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Aliases for CAPN5 Gene

Aliases for CAPN5 Gene

  • Calpain 5 2 3 5
  • Calpain Htra-3 3 4
  • New Calpain 3 3 4
  • NCL-3 3 4
  • Vitreoretinopathy, Neovascular Inflammatory 2
  • Testis Tissue Sperm-Binding Protein Li 91mP 3
  • EC 61
  • EC 3.4.22.- 4
  • Calpain-5 3
  • EC 3.4.22 61
  • ADNIV 3
  • HTRA3 3
  • VRNI 3
  • NCL3 4

External Ids for CAPN5 Gene

Previous HGNC Symbols for CAPN5 Gene

  • VRNI

Previous GeneCards Identifiers for CAPN5 Gene

  • GC11P079104
  • GC11P078317
  • GC11P077000
  • GC11P076504
  • GC11P076455
  • GC11P076777
  • GC11P073075

Summaries for CAPN5 Gene

Entrez Gene Summary for CAPN5 Gene

  • Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPN5 Gene

CAPN5 (Calpain 5) is a Protein Coding gene. Diseases associated with CAPN5 include Vitreoretinopathy, Neovascular Inflammatory and Posterior Uveitis. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN6.

Tocris Summary for CAPN5 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Gene Wiki entry for CAPN5 Gene

No data available for UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN5 Gene

Genomics for CAPN5 Gene

Regulatory Elements for CAPN5 Gene

Enhancers for CAPN5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F077071 0.8 Ensembl ENCODE 10.5 +7.2 7155 5.6 HDGF ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 FOS RPL21P95 ENSG00000255449 CAPN5 ACER3 OMP
GH11F077081 0.8 Ensembl ENCODE 9.6 +16.0 15957 2.2 SOX13 ZIC2 THRB ZFHX2 POLR2A NR2F6 PRDM10 ZNF600 CREM ZNF652 CAPN5 OMP
GH11F077065 0.2 ENCODE 8.2 -0.2 -153 2.7 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 GLIS2 CBX5 SP3 SP5 RPL21P95 ENSG00000255449 CAPN5 LOC105369400
GH11F077034 0.9 Ensembl ENCODE 7.3 -31.2 -31249 3.4 HDGF ATF1 PKNOX1 ARNT MLX ZFP64 ZNF766 GATA2 FOS SP5 OMP MYO7A ACER3 CAPN5 B3GNT6 LOC105369399
GH11F077045 0.7 Ensembl ENCODE 6 -19.8 -19844 2.6 PKNOX1 ARID4B SIN3A YY1 ELK1 ZNF143 ZNF263 REST SMARCA4 RFX3 OMP CAPN5 LOC105369399 B3GNT6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CAPN5 on UCSC Golden Path with GeneCards custom track

Promoters for CAPN5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000565772 -32 1801 HDGF TBP ARID4B SIN3A RAD21 YY1 SP3 SP5 REST SP1

Genomic Location for CAPN5 Gene

77,066,932 bp from pter
77,126,155 bp from pter
59,224 bases
Plus strand

Genomic View for CAPN5 Gene

Genes around CAPN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN5 Gene

Proteins for CAPN5 Gene

  • Protein details for CAPN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O00263

    Protein attributes for CAPN5 Gene

    640 amino acids
    Molecular mass:
    73169 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CAPN5 Gene

Selected DME Specific Peptides for CAPN5 Gene


Post-translational modifications for CAPN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN5 Gene

Domains & Families for CAPN5 Gene

Gene Families for CAPN5 Gene

Suggested Antigen Peptide Sequences for CAPN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Belongs to the peptidase C2 family.
  • Contains 1 C2 domain.
  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN5: view

Function for CAPN5 Gene

Molecular function for CAPN5 Gene

GENATLAS Biochemistry:
calpain,class B,large polypeptide,calcium independent cysteine proteinase,papain superfamily,nCL-3 type,specifically expressed in colon,small intestine,testis homolog to C elegans sex determination gene tra3
UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.

Enzyme Numbers (IUBMB) for CAPN5 Gene

Gene Ontology (GO) - Molecular Function for CAPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CAPN5: view
genes like me logo Genes that share phenotypes with CAPN5: view

Human Phenotype Ontology for CAPN5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CAPN5 Gene

MGI Knock Outs for CAPN5:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPN5

miRNA for CAPN5 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CAPN5 Gene

Localization for CAPN5 Gene

Subcellular locations from

Jensen Localization Image for CAPN5 Gene COMPARTMENTS Subcellular localization image for CAPN5 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CAPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005925 focal adhesion IDA 21423176
GO:0009986 cell surface IDA 23055945
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CAPN5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPN5 Gene

Pathways & Interactions for CAPN5 Gene

genes like me logo Genes that share pathways with CAPN5: view

Pathways by source for CAPN5 Gene

1 Sino Biological pathway for CAPN5 Gene
1 BioSystems pathway for CAPN5 Gene

Interacting Proteins for CAPN5 Gene

Gene Ontology (GO) - Biological Process for CAPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007165 signal transduction TAS 9339374
genes like me logo Genes that share ontologies with CAPN5: view

No data available for SIGNOR curated interactions for CAPN5 Gene

Drugs & Compounds for CAPN5 Gene

(1) Drugs for CAPN5 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetyl-Calpastatin (184-210) (human) Pharma Calpain I/II inhibitor, Selective calpain inhibitor 0

(1) Additional Compounds for CAPN5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 132

(2) Tocris Compounds for CAPN5 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
genes like me logo Genes that share compounds with CAPN5: view

Transcripts for CAPN5 Gene

Unigene Clusters for CAPN5 Gene

Calpain 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - -

Relevant External Links for CAPN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPN5 Gene

This gene is overexpressed in Colon - Transverse (x7.0).

Protein differential expression in normal tissues from HIPED for CAPN5 Gene

This gene is overexpressed in Testis (18.5) and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAPN5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAPN5 Gene:


SOURCE GeneReport for Unigene cluster for CAPN5 Gene:


mRNA Expression by UniProt/SwissProt for CAPN5 Gene:

Tissue specificity: Expressed in many tissues. Strong expression in the photoreceptor cells of the retina, with a punctate pattern of labeling over the nuclei and inner segments with less expression along the other segments and outer plexiform layer.
genes like me logo Genes that share expression patterns with CAPN5: view

Primer Products

No data available for Protein tissue co-expression partners for CAPN5 Gene

Orthologs for CAPN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAPN5 34
  • 97.86 (n)
(Bos Taurus)
Mammalia CAPN5 34 35
  • 91.04 (n)
(Canis familiaris)
Mammalia CAPN5 34 35
  • 89.53 (n)
(Mus musculus)
Mammalia Capn5 34 16 35
  • 87.92 (n)
(Rattus norvegicus)
Mammalia Capn5 34
  • 87.4 (n)
(Ornithorhynchus anatinus)
Mammalia CAPN5 35
  • 80 (a)
(Monodelphis domestica)
Mammalia CAPN5 35
  • 75 (a)
(Gallus gallus)
Aves CAPN5 34 35
  • 76.79 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia capn5 34
  • 73.12 (n)
African clawed frog
(Xenopus laevis)
Amphibia capn5-prov 34
(Danio rerio)
Actinopterygii capn5b 34 35
  • 70.68 (n)
capn5a 35
  • 69 (a)
(Caenorhabditis elegans)
Secernentea tra-3 36 34 35
  • 46.13 (n)
clp-7 36
  • 40 (a)
clp-6 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3869 35
  • 29 (a)
Species where no ortholog for CAPN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN5 Gene

Gene Tree for CAPN5 (if available)
Gene Tree for CAPN5 (if available)

Paralogs for CAPN5 Gene

(7) SIMAP similar genes for CAPN5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPN5: view

Variants for CAPN5 Gene

Sequence variations from dbSNP and Humsavar for CAPN5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs397514601 Vitreoretinopathy, neovascular inflammatory (VRNI) [MIM:193235], Pathogenic 77,115,423(+) GGCCC(G/T)CCTGG reference, missense
rs397514602 Vitreoretinopathy, neovascular inflammatory (VRNI) [MIM:193235], Pathogenic 77,115,426(+) CCGCC(C/T)GGCGT reference, missense
rs11604536 Benign 77,116,314(+) TGTGT(A/G)TGTGC intron-variant
rs34801837 Benign 77,084,916(+) GAGGA(C/G/T)CAGAA reference, synonymous-codon, missense
rs10160300 -- 77,081,976(+) ACATA(A/G)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN5 Gene

Variant ID Type Subtype PubMed ID
dgv1230n100 CNV gain 25217958
dgv1231n100 CNV gain 25217958
dgv1232n100 CNV gain 25217958
dgv1233n100 CNV gain 25217958
esv1254554 CNV deletion 17803354
esv2744802 CNV deletion 23290073
nsv1040996 CNV gain 25217958
nsv1044491 CNV gain 25217958
nsv1047361 CNV gain 25217958
nsv509434 CNV insertion 20534489
nsv555450 CNV loss 21841781
nsv555451 CNV loss 21841781
nsv825998 CNV gain 20364138
nsv825999 CNV gain 20364138
nsv951045 CNV deletion 24416366

Variation tolerance for CAPN5 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN5 Gene

Disorders for CAPN5 Gene

MalaCards: The human disease database

(8) MalaCards diseases for CAPN5 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vitreoretinopathy, neovascular inflammatory
  • proliferative vitreoretinopathy
posterior uveitis
  • uveitis, posterior
macular dystrophy, dominant cystoid
  • cystoid macular edema
retinal detachment
- elite association - COSMIC cancer census association via MalaCards
Search CAPN5 in MalaCards View complete list of genes associated with diseases


  • Vitreoretinopathy, neovascular inflammatory (VRNI) [MIM:193235]: An autoimmune condition of the eye that sequentially mimics uveitis, retinitis pigmentosa, and proliferative diabetic retinopathy as it progresses to complete blindness. Patients present during the second or third decade of life with posterior uveitis and reduction of the electroretinogram b-wave. They become more symptomatic when cataracts, cystoid macular edema, and disk edema diminish visual acuity during the second stage. Severe vision loss begins during the third stage when proliferative retinal neovascularization and epiretinal membranes appear. There is an ongoing pigmentary retinal degeneration and peripheral visual field loss during all stages. In the fourth stage, proliferative vitreoretinopathy causes tractional retinal detachments at the macula and vitreous base. The fifth or end-stage disease is marked by phthisis. {ECO:0000269 PubMed:23055945}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CAPN5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CAPN5: view

No data available for Genatlas for CAPN5 Gene

Publications for CAPN5 Gene

  1. Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene. (PMID: 9367857) Mugita N. … Nakao M. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 22 64
  2. Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration. (PMID: 23055945) Mahajan V.B. … Stone E.M. (PLoS Genet. 2012) 2 3 4 64
  3. Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity. (PMID: 18657264) SA!ez M.E. … Serrano-RA-os M. (Cardiovasc Diabetol 2008) 3 22 46 64
  4. Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels. (PMID: 17227582) SA!ez M.E. … Serrano-RA-os M. (BMC Med. Genet. 2007) 3 22 46 64
  5. Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome. (PMID: 16396936) GonzA!lez A. … RamA-rez-Lorca R. (Hum. Reprod. 2006) 3 22 46 64

Products for CAPN5 Gene

Sources for CAPN5 Gene

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