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Aliases for CAPN7 Gene

Aliases for CAPN7 Gene

  • Calpain 7 2 3
  • PALBH 3 4 6
  • Homolog Of Aspergillus Nidulans PALB 2 3
  • Calpain Like Protease 2 3
  • PalB Homolog 3 4
  • EC 3.4.22.- 4
  • Calpain-7 3
  • EC 3.4.22 63
  • CALPAIN7 3

External Ids for CAPN7 Gene

Previous GeneCards Identifiers for CAPN7 Gene

  • GC03P015177

Summaries for CAPN7 Gene

Entrez Gene Summary for CAPN7 Gene

  • Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPN7 Gene

CAPN7 (Calpain 7) is a Protein Coding gene. Among its related pathways are ERK Signaling and Apoptosis Pathway. GO annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity and MIT domain binding. An important paralog of this gene is CAPN15.

UniProtKB/Swiss-Prot for CAPN7 Gene

  • Calcium-regulated non-lysosomal thiol-protease.

Tocris Summary for CAPN7 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN7 Gene

Genomics for CAPN7 Gene

Regulatory Elements for CAPN7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAPN7 Gene

15,206,152 bp from pter
15,252,918 bp from pter
46,767 bases
Plus strand

Genomic View for CAPN7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN7 Gene

Proteins for CAPN7 Gene

  • Protein details for CAPN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CAPN7 Gene

    813 amino acids
    Molecular mass:
    92652 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAPN7 Gene

neXtProt entry for CAPN7 Gene

Proteomics data for CAPN7 Gene at MOPED

Selected DME Specific Peptides for CAPN7 Gene

Post-translational modifications for CAPN7 Gene

  • Ubiquitination at Lys130, Lys217, Lys320, Lys419, and Lys503
  • Modification sites at PhosphoSitePlus

Other Protein References for CAPN7 Gene

Antibody Products

Domains for CAPN7 Gene

Gene Families for CAPN7 Gene

Suggested Antigen Peptide Sequences for CAPN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN7: view

Function for CAPN7 Gene

Molecular function for CAPN7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease.

Enzyme Numbers (IUBMB) for CAPN7 Gene

Gene Ontology (GO) - Molecular Function for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 20849418
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005515 protein binding IPI 20849418
GO:0090541 MIT domain binding IPI 20849418
genes like me logo Genes that share ontologies with CAPN7: view

Phenotypes for CAPN7 Gene

genes like me logo Genes that share phenotypes with CAPN7: view

Animal Model Products

miRNA for CAPN7 Gene

miRTarBase miRNAs that target CAPN7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPN7

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CAPN7 Gene

Localization for CAPN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN7 Gene

Subcellular locations from

Jensen Localization Image for CAPN7 Gene COMPARTMENTS Subcellular localization image for CAPN7 gene
Compartment Confidence
nucleus 5
cytosol 3
endosome 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CAPN7: view

Pathways for CAPN7 Gene

genes like me logo Genes that share pathways with CAPN7: view

Pathways by source for CAPN7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0010634 positive regulation of epithelial cell migration IDA 23855590
GO:0097264 self proteolysis IDA 20849418
genes like me logo Genes that share ontologies with CAPN7: view

Drugs for CAPN7 Gene

(4) Tocris Compounds for CAPN7 Gene

Compound Action Cas Number
MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
MG 101 Calpain inhibitor; activates p53-dependent apoptosis [110044-82-1]
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation [133407-82-6]
PD 150606 Cell permeable calpain inhibitor [179528-45-1]

(1) HMDB Compounds for CAPN7 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CAPN7: view

Transcripts for CAPN7 Gene

Unigene Clusters for CAPN7 Gene

Calpain 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPN7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a ·
SP1: - - -
SP2: - -
SP3: -

ExUns: 22b · 22c

Relevant External Links for CAPN7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPN7 Gene

mRNA expression in normal human tissues for CAPN7 Gene

Protein differential expression in normal tissues for CAPN7 Gene

This gene is overexpressed in Urine (42.4) and Lymph node (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPN7 Gene

SOURCE GeneReport for Unigene cluster for CAPN7 Gene Hs.595234

mRNA Expression by UniProt/SwissProt for CAPN7 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CAPN7: view

Expression partners for CAPN7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CAPN7 Gene

Orthologs for CAPN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAPN7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAPN7 35
  • 91.14 (n)
  • 95.69 (a)
CAPN7 36
  • 96 (a)
(Canis familiaris)
Mammalia CAPN7 35
  • 93.64 (n)
  • 96.8 (a)
CAPN7 36
  • 97 (a)
(Mus musculus)
Mammalia Capn7 35
  • 89.79 (n)
  • 95.2 (a)
Capn7 16
Capn7 36
  • 95 (a)
(Pan troglodytes)
Mammalia CAPN7 35
  • 99.71 (n)
  • 99.75 (a)
CAPN7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Capn7 35
  • 89.09 (n)
  • 95.33 (a)
(Monodelphis domestica)
Mammalia CAPN7 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
-- 36
  • 77 (a)
-- 36
  • 77 (a)
(Gallus gallus)
Aves CAPN7 35
  • 79.19 (n)
  • 83.74 (a)
CAPN7 36
  • 83 (a)
(Anolis carolinensis)
Reptilia CAPN7 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia capn7 35
  • 74.57 (n)
  • 81.38 (a)
Str.14941 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15745 35
(Danio rerio)
Actinopterygii capn7 35
  • 70.52 (n)
  • 77.12 (a)
capn7 36
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010834 35
  • 51.99 (n)
  • 51.28 (a)
(Caenorhabditis elegans)
Secernentea clp-2 37
  • 41 (a)
clp-2 35
  • 52.37 (n)
  • 43.77 (a)
clp-2 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM13 38
bread mold
(Neurospora crassa)
Ascomycetes NCU00317 35
  • 42.19 (n)
  • 33.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for CAPN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN7 Gene

Gene Tree for CAPN7 (if available)
Gene Tree for CAPN7 (if available)

Paralogs for CAPN7 Gene

Paralogs for CAPN7 Gene

genes like me logo Genes that share paralogs with CAPN7: view

Variants for CAPN7 Gene

Sequence variations from dbSNP and Humsavar for CAPN7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs826425 -- 15,226,499(+) TGACA(A/G)GTTAA intron-variant
rs826426 -- 15,218,358(-) GAGAA(C/T)AAACA intron-variant
rs851847 -- 15,214,131(-) aggcc(A/G)aggcg intron-variant
rs864322 -- 15,221,473(-) gctca(C/T)gcctg intron-variant
rs866653 -- 15,216,307(-) gaaag(A/C)caata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN7 Gene

Variant ID Type Subtype PubMed ID
nsv428413 CNV Gain 18775914
nsv237085 CNV Loss 16902084
nsv525308 CNV Loss 19592680
esv2548358 CNV Insertion 19546169
esv273698 CNV Insertion 20981092
esv271990 CNV Insertion 20981092

Relevant External Links for CAPN7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN7 Gene

Disorders for CAPN7 Gene

Relevant External Links for CAPN7

Genetic Association Database (GAD)

No disorders were found for CAPN7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CAPN7 Gene

Publications for CAPN7 Gene

  1. Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB. (PMID: 11342116) Futai E. … Maeda T. (Biochim. Biophys. Acta 2001) 3 4 23
  2. Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain. (PMID: 10051333) Franz T. … Dear T.N. (Mamm. Genome 1999) 2 3
  3. New era of calpain research. Discovery of tissue-specific calpains. (PMID: 8163008) Sorimachi H. … Suzuki K. (FEBS Lett. 1994) 2 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CAPN7 Gene

Sources for CAPN7 Gene

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