Aliases for CAPN5 Gene
External Ids for CAPN5 Gene
Previous HGNC Symbols for CAPN5 Gene
Previous GeneCards Identifiers for CAPN5 Gene
Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAPN5 Gene
CAPN5 (Calpain 5) is a Protein Coding gene. Diseases associated with CAPN5 include vitreoretinopathy, neovascular inflammatory and exudative vitreoretinopathy 6. Among its related pathways are Degradation of the extracellular matrix and Integrin Pathway. GO annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.