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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPN2 Gene

protein-coding   GIFtS: 69
GCID: GC01P223890

Calpain 2, (M/II) Large Subunit

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calpain 2, (M/II) Large Subunit1 2     CANPml2
Calcium-Activated Neutral Proteinase 22 3     Calpain 2, Large [Catalytic] Subunit2
Calpain Large Polypeptide L22 3     Calpain 2, Large Subunit2
Calpain M-Type2 3     Calpain, Large Polypeptide L22
Calpain-2 Large Subunit2 3     Calpain-2 Catalytic Subunit2
CANPL22 3     mCANP2
M-calpain2 3     millimolar-calpain2
CANP 22 3     Millimolar-calpain3
EC 3.4.22.533 8     EC 3.4.228
CANP22     

External Ids:    HGNC: 14791   Entrez Gene: 8242   Ensembl: ENSG000001629097   OMIM: 1142305   UniProtKB: P176553   

Export aliases for CAPN2 gene to outside databases

Previous GC identifers: GC01M222640 GC01M219933 GC01P220400 GC01P220874 GC01P220206 GC01P221966 GC01P194501


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAPN2 Gene:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The
mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes
consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory
subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous
transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for CAPN2 Gene: 
CAPN2 (calpain 2, (m/II) large subunit) is a protein-coding gene. Diseases associated with CAPN2 include muscular dystrophy, and primary hyperparathyroidism, and among its related super-pathways are Focal Adhesion and Parkinson's disease. GO annotations related to this gene include cysteine-type peptidase activity and calcium ion binding. An important paralog of this gene is CAPN6.

UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655
Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved
in cytoskeletal remodeling and signal transduction

summary for CAPN2 Gene:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

Gene Wiki entry for CAPN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPN2 gene promoter:
         HOXA9   HOXA9B   Bach1   p53   MyoD   MIF-1   C/EBPalpha   Pax-3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41-q42   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41-q42

CAPN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P223890:  view genomic region     (about GC identifiers)

Start:
223,889,295 bp from pter      End:
223,963,720 bp from pter
Size:
74,426 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655 (See protein sequence)
Recommended Name: Calpain-2 catalytic subunit precursor  
Size: 700 amino acids; 79995 Da
Cofactor: Binds 7 calcium ions (By similarity)
Subunit: Forms a heterodimer with a small (regulatory) subunit (CAPNS1)
Subcellular location: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding
Sequence caution: Sequence=AAH07686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH11828.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
3 PDB 3D structures from and Proteopedia for CAPN2:
1KFU (3D)        1KFX (3D)        2NQA (3D)    
Secondary accessions: A6NDG7 B7ZA96 E7ES58 Q16738 Q6PJT3 Q8WU26 Q9HBB1
Alternative splicing: 2 isoforms:  P17655-1   P17655-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAPN2: NX_P17655

Explore proteomics data for CAPN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17655

  • 4/32 DME Specific Peptides for CAPN2 (P17655) (see all 32)
     IVARFAD  GATRTDI  YEALSGG  GQTNIHL 

    CAPN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAPN2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139540.1  NP_001739.2  

    ENSEMBL proteins: 
     ENSP00000399949   ENSP00000295006   ENSP00000413158  

    Human Recombinant Protein Products for CAPN2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CAPN2
    OriGene Protein Over-expression Lysate for CAPN2
    OriGene MassSpec for CAPN2 
    OriGene Custom Protein Services for CAPN2
    GenScript Custom Purified and Recombinant Proteins Services for CAPN2
    Novus Biologicals CAPN2 Protein
    Novus Biologicals CAPN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CAPN2
    Cloud-Clone Corp. Proteins for CAPN2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    CAPN2 for ontologies           About GeneDecksing



    CAPN2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAPN2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CAPN2  (calpain 2)
    OriGene Antibodies for CAPN2
    OriGene Custom Antibody Services for CAPN2
    GenScript Custom Superior Antibodies Services for CAPN2
    Novus Biologicals CAPN2 Antibodies
    Abcam antibodies for CAPN2
    Cloud-Clone Corp. Antibodies for CAPN2 
    ThermoFisher Antibody for CAPN2
    LSBio Antibodies in human, mouse, rat for CAPN2 

    Assay Products for CAPN2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAPN2
    Browse R&D Systems for biochemical assays
    GenScript CAPN2-Activity-based Protease Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAPN2 
    Cloud-Clone Corp. CLIAs for CAPN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5/8 InterPro protein domains (see all 8):
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR001300 Peptidase_C2_calpain_cat
     IPR018247 EF_Hand_1_Ca_BS
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry P17655

    ProtoNet protein and cluster: P17655

    1 Blocks protein domain: IPB001300 Calpain cysteine protease (C2) family signature

    UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 3 EF-hand domains


    CAPN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAN2_HUMAN, P17655
    Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved
    in cytoskeletal remodeling and signal transduction
    Catalytic activity: Broad endopeptidase specificity
    Enzyme regulation: Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin

         Genatlas biochemistry entry for CAPN2:
    calpain,class A,large polypeptide L2,calcium dependent neutral cysteine proteinase,papain superfamily,m type

         Enzyme Numbers (IUBMB): EC 3.4.22.531 2 EC 3.4.222

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI10639123
    GO:0008092cytoskeletal protein binding IEA--
    GO:0008233peptidase activity ----
         
    CAPN2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CAPN2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Capn2):
     cardiovascular system  embryogenesis  mortality/aging  normal  other 

    CAPN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CAPN2: Capn2tm1Tcs Capn2tm1Pag

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAPN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAPN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPN2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPN2 (see all 10):
    hsa-miR-3910 hsa-miR-137 hsa-miR-196a* hsa-miR-621 hsa-miR-124 hsa-miR-889 hsa-miR-1264 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidCAPN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAPN2
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    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CAPN2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for CAPN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CAPN2 (NM_001146068)
    Sino Biological Human cDNA Clone for CAPN2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN2
    Sirion Biotech Customized lentivirus for stable overexpression of CAPN2 
                         Customized lentivirus expression plasmids for stable overexpression of CAPN2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CAPN2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAPN2 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal adhesion0.64
    Integrin-mediated cell adhesion0.38
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    3DREAM Repression and Dynorphin Expression
    nNOS Signaling in Skeletal Muscle0.37
    Calpain Protease Regulates Cellular Mechanics0.31
    Caspase Cascade0.36
    4Integrin Pathway
    FAK1 Signaling0.67
    5Rho Family GTPases
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CAPN2
        Cytoskeleton remodeling FAK signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAPN2 (see all 6)
        Caspase Cascade
    Calcium Mediated T-Cell Apoptosis
    ERK Signaling
    Calpain Protease Regulates Cellular Mechanics
    FAK1 Signaling

    2 Cell Signaling Technology (CST) Pathways for CAPN2
        Neuroscience
    Protein Stability

    1 Tocris Bioscience Pathway for CAPN2
        Apoptosis Pathway

    1 GeneGo (Thomson Reuters) Pathway for CAPN2
        Cytoskeleton remodeling FAK signaling

    4 BioSystems Pathways for CAPN2
        Integrin-mediated cell adhesion
    Alzheimers Disease
    ErbB1 downstream signaling
    Signaling events mediated by focal adhesion kinase



    4         Kegg Pathways  (Kegg details for CAPN2):
        Protein processing in endoplasmic reticulum
    Apoptosis
    Focal adhesion
    Alzheimer's disease


    CAPN2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAPN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/30 Interacting proteins for CAPN2 (P176551, 2, 3 ENSP000002950064) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPNS1P046321, 2, 3, ENSP000002465334EBI-1028956,EBI-711828 MINT-6549073 MINT-25053 I2D: score=9 STRING: ENSP00000246533
    NMT1P304192, 3, ENSP000002589604MINT-1795337 I2D: score=2 STRING: ENSP00000258960
    TNS1Q9HBL02, 3, ENSP000001718874MINT-8216416 I2D: score=2 STRING: ENSP00000171887
    CASTP208102, 3, ENSP000003791584MINT-6549073 I2D: score=1 STRING: ENSP00000379158
    PTPN1P180312, 3, ENSP000003606834MINT-6793394 I2D: score=4 STRING: ENSP00000360683
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001824blastocyst development IEA--
    GO:0006508proteolysis IEA--
    GO:0007520myoblast fusion IEA--
    GO:0016540protein autoprocessing IEA--

    CAPN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAPN2 for compounds           About GeneDecksing

    EMD Millipore small molecules for CAPN2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CAPN2

    Compounds for CAPN2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    PD 150606Cell permeable calpain inhibitor[179528-45-1]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/24 Novoseek inferred chemical compound relationships for CAPN2 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calpeptin 84.6 5 8158145 (2), 9514420 (2), 8474564 (1)
    pd150606 73.8 2 8692879 (1)
    cysteine 71.1 21 12014988 (1), 14711513 (1), 10666632 (1), 14656436 (1) (see all 20)
    e 64d 57.2 2 17301064 (1), 11264351 (1)
    calcium 55.9 89 8739157 (4), 14656436 (3), 14993287 (3), 20089917 (3) (see all 38)
    deae-cellulose 39 3 1548485 (1), 8347679 (1)
    leupeptin 35.5 3 9514420 (2), 8474564 (1)
    ritonavir 24.5 3 14555228 (2), 15629450 (1)
    serine 21.4 3 8568927 (1), 11102442 (1), 9514420 (1)
    dithiothreitol 20.5 2 10942731 (1), 8907176 (1)

    Search CenterWatch for drugs/clinical trials and news about CAPN2 / CAN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAPN2 gene (2 alternative transcripts): 
    NM_001146068.1  NM_001748.4  

    Unigene Cluster for CAPN2:

    Calpain 2, (m/II) large subunit
    Hs.350899  [show with all ESTs]
    Unigene Representative Sequence: AK124751
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434648 ENST00000295006(uc001hob.4) ENST00000483579 ENST00000480581
    ENST00000474026(uc001hoc.3) ENST00000487223 ENST00000492565 ENST00000472601
    ENST00000498027 ENST00000492664 ENST00000463997 ENST00000433674(uc010puy.2)


    miRNA
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    hsa-miR-3910 hsa-miR-137 hsa-miR-196a* hsa-miR-621 hsa-miR-124 hsa-miR-889 hsa-miR-1264 hsa-miR-506
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN2
    Sirion Biotech Customized lentivirus for stable overexpression of CAPN2 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN2

    Additional mRNA sequence: 

    AB209855.1 AF261089.1 AK023851.1 AK055046.1 AK056838.1 AK097247.1 AK124751.1 AK297800.1 
    AK303952.1 AK315179.1 AK316211.1 BC007686.2 BC011828.2 BC021303.2 M23254.1 

    24/35 DOTS entries (see all 35):

    DT.448482  DT.95270281  DT.92451372  DT.100666812  DT.92451361  DT.75156340  DT.86852739  DT.95270282 
    DT.40227680  DT.100714757  DT.100741239  DT.121366908  DT.121366935  DT.121366957  DT.92451373  DT.100741255 
    DT.100863941  DT.121366903  DT.121366947  DT.91698379  DT.92451344  DT.95270275  DT.95270280  DT.100741234 

    24/562 AceView cDNA sequences (see all 562):

    BM314210 BI224503 BF593235 BP375828 R77216 CB143105 CB150654 BM980137 
    CB139837 BQ670152 BG679184 CB268553 BU175325 AI935986 CD723885 BQ688863 
    T59704 BU191273 BF433643 CA436209 R77217 BM787564 BG574112 CA424712 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a ·
    SP1:                                                                                      -                             -     -           -     -               
    SP2:                                                                                      -                                               -     -               
    SP3:                                            -                                                                                                               
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 19b · 19c ^ 20a · 20b
    SP1:  -     -               
    SP2:  -     -               
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CAPN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPN2 expression in normal human tissues (normalized intensities)      CAPN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTAGAGG
    CAPN2 Expression
    About this image


    CAPN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Spinous Keratinocytes Stratified Epidermis
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium

    See CAPN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPN2

    SOURCE GeneReport for Unigene cluster: Hs.350899

    UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including CAPN2: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Focal Adhesions in human mouse rat
              Necrosis in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CAPN2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capn21 , 5 calpain 21, 5 87.67(n)1
    94(a)1
      1 (84.93 cM)5
    123341  NM_009794.31  NP_033924.21 
     1824672595 
    chicken
    (Gallus gallus)
    Aves CAPN21 calpain 2, (m/II) large subunit 77.95(n)
    81.29(a)
      395963  NM_205080.1  NP_990411.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAPN26
    calpain 2, (m/II) large subunit
    82(a)
    1 ↔ 1
    1(245070312-245129928)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684742 hypothetical protein MGC68474 74.57(n)    BC063733.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054941.12   -- 74.62(n)   393417  BC054941.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CalpA3 actin cytoskeleton organization and
    biogenesis more
    49(a)
    (best of 3)
      56D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea clp-73   -- 45(a)
    (best of 3)
      IV(1435632-1445971)   --


    ENSEMBL Gene Tree for CAPN2 (if available)
    TreeFam Gene Tree for CAPN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAPN2 gene
    CAPN62  CAPN82  CAPN142  CAPNS12  CAPN132  CAPN12  CAPN52  CAPN92  
    CAPNS22  CAPN32  CAPN122  CAPN112  CAPN102  
    14 SIMAP similar genes for CAPN2 using alignment to 2 protein entries:     CAN2_HUMAN (see all proteins):
    CAPN1    CAPN8    CAPN11    CAPNS1    CAPN3    CAPN9
    CAPN14    CAPNS2    CAPN12    CAPN5    SRI    GCA
    CAPN6    CAPN13

    CAPN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1812 SNPs in CAPN2 are shown (see all 1812)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857257721,2
    --223887594(+) GTTTAC/TTCTTA 1 -- us2k10--------
    rs1909706691,2
    --223887646(+) GCATTC/TCCACC 1 -- us2k10--------
    rs803523341,2
    C--223887850(+) ACTCCC/TAGAAC 1 -- us2k10--------
    rs46538361,2
    C,F,A--223887895(-) TTGGCC/GCCCTG 1 -- us2k112Minor allele frequency- G:0.38NA WA CSA EA 375
    rs1830662941,2
    C--223888074(+) AGCACC/TCACAA 1 -- us2k10--------
    rs3756811691,2
    C--223888104(+) GCCCC-/AGAGAGA 1 -- us2k10--------
    rs1141139151,2
    F--223888298(+) TAGTGG/CATAGT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs759588591,2
    C,F--223888357(+) CACAGG/AGCCCA 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs758582391,2
    C--223888558(+) GCTAG-/CCGGGG 1 -- us2k10--------
    rs57813361,2
    C--223888559(-) TCCCC-/GCTAGC 1 -- us2k12Minor allele frequency- G:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for CAPN2 (223889295 - 223963720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for CAPN2 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv274539CNV Insertion20981092
    nsv4698CNV Insertion18451855
    esv271309CNV Insertion20981092
    nsv520609CNV Loss19592680
    nsv521758CNV Loss19592680
    nsv437346CNV Loss16327808
    esv34082CNV Loss18971310
    nsv832681CNV Gain17160897
    nsv873213CNV Gain21882294
    essv335CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114230    OMIM disorders: --

    20/42 diseases for CAPN2 (see all 42):    About MalaCards
    muscular dystrophy    primary hyperparathyroidism    gastric cancer    duchenne muscular dystrophy
    limb-girdle muscular dystrophy    alzheimer's disease    hyperparathyroidism    vaginitis
    cataract    chondrosarcoma    osteoarthritis    parkinson's disease
    muscular atrophy    basal cell carcinoma    aortic aneurysm    esophageal adenocarcinoma
    myopathy    acute leukemia    malaria    hepatocellular carcinoma


    CAPN2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/20 Novoseek inferred disease relationships for CAPN2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lgmd2a 67.3 1 12843569 (1)
    muscular dystrophies 45.2 1 11371436 (1)
    cataract 30.4 1 7821381 (1)
    muscular dystrophy duchenne 18.2 4 9498100 (1), 9798335 (1)
    atrophy 14.6 1 20513182 (1)
    alzheimers disease 11.2 4 9654354 (2), 8622780 (1)
    cancer 4.41 2 16361262 (1), 16982626 (1)
    necrosis 0 3 15501405 (1), 16574073 (1), 10639123 (1)
    cancer lung 0 7 16361262 (2), 16982626 (2), 15471877 (2)
    neurodegenerative diseases 0 2 8809817 (2)

    Genetic Association Database (GAD): CAPN2
    Human Genome Epidemiology (HuGE) Navigator: CAPN2 (8 documents)

    Export disorders for CAPN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPN2 gene, integrated from 9 sources (see all 312):
    (articles sorted by number of sources associating them with CAPN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease. (PubMed id 2539381)1, 2, 3 Hata A....Suzuki K. (1989)
    2. Molecular cloning of the cDNA for the large subunit of the high-Ca2+- requiring form of human Ca2+-activated neutral protease. (PubMed id 2852952)1, 2, 3 Imajoh S....Suzuki K. (1988)
    3. The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. (PubMed id 10639123)1, 2, 9 Strobl S.... Bode W. (2000)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    8. Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. (PubMed id 18568448)1, 4 Mizuta I....Toda T. (2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 824 HGNC: 1479 AceView: CAPN2 Ensembl:ENSG00000162909 euGenes: HUgn824
    ECgene: CAPN2 Kegg: 824 H-InvDB: CAPN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPN2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/capn2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAPN2 gene:
    Search GeneIP for patents involving CAPN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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