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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPN11 Gene

protein-coding   GIFtS: 56
GCID: GC06P044126

calpain 11
 Explore 4 diseases affiliated with
CAPN11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CAPN11    

Aliases
for CAPN11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calpain 111 2     EC 3.4.22.-3
Calcium-Activated Neutral Proteinase 112 3     EC 3.4.228
CANP 112 3     EC 3.4.22.528
Calpain-111     EC 3.4.22.548
Calpain111     

External Ids:    HGNC: 14781   Entrez Gene: 111312   Ensembl: ENSG000001372257   OMIM: 6048225   UniProtKB: Q9UMQ63   

Export aliases for CAPN11 gene to outside databases

Previous GC identifers: GC06P044128 GC06P044173 GC06P044235 GC06P043847


Summaries
for CAPN11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CAPN11:
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this
superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears
to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in
spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. (provided by
RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: CAN11_HUMAN, Q9UMQ6
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in
cytoskeletal remodeling and signal transduction

summary for CAPN11:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).




Genomic Views
for CAPN11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPN11 gene promoter:
         COUP-TF1   Max1   COUP   LCR-F1   POU3F2   MZF-1   POU2F1   COUP-TF   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAPN11 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPN11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12

CAPN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN11 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P044126:  view genomic region     (about GC identifiers)

Start:
 44,126,548 bp from pter      End:
 44,152,139 bp from pter
Size:
 25,592 bases      Orientation:
 plus strand

Proteins
for CAPN11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CAN11_HUMAN, Q9UMQ6 (See protein sequence)
Recommended Name: Calpain-11  
Size: 739 amino acids; 84423 Da
Subunit: Heterodimer of a large (catalytic) and a small (regulatory) subunit
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity)
Sequence caution: Sequence=AAH33733.1; Type=Erroneous initiation; Sequence=BAG36761.1; Type=Erroneous initiation;
Sequence=CAB52137.1; Type=Erroneous initiation;
Secondary accessions: B2RA64 Q5T3G1 Q8N4R5

Explore the universe of human proteins at neXtProt for CAPN11: NX_Q9UMQ6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UMQ6

    • 4/11 DME Specific Peptides for CAPN11 (Q9UMQ6) (see all 11)
     YAGIFHF  PSTFEPH  KLVFVHS  YEALSGG 

    CAPN11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008989.2  
    ENSEMBL proteins: 
     ENSP00000432420   ENSP00000381758   ENSP00000431963   ENSP00000441078  

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    OriGene Protein Over-expression Lysate: CAPN11
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    Novus Biologicals CAPN11 Proteins
    Novus Biologicals CAPN11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CAPN11

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005622intracellular ----


    CAPN11 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CAPN11

    Protein Domains /
    Families
    for CAPN11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CAPN11 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR001300 Peptidase_C2_calpain_cat
     IPR018247 EF_Hand_1_Ca_BS
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry Q9UMQ6

    ProtoNet protein and cluster: Q9UMQ6

    1 Blocks protein family: IPB001300 Calpain cysteine protease (C2) family signature

    UniProtKB/Swiss-Prot: CAN11_HUMAN, Q9UMQ6
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 2 EF-hand domains


    Function
    for CAPN11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CAN11_HUMAN, Q9UMQ6
    Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in
    cytoskeletal remodeling and signal transduction
    Catalytic activity: Broad endopeptidase specificity

         Genatlas biochemistry entry for CAPN11:
    calpain 11,large polypeptide 11,calcium dependent,neutral cysteine proteinase,papain superfamily expressed in the
    testis

    Enzyme Numbers (IUBMB): EC 3.4.22.542 EC 3.4.222 EC 3.4.22.522 EC 3.4.22.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN11
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CAPN11:
    hsa-miR-922
    SwitchGear 3'UTR luciferase reporter plasmid: CAPN11 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for CAPN11

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008233peptidase activity TAS10409436


    CAPN11 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CAPN11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1DREAM Repression and Dynorphin Expression
    		nNOS Signaling in Skeletal Muscle0.37
    		Calpain Protease Regulates Cellular Mechanics0.22
    		Caspase Cascade0.24
    2Apoptosis Pathway
    		Apoptosis Pathway1.00
    3Integrin Pathway
    		FAK1 Signaling0.67
    4Rho Family GTPases
    		ERK Signaling0.61
    5Focal Adhesion
    		Integrin-mediated cell adhesion0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAPN11
        Caspase Cascade
    ERK Signaling
    Calpain Protease Regulates Cellular Mechanics
    FAK1 Signaling
    nNOS Signaling in Skeletal Muscle

    1 Tocris Bioscience Pathway for CAPN11
        Apoptosis Pathway

    1 BioSystems Pathway for CAPN11 
        Integrin-mediated cell adhesion


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAPN11

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CAPN11 (ENSP000003817584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC11ENSP000003499574STRING: ENSP00000349957
    PRKAR1AENSP000003514104STRING: ENSP00000351410
    UNGENSP000002425764STRING: ENSP00000242576
    XRCC6ENSP000003522574STRING: ENSP00000352257
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    CAPN11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CAPN11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for CAPN11:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CAPN11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CalpeptinCalpain and cathepsin L inhibitor[117591-20-5]
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPN11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CAPN11 / CAN11 

    Transcripts
    for CAPN11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CAPN11 gene: 
    NM_007058.3  

    Unigene Cluster for CAPN11:

    Calpain 11
    Hs.225953  [show with all ESTs]
    Unigene Representative Sequence: BC033733
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532171 ENST00000398776(uc003owt.1 uc011dvn.2) ENST00000526118
    ENST00000524554 ENST00000533604 ENST00000542245

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CAPN11:
    hsa-miR-922
    SwitchGear 3'UTR luciferase reporter plasmid: CAPN11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPN11 (see all 7)
    OriGene shRNA RFP: CAPN11
    OriGene siRNA: CAPN11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN11
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CAPN11 (NM_007058)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPN11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN11

    Additional cDNA sequence: 

    AJ242832.1 AK300107.1 AK314054.1 BC033733.1 

    4 DOTS entries:

    DT.92032960  DT.121312846  DT.121312873  DT.121312848 

    15 AceView cDNA sequences:

    BX280178 BQ925378 BI825216 BM554389 BG721593 BX345175 BI828421 AJ242832 
    BC033733 BP371443 NM_007058 CD243920 BI460638 BI850928 BI559807 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN11 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                          -                                                                       -                       -                                 
    SP2:              -                                                                                                                                             
    SP3:              -           -                                                                                                                                 
    SP4:              -           -                                                                                                                                 
    SP5:                          -                                                                                                                                 

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CAPN11

    Expression
    for CAPN11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPN11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTGCTGTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CAPN11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CAPN11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPN11

    SOURCE GeneReport for Unigene cluster: Hs.225953

    UniProtKB/Swiss-Prot: CAN11_HUMAN, Q9UMQ6
    Tissue specificity: Highest expression in testis

        SABiosciences Custom PCR Arrays for CAPN11
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    In Situ
    Assay Products:     
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    Orthologs
    for CAPN11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAPN11 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    fruit fly
    (Drosophila melanogaster)    		 Insecta CalpA3 actin cytoskeleton organization and
    biogenesis calpain less    		 47(a)
    (best of 3)    		   56D5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea clp-73   -- 43(a)
    (best of 3)    		   IV(1435632-1445971)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATDEK16
    		 calpain-type cysteine protease
    		 6(a)
    		 1 → many
    		 1(20653820-20665095)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 calpain, putative, expressed
    		 6(a)
    		 1 → many
    		 2(29335385-29352022)


    ENSEMBL Gene Tree for CAPN11 (if available)
    TreeFam Gene Tree for CAPN11 (if available) 

    Paralogs
    for CAPN11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAPN11 gene
    CAPN62  CAPN82  CAPN142  CAPN132  CAPN52  CAPN92  CAPN12  CAPN32  
    CAPN22  CAPN72  CAPN122  SOLH2  CAPN102  
    14 SIMAP similar genes for CAPN11 using alignment to 4 protein entries:     CAN11_HUMAN (see all proteins):
    CAPN2    CAPN1    CAPN8    CAPNS1    CAPNS2    CAPN9
    CAPN3    CAPN12    CAPN14    GCA    CAPN5    SRI
    CAPN13    CAPN6

    CAPN11 for paralogs           About GeneDecksing



    Genomic Variants
    for CAPN11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/616 NCBI SNPs in CAPN11 are shown (see all 616)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs763114541,2
    		F,--44124663(+) GCCTGT/ATTTCC 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1906522041,2
    		--44124766(+) TTAGCC/TGAGAC 1 -- us2k10--------
    rs1153424451,2
    		C,F,--44124948(+) ACACCC/TGTGCC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs93949871,2
    		C,F,A,H,--44124954(+) GTGCCT/CGCCTG 1 -- us2k17Minor allele frequency- C:0.42WA NA CSA EA 366
    rs1162953221,2
    		--44124964(+) GCACCC/TTACCC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs77537071,2
    		C,H,--44125104(+) TGGGGG/TCAGCA 1 -- us2k14Minor allele frequency- T:0.00NS EA 410
    rs1169833871,2
    		--44125117(+) AGATAC/GGGATA 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1379728711,2
    		--44125140(+) ATGGCC/TGGGCA 1 -- us2k10--------
    rs1135108681,2
    		--44125143(+) GCCGGG/ACACGG 1 -- us2k12Minor allele frequency- A:0.17CSA WA 120
    rs1435436711,2
    		--44125172(+) CTAGCA/GCTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAPN11 (44126548 - 44152139 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CAPN11
         3 CNVs: 93695 81383 81382

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    Disorders / Diseases
    for CAPN11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CAPN11 for disorders           About GeneDecksing

    OMIM gene information: 604822    OMIM disorders: --

    4 diseases for CAPN11:    About MalaCards
    muscular dystrophy    gastric cancer    alzheimer's disease    neuronitis


    Export disorders for CAPN11 gene to outside databases

    Publications
    for CAPN11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPN11 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CAPN11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CAPN11: a calpain with high mRNA levels in testis and located on chromosome 6. (PubMed id 10409436)1, 2, 3, 9 Dear T.N.... Boehm T. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Calpain 11 is unique to mouse spermatogenic cells. (PubMed id 16541461)1 Ben-Aharon I....Eddy E.M. (2006)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa. (PubMed id 10340998)1 Rojas F.J....Moretti-Rojas I. (1999)
    9. Calpain: new perspectives in molecular diversity and physiological-pathological involvement. (PubMed id 8070630)1 Saido T.C....Suzuki K. (1994)
    10. The calpains. (PubMed id 2479145)1 Melloni E. and Pontremoli S. (1989)

    External Searches for CAPN11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CAPN11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11131 HGNC: 1478 AceView: CAPN11 Ensembl:ENSG00000137225 euGenes: HUgn11131
    ECgene: CAPN11 H-InvDB: CAPN11

    Other Databases showing CAPN11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CAPN11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPN11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CAPN11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CAPN11 gene:
    Search GeneIP for patents involving CAPN11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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