CAPS Gene
protein-coding GIFtS: 50
GCID: GC19P005911
|
|
calcyphosine
| |
Aliases
for CAPS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcyphosine3 | | Calcyphosin1 | | Calcyphosine3 | | Calcyphosine 12 | | CAPS11 2 | | Thyroid Protein P242 | | MGC1265621 | | |
Export aliases for CAPS gene to outside databasesPrevious GC identifers: GC19P006006 GC19P005851 GC19P005865 GC19P005673 |
Summaries
for CAPS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CAPS:
This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similarprotein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5antigen in rabbit. Alternative splicing of this gene generates two transcript variants. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CAYP1_HUMAN, Q13938Function: Calcium-binding protein. May play a role in cellular signaling events (Potential)
Gene Wiki entry for CAPS
|
Genomic Views
for CAPS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CAPS gene promoter:
FAC1 AP-1 ATF-2 MIF-1 c-Jun Pax-4a C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAPS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3CAPS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P005911: view genomic region
(about GC identifiers)
Start:
|
5,911,718 bp from pter |
End:
|
5,916,222 bp from pter |
Size:
|
4,505 bases |
Orientation:
|
plus strand |
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Proteins
for CAPS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAYP1_HUMAN, Q13938 (See
protein sequence)Recommended Name: Calcyphosin Size: 189 amino acids; 20967 Da
Subunit: Monomer. Does not form oligomers in the presence of calcium
Subcellular location: Cytoplasm
1 PDB 3D structure from  and Proteopedia  for CAPS:3E3R (3D)
Secondary accessions: Q3MJA7 Q8WUZ3Explore the universe of human proteins at neXtProt for CAPS: NX_Q13938
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13938
CAPS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004049.1 NP_542157.1
ENSEMBL proteins: ENSP00000465883 ENSP00000222125 ENSP00000403263 ENSP00000468582
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CAPS for ontologies About GeneDecksing
CAPS Antibody Products:
Assay Products for CAPS: |
Protein
Domains /
Families
for CAPS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAPS for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13938ProtoNet protein and cluster: Q13938 UniProtKB/Swiss-Prot: CAYP1_HUMAN, Q13938Similarity: Contains 4 EF-hand domains |
Function
for CAPS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CAYP1_HUMAN, Q13938Function: Calcium-binding protein. May play a role in cellular signaling events (Potential) Genatlas biochemistry entry for CAPS:calcyphosine,calcium binding protein
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CAPS (NM_080590) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAPS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPS |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
CAPS for ontologies About GeneDecksing
|
Pathways & Interactions
for CAPS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAPS
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CAPS (ENSP000002221254) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035556 | intracellular signal transduction |
TAS | 2540953 |
CAPS for ontologies About GeneDecksing
|
Drugs & Compounds
for CAPS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CAPS
1 HMDB Compound for CAPS About this table
Search CenterWatch for drugs/clinical trials and news about CAPS / CAYP1
|
Transcripts
for CAPS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CAPS gene (2 alternative transcripts): NM_004058.3 NM_080590.2 Unigene Cluster for CAPS: Calcyphosine Hs.584744 [show with all ESTs]Unigene Representative Sequence: AK0904696 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000588776 ENST00000222125(uc002mdt.3) ENST00000452990(uc002mdu.3)
ENST00000590428 ENST00000585541 ENST00000588865
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CAPS (NM_080590) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAPS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPS |
Additional cDNA sequence: AK090469.1 AK123559.1 AK226026.1 BC011961.1 BC080599.1 BC101513.1 BC104766.1 X97966.1 6 DOTS entries: DT.312821 DT.97760083 DT.100659278 DT.99976177 DT.99975780 DT.95288317 24/186 AceView cDNA sequences (see all 186): AW151211 AI624988 BM716373 CF128141 BG950416 BU689238 CA396674 AI924700 BM699638 CR601253 CR623055 AI613142 AI628545 BM725337 BG767590 AI560810 CK821926 BM712749 BQ673321 BQ436748 AW510425 BQ673294 BE396135 AW513409
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CAPS About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
|---|
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| SP1: | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CAPS
|
Expression
for CAPS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CAPS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGACCAGAG
About this image
See CAPS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAPS
SOURCE GeneReport for Unigene cluster: Hs.584744
SABiosciences Custom PCR Arrays for CAPS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CAPS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPS |
Orthologs
for CAPS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CAPS gene from 2/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
capsla6 |
calcyphosine-like a |
55(a) |
1 ↔ 1 |
2(54479382-54485838) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG101263 |
calcium ion binding |
47(a) |
|
87D2 -- |
ENSEMBL Gene Tree for CAPS (if available)
TreeFam Gene Tree for CAPS (if available) |
Paralogs
for CAPS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CAPS gene
- CAPSL2 CAPS22
5 SIMAP similar genes for CAPS using alignment to 3 protein entries: CAYP1_HUMAN (see all proteins):FLJ00390 CAPSL CAPS2 SLC25A24 TNNC2
CAPS for paralogs About GeneDecksing
|
Genomic Variants
for CAPS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CAPS (5911718 - 5916222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CAPS: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAPS |
|
Disorders
/ Diseases
for CAPS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CAPS for disorders About GeneDecksing
OMIM gene information: 114212
OMIM disorders: --
4  diseases for CAPS: About MalaCardsthyroiditis anorexia nervosa antiphospholipid syndrome endometrial cancer
Human Genome Epidemiology (HuGE) Navigator: CAPS (43 documents)
Export disorders for CAPS gene to outside databases
|
Publications
for CAPS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CAPS gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CAPS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and sequence analysis of human calcyphosine complementary DNA. (PubMed id 9224948)1, 2, 3, 9 el Housni H.... Christophe D. (1997)
- Localization of human calcyphosine gene (CAPS) to the p13.3 region of chromosome 19 by in situ hybridization. (PubMed id 2265558)1, 3, 9 Lefort A....Mattei M.G. (1990)
- Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family. (PubMed id 18775726)1, 2 Dong H....Rao Z. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1 Pinheiro A.P....Woodside D.B. (2010)
- Crystallization and preliminary crystallographic analysis of recombinant human calcyphosine. (PubMed id 19275752)1 Dong H....Bartlam M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach. (PubMed id 18729184)1 Li Z....Zhao X. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CAPS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CAPS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CAPS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CAPS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CAPS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CAPS gene:
Search GeneIP for patents involving CAPS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAPS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CAPS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPS | | | OriGene Protein Over-expression Lysate for CAPS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CAPS | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CAPS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CAPS | | OriGene Custom Protein Services for CAPS | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAPS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAPS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPS |
| |
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| | | | Search Tocris compounds for CAPS |
| |  |  |  |  | | | | | | Recombinant Protein for CAPS |
|
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 |
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 | | | CAPS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPS |
|  |  |  | | | | Search ThermoFisher Antibodies for CAPS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPS |
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