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Aliases for CAPN7 Gene

Aliases for CAPN7 Gene

  • Calpain 7 2 3 5
  • Homolog Of Aspergillus Nidulans PALB 2 3
  • Calpain Like Protease 2 3
  • PalB Homolog 3 4
  • PALBH 3 4
  • EC 3.4.22.- 4
  • Calpain-7 3
  • EC 3.4.22 61
  • CALPAIN7 3

External Ids for CAPN7 Gene

Previous GeneCards Identifiers for CAPN7 Gene

  • GC03P015177
  • GC03P015222
  • GC03P015223

Summaries for CAPN7 Gene

Entrez Gene Summary for CAPN7 Gene

  • Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPN7 Gene

CAPN7 (Calpain 7) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Arrhythmogenic right ventricular cardiomyopathy (ARVC). GO annotations related to this gene include endopeptidase activity and MIT domain binding. An important paralog of this gene is CAPN15.

UniProtKB/Swiss-Prot for CAPN7 Gene

  • Calcium-regulated non-lysosomal thiol-protease.

Tocris Summary for CAPN7 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN7 Gene

Genomics for CAPN7 Gene

Regulatory Elements for CAPN7 Gene

Enhancers for CAPN7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G015287 2.1 FANTOM5 Ensembl ENCODE dbSUPER 24.3 +86.3 86300 10.9 HNRNPUL1 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B YY1 CBX5 SH3BP5 CAPN7 EAF1 RPS24P10 SH3BP5-AS1 RNU6-454P COL6A4P1 RNU6-1024P EAF1-AS1 RPS3AP53
GH03G015097 1.2 ENCODE 40.5 -107.3 -107318 2.4 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 CAPN7 SH3BP5-AS1 MRPS25 ENSG00000228242 FGD5 TMEM43 FGD5-AS1 RBSN GC03M015082
GH03G014450 1.8 FANTOM5 Ensembl ENCODE dbSUPER 26 -752.9 -752854 5.0 FOXA2 ARNT ARID4B SIN3A FEZF1 GLI4 ZNF48 ZNF121 GLIS2 GATA2 SH3BP5-AS1 SLC6A6 CAPN7 ENSG00000228242 FGD5 TMEM43 CCDC174 NR2C2 XPC GC03P014432
GH03G015600 1.4 ENCODE dbSUPER 26.9 +395.5 395476 2.5 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 CAPN7 SH3BP5-AS1 HACL1 RBSN COLQ BTD
GH03G014905 1.1 dbSUPER 26.7 -299.4 -299376 3.5 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 CAPN7 SH3BP5-AS1 ENSG00000228242 CCDC174 ENSG00000235629 LOC105376963 PIR49239
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAPN7 on UCSC Golden Path with GeneCards custom track

Promoters for CAPN7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000149027 648 2401 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A

Genomic Location for CAPN7 Gene

Chromosome:
3
Start:
15,206,152 bp from pter
End:
15,252,918 bp from pter
Size:
46,767 bases
Orientation:
Plus strand

Genomic View for CAPN7 Gene

Genes around CAPN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN7 Gene

Proteins for CAPN7 Gene

  • Protein details for CAPN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W3-CAN7_HUMAN
    Recommended name:
    Calpain-7
    Protein Accession:
    Q9Y6W3

    Protein attributes for CAPN7 Gene

    Size:
    813 amino acids
    Molecular mass:
    92652 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAPN7 Gene

neXtProt entry for CAPN7 Gene

Selected DME Specific Peptides for CAPN7 Gene

Q9Y6W3:
  • GGYDFPGSNS
  • GQSAGGC

Post-translational modifications for CAPN7 Gene

  • Ubiquitination at posLast=130130, posLast=217217, Lys320, Lys419, and Lys503
  • Modification sites at PhosphoSitePlus

Domains & Families for CAPN7 Gene

Gene Families for CAPN7 Gene

Suggested Antigen Peptide Sequences for CAPN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6W3

UniProtKB/Swiss-Prot:

CAN7_HUMAN :
  • Belongs to the peptidase C2 family.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN7: view

Function for CAPN7 Gene

Molecular function for CAPN7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease.

Enzyme Numbers (IUBMB) for CAPN7 Gene

Gene Ontology (GO) - Molecular Function for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 20849418
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA,IEA --
GO:0005515 protein binding IPI 20849418
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with CAPN7: view
genes like me logo Genes that share phenotypes with CAPN7: view

Animal Models for CAPN7 Gene

MGI Knock Outs for CAPN7:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPN7

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN7 Gene

Localization for CAPN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPN7 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endosome 2

Gene Ontology (GO) - Cellular Components for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CAPN7: view

Pathways & Interactions for CAPN7 Gene

genes like me logo Genes that share pathways with CAPN7: view

Pathways by source for CAPN7 Gene

Gene Ontology (GO) - Biological Process for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0010634 positive regulation of epithelial cell migration IDA 23855590
GO:0097264 self proteolysis IDA 20849418
genes like me logo Genes that share ontologies with CAPN7: view

No data available for SIGNOR curated interactions for CAPN7 Gene

Drugs & Compounds for CAPN7 Gene

(2) Drugs for CAPN7 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Acetyl-Calpastatin (184-210) (human) Pharma Calpain I/II inhibitor, Selective calpain inhibitor 0

(1) Additional Compounds for CAPN7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 132
133407-82-6

(2) Tocris Compounds for CAPN7 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
genes like me logo Genes that share compounds with CAPN7: view

Transcripts for CAPN7 Gene

Unigene Clusters for CAPN7 Gene

Calpain 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a ·
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for CAPN7 Gene

GeneLoc Exon Structure for
CAPN7
ECgene alternative splicing isoforms for
CAPN7

Expression for CAPN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAPN7 Gene

This gene is overexpressed in Urine (42.4) and Lymph node (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPN7 Gene



Protein tissue co-expression partners for CAPN7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPN7 Gene:

CAPN7

SOURCE GeneReport for Unigene cluster for CAPN7 Gene:

Hs.595234

mRNA Expression by UniProt/SwissProt for CAPN7 Gene:

Q9Y6W3-CAN7_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CAPN7 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CAPN7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN7 Gene

Orthologs for CAPN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAPN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPN7 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia CAPN7 34 35
  • 93.64 (n)
cow
(Bos Taurus)
Mammalia CAPN7 34 35
  • 91.14 (n)
mouse
(Mus musculus)
Mammalia Capn7 34 16 35
  • 89.79 (n)
rat
(Rattus norvegicus)
Mammalia Capn7 34
  • 89.09 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPN7 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves CAPN7 34 35
  • 79.19 (n)
lizard
(Anolis carolinensis)
Reptilia CAPN7 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn7 34
  • 74.57 (n)
Str.14941 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15745 34
zebrafish
(Danio rerio)
Actinopterygii capn7 34 35
  • 70.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010834 34
  • 51.99 (n)
worm
(Caenorhabditis elegans)
Secernentea clp-2 36 34 35
  • 52.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM13 37
bread mold
(Neurospora crassa)
Ascomycetes NCU00317 34
  • 42.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for CAPN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN7 Gene

ENSEMBL:
Gene Tree for CAPN7 (if available)
TreeFam:
Gene Tree for CAPN7 (if available)

Paralogs for CAPN7 Gene

Paralogs for CAPN7 Gene

genes like me logo Genes that share paralogs with CAPN7: view

Variants for CAPN7 Gene

Sequence variations from dbSNP and Humsavar for CAPN7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000067855 -- 15,223,995(+) CTTAT(A/G)TCAAG intron-variant
rs1000080514 -- 15,219,706(+) GAGTT(C/T)TCACA intron-variant
rs1000120044 -- 15,223,779(+) TTTCT(A/G)TAGTG intron-variant
rs1000237992 -- 15,237,698(+) GGCAC(C/T)GTGGG intron-variant
rs1000290101 -- 15,231,474(+) GATGT(A/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN7 Gene

Variant ID Type Subtype PubMed ID
esv2548358 CNV insertion 19546169
esv3595380 CNV loss 21293372
nsv1009775 CNV loss 25217958
nsv237085 CNV deletion 16902084
nsv428413 CNV gain 18775914
nsv525308 CNV loss 19592680

Variation tolerance for CAPN7 Gene

Residual Variation Intolerance Score: 4.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN7 Gene

Disorders for CAPN7 Gene

Relevant External Links for CAPN7

Genetic Association Database (GAD)
CAPN7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPN7

No disorders were found for CAPN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN7 Gene

Publications for CAPN7 Gene

  1. Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB. (PMID: 11342116) Futai E. … Maeda T. (Biochim. Biophys. Acta 2001) 3 4 22 64
  2. Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain. (PMID: 10051333) Franz T. … Dear T.N. (Mamm. Genome 1999) 2 3 64
  3. New era of calpain research. Discovery of tissue-specific calpains. (PMID: 8163008) Sorimachi H. … Suzuki K. (FEBS Lett. 1994) 2 3 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for CAPN7 Gene

Sources for CAPN7 Gene

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