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CAPN14 Gene

protein-coding   GIFtS: 45
GCID: GC02M031370

Calpain 14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calpain 141 2
Calcium-Activated Neutral Proteinase 142 3
CANP 142 3
calpain-142
EC 3.4.22.-3

External Ids:    HGNC: 166641   Entrez Gene: 4408542   Ensembl: ENSG000002147117   OMIM: 6102295   UniProtKB: A8MX763   

Export aliases for CAPN14 gene to outside databases

Previous GC identifers: GC02U990305 GC02M031249 GC02M031133


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAPN14 Gene:
Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular
processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic
plasticity (Dear et al., 2000 (PubMed 10964513)). CAPN14 belongs to the calpain large subunit family.(supplied by
OMIM, Mar 2008)

GeneCards Summary for CAPN14 Gene:
CAPN14 (calpain 14) is a protein-coding gene. Diseases associated with CAPN14 include muscular dystrophy, and limb-girdle muscular dystrophy. GO annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is CAPN6.

UniProtKB/Swiss-Prot: CAN14_HUMAN, A8MX76
Function: Calcium-regulated non-lysosomal thiol-protease (By similarity)

summary for CAPN14 Gene:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAPN14 gene promoter:
         ISGF-3   AML1a   SRF (504 AA)   Lmo2   STAT3   AP-4   RelA   NF-kappaB   NF-kappaB1   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CAPN14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPN14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.1-p21   Ensembl cytogenetic band:  2p23.1   HGNC cytogenetic band: 2p23.1-p21

CAPN14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN14 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M031370:  view genomic region     (about GC identifiers)

Start:
31,395,922 bp from pter      End:
31,456,724 bp from pter
Size:
60,803 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAN14_HUMAN, A8MX76 (See protein sequence)
Recommended Name: Calpain-14  
Size: 684 amino acids; 79568 Da
Secondary accessions: B3KRU9
Alternative splicing: 2 isoforms:  A8MX76-1   A8MX76-2   

Explore the universe of human proteins at neXtProt for CAPN14: NX_A8MX76

Explore proteomics data for CAPN14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CAPN14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138594.1  
    ENSEMBL proteins: 
     ENSP00000381805   ENSP00000385247   ENSP00000398670  

    CAPN14 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CAPN14
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    Novus Biologicals CAPN14 Lysate
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    Cloud-Clone Corp. Proteins for CAPN14

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    CAPN14 Assay Products:

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    Cloud-Clone Corp. ELISAs for CAPN14
    Cloud-Clone Corp. CLIAs for CAPN14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 8):
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR001300 Peptidase_C2_calpain_cat
     IPR018247 EF_Hand_1_Ca_BS
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry A8MX76

    ProtoNet protein and cluster: A8MX76

    UniProtKB/Swiss-Prot: CAN14_HUMAN, A8MX76
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 3 EF-hand domains


    CAPN14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAN14_HUMAN, A8MX76
    Function: Calcium-regulated non-lysosomal thiol-protease (By similarity)

         Enzyme Number (IUBMB): EC 3.4.22.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IBA--
    GO:0005509calcium ion binding IEA--
         
    CAPN14 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPN14
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    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate CAPN14:
    hsa-miR-579 hsa-miR-203 hsa-miR-146a hsa-miR-450b-5p hsa-miR-507 hsa-miR-29b-1* hsa-miR-146b-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CAPN14
    Predesigned siRNA for gene silencing in human, mouse, rat CAPN14

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CAPN14

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    CAPN14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAPN14 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis Pathway
    Apoptosis Pathway0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Tocris Bioscience Pathway for CAPN14
        Apoptosis Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAPN14
    Interactions:

        Search GeneGlobe Interaction Network for CAPN14

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CAPN14 (ENSP000003852474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMA3ENSP000002164554STRING: ENSP00000216455
    CHMP4AENSP000003242054STRING: ENSP00000324205
    CHMP4BENSP000002174024STRING: ENSP00000217402
    CHMP4CENSP000002972654STRING: ENSP00000297265
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IBA--

    CAPN14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CAPN14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    PD 150606Cell permeable calpain inhibitor[179528-45-1]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPN14    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAPN14 gene: 
    NM_001145122.1  

    Unigene Cluster for CAPN14:

    Calpain 14
    Hs.468059  [show with all ESTs]
    Unigene Representative Sequence: NM_001145122
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398824(uc002rnt.2) ENST00000403897 ENST00000444918(uc010yms.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CAPN14 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CAPN14:
    hsa-miR-579 hsa-miR-203 hsa-miR-146a hsa-miR-450b-5p hsa-miR-507 hsa-miR-29b-1* hsa-miR-146b-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CAPN14
    Predesigned siRNA for gene silencing in human, mouse, rat CAPN14
    Clone
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    OriGene clones in human, mouse for CAPN14 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAPN14 (NM_001145122)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN14
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CAPN14
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CAPN14
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CAPN14
      QuantiTect SYBR Green Assays in human, mouse, rat CAPN14
      QuantiFast Probe-based Assays in human, mouse, rat CAPN14

    Additional mRNA sequence: 

    AK092257.1 AK296910.1 

    1 DOTS entry:

    DT.202850 

    7 AceView cDNA sequences:

    AA743820 BX091474 AA760673 BX476834 AX747435 AK092257 AA883200 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAPN14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTACAGC
    CAPN14 Expression
    About this image


    CAPN14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
    CAPN14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPN14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.468059

    UniProtKB/Swiss-Prot: CAN14_HUMAN, A8MX76
    Tissue specificity: Not expressed in tissues tested

        Custom PCR Arrays for CAPN14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CAPN14 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CAPN141 calpain 14 84.84(n)
    79.97(a)
      483026  XM_540141.3  XP_540141.3 
    chicken
    (Gallus gallus)
    Aves CAPN141 calpain 14 66.92(n)
    63.22(a)
      768684  XM_001231757.3  XP_001231758.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    68(a)
    50(a)
    1 ↔ many
    1 ↔ many
    AAWZ02041556(305-4020)
    1(250521989-250576827)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia capn141 calpain 14 61.08(n)
    52.05(a)
      101732339  XM_004914925.1  XP_004914982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-202f3.46
    zgc:1621846
    (see all 4)
    zgc:162184
    (see all 4)
    38(a)
    38(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    17(45770156-45788817) ENSDARG00000091723
    17(45816352-45846739) ENSDARG00000077217


    ENSEMBL Gene Tree for CAPN14 (if available)
    TreeFam Gene Tree for CAPN14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAPN14 gene
    CAPN62  CAPN82  CAPNS12  CAPN132  CAPN12  CAPN52  CAPN92  CAPN32  
    CAPNS22  CAPN22  CAPN122  CAPN112  CAPN102  
    9 SIMAP similar genes for CAPN14 using alignment to 3 protein entries:     CAN14_HUMAN (see all proteins):
    CAPN2    CAPN8    CAPN1    CAPN11    CAPN9    CAPN3
    CAPN13    CAPN12    CAPN5

    CAPN14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAPN14 (see all 1306)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13484371,2
    C,F,O,A,H--31396656(-) AAGAAT/CACAGG 1 -- ut3114Minor allele frequency- C:0.32NA NS EA WA CSA 919
    rs170108261,2
    C,F,H--31396729(+) CACCCA/GCTGAT 1 -- ut3125Minor allele frequency- G:0.14NA NS EA WA CSA 2783
    rs1893037621,2
    C--31396799(+) TCTGGA/CCAGAT 1 -- ut310--------
    rs1415729421,2
    --31396800(+) CTGGAC/TAGATT 1 -- ut310--------
    rs14437081,2
    C,F,O,A,H--31396801(-) AAATCT/CGTCCA 1 -- ut3115Minor allele frequency- C:0.37NS EA NA WA CSA 918
    rs170108321,2
    C,F,H--31396812(+) GAAATG/AGATCT 1 -- ut3120Minor allele frequency- A:0.07NA NS EA WA CSA 2262
    rs1818938971,2
    --31396909(+) CCCCAG/TATCCA 1 -- ut310--------
    rs9616421,2
    C,F,O,A,H--31396921(-) TCTCCG/ATATGA 1 -- ut3115Minor allele frequency- A:0.35NS EA NA WA CSA 927
    rs1509115401,2
    C--31396954(+) CATGAC/TCTCAG 1 -- ut310--------
    rs1378739701,2
    --31396959(+) CCTCAC/GATGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CAPN14 (31395922 - 31456724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CAPN14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523787CNV Loss19592680
    esv24497CNV Loss19812545
    esv1010164CNV Gain20482838
    dgv4074n71CNV Gain21882294
    dgv4075n71CNV Gain21882294
    nsv873776CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAPN14
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPN14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610229    OMIM disorders: --

    4 diseases for CAPN14:    
    About MalaCards
    muscular dystrophy    limb-girdle muscular dystrophy    alzheimer's disease    bronchiolitis


    CAPN14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAPN14

    Export disorders for CAPN14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAPN14 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CAPN14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of two novel calpain large subunit genes. (PubMed id 11675017)1, 2, 3 Dear T.N. and Boehm T. (Gene 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene family. (PubMed id 10964513)1 Dear T.N....Boehm T. (Genomics 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 440854 HGNC: 16664 AceView: LOC440854 Ensembl:ENSG00000214711 euGenes: HUgn440854
    ECgene: CAPN14 H-InvDB: CAPN14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAPN14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAPN14 gene:
    Search GeneIP for patents involving CAPN14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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