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Aliases for CAPNS1 Gene

Aliases for CAPNS1 Gene

  • Calpain, Small Subunit 1 2 3
  • CAPN4 3 4 6
  • Calcium-Activated Neutral Proteinase Small Subunit 3 4
  • Calcium-Dependent Protease Small Subunit 1 3 4
  • Calpain Regulatory Subunit 3 4
  • CANP Small Subunit 3 4
  • CDPS 3 4
  • CSS1 3 4
  • Calcium-Dependent Protease, Small Subunit 3
  • Calcium-Dependent Protease Small Subunit 4
  • Calpain 4, Small Subunit (30K) 3
  • Calpain, Small Polypeptide 3
  • Calpain Small Subunit 1 3
  • CALPAIN4 3
  • CANPS 3
  • CAPNS 4
  • CANP 3

External Ids for CAPNS1 Gene

Previous HGNC Symbols for CAPNS1 Gene

  • CAPN4

Previous GeneCards Identifiers for CAPNS1 Gene

  • GC19P037270
  • GC19P037079
  • GC19P041306
  • GC19P041322
  • GC19P036630
  • GC19P033136

Summaries for CAPNS1 Gene

Entrez Gene Summary for CAPNS1 Gene

  • This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for CAPNS1 Gene

CAPNS1 (Calpain, Small Subunit 1) is a Protein Coding gene. Diseases associated with CAPNS1 include chronic neutrophilic leukemia. Among its related pathways are ERK Signaling and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPNS1 Gene

  • Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction

Tocris Summary for CAPNS1 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

Gene Wiki entry for CAPNS1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPNS1 Gene

Genomics for CAPNS1 Gene

Regulatory Elements for CAPNS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAPNS1 Gene

36,139,575 bp from pter
36,150,353 bp from pter
10,779 bases
Plus strand

Genomic View for CAPNS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPNS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPNS1 Gene

Proteins for CAPNS1 Gene

  • Protein details for CAPNS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calpain small subunit 1
    Protein Accession:
    Secondary Accessions:
    • A8K0P1
    • Q8WTX3
    • Q96EW0

    Protein attributes for CAPNS1 Gene

    268 amino acids
    Molecular mass:
    28316 Da
    Quaternary structure:
    • Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates (By similarity).

    Three dimensional structures from OCA and Proteopedia for CAPNS1 Gene

neXtProt entry for CAPNS1 Gene

Proteomics data for CAPNS1 Gene at MOPED

Post-translational modifications for CAPNS1 Gene

  • Ubiquitination at Lys172 and Lys179
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CAPNS1 Gene

Domains for CAPNS1 Gene

Gene Families for CAPNS1 Gene

  • EFHAND :EF-hand domain containing

Protein Domains for CAPNS1 Gene

Suggested Antigen Peptide Sequences for CAPNS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P04632
  • The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer.
  • EF-hand domains are paired. EF-hand 1 is paired with EF-hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF-hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant
  • Contains 5 EF-hand domains.
genes like me logo Genes that share domains with CAPNS1: view

Function for CAPNS1 Gene

Molecular function for CAPNS1 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction

Gene Ontology (GO) - Molecular Function for CAPNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 10639123
genes like me logo Genes that share ontologies with CAPNS1: view
genes like me logo Genes that share phenotypes with CAPNS1: view

Animal Models for CAPNS1 Gene

MGI Knock Outs for CAPNS1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CAPNS1 Gene

Localization for CAPNS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPNS1 Gene

Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CAPNS1 Gene COMPARTMENTS Subcellular localization image for CAPNS1 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAPNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA 14559243
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 14559243
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CAPNS1: view

Pathways for CAPNS1 Gene

genes like me logo Genes that share pathways with CAPNS1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CAPNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
GO:0008284 positive regulation of cell proliferation TAS 8702541
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with CAPNS1: view

Compounds for CAPNS1 Gene

(4) Tocris Compounds for CAPNS1 Gene

Compound Action Cas Number
MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
MG 101 Calpain inhibitor; activates p53-dependent apoptosis [110044-82-1]
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation [133407-82-6]
PD 150606 Cell permeable calpain inhibitor [179528-45-1]

(1) HMDB Compounds for CAPNS1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Drugbank Compounds for CAPNS1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs

(5) Novoseek inferred chemical compound relationships for CAPNS1 Gene

Compound -log(P) Hits PubMed IDs
calpeptin 76.5 1
leupeptin 51.8 1
cysteine 30.5 3
calcium 29 11
serine 0 2
genes like me logo Genes that share compounds with CAPNS1: view

Transcripts for CAPNS1 Gene

Unigene Clusters for CAPNS1 Gene

Calpain, small subunit 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPNS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPNS1 Gene

No ASD Table

Relevant External Links for CAPNS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPNS1 Gene

mRNA expression in normal human tissues for CAPNS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPNS1 Gene

SOURCE GeneReport for Unigene cluster for CAPNS1 Gene Hs.515371

genes like me logo Genes that share expressions with CAPNS1: view

Expression partners for CAPNS1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAPNS1 Gene

Orthologs for CAPNS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAPNS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAPNS1 35
  • 91.67 (n)
  • 96.7 (a)
  • 97 (a)
(Canis familiaris)
Mammalia CAPNS1 35
  • 87.31 (n)
  • 93.28 (a)
  • 96 (a)
(Mus musculus)
Mammalia Capns1 35
  • 84.45 (n)
  • 90.67 (a)
Capns1 16
Capns1 36
  • 95 (a)
(Pan troglodytes)
Mammalia CAPNS1 35
  • 99.36 (n)
  • 100 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Capns1 35
  • 83.58 (n)
  • 88.81 (a)
(Monodelphis domestica)
Mammalia CAPNS1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia CAPNS1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia CAPNS1 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia capns2 35
  • 71.96 (n)
  • 77.4 (a)
Str.273 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23845 35
(Danio rerio)
Actinopterygii capns1 35
capns1a 35
  • 67.62 (n)
  • 68.9 (a)
capns1a 36
  • 68 (a)
capns1b 36
  • 66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9382 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4609 36
  • 11 (a)
Species with no ortholog for CAPNS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPNS1 Gene

Gene Tree for CAPNS1 (if available)
Gene Tree for CAPNS1 (if available)

Paralogs for CAPNS1 Gene Pseudogenes for CAPNS1 Gene

genes like me logo Genes that share paralogs with CAPNS1: view

Variants for CAPNS1 Gene

Sequence variations from dbSNP and Humsavar for CAPNS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs14100 -- 36,149,867(+) CTCAC(C/T)GCCTT utr-variant-3-prime
rs1049339 -- 36,149,862(+) GCCCC(C/T)TCACC utr-variant-3-prime
rs1049643 -- 36,150,172(+) GCCCT(C/T)TCTCA utr-variant-3-prime
rs1049657 -- 36,150,181(+) CAGTT(C/T)TGGGA utr-variant-3-prime
rs1049720 -- 36,150,296(+) ATATT(C/T)TGCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CAPNS1 Gene

Variant ID Type Subtype PubMed ID
dgv3854n71 CNV Loss 21882294
dgv3855n71 CNV Loss 21882294

Relevant External Links for CAPNS1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPNS1 Gene

Disorders for CAPNS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CAPNS1 Gene in MalaCards »

(1) Diseases for CAPNS1 Gene including...

(3) Novoseek inferred disease relationships for CAPNS1 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 38.4 1
tumors 2.58 3
leukemia 0 1

Relevant External Links for CAPNS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CAPNS1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CAPNS1 Gene

Publications for CAPNS1 Gene

  1. Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease. (PMID: 3016651) Ohno S. … Suzuki K. (Nucleic Acids Res. 1986) 2 3 4
  2. Gene organization of the small subunit of human calcium-activated neutral protease. (PMID: 3024120) Miyake S. … Suzuki K. (Nucleic Acids Res. 1986) 2 3 4
  3. An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. (PMID: 19942621) Fairfax B.P. … Knight J.C. (Hum. Mol. Genet. 2010) 3 23
  4. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. (PMID: 20419804) Zhang F. … Zhang X. (J. Med. Virol. 2010) 3 23
  5. The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells. (PMID: 8702541) Zhang W. … Mellgren R.L. (J. Biol. Chem. 1996) 3 23

Products for CAPNS1 Gene

Sources for CAPNS1 Gene

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