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Aliases for CAPN14 Gene

Aliases for CAPN14 Gene

  • Calpain 14 2 3 5
  • Calcium-Activated Neutral Proteinase 14 4
  • EC 3.4.22.- 4
  • CANP 14 4

External Ids for CAPN14 Gene

Previous GeneCards Identifiers for CAPN14 Gene

  • GC02U990305
  • GC02M031370
  • GC02M031249

Summaries for CAPN14 Gene

Entrez Gene Summary for CAPN14 Gene

  • Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family.[supplied by OMIM, Mar 2008]

GeneCards Summary for CAPN14 Gene

CAPN14 (Calpain 14) is a Protein Coding gene. Among its related pathways are Apoptosis Pathway and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN14 Gene

  • Calcium-regulated non-lysosomal thiol-protease.

Tocris Summary for CAPN14 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN14 Gene

Genomics for CAPN14 Gene

Regulatory Elements for CAPN14 Gene

Enhancers for CAPN14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAPN14 on UCSC Golden Path with GeneCards custom track

Promoters for CAPN14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAPN14 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPN14 Gene

31,173,056 bp from pter
31,233,971 bp from pter
60,916 bases
Minus strand

Genomic View for CAPN14 Gene

Genes around CAPN14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN14 Gene

Proteins for CAPN14 Gene

  • Protein details for CAPN14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KRU9

    Protein attributes for CAPN14 Gene

    684 amino acids
    Molecular mass:
    79568 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAPN14 Gene


neXtProt entry for CAPN14 Gene

Proteomics data for CAPN14 Gene at MOPED

Post-translational modifications for CAPN14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAPN14 Gene

Domains & Families for CAPN14 Gene

Gene Families for CAPN14 Gene

Suggested Antigen Peptide Sequences for CAPN14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
  • Contains 1 calpain catalytic domain.
  • Contains 3 EF-hand domains.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN14: view

Function for CAPN14 Gene

Molecular function for CAPN14 Gene

UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease.

Enzyme Numbers (IUBMB) for CAPN14 Gene

Gene Ontology (GO) - Molecular Function for CAPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
genes like me logo Genes that share ontologies with CAPN14: view

Animal Model Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAPN14 Gene

Localization for CAPN14 Gene

Subcellular locations from

Jensen Localization Image for CAPN14 Gene COMPARTMENTS Subcellular localization image for CAPN14 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CAPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CAPN14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPN14 Gene

Pathways & Interactions for CAPN14 Gene

genes like me logo Genes that share pathways with CAPN14: view

Pathways by source for CAPN14 Gene

1 Tocris pathway for CAPN14 Gene

Interacting Proteins for CAPN14 Gene

Gene Ontology (GO) - Biological Process for CAPN14 Gene


No data available for SIGNOR curated interactions for CAPN14 Gene

Drugs & Compounds for CAPN14 Gene

(2) Drugs for CAPN14 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(4) Additional Compounds for CAPN14 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Acetyl-Calpastatin (184-210) (human)
MG 132
PD 150606

(5) Tocris Compounds for CAPN14 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
PD 150606 Cell permeable calpain inhibitor 179528-45-1
genes like me logo Genes that share compounds with CAPN14: view

Transcripts for CAPN14 Gene

mRNA/cDNA for CAPN14 Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAPN14 Gene

Calpain 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN14 Gene

No ASD Table

Relevant External Links for CAPN14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPN14 Gene

mRNA expression in normal human tissues for CAPN14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPN14 Gene

This gene is overexpressed in Esophagus - Mucosa (x47.8).

Protein differential expression in normal tissues from HIPED for CAPN14 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAPN14 Gene

SOURCE GeneReport for Unigene cluster for CAPN14 Gene Hs.468059

mRNA Expression by UniProt/SwissProt for CAPN14 Gene

Tissue specificity: Not expressed in tissues tested.
genes like me logo Genes that share expression patterns with CAPN14: view

Protein tissue co-expression partners for CAPN14 Gene

Primer Products

Orthologs for CAPN14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAPN14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAPN14 35
  • 85.38 (n)
  • 79.7 (a)
CAPN14 36
  • 79 (a)
(Canis familiaris)
Mammalia CAPN14 35
  • 84.84 (n)
  • 79.97 (a)
CAPN14 36
  • 75 (a)
(Pan troglodytes)
Mammalia CAPN14 35
  • 99.42 (n)
  • 98.83 (a)
CAPN14 36
  • 99 (a)
(Monodelphis domestica)
Mammalia CAPN14 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia CAPN14 36
  • 53 (a)
(Gallus gallus)
Aves CAPN14 35
  • 66.92 (n)
  • 63.22 (a)
CAPN14 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
-- 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia capn14 35
  • 61.08 (n)
  • 52.05 (a)
(Danio rerio)
Actinopterygii si:ch211-202f3.3 36
  • 33 (a)
si:ch211-202f3.4 36
  • 38 (a)
zgc:136872 36
  • 37 (a)
zgc:162184 36
  • 38 (a)
Species with no ortholog for CAPN14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPN14 Gene

Gene Tree for CAPN14 (if available)
Gene Tree for CAPN14 (if available)

Paralogs for CAPN14 Gene

Paralogs for CAPN14 Gene

(9) SIMAP similar genes for CAPN14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAPN14: view

Variants for CAPN14 Gene

Sequence variations from dbSNP and Humsavar for CAPN14 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs587885 -- 31,231,192(+) AGCTT(A/C/G/T)GATAT intron-variant
rs591606 -- 31,229,581(+) tgagg(C/G)aggct intron-variant, upstream-variant-2KB
rs594092 -- 31,231,388(+) ATTTA(C/T)TTAGA intron-variant
rs600980 -- 31,231,799(+) CAGAC(A/G)CCACT intron-variant
rs601255 -- 31,229,365(-) CATAA(C/T)TGTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAPN14 Gene

Variant ID Type Subtype PubMed ID
dgv4074n71 CNV Gain 21882294
dgv4075n71 CNV Gain 21882294
nsv873776 CNV Gain 21882294
esv24497 CNV Loss 19812545
nsv523787 CNV Loss 19592680
esv1010164 CNV Gain 20482838

Variation tolerance for CAPN14 Gene

Gene Damage Index Score: 16.45; 97.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CAPN14 Gene

Disorders for CAPN14 Gene

Relevant External Links for CAPN14

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CAPN14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN14 Gene

Publications for CAPN14 Gene

  1. Identification and characterization of two novel calpain large subunit genes. (PMID: 11675017) Dear T.N. … Boehm T. (Gene 2001) 2 3 4 67
  2. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. (PMID: 25017104) Kottyan L.C. … Rothenberg M.E. (Nat. Genet. 2014) 3
  3. GWAS identifies four novel eosinophilic esophagitis loci. (PMID: 25407941) Sleiman P.M. … Hakonarson H. (Nat Commun 2014) 3
  4. HIV gp120 induced gene expression signatures in vaginal epithelial cells. (PMID: 23867815) Fanibunda S.E. … Bandivdekar A.H. (Microbes Infect. 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for CAPN14 Gene

Sources for CAPN14 Gene