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Aliases for CAPN12 Gene

Aliases for CAPN12 Gene

  • Calpain 12 2 3
  • Calcium-Activated Neutral Proteinase 12 3 4
  • CANP 12 3 4
  • EC 63
  • EC 63
  • EC 3.4.22.- 4
  • Calpain-12 3
  • EC 3.4.22 63

External Ids for CAPN12 Gene

Previous GeneCards Identifiers for CAPN12 Gene

  • GC00U906237
  • GC19M043896
  • GC19M043912
  • GC19M043913
  • GC19M039220
  • GC19M035667

Summaries for CAPN12 Gene

Entrez Gene Summary for CAPN12 Gene

  • The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]

GeneCards Summary for CAPN12 Gene

CAPN12 (Calpain 12) is a Protein Coding gene. Among its related pathways are Apoptosis Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN12 Gene

  • Calcium-regulated non-lysosomal thiol-protease.

Tocris Summary for CAPN12 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN12 Gene

Genomics for CAPN12 Gene

Regulatory Elements for CAPN12 Gene

Genomic Location for CAPN12 Gene

38,730,187 bp from pter
38,769,904 bp from pter
39,718 bases
Minus strand

Genomic View for CAPN12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN12 Gene

Proteins for CAPN12 Gene

  • Protein details for CAPN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CAPN12 Gene

    719 amino acids
    Molecular mass:
    81037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CAPN12 Gene

Proteomics data for CAPN12 Gene at MOPED

Selected DME Specific Peptides for CAPN12 Gene

Post-translational modifications for CAPN12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN12 Gene

Antibody Products

Domains for CAPN12 Gene

Gene Families for CAPN12 Gene

Suggested Antigen Peptide Sequences for CAPN12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
  • Contains 1 calpain catalytic domain.
  • Contains 1 EF-hand domain.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN12: view

Function for CAPN12 Gene

Molecular function for CAPN12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease.

Enzyme Numbers (IUBMB) for CAPN12 Gene

Gene Ontology (GO) - Molecular Function for CAPN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CAPN12: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAPN12 Gene

Localization for CAPN12 Gene

Subcellular locations from

Jensen Localization Image for CAPN12 Gene COMPARTMENTS Subcellular localization image for CAPN12 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAPN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPN12 Gene

Pathways for CAPN12 Gene

SuperPathways for CAPN12 Gene

Superpath Contained pathways
1 Apoptosis Pathway
genes like me logo Genes that share pathways with CAPN12: view

Pathways by source for CAPN12 Gene

1 Tocris pathway for CAPN12 Gene

Interacting Proteins for CAPN12 Gene

Gene Ontology (GO) - Biological Process for CAPN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with CAPN12: view

Drugs for CAPN12 Gene

(4) Tocris Compounds for CAPN12 Gene

Compound Action Cas Number
MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
MG 101 Calpain inhibitor; activates p53-dependent apoptosis [110044-82-1]
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation [133407-82-6]
PD 150606 Cell permeable calpain inhibitor [179528-45-1]

(1) HMDB Compounds for CAPN12 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CAPN12: view

Transcripts for CAPN12 Gene

Unigene Clusters for CAPN12 Gene

Calpain 12:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPN12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - -
SP7: - - -

Relevant External Links for CAPN12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPN12 Gene

mRNA expression in normal human tissues for CAPN12 Gene

mRNA differential expression in normal tissues according to GTEx for CAPN12 Gene

This gene is overexpressed in Liver (13.6), Kidney - Cortex (8.3), Skin - Not Sun Exposed (Suprapubic) (4.8), and Cervix - Endocervix (4.2).

Protein differential expression in normal tissues for CAPN12 Gene

This gene is overexpressed in Gallbladder (39.5) and Blymphocyte (29.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAPN12 Gene

SOURCE GeneReport for Unigene cluster for CAPN12 Gene Hs.731775

genes like me logo Genes that share expressions with CAPN12: view

Expression partners for CAPN12 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CAPN12 Gene

Orthologs for CAPN12 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAPN12 35
  • 86.44 (n)
  • 85.65 (a)
CAPN12 36
  • 86 (a)
(Canis familiaris)
Mammalia CAPN12 35
  • 88.78 (n)
  • 89.87 (a)
CAPN12 36
  • 73 (a)
(Mus musculus)
Mammalia Capn12 35
  • 83.87 (n)
  • 85.54 (a)
Capn12 16
Capn12 36
  • 86 (a)
(Pan troglodytes)
Mammalia CAPN12 35
  • 97.75 (n)
  • 97 (a)
CAPN12 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Capn12 35
  • 82.61 (n)
  • 84.14 (a)
(Monodelphis domestica)
Mammalia CAPN12 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CAPN12 36
  • 73 (a)
(Anolis carolinensis)
Reptilia CAPN12 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495980 35
  • 53.63 (n)
  • 47.35 (a)
(Danio rerio)
Actinopterygii capn12 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CalpA 36
  • 31 (a)
CalpB 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea clp-1 36
  • 26 (a)
clp-3 36
  • 25 (a)
clp-4 36
  • 27 (a)
clp-6 36
  • 31 (a)
clp-7 36
  • 26 (a)
Species with no ortholog for CAPN12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN12 Gene

Gene Tree for CAPN12 (if available)
Gene Tree for CAPN12 (if available)

Paralogs for CAPN12 Gene

(8) SIMAP similar genes for CAPN12 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CAPN12: view

Variants for CAPN12 Gene

Sequence variations from dbSNP and Humsavar for CAPN12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1106372 -- 38,742,581(-) GCCAC(C/T)GCACC intron-variant
rs2001856 -- 38,742,108(+) ATCAC(A/G)AGGTC intron-variant
rs4261660 -- 38,742,617(+) GGAGG(C/T)CAAGG intron-variant
rs4801859 -- 38,731,307(+) GGAGG(A/T)CATGA intron-variant
rs4801861 -- 38,733,773(+) TTGTT(A/G)AATAT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CAPN12 Gene

Variant ID Type Subtype PubMed ID
nsv833828 CNV Loss 17160897
nsv817834 CNV Gain 17921354
nsv911668 CNV Loss 21882294
nsv911669 CNV Loss 21882294
dgv641e199 CNV Deletion 23128226
nsv7307 OTHER Inversion 18451855
esv2718536 CNV Deletion 23290073
esv2718537 CNV Deletion 23290073
esv2661022 CNV Deletion 23128226

Relevant External Links for CAPN12 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN12 Gene

Disorders for CAPN12 Gene

No disorders were found for CAPN12 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CAPN12 Gene

Publications for CAPN12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. HIV gp120 induced gene expression signatures in vaginal epithelial cells. (PMID: 23867815) Fanibunda S.E. … Bandivdekar A.H. (Microbes Infect. 2013) 3
  3. Profiling proteins related to amyloid deposited brain of Tg2576 mice. (PMID: 15378736) Shin S.J. … Mook-Jung I. (Proteomics 2004) 23
  4. Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro. (PMID: 16388011) Ashizawa K. … Tsuzuki Y. (Reproduction 2006) 23
  5. Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene family. (PMID: 10964513) Dear T.N. … Boehm T. (Genomics 2000) 3

Products for CAPN12 Gene

Sources for CAPN12 Gene

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