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CAPNS2 Gene

protein-coding   GIFtS: 47
GCID: GC16P055655

Calpain, Small Subunit 2

  See CAPNS2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calpain, Small Subunit 21 2
Calcium-Dependent Protease Small Subunit 22 3
CSS22 3
Calpain Small Subunit 22

External Ids:    HGNC: 163711   Entrez Gene: 842902   Ensembl: ENSG000002568127   UniProtKB: Q96L463   

Export aliases for CAPNS2 gene to outside databases

Previous GC identifers: GC16P046015 GC16P055338 GC16P055379 GC16P054158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CAPNS2 Gene:
CAPNS2 (calpain, small subunit 2) is a protein-coding gene. Diseases associated with CAPNS2 include traumatic brain injury. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CAPN6.

UniProtKB/Swiss-Prot: CPNS2_HUMAN, Q96L46
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates
involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific
chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity

summary for CAPNS2 Gene:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAPNS2 gene promoter:
         CUTL1   Meis-1b   POU2F1   HSF2   POU2F1a   Sox9   Meis-1a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CAPNS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPNS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

CAPNS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPNS2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P055655:  view genomic region     (about GC identifiers)

Start:
55,600,584 bp from pter      End:
55,601,599 bp from pter
Size:
1,016 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CPNS2_HUMAN, Q96L46 (See protein sequence)
Recommended Name: Calpain small subunit 2  
Size: 248 amino acids; 27660 Da
Subunit: Heterodimer of a large (catalytic) and a small (regulatory) subunit
Secondary accessions: Q9BPV4

Explore the universe of human proteins at neXtProt for CAPNS2: NX_Q96L46

Explore proteomics data for CAPNS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CAPNS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115706.1  
    ENSEMBL proteins: 
     ENSP00000400882  

    CAPNS2 Human Recombinant Protein Products:

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    Novus Biologicals CAPNS2 Protein
    Novus Biologicals CAPNS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAPNS2

     
    Search eBioscience for Proteins for CAPNS2 

     
    antibodies-online proteins for CAPNS2 (4 products) 

     
    antibodies-online peptides for CAPNS2

    CAPNS2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CAPNS2
    antibodies-online antibodies for CAPNS2 (13 products) 

    CAPNS2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAPNS2
    Cloud-Clone Corp. CLIAs for CAPNS2
    Search eBioscience for ELISAs for CAPNS2 
    antibodies-online kits for CAPNS2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry Q96L46

    ProtoNet protein and cluster: Q96L46

    UniProtKB/Swiss-Prot: CPNS2_HUMAN, Q96L46
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with CAPNS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPNS2_HUMAN, Q96L46
    Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates
    involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific
    chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IBA--
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with CAPNS2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPNS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAPNS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPNS2
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    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CAPNS2

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    GenScript: all cDNA clones in your preferred vector: CAPNS2 (NM_032330)
    Sino Biological Human cDNA Clone for CAPNS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPNS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPNS2

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPNS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CPNS2_HUMAN, Q96L46: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocates to the plasma
    membrane upon calcium binding (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with CAPNS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAPNS2
    Interactions:

        Search GeneGlobe Interaction Network for CAPNS2

    1 Interacting protein for CAPNS2 (Q96L463) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPN2P176553I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IBA--

    Find genes that share ontologies with CAPNS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CAPNS2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    PD 150606Cell permeable calpain inhibitor[179528-45-1]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPNS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAPNS2 gene: 
    NM_032330.1  

    Unigene Cluster for CAPNS2:

    Calpain, small subunit 2
    Hs.660027  [show with all ESTs]
    Unigene Representative Sequence: BM914030
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000457326(uc002eid.1)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCAPNS2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CAPNS2
    Predesigned siRNA for gene silencing in human, mouse, rat CAPNS2
    Clone
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    GenScript: all cDNA clones in your preferred vector: CAPNS2 (NM_032330)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPNS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPNS2
    Primer
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    OriGene qPCR primer pairs and template standards for CAPNS2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAPNS2
      QuantiTect SYBR Green Assays in human, mouse, rat CAPNS2
      QuantiFast Probe-based Assays in human, mouse, rat CAPNS2

    Additional mRNA sequence: 

    AY052551.1 BC005397.1 BC006000.1 

    1 DOTS entry:

    DT.408239 

    Selected AceView cDNA sequences (see all 135):

    BX118074 BQ720497 BE272481 BM914235 NM_032330 AW472912 AA450333 BG679603 
    N70822 BC002472 BU195114 BF438871 BC005397 CA748632 BQ017492 BC005981 
    NM_017839 AL601202 BC006000 BX641069 AW241581 AI189011 AI310758 BE327017 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAPNS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCCTTT
    CAPNS2 Expression
    About this image


    CAPNS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    CAPNS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPNS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660027
        Custom PCR Arrays for CAPNS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPNS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CAPNS2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capns21 , 5 calpain, small subunit 21, 5 86.1(n)1
    92.31(a)1
      8 (44.99 cM)5
    695431  NM_027112.11  NP_081388.11 
     929014075 
    chicken
    (Gallus gallus)
    Aves CAPNS21 calpain, small subunit 2 71.12(n)
    70.04(a)
      770982  XM_004944171.1  XP_004944228.1 
    zebrafish
    (Danio rerio)
    Actinopterygii capns1a6
    capns1b6
    calpain, small subunit 1 b
    60(a)
    60(a)
    many ↔ many
    many ↔ many
    5(38254980-38265857) ENSDARG00000035329
    15(28465157-28471924) ENSDARG00000013804
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0120671 AgaP_AGAP012067 50.56(n)
    38.89(a)
      1280602  XM_320457.3  XP_320457.3 


    ENSEMBL Gene Tree for CAPNS2 (if available)
    TreeFam Gene Tree for CAPNS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAPNS2 gene
    CAPN62  CAPN82  CAPN142  CAPNS12  CAPN132  CAPN12  CAPN52  CAPN92  
    CAPN32  CAPN22  CAPN122  CAPN112  CAPN102  
    10 SIMAP similar genes for CAPNS2 using alignment to 1 protein entry:     CPNS2_HUMAN:
    CAPNS1    CAPN3    CAPN11    CAPN1    CAPN2    CAPN9
    CAPN8    PDCD6    SRI    GCA

    Find genes that share paralogs with CAPNS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CAPNS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521337CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CAPNS2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPNS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for CAPNS2:    
    About MalaCards
    traumatic brain injury


    Find genes that share disorders with CAPNS2           About GenesLikeMe

    Genetic Association Database (GAD): CAPNS2
    Human Genome Epidemiology (HuGE) Navigator: CAPNS2 (3 documents)

    Export disorders for CAPNS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAPNS2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CAPNS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human small subunit of calpains. (PubMed id 11853546)1, 2, 3, 9 Schad E.... Friedrich P. (Biochem. J. 2002)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Expression of calpain small subunit 2 in mammalian tissues. (PubMed id 15590481)1, 9 Ma H....Shearer T.R. (Curr. Eye Res. 2004)
    5. A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. (PubMed id 23408906)1 Porcu E....Naitza S. (PLoS Genet. 2013)
    6. Calpain expression in the brain cortex after traumatic brain injury. (PubMed id 23390828)1 BraliA8 M. and Stemberga V. (Coll Antropol 2012)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84290 HGNC: 16371 AceView: FLJ20481 Ensembl:ENSG00000256812 euGenes: HUgn84290
    ECgene: CAPNS2 H-InvDB: CAPNS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAPNS2 Pharmacogenomics, SNPs, Pathways
    Calpains homepagehttp://ag.arizona.edu/calpains/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAPNS2 gene:
    Search GeneIP for patents involving CAPNS2

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CAPNS2  
     OriGene qPCR primer pairs and template standards for CAPNS2   OriGene Protein Over-expression Lysate for CAPNS2  
     OriGene MassSpec for CAPNS2   OriGene clones in human, mouse for CAPNS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CAPNS2   OriGene Purified Protein for CAPNS2  
     OriGene ORF clones in mouse, rat for CAPNS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CAPNS2   OriGene Custom Protein Services for CAPNS2  

     
     
     Block miRNA regulation of human, mouse, rat CAPNS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CAPNS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPNS2 Predesigned siRNA for gene silencing in human, mouse, rat CAPNS2
     QuantiFast Probe-based Assays in human, mouse, rat CAPNS2 QuantiTect SYBR Green Assays in human, mouse, rat CAPNS2
     Custom PCR Arrays for CAPNS2 Search Chromatin IP Primers for CAPNS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAPNS2  Search GeneGlobe Interaction Network for CAPNS2
     Regulatory tfbs in CAPNS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CAPNS2 GenScript cDNA clones with any tag delivered in your preferred vector for CAPNS2
     GenScript Custom Assay Services for CAPNS2 GenScript Custom overexpressing Cell Line Services for CAPNS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for CAPNS2
     Browse Sino Biological Proteins
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     cDNA Clones for CAPNS2
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     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CAPNS2 antibodies
     CAPNS2 proteins
     CAPNS2 lysates
     Antibodies for CAPNS2
     See all of Abcam's Antibodies, Kits and Proteins for CAPNS2
     Custom Antibody / Protein Production Service
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CAPNS2
     Antibodies for CAPNS2
     ELISAs for CAPNS2
     CLIAs for CAPNS2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CAPNS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPNS2
     SwitchGear 3'UTR luciferase reporter plasmids for CAPNS2
     Browse SwitchGear Promoter luciferase reporter plasmids for CAPNS2
     Search ThermoFisher Antibodies for CAPNS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPNS2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPNS2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAPNS2
     LSBio Antibodies in human, mouse, rat for CAPNS2
     Browse compounds at ApexBio
     Search Addgene for plasmids for CAPNS2
      Search eBioscience for proteins for CAPNS2
      Search eBioscience for elisas for CAPNS2
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for CAPNS2 (13 products)
     antibodies-online kits for CAPNS2 (2 products)
     antibodies-online peptides for CAPNS2
     antibodies-online proteins for CAPNS2 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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