Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CAPN5 Gene

protein-coding   GIFtS: 65
GCID: GC11P076777

Calpain 5

(Previous names: vitreoretinopathy, neovascular inflammatory)
(Previous symbol: VRNI)
  See CAPN5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Calpain 51 2     ADNIV2
VRNI1 2 5     calpain-52
Calpain Htra-32 3     EC 3.4.22.-3
New Calpain 32 3     NCL33
nCL-32 3     EC 3.4.228
HTRA32 5     EC 3.4.22.548
Vitreoretinopathy, Neovascular Inflammatory1     

External Ids:    HGNC: 14821   Entrez Gene: 7262   Ensembl: ENSG000001492607   OMIM: 6025375   UniProtKB: O154843   

Export aliases for CAPN5 gene to outside databases

Previous GC identifers: GC11P079104 GC11P078317 GC11P077000 GC11P076504 GC11P076455 GC11P073075


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CAPN5 Gene:
Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular
processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large
subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like
domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is
also called as HTRA3. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAPN5 Gene:
CAPN5 (calpain 5) is a protein-coding gene. Diseases associated with CAPN5 include vitreoretinopathy, neovascular inflammatory. GO annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN6.

summary for CAPN5 Gene:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

Gene Wiki entry for CAPN5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAPN5 gene promoter:
         AhR   STAT1   AP-1   E47   Arnt   AREB6   Ik-2   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPN5 promoter sequence
   Search Chromatin IP Primers for CAPN5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q14

CAPN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P076777:  view genomic region     (about GC identifiers)

Start:
76,777,979 bp from pter      End:
76,837,201 bp from pter
Size:
59,223 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CAN5_HUMAN, O15484 (See protein sequence)
Recommended Name: Calpain-5  
Size: 640 amino acids; 73169 Da
Secondary accessions: O00263

Explore the universe of human proteins at neXtProt for CAPN5: NX_O15484

Explore proteomics data for CAPN5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CAPN5 (O15484) (see all 7)
     RLRNPWG  LVKGHAY  YAGIFHF  EWNGPWSD 


    See CAPN5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004046.2  
    ENSEMBL proteins: 
     ENSP00000467244   ENSP00000278559   ENSP00000435894   ENSP00000432332   ENSP00000409996  

    CAPN5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CAPN5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CAPN5
    GenScript Custom Purified and Recombinant Proteins Services for CAPN5
    Novus Biologicals CAPN5 Proteins
    Novus Biologicals CAPN5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAPN5

     
    Search eBioscience for Proteins for CAPN5 

    CAPN5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CAPN5
    OriGene Custom Antibody Services for CAPN5
    Novus Biologicals CAPN5 Antibodies
    Abcam antibodies for CAPN5
    Cloud-Clone Corp. Antibodies for CAPN5
    ThermoFisher Antibodies for CAPN5
    LSBio Antibodies in human, mouse, rat for CAPN5

    CAPN5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAPN5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAPN5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAPN5
    Cloud-Clone Corp. CLIAs for CAPN5
    Search eBioscience for ELISAs for CAPN5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR001300 Peptidase_C2_calpain_cat
     IPR000169 Pept_cys_AS
     IPR022684 Calpain_cysteine_protease
     IPR022683 Calpain_III
     IPR022682 Calpain_domain_III

    Graphical View of Domain Structure for InterPro Entry O15484

    ProtoNet protein and cluster: O15484

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001300 Calpain cysteine protease (C2) family signature


    UniProtKB/Swiss-Prot: CAN5_HUMAN, O15484
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 calpain catalytic domain


    Find genes that share domains with CAPN5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAN5_HUMAN, O15484
    Catalytic activity: Broad endopeptidase specificity

         Genatlas biochemistry entry for CAPN5:
    calpain,class B,large polypeptide,calcium independent cysteine proteinase,papain superfamily,nCL-3
    type,specifically expressed in colon,small intestine,testis homolog to C elegans sex determination gene tra3

         Enzyme Numbers (IUBMB): EC 3.4.22.542 EC 3.4.222 EC 3.4.22.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IBA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CAPN5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CAPN5:
     Decreased number of cells in m 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Capn5):
     behavior/neurological  growth/size/body  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with CAPN5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPN5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAPN5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPN5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPN5

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAPN5:
    hsa-mir-335-5p (MIRT018144), hsa-mir-124-3p (MIRT022741)

    Block miRNA regulation of human, mouse, rat CAPN5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPN5 (see all 34):
    hsa-miR-579 hsa-miR-3194-5p hsa-miR-938 hsa-miR-30d hsa-miR-650 hsa-miR-449a hsa-miR-30a hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidCAPN5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAPN5
    Predesigned siRNA for gene silencing in human, mouse, rat CAPN5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAPN5

    Clone
    Products:
         
    OriGene clones in human, mouse for CAPN5 (see all 6)
    OriGene ORF clones in mouse, rat for CAPN5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAPN5 (NM_004055)
    Sino Biological Human cDNA Clone for CAPN5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CAPN5
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAPN5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0009986cell surface IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CAPN5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CAPN5 About    
    See pathways by source

    SuperPathContained pathways About
    1DREAM Repression and Dynorphin Expression
    nNOS Signaling in Skeletal Muscle0.37
    Calpain Protease Regulates Cellular Mechanics0.31
    Caspase Cascade0.36
    2Integrin Pathway
    FAK1 Signaling0.67
    3ERK Signaling
    ERK Signaling0.61
    4Apoptosis Pathway
    Apoptosis Pathway0.45
    5Focal adhesion
    Integrin-mediated cell adhesion0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CAPN5
        Caspase Cascade
    ERK Signaling
    Calpain Protease Regulates Cellular Mechanics
    FAK1 Signaling
    nNOS Signaling in Skeletal Muscle

    1 Tocris Bioscience Pathway for CAPN5
        Apoptosis Pathway

    1 BioSystems Pathway for CAPN5
        Integrin-mediated cell adhesion



        Pathway & Disease-focused RT2 Profiler PCR Array including CAPN5: 
              Necrosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CAPN5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CAPN5 (O154843 ENSP000002785594) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406923I2D: score=1 
    PSMA3ENSP000002164554STRING: ENSP00000216455
    UBCENSP000003448184STRING: ENSP00000344818
    CHMP4AENSP000003242054STRING: ENSP00000324205
    CHMP4BENSP000002174024STRING: ENSP00000217402
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IBA--
    GO:0007165signal transduction TAS9339374

    Find genes that share ontologies with CAPN5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    9 ApexBio Compounds for CAPN5     About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    Calpain Inhibitor I, ALLNA cell-permeable inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L. [110044-82-1]
    Calpain Inhibitor II, ALLMA cell-permeable inhibitor of calpain 1 and calpain 2[136632-32-1]
    CalpeptinPotent, cell-permeable inhibitor of calpain[117591-20-5]
    E-64Irriversible cysteine protease inhibitor[66701-25-5]
    MDL 28170Potent, selective inhibitor of calpain and cathepsin B[88191-84-8]
    MG-132Proteasome and calpain inhibitor[133407-82-6]
    PD 150606Selective, cell-permeable non-peptide calpain inhibitor[179528-45-1]
    Z-FA-FMKAn inhibitor of cysteine proteases, such as cathepsin B--

    Compounds for CAPN5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    PD 150606Cell permeable calpain inhibitor[179528-45-1]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CAPN5 gene: 
    NM_004055.4  

    Unigene Cluster for CAPN5:

    Calpain 5
    Hs.248153  [show with all ESTs]
    Unigene Representative Sequence: NM_004055
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531028 ENST00000278559(uc001oxx.3 uc009yup.3 uc009yuq.3 uc001oxy.3 uc001oya.3)
    ENST00000527066 ENST00000529629 ENST00000456580 ENST00000533889 ENST00000527129

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CAPN5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPN5 (see all 34):
    hsa-miR-579 hsa-miR-3194-5p hsa-miR-938 hsa-miR-30d hsa-miR-650 hsa-miR-449a hsa-miR-30a hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidCAPN5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CAPN5
    Predesigned siRNA for gene silencing in human, mouse, rat CAPN5
    Clone
    Products:
         
    OriGene clones in human, mouse for CAPN5 (see all 6)
    OriGene ORF clones in mouse, rat for CAPN5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAPN5 (NM_004055)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CAPN5
    OriGene qSTAR qPCR primer pairs in human, mouse for CAPN5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAPN5
      QuantiTect SYBR Green Assays in human, mouse, rat CAPN5
      QuantiFast Probe-based Assays in human, mouse, rat CAPN5

    Additional mRNA sequence: 

    AB209087.1 AK092880.1 AK094150.1 AK310978.1 AK313132.1 BC018123.1 HQ013241.1 S71614.1 
    U94346.1 Y10552.1 

    9 DOTS entries:

    DT.100775674  DT.97808190  DT.100775670  DT.95174533  DT.100775673  DT.95325157  DT.100036072  DT.120758100 
    DT.120758125 

    Selected AceView cDNA sequences (see all 179):

    CB160553 AI475158 BM798667 BF436865 AI222834 BM721120 BU627316 AI802546 
    F08297 BX102047 CD514215 BM701961 BC018123 BM679546 NM_004055 F02396 
    BU729627 AI684512 AI572191 CB140941 BE858417 BM757026 AL528165 AI018176 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAPN5 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                    -                 -                                                                       -                                       
    SP2:                    -     -                                                                                   -                                       
    SP3:                    -     -           -                                                                       -                                       
    SP4:                          -           -                                                                                                               
    SP5:                    -     -           -           -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for CAPN5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CAPN5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCCACCC
    CAPN5 Expression
    About this image


    CAPN5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Colon (Gastrointestinal Tract)
     
     Liver (Hepatobiliary System)
     
     Stomach (Gastrointestinal Tract)
    CAPN5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPN5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248153

    UniProtKB/Swiss-Prot: CAN5_HUMAN, O15484
    Tissue specificity: Expressed in many tissues. Strong expression in the photoreceptor cells of the retina, with a
    punctate pattern of labeling over the nuclei and inner segments with less expression along the other segments and
    outer plexiform layer

        Pathway & Disease-focused RT2 Profiler PCR Array including CAPN5: 
              Necrosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CAPN5
    OriGene qSTAR qPCR primer pairs in human, mouse for CAPN5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAPN5
    QuantiTect SYBR Green Assays in human, mouse, rat CAPN5
    QuantiFast Probe-based Assays in human, mouse, rat CAPN5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CAPN5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capn51 , 5 calpain 51, 5 87.92(n)1
    92.19(a)1
      7 (53.57 cM)5
    123371  NM_007602.31  NP_031628.11 
     981215595 
    chicken
    (Gallus gallus)
    Aves CAPN51 calpain 5 76.79(n)
    79.81(a)
      419086  XM_417278.3  XP_417278.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia capn5-prov2 calpain 5 76.42(n)    BC048218.1 
    zebrafish
    (Danio rerio)
    Actinopterygii capn5b1 calpain 5b 70.68(n)
    71.72(a)
      100006332  XM_001345078.3  XP_001345114.2 
    worm
    (Caenorhabditis elegans)
    Secernentea clp-73
    tra-31
    tra-31 40(a)
    (best of 3)3
    46.13(n)1
    41.83(a)1
      IV(1435632-1445971)3
    1783851  NM_070350.41  NP_502751.11 


    ENSEMBL Gene Tree for CAPN5 (if available)
    TreeFam Gene Tree for CAPN5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CAPN5 gene
    CAPN62  CAPN82  CAPN142  CAPNS12  CAPN132  CAPN12  CAPN92  CAPN32  
    CAPNS22  CAPN22  CAPN122  CAPN112  CAPN102  
    7 SIMAP similar genes for CAPN5 using alignment to 4 protein entries:     CAN5_HUMAN (see all proteins):
    CAPN6    CAPN2    CAPN9    CAPN11    CAPN8    CAPN14
    CAPN3

    Find genes that share paralogs with CAPN5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CAPN5 (see all 1412)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692774
    Vitreoretinopathy, neovascular inflammatory (VRNI)4--see VAR_0692772 R L mis40--------
    VAR_0692784
    Vitreoretinopathy, neovascular inflammatory (VRNI)4--see VAR_0692782 L P mis40--------
    rs38327351,2
    C--73102237(-) CAGAC-/GTGACA
    GACACAGAC
    TTGCT
    1 -- int10--------
    rs1463364481,2
    --73102266(+) TGTCAC/TGTCTC 1 -- int10--------
    rs108993481,2
    C,F,A,H--76641542(+) GGAATA/GAGGTT 1 -- us2k111Minor allele frequency- G:0.36NA WA CSA EA 373
    rs1907146781,2
    --76641572(+) GATGGC/GGTGCA 1 -- us2k10--------
    rs1399036401,2
    C--76641660(+) TGAGGC/GGGCTG 1 -- us2k10--------
    rs19440311,2
    C,F,A--76641806(-) TGAAAA/GGACTC 1 -- us2k12Minor allele frequency- G:0.01MN WA 302
    rs1819192831,2
    --76641814(+) TCAGGC/GGGAAT 1 -- us2k10--------
    rs19440301,2
    C,F--76641852(-) GTGCTC/TATTTA 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for CAPN5 (76777979 - 76837201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CAPN5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744802CNV Deletion23290073
    esv1254554CNV Deletion17803354
    nsv509434CNV Insertion20534489
    nsv897935CNV Loss21882294
    dgv1225n71CNV Loss21882294
    nsv825998CNV Gain20364138
    nsv825999CNV Gain20364138

    Human Gene Mutation Database (HGMD): CAPN5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAPN5
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPN5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602537   
    OMIM disorders: 193235  
    UniProtKB/Swiss-Prot: CAN5_HUMAN, O15484
  • Vitreoretinopathy, neovascular inflammatory (VRNI) [MIM:193235]: An autoimmune condition of the eye that
    sequentially mimics uveitis, retinitis pigmentosa, and proliferative diabetic retinopathy as it progresses to
    complete blindness. Patients present during the second or third decade of life with posterior uveitis and
    reduction of the electroretinogram b-wave. They become more symptomatic when cataracts, cystoid macular edema,
    and disk edema diminish visual acuity during the second stage. Severe vision loss begins during the third stage
    when proliferative retinal neovascularization and epiretinal membranes appear. There is an ongoing pigmentary
    retinal degeneration and peripheral visual field loss during all stages. In the fourth stage, proliferative
    vitreoretinopathy causes tractional retinal detachments at the macula and vitreous base. The fifth or end-stage
    disease is marked by phthisis. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 1 disease for CAPN5:    
    About MalaCards
    vitreoretinopathy, neovascular inflammatory

    1 disease from the University of Copenhagen DISEASES database for CAPN5:
    Neuronal ceroid lipofuscinosis

    Find genes that share disorders with CAPN5           About GenesLikeMe

    2 Novoseek inferred disease relationships for CAPN5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 43.9 1 16396936 (1)
    obesity 35.5 4 17151322 (1), 16396936 (1), 18657264 (1)

    Genetic Association Database (GAD): CAPN5
    Human Genome Epidemiology (HuGE) Navigator: CAPN5 (8 documents)

    Export disorders for CAPN5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CAPN5 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with CAPN5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene. (PubMed id 9367857)1, 2, 3, 9 Mugita N.... Nakao M. (Biochem. Biophys. Res. Commun. 1997)
    2. Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration. (PubMed id 23055945)1, 2, 3 Mahajan V.B.... Stone E.M. (PLoS Genet. 2012)
    3. Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels. (PubMed id 17227582)1, 4, 9 SA!ez M.E....Serrano-RA-os M. (BMC Med. Genet. 2007)
    4. Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome. (PubMed id 16396936)1, 4, 9 GonzA!lez A....RamA-rez-Lorca R. (Hum. Reprod. 2006)
    5. Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity. (PubMed id 18657264)1, 4, 9 SA!ez M.E....Serrano-RA-os M. (Cardiovasc Diabetol 2008)
    6. A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. (PubMed id 9339374)1, 2, 9 Dear T.N.... Boehm T. (Genomics 1997)
    7. Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily. (PubMed id 9503024)1, 3, 9 Matena K....Dear N. (Genomics 1998)
    8. Family-based analysis of candidate genes for polycystic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (J. Clin. Endocrinol. Metab. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 726 HGNC: 1482 AceView: CAPN5 Ensembl:ENSG00000149260 euGenes: HUgn726
    ECgene: CAPN5 H-InvDB: CAPN5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CAPN5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CAPN5 gene:
    Search GeneIP for patents involving CAPN5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CAPN5   OriGene RNAi products in human, mouse, rat for CAPN5  
     OriGene qPCR primer pairs and template standards for CAPN5   OriGene Protein Over-expression Lysate for CAPN5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CAPN5  
     OriGene qSTAR qPCR primer pairs in human, mouse for CAPN5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CAPN5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CAPN5   OriGene Custom Protein Services for CAPN5  

     
     
     Block miRNA regulation of human, mouse, rat CAPN5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CAPN5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPN5 Predesigned siRNA for gene silencing in human, mouse, rat CAPN5
     QuantiFast Probe-based Assays in human, mouse, rat CAPN5 QuantiTect SYBR Green Assays in human, mouse, rat CAPN5
     PCR Arrays including human, mouse, rat CAPN5 Search Chromatin IP Primers for CAPN5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAPN5  Search GeneGlobe Interaction Network for CAPN5
     Regulatory tfbs in CAPN5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CAPN5 GenScript cDNA clones with any tag delivered in your preferred vector for CAPN5
     GenScript Custom Assay Services for CAPN5 GenScript Custom overexpressing Cell Line Services for CAPN5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for CAPN5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CAPN5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CAPN5 antibodies
     CAPN5 proteins
     CAPN5 lysates
     Antibodies for CAPN5
     See all of Abcam's Antibodies, Kits and Proteins for CAPN5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CAPN5
     Antibodies for CAPN5
     ELISAs for CAPN5
     CLIAs for CAPN5



     Browse ESI BIO Cell Lines and PureStem Progenitors for CAPN5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN5
     SwitchGear 3'UTR luciferase reporter plasmids for CAPN5
     SwitchGear Promoter luciferase reporter plasmids for CAPN5
     ThermoFisher Antibodies for CAPN5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPN5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAPN5
     LSBio Antibodies in human, mouse, rat for CAPN5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for CAPN5
     Search Addgene for plasmids for CAPN5
      Search eBioscience for proteins for CAPN5
      Search eBioscience for elisas for CAPN5
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CAPN5 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4