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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPN12 Gene

protein-coding   GIFtS: 51
GCID: GC19M039220

Calpain 12

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calpain 121 2     EC 3.4.22.-3
Calcium-Activated Neutral Proteinase 122 3     EC 3.4.228
CANP 122 3     EC 3.4.22.528
calpain-122     EC 3.4.22.548

External Ids:    HGNC: 132491   Entrez Gene: 1479682   Ensembl: ENSG000001824727   OMIM: 6088395   UniProtKB: Q6ZSI93   

Export aliases for CAPN12 gene to outside databases

Previous GC identifers: GC00U906237 GC19M043896 GC19M043912 GC19M043913 GC19M035667


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAPN12 Gene:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The
mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes
consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory
subunit. This gene encodes a member of the calpain large subunit family. (provided by RefSeq, Jun 2012)

GeneCards Summary for CAPN12 Gene: 
CAPN12 (calpain 12) is a protein-coding gene. Diseases associated with CAPN12 include gastric cancer, and muscular dystrophy, and among its related super-pathways are NF-kappaB Pathway. GO annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is CAPN6.

UniProtKB/Swiss-Prot: CAN12_HUMAN, Q6ZSI9
Function: Calcium-regulated non-lysosomal thiol-protease (By similarity)

summary for CAPN12 Gene:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPN12 gene promoter:
         Sp1   SREBP-1c   Roaz   SREBP-1b   Max   Egr-2   S8   SREBP-1a   ZIC2/Zic2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPN12 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPN12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CAPN12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN12 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039220:  view genomic region     (about GC identifiers)

Start:
39,220,827 bp from pter      End:
39,260,544 bp from pter
Size:
39,718 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAN12_HUMAN, Q6ZSI9 (See protein sequence)
Recommended Name: Calpain-12  
Size: 719 amino acids; 81037 Da

Explore the universe of human proteins at neXtProt for CAPN12: NX_Q6ZSI9

Explore proteomics data for CAPN12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZSI9

  • 4/7 DME Specific Peptides for CAPN12 (Q6ZSI9) (see all 7)
     RLRNPWG  LVKGHAY  TFWTNPQ  LLEKAYAK 

    CAPN12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAPN12 Protein Expression
    REFSEQ proteins: NP_653292.2  
    ENSEMBL proteins: 
     ENSP00000469217   ENSP00000470760   ENSP00000473156   ENSP00000331636   ENSP00000471007  
     ENSP00000470233   ENSP00000471510  

    Human Recombinant Protein Products for CAPN12: 
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    Novus Biologicals CAPN12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAPN12 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    CAPN12 for ontologies           About GeneDecksing



    CAPN12 Antibody Products: 
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    Assay Products for CAPN12: 
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    Cloud-Clone Corp. ELISAs for CAPN12 
    Cloud-Clone Corp. CLIAs for CAPN12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5/8 InterPro protein domains (see all 8):
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR001300 Peptidase_C2_calpain_cat
     IPR018247 EF_Hand_1_Ca_BS
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry Q6ZSI9

    ProtoNet protein and cluster: Q6ZSI9

    1 Blocks protein domain: IPB001300 Calpain cysteine protease (C2) family signature

    UniProtKB/Swiss-Prot: CAN12_HUMAN, Q6ZSI9
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 1 EF-hand domain


    CAPN12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAN12_HUMAN, Q6ZSI9
    Function: Calcium-regulated non-lysosomal thiol-protease (By similarity)
    Catalytic activity: Broad endopeptidase specificity

         Enzyme Numbers (IUBMB): EC 3.4.22.542 EC 3.4.222 EC 3.4.22.522 EC 3.4.22.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
         
    CAPN12 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAPN12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAPN12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPN12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPN12 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN12
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPN12 (see all 19):
    hsa-miR-330-5p hsa-miR-3653 hsa-miR-410 hsa-miR-637 hsa-miR-654-5p hsa-miR-3658 hsa-miR-326 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCAPN12 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAPN12 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptosis Pathway
    Apoptosis Pathway0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Tocris Bioscience Pathway for CAPN12
        Apoptosis Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAPN12

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    CAPN12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for CAPN12:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CAPN12 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    PD 150606Cell permeable calpain inhibitor[179528-45-1]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPN12    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about CAPN12 / CAN12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAPN12 gene: 
    NM_144691.3  

    Unigene Cluster for CAPN12:

    Calpain 12
    Hs.731775  [show with all ESTs]
    Unigene Representative Sequence: NM_144691
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594552 ENST00000597987 ENST00000601953 ENST00000593700 ENST00000597716
    ENST00000328867(uc010egd.1 uc002ojc.1 uc002ojd.1) ENST00000595177
    ENST00000597354 ENST00000601685 ENST00000594497 ENST00000598684 ENST00000597740


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN12
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPN12 (see all 19):
    hsa-miR-330-5p hsa-miR-3653 hsa-miR-410 hsa-miR-637 hsa-miR-654-5p hsa-miR-3658 hsa-miR-326 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCAPN12 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAPN12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN12
    Clone
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    GenScript: all cDNA clones in your preferred vector: CAPN12 (NM_144691)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN12
    Sirion Biotech Customized lentivirus for stable overexpression of CAPN12 
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    OriGene qSTAR qPCR primer pairs in human, mouse for CAPN12
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPN12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN12

    Additional mRNA sequence: 

    AK094707.1 AK125713.1 AK127398.1 BC014027.2 BC040022.1 

    12 DOTS entries:

    DT.454297  DT.87077774  DT.92330587  DT.99933754  DT.121498882  DT.95369503  DT.100809830  DT.100857867 
    DT.100857868  DT.70100889  DT.91745742  DT.95249964 

    24/90 AceView cDNA sequences (see all 90):

    AK125713 NM_144691 BC040022 BE872274 BF197540 AW292852 AW628291 CD637164 
    AI799215 BM850920 BQ928225 AA931336 AW450718 AA938561 BX509166 BF058339 
    AI015383 AI824068 AA228347 AI921639 BC014027 BG831319 BF476355 AI302846 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN12 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
    SP1:                                                                    -                                                                                 
    SP2:                                                                                                  -     -                                             
    SP3:                                                                                                  -     -                                             
    SP4:                                                                                            -     -     -     -                                       
    SP5:              -                       -                                                                                                               


    ECgene alternative splicing isoforms for CAPN12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPN12 expression in normal human tissues (normalized intensities)      CAPN12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATTATC
    CAPN12 Expression
    About this image


    CAPN12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See CAPN12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPN12

    SOURCE GeneReport for Unigene cluster: Hs.731775
        SABiosciences Custom PCR Arrays for CAPN12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CAPN12 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capn121 , 5 calpain 121, 5 84.19(n)1
    86.23(a)1
      7 (16.94 cM)5
    605941  NM_001110807.11  NP_001104277.11 
     288816565 
    lizard
    (Anolis carolinensis)
    Reptilia CAPN126
    Uncharacterized protein
    45(a)
    1 ↔ 1
    AAWZ02036781(3246-19007)
    fruit fly
    (Drosophila melanogaster)
    Insecta CalpA6
    CalpB6
    Calpain-B
    30(a)
    27(a)
    many ↔ many
    many ↔ many
    2R(15312578-15318068)
    3L(9881862-9886419)
    worm
    (Caenorhabditis elegans)
    Secernentea clp-46
    clp-16
    (see all 5)
    Calpain clp-1
    (see all 5)
    27(a)
    26(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    III(1807734-1818325)
    III(7981067-7986337)


    ENSEMBL Gene Tree for CAPN12 (if available)
    TreeFam Gene Tree for CAPN12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAPN12 gene
    CAPN62  CAPN82  CAPN142  CAPNS12  CAPN132  CAPN12  CAPN52  CAPN92  
    CAPN32  CAPNS22  CAPN22  CAPN112  CAPN102  
    8 SIMAP similar genes for CAPN12 using alignment to 7 protein entries:     CAN12_HUMAN (see all proteins):
    CAPN2    CAPN8    CAPN11    CAPN1    CAPNS1    CAPN9
    CAPN3    CAPN14

    CAPN12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/593 SNPs in CAPN12 are shown (see all 593)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412087261,2
    C--39221716(+) TCCCC-/CCAT  
      GCCCCA
    CCATG
    1 -- int10--------
    rs2012166901,2
    C--39221730(+) ACCATA/GCCGGG 1 -- int10--------
    rs2004918991,2
    --39221732(+) CATGCC/TGGGGT 1 -- int10--------
    rs1399978831,2
    C,F--39221781(+) GACACG/AAACCG 2 /F syn11Minor allele frequency- A:0.01NA 4490
    rs1390192091,2
    C,F--39221785(+) CGAACC/TGCTCG 2 Q R mis11Minor allele frequency- T:0.00NA 4504
    rs1995588211,2
    C--39221801(+) CACACA/GCAGAC 2 R C mis10--------
    rs1449190211,2
    C--39221815(+) TATCCC/TGGTAG 2 Q R mis10--------
    rs1433458991,2
    C,F--39221822(+) GTAGCG/AGCTGG 2 /R /C mis12Minor allele frequency- A:0.00NA EU 5663
    rs2005308261,2
    C,F--39221828(+) GCTGGT/GGAGGG 2 /T /P mis11Minor allele frequency- G:0.07EU 271
    rs1997424361,2
    --39221858(+) CAGGTA/GGAAGC 2 H Y mis10--------

    HapMap Linkage Disequilibrium report for CAPN12 (39220827 - 39260544 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CAPN12:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv641e199CNV Deletion23128226
    esv2661022CNV Deletion23128226
    esv2718536CNV Deletion23290073
    esv2718537CNV Deletion23290073
    nsv911668CNV Loss21882294
    nsv833828CNV Loss17160897
    nsv911669CNV Loss21882294
    nsv817834CNV Gain17921354
    nsv7307OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608839    OMIM disorders: --

    3 diseases for CAPN12:    About MalaCards
    gastric cancer    muscular dystrophy    alzheimer's disease


    CAPN12 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for CAPN12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPN12 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CAPN12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    3. Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene family. (PubMed id 10964513)1 Dear T.N....Boehm T. (2000)
    4. Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro. (PubMed id 16388011)9 Ashizawa K....Tsuzuki Y. (2006)
    5. Profiling proteins related to amyloid deposited brain of Tg2576 mice. (PubMed id 15378736)9 Shin S.J....Mook-Jung I. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147968 HGNC: 13249 AceView: CAPN12 Ensembl:ENSG00000182472 euGenes: HUgn147968
    ECgene: CAPN12 H-InvDB: CAPN12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPN12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAPN12 gene:
    Search GeneIP for patents involving CAPN12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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