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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPN9 Gene

protein-coding   GIFtS: 60
GCID: GC01P230883

calpain 9

(Previous name: calpain 9 (nCL-4) )
 Explore 9 diseases affiliated with
CAPN9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CAPN9    

Aliases
for CAPN9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calpain 91 2     Novel Calpain Large Subunit-42
NCL-41     EC 3.4.22.-3
GC361 2     NCL43
Digestive Tract-Specific Calpain2 3     Protein CG363
New Calpain 42 3     EC 3.4.228
Calpain 9 (NCL-4)1     EC 3.4.22.548
Calpain-91     

External Ids:    HGNC: 14861   Entrez Gene: 107532   Ensembl: ENSG000001357737   OMIM: 6064015   UniProtKB: O148153   

Export aliases for CAPN9 gene to outside databases

Previous GC identifers: GC01P229360 GC01P226611 GC01P227356 GC01P227918 GC01P227189 GC01P228949 GC01P201367


Summaries
for CAPN9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CAPN9:
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are
heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a
cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in
neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein
encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in
the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAN9_HUMAN, O14815
Function: Calcium-regulated non-lysosomal thiol-protease

summary for CAPN9:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

Gene Wiki entry for CAPN9


Genomic Views
for CAPN9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPN9 gene promoter:
         PPAR-gamma1   AML1a   deltaCREB   PPAR-gamma2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAPN9 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPN9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.11-q42.3   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.11-q42.3

CAPN9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P230883:  view genomic region     (about GC identifiers)

Start:
 230,883,130 bp from pter      End:
 230,937,749 bp from pter
Size:
 54,620 bases      Orientation:
 plus strand

Proteins
for CAPN9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CAN9_HUMAN, O14815 (See protein sequence)
Recommended Name: Calpain-9  
Size: 690 amino acids; 79097 Da
2 PDB 3D structures from and Proteopedia for CAPN9:
1ZIV (3D)        2P0R (3D)    
Secondary accessions: B1APS1 B1AQI0 Q9NS74
Alternative splicing: 2 isoforms:  O14815-1   O14815-2   

Explore the universe of human proteins at neXtProt for CAPN9: NX_O14815

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14815

    • 4/14 DME Specific Peptides for CAPN9 (O14815) (see all 14)
     YAGIFHF  FINLREV  RTDICQG  GATRTDI 

    CAPN9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_006606.1  NP_057536.1  

    ENSEMBL proteins: 
     ENSP00000271971   ENSP00000346538   ENSP00000355626  

    Human Recombinant Protein Products: 
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    Novus Biologicals CAPN9 Protein
    Novus Biologicals CAPN9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CAPN9

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular IEA--


    CAPN9 for ontologies           About GeneDecksing



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    Uscn Antibodies for CAPN9
    ThermoFisher Antibodies for CAPN9

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    Uscn ELISAs and CLIAs for CAPN9

    Protein Domains /
    Families
    for CAPN9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CAPN9 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR001300 Peptidase_C2_calpain_cat
     IPR018247 EF_Hand_1_Ca_BS
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry O14815

    ProtoNet protein and cluster: O14815

    1 Blocks protein family: IPB001300 Calpain cysteine protease (C2) family signature

    UniProtKB/Swiss-Prot: CAN9_HUMAN, O14815
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 3 EF-hand domains


    Function
    for CAPN9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CAN9_HUMAN, O14815
    Function: Calcium-regulated non-lysosomal thiol-protease
    Catalytic activity: Broad endopeptidase specificity
    Induction: Down-regulated in gastric cancer tissue and in gastric cell lines of differentiated and poorly
    differentiated types

    Enzyme Numbers (IUBMB): EC 3.4.22.542 EC 3.4.222 EC 3.4.22.-1

    miRNA
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    hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CAPN9 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--


    CAPN9 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CAPN9:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Capn9tm1Hiso for CAPN9
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Capn9):
     digestive/alimentary  homeostasis/metabolism 

    CAPN9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CAPN9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1DREAM Repression and Dynorphin Expression
    		nNOS Signaling in Skeletal Muscle0.37
    		Calpain Protease Regulates Cellular Mechanics0.22
    		Caspase Cascade0.24
    2Apoptosis Pathway
    		Apoptosis Pathway1.00
    3Integrin Pathway
    		FAK1 Signaling0.67
    4Rho Family GTPases
    		ERK Signaling0.61
    5Focal Adhesion
    		Integrin-mediated cell adhesion0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAPN9
        Caspase Cascade
    ERK Signaling
    Calpain Protease Regulates Cellular Mechanics
    FAK1 Signaling
    nNOS Signaling in Skeletal Muscle

    1 Tocris Bioscience Pathway for CAPN9
        Apoptosis Pathway

    1 BioSystems Pathway for CAPN9 
        Integrin-mediated cell adhesion


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAPN9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CAPN9 (ENSP000002719714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHBGENSP000003698164STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007586digestion TAS9524069


    CAPN9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CAPN9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAPN9 for compounds           About GeneDecksing

    EMD Millipore small molecules for CAPN9:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CAPN9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CalpeptinCalpain and cathepsin L inhibitor[117591-20-5]
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPN9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for CAPN9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 8.92 9 9917325 (1)

    Search CenterWatch for drugs/clinical trials and news about CAPN9 / CAN9 

    Transcripts
    for CAPN9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CAPN9 gene (2 alternative transcripts): 
    NM_006615.2  NM_016452.1  

    Unigene Cluster for CAPN9:

    Calpain 9
    Hs.498021  [show with all ESTs]
    Unigene Representative Sequence: AB038463
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000271971 ENST00000354537(uc001htz.1 uc001hua.1 uc009xfg.1)
    ENST00000480004 ENST00000366666

    miRNA
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    hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CAPN9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPN9 (see all 4)
    OriGene shRNA RFP: CAPN9
    OriGene siRNA: CAPN9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN9
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CAPN9 (NM_006615)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN9 
    Primer
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    Additional cDNA sequence: 

    AB038463.1 AF022799.1 AK298024.1 AK309039.1 AK313629.1 BC027993.1 

    6 DOTS entries:

    DT.95157981  DT.75139514  DT.97775099  DT.40122120  DT.121461251  DT.320301 

    17 AceView cDNA sequences:

    BC027993 NM_006615 AA330385 AF022799 AB038463 BI523925 BX956884 AI733427 
    BM747642 CD692048 AI074272 BI818092 BI524673 BM987591 CF139910 BM749637 
    AI870462 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN9 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
    SP1:                    -                                               -                                                                       -               
    SP2:                    -                                         -     -                                                                       -               
    SP3:                    -     -     -                                   -                                                                       -               
    SP4:                                                                                                              -                                             
    SP5:                                                                                                                                            -           -   

    ExUns: 21a · 21b · 21c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CAPN9

    Expression
    for CAPN9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPN9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTACCTATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CAPN9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CAPN9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPN9

    SOURCE GeneReport for Unigene cluster: Hs.498021

    UniProtKB/Swiss-Prot: CAN9_HUMAN, O14815
    Tissue specificity: Expressed predominantly in stomach

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN9

    Orthologs
    for CAPN9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAPN9 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CAPN91 calpain 9 75.75(n)
    79.28(a)    		   421544  XM_419585.3  XP_419585.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CAPN96
    		 --
    		 77(a)
    		 1 ↔ 1
    		 1(222849579-222886085)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.24592 Transcribed sequence with moderate similarity to protein more 72.63(n)    CF224666.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii capn92 calpain 9 75.69(n)   114400  CK015810.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CalpA1 , 3 actin cytoskeleton organization and
    biogenesis more3
    Calpain-A1    		 51(a)
    (best of 3)3
    54.05(n)1
    49.39(a)1    		   56D53
    372321  NM_057699.41  NP_477047.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea clp-73   -- 47(a)
    (best of 3)    		   IV(1435632-1445971)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATDEK16
    		 calpain-type cysteine protease
    		 6(a)
    		 1 → many
    		 1(20653820-20665095)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 calpain, putative, expressed
    		 6(a)
    		 1 → many
    		 2(29335385-29352022)


    ENSEMBL Gene Tree for CAPN9 (if available)
    TreeFam Gene Tree for CAPN9 (if available) 

    Paralogs
    for CAPN9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAPN9 gene
    CAPN62  CAPN82  CAPN142  CAPN132  CAPN52  CAPN12  CAPN32  CAPN22  
    CAPN72  CAPN122  SOLH2  CAPN112  CAPN102  
    14 SIMAP similar genes for CAPN9 using alignment to 3 protein entries:     CAN9_HUMAN (see all proteins):
    CAPN1    CAPN2    CAPNS1    CAPN11    CAPNS2    CAPN3
    CAPN8    CAPN14    CAPN12    CAPN5    SRI    CAPN6
    CAPN13    GCA

    CAPN9 for paralogs           About GeneDecksing



    Genomic Variants
    for CAPN9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1409 NCBI SNPs in CAPN9 are shown (see all 1409)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1905886461,2
    		--230881174(+) GAAAAC/TTGGGA 2 -- us2k10--------
    rs802469361,2
    		C,F,--230881330(+) TTTCTG/TGTTCC 2 -- us2k15Minor allele frequency- T:0.08NA CSA WA EA 362
    rs1830828061,2
    		--230881350(+) ACATGA/GTGGAA 2 -- us2k10--------
    rs583458861,2
    		C,--230881417(+) GAGGGC/TTCCAC 2 -- us2k14Minor allele frequency- T:0.12WA NA EA 360
    rs727606271,2
    		C,F,--230881422(+) CTCCAC/TTCTTC 2 -- us2k11Minor allele frequency- T:0.07NA 120
    rs283595651,2
    		C,F,--230881492(+) TTCAAC/AATACA 2 -- us2k112Minor allele frequency- A:0.15NS NA WA EA 1080
    rs283595661,2
    		C,F,--230881512(+) GGGGTC/G/TGGGGG 2 -- us2k14NS WA NA 186
    rs2013265421,2
    		--230881512(+) GGGGT-/CGGGGG 2 -- us2k10--------
    rs283595681,2
    		C,--230881526(+) GGTGCG/AGAATA 2 -- us2k11Minor allele frequency- A:0.01NS 180
    rs168525351,2
    		C,F,H,--230881658(+) CCTGGG/AAACTG 2 -- us2k130Minor allele frequency- A:0.36NA NS EA WA CSA 2182

    HapMap Linkage Disequilibrium report for CAPN9 (230883130 - 230937749 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CAPN9: --

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    DNA2.0 Custom Variant and Variant Library Synthesis for CAPN9

    Disorders / Diseases
    for CAPN9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CAPN9 for disorders           About GeneDecksing

    OMIM gene information: 606401    OMIM disorders: --

    9 diseases for CAPN9:    About MalaCards
    muscular dystrophy    gastric cancer    alzheimer's disease    chronic lymphocytic leukemia
    lymphocytic leukemia    leukemia    esophagitis    adenocarcinoma
    neuronitis

    2 Novoseek disease relationships for CAPN9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 51.2 4 11516996 (1), 10835488 (1), 17157313 (1)
    alzheimers disease 28 1 17157313 (1)

    Human Genome Epidemiology (HuGE) Navigator: CAPN9 (4 documents)

    Export disorders for CAPN9 gene to outside databases

    Publications
    for CAPN9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPN9 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CAPN9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of two novel genes, down-regulated in gastric cancer. (PubMed id 10835488)1, 2, 3, 9 Yoshikawa Y.... Kato I. (2000)
    2. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. (PubMed id 9524069)1, 2, 3 Lee H.-J.... Suzuki K. (1998)
    3. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. (PubMed id 17157313)1, 2, 9 Davis T.L....Dhe-Paganon S. (2007)
    4. Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system. (PubMed id 9917325)1, 9 Lee H.J....Suzuki K. (1999)
    5. The calpain family and human disease. (PubMed id 11516996)1, 9 Huang Y. and Wang K.K. (2001)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1 Liu C.Y....Christiani D.C. (2010)
    8. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1 Enjuanes A....Campo E. (2008)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for CAPN9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CAPN9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10753 HGNC: 1486 AceView: CAPN9 Ensembl:ENSG00000135773 euGenes: HUgn10753
    ECgene: CAPN9 H-InvDB: CAPN9

    Other Databases showing CAPN9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CAPN9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPN9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAPN9 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/capn9/

    Intellectual Property
    for CAPN9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CAPN9 gene:
    Search GeneIP for patents involving CAPN9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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