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Aliases for CAPNS2 Gene

Aliases for CAPNS2 Gene

  • Calpain, Small Subunit 2 2 3
  • Calcium-Dependent Protease Small Subunit 2 3 4
  • CSS2 3 4
  • Calpain Small Subunit 2 3

External Ids for CAPNS2 Gene

Summaries for CAPNS2 Gene

GeneCards Summary for CAPNS2 Gene

CAPNS2 (Calpain, Small Subunit 2) is a Protein Coding gene. Diseases associated with CAPNS2 include traumatic brain injury and malaria. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPNS2 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity

Tocris Summary for CAPNS2 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimers disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPNS2 Gene

Genomics for CAPNS2 Gene

Genomic Location for CAPNS2 Gene

Start:
55,566,672 bp from pter
End:
55,567,687 bp from pter
Size:
1,016 bases
Orientation:
Plus strand

Genomic View for CAPNS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPNS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPNS2 Gene

Regulatory Elements for CAPNS2 Gene

Proteins for CAPNS2 Gene

  • Protein details for CAPNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L46-CPNS2_HUMAN
    Recommended name:
    Calpain small subunit 2
    Protein Accession:
    Q96L46
    Secondary Accessions:
    • Q9BPV4

    Protein attributes for CAPNS2 Gene

    Size:
    248 amino acids
    Molecular mass:
    27660 Da
    Quaternary structure:
    • Heterodimer of a large (catalytic) and a small (regulatory) subunit

neXtProt entry for CAPNS2 Gene

Proteomics data for CAPNS2 Gene at MOPED

Post-translational modifications for CAPNS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPNS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAPNS2 Gene

Domains for CAPNS2 Gene

Gene Families for CAPNS2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CAPNS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAPNS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96L46

UniProtKB/Swiss-Prot:

CPNS2_HUMAN
Domain:
  • Contains 4 EF-hand domains.:
    • Q96L46
genes like me logo Genes that share domains with CAPNS2: view

Function for CAPNS2 Gene

Molecular function for CAPNS2 Gene

UniProtKB/Swiss-Prot Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity

Gene Ontology (GO) - Molecular Function for CAPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CAPNS2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CAPNS2 Gene

Localization for CAPNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPNS2 Gene

Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for CAPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CAPNS2: view

No data available for Subcellular locations from COMPARTMENTS for CAPNS2 Gene

Pathways for CAPNS2 Gene

SuperPathways for CAPNS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with CAPNS2: view

No data available for Pathways by source for CAPNS2 Gene

Compounds for CAPNS2 Gene

(5) Tocris Compounds for CAPNS2 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor [123714-50-1]
MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
MG 101 Calpain inhibitor; activates p53-dependent apoptosis [110044-82-1]
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation [133407-82-6]
PD 150606 Cell permeable calpain inhibitor [179528-45-1]

(1) HMDB Compounds for CAPNS2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CAPNS2: view

Transcripts for CAPNS2 Gene

mRNA/cDNA for CAPNS2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(135) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAPNS2 Gene

Calpain, small subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPNS2 Gene

No ASD Table

Relevant External Links for CAPNS2 Gene

GeneLoc Exon Structure for
CAPNS2
ECgene alternative splicing isoforms for
CAPNS2

Expression for CAPNS2 Gene

mRNA expression in normal human tissues for CAPNS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPNS2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (14.0), Skin - Sun Exposed (Lower leg) (12.8), Esophagus - Mucosa (12.5), and Vagina (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAPNS2 Gene

SOURCE GeneReport for Unigene cluster for CAPNS2 Gene Hs.660027

genes like me logo Genes that share expressions with CAPNS2: view

No data available for mRNA Expression by UniProt/SwissProt for CAPNS2 Gene

Orthologs for CAPNS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPNS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPNS2 35
  • 99.6 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CAPNS2 35
  • 87.67 (n)
  • 89.84 (a)
dog
(Canis familiaris)
Mammalia CAPNS2 35
  • 87.5 (n)
  • 90.73 (a)
mouse
(Mus musculus)
Mammalia Capns2 35
  • 86.1 (n)
  • 92.31 (a)
Capns2 16
Capns2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capns2 35
  • 85.29 (n)
  • 89.47 (a)
chicken
(Gallus gallus)
Aves CAPNS2 35
  • 71.12 (n)
  • 70.04 (a)
zebrafish
(Danio rerio)
Actinopterygii capns1a 36
  • 60 (a)
ManyToMany
capns1b 36
  • 60 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012067 35
  • 50.56 (n)
  • 38.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4609 36
  • 11 (a)
OneToMany
Species with no ortholog for CAPNS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPNS2 Gene

ENSEMBL:
Gene Tree for CAPNS2 (if available)
TreeFam:
Gene Tree for CAPNS2 (if available)

Paralogs for CAPNS2 Gene

Selected SIMAP similar genes for CAPNS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CAPNS2: view

Variants for CAPNS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAPNS2 Gene

Variant ID Type Subtype PubMed ID
nsv521337 CNV Loss 19592680

Relevant External Links for CAPNS2 Gene

HapMap Linkage Disequilibrium report
CAPNS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CAPNS2 Gene

Disorders for CAPNS2 Gene

Relevant External Links for CAPNS2

Genetic Association Database (GAD)
CAPNS2
Human Genome Epidemiology (HuGE) Navigator
CAPNS2
genes like me logo Genes that share disorders with CAPNS2: view

No data available for UniProtKB/Swiss-Prot for CAPNS2 Gene

Publications for CAPNS2 Gene

  1. A novel human small subunit of calpains. (PMID: 11853546) Schad E. … Friedrich P. (Biochem. J. 2002) 2 3 4 23
  2. Expression of calpain small subunit 2 in mammalian tissues. (PMID: 15590481) Ma H. … Shearer T.R. (Curr. Eye Res. 2004) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CAPNS2 Gene

Sources for CAPNS2 Gene

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