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Aliases for CAPN15 Gene

Aliases for CAPN15 Gene

  • Calpain 15 2 3 5
  • Small Optic Lobes Homolog 3 4
  • SOLH 3 4
  • Small Optic Lobes (Drosophila) Homolog 2
  • Small Optic Lobes Homolog (Drosophila) 2
  • EC 3.4.22.54 63
  • EC 3.4.22.- 4
  • EC 3.4.22 63

External Ids for CAPN15 Gene

Previous HGNC Symbols for CAPN15 Gene

  • SOLH

Previous GeneCards Identifiers for CAPN15 Gene

  • GC16P000578

Summaries for CAPN15 Gene

Entrez Gene Summary for CAPN15 Gene

  • This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPN15 Gene

CAPN15 (Calpain 15) is a Protein Coding gene. Diseases associated with CAPN15 include spastic hemiplegia and polyradiculopathy. Among its related pathways are Degradation of the extracellular matrix. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and cysteine-type peptidase activity. An important paralog of this gene is CAPN7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN15 Gene

Genomics for CAPN15 Gene

Regulatory Elements for CAPN15 Gene

Promoters for CAPN15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAPN15 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPN15 Gene

Chromosome:
16
Start:
527,717 bp from pter
End:
554,636 bp from pter
Size:
26,920 bases
Orientation:
Plus strand

Genomic View for CAPN15 Gene

Genes around CAPN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN15 Gene

Proteins for CAPN15 Gene

  • Protein details for CAPN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75808-CAN15_HUMAN
    Recommended name:
    Calpain-15
    Protein Accession:
    O75808
    Secondary Accessions:
    • B1B1M4
    • Q2KHS2
    • Q8WTY9
    • Q9BUW0

    Protein attributes for CAPN15 Gene

    Size:
    1086 amino acids
    Molecular mass:
    117314 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAPN15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPN15 Gene

Proteomics data for CAPN15 Gene at MOPED

Selected DME Specific Peptides for CAPN15 Gene

Post-translational modifications for CAPN15 Gene

  • Ubiquitination at Lys 32, Lys 348, Lys 686, Lys 791, Lys 1053, and Lys 1066
  • Modification sites at PhosphoSitePlus

Other Protein References for CAPN15 Gene

Domains & Families for CAPN15 Gene

Gene Families for CAPN15 Gene

Protein Domains for CAPN15 Gene

Suggested Antigen Peptide Sequences for CAPN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75808

UniProtKB/Swiss-Prot:

CAN15_HUMAN :
  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
  • Contains 5 RanBP2-type zinc fingers.
Domain:
  • Contains 1 calpain catalytic domain.
Family:
  • Belongs to the peptidase C2 family.
Similarity:
  • Contains 5 RanBP2-type zinc fingers.
genes like me logo Genes that share domains with CAPN15: view

Function for CAPN15 Gene

Enzyme Numbers (IUBMB) for CAPN15 Gene

Gene Ontology (GO) - Molecular Function for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IEA --
GO:0008234 cysteine-type peptidase activity TAS 9722942
genes like me logo Genes that share ontologies with CAPN15: view
genes like me logo Genes that share phenotypes with CAPN15: view

Animal Model Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPN15 Gene

Localization for CAPN15 Gene

Gene Ontology (GO) - Cellular Components for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CAPN15 Gene

Pathways & Interactions for CAPN15 Gene

genes like me logo Genes that share pathways with CAPN15: view

Pathways by source for CAPN15 Gene

Interacting Proteins for CAPN15 Gene

Gene Ontology (GO) - Biological Process for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CAPN15: view

No data available for SIGNOR curated interactions for CAPN15 Gene

Drugs & Compounds for CAPN15 Gene

No Compound Related Data Available

Transcripts for CAPN15 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: -

Relevant External Links for CAPN15 Gene

GeneLoc Exon Structure for
CAPN15
ECgene alternative splicing isoforms for
CAPN15

Expression for CAPN15 Gene

mRNA expression in normal human tissues for CAPN15 Gene

Protein differential expression in normal tissues from HIPED for CAPN15 Gene

This gene is overexpressed in Plasma (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPN15 Gene



mRNA Expression by UniProt/SwissProt for CAPN15 Gene

O75808-CAN15_HUMAN
Tissue specificity: Widely expressed with higher expression in brain.
genes like me logo Genes that share expression patterns with CAPN15: view

Protein tissue co-expression partners for CAPN15 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CAPN15 Gene

Orthologs for CAPN15 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOLH 35
  • 98.36 (n)
  • 97.65 (a)
cow
(Bos Taurus)
Mammalia CAPN15 35
  • 86.32 (n)
  • 88.25 (a)
SOLH 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN15 36
  • 86 (a)
OneToOne
CAPN15 35
  • 87.55 (n)
  • 87.96 (a)
mouse
(Mus musculus)
Mammalia Capn15 16
Capn15 36
  • 87 (a)
OneToOne
Capn15 35
  • 83.3 (n)
  • 89.07 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPN15 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPN15 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capn15 35
  • 83.2 (n)
  • 88.53 (a)
chicken
(Gallus gallus)
Aves SOLH 35
  • 77.73 (n)
  • 78.57 (a)
CAPN15 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPN15 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn15 35
  • 69.19 (n)
  • 73.68 (a)
zebrafish
(Danio rerio)
Actinopterygii CAPN15 36
  • 64 (a)
OneToOne
solh 35
  • 68.62 (n)
  • 71.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta sol 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T11A5.6 35
  • 44.75 (n)
  • 38.89 (a)
F44F1.3 36
  • 21 (a)
OneToMany
F47F6.9 36
  • 24 (a)
OneToMany
H25P06.4 36
  • 21 (a)
OneToMany
T11A5.6 36
  • 32 (a)
OneToMany
W04A4.4 36
  • 24 (a)
OneToMany
W05G11.4 36
  • 31 (a)
OneToMany
Y53H1B.6 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3566 36
  • 43 (a)
OneToOne
Species with no ortholog for CAPN15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN15 Gene

ENSEMBL:
Gene Tree for CAPN15 (if available)
TreeFam:
Gene Tree for CAPN15 (if available)

Paralogs for CAPN15 Gene

Paralogs for CAPN15 Gene

genes like me logo Genes that share paralogs with CAPN15: view

Variants for CAPN15 Gene

Sequence variations from dbSNP and Humsavar for CAPN15 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs733972 -- 546,762(+) GGTGG(A/G)GTCCA intron-variant
rs2071923 -- 546,893(+) CGGCC(A/G/T)GCCAG reference, missense
rs2283786 -- 544,453(+) ACTGG(A/G)GCTGC intron-variant
rs3785306 -- 533,089(+) ggtgg(C/T)gggcg intron-variant
rs8053176 -- 536,971(+) GCCCC(C/T)GGCAC intron-variant, utr-variant-5-prime

Variation tolerance for CAPN15 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN15 Gene

HapMap Linkage Disequilibrium report
CAPN15
Human Gene Mutation Database (HGMD)
CAPN15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CAPN15 Gene

Disorders for CAPN15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CAPN15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spastic hemiplegia
  • congenital hemiplegia
polyradiculopathy
spastic cerebral palsy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAPN15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPN15
genes like me logo Genes that share disorders with CAPN15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAPN15 Gene

Publications for CAPN15 Gene

  1. SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia). (PMID: 9722942) Kamei M. … Campbell H.D. (Genomics 1998) 2 3 4 67
  2. Transcriptional regulatory network of SOX4 during myoblast differentiation. (PMID: 25969425) Jang S.M. … Choi K.H. (Biochem. Biophys. Res. Commun. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PMID: 23263863) Li J. … Sleiman P.M. (Hum. Mol. Genet. 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for CAPN15 Gene

Sources for CAPN15 Gene

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