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CAPRIN1 Gene

protein-coding   GIFtS: 55
GCID: GC11P034031

Cell Cycle Associated Protein 1

(Previous names: membrane component, chromosome 11, surface marker 1, GPI-anchored...)
(Previous symbols: M11S1, GPIAP1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Cycle Associated Protein 11 2     GPIP1372 3
GPIAP11 2 3 5     RNG1052 3
M11S11 2 3 5     GPI-Anchored Protein P1372 3
GPI-Anchored Membrane Protein 11 2 3     p137GPI2 3
Membrane Component, Chromosome 11, Surface Marker 11 2     RNA Granule Protein 1052 3
Cytoplasmic Activation/Proliferation-Associated Protein-11 2     GRIP1372 5
Cell Cycle-Associated Protein 12 3     Activation/Proliferation-Associated Protein 12
Cytoplasmic Activation- And Proliferation-Associated Protein 12 3     Caprin 12
Membrane Component Chromosome 11 Surface Marker 12 3     caprin-12
GPI-p1372 3     

External Ids:    HGNC: 67431   Entrez Gene: 40762   Ensembl: ENSG000001353877   OMIM: 6011785   UniProtKB: Q144443   

Export aliases for CAPRIN1 gene to outside databases

Previous GC identifer: GC11P033769


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CAPRIN1 Gene:
CAPRIN1 (cell cycle associated protein 1) is a protein-coding gene. Diseases associated with CAPRIN1 include japanese encephalitis, and smallpox. GO annotations related to this gene include RNA binding. An important paralog of this gene is CBLN2.

UniProtKB/Swiss-Prot: CAPR1_HUMAN, Q14444
Function: May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in
neurons and cell proliferation and migration in multiple cell types (By similarity)

Gene Wiki entry for CAPRIN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAPRIN1 gene promoter:
         HNF-4alpha2   Roaz   YY1   HNF-4alpha1   Egr-4   RORalpha2   MZF-1   USF-1   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPRIN1 promoter sequence
   Search Chromatin IP Primers for CAPRIN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPRIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

CAPRIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPRIN1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P034031:  view genomic region     (about GC identifiers)

Start:
34,073,230 bp from pter      End:
34,124,157 bp from pter
Size:
50,928 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CAPR1_HUMAN, Q14444 (See protein sequence)
Recommended Name: Caprin-1  
Size: 709 amino acids; 78366 Da
Subunit: May form homomultimers. Directly interacts with G3BP1 in cytoplasmic RNA granules. Binds directly and
selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA
granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs
(By similarity)
Miscellaneous: Overexpression induces the formation of cytoplasmic stress granules and EIF2A phosphorylation
through a mechanism that depends on its ability to bind mRNA
Caution: Was originally (PubMed:7657653) thought to be a GPI-anchored membrane protein
Sequence caution: Sequence=CAA61751.1; Type=Erroneous gene model prediction; Sequence=CAA88096.1; Type=Frameshift;
Positions=11, 629;
Secondary accessions: A6NMY7 D3DR06 Q15074 Q6IMN4 Q6IMN7 Q9BV09
Alternative splicing: 2 isoforms:  Q14444-1   Q14444-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAPRIN1: NX_Q14444

Explore proteomics data for CAPRIN1 at MOPED

Post-translational modifications: 

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner1
  • Ubiquitination2 at Lys74, Lys110, Lys125, Lys147
  • Modification sites at PhosphoSitePlus

  • See CAPRIN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005889.3  NP_976240.1  

    ENSEMBL proteins: 
     ENSP00000340329   ENSP00000374296   ENSP00000431373   ENSP00000434150   ENSP00000434204  
     ENSP00000431581  

    CAPRIN1 Human Recombinant Protein Products:

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    Novus Biologicals CAPRIN1 Protein
    Novus Biologicals CAPRIN1 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CAPRIN1

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    LSBio Antibodies in human, mouse, rat for CAPRIN1

    CAPRIN1 Assay Products:

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    Cloud-Clone Corp. CLIAs for CAPRIN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR022070 Caprin-1_C
     IPR028816 Caprin

    Graphical View of Domain Structure for InterPro Entry Q14444

    ProtoNet protein and cluster: Q14444

    UniProtKB/Swiss-Prot: CAPR1_HUMAN, Q14444
    Similarity: Belongs to the caprin family


    CAPRIN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAPR1_HUMAN, Q14444
    Function: May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in
    neurons and cell proliferation and migration in multiple cell types (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ISS--
    GO:0044822poly(A) RNA binding IDA--
         
    CAPRIN1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CAPRIN1:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Caprin1):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  mortality/aging 
     nervous system  respiratory system 

    CAPRIN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Caprin1tm1Mtok for CAPRIN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPRIN1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPRIN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPRIN1

    miRNA
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    miRTarBase miRNAs that target CAPRIN1:
    hsa-mir-484 (MIRT042167), hsa-mir-34a-5p (MIRT025338), hsa-mir-1 (MIRT023918), hsa-mir-92a-3p (MIRT049828), hsa-mir-92b-3p (MIRT040683), hsa-mir-21-5p (MIRT030874), hsa-mir-124-3p (MIRT022856), hsa-mir-222-3p (MIRT046795), hsa-mir-1296-5p (MIRT036082), hsa-mir-16-5p (MIRT005086)

    Block miRNA regulation of human, mouse, rat CAPRIN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPRIN1 (see all 180):
    hsa-miR-124* hsa-miR-640 hsa-miR-193a-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-519a hsa-miR-3916 hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat CAPRIN1

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPRIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPRIN1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPRIN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAPR1_HUMAN, Q14444: Cytoplasm, cytosol. Cell projection, dendrite. Note=Associated with RNA granules (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane4
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0005887integral component of plasma membrane TAS7657653
    GO:0010494cytoplasmic stress granule ISS--

    CAPRIN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAPRIN1
    Interactions:

        Search GeneGlobe Interaction Network for CAPRIN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for CAPRIN1 (Q144442, 3 ENSP000003403294) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    G3BP1Q132832, 3, ENSP000003485784MINT-6741129 I2D: score=2 STRING: ENSP00000348578
    WBP4O755542, 3, ENSP000003688014MINT-73066 I2D: score=3 STRING: ENSP00000368801
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    GIGYF2Q6Y7W63, ENSP000003871704I2D: score=1 STRING: ENSP00000387170
    PIN1Q135263, ENSP000002479704I2D: score=2 STRING: ENSP00000247970
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017148negative regulation of translation ISS--
    GO:0050775positive regulation of dendrite morphogenesis ISS--
    GO:0061003positive regulation of dendritic spine morphogenesis ISS--

    CAPRIN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAPRIN1 (CAPR1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAPRIN1 gene (2 alternative transcripts): 
    NM_005898.4  NM_203364.2  

    Unigene Cluster for CAPRIN1:

    Cell cycle associated protein 1
    Hs.471818  [show with all ESTs]
    Unigene Representative Sequence: NM_005898
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341394(uc001mvh.1 uc001mvi.2 uc001mvj.1) ENST00000526477
    ENST00000389645(uc001mvg.3) ENST00000528856 ENST00000534042 ENST00000534825
    ENST00000532820 ENST00000530820 ENST00000529307 ENST00000526494 ENST00000532755
    ENST00000533641 ENST00000530008 ENST00000533657 ENST00000528948 ENST00000531668
    ENST00000533562
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CAPRIN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPRIN1 (see all 180):
    hsa-miR-124* hsa-miR-640 hsa-miR-193a-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-519a hsa-miR-3916 hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 2): CAPRIN1 (NM_203364)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAPRIN1
      QuantiTect SYBR Green Assays in human, mouse, rat CAPRIN1
      QuantiFast Probe-based Assays in human, mouse, rat CAPRIN1

    Additional mRNA sequence: 

    AF086078.1 AK074309.1 AK127972.1 AK299720.1 BC001731.1 BC015700.1 BC026302.1 U51714.1 
    Z48042.1 

    Selected DOTS entries (see all 46):

    DT.87017561  DT.95074048  DT.95157379  DT.91777802  DT.100877964  DT.95157490  DT.120736999  DT.120736934 
    DT.120736947  DT.95157487  DT.120736984  DT.442246  DT.99940576  DT.95157388  DT.92401905  DT.95313228 
    DT.405618  DT.95149559  DT.120736925  DT.120736968  DT.95151090  DT.95157452  DT.40206505  DT.91777800 

    Selected AceView cDNA sequences (see all 780):

    CD652788 BU683273 CA422528 BG777475 AA885580 BP338793 AA928661 AW470483 
    AI655422 BQ574547 BQ690634 AA405070 BX279797 AI337310 BE327513 AA306143 
    BM672938 CK299214 AA359015 N75379 BP364918 BG260149 BG954060 AA313212 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAPRIN1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^
    SP1:                          -     -                 -     -     -     -     -     -     -                                                                     
    SP2:                          -     -                 -     -     -     -     -     -     -                                                                     
    SP3:                                                  -     -     -     -     -     -     -                                                                     
    SP4:                                                              -     -     -     -     -                                                                     
    SP5:                                                                    -     -     -     -                                                                     

    ExUns: 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
    SP1:                                                  -                                         -                     
    SP2:                                                  -                                                               
    SP3:                                                  -                                         -                     
    SP4:                                                  -                                         -                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for CAPRIN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAPRIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAATTAAT
    CAPRIN1 Expression
    About this image


    CAPRIN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Ovary (Reproductive System)
             Primary Oocyte Primordial Follicle
     
     Gonad
             Primary Oocyte Primordial Follicle
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    CAPRIN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPRIN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471818

    UniProtKB/Swiss-Prot: CAPR1_HUMAN, Q14444
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPRIN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CAPRIN1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Caprin11 , 5 cell cycle associated protein 11, 5 91.69(n)1
    97.01(a)1
      2 (54.43 cM)5
    538721  NM_016739.31  NP_058019.21 
     1037629415 
    chicken
    (Gallus gallus)
    Aves CAPRIN11 cell cycle associated protein 1 83.94(n)
    90.18(a)
      426151  NM_001031365.1  NP_001026536.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAPRIN16
    cell cycle associated protein 1
    85(a)
    1 ↔ 1
    GL343283.1(1123701-1156477)
    African clawed frog
    (Xenopus laevis)
    Amphibia m11s1-prov2 membrane component, chromosome 11, surface marker 1 77.78(n)    AB128031.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.9412 Danio rerio mRNA similar to membrane component, chromosome more 75.97(n)    BC047196.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Capr6
    Caprin
    18(a)
    1 → many
    3L(18661253-18666260)


    ENSEMBL Gene Tree for CAPRIN1 (if available)
    TreeFam Gene Tree for CAPRIN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAPRIN1 gene
    CBLN22  C1QL32  CBLN12  C1QTNF32  ENSG000002732942  C1QL22  CBLN32  CAPRIN22  
    C1QL12  CBLN42  C1QL42  
    2 SIMAP similar genes for CAPRIN1 using alignment to 4 protein entries:     CAPR1_HUMAN (see all proteins):
    CAPRIN2    DKFZp686D159

    CAPRIN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAPRIN1 (see all 1175)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906517021,2
    --34071253(+) CTTGGC/TTTCCC 2 -- us2k10--------
    rs1511411411,2
    --34071263(+) CAAAGC/TGTTGG 2 -- us2k10--------
    rs124196291,2
    C,A,H--34071279(+) caggcA/Gtgagc 2 -- us2k14Minor allele frequency- G:0.24NA WA 242
    rs1827383581,2
    --34071338(+) TTTTTC/TTGTAA 2 -- us2k10--------
    rs1401437301,2
    --34071346(+) TAAAAC/GAAGAG 2 -- us2k10--------
    rs734970171,2
    C,F--34071398(+) CCCAAG/CTACTC 2 -- us2k13Minor allele frequency- C:0.24WA NA 240
    rs1453251871,2
    --34071418(+) GTGCTA/GTGGCA 2 -- us2k10--------
    rs559603961,2
    F--34071645(+) AACTTT/AGAGTT 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1168644471,2
    C,F--34071673(+) TATCAT/CCTCCG 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1379560251,2
    --34071797(+) CCGTGA/GTCTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAPRIN1 (34073230 - 34124157 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CAPRIN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744334CNV Deletion23290073

    Human Gene Mutation Database (HGMD): CAPRIN1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CAPRIN1
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPRIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601178    OMIM disorders: --

    10 diseases for CAPRIN1:    
    About MalaCards
    japanese encephalitis    smallpox    vaccinia    encephalitis
    mental retardation    osteosarcoma    hiv-1    neuronitis
    breast cancer    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for CAPRIN1:
    Smallpox

    CAPRIN1 for disorders           About GeneDecksing


    Export disorders for CAPRIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAPRIN1 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with CAPRIN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs. (PubMed id 17210633)1, 2, 3, 9 Solomon S....Schrader J.W. (Mol. Cell. Biol. 2007)
    2. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. (PubMed id 14764709)1, 2, 3 Grill B....Schrader J.W. (J. Immunol. 2004)
    3. Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells. (PubMed id 7657653)1, 2, 3 Ellis J.A. and Luzio J.P. (J. Biol. Chem. 1995)
    4. Absence of caprin-1 results in defects in cellular proliferation. (PubMed id 16177067)1, 3, 9 Wang B....Schrader J.W. (J. Immunol. 2005)
    5. The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse. (PubMed id 8786113)1, 2, 9 Gessler M.... Luzio J.P. (Genomics 1996)
    6. RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. (PubMed id 20516077)1, 2 Shiina N. and Tokunaga M. (J. Biol. Chem. 2010)
    7. Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer. (PubMed id 15471883)1, 3 Katsafanas G.C. and Moss B. (J. Biol. Chem. 2004)
    8. Two new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferation. (PubMed id 19250063)1, 9 Kaddar T....Magaud J.P. (Biol. Cell 2009)
    9. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4076 HGNC: 6743 AceView: M11S1 Ensembl:ENSG00000135387 euGenes: HUgn4076
    ECgene: CAPRIN1 H-InvDB: CAPRIN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAPRIN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAPRIN1 gene:
    Search GeneIP for patents involving CAPRIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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