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Aliases for CAPNS2 Gene

Aliases for CAPNS2 Gene

  • Calpain Small Subunit 2 2 3 5
  • Calcium-Dependent Protease Small Subunit 2 3 4
  • CSS2 3 4

External Ids for CAPNS2 Gene

Previous GeneCards Identifiers for CAPNS2 Gene

  • GC16P046015
  • GC16P055338
  • GC16P055379
  • GC16P054158

Summaries for CAPNS2 Gene

GeneCards Summary for CAPNS2 Gene

CAPNS2 (Calpain Small Subunit 2) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Neurodegenerative Diseases. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPNS1.

UniProtKB/Swiss-Prot for CAPNS2 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.

Tocris Summary for CAPNS2 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPNS2 Gene

Genomics for CAPNS2 Gene

Regulatory Elements for CAPNS2 Gene

Enhancers for CAPNS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G055470 1.4 Ensembl ENCODE dbSUPER 10.1 -95.0 -94999 2.7 ELF3 FOXA2 ARID4B RARA ZNF121 ZNF766 GATA2 FOS EGR2 HMG20B MMP2-AS1 LPCAT2 CAPNS2 GC16P055480 GC16P055479
GH16G055623 1 ENCODE 11.1 +56.8 56772 0.3 FOXA2 MLX ARID4B DMAP1 SLC30A9 ZNF766 ZNF143 FOS SP5 ZHX2 CAPNS2 MMP2 SLC6A2
GH16G055667 0.8 ENCODE 10.4 +101.7 101726 1.7 CTCF KLF1 NFIB JUN ZMYM3 ZNF48 ZIC2 RAD21 SMC3 FOS SLC6A2 CAPNS2 MMP2 LPCAT2 ENSG00000278928
GH16G055484 1.2 FANTOM5 ENCODE dbSUPER 5.6 -79.8 -79786 4.4 JUND BHLHE40 ZSCAN4 ZNF26 SIN3A KDM1A FOS MYC NFE2L2 LPCAT2 CAPNS2 SLC6A2 MMP2 GC16M055484
GH16G055665 0.6 ENCODE 10.6 +98.5 98532 0.2 SOX5 SOX13 TBX3 TEAD1 PPARG RXRB TEAD3 MMP2 CAPNS2 LPCAT2 SLC6A2 ENSG00000278928
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAPNS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPNS2 Gene

Chromosome:
16
Start:
55,566,672 bp from pter
End:
55,567,687 bp from pter
Size:
1,016 bases
Orientation:
Plus strand

Genomic View for CAPNS2 Gene

Genes around CAPNS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPNS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPNS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPNS2 Gene

Proteins for CAPNS2 Gene

  • Protein details for CAPNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L46-CPNS2_HUMAN
    Recommended name:
    Calpain small subunit 2
    Protein Accession:
    Q96L46
    Secondary Accessions:
    • Q9BPV4

    Protein attributes for CAPNS2 Gene

    Size:
    248 amino acids
    Molecular mass:
    27660 Da
    Quaternary structure:
    • Heterodimer of a large (catalytic) and a small (regulatory) subunit.

neXtProt entry for CAPNS2 Gene

Post-translational modifications for CAPNS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPNS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAPNS2 Gene

Domains & Families for CAPNS2 Gene

Gene Families for CAPNS2 Gene

Protein Domains for CAPNS2 Gene

Suggested Antigen Peptide Sequences for CAPNS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CAPNS2: view

No data available for UniProtKB/Swiss-Prot for CAPNS2 Gene

Function for CAPNS2 Gene

Molecular function for CAPNS2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.

Gene Ontology (GO) - Molecular Function for CAPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CAPNS2: view

Phenotypes for CAPNS2 Gene

genes like me logo Genes that share phenotypes with CAPNS2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAPNS2 Gene

Localization for CAPNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPNS2 Gene

Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPNS2 gene
Compartment Confidence
plasma membrane 4
cytosol 4

Gene Ontology (GO) - Cellular Components for CAPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CAPNS2: view

Pathways & Interactions for CAPNS2 Gene

genes like me logo Genes that share pathways with CAPNS2: view

Gene Ontology (GO) - Biological Process for CAPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with CAPNS2: view

No data available for SIGNOR curated interactions for CAPNS2 Gene

Drugs & Compounds for CAPNS2 Gene

(5) Drugs for CAPNS2 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Epoxomicin Pharma Proteasome inhibitor 0
MG-132 Pharma Proteasome inhibitor, Cell permeable, reversible 0
PSI Pharma Proteasome inhibitor 0
calcium Nutra 0
Acetyl-Calpastatin (184-210) (human) Pharma Calpain I/II inhibitor, Selective calpain inhibitor 0

(1) Additional Compounds for CAPNS2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 132
133407-82-6

(2) Tocris Compounds for CAPNS2 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6

(3) ApexBio Compounds for CAPNS2 Gene

Compound Action Cas Number
Epoxomicin Proteasome inhibitor 134381-21-8
MG-132 Proteasome inhibitor, Cell permeable, reversible 133407-82-6
PSI Proteasome inhibitor 158442-41-2
genes like me logo Genes that share compounds with CAPNS2: view

Drug Products

Transcripts for CAPNS2 Gene

mRNA/cDNA for CAPNS2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(135) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAPNS2 Gene

Calpain, small subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPNS2 Gene

No ASD Table

Relevant External Links for CAPNS2 Gene

GeneLoc Exon Structure for
CAPNS2
ECgene alternative splicing isoforms for
CAPNS2

Expression for CAPNS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPNS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPNS2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x14.0), Skin - Sun Exposed (Lower leg) (x12.8), Esophagus - Mucosa (x12.5), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for CAPNS2 Gene

This gene is overexpressed in Hair follicle (47.5) and Cervix (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAPNS2 Gene



Protein tissue co-expression partners for CAPNS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPNS2 Gene:

CAPNS2

SOURCE GeneReport for Unigene cluster for CAPNS2 Gene:

Hs.660027
genes like me logo Genes that share expression patterns with CAPNS2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPNS2 Gene

Orthologs for CAPNS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPNS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPNS2 34
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia CAPNS2 34
  • 87.67 (n)
dog
(Canis familiaris)
Mammalia CAPNS2 34
  • 87.5 (n)
mouse
(Mus musculus)
Mammalia Capns2 34 16 35
  • 86.1 (n)
rat
(Rattus norvegicus)
Mammalia Capns2 34
  • 85.29 (n)
chicken
(Gallus gallus)
Aves CAPNS2 34
  • 71.12 (n)
zebrafish
(Danio rerio)
Actinopterygii capns1a 35
  • 60 (a)
ManyToMany
capns1b 35
  • 60 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012067 34
  • 50.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4609 35
  • 11 (a)
OneToMany
Species where no ortholog for CAPNS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPNS2 Gene

ENSEMBL:
Gene Tree for CAPNS2 (if available)
TreeFam:
Gene Tree for CAPNS2 (if available)

Paralogs for CAPNS2 Gene

Paralogs for CAPNS2 Gene

(10) SIMAP similar genes for CAPNS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CAPNS2: view

Variants for CAPNS2 Gene

Sequence variations from dbSNP and Humsavar for CAPNS2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1001906948 -- 55,567,961(+) GTTTT(C/T)CTTGT intron-variant
rs1004190041 -- 55,567,540(+) GAGGA(C/T)AGGAC intron-variant, utr-variant-3-prime
rs1005039568 -- 55,565,853(+) ATTTT(A/T)TGGCA intron-variant, upstream-variant-2KB
rs1006044092 -- 55,567,521(+) GAAGT(C/T)AAGAT intron-variant, utr-variant-3-prime
rs1008988575 -- 55,565,361(+) GTATA(C/T)ACCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAPNS2 Gene

Variant ID Type Subtype PubMed ID
dgv2984n100 CNV loss 25217958
nsv1062908 CNV loss 25217958
nsv521337 CNV loss 19592680

Variation tolerance for CAPNS2 Gene

Residual Variation Intolerance Score: 65.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPNS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPNS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPNS2 Gene

Disorders for CAPNS2 Gene

Relevant External Links for CAPNS2

Genetic Association Database (GAD)
CAPNS2
Human Genome Epidemiology (HuGE) Navigator
CAPNS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPNS2

No disorders were found for CAPNS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPNS2 Gene

Publications for CAPNS2 Gene

  1. A novel human small subunit of calpains. (PMID: 11853546) Schad E. … Friedrich P. (Biochem. J. 2002) 2 3 4 22 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Expression of calpain small subunit 2 in mammalian tissues. (PMID: 15590481) Ma H. … Shearer T.R. (Curr. Eye Res. 2004) 3 22 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CAPNS2 Gene

Sources for CAPNS2 Gene

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