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Aliases for CAPN2 Gene

Aliases for CAPN2 Gene

  • Calpain 2 2 3
  • Calpain 2, (M/II) Large Subunit 2 3 5
  • Calcium-Activated Neutral Proteinase 2 3 4
  • Calpain Large Polypeptide L2 3 4
  • Calpain-2 Large Subunit 3 4
  • Millimolar-Calpain 3 4
  • Calpain M-Type 3 4
  • EC 3.4.22.53 4 63
  • M-Calpain 3 4
  • CANP 2 3 4
  • CANPL2 3 4
  • Calpain 2, Large [Catalytic] Subunit 3
  • Calpain, Large Polypeptide L2 3
  • Calpain 2, Large Subunit 3
  • EC 3.4.22 63
  • CANPml 3
  • CANP2 3
  • MCANP 3

External Ids for CAPN2 Gene

Previous GeneCards Identifiers for CAPN2 Gene

  • GC01M222640
  • GC01M219933
  • GC01P220400
  • GC01P220874
  • GC01P220206
  • GC01P221966
  • GC01P223890
  • GC01P194501

Summaries for CAPN2 Gene

Entrez Gene Summary for CAPN2 Gene

  • The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for CAPN2 Gene

CAPN2 (Calpain 2) is a Protein Coding gene. Diseases associated with CAPN2 include duchenne muscular dystrophy and calpainopathy. Among its related pathways are Alzheimer's disease and Apoptosis Modulation and Signaling. GO annotations related to this gene include calcium ion binding and peptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN2 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at Arg-226 (PubMed:17650508).

Tocris Summary for CAPN2 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Gene Wiki entry for CAPN2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN2 Gene

Genomics for CAPN2 Gene

Regulatory Elements for CAPN2 Gene

Enhancers for CAPN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAPN2 on UCSC Golden Path with GeneCards custom track

Promoters for CAPN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAPN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPN2 Gene

Chromosome:
1
Start:
223,701,593 bp from pter
End:
223,776,018 bp from pter
Size:
74,426 bases
Orientation:
Plus strand

Genomic View for CAPN2 Gene

Genes around CAPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN2 Gene

Proteins for CAPN2 Gene

  • Protein details for CAPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17655-CAN2_HUMAN
    Recommended name:
    Calpain-2 catalytic subunit
    Protein Accession:
    P17655
    Secondary Accessions:
    • A6NDG7
    • B7ZA96
    • E7ES58
    • Q16738
    • Q6PJT3
    • Q8WU26
    • Q9HBB1

    Protein attributes for CAPN2 Gene

    Size:
    700 amino acids
    Molecular mass:
    79995 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
    SequenceCaution:
    • Sequence=AAH07686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH11828.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAPN2 Gene

    Alternative splice isoforms for CAPN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPN2 Gene

Proteomics data for CAPN2 Gene at MOPED

Post-translational modifications for CAPN2 Gene

  • Ubiquitination at Lys 26, Lys 260, Lys 476, and Lys 674
  • Modification sites at PhosphoSitePlus

Other Protein References for CAPN2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAPN2 (CAPN2)

Domains & Families for CAPN2 Gene

Gene Families for CAPN2 Gene

Suggested Antigen Peptide Sequences for CAPN2 Gene

Graphical View of Domain Structure for InterPro Entry

P17655

UniProtKB/Swiss-Prot:

CAN2_HUMAN :
  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
Domain:
  • Contains 1 calpain catalytic domain.
  • Contains 3 EF-hand domains.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN2: view

Function for CAPN2 Gene

Molecular function for CAPN2 Gene

GENATLAS Biochemistry:
calpain,class A,large polypeptide L2,calcium dependent neutral cysteine proteinase,papain superfamily,m type
UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at Arg-226 (PubMed:17650508).

Enzyme Numbers (IUBMB) for CAPN2 Gene

genes like me logo Genes that share phenotypes with CAPN2: view

Animal Models for CAPN2 Gene

MGI Knock Outs for CAPN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPN2

miRNA for CAPN2 Gene

miRTarBase miRNAs that target CAPN2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN2 Gene

Localization for CAPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN2 Gene

Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN2 Gene COMPARTMENTS Subcellular localization image for CAPN2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
lysosome 3
nucleus 3
vacuole 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CAPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS --
GO:0005925 focal adhesion IDA 21423176
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with CAPN2: view

Pathways & Interactions for CAPN2 Gene

genes like me logo Genes that share pathways with CAPN2: view

Pathways by source for CAPN2 Gene

SIGNOR curated interactions for CAPN2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CAPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0016540 protein autoprocessing IEA --
genes like me logo Genes that share ontologies with CAPN2: view

Drugs & Compounds for CAPN2 Gene

(15) Drugs for CAPN2 Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0
calcium Nutra 0
Calpain Inhibitor I, ALLN Pharma Calpain I/II/ B/L inhibitor 0
Calpain Inhibitor II, ALLM Pharma Calpain inhibitor 0

(15) Additional Compounds for CAPN2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Calpeptin
117591-20-5
Acetyl-Calpastatin (184-210) (human)
123714-50-1
MG 132
133407-82-6
PD 150606
179528-45-1

(5) Tocris Compounds for CAPN2 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
PD 150606 Cell permeable calpain inhibitor 179528-45-1

(3) ApexBio Compounds for CAPN2 Gene

Compound Action Cas Number
Calpain Inhibitor I, ALLN Calpain I/II/ B/L inhibitor 110044-82-1
Calpain Inhibitor II, ALLM Calpain inhibitor 136632-32-1
MDL 28170 Calpain and cathepsin B inhibitor, selective 88191-84-8
genes like me logo Genes that share compounds with CAPN2: view

Drug Products

Transcripts for CAPN2 Gene

Unigene Clusters for CAPN2 Gene

Calpain 2, (m/II) large subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a ·
SP1: - - - - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:

ExUns: 19b · 19c ^ 20a · 20b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for CAPN2 Gene

GeneLoc Exon Structure for
CAPN2
ECgene alternative splicing isoforms for
CAPN2

Expression for CAPN2 Gene

mRNA expression in normal human tissues for CAPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAPN2 Gene

This gene is overexpressed in Breast (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPN2 Gene



SOURCE GeneReport for Unigene cluster for CAPN2 Gene Hs.350899

mRNA Expression by UniProt/SwissProt for CAPN2 Gene

P17655-CAN2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with CAPN2: view

Protein tissue co-expression partners for CAPN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CAPN2 Gene

Orthologs for CAPN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAPN2 35
  • 90.38 (n)
  • 94.71 (a)
CAPN2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN2 35
  • 86.37 (n)
  • 94.04 (a)
CAPN2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capn2 35
  • 87.67 (n)
  • 94 (a)
Capn2 16
Capn2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAPN2 35
  • 99.67 (n)
  • 100 (a)
CAPN2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capn2 35
  • 88.1 (n)
  • 93.86 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPN2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPN2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPN2 35
  • 77.95 (n)
  • 81.29 (a)
CAPN2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPN2 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn2.2 35
  • 71.44 (n)
  • 72.96 (a)
Str.4897 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68474 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
capn2l 35
  • 66.1 (n)
  • 69.14 (a)
CAPN2 (3 of 4) 36
  • 69 (a)
OneToMany
capn2a 36
  • 67 (a)
OneToMany
capn2b 36
  • 65 (a)
OneToMany
capn2l 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5054 35
fruit fly
(Drosophila melanogaster)
Insecta CalpA 37
  • 49 (a)
CalpB 37
  • 44 (a)
CalpC 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea clp-3 37
  • 37 (a)
clp-6 37
  • 44 (a)
clp-7 37
  • 45 (a)
Species with no ortholog for CAPN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN2 Gene

ENSEMBL:
Gene Tree for CAPN2 (if available)
TreeFam:
Gene Tree for CAPN2 (if available)

Paralogs for CAPN2 Gene

(14) SIMAP similar genes for CAPN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CAPN2: view

Variants for CAPN2 Gene

Sequence variations from dbSNP and Humsavar for CAPN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs25655 - 223,712,706(+) CACGA(C/G)AGGGC intron-variant, reference, missense
rs17599 - 223,766,378(+) ATATC(A/C/T)AGTCA reference, missense
rs2230083 - 223,712,842(+) ACTCC(A/G)GCAAA intron-variant, reference, missense
rs9804140 - 223,759,379(+) CTTCA(A/G)GCTGC reference, missense
rs28370127 - 223,761,612(+) ATCTT(A/C/G)AAGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CAPN2 Gene

Variant ID Type Subtype PubMed ID
nsv832681 CNV Gain 17160897
esv34082 CNV Loss 18971310
nsv873213 CNV Gain 21882294
nsv437346 CNV Loss 16327808
esv274539 CNV Insertion 20981092
esv271309 CNV Insertion 20981092
nsv520609 CNV Loss 19592680
nsv521758 CNV Loss 19592680
essv335 CNV CNV 17122850
dgv182e1 CNV Complex 17122850
nsv4698 CNV Insertion 18451855

Variation tolerance for CAPN2 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.43; 92.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN2 Gene

HapMap Linkage Disequilibrium report
CAPN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN2 Gene

Disorders for CAPN2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CAPN2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
duchenne muscular dystrophy
  • muscular dystrophy, duchenne
calpainopathy
  • limb-girdle muscular dystrophy type 2a
- elite association - COSMIC cancer census association via MalaCards
Search CAPN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAPN2

Genetic Association Database (GAD)
CAPN2
Human Genome Epidemiology (HuGE) Navigator
CAPN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPN2
genes like me logo Genes that share disorders with CAPN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAPN2 Gene

Publications for CAPN2 Gene

  1. Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium- dependent protease. (PMID: 2539381) Hata A. … Suzuki K. (J. Biol. Chem. 1989) 2 3 4 67
  2. m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions. (PMID: 19752040) Miyazaki T. … Ohata H. (Cardiovasc. Res. 2010) 3 23
  3. TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase. (PMID: 20070945) Su L.T. … Runnels L.W. (J. Mol. Biol. 2010) 3 23
  4. G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage. (PMID: 17261541) Maehara H. … Shimizu K. (J. Biochem. 2007) 3 23
  5. Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity. (PMID: 17596297) Miyazaki T. … Ohata H. (Am. J. Physiol., Cell Physiol. 2007) 3 23

Products for CAPN2 Gene

  • Addgene plasmids for CAPN2

Sources for CAPN2 Gene

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