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Aliases for CAPN15 Gene

Aliases for CAPN15 Gene

  • Calpain 15 2 3
  • SOLH 3 4 6
  • Small Optic Lobes Homolog 3 4
  • Small Optic Lobes (Drosophila) Homolog 2
  • Small Optic Lobes Homolog (Drosophila) 2
  • EC 3.4.22.54 63
  • EC 3.4.22.- 4
  • Calpain-15 3
  • EC 3.4.22 63

External Ids for CAPN15 Gene

Previous HGNC Symbols for CAPN15 Gene

  • SOLH

Previous GeneCards Identifiers for CAPN15 Gene

  • GC16P000578

Summaries for CAPN15 Gene

Entrez Gene Summary for CAPN15 Gene

  • This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPN15 Gene

CAPN15 (Calpain 15) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and peptidase activity. An important paralog of this gene is CAPN7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN15 Gene

Genomics for CAPN15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAPN15 Gene

Start:
523,982 bp from pter
End:
554,636 bp from pter
Size:
30,655 bases
Orientation:
Plus strand

Genomic View for CAPN15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN15 Gene

No data available for Regulatory Elements for CAPN15 Gene

Proteins for CAPN15 Gene

  • Protein details for CAPN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75808-CAN15_HUMAN
    Recommended name:
    Calpain-15
    Protein Accession:
    O75808
    Secondary Accessions:
    • B1B1M4
    • Q2KHS2
    • Q8WTY9
    • Q9BUW0

    Protein attributes for CAPN15 Gene

    Size:
    1086 amino acids
    Molecular mass:
    117314 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAPN15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPN15 Gene

Proteomics data for CAPN15 Gene at MOPED

Selected DME Specific Peptides for CAPN15 Gene

Post-translational modifications for CAPN15 Gene

  • Ubiquitination at Lys32, Lys348, Lys686, Lys791, Lys1053, and Lys1066
  • Modification sites at PhosphoSitePlus

Other Protein References for CAPN15 Gene

Domains for CAPN15 Gene

Protein Domains for CAPN15 Gene

Graphical View of Domain Structure for InterPro Entry

O75808

UniProtKB/Swiss-Prot:

CAN15_HUMAN :
  • O75808
Domain:
  • Contains 1 calpain catalytic domain.
Family:
  • Belongs to the peptidase C2 family.
Similarity:
  • Contains 5 RanBP2-type zinc fingers.
genes like me logo Genes that share domains with CAPN15: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CAPN15 Gene

Function for CAPN15 Gene

Enzyme Numbers (IUBMB) for CAPN15 Gene

Gene Ontology (GO) - Molecular Function for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9722942
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0008233 peptidase activity TAS 9722942
GO:0008234 cysteine-type peptidase activity TAS 9722942
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CAPN15: view

Phenotypes for CAPN15 Gene

genes like me logo Genes that share phenotypes with CAPN15: view

Animal Model Products

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAPN15 Gene

Localization for CAPN15 Gene

Gene Ontology (GO) - Cellular Components for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CAPN15 Gene

Pathways for CAPN15 Gene

SuperPathways for CAPN15 Gene

No Data Available

Interacting Proteins for CAPN15 Gene

Gene Ontology (GO) - Biological Process for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 9722942
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with CAPN15: view

No data available for Pathways by source for CAPN15 Gene

Transcripts for CAPN15 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPN15

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: -

Relevant External Links for CAPN15 Gene

GeneLoc Exon Structure for
CAPN15
ECgene alternative splicing isoforms for
CAPN15

Expression for CAPN15 Gene

mRNA expression in normal human tissues for CAPN15 Gene

Protein differential expression in normal tissues for CAPN15 Gene

This gene is overexpressed in Plasma (56.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPN15 Gene

mRNA Expression by UniProt/SwissProt for CAPN15 Gene

O75808-CAN15_HUMAN
Tissue specificity: Widely expressed with higher expression in brain.
genes like me logo Genes that share expressions with CAPN15: view

Expression partners for CAPN15 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CAPN15 Gene

Orthologs for CAPN15 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAPN15 35
  • 86.32 (n)
  • 88.25 (a)
SOLH 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN15 35
  • 87.55 (n)
  • 87.96 (a)
CAPN15 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capn15 35
  • 83.3 (n)
  • 89.07 (a)
Solh 16
Capn15 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOLH 35
  • 98.36 (n)
  • 97.65 (a)
rat
(Rattus norvegicus)
Mammalia Capn15 35
  • 83.2 (n)
  • 88.53 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPN15 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPN15 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOLH 35
  • 77.73 (n)
  • 78.57 (a)
CAPN15 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPN15 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn15 35
  • 69.19 (n)
  • 73.68 (a)
zebrafish
(Danio rerio)
Actinopterygii solh 35
  • 68.62 (n)
  • 71.79 (a)
CAPN15 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sol 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T11A5.6 35
  • 44.75 (n)
  • 38.89 (a)
F44F1.3 36
  • 21 (a)
OneToMany
F47F6.9 36
  • 24 (a)
OneToMany
H25P06.4 36
  • 21 (a)
OneToMany
T11A5.6 36
  • 32 (a)
OneToMany
W04A4.4 36
  • 24 (a)
OneToMany
W05G11.4 36
  • 31 (a)
OneToMany
Y53H1B.6 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3566 36
  • 43 (a)
OneToOne
Species with no ortholog for CAPN15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN15 Gene

ENSEMBL:
Gene Tree for CAPN15 (if available)
TreeFam:
Gene Tree for CAPN15 (if available)

Paralogs for CAPN15 Gene

Paralogs for CAPN15 Gene

genes like me logo Genes that share paralogs with CAPN15: view

Variants for CAPN15 Gene

Sequence variations from dbSNP and Humsavar for CAPN15 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs7763 -- 554,554(+) GTCAG(C/T)CCCGT utr-variant-3-prime
rs15312 -- 554,444(+) CTGGA(A/G)AAACA utr-variant-3-prime
rs733972 -- 546,762(+) GGTGG(A/G)GTCCA intron-variant, missense, reference
rs743966 -- 546,073(+) TCGCC(A/G)GGCCC intron-variant, utr-variant-5-prime
rs743967 -- 546,442(+) CACCT(C/G)TTCTT intron-variant, utr-variant-5-prime

Relevant External Links for CAPN15 Gene

HapMap Linkage Disequilibrium report
CAPN15
Human Gene Mutation Database (HGMD)
CAPN15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CAPN15 Gene

Disorders for CAPN15 Gene

No disorders were found for CAPN15 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CAPN15 Gene

Publications for CAPN15 Gene

  1. SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia). (PMID: 9722942) Kamei M. … Campbell H.D. (Genomics 1998) 2 3 4
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for CAPN15 Gene

Sources for CAPN15 Gene

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