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Aliases for CAPN7 Gene

Aliases for CAPN7 Gene

  • Calpain 7 2 3 5
  • Homolog Of Aspergillus Nidulans PALB 2 3
  • Calpain Like Protease 2 3
  • PalB Homolog 3 4
  • PALBH 3 4
  • EC 3.4.22.- 4
  • Calpain-7 3
  • EC 3.4.22 58
  • CALPAIN7 3

External Ids for CAPN7 Gene

Previous GeneCards Identifiers for CAPN7 Gene

  • GC03P015177
  • GC03P015222
  • GC03P015223
  • GC03P015233

Summaries for CAPN7 Gene

Entrez Gene Summary for CAPN7 Gene

  • Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPN7 Gene

CAPN7 (Calpain 7) is a Protein Coding gene. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Apoptosis Pathway. GO annotations related to this gene include endopeptidase activity and MIT domain binding. An important paralog of this gene is CAPN15.

UniProtKB/Swiss-Prot for CAPN7 Gene

  • Calcium-regulated non-lysosomal thiol-protease.

Tocris Summary for CAPN7 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Additional gene information for CAPN7 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN7 Gene

Genomics for CAPN7 Gene

Regulatory Elements for CAPN7 Gene

Enhancers for CAPN7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H015097 1.2 ENCODE 48.6 -107.3 -107318 2 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NR2C2 CCDC174 CAPN7 SH3BP5-AS1 XPC ENSG00000228242 TMEM43 MRPS25 HACL1 FGD5
GH03H014438 1.9 FANTOM5 Ensembl ENCODE dbSUPER 26.4 -765.7 -765704 3 PKNOX1 ATF1 ARNT ZNF493 FEZF1 ZNF2 TCF12 ZNF121 GLIS2 FOS XPC CCDC174 CAPN7 SLC6A6 NR2C2 ENSG00000230172 ENSG00000223398 HDAC11-AS1 SH3BP5-AS1 TMEM43
GH03H014408 1.9 FANTOM5 Ensembl ENCODE dbSUPER 26.4 -793.3 -793342 8 HDGF PKNOX1 ATF1 ARNT SIN3A ZNF766 GATA2 ELK1 FOS ATF7 CCDC174 XPC CAPN7 SH3BP5-AS1 NR2C2 ENSG00000228242 SLC6A6 GC03P014418
GH03H014450 1.8 FANTOM5 Ensembl ENCODE dbSUPER 26 -752.9 -752854 4 FOXA2 ARNT ARID4B SIN3A FEZF1 GLI4 ZNF121 GLIS2 FOS KLF7 SH3BP5-AS1 CCDC174 SLC6A6 CAPN7 NR2C2 ENSG00000228242 XPC ENSG00000230172 HDAC11-AS1 ENSG00000223398
GH03H015287 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23.8 +86.3 86300 10 HNRNPUL1 PKNOX1 ATF1 SIN3A BRCA1 YY1 TCF12 GATA2 ZNF143 FOS SH3BP5 CAPN7 CCDC174 EAF1 NR2C2 RPS24P10 SH3BP5-AS1 RNU6-454P COL6A4P1 RNU6-1024P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAPN7 on UCSC Golden Path with GeneCards custom track

Promoters for CAPN7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000149027 648 2401 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for CAPN7 Gene

Chromosome:
3
Start:
15,206,152 bp from pter
End:
15,252,918 bp from pter
Size:
46,767 bases
Orientation:
Plus strand

Genomic View for CAPN7 Gene

Genes around CAPN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN7 Gene

Proteins for CAPN7 Gene

  • Protein details for CAPN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W3-CAN7_HUMAN
    Recommended name:
    Calpain-7
    Protein Accession:
    Q9Y6W3

    Protein attributes for CAPN7 Gene

    Size:
    813 amino acids
    Molecular mass:
    92652 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAPN7 Gene

neXtProt entry for CAPN7 Gene

Selected DME Specific Peptides for CAPN7 Gene

Q9Y6W3:
  • GGYDFPGSNS
  • GQSAGGC

Post-translational modifications for CAPN7 Gene

  • Ubiquitination at posLast=130130, Lys217, posLast=320320, posLast=419419, and posLast=503503
  • Modification sites at PhosphoSitePlus

Domains & Families for CAPN7 Gene

Gene Families for CAPN7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CAPN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6W3

UniProtKB/Swiss-Prot:

CAN7_HUMAN :
  • Belongs to the peptidase C2 family.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN7: view

Function for CAPN7 Gene

Molecular function for CAPN7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease.

Enzyme Numbers (IUBMB) for CAPN7 Gene

Phenotypes From GWAS Catalog for CAPN7 Gene

Gene Ontology (GO) - Molecular Function for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 20849418
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA,IEA --
GO:0005515 protein binding IPI 20849418
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with CAPN7: view
genes like me logo Genes that share phenotypes with CAPN7: view

Animal Models for CAPN7 Gene

MGI Knock Outs for CAPN7:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPN7

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAPN7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN7 Gene

Localization for CAPN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPN7 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CAPN7: view

Pathways & Interactions for CAPN7 Gene

genes like me logo Genes that share pathways with CAPN7: view

Pathways by source for CAPN7 Gene

Gene Ontology (GO) - Biological Process for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0010634 positive regulation of epithelial cell migration IDA 23855590
GO:0097264 self proteolysis IDA 20849418
genes like me logo Genes that share ontologies with CAPN7: view

No data available for SIGNOR curated interactions for CAPN7 Gene

Drugs & Compounds for CAPN7 Gene

(2) Drugs for CAPN7 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Acetyl-Calpastatin (184-210) (human) Pharma Calpain I/II inhibitor, Selective calpain inhibitor 0

(1) Additional Compounds for CAPN7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 132
133407-82-6

(2) Tocris Compounds for CAPN7 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
genes like me logo Genes that share compounds with CAPN7: view

Transcripts for CAPN7 Gene

Unigene Clusters for CAPN7 Gene

Calpain 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAPN7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a ·
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for CAPN7 Gene

GeneLoc Exon Structure for
CAPN7
ECgene alternative splicing isoforms for
CAPN7

Expression for CAPN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAPN7 Gene

This gene is overexpressed in Urine (42.4) and Lymph node (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPN7 Gene



Protein tissue co-expression partners for CAPN7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPN7 Gene:

CAPN7

SOURCE GeneReport for Unigene cluster for CAPN7 Gene:

Hs.595234

mRNA Expression by UniProt/SwissProt for CAPN7 Gene:

Q9Y6W3-CAN7_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CAPN7 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CAPN7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN7 Gene

Orthologs for CAPN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAPN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPN7 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia CAPN7 33 34
  • 93.64 (n)
cow
(Bos Taurus)
Mammalia CAPN7 33 34
  • 91.14 (n)
mouse
(Mus musculus)
Mammalia Capn7 33 16 34
  • 89.79 (n)
rat
(Rattus norvegicus)
Mammalia Capn7 33
  • 89.09 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPN7 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves CAPN7 33 34
  • 79.19 (n)
lizard
(Anolis carolinensis)
Reptilia CAPN7 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn7 33
  • 74.57 (n)
Str.14941 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15745 33
zebrafish
(Danio rerio)
Actinopterygii capn7 33 34
  • 70.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010834 33
  • 51.99 (n)
worm
(Caenorhabditis elegans)
Secernentea clp-2 35 33 34
  • 52.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM13 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00317 33
  • 42.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToOne
Species where no ortholog for CAPN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN7 Gene

ENSEMBL:
Gene Tree for CAPN7 (if available)
TreeFam:
Gene Tree for CAPN7 (if available)

Paralogs for CAPN7 Gene

Paralogs for CAPN7 Gene

genes like me logo Genes that share paralogs with CAPN7: view

Variants for CAPN7 Gene

Sequence variations from dbSNP and Humsavar for CAPN7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000067855 -- 15,223,995(+) CTTAT(A/G)TCAAG intron-variant
rs1000080514 -- 15,219,706(+) GAGTT(C/T)TCACA intron-variant
rs1000120044 -- 15,223,779(+) TTTCT(A/G)TAGTG intron-variant
rs1000237992 -- 15,237,698(+) GGCAC(C/T)GTGGG intron-variant
rs1000290101 -- 15,231,474(+) GATGT(A/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN7 Gene

Variant ID Type Subtype PubMed ID
esv2548358 CNV insertion 19546169
esv3595380 CNV loss 21293372
nsv1009775 CNV loss 25217958
nsv237085 CNV deletion 16902084
nsv428413 CNV gain 18775914
nsv525308 CNV loss 19592680

Variation tolerance for CAPN7 Gene

Residual Variation Intolerance Score: 4.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN7 Gene

Disorders for CAPN7 Gene

Relevant External Links for CAPN7

Genetic Association Database (GAD)
CAPN7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPN7

No disorders were found for CAPN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN7 Gene

Publications for CAPN7 Gene

  1. Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB. (PMID: 11342116) Futai E … Maeda T (Biochimica et biophysica acta 2001) 3 4 22 60
  2. Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain. (PMID: 10051333) Franz T … Dear TN (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 60
  3. New era of calpain research. Discovery of tissue-specific calpains. (PMID: 8163008) Sorimachi H … Suzuki K (FEBS letters 1994) 2 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 60

Products for CAPN7 Gene

Sources for CAPN7 Gene

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