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Aliases for CAPN8 Gene

Aliases for CAPN8 Gene

  • Calpain 8 2 3
  • Stomach-Specific M-Type Calpain 3 4
  • New Calpain 2 3 4
  • EC 3.4.22.53 4 64
  • NCL-2 3 4
  • Calpain 8 (NCL-2) 2
  • Calpain-8 3
  • EC 3.4.22 64
  • NCL2 4

External Ids for CAPN8 Gene

Summaries for CAPN8 Gene

GeneCards Summary for CAPN8 Gene

CAPN8 (Calpain 8) is a Protein Coding gene. Among its related pathways are Apoptosis Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN8 Gene

  • Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).

Tocris Summary for CAPN8 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimers disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN8 Gene

Genomics for CAPN8 Gene

Genomic Location for CAPN8 Gene

Start:
223,538,007 bp from pter
End:
223,665,734 bp from pter
Size:
127,728 bases
Orientation:
Minus strand

Genomic View for CAPN8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPN8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN8 Gene

Regulatory Elements for CAPN8 Gene

Proteins for CAPN8 Gene

  • Protein details for CAPN8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHC0-CAN8_HUMAN
    Recommended name:
    Calpain-8
    Protein Accession:
    A6NHC0
    Secondary Accessions:
    • B2RXL2

    Protein attributes for CAPN8 Gene

    Size:
    703 amino acids
    Molecular mass:
    79144 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions.;
    Quaternary structure:
    • Monomer and homooligomer. Interacts with COPS1/GPS1, COPB1, EYA2, NME2, NME4 and TOMM70A (By similarity).

neXtProt entry for CAPN8 Gene

Proteomics data for CAPN8 Gene at MOPED

Post-translational modifications for CAPN8 Gene

  • Undergoes autolytic cleavage between Ala-5 and Ala-6 which gives rise to fragments extending from Ala-6 to the C-terminus, Ala-6 to the EF-hand 2 domain and from Ala-6 to the beginning of domain III.

Domains for CAPN8 Gene

Gene Families for CAPN8 Gene

HGNC:
  • EFHAND :EF-hand domain containing

UniProtKB/Swiss-Prot:

CAN8_HUMAN
Domain:
  • The domain III mediates oligomerization.:
    • A6NHC0
  • Contains 1 calpain catalytic domain.:
    • A6NHC0
  • Contains 3 EF-hand domains.:
    • A6NHC0
Family:
  • Belongs to the peptidase C2 family.:
    • A6NHC0
genes like me logo Genes that share domains with CAPN8: view

Function for CAPN8 Gene

Molecular function for CAPN8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Broad endopeptidase specificity
UniProtKB/Swiss-Prot Function: Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).

Enzyme Numbers (IUBMB) for CAPN8 Gene

Gene Ontology (GO) - Molecular Function for CAPN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CAPN8: view

Phenotypes for CAPN8 Gene

genes like me logo Genes that share phenotypes with CAPN8: view

Animal Models for CAPN8 Gene

MGI Knock Outs for CAPN8:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CAPN8 Gene

Localization for CAPN8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN8 Gene

Cytoplasm. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN8 Gene COMPARTMENTS Subcellular localization image for CAPN8 gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CAPN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with CAPN8: view

Pathways for CAPN8 Gene

SuperPathways for CAPN8 Gene

Superpath Contained pathways
1 Apoptosis Pathway
genes like me logo Genes that share pathways with CAPN8: view

Pathways by source for CAPN8 Gene

1 Tocris pathway for CAPN8 Gene

Interacting Proteins for CAPN8 Gene

Gene Ontology (GO) - Biological Process for CAPN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
GO:0007586 digestion IEA --
genes like me logo Genes that share ontologies with CAPN8: view

Compounds for CAPN8 Gene

(9) ApexBio Compounds for CAPN8 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor. [123714-50-1]
Calpain Inhibitor I, ALLN A cell-permeable inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L. [110044-82-1]
Calpain Inhibitor II, ALLM A cell-permeable inhibitor of calpain 1 and calpain 2. [136632-32-1]
Calpeptin Potent cathepsin L inhibitor [117591-20-5]
E-64 Irriversible cysteine protease inhibitor [66701-25-5]
MDL 28170 Potent, selective inhibitor of calpain and cathepsin B. [88191-84-8]
MG-132 Proteasome and calpain inhibitor. [133407-82-6]
PD 150606 Selective, cell-permeable non-peptide calpain inhibitor. [179528-45-1]
Z-FA-FMK An inhibitor of cysteine proteases, such as cathepsin B.

(5) Tocris Compounds for CAPN8 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor [123714-50-1]
MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
MG 101 Calpain inhibitor; activates p53-dependent apoptosis [110044-82-1]
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation [133407-82-6]
PD 150606 Cell permeable calpain inhibitor [179528-45-1]

(1) HMDB Compounds for CAPN8 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CAPN8: view

Transcripts for CAPN8 Gene

mRNA/cDNA for CAPN8 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAPN8 Gene

Calpain 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN8 Gene

No ASD Table

Relevant External Links for CAPN8 Gene

GeneLoc Exon Structure for
CAPN8
ECgene alternative splicing isoforms for
CAPN8

Expression for CAPN8 Gene

mRNA expression in normal human tissues for CAPN8 Gene

mRNA differential expression in normal tissues according to GTEx for CAPN8 Gene

This gene is overexpressed in Stomach (18.7), Colon - Transverse (7.9), Bladder (6.4), and Lung (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAPN8 Gene

SOURCE GeneReport for Unigene cluster for CAPN8 Gene Hs.291487

mRNA Expression by UniProt/SwissProt for CAPN8 Gene

A6NHC0-CAN8_HUMAN
Tissue specificity: Stomach
genes like me logo Genes that share expressions with CAPN8: view

Orthologs for CAPN8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGC151839 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN8 36
  • 81.51 (n)
  • 77.24 (a)
CAPN8 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capn8 36
  • 83.78 (n)
  • 83.21 (a)
Capn8 16
Capn8 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPN8 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPN8 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capn8 36
  • 84.02 (n)
  • 84.64 (a)
chicken
(Gallus gallus)
Aves CAPN8 36
  • 72.46 (n)
  • 71.94 (a)
CAPN8 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPN8 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn8 36
  • 67.14 (n)
  • 65.95 (a)
zebrafish
(Danio rerio)
Actinopterygii capn8 36
  • 61.23 (n)
  • 56.65 (a)
capn8 37
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clp-1 36
  • 53.86 (n)
  • 51.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4609 37
  • 37 (a)
OneToMany
Species with no ortholog for CAPN8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN8 Gene

ENSEMBL:
Gene Tree for CAPN8 (if available)
TreeFam:
Gene Tree for CAPN8 (if available)

Paralogs for CAPN8 Gene

genes like me logo Genes that share paralogs with CAPN8: view

Variants for CAPN8 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAPN8 Gene

Variant ID Type Subtype PubMed ID
nsv832681 CNV Gain 17160897
nsv873212 CNV Gain 21882294
esv2723417 CNV Deletion 23290073
esv1919956 CNV Deletion 18987734
esv27704 CNV Loss 19812545
nsv821216 CNV Deletion 20802225
dgv59e201 CNV Deletion 23290073
dgv60e201 CNV Deletion 23290073
esv2723473 CNV Deletion 23290073
dgv61e201 CNV Deletion 23290073
esv2741351 CNV Deletion 23290073
esv2742948 CNV Deletion 23290073
esv1388923 CNV Deletion 17803354
esv2740896 CNV Deletion 23290073
dgv62e201 CNV Deletion 23290073
esv2723495 CNV Deletion 23290073
esv34082 CNV Loss 18971310

Relevant External Links for CAPN8 Gene

HapMap Linkage Disequilibrium report
CAPN8

No data available for Sequence variations from dbSNP and Humsavar for CAPN8 Gene

Disorders for CAPN8 Gene

(1) University of Copenhagen DISEASES for CAPN8 Gene

Relevant External Links for CAPN8

Genetic Association Database (GAD)
CAPN8
genes like me logo Genes that share disorders with CAPN8: view

No data available for UniProtKB/Swiss-Prot for CAPN8 Gene

Publications for CAPN8 Gene

  1. Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution. (PMID: 11523006) Hata S. … Suzuki K. (J. Mol. Evol. 2001) 3 4
  2. A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain. (PMID: 7690035) Sorimachi H. … Suzuki K. (J. Biol. Chem. 1993) 2 3
  3. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 2 3
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3
  5. The calpain family and human disease. (PMID: 11516996) Huang Y. … Wang K.K. (Trends Mol Med 2001) 3

Products for CAPN8 Gene

Sources for CAPN8 Gene

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