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Aliases for CAPN13 Gene

Aliases for CAPN13 Gene

  • Calpain 13 2 3
  • Calcium-Activated Neutral Proteinase 13 3 4
  • CANP 13 3 4
  • EC 3.4.22.- 4
  • Calpain-13 3

External Ids for CAPN13 Gene

Previous GeneCards Identifiers for CAPN13 Gene

  • GC02M030860
  • GC02M031061
  • GC02M030938
  • GC00U916966
  • GC02M030857
  • GC02M030799
  • GC02M030945

Summaries for CAPN13 Gene

Entrez Gene Summary for CAPN13 Gene

  • The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]

GeneCards Summary for CAPN13 Gene

CAPN13 (Calpain 13) is a Protein Coding gene. Among its related pathways are Apoptosis Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN13 Gene

  • Probable non-lysosomal thiol-protease.

Tocris Summary for CAPN13 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN13 Gene

Genomics for CAPN13 Gene

Regulatory Elements for CAPN13 Gene

Genomic Location for CAPN13 Gene

Start:
30,722,771 bp from pter
End:
30,820,542 bp from pter
Size:
97,772 bases
Orientation:
Minus strand

Genomic View for CAPN13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPN13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN13 Gene

Proteins for CAPN13 Gene

  • Protein details for CAPN13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6MZZ7-CAN13_HUMAN
    Recommended name:
    Calpain-13
    Protein Accession:
    Q6MZZ7
    Secondary Accessions:
    • Q17RF0
    • Q580X1
    • Q8TE80

    Protein attributes for CAPN13 Gene

    Size:
    669 amino acids
    Molecular mass:
    76696 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAPN13 Gene

    Alternative splice isoforms for CAPN13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPN13 Gene

Proteomics data for CAPN13 Gene at MOPED

Post-translational modifications for CAPN13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN13 Gene

No data available for DME Specific Peptides for CAPN13 Gene

Domains for CAPN13 Gene

Suggested Antigen Peptide Sequences for CAPN13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6MZZ7

UniProtKB/Swiss-Prot:

CAN13_HUMAN :
  • Q6MZZ7
Domain:
  • Contains 1 calpain catalytic domain.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN13: view

No data available for Gene Families for CAPN13 Gene

Function for CAPN13 Gene

Molecular function for CAPN13 Gene

UniProtKB/Swiss-Prot Function: Probable non-lysosomal thiol-protease.

Enzyme Numbers (IUBMB) for CAPN13 Gene

Gene Ontology (GO) - Molecular Function for CAPN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CAPN13: view

Animal Model Products

CRISPR Products

miRNA for CAPN13 Gene

miRTarBase miRNAs that target CAPN13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPN13

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAPN13 Gene

Localization for CAPN13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN13 Gene COMPARTMENTS Subcellular localization image for CAPN13 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CAPN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPN13 Gene

Pathways for CAPN13 Gene

SuperPathways for CAPN13 Gene

Superpath Contained pathways
1 Apoptosis Pathway
genes like me logo Genes that share pathways with CAPN13: view

Pathways by source for CAPN13 Gene

1 Tocris pathway for CAPN13 Gene

Interacting Proteins for CAPN13 Gene

Gene Ontology (GO) - Biological Process for CAPN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with CAPN13: view

Compounds for CAPN13 Gene

(4) Tocris Compounds for CAPN13 Gene

Compound Action Cas Number
MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
MG 101 Calpain inhibitor; activates p53-dependent apoptosis [110044-82-1]
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation [133407-82-6]
PD 150606 Cell permeable calpain inhibitor [179528-45-1]

(1) HMDB Compounds for CAPN13 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CAPN13: view

Transcripts for CAPN13 Gene

Unigene Clusters for CAPN13 Gene

Calpain 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPN13

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CAPN13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
SP1:
SP2:
SP3: -
SP4: -
SP5: - - -
SP6:

ExUns: 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CAPN13 Gene

GeneLoc Exon Structure for
CAPN13
ECgene alternative splicing isoforms for
CAPN13

Expression for CAPN13 Gene

mRNA expression in normal human tissues for CAPN13 Gene

mRNA differential expression in normal tissues according to GTEx for CAPN13 Gene

This gene is overexpressed in Stomach (13.2), Small Intestine - Terminal Ileum (10.5), Colon - Transverse (5.3), and Cervix - Endocervix (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAPN13 Gene

SOURCE GeneReport for Unigene cluster for CAPN13 Gene Hs.660911

mRNA Expression by UniProt/SwissProt for CAPN13 Gene

Q6MZZ7-CAN13_HUMAN
Tissue specificity: Weakly expressed in lung and testis. Weakly or not expressed in other tissues.
genes like me logo Genes that share expressions with CAPN13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CAPN13 Gene

Orthologs for CAPN13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAPN13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPN13 35
  • 96.75 (n)
  • 95.69 (a)
CAPN13 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPN13 35
  • 73.99 (n)
  • 61.09 (a)
CAPN13 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN13 35
  • 76.26 (n)
  • 63.86 (a)
CAPN13 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capn13 35
  • 75.85 (n)
  • 67.73 (a)
Capn13 16
Capn13 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPN13 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPN13 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capn13 35
  • 75.34 (n)
  • 67.37 (a)
chicken
(Gallus gallus)
Aves CAPN13 35
  • 55.22 (n)
  • 43.71 (a)
CAPN13 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPN13 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn13 35
  • 53.3 (n)
  • 42.03 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-202f3.3 36
  • 33 (a)
ManyToMany
si:ch211-202f3.4 36
  • 33 (a)
ManyToMany
zgc:136872 36
  • 34 (a)
ManyToMany
zgc:162184 36
  • 32 (a)
ManyToMany
Species with no ortholog for CAPN13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPN13 Gene

ENSEMBL:
Gene Tree for CAPN13 (if available)
TreeFam:
Gene Tree for CAPN13 (if available)

Paralogs for CAPN13 Gene

Selected SIMAP similar genes for CAPN13 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPN13: view

Variants for CAPN13 Gene

Sequence variations from dbSNP and Humsavar for CAPN13 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs471381 -- 30,740,335(-) CAGGT(A/G)GATCG intron-variant
rs476216 -- 30,729,624(+) AAATA(C/T)GATTG intron-variant
rs477229 -- 30,735,271(+) TGGAT(G/T)AGGTG intron-variant
rs479103 -- 30,746,602(-) AATCT(A/G)TCCAC intron-variant
rs482384 -- 30,754,488(-) GGTAG(A/G)ATGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN13 Gene

Variant ID Type Subtype PubMed ID
nsv873770 CNV Loss 21882294
nsv520269 CNV Gain 19592680
nsv456019 CNV Loss 19166990
esv9096 CNV Gain 19470904
nsv833659 CNV Gain 17160897
esv275432 CNV Loss 21479260

Relevant External Links for CAPN13 Gene

HapMap Linkage Disequilibrium report
CAPN13
Human Gene Mutation Database (HGMD)
CAPN13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN13 Gene

Disorders for CAPN13 Gene

Relevant External Links for CAPN13

Genetic Association Database (GAD)
CAPN13
Human Genome Epidemiology (HuGE) Navigator
CAPN13
genes like me logo Genes that share disorders with CAPN13: view

No data available for UniProtKB/Swiss-Prot for CAPN13 Gene

Publications for CAPN13 Gene

  1. Identification and characterization of two novel calpain large subunit genes. (PMID: 11675017) Dear T.N. … Boehm T. (Gene 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CAPN13 Gene

Sources for CAPN13 Gene

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