstream-variant-2KB

Variation tolerance for CAPS Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CAPS Gene

Disorders for CAPS Gene

Relevant External Links for CAPS

Genetic Association Database (GAD)
CAPS
Human Genome Epidemiology (HuGE) Navigator
CAPS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPS

No disorders were found for CAPS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPS Gene

Publications for CAPS Gene

  1. Cloning and sequence analysis of human calcyphosine complementary DNA. (PMID: 9224948) el Housni H. … Christophe D. (Biochim. Biophys. Acta 1997) 2 3 4 22 64
  2. Localization of human calcyphosine gene (CAPS) to the p13.3 region of chromosome 19 by in situ hybridization. (PMID: 2265558) Lefort A. … Mattei M.G. (Cytogenet. Cell Genet. 1990) 2 3 22 64
  3. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  4. Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family. (PMID: 18775726) Dong H. … Rao Z. (J. Mol. Biol. 2008) 3 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64

Products for CAPS Gene

  • Cloud-Clone Corp. Antibodies for CAPS
  • Cloud-Clone Corp. Proteins for CAPS
  • Cloud-Clone Corp Assay Kits for CAPS

Sources for CAPS Gene

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