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Aliases for CAPN8 Gene

Aliases for CAPN8 Gene

  • Calpain 8 2 3 5
  • Stomach-Specific M-Type Calpain 3 4
  • New Calpain 2 3 4
  • EC 3.4.22.53 4 63
  • NCL-2 3 4
  • Calpain 8 (NCL-2) 2
  • EC 3.4.22 63
  • NCL2 4

External Ids for CAPN8 Gene

Previous GeneCards Identifiers for CAPN8 Gene

  • GC02U990107
  • GC01U901168
  • GC01M221871
  • GC01M221782
  • GC01M223711
  • GC01M194391

Summaries for CAPN8 Gene

GeneCards Summary for CAPN8 Gene

CAPN8 (Calpain 8) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Apoptosis Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN8 Gene

  • Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).

Tocris Summary for CAPN8 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN8 Gene

Genomics for CAPN8 Gene

Regulatory Elements for CAPN8 Gene

Genomic Location for CAPN8 Gene

Chromosome:
1
Start:
223,538,007 bp from pter
End:
223,665,734 bp from pter
Size:
127,728 bases
Orientation:
Minus strand

Genomic View for CAPN8 Gene

Genes around CAPN8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN8 Gene

Proteins for CAPN8 Gene

  • Protein details for CAPN8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHC0-CAN8_HUMAN
    Recommended name:
    Calpain-8
    Protein Accession:
    A6NHC0
    Secondary Accessions:
    • B2RXL2

    Protein attributes for CAPN8 Gene

    Size:
    703 amino acids
    Molecular mass:
    79144 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Monomer and homooligomer. Interacts with COPS1/GPS1, COPB1, EYA2, NME2, NME4 and TOMM70A (By similarity).

neXtProt entry for CAPN8 Gene

Proteomics data for CAPN8 Gene at MOPED

Post-translational modifications for CAPN8 Gene

  • Undergoes autolytic cleavage between Ala-5 and Ala-6 which gives rise to fragments extending from Ala-6 to the C-terminus, Ala-6 to the EF-hand 2 domain and from Ala-6 to the beginning of domain III.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CAPN8 Gene

Gene Families for CAPN8 Gene

Suggested Antigen Peptide Sequences for CAPN8 Gene

Graphical View of Domain Structure for InterPro Entry

A6NHC0

UniProtKB/Swiss-Prot:

CAN8_HUMAN :
  • The domain III mediates oligomerization.
  • Belongs to the peptidase C2 family.
Domain:
  • The domain III mediates oligomerization.
  • Contains 1 calpain catalytic domain.
  • Contains 3 EF-hand domains.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN8: view

Function for CAPN8 Gene

Molecular function for CAPN8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).

Enzyme Numbers (IUBMB) for CAPN8 Gene

Gene Ontology (GO) - Molecular Function for CAPN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
genes like me logo Genes that share ontologies with CAPN8: view
genes like me logo Genes that share phenotypes with CAPN8: view

Animal Models for CAPN8 Gene

MGI Knock Outs for CAPN8:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN8 Gene

Localization for CAPN8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN8 Gene

Cytoplasm. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN8 Gene COMPARTMENTS Subcellular localization image for CAPN8 gene
Compartment Confidence
cytosol 3
golgi apparatus 3
nucleus 3
extracellular 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CAPN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN8: view

Pathways & Interactions for CAPN8 Gene

genes like me logo Genes that share pathways with CAPN8: view

Pathways by source for CAPN8 Gene

1 Tocris pathway for CAPN8 Gene

Interacting Proteins for CAPN8 Gene

Gene Ontology (GO) - Biological Process for CAPN8 Gene

None

No data available for SIGNOR curated interactions for CAPN8 Gene

Drugs & Compounds for CAPN8 Gene

(5) Drugs for CAPN8 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Epoxomicin Pharma Proteasome inhibitor 0
MG-132 Pharma Proteasome inhibitor, Cell permeable, reversible 0
PSI Pharma Proteasome inhibitor 0
calcium Nutra 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(4) Additional Compounds for CAPN8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Acetyl-Calpastatin (184-210) (human)
123714-50-1
Calpeptin
117591-20-5
MG 132
133407-82-6
PD 150606
179528-45-1
genes like me logo Genes that share compounds with CAPN8: view

Transcripts for CAPN8 Gene

mRNA/cDNA for CAPN8 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAPN8 Gene

Calpain 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN8 Gene

No ASD Table

Relevant External Links for CAPN8 Gene

GeneLoc Exon Structure for
CAPN8
ECgene alternative splicing isoforms for
CAPN8

Expression for CAPN8 Gene

mRNA expression in normal human tissues for CAPN8 Gene

mRNA differential expression in normal tissues according to GTEx for CAPN8 Gene

This gene is overexpressed in Stomach (x18.7), Colon - Transverse (x7.9), Bladder (x6.4), and Lung (x5.2).

Protein differential expression in normal tissues from HIPED for CAPN8 Gene

This gene is overexpressed in Stomach (56.6) and Testis (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAPN8 Gene



SOURCE GeneReport for Unigene cluster for CAPN8 Gene Hs.291487

mRNA Expression by UniProt/SwissProt for CAPN8 Gene

A6NHC0-CAN8_HUMAN
Tissue specificity: Stomach.
genes like me logo Genes that share expression patterns with CAPN8: view

Protein tissue co-expression partners for CAPN8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CAPN8 Gene

Orthologs for CAPN8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGC151839 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN8 36
  • 66 (a)
OneToOne
CAPN8 35
  • 81.51 (n)
  • 77.24 (a)
mouse
(Mus musculus)
Mammalia Capn8 16
Capn8 36
  • 72 (a)
OneToOne
Capn8 35
  • 83.78 (n)
  • 83.21 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPN8 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPN8 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capn8 35
  • 84.02 (n)
  • 84.64 (a)
chicken
(Gallus gallus)
Aves CAPN8 35
  • 72.46 (n)
  • 71.94 (a)
CAPN8 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPN8 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn8 35
  • 67.14 (n)
  • 65.95 (a)
zebrafish
(Danio rerio)
Actinopterygii capn8 36
  • 50 (a)
OneToOne
capn8 35
  • 61.23 (n)
  • 56.65 (a)
worm
(Caenorhabditis elegans)
Secernentea clp-1 35
  • 53.86 (n)
  • 51.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4609 36
  • 37 (a)
OneToMany
Species with no ortholog for CAPN8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN8 Gene

ENSEMBL:
Gene Tree for CAPN8 (if available)
TreeFam:
Gene Tree for CAPN8 (if available)

Paralogs for CAPN8 Gene

genes like me logo Genes that share paralogs with CAPN8: view

Variants for CAPN8 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAPN8 Gene

Variant ID Type Subtype PubMed ID
nsv832681 CNV Gain 17160897
nsv873212 CNV Gain 21882294
esv2723417 CNV Deletion 23290073
esv1919956 CNV Deletion 18987734
esv27704 CNV Loss 19812545
nsv821216 CNV Deletion 20802225
dgv59e201 CNV Deletion 23290073
dgv60e201 CNV Deletion 23290073
esv2723473 CNV Deletion 23290073
dgv61e201 CNV Deletion 23290073
esv2741351 CNV Deletion 23290073
esv2742948 CNV Deletion 23290073
esv1388923 CNV Deletion 17803354
esv2740896 CNV Deletion 23290073
dgv62e201 CNV Deletion 23290073
esv2723495 CNV Deletion 23290073
esv34082 CNV Loss 18971310

Variation tolerance for CAPN8 Gene

Gene Damage Index Score: 23.52; 99.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN8 Gene

HapMap Linkage Disequilibrium report
CAPN8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CAPN8 Gene

Disorders for CAPN8 Gene

Relevant External Links for CAPN8

Genetic Association Database (GAD)
CAPN8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPN8

No disorders were found for CAPN8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN8 Gene

Publications for CAPN8 Gene

  1. Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution. (PMID: 11523006) Hata S. … Suzuki K. (J. Mol. Evol. 2001) 3 4 67
  2. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 2 3
  3. A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain. (PMID: 7690035) Sorimachi H. … Suzuki K. (J. Biol. Chem. 1993) 2 3
  4. Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains. (PMID: 17646163) Hata S. … Sorimachi H. (J. Biol. Chem. 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CAPN8 Gene

Sources for CAPN8 Gene

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