CAPN2 Gene
protein-coding GIFtS: 66
GCID: GC01P223890
|
|
calpain 2, (m/II) large subunit
| |
Aliases
for CAPN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calpain 2, (M/II) Large Subunit1 2 | | EC 3.4.22.533 8 | | CANPL21 2 3 | | CANP22 | | CANPml1 2 | | Calpain 2, Large [Catalytic] Subunit2 | | MCANP1 | | Calpain 2, Large Subunit2 | | Calcium-Activated Neutral Proteinase 22 3 | | Calpain, Large Polypeptide L22 | | Calpain Large Polypeptide L22 3 | | Calpain-2 Catalytic Subunit2 | | Calpain M-Type2 3 | | Millimolar-Calpain1 | | Calpain-2 Large Subunit2 3 | | Millimolar-Calpain1 | | M-Calpain1 | | EC 3.4.228 | | CANP 22 3 | | |
Export aliases for CAPN2 gene to outside databasesPrevious GC identifers: GC01M222640 GC01M219933 GC01P220400 GC01P220874 GC01P220206 GC01P221966 GC01P194501 |
Summaries
for CAPN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CAPN2:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammaliancalpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist ofheterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This geneencodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites inthe 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Mar 2009)
UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved incytoskeletal remodeling and signal transduction
 summary
for CAPN2: Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).
Gene Wiki entry for CAPN2
|
Genomic Views
for CAPN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CAPN2 gene promoter:
HOXA9 HOXA9B Bach1 p53 MyoD MIF-1 C/EBPalpha Pax-3 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAPN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q41-q42 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41-q42CAPN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P223890: view genomic region
(about GC identifiers)
Start:
|
223,889,295 bp from pter |
End:
|
223,963,720 bp from pter |
Size:
|
74,426 bases |
Orientation:
|
plus strand |
|
Proteins
for CAPN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655 (See
protein sequence)Recommended Name: Calpain-2 catalytic subunit precursor Size: 700 amino acids; 79995 Da
Cofactor: Binds 7 calcium ions (By similarity)
Subunit: Forms a heterodimer with a small (regulatory) subunit (CAPNS1)
Subcellular location: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding
Sequence caution: Sequence=AAH07686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAH11828.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
3 PDB 3D structures from  and Proteopedia  for CAPN2:1KFU (3D)
1KFX (3D)
2NQA (3D)
Secondary accessions: A6NDG7 B7ZA96 E7ES58 Q16738 Q6PJT3 Q8WU26 Q9HBB1Alternative splicing: 2 isoforms: P17655-1 P17655-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CAPN2: NX_P17655
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17655
4/32 DME Specific Peptides for CAPN2 (P17655) (see all 32)
CAPN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001139540.1 NP_001739.2
ENSEMBL proteins: ENSP00000399949 ENSP00000295006 ENSP00000413158
Human Recombinant Protein Products for CAPN2:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CAPN2 for ontologies About GeneDecksing
CAPN2 Antibody Products:
Assay Products for CAPN2: |
Protein
Domains /
Families
for CAPN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAPN2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P17655ProtoNet protein and cluster: P17655 1 Blocks protein family: IPB001300 Calpain cysteine protease (C2) family signature
UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655Similarity: Belongs to the peptidase C2 familySimilarity: Contains 1 calpain catalytic domainSimilarity: Contains 3 EF-hand domains |
Function
for CAPN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CAN2_HUMAN, P17655Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved incytoskeletal remodeling and signal transductionCatalytic activity: Broad endopeptidase specificityEnzyme regulation: Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin Genatlas biochemistry entry for CAPN2:calpain,class A,large polypeptide L2,calcium dependent neutral cysteine proteinase,papain superfamily,m type
Enzyme Numbers (IUBMB): EC 3.4.22.531 2 EC 3.4.222
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
CAPN2 for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for CAPN2:
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Capn2):
CAPN2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for CAPN2: Capn2tm1Tcs Capn2tm1Pag
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CAPN2 (NM_001146068) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAPN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN2 |
|
Pathways & Interactions
for CAPN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | DREAM Repression and Dynorphin Expression | | | 2 | Focal Adhesion | | | 3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 4 | Development_Endothelin-1/EDNRA transactivation of EGFR | | | 5 | Protein Stability | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CAPN2
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAPN2 (see all 6)
2 
Cell Signaling Technology (CST) Pathways for CAPN2
1 Tocris Bioscience Pathway for CAPN2
1  GeneGo (Thomson Reuters) Pathway for CAPN2
4  BioSystems Pathways for CAPN2
4 
Kegg Pathways (Kegg details for CAPN2):
CAPN2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAPN2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/30 Interacting proteins for CAPN2 (P176551, 2, 3 ENSP000002950064) via UniProtKB, MINT, STRING, and/or I2D (see all 30)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CAPNS1 | P046321, 2, 3, ENSP000002465334 | EBI-1028956,EBI-711828 MINT-6549073 MINT-25053 I2D:
score=9 STRING: ENSP00000246533 | | NMT1 | P304192, 3, ENSP000002589604 | MINT-1795337 I2D:
score=2 STRING: ENSP00000258960 | | TNS1 | Q9HBL02, 3, ENSP000001718874 | MINT-8216416 I2D:
score=2 STRING: ENSP00000171887 | | CAST | P208102, 3, ENSP000003791584 | MINT-6549073 I2D:
score=1 STRING: ENSP00000379158 | | PTPN1 | P180312, 3, ENSP000003606834 | MINT-6793394 I2D:
score=4 STRING: ENSP00000360683 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
CAPN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CAPN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CAPN2 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for CAPN2 |
Compounds for CAPN2 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| MDL 28170 | Potent, selective calpain and cathepsin B inhibitor | [88191-84-8] | | PD 150606 | Cell permeable calpain inhibitor | [179528-45-1] | | Calpeptin | Calpain and cathepsin L inhibitor | [117591-20-5] | | MG 132 | Proteasome and calpain inhibitor. Inhibits NF-kappaB activation | [133407-82-6] | | MG 101 | Calpain inhibitor; activates p53-dependent apoptosis | [110044-82-1] |
1 HMDB Compound for CAPN2 About this table
10/24 Novoseek chemical compound relationships for CAPN2 gene (see all 24) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| calpeptin |
84.6 |
5 |
8158145 (2), 9514420 (2), 8474564 (1) |
| pd150606 |
73.8 |
2 |
8692879 (1) |
| cysteine |
71.1 |
21 |
12014988 (1), 14711513 (1), 10666632 (1), 14656436 (1) (see all 20) |
| e 64d |
57.2 |
2 |
17301064 (1), 11264351 (1) |
| calcium |
55.9 |
89 |
8739157 (4), 14656436 (3), 14993287 (3), 20089917 (3) (see all 38) |
| deae-cellulose |
39 |
3 |
1548485 (1), 8347679 (1) |
| leupeptin |
35.5 |
3 |
9514420 (2), 8474564 (1) |
| ritonavir |
24.5 |
3 |
14555228 (2), 15629450 (1) |
| serine |
21.4 |
3 |
8568927 (1), 11102442 (1), 9514420 (1) |
| dithiothreitol |
20.5 |
2 |
10942731 (1), 8907176 (1) |
Search CenterWatch for drugs/clinical trials and news about CAPN2 / CAN2
|
Transcripts
for CAPN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CAPN2 gene (2 alternative transcripts): NM_001146068.1 NM_001748.4 Unigene Cluster for CAPN2: Calpain 2, (m/II) large subunit Hs.350899 [show with all ESTs]Unigene Representative Sequence: AK12475112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000434648 ENST00000295006(uc001hob.4) ENST00000483579 ENST00000480581
ENST00000474026(uc001hoc.3) ENST00000487223 ENST00000492565 ENST00000472601
ENST00000498027 ENST00000492664 ENST00000463997 ENST00000433674(uc010puy.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CAPN2 (NM_001146068) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAPN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN2 |
Additional cDNA sequence: AB209855.1 AF261089.1 AK023851.1 AK055046.1 AK056838.1 AK097247.1 AK124751.1 AK297800.1 AK303952.1 AK315179.1 AK316211.1 BC007686.2 BC011828.2 BC021303.2 M23254.1 24/34 DOTS entries (see all 34): DT.448482 DT.95270281 DT.92451372 DT.100666812 DT.92451361 DT.75156340 DT.86852739 DT.95270282 DT.40227680 DT.100714757 DT.100741239 DT.121366908 DT.121366935 DT.121366957 DT.92451373 DT.100863941 DT.121366903 DT.121366947 DT.91698379 DT.92451344 DT.95270275 DT.95270280 DT.100741234 DT.100741255 24/562 AceView cDNA sequences (see all 562): CB268553 BF593436 AI935986 AI921182 AI692612 BU684527 BF593235 AW627461 CB123111 R77216 BM556129 F08088 BQ956396 CB143105 AI273080 AI889116 BM769914 AU141061 BQ922418 CB136507 BX283155 AI635094 CB139837 R77217
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN2 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | · | 19c | ^ | 20a | · | 20b |
|---|
|
| SP1: | - | | - | | | | | | |
| SP2: | - | | - | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for CAPN2
|
Expression
for CAPN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CAPN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTAGAGG
About this image
See CAPN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAPN2
SOURCE GeneReport for Unigene cluster: Hs.350899
UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including CAPN2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAPN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN2 |
Orthologs
for CAPN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CAPN2 gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CAPN21 |
calpain 2, (m/II) large subunit |
77.95(n)
81.29(a) |
|
395963 NM_205080.1 NP_990411.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CAPN26 |
-- |
80(a) |
1 ↔ 1 |
1(245070417-245128447) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC684742 |
hypothetical protein MGC68474 |
74.57(n) |
|
BC063733.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC054941.12 |
-- |
74.62(n) |
|
393417 BC054941.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CalpA3 |
actin cytoskeleton organization and
biogenesis more |
49(a)
(best of 3) |
|
56D5 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
clp-73 |
-- |
45(a)
(best of 3) |
|
IV(1435632-1445971) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATDEK16 |
calpain-type cysteine protease |
5(a) |
1 → many |
1(20653820-20665095) |
rice
(Oryza sativa) |
Liliopsida |
-- |
calpain, putative, expressed |
5(a) |
1 → many |
2(29335385-29352022) |
ENSEMBL Gene Tree for CAPN2 (if available)
TreeFam Gene Tree for CAPN2 (if available) |
Paralogs
for CAPN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CAPN2 gene
- CAPN62 CAPN82 CAPN142 CAPN132 CAPN52 CAPN92 CAPN12 CAPN32
- CAPN72 CAPN122 SOLH2 CAPN112 CAPN102
14 SIMAP similar genes for CAPN2 using alignment to 2 protein entries: CAN2_HUMAN (see all proteins):CAPN1 CAPN8 CAPN11 CAPNS1 CAPN3 CAPN9
CAPN14 CAPNS2 CAPN12 CAPN5 SRI GCA
CAPN6 CAPN13
CAPN2 for paralogs About GeneDecksing
|
Genomic Variants
for CAPN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CAPN2 (223889295 - 223963720 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CAPN2
3 CNVs: 47889 3331 48249
1 Indel: 10655 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAPN2 |
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Disorders
/ Diseases
for CAPN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CAPN2 for disorders About GeneDecksing
OMIM gene information: 114230
OMIM disorders: --
20/41  diseases for CAPN2 (see all 41): About MalaCardsmuscular dystrophy limb-girdle muscular dystrophy alzheimer's disease gastric cancer
dna topoisomerase i duchenne muscular dystrophy aortic aneurysm rheumatoid arthritis
primary hyperparathyroidism basal cell carcinoma chronic lymphocytic leukemia muscular atrophy
neurodegenerative disease lymphocytic leukemia parkinson's disease hyperparathyroidism
cataract squamous cell carcinoma hepatocellular carcinoma osteoarthritis
10/20 Novoseek disease relationships for CAPN2 gene (see all 20) About this table
Human Genome Epidemiology (HuGE) Navigator: CAPN2 (8 documents)
Export disorders for CAPN2 gene to outside databases
|
Publications
for CAPN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CAPN2 gene, integrated from 9 sources (see all 305):
(articles sorted by number of sources associating them with CAPN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease. (PubMed id 2539381)1, 2, 3 Hata A....Suzuki K. (1989)
- Molecular cloning of the cDNA for the large subunit of the high-Ca2+- requiring form of human Ca2+-activated neutral protease. (PubMed id 2852952)1, 2, 3 Imajoh S....Suzuki K. (1988)
- The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. (PubMed id 10639123)1, 2, 9 Strobl S.... Bode W. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. (PubMed id 10944468)1, 2 Ye Z. and Connor J.R. (2000)
- Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. (PubMed id 15471877)1, 9 Xu L. and Deng X. (2004)
- m-Calpain antagonizes RhoA overactivation and endothe lial barrier dysfunction under disturbed shear conditions. (PubMed id 19752040)1, 9 Miyazaki T....Ohata H. (2010)
- Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains. (PubMed id 16361262)1, 9 Xu L. and Deng X. (2006)
|
External Searches for CAPN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CAPN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CAPN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CAPN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CAPN2 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/capn2/ |
|
| | |
About This Section
| Patent Information for CAPN2 gene:
Search GeneIP for patents involving CAPN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAPN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
 |
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(calpain 2) |
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