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CAPN15 Gene

protein-coding   GIFtS: 39
GCID: GC16P000578

Calpain 15

(Previous names: small optic lobes (Drosophila) homolog, small optic lobes...)
(Previous symbol: SOLH)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calpain 151 2     calpain-152
SOLH1 2 3 5     EC 3.4.22.-3
Small Optic Lobes Homolog2 3     EC 3.4.228
Small Optic Lobes (Drosophila) Homolog1     EC 3.4.22.548
Small Optic Lobes Homolog (Drosophila)1     

External Ids:    HGNC: 111821   Entrez Gene: 66502   Ensembl: ENSG000001033267   OMIM: 6032675   UniProtKB: O758083   

Export aliases for CAPN15 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAPN15 Gene:
This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded
protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during
visual system development. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAPN15 Gene:
CAPN15 (calpain 15) is a protein-coding gene. GO annotations related to this gene include peptidase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CAPN7.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CAPN15
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPN15 promoter sequence
   Search Chromatin IP Primers for CAPN15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPN15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CAPN15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN15 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000578:  view genomic region     (about GC identifiers)

Start:
577,717 bp from pter      End:
604,636 bp from pter
Size:
26,920 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CAN15_HUMAN, O75808 (See protein sequence)
Recommended Name: Calpain-15  
Size: 1086 amino acids; 117314 Da
Secondary accessions: B1B1M4 Q2KHS2 Q8WTY9 Q9BUW0
Alternative splicing: 2 isoforms:  O75808-1   O75808-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAPN15: NX_O75808

Explore proteomics data for CAPN15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32, Lys348, Lys686, Lys791, Lys1053, Lys1066
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for CAPN15 (O75808)
     RLRNPWG  WNGSWSD 


    See CAPN15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005623.1  
    ENSEMBL proteins: 
     ENSP00000456017   ENSP00000457030   ENSP00000219611   ENSP00000457306  

    CAPN15 Human Recombinant Protein Products:

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    Novus Biologicals CAPN15 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CAPN15 

     
    antibodies-online proteins for CAPN15 (2 products) 

     
    antibodies-online peptides for CAPN15

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    antibodies-online antibodies for CAPN15 (9 products) 

    CAPN15 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CAPN15 
    antibodies-online kits for CAPN15 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001300 Peptidase_C2_calpain_cat
     IPR000169 Pept_cys_AS
     IPR022684 Calpain_cysteine_protease
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry O75808

    ProtoNet protein and cluster: O75808

    1 Blocks protein domain: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: CAN15_HUMAN, O75808
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 5 RanBP2-type zinc fingers


    Find genes that share domains with CAPN15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 3.4.22.542 EC 3.4.222 EC 3.4.22.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9722942
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IBA--
    GO:0008233peptidase activity TAS9722942
    GO:0008234cysteine-type peptidase activity TAS9722942
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CAPN15           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CAPN15:
     Decreased BPV1 E2 protein expr  Decreased cell number and incr  Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CAPN15

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAPN15:
    hsa-mir-193b-3p (MIRT041428), hsa-mir-671-5p (MIRT039266), hsa-mir-7-5p (MIRT025651), hsa-mir-98-5p (MIRT027457), hsa-let-7d-3p (MIRT038993), hsa-mir-331-3p (MIRT043476), hsa-mir-484 (MIRT042339), hsa-mir-615-3p (MIRT040095), hsa-mir-92b-3p (MIRT040710), hsa-mir-320a (MIRT044566)

    Block miRNA regulation of human, mouse, rat CAPN15 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat CAPN15

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with CAPN15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAPN15
    Interactions:

        Search GeneGlobe Interaction Network for CAPN15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CAPN15 (O758083 ENSP000002196114) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP17Q68EM73I2D: score=5 
    ARL6IP5O759153I2D: score=5 
    CTNNBL1Q8WYA63I2D: score=5 
    EXO1Q9UQ843I2D: score=5 
    MOCS3O953963I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS9722942
    GO:0006508proteolysis IBA--

    Find genes that share ontologies with CAPN15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAPN15 (CAN15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAPN15 gene: 
    NM_005632.2  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562370 ENST00000567216(uc002chg.3) ENST00000568988 ENST00000219611(uc002chh.1 uc002chi.3)
    ENST00000568402 ENST00000565010(uc002chj.3) ENST00000566977
    miRNA
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    Block miRNA regulation of human, mouse, rat CAPN15 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidCAPN15 3' UTR sequence
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    OriGene RNAi products in human, mouse, rat for CAPN15
    Predesigned siRNA for gene silencing in human, mouse, rat CAPN15
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    OriGene clones in human, mouse for CAPN15 (see all 7)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CAPN15
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CAPN15
      QuantiTect SYBR Green Assays in human, mouse, rat CAPN15
      QuantiFast Probe-based Assays in human, mouse, rat CAPN15

    Selected AceView cDNA sequences (see all 221):

    BM915478 BM556221 CD620956 AW249364 AA586809 BM909054 BM853547 BU192311 
    AW590760 U85647 CA488879 BM563805 BM927633 AI655982 AW613273 BX109094 
    BC001869 AW248946 NM_005632 BM827102 BM557749 BQ437907 BM053134 BC021854 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAPN15 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d
    SP1:                                                                                                                                                      
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                -                     


    ECgene alternative splicing isoforms for CAPN15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAPN15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CAPN15 Expression
    About this image

    CAPN15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPN15 Protein Expression

    UniProtKB/Swiss-Prot: CAN15_HUMAN, O75808
    Tissue specificity: Widely expressed with higher expression in brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CAPN15 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Solh5
    Capn151
    small optic lobes homolog (Drosophila)5
    calpain 151
    83.3(n)1
    89.07(a)1
      17 (13.04 cM)5
    508171  NM_015830.11  NP_056645.11 
     259595565 
    chicken
    (Gallus gallus)
    Aves SOLH1 small optic lobes homolog (Drosophila) 77.73(n)
    78.57(a)
      416389  XM_004945426.1  XP_004945483.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAPN156
    calpain 15
    70(a)
    1 ↔ 1
    GL343803.1(64722-142160)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia capn151 calpain 15 69.19(n)
    73.68(a)
      100127702  NM_001113040.1  NP_001106511.1 
    zebrafish
    (Danio rerio)
    Actinopterygii solh1 small optic lobes homolog (Drosophila) 68.62(n)
    71.79(a)
      100330198  XM_005174197.1  XP_005174254.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sol6
    small optic lobes
    27(a)
    1 ↔ 1
    X(21221357-21228939)
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T11A5.61 CELE_T11A5.6 44.75(n)
    38.89(a)
      266916  NM_001269221.1  NP_001256150.1 


    ENSEMBL Gene Tree for CAPN15 (if available)
    TreeFam Gene Tree for CAPN15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAPN15 gene
    CAPN72  

    Find genes that share paralogs with CAPN15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAPN15 (see all 554)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493271231,2
    --575860(+) AGGCCC/TTCTTC 1 -- us2k10--------
    rs1434419891,2
    --576007(+) CCCTCA/GGCATC 1 -- us2k10--------
    rs1379598721,2
    --576057(+) AGGTTA/TTAAGG 1 -- us2k10--------
    rs1435004241,2
    --576098(+) GGGAGC/TCACCT 1 -- us2k10--------
    rs1471757501,2
    --576186(+) TGGTTC/TGAAAG 1 -- us2k10--------
    rs1864011841,2
    --576320(+) CCCCAA/CTGGCC 1 -- us2k10--------
    rs1159558171,2
    C,F--579654(+) GGTCCA/GGCCCT 1 -- int11Minor allele frequency- G:0.06WA 118
    rs1809932891,2
    --579666(+) TGGCCC/TGCGGT 1 -- int10--------
    rs1848149251,2
    --579835(+) CTGGAC/TCGTGA 1 -- int10--------
    rs118646551,2
    C,F,A,H--579900(+) ACAGAA/GGAAGG 1 -- int1 trp323Minor allele frequency- G:0.35NS EA NA WA CSA 2349

    HapMap Linkage Disequilibrium report for CAPN15 (577717 - 604636 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CAPN15: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAPN15
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPN15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603267    OMIM disorders: --


    Find genes that share disorders with CAPN15           About GenesLikeMe


    Export disorders for CAPN15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAPN15 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CAPN15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia). (PubMed id 9722942)1, 2, 3 Kamei M.... Campbell H.D. (Genomics 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PubMed id 23263863)1 Li J....Sleiman P.M. (Hum. Mol. Genet. 2013)
    6. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6650 HGNC: 11182 AceView: SOLH Ensembl:ENSG00000103326 euGenes: HUgn6650
    ECgene: CAPN15 H-InvDB: CAPN15

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAPN15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAPN15 gene:
    Search GeneIP for patents involving CAPN15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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