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CAPN8 Gene

protein-coding   GIFtS: 45
GCID: GC01M223711

Calpain 8

(Previous name: calpain 8 (nCL-2))
  Search for CAPN8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calpain 81 2     Calpain 8 (NCL-2)1
New Calpain 22 3     calpain-82
Stomach-Specific M-Type Calpain2 3     NCL23
nCL-22 3     EC 3.4.228
EC 3.4.22.533 8     

External Ids:    HGNC: 14851   Entrez Gene: 3887432   Ensembl: ENSG000002036977   UniProtKB: A6NHC03   

Export aliases for CAPN8 gene to outside databases

Previous GC identifers: GC02U990107 GC01U901168 GC01M221871 GC01M221782 GC01M194391


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CAPN8 Gene:
CAPN8 (calpain 8) is a protein-coding gene. GO annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is CAPN6.

UniProtKB/Swiss-Prot: CAN8_HUMAN, A6NHC0
Function: Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface
mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat
protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity)

summary for CAPN8 Gene:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAPN8 gene promoter:
         Tal-1   AP-1   Tal-1beta   E47   POU2F1   COMP1   POU2F1a   LyF-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CAPN8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPN8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

CAPN8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M223711:  view genomic region     (about GC identifiers)

Start:
223,711,349 bp from pter      End:
223,853,436 bp from pter
Size:
142,088 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAN8_HUMAN, A6NHC0 (See protein sequence)
Recommended Name: Calpain-8  
Size: 703 amino acids; 79144 Da
Cofactor: Binds 2 calcium ions (Potential)
Subunit: Monomer and homooligomer. Interacts with COPS1/GPS1, COPB1, EYA2, NME2, NME4 and TOMM70A (By similarity)
Secondary accessions: B2RXL2

Explore the universe of human proteins at neXtProt for CAPN8: NX_A6NHC0

Explore proteomics data for CAPN8 at MOPED

Post-translational modifications: 

  • Undergoes autolytic cleavage between Ala-5 and Ala-6 which gives rise to fragments extending from Ala-6 to the
    C-terminus, Ala-6 to the EF-hand 2 domain and from Ala-6 to the beginning of domain III (By similarity)1
  • Modification sites at neXtProt
  • Selected DME Specific Peptides for CAPN8 (A6NHC0) (see all 13)
     RLRNPWG  YAGIFHF  RTDICQG  GATRTDI 


    See CAPN8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001137434.1  
    ENSEMBL proteins: 
     ENSP00000436371   ENSP00000409233   ENSP00000390294   ENSP00000401665   ENSP00000355838  
     ENSP00000434013   ENSP00000435953   ENSP00000355837  

    CAPN8 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CAPN8

     
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    LSBio Antibodies in human, mouse, rat for CAPN8

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    Search eBioscience for ELISAs for CAPN8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 8):
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR001300 Peptidase_C2_calpain_cat
     IPR018247 EF_Hand_1_Ca_BS
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry A6NHC0

    ProtoNet protein and cluster: A6NHC0

    UniProtKB/Swiss-Prot: CAN8_HUMAN, A6NHC0
    Domain: The domain III mediates oligomerization (By similarity)
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 3 EF-hand domains


    Find genes that share domains with CAPN8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAN8_HUMAN, A6NHC0
    Function: Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface
    mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat
    protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity)
    Catalytic activity: Broad endopeptidase specificity

         Enzyme Numbers (IUBMB): EC 3.4.22.531 2 EC 3.4.222

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IBA--
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with CAPN8           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Capn8):
     digestive/alimentary  homeostasis/metabolism 

    Find genes that share phenotypes with CAPN8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Capn8tm1Hiso for CAPN8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPN8
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    hsa-miR-1207-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAN8_HUMAN, A6NHC0: Cytoplasm (By similarity). Golgi apparatus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    golgi apparatus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0005794Golgi apparatus IEA--

    Find genes that share ontologies with CAPN8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAPN8 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis Pathway
    Apoptosis Pathway0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Tocris Bioscience Pathway for CAPN8
        Apoptosis Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAPN8
    Interactions:

        Search GeneGlobe Interaction Network for CAPN8

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IBA--

    Find genes that share ontologies with CAPN8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    9 ApexBio Compounds for CAPN8     About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    Calpain Inhibitor I, ALLNA cell-permeable inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L. [110044-82-1]
    Calpain Inhibitor II, ALLMA cell-permeable inhibitor of calpain 1 and calpain 2[136632-32-1]
    CalpeptinPotent, cell-permeable inhibitor of calpain[117591-20-5]
    E-64Irriversible cysteine protease inhibitor[66701-25-5]
    MDL 28170Potent, selective inhibitor of calpain and cathepsin B[88191-84-8]
    MG-132Proteasome and calpain inhibitor[133407-82-6]
    PD 150606Selective, cell-permeable non-peptide calpain inhibitor[179528-45-1]
    Z-FA-FMKAn inhibitor of cysteine proteases, such as cathepsin B--

    Compounds for CAPN8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    PD 150606Cell permeable calpain inhibitor[179528-45-1]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPN8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAPN8 gene: 
    NM_001143962.1  

    Unigene Cluster for CAPN8:

    Calpain 8
    Hs.291487  [show with all ESTs]
    Unigene Representative Sequence: NM_001143962
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484873 ENST00000442247 ENST00000430824 ENST00000482401 ENST00000482183
    ENST00000419193 ENST00000366873 ENST00000467384 ENST00000465098 ENST00000525760
    ENST00000366872(uc009xee.2)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CAPN8:
    hsa-miR-1207-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CAPN8
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      QuantiTect SYBR Green Assays in human, mouse, rat CAPN8
      QuantiFast Probe-based Assays in human, mouse, rat CAPN8

    Additional mRNA sequence: BC157893.1 

    9 DOTS entries:

    DT.92417858  DT.206669  DT.97835005  DT.95264161  DT.70104332  DT.75128792  DT.121339980  DT.86845546 
    DT.86858095 

    3 AceView cDNA sequences:

    BM825948 BM759585 BM839499 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAPN8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCAGCTCT
    CAPN8 Expression
    About this image

    CAPN8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPN8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.291487

    UniProtKB/Swiss-Prot: CAN8_HUMAN, A6NHC0
    Tissue specificity: Stomach

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CAPN8 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capn81 , 5 calpain 81, 5 83.78(n)1
    83.21(a)1
      1 (85.37 cM)5
    1707251  NM_130890.21  NP_570960.21 
     1825650075 
    chicken
    (Gallus gallus)
    Aves CAPN81 calpain 8 72.46(n)
    71.94(a)
      428561  XM_426117.3  XP_426117.2 
    lizard
    (Anolis carolinensis)
    Reptilia CAPN86
    calpain 8
    58(a)
    1 ↔ 1
    1(244998004-245048613)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia capn81 calpain 8 67.14(n)
    65.95(a)
      733929  NM_001045643.1  NP_001039108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii capn81 calpain 8 61.23(n)
    56.65(a)
      337730  NM_001244080.1  NP_001231009.1 
    worm
    (Caenorhabditis elegans)
    Secernentea clp-11 clp-1 53.86(n)
    51.8(a)
      176122  NM_066339.5  NP_498740.2 


    ENSEMBL Gene Tree for CAPN8 (if available)
    TreeFam Gene Tree for CAPN8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAPN8 gene
    CAPN62  CAPN142  CAPNS12  CAPN132  CAPN12  CAPN52  CAPN92  CAPN32  
    CAPNS22  CAPN22  CAPN122  CAPN112  CAPN102  
    15 SIMAP similar genes for CAPN8 using alignment to 8 protein entries:     CAN8_HUMAN (see all proteins):
    CAPN2    CAPN1    CAPN11    CAPNS2    CAPN12    CAPN3
    CAPN9    CAPN14    CAPNS1    CAPN13    CAPN5    SRI
    GCA    CAPN6    CAPN10

    Find genes that share paralogs with CAPN8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CAPN8 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723417CNV Deletion23290073
    esv2723495CNV Deletion23290073
    nsv821216CNV Deletion20802225
    dgv60e201CNV Deletion23290073
    esv2740896CNV Deletion23290073
    dgv62e201CNV Deletion23290073
    esv1919956CNV Deletion18987734
    esv2723473CNV Deletion23290073
    esv2741351CNV Deletion23290073
    dgv59e201CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CAPN8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for CAPN8:
    Neuronal ceroid lipofuscinosis

    Find genes that share disorders with CAPN8           About GenesLikeMe

    Genetic Association Database (GAD): CAPN8

    Export disorders for CAPN8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAPN8 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with CAPN8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution. (PubMed id 11523006)1, 2 Hata S.... Suzuki K. (J. Mol. Evol. 2001)
    2. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1, 3 Hillier L.D....Marra M. (Genome Res. 1996)
    3. A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain. (PubMed id 7690035)1, 3 Sorimachi H....Suzuki K. (J. Biol. Chem. 1993)
    4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    5. Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains. (PubMed id 17646163)1 Hata S....Sorimachi H. (J. Biol. Chem. 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 388743 HGNC: 1485 AceView: LOC388743 Ensembl:ENSG00000203697 euGenes: HUgn388743
    ECgene: CAPN8 H-InvDB: CAPN8

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CAPN8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CAPN8 gene:
    Search GeneIP for patents involving CAPN8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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