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Aliases for CAPRIN1 Gene

Aliases for CAPRIN1 Gene

  • Cell Cycle Associated Protein 1 2 3
  • GPI-Anchored Membrane Protein 1 2 3 4
  • GPIAP1 3 4 6
  • M11S1 3 4 6
  • Cytoplasmic Activation- And Proliferation-Associated Protein 1 3 4
  • Cytoplasmic Activation/Proliferation-Associated Protein-1 2 3
  • Membrane Component, Chromosome 11, Surface Marker 1 2 3
  • Membrane Component Chromosome 11 Surface Marker 1 3 4
  • Cell Cycle-Associated Protein 1 3 4
  • GPI-Anchored Protein P137 3 4
  • RNA Granule Protein 105 3 4
  • GPI-P137 3 4
  • GRIP137 3 6
  • GPIP137 3 4
  • P137GPI 3 4
  • RNG105 3 4
  • Activation/Proliferation-Associated Protein 1 3
  • Caprin 1 3
  • Caprin-1 3

External Ids for CAPRIN1 Gene

Previous Symbols for CAPRIN1 Gene

  • M11S1
  • GPIAP1

Summaries for CAPRIN1 Gene

GeneCards Summary for CAPRIN1 Gene

CAPRIN1 (Cell Cycle Associated Protein 1) is a Protein Coding gene. Diseases associated with CAPRIN1 include japanese encephalitis. GO annotations related to this gene include RNA binding. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for CAPRIN1 Gene

  • May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types.

Gene Wiki entry for CAPRIN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPRIN1 Gene

Genomics for CAPRIN1 Gene

Genomic Location for CAPRIN1 Gene

Start:
34,051,683 bp from pter
End:
34,102,610 bp from pter
Size:
50,928 bases
Orientation:
Plus strand

Genomic View for CAPRIN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPRIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPRIN1 Gene

Regulatory Elements for CAPRIN1 Gene

Proteins for CAPRIN1 Gene

  • Protein details for CAPRIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14444-CAPR1_HUMAN
    Recommended name:
    Caprin-1
    Protein Accession:
    Q14444
    Secondary Accessions:
    • A6NMY7
    • D3DR06
    • Q15074
    • Q6IMN4
    • Q6IMN7
    • Q9BV09

    Protein attributes for CAPRIN1 Gene

    Size:
    709 amino acids
    Molecular mass:
    78366 Da
    Quaternary structure:
    • May form homomultimers. Directly interacts with G3BP1 in cytoplasmic RNA granules. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity).
    Miscellaneous:
    • Overexpression induces the formation of cytoplasmic stress granules and EIF2A phosphorylation through a mechanism that depends on its ability to bind mRNA
    SequenceCaution:
    • Sequence=CAA61751.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA88096.1; Type=Frameshift; Positions=11, 629; Evidence={ECO:0000305};

    Alternative splice isoforms for CAPRIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPRIN1 Gene

Proteomics data for CAPRIN1 Gene at MOPED

Post-translational modifications for CAPRIN1 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys74, Lys110, Lys125, and Lys147

Other Protein References for CAPRIN1 Gene

No data available for DME Specific Peptides for CAPRIN1 Gene

Domains for CAPRIN1 Gene

Protein Domains for CAPRIN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAPRIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14444

UniProtKB/Swiss-Prot:

CAPR1_HUMAN
Family:
  • Belongs to the caprin family.:
    • Q14444
genes like me logo Genes that share domains with CAPRIN1: view

No data available for Gene Families for CAPRIN1 Gene

Function for CAPRIN1 Gene

Molecular function for CAPRIN1 Gene

UniProtKB/Swiss-Prot Function: May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types.

Gene Ontology (GO) - Molecular Function for CAPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CAPRIN1: view
genes like me logo Genes that share phenotypes with CAPRIN1: view

Animal Models for CAPRIN1 Gene

MGI Knock Outs for CAPRIN1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CAPRIN1 Gene

Localization for CAPRIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPRIN1 Gene

Cytoplasm, cytosol. Cell projection, dendrite. Note=Associated with RNA granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPRIN1 Gene COMPARTMENTS Subcellular localization image for CAPRIN1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CAPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0005887 integral component of plasma membrane TAS 7657653
GO:0010494 cytoplasmic stress granule ISS --
genes like me logo Genes that share ontologies with CAPRIN1: view

Pathways for CAPRIN1 Gene

SuperPathways for CAPRIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017148 negative regulation of translation ISS --
GO:0050775 positive regulation of dendrite morphogenesis ISS --
GO:0061003 positive regulation of dendritic spine morphogenesis ISS --
genes like me logo Genes that share ontologies with CAPRIN1: view

No data available for Pathways by source for CAPRIN1 Gene

Transcripts for CAPRIN1 Gene

Unigene Clusters for CAPRIN1 Gene

Cell cycle associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPRIN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - - - - - -
SP8:
SP9: - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - - -
SP15:

ExUns: 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: - - - - - - - - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CAPRIN1 Gene

GeneLoc Exon Structure for
CAPRIN1
ECgene alternative splicing isoforms for
CAPRIN1

Expression for CAPRIN1 Gene

mRNA expression in normal human tissues for CAPRIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPRIN1 Gene

SOURCE GeneReport for Unigene cluster for CAPRIN1 Gene Hs.471818

mRNA Expression by UniProt/SwissProt for CAPRIN1 Gene

Q14444-CAPR1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CAPRIN1: view

No data available for mRNA differential expression in normal tissues for CAPRIN1 Gene

Orthologs for CAPRIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPRIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPRIN1 35
  • 100 (n)
  • 100 (a)
CAPRIN1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPRIN1 35
  • 94.93 (n)
  • 97.62 (a)
CAPRIN1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPRIN1 35
  • 95.62 (n)
  • 98.51 (a)
CAPRIN1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Caprin1 35
  • 91.69 (n)
  • 97.01 (a)
Caprin1 16
Caprin1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPRIN1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPRIN1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Caprin1 35
  • 91.94 (n)
  • 96.57 (a)
chicken
(Gallus gallus)
Aves CAPRIN1 35
  • 83.94 (n)
  • 90.18 (a)
CAPRIN1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPRIN1 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia m11s1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia caprin1 35
  • 73.04 (n)
  • 77.67 (a)
Str.6417 35
zebrafish
(Danio rerio)
Actinopterygii caprin1a 36
  • 57 (a)
OneToMany
caprin1b 35
  • 66.61 (n)
  • 63.26 (a)
caprin1b 36
  • 58 (a)
OneToMany
Dr.941 35
fruit fly
(Drosophila melanogaster)
Insecta Capr 36
  • 18 (a)
OneToMany
Species with no ortholog for CAPRIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPRIN1 Gene

ENSEMBL:
Gene Tree for CAPRIN1 (if available)
TreeFam:
Gene Tree for CAPRIN1 (if available)

Paralogs for CAPRIN1 Gene

Selected SIMAP similar genes for CAPRIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPRIN1: view

Variants for CAPRIN1 Gene

Sequence variations from dbSNP and Humsavar for CAPRIN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8191 -- 34,098,680(+) AGGAT(A/G)TTTGC intron-variant, utr-variant-3-prime
rs10436 -- 34,101,819(-) AAAAT(A/G)TGCAT utr-variant-3-prime
rs11710 -- 34,097,200(-) TCATA(C/T)CCTCC reference, synonymous-codon
rs15328 -- 34,098,779(-) ACTTT(A/T)TACAT intron-variant, utr-variant-3-prime
rs958332 -- 34,062,863(-) TGGCT(A/T)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPRIN1 Gene

Variant ID Type Subtype PubMed ID
esv2744334 CNV Deletion 23290073

Relevant External Links for CAPRIN1 Gene

HapMap Linkage Disequilibrium report
CAPRIN1
Human Gene Mutation Database (HGMD)
CAPRIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPRIN1 Gene

Disorders for CAPRIN1 Gene

(1) MalaCards Diseases for CAPRIN1 Gene

Search for CAPRIN1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CAPRIN1 Gene

genes like me logo Genes that share disorders with CAPRIN1: view

No data available for UniProtKB/Swiss-Prot for CAPRIN1 Gene

Publications for CAPRIN1 Gene

  1. Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs. (PMID: 17210633) Solomon S. … Schrader J.W. (Mol. Cell. Biol. 2007) 2 3 4 23
  2. The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse. (PMID: 8786113) Gessler M. … Luzio J.P. (Genomics 1996) 3 4 23
  3. Absence of caprin-1 results in defects in cellular proliferation. (PMID: 16177067) Wang B. … Schrader J.W. (J. Immunol. 2005) 2 3 23
  4. Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells. (PMID: 7657653) Ellis J.A. … Luzio J.P. (J. Biol. Chem. 1995) 2 3 4
  5. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. (PMID: 14764709) Grill B. … Schrader J.W. (J. Immunol. 2004) 2 3 4

Products for CAPRIN1 Gene

Sources for CAPRIN1 Gene

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