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CAPN2 Gene

protein-coding   GIFtS: 70
GCID: GC01P223890

Calpain 2, (M/II) Large Subunit

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calpain 2, (M/II) Large Subunit1 2     CANPml2
Calcium-Activated Neutral Proteinase 22 3     Calpain 2, Large [Catalytic] Subunit2
Calpain Large Polypeptide L22 3     Calpain 2, Large Subunit2
Calpain M-Type2 3     Calpain, Large Polypeptide L22
Calpain-2 Large Subunit2 3     Calpain-2 Catalytic Subunit2
CANPL22 3     mCANP2
M-calpain2 3     millimolar-calpain2
CANP 22 3     Millimolar-calpain3
EC 3.4.22.533 8     EC 3.4.228
CANP22     

External Ids:    HGNC: 14791   Entrez Gene: 8242   Ensembl: ENSG000001629097   OMIM: 1142305   UniProtKB: P176553   

Export aliases for CAPN2 gene to outside databases

Previous GC identifers: GC01M222640 GC01M219933 GC01P220400 GC01P220874 GC01P220206 GC01P221966 GC01P194501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAPN2 Gene:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The
mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes
consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory
subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous
transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for CAPN2 Gene:
CAPN2 (calpain 2, (m/II) large subunit) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and calcium ion binding. An important paralog of this gene is CAPN6.

UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655
Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved
in cytoskeletal remodeling and signal transduction

summary for CAPN2 Gene:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

Gene Wiki entry for CAPN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAPN2 gene promoter:
         HOXA9   HOXA9B   Bach1   p53   MyoD   MIF-1   C/EBPalpha   Pax-3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPN2 promoter sequence
   Search Chromatin IP Primers for CAPN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41-q42   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41-q42

CAPN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P223890:  view genomic region     (about GC identifiers)

Start:
223,889,295 bp from pter      End:
223,963,720 bp from pter
Size:
74,426 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655 (See protein sequence)
Recommended Name: Calpain-2 catalytic subunit precursor  
Size: 700 amino acids; 79995 Da
Cofactor: Binds 7 calcium ions (By similarity)
Subunit: Forms a heterodimer with a small (regulatory) subunit (CAPNS1)
Sequence caution: Sequence=AAH07686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH11828.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
3 PDB 3D structures from and Proteopedia for CAPN2:
1KFU (3D)        1KFX (3D)        2NQA (3D)    
Secondary accessions: A6NDG7 B7ZA96 E7ES58 Q16738 Q6PJT3 Q8WU26 Q9HBB1
Alternative splicing: 2 isoforms:  P17655-1   P17655-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAPN2: NX_P17655

Explore proteomics data for CAPN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys26, Lys260, Lys476, Lys674
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CAPN2 (P17655) (see all 32)
     IVARFAD  GATRTDI  YEALSGG  GQTNIHL 


    See CAPN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139540.1  NP_001739.2  

    ENSEMBL proteins: 
     ENSP00000399949   ENSP00000295006   ENSP00000413158  

    CAPN2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CAPN2
    OriGene Protein Over-expression Lysate for CAPN2
    OriGene MassSpec for CAPN2
    OriGene Custom Protein Services for CAPN2
    GenScript Custom Purified and Recombinant Proteins Services for CAPN2
    Novus Biologicals CAPN2 Protein
    Novus Biologicals CAPN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CAPN2
    Cloud-Clone Corp. Proteins for CAPN2

     
    Search eBioscience for Proteins for CAPN2 

    CAPN2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAPN2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CAPN2  (calpain 2)
    OriGene Antibodies for CAPN2
    OriGene Custom Antibody Services for CAPN2
    Novus Biologicals CAPN2 Antibodies
    Abcam antibodies for CAPN2
    Cloud-Clone Corp. Antibodies for CAPN2
    ThermoFisher Antibody for CAPN2
    LSBio Antibodies in human, mouse, rat for CAPN2

    CAPN2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAPN2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAPN2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAPN2
    Cloud-Clone Corp. CLIAs for CAPN2
    Search eBioscience for ELISAs for CAPN2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 8):
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR001300 Peptidase_C2_calpain_cat
     IPR018247 EF_Hand_1_Ca_BS
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry P17655

    ProtoNet protein and cluster: P17655

    1 Blocks protein domain: IPB001300 Calpain cysteine protease (C2) family signature

    UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 3 EF-hand domains


    Find genes that share domains with CAPN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAN2_HUMAN, P17655
    Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved
    in cytoskeletal remodeling and signal transduction
    Catalytic activity: Broad endopeptidase specificity
    Enzyme regulation: Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin

         Genatlas biochemistry entry for CAPN2:
    calpain,class A,large polypeptide L2,calcium dependent neutral cysteine proteinase,papain superfamily,m type

         Enzyme Numbers (IUBMB): EC 3.4.22.531 2 EC 3.4.222

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity ISS--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI10639123
    GO:0008092cytoskeletal protein binding NAS12150984
    GO:0008233peptidase activity ----
         
    Find genes that share ontologies with CAPN2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CAPN2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Capn2):
     cardiovascular system  embryogenesis  mortality/aging  normal  other 

    Find genes that share phenotypes with CAPN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CAPN2: Capn2tm1Tcs Capn2tm1Pag

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAPN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPN2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAPN2:
    hsa-mir-101-3p (MIRT027353), hsa-mir-30a-5p (MIRT028659), hsa-mir-7-5p (MIRT025966)

    Block miRNA regulation of human, mouse, rat CAPN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPN2 (see all 10):
    hsa-miR-3910 hsa-miR-137 hsa-miR-196a* hsa-miR-621 hsa-miR-124 hsa-miR-889 hsa-miR-1264 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidCAPN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAPN2
    Predesigned siRNA for gene silencing in human, mouse, rat CAPN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAPN2

    Clone
    Products:
         
    OriGene clones in human, mouse for CAPN2 (see all 13)
    OriGene ORF clones in mouse, rat for CAPN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CAPN2 (NM_001146068)
    Sino Biological Human cDNA Clone for CAPN2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CAPN2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAPN2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12289) for CAPN2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAN2_HUMAN, P17655: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton2
    endoplasmic reticulum2
    mitochondrion2
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ISS--
    GO:0005783endoplasmic reticulum IDA14559243

    Find genes that share ontologies with CAPN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAPN2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3DREAM Repression and Dynorphin Expression
    nNOS Signaling in Skeletal Muscle0.37
    Calpain Protease Regulates Cellular Mechanics0.31
    Caspase Cascade0.36
    4Integrin Pathway
    FAK1 Signaling0.67
    5ERK Signaling
    ERK Signaling0.61


    Find genes that share SuperPaths with CAPN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CAPN2 (see all 6)
        Caspase Cascade
    Calcium Mediated T-Cell Apoptosis
    ERK Signaling
    Calpain Protease Regulates Cellular Mechanics
    FAK1 Signaling

    2 Cell Signaling Technology (CST) Pathways for CAPN2
        Neuroscience
    Protein Stability

    1 Tocris Bioscience Pathway for CAPN2
        Apoptosis Pathway

    1 GeneGo (Thomson Reuters) Pathway for CAPN2
        Cytoskeleton remodeling FAK signaling

    4 BioSystems Pathways for CAPN2
        Integrin-mediated cell adhesion
    Alzheimers Disease
    ErbB1 downstream signaling
    Signaling events mediated by focal adhesion kinase



    4 Kegg Pathways  (Kegg details for CAPN2):
        Protein processing in endoplasmic reticulum
    Apoptosis
    Focal adhesion
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CAPN2: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Focal Adhesions in human mouse rat
              Necrosis in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CAPN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAPN2 (P176551, 2, 3 ENSP000002950064) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPNS1P046321, 2, 3, ENSP000002465334EBI-1028956,EBI-711828 MINT-6549073 MINT-25053 I2D: score=9 STRING: ENSP00000246533
    NMT1P304192, 3, ENSP000002589604MINT-1795337 I2D: score=2 STRING: ENSP00000258960
    TNS1Q9HBL02, 3, ENSP000001718874MINT-8216416 I2D: score=2 STRING: ENSP00000171887
    CASTP208102, 3, ENSP000003791584MINT-6549073 I2D: score=1 STRING: ENSP00000379158
    PTPN1P180312, 3, ENSP000003606834MINT-6793394 I2D: score=4 STRING: ENSP00000360683
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001824blastocyst development IEA--
    GO:0006508proteolysis ISS--
    GO:0007520myoblast fusion IEA--
    GO:0016540protein autoprocessing IEA--

    Find genes that share ontologies with CAPN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CAPN2
    9 ApexBio Compounds for CAPN2     About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    Calpain Inhibitor I, ALLNA cell-permeable inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L. [110044-82-1]
    Calpain Inhibitor II, ALLMA cell-permeable inhibitor of calpain 1 and calpain 2[136632-32-1]
    CalpeptinPotent, cell-permeable inhibitor of calpain[117591-20-5]
    E-64Irriversible cysteine protease inhibitor[66701-25-5]
    MDL 28170Potent, selective inhibitor of calpain and cathepsin B[88191-84-8]
    MG-132Proteasome and calpain inhibitor[133407-82-6]
    PD 150606Selective, cell-permeable non-peptide calpain inhibitor[179528-45-1]
    Z-FA-FMKAn inhibitor of cysteine proteases, such as cathepsin B--

    Compounds for CAPN2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    PD 150606Cell permeable calpain inhibitor[179528-45-1]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for CAPN2 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calpeptin 84.6 5 8158145 (2), 9514420 (2), 8474564 (1)
    pd150606 73.8 2 8692879 (1)
    cysteine 71.1 21 12014988 (1), 14711513 (1), 10666632 (1), 14656436 (1) (see all 20)
    e 64d 57.2 2 17301064 (1), 11264351 (1)
    calcium 55.9 89 8739157 (4), 14656436 (3), 14993287 (3), 20089917 (3) (see all 38)
    deae-cellulose 39 3 1548485 (1), 8347679 (1)
    leupeptin 35.5 3 9514420 (2), 8474564 (1)
    ritonavir 24.5 3 14555228 (2), 15629450 (1)
    serine 21.4 3 8568927 (1), 11102442 (1), 9514420 (1)
    dithiothreitol 20.5 2 10942731 (1), 8907176 (1)



    Find genes that share compounds with CAPN2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAPN2 gene (2 alternative transcripts): 
    NM_001146068.1  NM_001748.4  

    Unigene Cluster for CAPN2:

    Calpain 2, (m/II) large subunit
    Hs.350899  [show with all ESTs]
    Unigene Representative Sequence: AK124751
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434648 ENST00000295006(uc001hob.4) ENST00000483579 ENST00000480581
    ENST00000474026(uc001hoc.3) ENST00000487223 ENST00000492565 ENST00000472601
    ENST00000498027 ENST00000492664 ENST00000463997 ENST00000433674(uc010puy.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat CAPN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAPN2 (see all 10):
    hsa-miR-3910 hsa-miR-137 hsa-miR-196a* hsa-miR-621 hsa-miR-124 hsa-miR-889 hsa-miR-1264 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidCAPN2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CAPN2
    Predesigned siRNA for gene silencing in human, mouse, rat CAPN2
    Clone
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    OriGene clones in human, mouse for CAPN2 (see all 13)
    OriGene ORF clones in mouse, rat for CAPN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CAPN2 (NM_001146068)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN2
    Primer
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    OriGene qPCR primer pairs and template standards for CAPN2
    OriGene qSTAR qPCR primer pairs in human, mouse for CAPN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAPN2
      QuantiTect SYBR Green Assays in human, mouse, rat CAPN2
      QuantiFast Probe-based Assays in human, mouse, rat CAPN2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12289) for CAPN2 

    Additional mRNA sequence: 

    AB209855.1 AF261089.1 AK023851.1 AK055046.1 AK056838.1 AK097247.1 AK124751.1 AK297800.1 
    AK303952.1 AK315179.1 AK316211.1 BC007686.2 BC011828.2 BC021303.2 M23254.1 

    Selected DOTS entries (see all 35):

    DT.448482  DT.95270281  DT.92451372  DT.100666812  DT.92451361  DT.75156340  DT.86852739  DT.95270282 
    DT.40227680  DT.100714757  DT.100741239  DT.121366908  DT.121366935  DT.121366957  DT.92451373  DT.100741255 
    DT.100863941  DT.121366903  DT.121366947  DT.91698379  DT.92451344  DT.95270275  DT.95270280  DT.100741234 

    Selected AceView cDNA sequences (see all 562):

    BC007686 F10932 BF433643 AI635094 BQ670152 CA424712 BM556129 BP375828 
    BQ929704 BE315174 BG574112 BQ272483 CB216225 AW071012 CA436209 BC011828 
    BE795366 BE856165 CB147918 AK023851 BU684527 BU183591 BM980137 R77216 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAPN2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a ·
    SP1:                                                                                      -                             -     -           -     -               
    SP2:                                                                                      -                                               -     -               
    SP3:                                            -                                                                                                               
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 19b · 19c ^ 20a · 20b
    SP1:  -     -               
    SP2:  -     -               
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CAPN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CAPN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTAGAGG
    CAPN2 Expression
    About this image


    CAPN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Epithelial Cells
             Spinous Keratinocytes Stratified Epidermis
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
     
     Brain (Nervous System)
             Cerebral Cortex
    CAPN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.350899

    UniProtKB/Swiss-Prot: CAN2_HUMAN, P17655
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CAPN2: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Focal Adhesions in human mouse rat
              Necrosis in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CAPN2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capn21 , 5 calpain 21, 5 87.67(n)1
    94(a)1
      1 (84.93 cM)5
    123341  NM_009794.31  NP_033924.21 
     1824672595 
    chicken
    (Gallus gallus)
    Aves CAPN21 calpain 2, (m/II) large subunit 77.95(n)
    81.29(a)
      395963  NM_205080.1  NP_990411.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAPN26
    calpain 2, (m/II) large subunit
    82(a)
    1 ↔ 1
    1(245070312-245129928)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684742 hypothetical protein MGC68474 74.57(n)    BC063733.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054941.12   -- 74.62(n)   393417  BC054941.1 


    ENSEMBL Gene Tree for CAPN2 (if available)
    TreeFam Gene Tree for CAPN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAPN2 gene
    CAPN62  CAPN82  CAPN142  CAPNS12  CAPN132  CAPN12  CAPN52  CAPN92  
    CAPN32  CAPNS22  CAPN122  CAPN112  CAPN102  
    14 SIMAP similar genes for CAPN2 using alignment to 2 protein entries:     CAN2_HUMAN (see all proteins):
    CAPN1    CAPN8    CAPN11    CAPN3    CAPNS1    CAPN9
    CAPN14    CAPNS2    CAPN12    CAPN5    SRI    GCA
    CAPN6    CAPN13

    Find genes that share paralogs with CAPN2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAPN2 (see all 1812)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857257721,2
    --223887594(+) GTTTAC/TTCTTA 1 -- us2k10--------
    rs1909706691,2
    --223887646(+) GCATTC/TCCACC 1 -- us2k10--------
    rs803523341,2
    C--223887850(+) ACTCCC/TAGAAC 1 -- us2k10--------
    rs46538361,2
    C,F,A--223887895(-) TTGGCC/GCCCTG 1 -- us2k112Minor allele frequency- G:0.38NA WA CSA EA 375
    rs1830662941,2
    C--223888074(+) AGCACC/TCACAA 1 -- us2k10--------
    rs3756811691,2
    C--223888104(+) GCCCC-/AGAGAGA 1 -- us2k10--------
    rs1141139151,2
    F--223888298(+) TAGTGG/CATAGT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs759588591,2
    C,F--223888357(+) CACAGG/AGCCCA 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs758582391,2
    C--223888558(+) GCTAG-/CCGGGG 1 -- us2k10--------
    rs57813361,2
    C--223888559(-) TCCCC-/GCTAGC 1 -- us2k12Minor allele frequency- G:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for CAPN2 (223889295 - 223963720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CAPN2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274539CNV Insertion20981092
    nsv4698CNV Insertion18451855
    esv271309CNV Insertion20981092
    nsv520609CNV Loss19592680
    nsv521758CNV Loss19592680
    nsv437346CNV Loss16327808
    esv34082CNV Loss18971310
    nsv832681CNV Gain17160897
    nsv873213CNV Gain21882294
    essv335CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAPN2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114230    OMIM disorders: --


    Find genes that share disorders with CAPN2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CAPN2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lgmd2a 67.3 1 12843569 (1)
    muscular dystrophies 45.2 1 11371436 (1)
    cataract 30.4 1 7821381 (1)
    muscular dystrophy duchenne 18.2 4 9498100 (1), 9798335 (1)
    atrophy 14.6 1 20513182 (1)
    alzheimers disease 11.2 4 9654354 (2), 8622780 (1)
    cancer 4.41 2 16361262 (1), 16982626 (1)
    necrosis 0 3 15501405 (1), 16574073 (1), 10639123 (1)
    cancer lung 0 7 16361262 (2), 16982626 (2), 15471877 (2)
    neurodegenerative diseases 0 2 8809817 (2)

    Genetic Association Database (GAD): CAPN2
    Human Genome Epidemiology (HuGE) Navigator: CAPN2 (8 documents)

    Export disorders for CAPN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAPN2 gene, integrated from 10 sources (see all 318):
    (articles sorted by number of sources associating them with CAPN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium- dependent protease. (PubMed id 2539381)1, 2, 3 Hata A.... Suzuki K. (J. Biol. Chem. 1989)
    2. Molecular cloning of the cDNA for the large subunit of the high-Ca2+- requiring form of human Ca2+-activated neutral protease. (PubMed id 2852952)1, 2, 3 Imajoh S....Suzuki K. (Biochemistry 1988)
    3. The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. (PubMed id 10639123)1, 2, 9 Strobl S.... Bode W. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    8. Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. (PubMed id 18568448)1, 4 Mizuta I....Toda T. (Hum. Genet. 2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 824 HGNC: 1479 AceView: CAPN2 Ensembl:ENSG00000162909 euGenes: HUgn824
    ECgene: CAPN2 Kegg: 824 H-InvDB: CAPN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAPN2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/capn2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAPN2 gene:
    Search GeneIP for patents involving CAPN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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