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Aliases for CAPN15 Gene

Aliases for CAPN15 Gene

  • Calpain 15 2 3 5
  • Small Optic Lobes Homolog 3 4
  • SOLH 3 4
  • Small Optic Lobes (Drosophila) Homolog 2
  • Small Optic Lobes Homolog (Drosophila) 2
  • EC 58
  • EC 3.4.22.- 4
  • Calpain-15 3
  • EC 3.4.22 58

External Ids for CAPN15 Gene

Previous HGNC Symbols for CAPN15 Gene

  • SOLH

Previous GeneCards Identifiers for CAPN15 Gene

  • GC16P000578

Summaries for CAPN15 Gene

Entrez Gene Summary for CAPN15 Gene

  • This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPN15 Gene

CAPN15 (Calpain 15) is a Protein Coding gene. Diseases associated with CAPN15 include Spastic Hemiplegia and Polyradiculopathy. Among its related pathways are Degradation of the extracellular matrix. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and cysteine-type peptidase activity. An important paralog of this gene is CAPN10.

Additional gene information for CAPN15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN15 Gene

Genomics for CAPN15 Gene

Regulatory Elements for CAPN15 Gene

Enhancers for CAPN15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H000396 1.4 ENCODE dbSUPER 30.8 -127.8 -127834 7.7 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 WDR90 ENSG00000261505 WASH4P RHOT2 UBE2I NME4 WDR24 JMJD8 LUC7L CAPN15
GH16H000533 1.4 Ensembl ENCODE dbSUPER 21.4 +7.2 7185 3.2 ELF3 TBP SREBF2 ZFP64 ARID4B KLF17 DMAP1 RAD21 RARA YY1 CAPN15 PRR35 PIGQ NHLRC4 NME4 DECR2 MIR5587 GC16M000522
GH16H000137 1.3 ENCODE dbSUPER 22.5 -389.5 -389516 2.2 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 SP5 WDR90 NPRL3 JMJD8 WASH4P RHOT2 CAPN15 WDR24 AXIN1 CHTF18 ENSG00000268836
GH16H001308 1.4 ENCODE dbSUPER 20.7 +783.0 783038 5.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H000066 1.8 FANTOM5 ENCODE dbSUPER 13 -454.2 -454216 13.6 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF143 WASH4P WDR90 RHOT2 ENSG00000268836 LUC7L CHTF18 NPRL3 WDR24 RHBDF1 CAPN15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAPN15 on UCSC Golden Path with GeneCards custom track

Promoters for CAPN15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082197 183 2201 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF207

Genomic Locations for CAPN15 Gene

Genomic Locations for CAPN15 Gene
26,920 bases
Plus strand

Genomic View for CAPN15 Gene

Genes around CAPN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN15 Gene

Proteins for CAPN15 Gene

  • Protein details for CAPN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B1B1M4
    • Q2KHS2
    • Q8WTY9
    • Q9BUW0

    Protein attributes for CAPN15 Gene

    1086 amino acids
    Molecular mass:
    117314 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAPN15 Gene


neXtProt entry for CAPN15 Gene

Selected DME Specific Peptides for CAPN15 Gene


Post-translational modifications for CAPN15 Gene

  • Ubiquitination at Lys32, posLast=348348, posLast=686686, Lys791, posLast=10531053, and posLast=10661066
  • Modification sites at PhosphoSitePlus

Domains & Families for CAPN15 Gene

Gene Families for CAPN15 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CAPN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C2 family.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN15: view

Function for CAPN15 Gene

Enzyme Numbers (IUBMB) for CAPN15 Gene

Phenotypes From GWAS Catalog for CAPN15 Gene

Gene Ontology (GO) - Molecular Function for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9722942
GO:0004198 calcium-dependent cysteine-type endopeptidase activity TAS,IBA --
GO:0008233 peptidase activity TAS 9722942
GO:0008234 cysteine-type peptidase activity TAS 9722942
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CAPN15: view
genes like me logo Genes that share phenotypes with CAPN15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPN15 Gene

Localization for CAPN15 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPN15 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPN15 Gene

Pathways & Interactions for CAPN15 Gene

genes like me logo Genes that share pathways with CAPN15: view

Pathways by source for CAPN15 Gene

Gene Ontology (GO) - Biological Process for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CAPN15: view

No data available for SIGNOR curated interactions for CAPN15 Gene

Drugs & Compounds for CAPN15 Gene

No Compound Related Data Available

Transcripts for CAPN15 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d
SP5: -
SP8: -

Relevant External Links for CAPN15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPN15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPN15 Gene

Protein differential expression in normal tissues from HIPED for CAPN15 Gene

This gene is overexpressed in Plasma (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPN15 Gene

Protein tissue co-expression partners for CAPN15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPN15 Gene:


mRNA Expression by UniProt/SwissProt for CAPN15 Gene:

Tissue specificity: Widely expressed with higher expression in brain.

Evidence on tissue expression from TISSUES for CAPN15 Gene

  • Nervous system(4.5)
  • Lung(4.2)
  • Skin(2.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CAPN15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN15 Gene

Orthologs for CAPN15 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SOLH 33
  • 98.36 (n)
(Canis familiaris)
Mammalia CAPN15 33 34
  • 87.55 (n)
(Bos Taurus)
Mammalia CAPN15 33
  • 86.32 (n)
  • 86 (a)
(Mus musculus)
Mammalia Capn15 33 16 34
  • 83.3 (n)
(Rattus norvegicus)
Mammalia Capn15 33
  • 83.2 (n)
(Ornithorhynchus anatinus)
Mammalia CAPN15 34
  • 73 (a)
(Monodelphis domestica)
Mammalia CAPN15 34
  • 70 (a)
(Gallus gallus)
Aves SOLH 33
  • 77.73 (n)
CAPN15 34
  • 76 (a)
(Anolis carolinensis)
Reptilia CAPN15 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia capn15 33
  • 69.19 (n)
(Danio rerio)
Actinopterygii solh 33
  • 68.62 (n)
CAPN15 34
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta sol 34
  • 27 (a)
(Caenorhabditis elegans)
Secernentea CELE_T11A5.6 33
  • 44.75 (n)
T11A5.6 34
  • 32 (a)
W05G11.4 34
  • 31 (a)
F47F6.9 34
  • 24 (a)
W04A4.4 34
  • 24 (a)
F44F1.3 34
  • 21 (a)
H25P06.4 34
  • 21 (a)
Y53H1B.6 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3566 34
  • 43 (a)
Species where no ortholog for CAPN15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN15 Gene

Gene Tree for CAPN15 (if available)
Gene Tree for CAPN15 (if available)

Paralogs for CAPN15 Gene

Paralogs for CAPN15 Gene

genes like me logo Genes that share paralogs with CAPN15: view

Variants for CAPN15 Gene

Sequence variations from dbSNP and Humsavar for CAPN15 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000017955 -- 538,582(+) GGGGA(C/T)TCGGC intron-variant, utr-variant-5-prime
rs1000131289 -- 534,753(+) GCCAG(G/T)CCACC intron-variant, upstream-variant-2KB
rs1000266655 -- 547,727(+) TGAGT(A/G)TGCTG reference, missense
rs1000328838 -- 525,884(+) TTCCT(C/T)CTTCA upstream-variant-2KB
rs1000404210 -- 526,273(+) AGAGA(A/G)GAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAPN15 Gene

Variant ID Type Subtype PubMed ID
nsv952898 CNV deletion 24416366
nsv833114 CNV gain+loss 17160897
nsv833113 CNV loss 17160897
nsv570988 CNV gain 21841781
nsv570987 CNV loss 21841781
nsv570986 CNV loss 21841781
nsv570954 CNV loss 21841781
nsv528354 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv471064 CNV gain 18288195
nsv471063 CNV loss 18288195
nsv457304 CNV gain 19166990
nsv1160325 CNV duplication 26073780
nsv1147699 CNV deletion 26484159
nsv1140036 CNV deletion 24896259
nsv1131100 CNV deletion 24896259
nsv1129573 CNV tandem duplication 24896259
nsv1071244 CNV deletion 25765185
nsv1054426 CNV gain 25217958
nsv103268 CNV deletion 16902084
esv3637578 CNV loss 21293372
esv2750206 CNV deletion 23290073
esv2750205 CNV deletion 23290073
esv2750204 CNV deletion 23290073
esv2750203 CNV deletion 23290073
esv2750202 CNV deletion 23290073
esv2422427 CNV duplication 17116639
esv1954677 CNV deletion 18987734
esv1035948 CNV insertion 17803354

Variation tolerance for CAPN15 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN15 Gene

Disorders for CAPN15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CAPN15 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
spastic hemiplegia
  • congenital hemiplegia
spastic cerebral palsy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAPN15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CAPN15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAPN15 Gene

Publications for CAPN15 Gene

  1. SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia). (PMID: 9722942) Kamei M … Campbell HD (Genomics 1998) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 60
  4. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for CAPN15 Gene

Sources for CAPN15 Gene

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