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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CAPN12 Gene

protein-coding GIFtS: 51
GCID: GC19M039220

calpain 12

Explore 4 diseases affiliated with
CAPN12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calpain 12¹ ²		EC 3.4.22.-³
Calcium-Activated Neutral Proteinase 12² ³		EC 3.4.22⁸
CANP 12² ³		EC 3.4.22.52⁸
Calpain-12¹		EC 3.4.22.54⁸

External Ids:	HGNC: 13249¹	Entrez Gene: 147968²	Ensembl: ENSG00000182472⁷	OMIM: 608839⁵	UniProtKB: Q6ZSI9³

Export aliases for CAPN12 gene to outside databases

Previous GC identifers: GC00U906237 GC19M043896 GC19M043912 GC19M043913 GC19M035667

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAPN12:

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian

calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of

heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene

encodes a member of the calpain large subunit family. (provided by RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: CAN12_HUMAN, Q6ZSI9

Function: Calcium-regulated non-lysosomal thiol-protease (By similarity)

summary for CAPN12:

Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.

This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most

well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa

regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated

by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization

(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,

remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,

proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling

progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic

pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been

associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's

disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CAPN12 gene promoter:
Sp1 SREBP-1c Roaz SREBP-1b Max Egr-2 S8 SREBP-1a ZIC2/Zic2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAPN12 promoter sequence

Search SABiosciences Chromatin IP Primers for CAPN12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

CAPN12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN12 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M039220: view genomic region (about GC identifiers)

Start:	39,220,832 bp from pter	End:	39,235,114 bp from pter
Size:	14,283 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAN12_HUMAN, Q6ZSI9 (See protein sequence)

Recommended Name: Calpain-12

Size: 719 amino acids; 81037 Da

Explore the universe of human proteins at neXtProt for CAPN12: NX_Q6ZSI9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZSI9

4/7 DME Specific Peptides for CAPN12 (Q6ZSI9) (see all 7)

RLRNPWG

LVKGHAY

TFWTNPQ

LLEKAYAK

CAPN12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653292.2

ENSEMBL proteins:

ENSP00000331636

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CAPN12

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

CAPN12 for ontologies About GeneDecksing

CAPN12 Antibody Products:

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	Uscn ELISAs and CLIAs for CAPN12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CAPN12 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR001300 Peptidase_C2_calpain_cat

IPR018247 EF_Hand_1_Ca_BS

IPR000169 Pept_cys_AS

Graphical View of Domain Structure for InterPro Entry Q6ZSI9

ProtoNet protein and cluster: Q6ZSI9

1 Blocks protein family: IPB001300 Calpain cysteine protease (C2) family signature

UniProtKB/Swiss-Prot: CAN12_HUMAN, Q6ZSI9

Similarity: Belongs to the peptidase C2 family

Similarity: Contains 1 calpain catalytic domain

Similarity: Contains 1 EF-hand domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CAN12_HUMAN, Q6ZSI9

Function: Calcium-regulated non-lysosomal thiol-protease (By similarity)

Catalytic activity: Broad endopeptidase specificity

Enzyme Numbers (IUBMB): EC 3.4.22.54² EC 3.4.22² EC 3.4.22.52² EC 3.4.22.-¹

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN12
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPN12 (see all 19):
		hsa-miR-330-5p hsa-miR-3653 hsa-miR-410 hsa-miR-637 hsa-miR-654-5p hsa-miR-3658 hsa-miR-326 hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: CAPN12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPN12 (see all 7) OriGene shRNA RFP: CAPN12 OriGene siRNA: CAPN12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN12

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CAPN12

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN12

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--

CAPN12 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis Pathway

Apoptosis Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Tocris Bioscience Pathway for CAPN12

Apoptosis Pathway

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CAPN12

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

CAPN12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for CAPN12:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for CAPN12 available from Tocris Bioscience About this table

Compound	Action	CAS #
Calpeptin	Calpain and cathepsin L inhibitor	[117591-20-5]
Acetyl-Calpastatin (184-210) (human)	Selective calpain inhibitor	[123714-50-1]
MDL 28170	Potent, selective calpain and cathepsin B inhibitor	[88191-84-8]
MG 132	Proteasome and calpain inhibitor. Inhibits NF-kappaB activation	[133407-82-6]
MG 101	Calpain inhibitor; activates p53-dependent apoptosis	[110044-82-1]

1 HMDB Compound for CAPN12 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about CAPN12 / CAN12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CAPN12 gene:

NM_144691.3

Unigene Cluster for CAPN12:

Calpain 12

Hs.731775 [show with all ESTs]

Unigene Representative Sequence: NM_144691

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000328867(uc010egd.1 uc002ojc.1 uc002ojd.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN12
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPN12 (see all 19):
		hsa-miR-330-5p hsa-miR-3653 hsa-miR-410 hsa-miR-637 hsa-miR-654-5p hsa-miR-3658 hsa-miR-326 hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: CAPN12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPN12 (see all 7) OriGene shRNA RFP: CAPN12 OriGene siRNA: CAPN12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN12

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN12 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN12 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CAPN12 (NM_144691)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN12

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN12

Additional cDNA sequence:

AK094707.1 AK125713.1 AK127398.1 BC014027.2 BC040022.1

14 DOTS entries:

DT.87077774 DT.454297 DT.92330587 DT.100857868 DT.100857867 DT.95249964 DT.95369503 DT.99933754

DT.121498882 DT.100809830 DT.95158943 DT.100857873 DT.70100889 DT.91745742

24/90 AceView cDNA sequences (see all 90):

AK125713 NM_144691 BF197540 BF476355 AA702768 BQ928225 AI015383 AA931336

AI921639 BC014027 BX509166 BM129280 AI799215 AA834121 AW628291 CD637164

H50993 AK094707 BM850920 CD637163 BF058339 AA938561 BC040022 AI302846

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN12 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16a	·	16b	·	16c
SP1:																							-
SP2:																																	-		-
SP3:																																	-		-
SP4:																															-		-		-		-
SP5:					-								-

ECgene alternative splicing isoforms for CAPN12

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CAPN12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTATTATC

About this image

CAPN12 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CAPN12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAPN12

SOURCE GeneReport for Unigene cluster: Hs.731775

SABiosciences Custom PCR Arrays for CAPN12

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAPN12 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Capn12^{1 , 5}	calpain 12^{1, 5}	84.19(n)¹ 86.23(a)¹		7 (16.94 cM)⁵ 60594¹ NM_001110807.1¹ NP_001104277.1¹ 28881656⁵
lizard (Anolis carolinensis)	Reptilia	CAPN12⁶	--	44(a)	1 ↔ 1	AAWZ02036781(3246-19007)
fruit fly (Drosophila melanogaster)	Insecta	CalpA⁶ CalpB⁶	Calpain-B	30(a) 27(a)	many ↔ many many ↔ many	2R(15312578-15318068) 3L(9881862-9886419)
worm (Caenorhabditis elegans)	Secernentea	clp-4⁶ clp-6⁶ (see all 5)	CaLPain family member (clp-6) (see all 5)	26(a) 25(a) (see all 5)	many ↔ many many ↔ many (see all 5)	III(1807725-1818316) IV(1429547-1435017)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATDEK1⁶	calpain-type cysteine protease	6(a)	1 → many	1(20653820-20665095)
rice (Oryza sativa)	Liliopsida	--	calpain, putative, expressed	6(a)	1 → many	2(29335385-29352022)

ENSEMBL Gene Tree for CAPN12 (if available)
TreeFam Gene Tree for CAPN12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CAPN12 gene

CAPN6² CAPN8² CAPN14² CAPN13² CAPN5² CAPN9² CAPN1² CAPN3²

CAPN2² CAPN7² SOLH² CAPN11² CAPN10²

7 SIMAP similar genes for CAPN12 using alignment to 7 protein entries: CAN12_HUMAN (see all proteins):

CAPN8 CAPN1 CAPN11 CAPN2 CAPN9 CAPN14

CAPN3

CAPN12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112720316^1,2	C,	--	35681008(+)	`GTCCCA/C/GAGCCC`	1	--	int¹		1		NA	2
rs141208726^1,2	C,	--	39221716(+)	`TCCCC-/CCAT GCCCCACCATG`	1	--	int¹		0	--	--	--	--
rs201216690^1,2		--	39221730(+)	`ACCATA/GCCGGG`	1	--	int¹		0	--	--	--	--
rs200491899^1,2		--	39221732(+)	`CATGCC/TGGGGT`	1	--	int¹		0	--	--	--	--
rs139997883^1,2	C,F,	--	39221781(+)	`GACACG/AAACCG`	2	/F	syn¹		1		NA	4490
rs139019209^1,2	C,F	--	39221785(+)	`CGAACC/TGCTCG`	2	Q R	mis¹		1		NA	4504
rs144919021^1,2	C,	--	39221815(+)	`TATCCC/TGGTAG`	2	Q R	mis¹		0	--	--	--	--
rs143345899^1,2	C,F,	--	39221822(+)	`GTAGCG/AGCTGG`	2	/R /C	mis¹		2		NA EU	5663
rs200530826^1,2	C,F	--	39221828(+)	`GCTGGT/GGAGGG`	2	/T /P	mis¹		1		EU	271
rs199742436^1,2		--	39221858(+)	`CAGGTA/GGAAGC`	2	H Y	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CAPN12 (39220832 - 39235114 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CAPN12
1 CNV: 9794
1 Inversion: 37203

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAPN12

DNA2.0 Custom Variant and Variant Library Synthesis for CAPN12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CAPN12 for disorders           About GeneDecksing

OMIM gene information: 608839    OMIM disorders: --

4 diseases for CAPN12:    About MalaCards

muscular dystrophy gastric cancer alzheimer's disease neuronitis

Export disorders for CAPN12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CAPN12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CAPN12)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene family. (PubMed id 10964513)¹ Dear T.N....Boehm T. (2000)
Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro. (PubMed id 16388011)⁹ Ashizawa K....Tsuzuki Y. (2006)
Profiling proteins related to amyloid deposited brain of Tg2576 mice. (PubMed id 15378736)⁹ Shin S.J....Mook-Jung I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 147968	HGNC: 13249	AceView: CAPN12	Ensembl:ENSG00000182472	euGenes: HUgn147968
ECgene: CAPN12	H-InvDB: CAPN12

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CAPN12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CAPN12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CAPN12 gene:
Search GeneIP for patents involving CAPN12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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CAPN12 Gene

calpain 12

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CAPN12 Gene

calpain 12

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for CAPN12 gene

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for CAPN12 gene

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for CAPN12 gene

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for CAPN12 gene

Transcripts
for CAPN12 gene

Expression
for CAPN12 gene

Orthologs
for CAPN12 gene

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for CAPN12 gene

Genomic Variants
for CAPN12 gene

Disorders / Diseases
for CAPN12 gene

Publications
for CAPN12 gene

Intellectual Property
for CAPN12 gene

Products
for CAPN12 gene